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A functional interaction between domains of the flavivirus NS5 protein presents a new target for antiviral therapy (2010–2012)

Abstract:
Mosquito-transmitted flaviviruses such as gengue, yellow fever, Japanese encephalitis and West Nile infect hundreds of millions of people and cause debilitating and fatal diseases. Developing anti-viral treatments against these diseases is a high priority. Our strategy is to develop small molecules that can bind to specific sites on viral proteins and prevent the virus from replicating and causing disease.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Alexander Khromykh

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience

  • Professor Paul Young

    Professor, Research Development
    Office of the Deputy Vice-Chancellor (Research and Innovation)
    Professor, Research Development
    Office of the Deputy Vice-Chancellor (Research and Innovation)
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
National Health and Medical Research Council