High resolution single particle analysis of biological macromolecules (2004–2006)

One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolution electron microscope images of individual randomly oriented molecules. The importance of this project is highlighted by the fact over
Grant type:
ARC Discovery Projects
Funded by:
Australian Research Council