Dr Arutha Kulasinghe

Senior Research Fellow

Frazer Institute
Faculty of Medicine

Overview

Dr Arutha Kulasinghe is a Senior Research Fellow and leads the Clinical-oMx Lab at the University of Queensland. Dr Kulasinghe has pioneered spatial transcriptomics using digital spatial profiling approaches in the Asia-Pacific region, contributing to world-first studies for lung cancer, head and neck cancer, and COVID-19. His research aims to understand the underlying pathobiology by using an integrative multi-omics approach.

Research Interests

  • Immuno-oncology
    Applications in lung, skin, and head and neck cancers.
  • Spatial transcriptomics
    Applications across solid tumours and COVID-19
  • Liquid Biopsies
    Applications in lung cancer, and head and neck cancer

Qualifications

  • Doctor of Philosophy, Queensland University of Technology

Publications

  • Ravichandran, Akhilandeshwari, Monkman, James, Mehdi, Ahmed M., Blick, Tony, Snell, Cameron, Kulasinghe, Arutha and Bray, Laura J. (2024). The in situ transcriptomic landscape of breast tumour-associated and normal adjacent endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870 (2) 166985, 166985. doi: 10.1016/j.bbadis.2023.166985

  • Davoudi, Fatemeh, Moradi, Afshin, Sadeghirad, Habib and Kulasinghe, Arutha (2024). Tissue biomarkers of immune checkpoint inhibitor therapy. Immunology & Cell Biology. doi: 10.1111/imcb.12723

  • Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021

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Grants

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Featured Publications

  • Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021

Book Chapter

  • Radfar, Payar, Es, Hamidreza Aboulkheyr, Kulasinghe, Arutha, Thiery, Jean Paul and Warkiani, Majid Ebrahimi (2023). Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention. Circulating Tumor Cells. (pp. 359-385) Cham: Springer International Publishing. doi: 10.1007/978-3-031-22903-9_14

  • Müller Bark, Juliana, Kulasinghe, Arutha, Amenábar, José Miguel and Punyadeera, Chamindie (2021). Exosomes in cancer. Advances in Clinical Chemistry. (pp. 1-40) edited by Gregory S Makowski. San Diego, CA, United States: Academic Press. doi: 10.1016/bs.acc.2020.06.006

  • Azadi, Shohreh, Aboulkheyr Es, Hamidreza, Kulasinghe, Arutha, Bordhan, Pritam and Ebrahimi Warkiani, Majid (2020). Application of microfluidic technology in cancer research and therapy. Advances in Clinical Chemistry. (pp. 193-235) edited by Gregory S. Makowski. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.acc.2020.02.012

  • Kulasinghe, Arutha, Warkiani, Majid Ebrahimi and Punyadeera, Chamindie (2019). The isolation and characterization of circulating tumor cells from head and neck cancer patient blood samples using spiral microfluidic technology. Methods in Molecular Biology. (pp. 129-136) New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9769-5_8

  • Kulasinghe, Arutha, Schmidt, Henri and Punyadeera, Chamindie (2016). Circulating tumor cells: isolation, expansion, characterization and translation to clinic. Circulating tumor cells (CTCs): detection methods, health impact and emerging clinical challenges. (pp. 1-18) edited by Paresh Chandra Ray. New York, NY United States: Nova Science Publishers, Inc..

  • Kulasinghe, Arutha, Lim, Yenkai, Perry, Chris F. L. and Punyadeera, Chamindie (2015). Current trends and management in head and neck cancers. Head and neck cancer: epidemiology, management, and treatment outcomes. (pp. 41-74) edited by Madison R. Hall. New York, NY United States: Nova Science Publishers.

  • Zhang, Xi, Kulasinghe, Arutha, Karim, Rafid Shahriyar and Punyadeera, Chamindie (2015). Saliva diagnostics for oral diseases. Advances in salivary diagnostics. (pp. 131-156) edited by Charles F. Streckfus. Berlin, Germany: Springer Berlin Heidelberg. doi: 10.1007/978-3-662-45399-5_7

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision