The University of Queensland

Arbovirus Infections

Young, Paul R. (2023). Arbovirus Infections. Manson's tropical diseases. (pp. 172-201) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-7020-7959-7.00020-8

Arboviruses: a family on the move

Young, Paul R. (2018). Arboviruses: a family on the move. Dengue and Zika: Control and Antiviral Treatment Strategies. (pp. 1-10) edited by Rolf Hilgenfeld and Subhash G. Vasudevan. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-8727-1_1

Plugging the leak in Dengue shock

Watterson, Daniel, Modhiran, Naphak, Muller, David A., Stacey, Katryn J. and Young, Paul R. (2018). Plugging the leak in Dengue shock. Dengue and Zika: Control and Antiviral Treatment Strategies. (pp. 89-106) edited by Rolf Hilgenfeld and Subhash G. Vasudevan. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-8727-1_7

Viral entry and NS1 as potential antiviral drug targets

de Silva, Aravinda M., Rey, Félix A., Young, Paul R., Hilgenfeld, Rolf and Vasudevan, Subhash G. (2018). Viral entry and NS1 as potential antiviral drug targets. (pp. 107-113) Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-8727-1_8

Introduction to vaccines and vaccination

Depelsenaire, A. C. I., Kendall, M. A. F., Young, P. R. and Muller, D. A. (2017). Introduction to vaccines and vaccination. Micro and nanotechnology in vaccine development. (pp. 47-62) edited by Mariusz Skwarczynski and Istvan Toth. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-323-39981-4.00003-8

The nonstructural proteins of dengue virus

Chappell, Keith J. and Young, Paul R. (2014). The nonstructural proteins of dengue virus. Dengue and Dengue Hemorrhagic Fever: Second Edition. (pp. 377-405) edited by D. J. Gubler, Eng Eong Ooi, Subhash Vasudevan and Jeremy Farrar. Oxfordshire, United Kingdom: CABI International. doi: 10.1079/9781845939649.0377

Arbovirus Infections

Young, Paul R., Ng, Lisa F.P., Hall, Roy A., Smith, David W. and Johansen, Cheryl A. (2013). Arbovirus Infections. Manson's Tropical Diseases: Twenty-Third Edition. (pp. 129-161) edited by Jeremy Farrar. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-7020-5101-2.00015-7

The many faces of the flavivirus non-structural glycoprotein NS1

Muller, David and Young, Paul R. (2012). The many faces of the flavivirus non-structural glycoprotein NS1. Molecular virology and control of flaviviruses. (pp. 51-75) edited by Pei-Yong Shi. Norfolk, United Kingdom: Caister Academic Press.

Tumor-associated antigenic peptides as vaccine candidates

Hans, Dhiraj, Young, Paul R. and Fairlie, David P. (2009). Tumor-associated antigenic peptides as vaccine candidates. Tumor-associated antigens. (pp. 303-316) edited by Olivier Gires and Barbara Seliger. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/9783527625970.ch17

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1), 1-6. doi: 10.1099/jgv.0.001947

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine

Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L.D., Choo, Jovin J.Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka and Muller, David A. (2023). Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular Therapy Nucleic Acids, 34 102056, 102056. doi: 10.1016/j.omtn.2023.102056

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

Pegg, Cassandra L., Modhiran, Naphak, Parry, Rhys H., Liang, Benjamin, Amarilla, Alberto A., Khromykh, Alexander A., Burr, Lucy, Young, Paul R., Chappell, Keith, Schulz, Benjamin L. and Watterson, Daniel (2023). The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology cwad097, 1-13. doi: 10.1093/glycob/cwad097

Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial

Baker, Ben, Bermingham, Imogen M., Leelasena, Indika, Hickling, Julian, Young, Paul R., Muller, David A. and Forster, Angus H. (2023). Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial. Vaccines, 11 (11) 1725, 1-17. doi: 10.3390/vaccines11111725

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842, 104842. doi: 10.1016/j.ebiom.2023.104842

Microarray patches: scratching the surface of vaccine delivery

Choo, Jovin J. Y., McMillan, Christopher L. D., Young, Paul R. and Muller, David A. (2023). Microarray patches: scratching the surface of vaccine delivery. Expert Review of Vaccines, 22 (1), 937-955. doi: 10.1080/14760584.2023.2270598

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3), e0016523. doi: 10.1128/msphere.00165-23

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3), e0081523. doi: 10.1128/mbio.00815-23

Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS)

Rappuoli, Rino, Young, Paul, Ron, Eliora, Pecetta, Simone and Pizza, Mariagrazia (2023). Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS). One Health Outlook, 5 (1) 5, 5. doi: 10.1186/s42522-023-00077-2

Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119)

Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2023). Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119). Proceedings of the National Academy of Sciences of the United States of America, 120 (1) e2220541120. doi: 10.1073/pnas.2220541120

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97 (5). doi: 10.1128/jvi.00451-23

Diversity and transmission of koala retrovirus: a case study in three captive koala populations

Joyce, Briony A., Blyton, Michaela D. J., Johnston, Stephen D., Meikle, William D., Vinette Herrin, Kimberly, Madden, Claire, Young, Paul R. and Chappell, Keith J. (2022). Diversity and transmission of koala retrovirus: a case study in three captive koala populations. Scientific Reports, 12 (1) 15787, 1-8. doi: 10.1038/s41598-022-18939-6

Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine

O’Donnell, Jake S., Isaacs, Ariel, Jakob, Virginie, Lebas, Celia, Barnes, James B., Reading, Patrick C., Young, Paul R., Watterson, Daniel, Dubois, Patrice M., Collin, Nicolas and Chappell, Keith J. (2022). Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine. Frontiers in Immunology, 13 976968, 976968. doi: 10.3389/fimmu.2022.976968

A platform technology for generating subunit vaccines against diverse viral pathogens

Young, Andrew, Isaacs, Ariel, Scott, Connor A. P., Modhiran, Naphak, McMillan, Christopher L. D., Cheung, Stacey T. M., Barr, Jennifer, Marsh, Glenn, Thakur, Nazia, Bailey, Dalan, Li, Kenneth S. M., Luk, Hayes K. H., Kok, Kin-Hang, Lau, Susanna K. P., Woo, Patrick C. Y., Furuyama, Wakako, Marzi, Andrea, Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2022). A platform technology for generating subunit vaccines against diverse viral pathogens. Frontiers in Immunology, 13 963023, 1-16. doi: 10.3389/fimmu.2022.963023

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

McMillan, Christopher L.D., Amarilla, Alberto A., Modhiran, Naphak, Choo, Jovin J.Y., Azuar, Armira, Honeyman, Kate E., Khromykh, Alexander A., Young, Paul R., Watterson, Daniel and Muller, David A. (2022). Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. Vaccine, 40 (34), 4929-4932. doi: 10.1016/j.vaccine.2022.07.013

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions

Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2022). Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proceedings of the National Academy of Sciences, 119 (33) e2122680119, 1-11. doi: 10.1073/pnas.2122680119

Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants

Isaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262

Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas

Blyton, Michaela D. J., Pyne, Michael, Young, Paul and Chappell, Keith (2022). Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas. PLoS Pathogens, 18 (5) e1010513, 1-20. doi: 10.1371/journal.ppat.1010513

Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856

Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern

McMillan, Christopher L. D., Azuar, Armira, Choo, Jovin J. Y., Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Honeyman, Kate E., Cheung, Stacey T. M., Liang, Benjamin, Wurm, Maria J., Pino, Paco, Kint, Joeri, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Hobson-Peters, Jody, Watterson, Daniel, Young, Paul R. and Muller, David A. (2022). Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern. Vaccines, 10 (4) 578, 578. doi: 10.3390/vaccines10040578

Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction

Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung ... Turnbull, Jeremy E. (2022). Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction. ACS Central Science, 8 (5) acscentsci.1c01293, 527-545. doi: 10.1021/acscentsci.1c01293

Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses

McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2022). Author Correction: Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 7 (1) 3, 3. doi: 10.1038/s41541-021-00428-y

Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay

Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493

Retroviral integrations contribute to elevated host cancer rates during germline invasion

McEwen, Gayle K., Alquezar-Planas, David E., Dayaram, Anisha, Gillett, Amber, Tarlinton, Rachael, Mongan, Nigel, Chappell, Keith J., Henning, Joerg, Tan, Milton, Timms, Peter, Young, Paul R., Roca, Alfred L. and Greenwood, Alex D. (2021). Retroviral integrations contribute to elevated host cancer rates during germline invasion. Nature Communications, 12 (1) 1316, 1-13. doi: 10.1038/s41467-021-21612-7

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Selva, Kevin J., van de Sandt, Carolien E., Lemke, Melissa M., Lee, Christina Y., Shoffner, Suzanne K., Chua, Brendon Y., Davis, Samantha K., Nguyen, Thi H. O., Rowntree, Louise C., Hensen, Luca, Koutsakos, Marios, Wong, Chinn Yi, Mordant, Francesca, Jackson, David C., Flanagan, Katie L., Crowe, Jane, Tosif, Shidan, Neeland, Melanie R., Sutton, Philip, Licciardi, Paul V., Crawford, Nigel W., Cheng, Allen C., Doolan, Denise L., Amanat, Fatima, Krammer, Florian, Chappell, Keith, Modhiran, Naphak, Watterson, Daniel, Young, Paul ... Chung, Amy W. (2021). Systems serology detects functionally distinct coronavirus antibody features in children and elderly. Nature Communications, 12 (1) 2037, 2037. doi: 10.1038/s41467-021-22236-7

Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patch

Choo, Jovin J. Y., McMillan, Christopher L. D., Fernando, Germain J. P., Hall, Roy A., Young, Paul R., Hobson-Peters, Jody and Muller, David A. (2021). Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patch. Vaccines, 9 (11) 1301. doi: 10.3390/vaccines9111301

Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses

McMillan, Christopher L. D., Cheung, Stacey T. M., Modhiran, Naphak, Barnes, James, Amarilla, Alberto A., Bielefeldt-Ohmann, Helle, Lee, Leo Yi Yang, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Jakob, Virginie, Lebas, Celia, Reading, Patrick, Short, Kirsty R., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2021). Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses. npj Vaccines, 6 (1) 135, 135. doi: 10.1038/s41541-021-00395-4

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Cheung, Stacey T. M., Liang, Benjamin, Bielefeldt-Ohmann, Helle, Azuar, Armira, Acharya, Dhruba, Kelly, Gabrielle, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., McMillan, Nigel A. J. and Muller, David A. (2021). Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine. Science Advances, 7 (44) eabj8065, eabj8065. doi: 10.1126/sciadv.abj8065

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0

Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates

Isaacs, Ariel, Cheung, Stacey T. M., Thakur, Nazia, Jaberolansar, Noushin, Young, Andrew, Modhiran, Naphak, Bailey, Dalan, Graham, Simon P., Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2021). Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates. Viruses, 13 (10) 1942. doi: 10.3390/v13101942

Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5‐years of life

Takashima, Mari D., Grimwood, Keith, Sly, Peter D., Lambert, Stephen B., Chappell, Keith J., Watterson, Daniel, Young, Paul, Kusel, Merci, Holt, Barbara, Holt, Patrick and Ware, Robert S. (2021). Cord‐blood respiratory syncytial virus antibodies and respiratory health in first 5‐years of life. Pediatric Pulmonology, 56 (12), 3942-3951. doi: 10.1002/ppul.25688

Koala retrovirus genetic diversity and transmission dynamics within captive koala populations

Joyce, Briony A., Blyton, Michaela D. J., Johnston, Stephen D., Young, Paul R. and Chappell, Keith J. (2021). Koala retrovirus genetic diversity and transmission dynamics within captive koala populations. National Academy of Sciences. Proceedings, 118 (38) e2024021118, e2024021118. doi: 10.1073/pnas.2024021118

Implications of dengue virus maturation on vaccine induced humoral immunity in mice

Scott, Connor A. P., Amarilla, Alberto A., Bibby, Summa, Newton, Natalee D., Hall, Roy A., Hobson-Peters, Jody, Muller, David A., Chappell, Keith J., Young, Paul R., Modhiran, Naphak and Watterson, Daniel (2021). Implications of dengue virus maturation on vaccine induced humoral immunity in mice. Viruses, 13 (9) 1843, 1843. doi: 10.3390/v13091843

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

Amarilla, Alberto A., Sng, Julian D. J., Parry, Rhys, Deerain, Joshua M., Potter, James R., Setoh, Yin Xiang, Rawle, Daniel J., Le, Thuy T., Modhiran, Naphak, Wang, Xiaohui, Peng, Nias Y. G., Torres, Francisco J., Pyke, Alyssa, Harrison, Jessica J., Freney, Morgan E., Liang, Benjamin, McMillan, Christopher L. D., Cheung, Stacey T. M., Guevara, Darwin J Da Costa, Hardy, Joshua M., Bettington, Mark, Muller, David A., Coulibaly, Fasséli, Moore, Frederick, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Hobson-Peters, Jody, Suhrbier, Andreas ... Khromykh, Alexander A. (2021). A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses. Nature Communications, 12 (1) 3431, 3431. doi: 10.1038/s41467-021-23779-5

A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses

Hardy, Joshua M., Newton, Natalee D., Modhiran, Naphak, Scott, Connor A. P., Venugopal, Hariprasad, Vet, Laura J., Young, Paul R., Hall, Roy A., Hobson-Peters, Jody, Coulibaly, Fasséli and Watterson, Daniel (2021). A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses. Nature Communications, 12 (1) 3266, 3266. doi: 10.1038/s41467-021-22773-1

A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice

Choo, Jovin J. Y., Vet, Laura J., McMillan, Christopher L. D., Harrison, Jessica J., Scott, Connor A. P., Depelsenaire, Alexandra C. I., Fernando, Germain J. P., Watterson, Daniel, Hall, Roy A., Young, Paul R., Hobson-Peters, Jody and Muller, David A. (2021). A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice. npj Vaccines, 6 (1) 66, 66. doi: 10.1038/s41541-021-00328-1

Assessing the potential of unmanned aerial vehicle spraying of aqueous ozone as an outdoor disinfectant for SARS-CoV-2

Albert, Simon, Amarilla, Alberto A., Trollope, Ben, Sng, Julian D.J., Setoh, Yin Xiang, Deering, Nathaniel, Modhiran, Naphak, Weng, Sung-Hsia, Melo, Maria C., Hutley, Nicholas, Nandy, Avik, Furlong, Michael J., Young, Paul R., Watterson, Daniel, Grinham, Alistair R. and Khromykh, Alexander A. (2021). Assessing the potential of unmanned aerial vehicle spraying of aqueous ozone as an outdoor disinfectant for SARS-CoV-2. Environmental Research, 196 110944, 110944. doi: 10.1016/j.envres.2021.110944

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel, Wijesundara, Danushka K., Modhiran, Naphak, Mordant, Francesca L., Li, Zheyi, Avumegah, Michael S., McMillan, Christopher L. D., Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey T. M., Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L., Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam ... Chappell, Keith J. (2021). Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clinical & Translational Immunology, 10 (4) e1269, e1269. doi: 10.1002/cti2.1269

Discovery of sisunatovir (RV521), an inhibitor of respiratory syncytial virus fusion

Cockerill, G. Stuart, Angell, Richard M., Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A., Good, James A. D., Harland, Rachel, Johnson, Sara M., Ludes-Meyers, John H., Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S., Paradowski, Michael, Peeples, Mark E., Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E., Watterson, Daniel, Williams, Gareth, Young, Paul and Powell, Kenneth (2021). Discovery of sisunatovir (RV521), an inhibitor of respiratory syncytial virus fusion. Journal of Medicinal Chemistry, 64 (7) acs.jmedchem.0c01882, 3658-3676. doi: 10.1021/acs.jmedchem.0c01882

An optimized high-throughput immuno-plaque assay for SARS-CoV-2

Amarilla, Alberto A., Modhiran, Naphak, Setoh, Yin Xiang, Peng, Nias Y. G., Sng, Julian D. J., Liang, Benjamin, McMillan, Christopher L. D., Freney, Morgan E, Cheung, Stacey T. M., Chappell, Keith J., Khromykh, Alexander A., Young, Paul R. and Watterson, Daniel (2021). An optimized high-throughput immuno-plaque assay for SARS-CoV-2. Frontiers in Microbiology, 12 625136, 625136. doi: 10.3389/fmicb.2021.625136

Adjuvant selection for influenza and RSV prefusion subunit vaccines

Isaacs, Ariel, Li, Zheyi, Cheung, Stacey T. M., Wijesundara, Danushka K., McMillan, Christopher L. D., Modhiran, Naphak, Young, Paul R., Ranasinghe, Charani, Watterson, Daniel and Chappell, Keith J. (2021). Adjuvant selection for influenza and RSV prefusion subunit vaccines. Vaccines, 9 (2) 71, 1-14. doi: 10.3390/vaccines9020071

A broadly protective antibody that targets the flavivirus NS1 protein

Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A., Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T. M., Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A. P., Freney, Morgan E., Newton, Natalee D., Khromykh, Alexander A., Chappell, Keith J., Muller, David A., Stacey, Katryn J., Landsberg, Michael J., Shi, Yi, Gao, George F., Young, Paul R. and Watterson, Daniel (2021). A broadly protective antibody that targets the flavivirus NS1 protein. Science, 371 (6525), 190-194. doi: 10.1126/science.abb9425

First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2

Chappell, Keith Joseph, Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia, Cheung, Stacey, Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Bennet, Jillian, Hensen, Luca, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., AW, Chung, Tran, Mai H., Tapley, Peter, Reading, Patrick, Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P. Mark, Kedzierska, Katherine, Purcell, Damian, Ranasinghe, Charani, Subbarao, Kanta ... Munro, Trent P. (2021). First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2. SSRN Electronic Journal. doi: 10.2139/ssrn.3769210

The next generation of influenza vaccines: towards a universal solution

McMillan, Christopher L. D., Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2021). The next generation of influenza vaccines: towards a universal solution. Vaccines, 9 (1) 26, 1-20. doi: 10.3390/vaccines9010026

Rapid response subunit vaccine design in the absence of structural information

Wijesundara, Danushka K., Avumegah, Michael S., Lackenby, Julia, Modhiran, Naphak, Isaacs, Ariel, Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2020). Rapid response subunit vaccine design in the absence of structural information. Frontiers in Immunology, 11 592370, 592370. doi: 10.3389/fimmu.2020.592370

Inactivation of Japanese encephalitis virus in plasma by methylene blue combined with visible light and in platelet concentrates by ultraviolet C light

Rustanti, Lina, Hobson-Peters, Jody, Colmant, Agathe M. G., Hall, Roy A., Young, Paul R., Reichenberg, Stefan, Tolksdorf, Frank, Sumian, Chryslain, Gravemann, Ute, Seltsam, Axel, Marks, Denese C. and Faddy, Helen Z. M. (2020). Inactivation of Japanese encephalitis virus in plasma by methylene blue combined with visible light and in platelet concentrates by ultraviolet C light. Transfusion, 60 (11), 2655-2660. doi: 10.1111/trf.16021

Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

Thakur, Nazia, Conceicao, Carina, Isaacs, Ariel, Human, Stacey, Modhiran, Naphak, McLean, Rebecca K., Pedrera, Miriam, Tan, Tiong Kit, Rijal, Pramila, Townsend, Alain, Taylor, Geraldine, Young, Paul R., Watterson, Daniel, Chappell, Keith J., Graham, Simon P. and Bailey, Dalan (2020). Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion. Journal of General Virology, 102 (1) 001506. doi: 10.1099/jgv.0.001506

Disease X ver1.0: COVID-19

Young, Paul R. (2020). Disease X ver1.0: COVID-19. Microbiology Australia, 41 (2), 109-112. doi: 10.1071/MA20028

Arthritogenic alphavirus vaccines: serogrouping versus cross-protection in mouse models

Nguyen, Wilson, Nakayama, Eri, Yan, Kexin, Tang, Bing, Le, Thuy T., Liu, Liang, Cooper, Tamara H., Hayball, John D., Faddy, Helen M., Warrilow, David, Allcock, Richard J. N., Hobson-Peters, Jody, Hall, Roy A., Rawle, Daniel J., Lutzky, Viviana P., Young, Paul, Oliveira, Nidia M., Hartel, Gunter, Howley, Paul M., Prow, Natalie A. and Suhrbier, Andreas (2020). Arthritogenic alphavirus vaccines: serogrouping versus cross-protection in mouse models. Vaccines, 8 (2) 209, 209. doi: 10.3390/vaccines8020209

Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood

Brealey, Jaelle C., Young, Paul R., Sloots, Theo P., Ware, Robert S., Lambert, Stephen B., Sly, Peter D., Grimwood, Keith and Chappell, Keith J. (2020). Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood. Pediatric Pulmonology, 55 (5) ppul.24715, 1237-1245. doi: 10.1002/ppul.24715

Bovine herpesvirus-4-vectored delivery of nipah virus glycoproteins enhances T cell immunogenicity in pigs

Pedrera, Miriam, Macchi, Francesca, McLean, Rebecca K., Franceschi, Valentina, Thakur, Nazia, Russo, Luca, Medfai, Lobna, Todd, Shawn, Tchilian, Elma Z., Audonnet, Jean-Christophe, Chappell, Keith, Isaacs, Ariel, Watterson, Daniel, Young, Paul R., Marsh, Glenn A., Bailey, Dalan, Graham, Simon P. and Donofrio, Gaetano (2020). Bovine herpesvirus-4-vectored delivery of nipah virus glycoproteins enhances T cell immunogenicity in pigs. Vaccines, 8 (1) 115, 115. doi: 10.3390/vaccines8010115

Flow-cytometry detection of fluorescent magnetic nanoparticle clusters increases sensitivity of dengue immunoassay

Sanjaya, K.C., Ranzoni, Andrea, Hung, Jacky, Blaskovich, Mark A.T., Watterson, Daniel, Young, Paul R. and Cooper, Matthew A. (2020). Flow-cytometry detection of fluorescent magnetic nanoparticle clusters increases sensitivity of dengue immunoassay. Analytica Chimica Acta, 1107, 85-91. doi: 10.1016/j.aca.2020.02.007

Granzyme A in chikungunya and other arboviral infections

Schanoski, Alessandra S., Le, Thuy T., Kaiserman, Dion, Rowe, Caitlin, Prow, Natalie A., Barboza, Diego D., Santos, Cliomar A., Zanotto, Paolo M A, Magalhães, Kelly G., Aurelio, Luigi, Muller, David, Young, Paul, Zhao, Peishen, Bird, Phillip I. and Suhrbier, Andreas (2020). Granzyme A in chikungunya and other arboviral infections. Frontiers in Immunology, 10 3083, 1-14. doi: 10.3389/fimmu.2019.03083

A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus

Hobson-Peters, Jody, Harrison, Jessica J., Watterson, Daniel, Hazlewood, Jessamine E., Vet, Laura J., Newton, Natalee D., Warrilow, David, Colmant, Agathe M. G., Taylor, Carmel, Huang, Bixing, Piyasena, Thisun B. H., Chow, Weng Kong, Setoh, Yin Xiang, Tang, Bing, Nakayama, Eri, Yan, Kexin, Amarilla, Alberto A., Wheatley, Sarah, Moore, Peter R., Finger, Mitchell, Kurucz, Nina, Modhiran, Naphak, Young, Paul R., Khromykh, Alexander A., Bielefeldt-Ohmann, Helle, Suhrbier, Andreas and Hall, Roy A. (2019). A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus. Science Translational Medicine, 11 (522) eaax7888, 1-15. doi: 10.1126/scitranslmed.aax7888

Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti

Novelo, Mario, Hall, Matthew D., Pak, Damie, Young, Paul R., Holmes, Edward C. and McGraw, Elizabeth A. (2019). Intra-host growth kinetics of dengue virus in the mosquito Aedes aegypti. PLoS Pathogens, 15 (12) e1008218, e1008218. doi: 10.1371/journal.ppat.1008218

Efficient delivery of dengue virus subunit vaccines to the skin by microprojection arrays

Muller, David A., Depelsenaire, Alexandra C. I., Shannon, Ashleigh E., Watterson, Daniel, Corrie, Simon R., Owens, Nick S., Agyei-Yeboah, Christiana, Cheung, Stacey T. M., Zhang, Jin, Fernando, Germain J. P., Kendall, Mark A. F. and Young, Paul R. (2019). Efficient delivery of dengue virus subunit vaccines to the skin by microprojection arrays. Vaccines, 7 (4) 189, 189. doi: 10.3390/vaccines7040189

Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections

Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2019). Analysis of phylogenetic diversity and in vitro adherence characteristics of respiratory syncytial virus and Streptococcus pneumoniae clinical isolates obtained during pediatric respiratory co-infections. Microbiology, 166 (1) 000870, 63-72. doi: 10.1099/mic.0.000870

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon

Tan, Yuen P., Xue, Yongbo, Savchenko, Andrei I., Houston, Sevan D., Modhiran, Naphak, McMillan, Christopher L. D., Boyle, Glen M., Bernhardt, Paul V., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon. Journal of Natural Products, 82 (10) acs.jnatprod.9b00522, 2828-2834. doi: 10.1021/acs.jnatprod.9b00522

Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545

Modhiran, Naphak, Gandhi, Neha S., Wimmer, Norbert, Cheung, Stacey, Stacey, Katryn, Young, Paul R., Ferro, Vito and Watterson, Daniel (2019). Dual targeting of dengue virus virions and NS1 protein with the heparan sulfate mimic PG545. Antiviral Research, 168, 121-127. doi: 10.1016/j.antiviral.2019.05.004

Determinants of Zika virus host tropism uncovered by deep mutational scanning

Setoh, Yin Xiang, Amarilla, Alberto A., Peng, Nias Y. G., Griffiths, Rebecca E., Carrera, Julio, Freney, Morgan E., Nakayama, Eri, Ogawa, Shinya, Watterson, Daniel, Modhiran, Naphak, Nanyonga, Faith Elizabeth, Torres, Francisco J., Slonchak, Andrii, Periasamy, Parthiban, Prow, Natalie A., Tang, Bing, Harrison, Jessica, Hobson-Peters, Jody, Cuddihy, Thom, Cooper-White, Justin, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Wolvetang, Ernst, Bloom, Jesse D., Suhrbier, Andreas and Khromykh, Alexander A. (2019). Determinants of Zika virus host tropism uncovered by deep mutational scanning. Nature Microbiology, 4 (5), 876-887. doi: 10.1038/s41564-019-0399-4

Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon

Tan, Yuen P., Houston, Sevan D., Modhiran, Naphak, Savchenko, Andrei I., Boyle, Glen M., Young, Paul R., Watterson, Daniel and Williams, Craig M. (2019). Stachyonic acid: a dengue virus inhibitor from Basilicum polystachyon. Chemistry – A European Journal, 25 (22) chem.201900591, 5664-5667. doi: 10.1002/chem.201900591

Inactivation of yellow fever virus in plasma after treatment with methylene blue and visible light and in platelet concentrates following treatment with ultraviolet C light

Faddy, Helen M., Fryk, Jesse J., Hall, Roy A., Young, Paul R., Reichenberg, Stefan, Tolksdorf, Frank, Sumian, Chryslain, Gravemann, Ute, Seltsam, Axel and Marks, Denese C. (2019). Inactivation of yellow fever virus in plasma after treatment with methylene blue and visible light and in platelet concentrates following treatment with ultraviolet C light. Transfusion, 59 (7) trf.15332, 2223-2227. doi: 10.1111/trf.15332

Sustained Wolbachia-mediated blocking of dengue virus isolates following serial passage in Aedes aegypti cell culture

Koh, Cassandra, Audsley, Michelle D., Di Giallonardo, Francesca, Kerton, Emily J., Young, Paul R., Holmes, Edward C. and McGraw, Elizabeth A. (2019). Sustained Wolbachia-mediated blocking of dengue virus isolates following serial passage in Aedes aegypti cell culture. Virus Evolution, 5 (1) vez012, vez012. doi: 10.1093/ve/vez012

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion

Löber, Ulrike, Hobbs, Matthew, Dayaram, Anisha, Tsangaras, Kyriakos, Jones, Kiersten, Alquezar-Planas, David E., Ishida, Yasuko, Meers, Joanne, Mayer, Jens, Quedenau, Claudia, Chen, Wei, Johnson, Rebecca N., Timms, Peter, Young, Paul R., Roca, Alfred L. and Greenwood, Alex D. (2018). Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion. Proceedings of the National Academy of Sciences of the United States of America, 115 (34), 8609-8614. doi: 10.1073/pnas.1807598115

Complete genome of Aedes aegypti anphevirus in the Aag2 mosquito cell line

Di Giallonardo, Francesca, Audsley, Michelle D., Shi, Mang, Young, Paul R., McGraw, Elizabeth A. and Holmes, Edward C. (2018). Complete genome of Aedes aegypti anphevirus in the Aag2 mosquito cell line. The Journal of General Virology, 99 (6) 001079, 832-836. doi: 10.1099/jgv.0.001079

Antibody-binding, antifouling surface coatings based on recombinant expression of zwitterionic EK peptides

Walker, Julia A., Robinson, Kye J., Munro, Christopher, Gengenbach, Thomas, Muller, David A., Young, Paul R., Lua, Linda H. L. and Corrie, Simon R. (2018). Antibody-binding, antifouling surface coatings based on recombinant expression of zwitterionic EK peptides. Langmuir, 35 (5) acs.langmuir.8b00810, 1266-1272. doi: 10.1021/acs.langmuir.8b00810

Communication ambassadors - an Australian social media initiative to develop communication skills in early career scientists

Wang, Jack T. H., Power, Cheryl J., Kahler, Charlene M., Lyras, Dena, Young, Paul R., Iredell, Jonathan and Robins-Browne, Roy (2018). Communication ambassadors - an Australian social media initiative to develop communication skills in early career scientists. Journal of Microbiology and Biology Education, 19 (1) 1428. doi: 10.1128/jmbe.v19i1.1428

Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection

Chan, Kok Fei, Carolan, Louise A., Druce, Julian, Chappell, Keith, Watterson, Daniel, Young, Paul, Korenkov, Daniil, Subbarao, Kanta, Barr, Ian G., Laurie, Karen L. and Reading, Patrick C. (2018). Pathogenesis, humoral immune responses and transmission between co-housed animals in a ferret model of human RSV infection. Journal of Virology, 92 (4) e01322-17, 1-17. doi: 10.1128/JVI.01322-17

Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children

Brealey, Jaelle C., Chappell, Keith J., Galbraith, Sally, Fantino, Emmanuelle, Gaydon, Jane, Tozer, Sarah, Young, Paul R., Holt, Patrick G. and Sly, Peter D. (2018). Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children. Respirology, 23 (2), 220-227. doi: 10.1111/resp.13179

The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion

Bermingham, Imogen M., Chappell, Keith J., Watterson, Daniel and Young, Paul R. (2018). The heptad repeat C domain of the respiratory syncytial virus fusion protein plays a key role in membrane fusion. Journal of Virology, 92 (4) e01323-17, 1-14. doi: 10.1128/JVI.01323-17

Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope

Li, Jie, Watterson, Daniel, Chang, Chiung-Wen, Che, Xiao-Yan, Li, Xiao-Quan, Ericsson, Daniel J., Qiu, Li-Wen, Cai, Jian-Piao, Chen, Jing, Fry, Scott R., Cheung, Stacey T. M., Cooper, Matthew A., Young, Paul R. and Kobe, Bostjan (2018). Structural and functional characterization of a cross-reactive dengue virus neutralizing antibody that recognizes a cryptic epitope. Structure, 26 (1), 51-59. doi: 10.1016/j.str.2017.11.017

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein

Jaberolansar, Noushin, Chappell, Keith J., Watterson, Daniel, Bermingham, Imogen M., Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2017). Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein. Scientific Reports, 7 (1) 11130, 11130. doi: 10.1038/s41598-017-10415-w

Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light

Fryk, Jesse J., Marks, Denese C., Hobson-Peters, Jody, Watterson, Daniel, Hall, Roy A., Young, Paul R., Reichenberg, Stefan, Tolksdorf, Frank, Sumian, Chryslain, Gravemann, Ute, Seltsam, Axel and Faddy, Helen M. (2017). Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light. Transfusion, 57 (11), 2677-2682. doi: 10.1111/trf.14256

High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses

Muller, David A., Fernando, Germain J. P., Owens, Nick S., Agyei-Yeboah, Christiana, Wei, Jonathan C. J., Depelsenaire, Alexandra C. I., Forster, Angus, Fahey, Paul, Weldon, William C., Oberste, M. Steven, Young, Paul R. and Kendall, Mark A. F. (2017). High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses. Scientific Reports, 7 (1) 12644, 12644. doi: 10.1038/s41598-017-13011-0

Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay

Lebani, Kebaneilwe, Jones, Martina L., Watterson, Daniel, Ranzoni, Andrea, Traves, Renee J., Young, Paul R. and Mahler, Stephen M. (2017). Isolation of serotype-specific antibodies against dengue virus non-structural protein 1 using phage display and application in a multiplexed serotyping assay. PLoS One, 12 (7) e0180669, e0180669. doi: 10.1371/journal.pone.0180669

Clinical and laboratory diagnosis of dengue virus infection

Muller, David A., Depelsenaire, Alexandra C. I. and Young, Paul R. (2017). Clinical and laboratory diagnosis of dengue virus infection. Journal of Infectious Diseases, 215 (2), S89-S95. doi: 10.1093/infdis/jiw649

Computational identification of antibody epitopes on the dengue virus NS1 protein

Jones, Martina L., Legge, Fiona S., Lebani, Kebaneilwe, Mahler, Stephen M., Young, Paul R., Watterson, Daniel, Treutlein, Herbert R. and Zeng, Jun (2017). Computational identification of antibody epitopes on the dengue virus NS1 protein. Molecules, 22 (4) 607, 607. doi: 10.3390/molecules22040607

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6

Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017). Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 (5), 491-495. doi: 10.1038/icb.2017.5

Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG

Pyankov, Oleg V., Setoh, Yin Xiang, Bodnev, Sergey A., Edmonds, Judith H., Pyankova, Olga G., Pyankov, Stepan A., Pali, Gabor, Belford, Shane, Lu, Louis, La, Mylinh, Lovrecz, George, Volchkova, Valentina A., Chappell, Keith J., Watterson, Daniel, Marsh, Glenn, Young, Paul R., Agafonov, Alexander A., Farmer, Jillann F., Volchkov, Victor E., Suhrbier, Andreas and Khromykh, Alexander A. (2017). Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG. Scientific Reports, 7 (1) 41537, 41537. doi: 10.1038/srep41537

Investigating the effect of substrate materials on wearable immunoassay performance

Lee, Khai T., Coffey, Jacob W., Robinson, Kye J., Muller, David A., Grondahl, Lisbeth, Kendall, Mark A. F., Young, Paul R. and Corrie, Simon R. (2017). Investigating the effect of substrate materials on wearable immunoassay performance. Langmuir, 33 (3), 773-782. doi: 10.1021/acs.langmuir.6b03933

Product release is rate-limiting for catalytic processing by the Dengue virus protease

Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539

Phylogenetic diversity of koala retrovirus within a wild koala population

Chappell, K. J., Brealey, J. C., Amarilla, A. A., Watterson, D., Hulse, L., Palmieri, C., Johnston, S. D., Holmes, E. C., Meers, J. and Young, P. (2016). Phylogenetic diversity of koala retrovirus within a wild koala population. Journal of Virology, 91 (3) e01820-16, 363-374. doi: 10.1128/JVI.01820-16

Viral pathogen vaccines

Young, Paul, Chappell, Keith and Watterson, Dan (2016). Viral pathogen vaccines. Australasian Biotechnology, 26 (3), 35-35.

Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light

Fryk, Jesse J., Marks, Denese C., Hobson-Peters, Jody, Prow, Natalie A., Watterson, Daniel, Hall, Roy A., Young, Paul R., Reichenberg, Stefan, Sumian, Chryslain and Faddy, Helen M. (2016). Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light. Transfusion, 56 (9), 2278-2285. doi: 10.1111/trf.13729

Riboflavin and ultraviolet light: impact on dengue virus infectivity

Faddy, H. M., Fryk, J. J., Watterson, D., Young, P. R., Modhiran, N., Muller, D. A., Keil, S. D., Goodrich, R. P. and Marks, D. C. (2016). Riboflavin and ultraviolet light: impact on dengue virus infectivity. Vox Sanguinis, 111 (3), 235-241. doi: 10.1111/vox.12414

Inactivation of dengue, chikungunya, and Ross River viruses in platelet concentrates after treatment with ultraviolet C light

Faddy, Helen M., Fryk, Jesse J., Prow, Natalie A., Watterson, Daniel, Young, Paul R., Hall, Roy A., Tolksdorf, Frank, Sumian, Chryslain, Gravemann, Ute, Seltsam, Axel and Marks, Denese C. (2016). Inactivation of dengue, chikungunya, and Ross River viruses in platelet concentrates after treatment with ultraviolet C light. Transfusion, 56 (6pt2), 1548-1555. doi: 10.1111/trf.13519

The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design

Watterson, Daniel, Modhiran, Naphak and Young, Paul R. (2016). The many faces of the flavivirus NS1 protein offer a multitude of options for inhibitor design. Antiviral Research, 130, 7-18. doi: 10.1016/j.antiviral.2016.02.014

A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance

Watterson, Daniel, Robinson, Jodie, Chappell, Keith J., Butler, Mark S., Edwards, David J., Fry, Scott R., Bermingham, Imogen M., Cooper, Matthew A. and Young, Paul R. (2016). A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance. Scientific Reports, 6 (22791) 22791, 1-9. doi: 10.1038/srep22791

Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses

Muller, David A., Pearson, Frances E., Fernando, Germain J. P., Agyei-Yeboah, Christiana, Owens, Nick S., Corrie, Simon R., Crichton, Michael L., Wei, Jonathan C. J., Weldon, William C., Oberste, M. Steven, Young, Paul R. and Kendall, Mark A. F. (2016). Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responses. Scientific Reports, 6 (22094) 22094, 1-7. doi: 10.1038/srep22094

Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination"

Stacey, Katryn J., Watterson, Daniel, Modhiran, Naphak and Young, Paul R. (2015). Response to comment on "Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity" and "Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination". Science Translational Medicine, 7 (318) 318lr4, 318lr4-318lr4. doi: 10.1126/scitranslmed.aad8657

Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue

Robinson, Kye J., Coffey, Jacob W., Muller, David A., Young, Paul R., Kendall, Mark A., Thurecht, Kristofer J., Grøndahl, Lisbeth and Corrie, Simon R. (2015). Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue. Biointerphases, 10 (4) 04A305, 04A305.1-04A305.11. doi: 10.1116/1.4932055

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022

Quantification of NS1 dengue biomarker in serum via optomagnetic nanocluster detection.

Antunes, Paula, Watterson, Daniel, Parmvi, Mattias, Burger, Robert, Boisen, Anja, Young, Paul, Cooper, Matthew A., Hansen, Mikkel F., Ranzoni, Andrea and Donolato, Marco (2015). Quantification of NS1 dengue biomarker in serum via optomagnetic nanocluster detection.. Scientific Reports, 5 (16145) 16145, 1-10. doi: 10.1038/srep16145

Recent advances in the development of subunit-based RSV vaccines.

Jaberolansar, Noushin, Toth, Istvan, Young, Paul R. and Skwarczynski, Mariusz (2015). Recent advances in the development of subunit-based RSV vaccines.. Expert Review of Vaccines, 15 (1), 53-68. doi: 10.1586/14760584.2016.1105134

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Modhiran, Naphak, Watterson, Daniel, Muller, David A., Panetta, Adele K., Sester, David P., Liu, Lidong, Hume, David A., Stacey, Katryn J. and Young, Paul R. (2015). Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity. Science Translational Medicine, 7 (304) 304ra142, 1-10. doi: 10.1126/scitranslmed.aaa3863

The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation

Setoh, Yin Xiang, Tan, Cindy Si En, Prow, Natalie A., Hobson-Peters, Jody, Young, Paul R., Khromykh, Alexander A. and Hall, Roy A. (2015). The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation. Virology Journal, 12 (1) 72, 72.1-72.5. doi: 10.1186/s12985-015-0303-7

Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.

Young, Lucy B., Melian, Ezequiel Balmori, Setoh, Yin Xiang, Young, Paul R. and Khromykh, Alexander A. (2015). Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.. Journal of General Virology, 96 (5), 1042-1054. doi: 10.1099/vir.0.000053

Viral bacterial co-infection of the respiratory tract during early childhood

Brealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2015). Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiology Letters, 362 (10) fnv062. doi: 10.1093/femsle/fnv062

Resistance of Black-lip learl oyster, Pinctada margaritifera, to infection by Ostreid herpes virus 1(mu)var under experimental challenge may be mediated by humoral antiviral activity

Tan, Terence L. S., Paul-Pont, Ika, Evans, Olivia M., Watterson, Daniel, Young, Paul, Whittington, Richard, Fougerouse, Angelique, Bichet, Hervé, Barnes, Andrew C. and Dang, Cécile (2015). Resistance of Black-lip learl oyster, Pinctada margaritifera, to infection by Ostreid herpes virus 1(mu)var under experimental challenge may be mediated by humoral antiviral activity. Fish and Shellfish Immunology, 44 (1), 232-240. doi: 10.1016/j.fsi.2015.02.026

Recent advances in dengue pathogenesis and clinical management

Simmons, Cameron P., McPherson, Kirsty, Van Vinh Chau, Nguyen, Hoai Tam, D. T., Young, Paul, Mackenzie, Jason and Wills, Bridget (2015). Recent advances in dengue pathogenesis and clinical management. Vaccine, 33 (50), 7061-7068. doi: 10.1016/j.vaccine.2015.09.103

The contribution of non-human primate models to the development of human vaccines

Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.

Evaluation of direct versus multi-layer passivation and capture chemistries for nanoparticle-based biosensor applications

Sanjaya, K. C., Ranzoni, Andrea, Watterson, Daniel, Young, Paul and Cooper, Matthew A. (2014). Evaluation of direct versus multi-layer passivation and capture chemistries for nanoparticle-based biosensor applications. Biosensors and Bioelectronics, 67, 769-774. doi: 10.1016/j.bios.2014.09.048

Discovery of a novel retrovirus sequence in an Australian native rodent (Melomys burtoni): a putative link between Gibbon Ape Leukemia Virus and Koala Retrovirus

Simmons, Greg, Clarke, Daniel, McKee, Jeff, Young, Paul and Meers, Joanne (2014). Discovery of a novel retrovirus sequence in an Australian native rodent (Melomys burtoni): a putative link between Gibbon Ape Leukemia Virus and Koala Retrovirus. PLoS One, 9 (9) e106954, e106954.1-e106954.9. doi: 10.1371/journal.pone.0106954

A brief history of Australian microbiology

Young, Paul R. (2014). A brief history of Australian microbiology. Microbiology Australia, 35 (3), 121-123. doi: 10.1071/ma14047

Koala retrovirus (KoRV) and its variants

Young, Paul R. (2014). Koala retrovirus (KoRV) and its variants. Technical Reports of the Australian Museum, 24, 59-60. doi: 10.3853/j.1835-4211.24.2014.1617

The origins and ecological impact of koala retrovirus

Simmons, Greg, Meers, Joanne, Clarke, Daniel T. W., Young, Paul R., Jones, Kiersten, Hanger, Jon J., Loader, Jo and McKee, Jeff J. (2014). The origins and ecological impact of koala retrovirus. Technical Reports of the Australian Museum, Online, 24, 31-33. doi: 10.3853/j.1835-4211.24.2014.1610

Koala retroviruses: Characterization and impact on the life of koalas

Denner, Joachim and Young, Paul R. (2013). Koala retroviruses: Characterization and impact on the life of koalas. Retrovirology, 10 (1) 108, 108.1-108.7. doi: 10.1186/1742-4690-10-108

The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker

Muller, David A. and Young, Paul R. (2013). The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral research, 98 (2), 192-208. doi: 10.1016/j.antiviral.2013.03.008

Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children

Chappell, K.J., Brealey, J.C., Mackay, I.M., Bletchly, C., Hugenholtz, P., Sloots, T.P., Sly, P.D. and Young, P.R. (2013). Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children. Journal of Medical Microbiology & Diagnosis, S (1), 1-9. doi: 10.4172/2161-0703.S1-005

Prevalence of koala retrovirus in geographically diverse populations in Australia

Simmons, G. S., Young, P. R., Hanger, J. J., Jones, K., Clarke, D., McKee, J. J. and Meers, J. (2012). Prevalence of koala retrovirus in geographically diverse populations in Australia. Australian Veterinary Journal, 90 (10), 404-409. doi: 10.1111/j.1751-0813.2012.00964.x

Identification of residues in West Nile virus premembrane protein that influence viral particle secretion and virulence

Setoh, Y. X., Prow, N. A., Hobson-Peters, J., Lobigs, M., Young, P. R., Khromykh, A. A. and Hall, R. A. (2012). Identification of residues in West Nile virus premembrane protein that influence viral particle secretion and virulence. Journal of General Virology, 93 (Part 9), 1965-1975. doi: 10.1099/vir.0.044453-0

Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials

Simmons, Cameron P., Wolbers, Marcel, Minh Nguyet Nguyen, Whitehorn, Jamie, Shi, Pei Yong, Young, Paul, Petric, Rosemary, Van Vinh Chau Nguyen, Farrar, Jeremy and Wills, Bridget (2012). Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials. PLoS Neglected Tropical Diseases, 6 (9 Article No.e1752) e1752, e1752. doi: 10.1371/journal.pntd.0001752

A portable approach for the surveillance of dengue virus-infected mosquitoes

Muller, David A., Frentiu, Francesca D., Rojas, Alejandra, Moriero, Luciano A., O'Neill, Scott L. and Young, Paul R. (2012). A portable approach for the surveillance of dengue virus-infected mosquitoes. Journal of Virological Methods, 183 (1), 90-93. doi: 10.1016/j.jviromet.2012.03.033

Surface modified microprojection arrays for the selective extraction of the dengue virus NS1 protein as a marker for disease

Muller, David A., Corrie, Simon R., Coffey, Jacob, Young, Paul R. and Kendall, Mark A. (2012). Surface modified microprojection arrays for the selective extraction of the dengue virus NS1 protein as a marker for disease. Analytical Chemistry, 84 (7), 3262-3268. doi: 10.1021/ac2034387

Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis

Muller, David A., Landsberg, Michael J., Bletchly, Cheryl, Rothnagel, Rosalba, Waddington, Lynne, Hankamer, Ben and Young, Paul R. (2012). Structure of the dengue virus glycoprotein non-structural protein 1 by electron microscopy and single-particle analysis. Journal of General Virology, 93 (4), 771-779. doi: 10.1099/vir.0.039321-0

Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding

Watterson, Daniel, Kobe, Bostjan and Young, Paul R. (2012). Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding. Journal of General Virology, 93 (1), 72-82. doi: 10.1099/vir.0.037317-0

Expression of recombinant West Nile virus prM protein fused to an affinity tag for use as a diagnostic antigen

Setoh, Y. X., Hobson-Peters, J., Prow, N. A., Young, P. R. and Hall, R. A. (2011). Expression of recombinant West Nile virus prM protein fused to an affinity tag for use as a diagnostic antigen. Journal of Virological Methods, 175 (1), 20-27. doi: 10.1016/j.jviromet.2011.04.010

The epidemiology of Koala retrovirus

Simmons, Greg, Young, Paul, McKee, Jeff, Meers, Joanne and Mizuno, Tetsuo (2011). The epidemiology of Koala retrovirus. Juiekigaku Zasshi, 15 (1), 1-9. doi: 10.2743/jve.15.1

The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach

Fry, Scott R., Meyer, Michelle, Semple, Matthew G., Simmons, Cameron P., Sekaran, Shamala Devi, Huang, Johnny X., McElnea, Catriona, Huang, Chang-Yi, Valks, Andrea, Young, Paul R. and Cooper, Matthew A. (2011). The diagnostic sensitivity of dengue rapid test assays is significantly enhanced by using a combined antigen and antibody testing approach. PLoS Neglected Tropical Diseases, 5 (6) e1199, e1199.1-e1199.8. doi: 10.1371/journal.pntd.0001199

Kinetics of plasma viremia and soluble non-structural protein 1 concentrations in dengue: Differential effects according to serotype and immune status

Duyen, Huynh T. L., Ngoc, Tran V., Ha, Do Thi, Hang, Vu T. T., Kieu, Nguyen T. T., Young, Paul R., Farrar, Jeremy J., Simmons, Cameron P., Wolbers, Marcel and Wills, Bridget A. (2011). Kinetics of plasma viremia and soluble non-structural protein 1 concentrations in dengue: Differential effects according to serotype and immune status. Journal of Infectious Diseases, 203 (9), 1292-1300. doi: 10.1093/infdis/jir014

Wolbachia-Mediated Resistance to Dengue Virus Infection and Death at the Cellular Level

Frentiu, Francesca D., Robinson, Jodie, Young, Paul R., McGraw, Elizabeth A. and O'Neill, Scott L. (2010). Wolbachia-Mediated Resistance to Dengue Virus Infection and Death at the Cellular Level. PLoS One, 5 (10 Article # e13398.) e13398, 1-8. doi: 10.1371/journal.pone.0013398

The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity

Beltramello, Martina, Williams, Katherine L., Simmons, Cameron P., Macagno, Annalisa, Simonelli, Luca, Quyen, Nguyen Than Ha, Sukupolvi-Petty, Solia, Navarro-Sanchez, Erika, Young, Paul R., de Silva, Aravinda M., Rey, Felix A., Varani, Luca, Whitehead, Stephen S., Diamond, Michael S., Harris, Eva, Lanzavecchia, Antonio and Sallusto, Federica (2010). The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host and Microbe, 8 (3), 271-283. doi: 10.1016/j.chom.2010.08.007

Molecular phylogeny of edge hill virus supports its position in the yellow Fever virus group and identifies a new genetic variant

Macdonald, Joanne, Poidinger, Michael, Mackenzie, John S., Russell, Richard C., Doggett, Stephen, Broom, Annette K., Phillips, Debra, Potamski, Joseph, Gard, Geoff, Whelan, Peter, Weir, Richard, Young, Paul R., Gendle, Debra, Maher, Sheryl, Barnard, Ross T. and Hall, Roy A (2010). Molecular phylogeny of edge hill virus supports its position in the yellow Fever virus group and identifies a new genetic variant. Evolutionary Bioinformatics, 6, 91-96. doi: 10.4137/ebo.s4966

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Goméz, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni and Fairlie, David P. (2010). Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proceedings of the National Academy of Sciences of the United States of America, 107 (26), 11686-11691. doi: 10.1073/pnas.1002498107

Molecular phylogeny of Edge Hill virus supports its position in the yellow fever virus group and identifies a new genetic variant

Macdonald, Joanne, Poidinger, Michael, Mackenzie, John S., Russell, Richard C., Doggett, Stephen, Broom, Annette K., Phillips, Debra, Potamski, Joseph, Gard, Geoff, Whelan, Peter, Weir, Richard, Young, Paul R., Gendle, Debra, Maher, Sheryl, Barnard, Ross T. and Hall, Roy A. (2010). Molecular phylogeny of Edge Hill virus supports its position in the yellow fever virus group and identifies a new genetic variant. Evolutionary Bioinformatics, 6 (6), 91-96.

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

Kampmann, T., Yennamalli, R., Campbell, P., Stoermer, M. J., Fairlie, D. P., Kobe, B. and Young, P. R. (2009). In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Research, 84 (3), 234-241. doi: 10.1016/j.antiviral.2009.09.007

Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases

Stoermer, Martin J., Leung, Donmienne, Young, Paul R. and Fairlie, David P. (2009). Base-sensitivity of arginine alpha-ketoamide inhibitors of serine proteases. Australian Journal of Chemistry, 62 (9), 988-992. doi: 10.1071/CH09150

Identification of novel target sites and an inhibitor of the dengue virus E protein

Yennamalli, Ragothaman, Subbarao, Naidu, Kampmann, Thorsten, McGeary, Ross P., Young, Paul R. and Kobe, Bostjan (2009). Identification of novel target sites and an inhibitor of the dengue virus E protein. Journal of Computer-Aided Molecular Design, 23 (6), 333-341. doi: 10.1007/s10822-009-9263-6

Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation

Robin, Gautier, Chappell, Keith, Stoermer, Martin J., Hu, Shu-Hong, Young, Paul R., Fairlie, David P. and Martin, Jennifer L. (2009). Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation. Journal of Molecular Biology, 385 (5), 1568-1577. doi: 10.1016/j.jmb.2008.11.026

West Nile Virus NS2B/NS3 protease as an antiviral target

Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2008). West Nile Virus NS2B/NS3 protease as an antiviral target. Current Medicinal Chemistry, 15 (27), 2771-2784. doi: 10.2174/092986708786242804

Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

Stoermer, Martin J., Chappell, Keith J., Liebscher, Susann, Jensen, Christina M., Gan, Chun H., Gupta, Praveer K., Xu, Wei-Jun, Young, Paul R. and Fairlie, David P. (2008). Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity. Journal of Medicinal Chemistry, 51 (18), 5714-5721. doi: 10.1021/jm800503y

Virus invades the koala genome

Young, P. R., Tarlinton, R. E. and Meers, J. (2008). Virus invades the koala genome. Australasian Science, 29 (5), 30-31.

Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones

Young, Paul R., Anderton, Emma, Paschos, Kostas, White, Rob and Allday, Martin J. (2008). Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones. Journal of General Virology, 89 (4), 866-877. doi: 10.1099/vir.0.83414-0

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity

Chappell, Keith J., Stoermer, Martin J., Fairlie, David P. and Young, Paul R. (2008). Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. Journal of General Virology, 89 (4), 1010-1014. doi: 10.1099/vir.0.83447-0

A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases

Marcon, L., Kozak, D., Battersby, B.J., Chappell, K., Fairlie, D., Young, P.R. and Trau, M. (2008). A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases. Analytical Biochemistry, 2008 (376), 151-153. doi: 10.1016/j.ab.2008.01.034

Biology and evolution of the endogenous koala retrovirus

Tarlinton, Rachael Eugenie, Meers, Joanne and Young, Paul R. (2008). Biology and evolution of the endogenous koala retrovirus. Cellular and Molecular Life Sciences, 65 (21), 3413-3421. doi: 10.1007/s00018-008-8499-y

Histidine protonation and the activation of viral fusion proteins

Mueller, D., Kampmann, T., Yennamalli, R., Young, P.R., Kobe, B. and Mark, A. E. (2008). Histidine protonation and the activation of viral fusion proteins. Biochemical Society Transactions, 36 (1), 43-45. doi: 10.1042/BST0360043

Maternal antibody and viral factors in the pathogenesis of dengue virus in infants

Simmons, Cameron P., Chau, Tran Nguyen Bich, Thuy, Tran Thi, Tuan, Nguyen Minh, Hoang, Dang Minh, Thien, Nguyen Thanh, Lien, Le Bich, Quy, Nguyen Thien, Hieu, Nguyen Trong, Hien, Tran Tinh, McElnea, Catriona, Young, Paul, Whitehead, Steve, Hung, Nguyen Thanh and Farrar, Jeremy (2007). Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. Journal of Infectious Diseases, 196 (3), 416-424. doi: 10.1086/519170

Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3

Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022

Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery

Khoshnejad, M., Young, P. R., Toth, I. and Minchin, R. F. (2007). Modified Influenza Virosomes: Recent Advances and Potential in Gene Delivery. Current Medicinal Chemistry, 14 (29), 3152-3156. doi: 10.2174/092986707782793989

Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates

Gouvea, I. E, Izidoro, M. A, Judice, W. A. S, Cezari, M. H. S, Caliendo, G., Santagada, V., dos Santos, C. N. D, Queiroz, M. H, Juliano, M. A, Young, P. R, Fairlie, D. P and Juliano, L. (2007). Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Archives of Biochemistry and Biophysics, 457 (2), 187-196. doi: 10.1016/j.abb.2006.11.005

SwarmPS: Rapid, semi-automated single particle selection software

Woolford, D. S., Ericksson, G. B., Rothnagel, R., Muller, D., Landsberg, M. J., Pantelic, R., McDowall, A. W., Pailthorpe, B., Young, P. R., Hankamer, B. and Banks, J. (2007). SwarmPS: Rapid, semi-automated single particle selection software. Journal of Structural Biology, 157 (1), 174-188. doi: 10.1016/j.jsb.2006.04.006

The discriminative bilateral filter: An enhanced denoising filter for electron microscopy data

Pantelic, R. S., Rothnagel, A. R., Huang, C. Y., Muller, D. A., Woolford, D., Landsberg, M. J., McDowall, A. W., Pailthorpe, B., Young, P. R., Banks, J. E., Hankamer, B. and Ericksson, G. B. (2006). The discriminative bilateral filter: An enhanced denoising filter for electron microscopy data. Journal Of Structural Biology, 155 (3), 395-408. doi: 10.1016/j.jsb.2006.03.030

Retroviral invasion of the koala genome

Tarlinton, R. E., Meers, J. and Young, P. R. (2006). Retroviral invasion of the koala genome. Nature, 442 (7098), 79-81. doi: 10.1038/nature04841

Current Status of Short Synthetic Peptides as Vaccines

Hans, D., Young, P. R. and Fairlie, D. (2006). Current Status of Short Synthetic Peptides as Vaccines. Medicinal Chemistry, 2 (6), 627-646. doi: 10.2174/1573406410602060627

Human metapneumovirus, Australia, 2001-2004

Sloots, T. P., Mackay, I. M., Bialasiewicz, S., Jacob, K. C., McQueen, E., Harnett, G. B., Siebert, D. J., Masters, I. B., Young, P. R. and Nissen, M. D. (2006). Human metapneumovirus, Australia, 2001-2004. Emerging Infectious Diseases, 12 (8), 1263-1266. doi: 10.3201/eid1708.051239

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies

Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus

Shepherd, Nicholas E., Hoang, Huy N., Desai, Vishal S., Letouze, Eric, Young, Paul R. and Fairlie, David P. (2006). Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus. Journal of The American Chemical Society, 128 (40), 13284-13289. doi: 10.1021/ja064058a

The role of histidine residues in low-pH-mediated viral membrane fusion

Kampmann, Thorsten, Meuller, Daniela S., Mark, Alan E., Young, Paul R. and Kobe, Bostjan (2006). The role of histidine residues in low-pH-mediated viral membrane fusion. Structure, 14 (10), 1481-1487. doi: 10.1016/j.str.2006.07.011

Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas

Tarlinton, Rachael, Meers, Joanne, Hanger, Jon and Young, Paul (2005). Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas. Journal of General Virology, 86 (3), 783-787. doi: 10.1099/vir.0.80547-0

Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions

Chappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200

Effects of simvastatin on blood lipids, vitamin E, coenzyme Q(10) levels and left ventricular function in humans

Colquhoun, D. M., Jackson, R., Walters, M., Hicks, B. J., Goldsmith, J., Young, P., Strakosch, C. and Kostner, K. M. (2005). Effects of simvastatin on blood lipids, vitamin E, coenzyme Q(10) levels and left ventricular function in humans. European Journal of Clinical Investigation, 35 (4), 251-258. doi: 10.1111/j.1365-2362.2005.01486.x

Emerging threats to the blood supply: West Nile virus and beyond

Young, P. R. (2005). Emerging threats to the blood supply: West Nile virus and beyond. Microbiology Australia, 2005 (March), 6-9.

Determination of the disulfide bond arrangement of dengue virus NS1 protein

Wallis, T. P., Huang, C. Y., Nimkar, S. B., Young, P. R. and Gorman, J. J. (2004). Determination of the disulfide bond arrangement of dengue virus NS1 protein. Journal of Biological Chemistry, 279 (20), 20729-20741. doi: 10.1074/jbc.M312907200

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

Nall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200

Dengue vaccines: Preparing to roll back dengue

Jacobs, M. and Young, P. R. (2003). Dengue vaccines: Preparing to roll back dengue. Current Opinion in Investigational Drugs, 4 (2), 168-171.

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay

Morton, C. J., Cameron, R., Lawrence, L. J., Lin, B., Lowe, M., Luttick, A., Mason, A., McKimm-Breschkin, J., Parker, M. W., Ryan, J., Smout, M., Sullivan, J, Tucker, S. P. and Young, P. R. (2003). Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology, 311 (2), 275-288. doi: 10.1016/S0042-6822(03)00115-6

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever

Libraty, Daniel H., Young, Paul R., Pickering, Darren, Endy, Timothy P., Kalayanarooj, Siripen, Green, Sharone, Vaughn, David W., Nisalak, Ananda, Ennis, Francis A. and Rothman, Alan L. (2002). High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. Journal of Infectious Diseases, 186 (8), 1165-1168. doi: 10.1086/343813

Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography

Arakaki, T. L., Fang, N. X., Fairlie, D. P., Young, P. R. and Martin, J. L. (2002). Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography. Protein Expression And Purification, 25 (2), 241-247. doi: 10.1016/S1046-5928(02)00005-0

Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone

Chan, Leslie C. L., Young, Paul R., Bletchly, Cheryl and Reid, Steven (2002). Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone. Journal of Virological Methods, 105 (1), 87-98. doi: 10.1016/S0166-0934(02)00084-8

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors

Leung, D., Schroder, K., White, H., Fang, N. X., Stoermer, M. J., Abbenante, G., Martin, J. L., Young, P. R. and Fairlie, D. P. (2001). Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry, 276 (49), 45762-45771. doi: 10.1074/jbc.M107360200

Bats and viruses - a long association

Halpin, K., Young, P. and Mackenzie, J. S. (2001). Bats and viruses - a long association. American Journal of Tropical Medicine & Hygiene, 65, 249-249.

Widespread promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa

Herath, N. I., Kew, M. C., Smith, G., Young, J. P., Powell, L. W., Leggett, B. A. and Macdonald, G. A. (2001). Widespread promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa. Hepatology, 34 (4, Part 2 Suppl.), 667A-667A.

Dengue virus non-structural protein 1 is expressed in a glycosyl-phosphatidylinositol linked form that is capable of signal transduction

Jacobs, Michael G., Robinson, Peter J., Bletchly, Cheryl, Mackenzie, Jason M. and Young, Paul R. (2000). Dengue virus non-structural protein 1 is expressed in a glycosyl-phosphatidylinositol linked form that is capable of signal transduction. The FASEB Journal, 14 (11), 1603-1610. doi: 10.1096/fj.14.11.1603

Stable High-Level Expression of Heterologous Genes In Vitro and In Vivo by Noncytopathic DNA-Based Kunjin Virus Repicon Vectors

Varnavski, Andrei N., Young, Paul R. and Khromykh, Alexander A. (2000). Stable High-Level Expression of Heterologous Genes In Vitro and In Vivo by Noncytopathic DNA-Based Kunjin Virus Repicon Vectors. Journal of Virology, 74 (9), 4394-4403. doi: 10.1128/JVI.74.9.4394-4403.2000

An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients

Young, Paul R., Hilditch, Paige A., Bletchly, Cheryl and Halloran, Wendy (2000). An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients. Journal of Clinical Microbiology, 38 (3), 1053-1057. doi: 10.1128/jcm.38.3.1053-1057.2000

Monodon baculovirus from Australia: Ultrastructural observations

Vickers, J. E., Webb, R. and Young, P. R. (2000). Monodon baculovirus from Australia: Ultrastructural observations. Diseases of Aquatic Organisms, 39 (3), 169-176. doi: 10.3354/dao039169

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

Brinkworth, R. I., Fairlie, D., Leung, D. and Young, P. R. (1999). Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.. Journal of General Virology, 80 (5), 1167-1177. doi: 10.1099/0022-1317-80-5-1167

Colourimetric PCR-based detection of monodon baculovirus in whole Penaeus monodon postlarvae

Belcher, CR and Young, PR (1998). Colourimetric PCR-based detection of monodon baculovirus in whole Penaeus monodon postlarvae. Journal of Virological Methods, 74 (1), 21-29. doi: 10.1016/S0166-0934(98)00067-6

Dengue: a continuing challenge for molecular biology

Jacobs, MG and Young, PR (1998). Dengue: a continuing challenge for molecular biology. Current Opinion in Infectious Diseases, 11 (3), 319-324. doi: 10.1097/00001432-199806000-00009

Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication

Mackenzie, JM, Jones, MK and Young, YR (1996). Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication. Virology, 220 (1), 232-240. doi: 10.1006/viro.1996.0307

Improved membrane preservation of flavivirus-infected cells with cryosectioning

Mackenzie, JM, Jones, MK and Young, PR (1996). Improved membrane preservation of flavivirus-infected cells with cryosectioning. Journal of Virological Methods, 56 (1), 67-75. doi: 10.1016/0166-0934(95)01916-2

Maturation of the Dengue-2 Virus Ns1 Protein in Insect Cells - Effects of Downstream Ns2a Sequences On Baculovirus-Expressed Gene Constructs

Leblois, H and Young, PR (1995). Maturation of the Dengue-2 Virus Ns1 Protein in Insect Cells - Effects of Downstream Ns2a Sequences On Baculovirus-Expressed Gene Constructs. Journal of General Virology, 76 (4), 979-984. doi: 10.1099/0022-1317-76-4-979

Optimization of Pcr and Automated Sequencing of Clinical Isolates of Respiratory Syncytial Virus

Meteyard, JD and Young, PR (1994). Optimization of Pcr and Automated Sequencing of Clinical Isolates of Respiratory Syncytial Virus. Journal of Virological Methods, 50 (1-3), 335-341. doi: 10.1016/0166-0934(94)90188-0

Precise Location of Sequential Dengue Virus Subcomplex and Complex B-Cell Epitopes On the Nonstructural-1 Glycoprotein

Falconar, Aki, Young, PR and Miles, MA (1994). Precise Location of Sequential Dengue Virus Subcomplex and Complex B-Cell Epitopes On the Nonstructural-1 Glycoprotein. Archives of Virology, 137 (3-4), 315-326. doi: 10.1007/BF01309478

Sequence of the Dengue Virus Type-2 (strain Pr-159) Ns1 Gene and Comparison with its Vaccine Derivative

Leblois, H and Young, PR (1993). Sequence of the Dengue Virus Type-2 (strain Pr-159) Ns1 Gene and Comparison with its Vaccine Derivative. Nucleic Acids Research, 21 (7), 1668-1668. doi: 10.1093/nar/21.7.1668

Use of Recombinant Fusion Proteins and Monoclonal-Antibodies to Define Linear and Discontinuous Antigenic Sites On the Dengue Virus Envelope Glycoprotein

Megret, F, Hugnot, JP, Falconar, A, Gentry, MK, Morens, DM, Murray, JM, Schlesinger, JJ, Wright, PJ, Young, P, Vanregenmortel, Mhv and Deubel, V (1992). Use of Recombinant Fusion Proteins and Monoclonal-Antibodies to Define Linear and Discontinuous Antigenic Sites On the Dengue Virus Envelope Glycoprotein. Virology, 187 (2), 480-491. doi: 10.1016/0042-6822(92)90450-4

Production of Dimer-Specific and Dengue Virus Group Cross-Reactive Mouse Monoclonal-Antibodies to the Dengue-2 Virus Nonstructural Glycoprotein Ns1

Falconar, Aki and Young, PR (1991). Production of Dimer-Specific and Dengue Virus Group Cross-Reactive Mouse Monoclonal-Antibodies to the Dengue-2 Virus Nonstructural Glycoprotein Ns1. Journal of General Virology, 72 (4), 961-965. doi: 10.1099/0022-1317-72-4-961

Antigenic analysis of dengue virus using monoclonal antibodies

Young, P. R. (1990). Antigenic analysis of dengue virus using monoclonal antibodies. The Southeast Asian journal of tropical medicine and public health, 21 (4), 646-651.

Immunoaffinity Purification of Native Dimer Forms of the Flavivirus Nonstructural Glycoprotein, Ns1

Falconar, Aki and Young, PR (1990). Immunoaffinity Purification of Native Dimer Forms of the Flavivirus Nonstructural Glycoprotein, Ns1. Journal of Virological Methods, 30 (3), 323-332. doi: 10.1016/0166-0934(90)90075-Q

Trypanosoma-Cruzi Infection in the Mexican State of Guerrero - a Seroepidemiological (Elisa) Survey of 20 Communities

Andersson, N, Morales, A, Nava, E, Martinez, E, Rodriguez, I, Young, P, Howard, MK and Miles, MA (1990). Trypanosoma-Cruzi Infection in the Mexican State of Guerrero - a Seroepidemiological (Elisa) Survey of 20 Communities. Journal of Tropical Medicine and Hygiene, 93 (5), 341-346.

Enhancement of Immunoblot Staining Using a Mixed Chromogenic Substrate

Young, PR (1989). Enhancement of Immunoblot Staining Using a Mixed Chromogenic Substrate. Journal of Immunological Methods, 121 (2), 295-296. doi: 10.1016/0022-1759(89)90174-9

An Improved Method for the Detection of Peroxidase-Conjugated Antibodies On Immunoblots

Young, PR (1989). An Improved Method for the Detection of Peroxidase-Conjugated Antibodies On Immunoblots. Journal of Virological Methods, 24 (1-2), 227-235. doi: 10.1016/0166-0934(89)90025-6

Localization of An Arenavirus Protein in the Nuclei of Infected-Cells

Young, PR, Chanas, AC, Lee, SR, Gould, EA and Howard, CR (1987). Localization of An Arenavirus Protein in the Nuclei of Infected-Cells. Journal of General Virology, 68 (9), 2465-2470. doi: 10.1099/0022-1317-68-9-2465

Hepatitis-B Surface-Antigen Polypeptide Micelles From Antigen Expressed in Saccharomyces-Cerevisiae

Howard, CR, Young, PR, Lee, S, Dixon, J, Zuckerman, AJ, McAleer, WJ and Lehman, ED (1986). Hepatitis-B Surface-Antigen Polypeptide Micelles From Antigen Expressed in Saccharomyces-Cerevisiae. Journal of Virological Methods, 14 (1), 25-35. doi: 10.1016/0166-0934(86)90004-2

RIBONUCLEOPROTEIN COMPLEXES ASSOCIATED WITH VIRIONS OF PICHINDE VIRUS AND PICHINDE VIRUS-INFECTED CELLS

YOUNG, PR and HOWARD, CR (1986). RIBONUCLEOPROTEIN COMPLEXES ASSOCIATED WITH VIRIONS OF PICHINDE VIRUS AND PICHINDE VIRUS-INFECTED CELLS. Medical Microbiology and Immunology, 175 (2-3), 79-83. doi: 10.1007/BF02122420

Development of Novel Hepatitis-B Vaccines

Howard, CR, Young, P, Steward, MW and Zuckerman, AJ (1985). Development of Novel Hepatitis-B Vaccines. Developments in Biological Standardization, 59, 89-98.

Characterization of Nugget Virus, a Serotype of the Kemerovo Group of Orbiviruses

Gorman, BM, Taylor, J, Morton, HC, Melzer, AJ and Young, PR (1984). Characterization of Nugget Virus, a Serotype of the Kemerovo Group of Orbiviruses. Australian Journal of Experimental Biology and Medical Science, 62 (FEB), 101-115. doi: 10.1038/icb.1984.10

Variation Among New and Old-World Arenaviruses

Howard, CR and Young, PR (1984). Variation Among New and Old-World Arenaviruses. Transactions of the Royal Society of Tropical Medicine and Hygiene, 78 (3), 299-306. doi: 10.1016/0035-9203(84)90101-9

Chemical Inactivation of Hepatitis-B Virus - the Effect of Disinfectants On Virus-Associated Dna-Polymerase Activity, Morphology and Infectivity

Howard, CR, Dixon, J, Young, P, Vaneerd, P and Schellekens, H (1983). Chemical Inactivation of Hepatitis-B Virus - the Effect of Disinfectants On Virus-Associated Dna-Polymerase Activity, Morphology and Infectivity. Journal of Virological Methods, 7 (3), 135-148. doi: 10.1016/0166-0934(83)90003-4

Fine-Structure Analysis of Pichinde Virus Nucleocapsids

Young, PR and Howard, CR (1983). Fine-Structure Analysis of Pichinde Virus Nucleocapsids. Journal of General Virology, 64 (APR), 833-842. doi: 10.1099/0022-1317-64-4-833

Preparation of Hepatitis-B Polypeptide Micelles From Human Carrier Plasma

Young, P, Vaudin, M, Dixon, J and Zuckerman, AJ (1982). Preparation of Hepatitis-B Polypeptide Micelles From Human Carrier Plasma. Journal of Virological Methods, 4 (3), 177-185. doi: 10.1016/0166-0934(82)90046-5

Evaluation of Plaque Size-Reduction as a Method for the Detection of Pichinde Virus-Antibody

Chanas, AC, Young, PR, Ellis, DS, Mann, G, Stamford, S and Howard, CR (1980). Evaluation of Plaque Size-Reduction as a Method for the Detection of Pichinde Virus-Antibody. Archives of Virology, 65 (2), 157-167. doi: 10.1007/BF01317327

Isolation of Recombinants Between Related Orbiviruses

Gorman, BM, Taylor, J, Walker, PJ and Young, PR (1978). Isolation of Recombinants Between Related Orbiviruses. Journal of General Virology, 41 (NOV), 333-342. doi: 10.1099/0022-1317-41-2-333

Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019

Helbig, Karla J., Bull, Rowena A., Ambrose, Rebecca, Beard, Michael R., Blanchard, Helen, Böcking, Till, Chua, Brendon, Colmant, Agathe M. G., Crosse, Keaton M., Purcell, Damian F. J., Fraser, Johanna, Hayward, Joshua A., Hamilton, Stuart T., Husain, Matloob, MacDiarmid, Robin, Mackenzie, Jason M., Moseley, Gregory W., Nguyen, Thi H O, Quiñones-Mateu, Miguel E., Robinson, Karl, Rodrigo, Chaturaka, Rodriguez-Andres, Julio, Rudd, Penny A., Werno, Anja, White, Peter, Young, Paul, Speck, Peter, Hibma, Merilyn, Drummer, Heidi E. and Tachedjian, Gilda (2020). Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019. Tenth Scientific Biennial Meeting of the Australasian Virology Society, Queenstown, New Zealand, 2–5 December 2019. Basel, Switzerland: M D P I AG. doi: 10.3390/v12060621

Communication Ambassadors – An Australian Outreach Initiative for Early Career Scientists

Wang, Jack T.H., Power, Cheryl J., Kahler, Charlene M., Lyras, Dena, Young, Paul R., Iredell, Jonathan and Robins-Browne, Roy (2018). Communication Ambassadors – An Australian Outreach Initiative for Early Career Scientists. ASM Conference for Undergraduate Educators, Austin, TX United States, 26-29 July 2018.

Targeted delivery of candidate dengue virus subunit vaccine to the skin using the Nanopatch™

Muller, D. A., Depelsenaire, A. C. I., Watterson, D., Zhang, J., Yukiko, S. R., Young, P. R. and Kendall, M. A. F. (2014). Targeted delivery of candidate dengue virus subunit vaccine to the skin using the Nanopatch™. Vaccine Technology V, Playa del Carmen, Mexico, 8-13 June 2014.

Novel inhibitors of DENV NS2B/NS3pro protease

Chow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC.

Nanopatch delivery of a tetravalent recombinant subunit dengue vaccine

Depelsenaire, Alexandra C. I., Watterson, Daniel, Zhang, Jin, Yukiko, Sally, Young, Paul R., Kendall, Mark A. F. and Muller, David A. (2013). Nanopatch delivery of a tetravalent recombinant subunit dengue vaccine. Australasian Virology Society Meeting 2013, Queenstown, New Zealand, 8-11 December 2013.

The effect of pathogen reduction technology (mirasol) on the infectivity of Denuge viruses

Faddy, H., Fryk, J., Young, P., Watterson, D., Goodrich, R. and Marks, D. (2012). The effect of pathogen reduction technology (mirasol) on the infectivity of Denuge viruses. 32nd International Congress of the International Society of Blood Transfusion in joint cooperation with the 10th Congress of AMMTAC, Cancun, Mexico, 7-12 July 2012. Oxford, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/j.1423-0410.2012.01615_2.x

Characterisation of a novel retrovirus in a native Australian rodent and its potential link to Koala retrovirus (KoRV)

Clarke, D. T. W., Simmons, G., Fowler, E., Meers, J. and Young, P. R. (2010). Characterisation of a novel retrovirus in a native Australian rodent and its potential link to Koala retrovirus (KoRV). 22nd Workshop on Retroviral Pathogenesis., California, United States, 17-21 November 2010.

Evaluation of a rapid assay for detection of dengue early marker nonstructural protein 1 (ns1)

Fry, Scott, Semple, Matthew, Meyer, Michelle, McElnea, Catriona, Young, Paul, Valks, Andrea and Huang, Chang-Yi (Charlie) (2010). Evaluation of a rapid assay for detection of dengue early marker nonstructural protein 1 (ns1). 59th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), Atlanta, GA, U.S.A., 3-7 November 2010. United States: American Society of Tropical Medicine and Hygiene.

Potent inhibitors of West Nile Virus NS2B/NS3 protease

Chappell, K. J., Fairlie, D. P., Gan, C. H., Gupta, P. K., Hu, S., Jensen, C. M., Liebscher, S., Martin, J. L., Robin, G., Stoermer M. J., Xu, W. and Young, P. R. (2010). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009. Berlin, Germany: Walter De Gruyter.

Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates

Liebscher, Susan, Chappell, K. J., Stoermer, Martin J., Watterson, Daniel, Webb, Richard I., Khromykh, Alexander A., Fairlie, David P. and Young, Paul R. (2010). Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates. PlusStrand 2010: The Ninth International Symposium on Positive-Strand RNA Viruses, Atlanta, GA, U.S.A., 17-21 May 2010.

Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 protease

Liebscher, S., Chappell, K.J., Stoermer, M.J., Fairlie, D.P. and Young, P.R (2009). Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast , QLD, Australia, 26-30 October, 2009.

Dengue viral envelope protein and histidine protonation

Yennamalli, RM, Kobe, B, Mark, AE, Young, PR and Subbarao, N (2009). Dengue viral envelope protein and histidine protonation. XVIII National Conference of Indian Virological Society, Post Graduate Institute of Medical Education and Research, Chandigarh, India., 11–13 December 2008. HISAR: Indian Virological Society.

Prevalence of Koala retrovirus in wild koalas in Australia

Simmons, G., Meers, J. and Young, P. (2008). Prevalence of Koala retrovirus in wild koalas in Australia. 20th International Workshop on Retroviral Pathogenesis, Toronto, Canada, 12–16 November 2008.

Discussion

Jans, David A., Satchidanandam, Vijaya, Young, Paul, Padmanabhan, R. Pad, Screaton, Gavin, Harris, Eva, Lee, Mary Ng Mah and Rice, Charles (2006). Discussion.

Discussion

Canard, Bruno, Lescar, Julien, Vasudevan, Subhash, Kuhn, Richard, Rice, Charles, Satchidanandam, Vijaya, Young, Paul, Gamarnik, Andrea, Padmanabhan, R. Pad and Keller, Thomas (2006). Discussion.

Discussion

Harris, Eva, Screaton, Gavin, Farrar, Jeremy, Hombach, Joachim, Halstead, Scott, Rice, Charles, Holmes, Edward, Satchidanandam, Vijaya, Young, Paul, Zinkernagel, Rolf, Flamand, Marie, Malasit, Prida and Fairlie, David (2006). Discussion. Novartis Foundation.

Discussion

Rice, Charles, Heinz, Franz X., Kuhn, Richard, Harris, Eva, Fairlie, David, Young, Paul, Flamand, Marie, Zinkernagel, Rolf, Halstead, Scott, Evans, Thomas G., Jans, David A. and Screaton, Gavin (2006). Discussion.

Discussion

Young, Paul, Keller, Thomas, Padmanabhan, R. Pad, Fairlie, David, Hibberd, Martin, Rice, Charles, Canard, Bruno, Vasudevan, Subhash, Screaton, Gavin, Harris, Eva, Gu, Feng, Halstead, Scott, Farrar, Jeremy, Holmes, Edward, Malasit, Prida and Evans, Thomas G. (2006). Discussion. Novartis Foundation.

General discussion I

Rice, Charles, Heinz, Franz X., Young, Paul, Kuhn, Richard, Neyts, Johan, Keller, Thomas, Fairlie, David, Guber, Duane J. and Screaton, Gavin (2006). General discussion I.

A dangerous inheritance: Retroviral invasion of the koala genome.

Young, P. R., Tarlinton, R. E. and Meers, J. (2006). A dangerous inheritance: Retroviral invasion of the koala genome.. Workshop on endogenous retroviruses and retroelements, Mystic, USA, 7-9 Sept, 2006.

A novel infection-dependent replicon system to deliver ribozymes targeting respiratory syncytial virus

Meyer, M. N., Easton, A. and Young, P R (2006). A novel infection-dependent replicon system to deliver ribozymes targeting respiratory syncytial virus. 13th International Conference of Negative Strand Viruses, Salamanca, 17-22 June, 2006.

A self-regulating system for the delivery of ribozymes targeting respiratory syncytial virus in vitro

Meyer, M. N., Easton, A. and Young, P. R. (2006). A self-regulating system for the delivery of ribozymes targeting respiratory syncytial virus in vitro. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, 2-6 July, 2006.

Bridging the gap in early diagnosis of dengue infection

Young, P. R., McElnea, C. L., Hafner, G. J., Simmons, C., Tran, N., Nguyen, T. T. and Dang, M. H. (2006). Bridging the gap in early diagnosis of dengue infection. 7th Asia Pacific Congress of Virology, New Delhi, India, 13-15 November, 2006.

Codon optimisation and synthesis of dengue 2 pre-membrane and envelope proteins (prM and E) for characterisation of molecular mehanisms of viral receptor binding and entry

Campbell, P. and Young, P. R. (2006). Codon optimisation and synthesis of dengue 2 pre-membrane and envelope proteins (prM and E) for characterisation of molecular mehanisms of viral receptor binding and entry. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast. Qld, 2-6 July, 2006.

Developing antiviral targets for RSV via mutational analysis of HRB and HRC domains using a novel fusion assay system

Desai, A., Khlentzos, A., Shepherd, N., Hoang, H. N., Letouze, E., Fairlie, D. and Young, P. R. (2006). Developing antiviral targets for RSV via mutational analysis of HRB and HRC domains using a novel fusion assay system. 13th International Conference of Negative Strand Viruses, Salamanca, 17-22 June, 2006.

Development and characterization of a novel signal peptide for baculorvirus protein production

Muller, D. A. and Young, P. R. (2006). Development and characterization of a novel signal peptide for baculorvirus protein production. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

Development of a novel dengue virus binding assay using a recombinant sub-domain of E in a live cell LISA format

Watterson, D. and Young, P. R. (2006). Development of a novel dengue virus binding assay using a recombinant sub-domain of E in a live cell LISA format. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

Discussion

Evans, Thomas G., Holmes, Edward, Young, Paul, Gubler, Duane J., Harris, Eva, Halstead, Scott, Padmanabhan, R. Pad, Rice, Charles, Canard, Bruno, Lee, Mary Ng Mah, Farrar, Jeremy, Satchidanandam, Vijaya and Herrling, Paul (2006). Discussion. Novartis Foundation Symposium 277, Singapore, Singapore, 26 - 27 September 2005. Novartis Foundation.

Discussion

Harris, Eva, Flamand, Marie, Canard, Bruno, Stephenson, John, Farrar, Jeremy, Zinkernagel, Rolf, Satchidanandam, Vijaya, Malasit, Prida, Vasudevan, Subhash, Young, Paul, Padmanabhan, R. Pad and Keller, Thomas (2006). Discussion. Novartis Foundation Symposium 277: New treatment strategies for Dengue and other flaviviral diseases, *, 2006. John Wiley & Sons.

Discussion

Harris, Eva, Kuhn, Richard, Heinz, Franz X., Gamarnik, Andrea, Screaton, Gavin, Jans, David A., Keller, Thomas, Young, Paul, Zinkernagel, Rolf, Flamand, Marie, Lescar, Julien, Stephenson, John and Gu, Feng (2006). Discussion. Novartis Foundation Symposium 277: New treatment strategies for Dengue and other flaviviral diseases, *, 2006. John Wiley & Sons.

Effects of NS2A downsteam sequences in cleavage of the NS1.NS2A junction of dengue virus

Liebscher, S. and Young, P R (2006). Effects of NS2A downsteam sequences in cleavage of the NS1.NS2A junction of dengue virus. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

Final discussion

Ng Mah Lee, Mary, Rice, Charles, Fairlie, David, Zinkernagel, Rolf, Young, Paul, Neyts, Johan, Hibberd, Martin, Holmes, Edward, Heinz, Franz X. and Stephenson, John (2006). Final discussion. Novartis Foundation Symposium 277: New treatment strategies for Dengue and other flaviviral diseases, *, 2006. John Wiley & Sons.

Flavivirus targets for antiviral drug design

Young, P. R. (2006). Flavivirus targets for antiviral drug design. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

Flavivirus targets in antiviral drug design

Young, P. R. (2006). Flavivirus targets in antiviral drug design. 4th Symposium of the International Consortium on Anti-Virals, Gold Coast, Qld, 22-25 Sept, 2006.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B. and Young, P. R. (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 5th International Conference on Bioinformatics, New Delhi, India, 18-20 Dec, 2006.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R, R., Kampmann, T., Subbarao, N., Kobe, B and Young, P R (2006). In silico screening and structure based drug design for the envelope protein of flaviviruses. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modification

Chappell, K. J., Stoermer, M J, Fairlie, D and Young, P R (2006). Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modification. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

Koala Retrovirus: Search for an ancestor virus and investigation of disease associations

Simmons, G . S., Tarlinton, R. E., Young, P. R. and Meers, J. (2006). Koala Retrovirus: Search for an ancestor virus and investigation of disease associations. Veterinary Virology Conference 2006, BIO21 Institute, Melbourne University, 27-29th September 2006. Melbourne, Vic.: The University of Melbourne.

Modified influenza virosomes for gene delivery

Khoshnejad, M., Toth, I., Young, P. R. and Minchin, R. F. (2006). Modified influenza virosomes for gene delivery. Brisbane Biological & Organic Chemistry Symposium, Brisbane, Qld, 24 Nov 2006.

Molecular characterization of the dengue virus non-structural protein 1 membrane association

Panetta, A. K. and Young, P R (2006). Molecular characterization of the dengue virus non-structural protein 1 membrane association. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, QLD., 2-6 July, 2006.

Multiple targets for antiviral inhibitors

Young, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006.

RSV fusion protein expression and optimization in insect cells

Desai, V., Huang, C. and Young, P R (2006). RSV fusion protein expression and optimization in insect cells. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006.

The mechanism of vira membrane fusion and identification of novel antiviral lead compounds

Kampmann, T., Muller,, Robinson, J., Mark, A, Young, P R and Kobe, B (2006). The mechanism of vira membrane fusion and identification of novel antiviral lead compounds. 31st Lorne Conference on Protein Structure & Function, Lorne, Victoria, Australia, 5-9 Feb, 2006.

A self regulating system for the delivery of ribozymes targeting Respiratory Syncytial Virus in vitro

Meyer, M. N., Easton, A. and Young, P. R. (2005). A self regulating system for the delivery of ribozymes targeting Respiratory Syncytial Virus in vitro. 3rd Australian Virology Group Meeting, Phillip Is, 9-12 Dec, 2005.

A structural model for low pH mediated viral fusion: The role of histidine protonation

Kampmann, T., Muller, D. A., Robinson, J., Mark, A., Young, P. R. and Kobe, B. (2005). A structural model for low pH mediated viral fusion: The role of histidine protonation. 3rd Australian Virology Group Meeting, Phillip Island, 9-12 Dec, 2005.

Codon optimisation and synthesis of dengue 2 pre-membrane and evelope proteins (prM and E) for characterisation of molecular mechanisms of viral receptor binding and entry

Campbell, P. and Young, P. R. (2005). Codon optimisation and synthesis of dengue 2 pre-membrane and evelope proteins (prM and E) for characterisation of molecular mechanisms of viral receptor binding and entry. 3rd Australian Virology Group Meeting, Phillip Island, Vic., 9-12 December, 2005.

Dengue virus mediated fusion as a target for antiviral drug design

Young, P. R., Robinson, J., Kampmann, T. and Kobe, B. (2005). Dengue virus mediated fusion as a target for antiviral drug design. 2nd Asian Dengue Meeting, Singapore, 28-30 Sept, 2005.

Development and characterisation of a novel signal peptide for baculovirus protein production

Muller, D. A., Huang, C. and Young, P. R. (2005). Development and characterisation of a novel signal peptide for baculovirus protein production. 3rd Australian Virology Group Mtg, Phillip Is, 9-12 Dec, 2005.

Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis

Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.

Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis

Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile NS3 protease and the identification of key enzyme-substrate interactions by site-directed mutagenesis. International Congress of Virology, San Francisco, 23-27 July, 2005.

Development of a catalytically active recombinant West Nile virus NS3 protease and the identification of key enzyme-substrate and enzyme-cofactor interactions by site-directed mutagenesis

Chappell, K. J., Stoermer, M. J., Fairlie, D. and Young, P. R. (2005). Development of a catalytically active recombinant West Nile virus NS3 protease and the identification of key enzyme-substrate and enzyme-cofactor interactions by site-directed mutagenesis. 3rd Australian Virology Group Meeting, Phillip Island, Vic., 9-12 Dec, 2005.

Development of a novel dengue virus binding assay using a recombinant sub-domain of E in a live cell ELISA format

Watterson, D. and Young, P. R. (2005). Development of a novel dengue virus binding assay using a recombinant sub-domain of E in a live cell ELISA format. 3rd Australian Virology Group Meeting, Phillip Island, 9-12 December, 2005.

Development of antiviral drugs targeting the flavivirus fusion mechanism

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Development of antiviral drugs targeting the flavivirus fusion mechanism. 30th Lorne Conference on Protein Structure & Function, Lorne, 6-10 Feb, 2005.

Development of antiviral drugs targeting the flaviviruses fusion mechanism

Kampmann, T., Yennamalli, R., Stoermer, M., Kobe, B. and Young, P. (2005). Development of antiviral drugs targeting the flaviviruses fusion mechanism. 30th FEBS Congress - 9th IUBMB Conference, Budapest, Hungary, 2-7tJuly 2005. Oxford, England: Blackwell Publishing. doi: 10.1111/j.1742-4658.2005.4739_15.x

Discovery of antiviral inhibitors targeting the fusion mechanism of the flavivirus family members Dengue, Kunjin and Yellow fever

Kampmann, T., Yennamalli Madhava R, R., Stoermer, M. J., Kobe, B. and Young, P. R. (2005). Discovery of antiviral inhibitors targeting the fusion mechanism of the flavivirus family members Dengue, Kunjin and Yellow fever. 30th FEBS Congress - 9th Int Union of Biochem & Molecular Biof, Budapest, 2-7 July, 2005.

In silico screening and structure based drug design for the envelope protein of flaviviruses

Yennamalli Madhava R. R., Kampmann, T., Rao, N. S., Kobe, B. and Young, P. R. (2005). In silico screening and structure based drug design for the envelope protein of flaviviruses. 3rd Australian Virology Group Meeting, Phillip Island, Vic, 9-12 December, 2005.

KoRV, a retrovirus caught in the act of endogenization

Young, P. R., Tarlinton, R. E. and Meers, J. (2005). KoRV, a retrovirus caught in the act of endogenization. Australian Virology Group Meeting, Phillip Is, Vic., 9-12 Dec, 2005.

Koala Retrovirus (KoRV): Implications for koala management

Tarlinton, R. E., Meers, J. and Young, P. R. (2005). Koala Retrovirus (KoRV): Implications for koala management. 2005 Conference of The Australian Association of Veterinary Conservation Biologists, Gold Coast, Qld, 18-19 May 2005. Australia: Australian Veterinary Association.

Koala retrovirus (KoRV) may be the underlying cause of the high incidence of chlamydial disease in koalas

Simmons, Greg, Markey, B., Tarlinton, R., Hanger, J., Timms, P., Meers, J. and Young, P. (2005). Koala retrovirus (KoRV) may be the underlying cause of the high incidence of chlamydial disease in koalas. 3rd Australasian Virology Group Scientific Meeting, Cowes, Phillip Island, VIC, Australia, 9-12 December 2005.

Koala retrovirus (KoRV) may be the underlying cause of the high incidence of chlamydial disease in koalas

Simmons, G., Markey, B., Tarlinton, R. E., Hanger, J., Timms, P., Meers, J. and Young, P. R. (2005). Koala retrovirus (KoRV) may be the underlying cause of the high incidence of chlamydial disease in koalas. Showcasing Faculty research through our postgraduates, Gatton, Queensland, 8 December 2005. Gatton, Queensland: NRAVS Faculty.

Koala retrovirus (KoRV): Endogenization in action?

Young, P. R., Tarlinton, R. E., Meers, J., Hanger, J. and McKee, J. J. (2005). Koala retrovirus (KoRV): Endogenization in action?. International Congress of Virology, San Francisco, 23-27 July, 2005.

Koala retrovirus (KoRV): The link to disease and its place in koala ecology

Tarlinton, R. E., Simmons, G. S., Meers, J. and Young, P. R. (2005). Koala retrovirus (KoRV): The link to disease and its place in koala ecology. Wildlife Disease International Conference, Cairns, Qld, 26 June - 1 July, 2005.

Koalas at risk: From retroviruses to chlamydia

Tarlinton, R. E., Simmons, G. S., Phillips, C., Hanger, J., Markey, B, Timms, P., Meers, J. and Young, P. R. (2005). Koalas at risk: From retroviruses to chlamydia. Australian Society for Microbiology Annual Conference, Canberra, 25-29 Sept, 2005.

Molecular characterization of the dengue virus non-structural protein 1 membrane association

Panetta, A. K., Brown, L., Bletchly, C. and Young, P. R. (2005). Molecular characterization of the dengue virus non-structural protein 1 membrane association. 3rd Australian Virology Group Meeting, Phillip Island, Vic., 9-12 December, 2005.

Site-directed mutagenesis of the RSV F protein reveals key residues involved in membrane fusion

Desai, V. and Young, P. R. (2005). Site-directed mutagenesis of the RSV F protein reveals key residues involved in membrane fusion. 3rd Australian Virology Group Meeting, Phillip Island, Vic., 9-12 Dec, 2005.

Koala retrovirus (KORV): Endogenisation in action

Tarlinton, R. E., Meers, J., Hanger, J., McKee, Joseph and Young, P. R. (2004). Koala retrovirus (KORV): Endogenisation in action. 16th International Workshop on Retroviral Pathogenesis, Montreal, Canada, 27 - 31 October 2004. Canada:

Detection of dengue virus NS1 provides early diagnosis and is a prognostic marker of disease progression

Young, P. R., Libraty, D.H., Pickering, D., Endy, T.P., Kalayanarooj, S., Green, S., Vaughn, D. W., Nisalak, A., Ennis, F. A. and Rothman, A. (2003). Detection of dengue virus NS1 provides early diagnosis and is a prognostic marker of disease progression. 6th Asia Pacific Congress on Medical Virology, Kuala Lumpur, Malaysia, 7-10 December, 2003. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jcv.2003.09.010

Determination of the disulfide bond arrangement of Dengue virus NS1 by staple isotope labeling and mass spectrometry

Wallis, T. P., Huang, C., Nimkar, S., Young, P. R. and Gorman, J. (2003). Determination of the disulfide bond arrangement of Dengue virus NS1 by staple isotope labeling and mass spectrometry. ComBio 2003, Melbourne, 28 Sept - 2 Oct, 2003.

Dissecting dengue prM and E mediated fusion: SFV based expression

Young, P. R. and Robinson, J. (2003). Dissecting dengue prM and E mediated fusion: SFV based expression. Dengue Virus: Molecular Basis of Cell Entry & Pathogenesis, Vienna, 24-29 June, 2003.

Molecular epidemiology of RSV in Australia: evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages

Young, P. R. and Meteyard, J. (2003). Molecular epidemiology of RSV in Australia: evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages. 12th International Conference on Negative Strand Viruses, Pisa, Italy, 14-19 June, 2003.

Respiratory syncytial virus: targeted ribozymes at an antiviral approach to control

Young, P. R. (2003). Respiratory syncytial virus: targeted ribozymes at an antiviral approach to control. Virology Research Theme Workshop, Christchurch, 21 March, 2003.

The role of antigenic variation in repeat infections with respiratory syncytial virus - implications for vaccine strategies

Young, P. R. (2003). The role of antigenic variation in repeat infections with respiratory syncytial virus - implications for vaccine strategies. Virology Research Theme Workshop, Christchurch, N.Z., 21 March, 2003.

Even viruses do it - but why?

Young, P. R. and Jacobs, M. (2002). Even viruses do it - but why?. The Cell Biology and Function of GPIs Conference, Port Douglas, Qld, 12-14 July, 2002.

Molecular epidemiology of Australian bat lyssavirus

Guyatt, K. J., Twin, J., Smith, G., Smith, I., Mackenzie, J. S. and Young, P. R. (2002). Molecular epidemiology of Australian bat lyssavirus. The World of Microbes, XIIth Int Congress of Virology, Paris, France, 25 July - 1 August, 2002.

Molecular epidemiology of RSV in Australia

Young, P. R. and Meteyard, J. (2002). Molecular epidemiology of RSV in Australia. Australian Society for Microbiology Meeting, Melbourne, Vic., 29 Sept - 3 Oct, 2002.

Molecular epidemiology of RSV in Australia: Evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages

Young, P. R. and Meteyard, J. (2002). Molecular epidemiology of RSV in Australia: Evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages. International Congress of Virology, Paris, 27 July - 1 August.

A molecular epidemiological study of Australian bat lyssavirus

Guyatt, K. J., Twin, J., Smith, G., Smith, I., Mackenzie, J. S. and Young, P. (2001). A molecular epidemiological study of Australian bat lyssavirus. 1st Australian Virology Group Meeting, Fraser Island, December, 2001.

A role for GPI-anchored NS1 in dengue 2 virus infection of HeLa cells

Lichanska, A. M., Clarke, D. and Young, P. R. (2001). A role for GPI-anchored NS1 in dengue 2 virus infection of HeLa cells. 1st Australian Virology Group Meeting, Fraser Island, Qld, 5-9 December, 2001.

Activation and apoptosis in a murine macrophage cell line following dengue virus infection

Bhatia, K. and Young, P. R. (2001). Activation and apoptosis in a murine macrophage cell line following dengue virus infection. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.

Construction and characterization of the dengue 2 virus NS3 protease and its mutants

Fang, N., Arakaki, T., Fairlie, D., Martin, J. L. and Young, P. R. (2001). Construction and characterization of the dengue 2 virus NS3 protease and its mutants. 1st Australian Virology Group Meeting, Fraser Island, Qld, 5-9 December, 2001.

Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides

Pickering, D., Hume, D. A. and Young, P. R. (2001). Enhanced protection of mice from challenge with dengue virus following immunization with recombinant NS1 and CpG oligonucleotides. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.

In vitro catalytic activity of recombinant forms of the dengue virus NS3 protease

Young, P. R., Fang, N., Leung, D., Arakaki, T., Stoermer, M. J., Fairlie, D. and Martin, J. L. (2001). In vitro catalytic activity of recombinant forms of the dengue virus NS3 protease. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.

Molecular epidemiology of RSV in Australia: Evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages

Young, P. R. and Meteyard, J. (2001). Molecular epidemiology of RSV in Australia: Evidence for incomplete cross-protection by subtype strains phylogenetically mapped into different lineages. International Meeting on RSV - after 45 years, Segovia, Spain, 30 Sept - 3 Oct, 2001.

SFV based expression of dengue virus prM and E in insect cells has identified domains and key residues responsible for virus mediated fusion

Robinson, J. and Young, P. R. (2001). SFV based expression of dengue virus prM and E in insect cells has identified domains and key residues responsible for virus mediated fusion. 6th International Symposium on Positive Strand Viruses, Paris, France, 28 May - 2 June, 2001.

The phylogeny of Edge Hill virus

Macdonald, J., Broom, A. K., Doggett, S., Mackenzie, J. S., Phillips, D. A., Poidinger, M., Russell, R.C., Young, P. R. and Hall, R. A. (2001). The phylogeny of Edge Hill virus. 4th Mosquito Control Association of Australia Symposium and 8th Arbovirus Research in Australia Conference, South Stradbroke Island, 3-7 July, 2000. Brisbane: QUT.

The role of antiviral activity of ribozymes targeting respiratory syncytial virus mRNA

Meyer, M. N. and Young, P. R. (2001). The role of antiviral activity of ribozymes targeting respiratory syncytial virus mRNA. 1st Australian Virology Group Meeting, Fraser Island, Qld, 5-9 December, 2001.

Expression and characterization of a catalytically active form of the Dengue virus NS3 protease

Young, P. R., Fang, N., Leung, D., Arakaki, T., Fairlie, D. and Martin, J. L. (2000). Expression and characterization of a catalytically active form of the Dengue virus NS3 protease. 1st Int Conf on Dengue and Dengue Haemorrhagic Fever, Chiang Mai, Thailand, 20-24 Nov, 2000.

Comparison between recombinant baculovirus derived antigen and DNA vaccine vectors in conferring protective immunity against dengue in mice

Pickering, D. and Young, P. R. (1999). Comparison between recombinant baculovirus derived antigen and DNA vaccine vectors in conferring protective immunity against dengue in mice. XIth International Congress of Virology, Sydney, 9-13 August 1999. Sydney: International Union of Microbiological Societies.

DNA immunization with vectors expressing prM/E and NS1 of dengue virus confer protective immunity in mice

Young, P. R. and Pickering, D. (1999). DNA immunization with vectors expressing prM/E and NS1 of dengue virus confer protective immunity in mice. Cold Spring Harbor Laboratory, New York, 2-5 December 1999. New York, USA: Cold Spring Harbor Laboratory.

Genetic analysis of Australian bovine viral diarrhoea viruses and bovine herpesviruses

Mahony, T., McCarthy, F., Gravel, J., Clark, K. L., Wilks, C., Mackenzie, J. S. and Young, P. (1999). Genetic analysis of Australian bovine viral diarrhoea viruses and bovine herpesviruses. 11th International Congress of Virology, Sydney, 9-13 August 1999. Aust.: Int. Union of Microbiological Societies.

Homology model of the dengue 2 virus NS3 protease: Interactions with NS2B co-factor

White, H., Young, P. R., Brinkworth, R. I., Fairlie, D. and Leung, D. D. (1999). Homology model of the dengue 2 virus NS3 protease: Interactions with NS2B co-factor. XIth International Congress of Virology, Sydney, 9-13 August 1999. Sydney: International Union of Microbiological Societies.

Induction of proinflammatory cytokines by dengue virus in murine and human macrophages

Bhatia, K., White, H. and Young, P. R. (1999). Induction of proinflammatory cytokines by dengue virus in murine and human macrophages. XIth International Congress of Virology, Sydney, 9-13 August 1999. Sydney: International Union of Microbiological Societies.

Interaction between prM and proteins of dengue virus and their role in fusion

Robinson, J. and Young, P. R. (1999). Interaction between prM and proteins of dengue virus and their role in fusion. XIth International Congress of Virology, Sydney, 9-13 August 1999. Sydney: International Union of Microbiological Societies.

Up-regulation of P73 in hepatocellular carcinoma

Herath, N. I., Kew, M. C., Whitehall, V. L., Young, J. P., Powell, L. W., Leggett, B. A. and Macdonald, G. A. (1999). Up-regulation of P73 in hepatocellular carcinoma. Entering a New Era, Wyndham Anatole Hotel, Dallas, Texas, 5-9 November, 1999. Hoboken, NJ: Wiley Interscience.

Properties of Pichinde, An Arenavirus

Young, P, Chanas, A, Howard, C, Mann, G and Ellis, D (1980). Properties of Pichinde, An Arenavirus. LONDON: ROYAL SOC TROPICAL MEDICINE.