Associate Professor Fernando Guimaraes

Principal Research Fellow

Frazer Institute
Faculty of Medicine

Affiliate Senior Research Fellow

School of Biomedical Sciences
Faculty of Medicine

Overview

In 2012, I achieved a significant milestone by becoming the first student to complete a doctoral degree from the International PhD Program at Institute Pasteur, Paris/France. This accomplishment not only set the trajectory of my academic pursuits but also underscored my dedication and passion for research in immunology. My postdoctoral journey began at QIMR in 2013 and concluded at WEHI in 2019, further refining my expertise in cancer immunoediting and immunotherapy. My dedication to my field has been recognized through numerous peer-reviwed grants as sole-CI or CIA/Principal Investigator, including a NHMRC ECF Peter Doherty Fellowship, an NHMRC Project Grant, an US DoD, a MRFF among others. Since 2009, I've amassed an impressive portfolio of 90 publications in renowned journals like Blood, Cell Death Dis, JEM, PNAS, Nat Comms, and Nat Immunol with an H-index = 38. My body of work and contributions have been acknowledged with awards such as the 2019 Researcher of the Year by CCA, 2020 QLD Young Tall Poppy Science Award, 2020 UQDI Rising Star Award, the 2022 Frazer Institute's Mentor of the Year Award among others. Recognized as an international leader in my field, I've been instrumental in identifying novel regulators of our immune functions, and developing Natural Killer (NK) cell-based immunotherapies. At present, I am a Group Leader / Principal Research Fellow & Associate Professor with the University of Queensland's Frazer Institute. Here, I lead a high-performing research team with a keen focus on developing and innovating immunotherapy approaches for a spectrum of diseases.

Research Interests

  • NK cells
    Overview: Natural Killer (NK) cells are a crucial component of the innate immune system, recognized for their ability to target and destroy cancerous or infected cells without prior sensitization. Their unique capability to distinguish between healthy and abnormal cells makes them pivotal in immunological defenses and cancer immunosurveillance. Current research: My current research focuses on unraveling the complex interactions of NK cells within various disease environments. We are investigating how NK cells respond to different cancer types, particularly in the context of hard-to-cure solid cancers (e.g. pediatric sarcomas). Our recent findings suggest novel pathways through which NK cells can be modulated to enhance their cytotoxicity against tumor cells. We are also exploring the impact of the tumor microenvironment on NK cell function, hypothesizing that certain microenvironmental factors might inhibit their activity and how this can be counteracted. Future directions: Looking forward, our goal is to develop strategies to boost NK cell efficacy in cancer therapy. This includes genetic engineering of NK cells to enhance their tumor-targeting capabilities and the identification of new biomarkers for predicting patient response to NK cell-based therapies. Our ultimate aim is to leverage NK cells' natural abilities to create more effective and less toxic cancer treatments.
  • Systems immunology and checkpoint discovery
    Explanation of systems immunology: Systems immunology integrates computational and experimental approaches to understand the immune system's complexity. By analyzing vast datasets, we can decipher the intricate network of cellular interactions and molecular pathways that govern immune responses in diseases ranging from viral infections to cancer. Immunomodulation and disease environments: Our research in systems immunology focuses on understanding how immunomodulation varies across different disease states. We are particularly interested in how immune checkpoints, which are regulatory pathways crucial to maintaining self-tolerance and preventing autoimmunity, can be exploited or inhibited in disease contexts. For instance, we are exploring how tumor cells evade immune surveillance by manipulating these checkpoints. Impact of Research: This research holds significant promise for unveiling new therapeutic targets and developing personalized medicine approaches. Understanding these complex immune interactions can lead to the discovery of novel treatments that precisely modulate the immune system to combat various diseases effectively.
  • Development of tailored immunotherapies
    Introduction to tailored immunotherapies: Tailored immunotherapies represent a revolutionary approach in medicine, offering treatments that are specifically designed to match an individual's unique immune profile. This personalized approach is particularly crucial in treating hard-to-cure diseases, where standard therapies often fall short. From antibody discovery to development: My team is actively engaged in the discovery and development of novel antibodies. We focus on identifying antibodies that can specifically target and modulate key components of the immune system. The journey from discovery to development involves extensive research to ensure efficacy and safety, with a keen focus on creating therapies that can be personalized for individual patients. Cellular immunotherapies: Our work in cellular immunotherapies involves engineering immune cells, such as T-cells and NK cells, to better recognize and attack cancer cells. We are exploring various techniques, including CAR-NK cell therapy, to enhance these cells' ability to fight cancer more effectively. Real-world applications: The potential real-world applications of our research are vast. For example, our work in antibody development could lead to new treatments for autoimmune diseases or cancer. Similarly, our advancements in cellular therapies could revolutionize the way we treat various forms of cancer, offering hope to patients with previously untreatable conditions.

Qualifications

  • Doctor of Philosophy

Publications

  • Alim, Louisa F, Keane, Colm and Souza-Fonseca-Guimaraes, Fernando (2024). Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment. Current Opinion in Immunology, 86 102409, 102409. doi: 10.1016/j.coi.2023.102409

  • Goh, Wilford, Sudholz, Harrison, Foroutan, Momeneh, Scheer, Sebastian, Pfefferle, Aline, Delconte, Rebecca B., Meng, Xiangpeng, Shen, Zihan, Hennessey, Robert, Kong, Isabella Y., Schuster, Iona S., Andoniou, Christopher E., Davis, Melissa J., Hediyeh-Zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, Parish, Ian A., Beavis, Paul, Thiele, Daniel, Chopin, Michael, Degli-Esposti, Mariapia A., Cursons, Joe, Kallies, Axel, Rautela, Jai, Nutt, Stephen L. and Huntington, Nicholas D. (2024). IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature Immunology, 25 (2), 240-255. doi: 10.1038/s41590-023-01718-4

  • Tu, Cui, Kulasinghe, Arutha, Barbour, Andrew and Souza-Fonseca-Guimaraes, Fernando (2024). Leveraging spatial omics for the development of precision sarcoma treatments. Trends in Pharmacological Sciences, 45 (2), 134-144. doi: 10.1016/j.tips.2023.12.006

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Grants

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Supervision

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Available Projects

  • Background: Despite advances in treatment and earlier detection, cancer is still a main cause of cancer death worldwide. Natural killer (NK) cells are circulating innate lymphocytes that naturally protect against tumor spread (metastasis), and recently showed by our group as dysfunctional in the tumour microenvironment (TME) established by cancers at distant organs for future metastatic spread. Yet, despite knowing that NK cells do control cancer metastasis, our knowledge of how cancer cells evade NK cell control is still very poor. This project aims to examine several immune suppressive pathways that cancers likely manipulate to avoid NK cells and spread. These include factors the transforming growth factor (TGF)-β superfamily that are elevated in the tumor environment. These molecules have great potential to suppress the normally high killing and anti-metastatic activity mediated by NK cells, but to date we still need to elucidate how relatively important each pathway might be.

    Proposed research program: The intrinsic NK cell function under suppressive factors stimulation will be assessed with NK cells purified from mouse spleen (wild type) by cell sorter, and in vitro challenge with activating cytokines and suppressive factors. Aim-1: Which suppressive factor is a major inhibitor of NK cell killing activity? This aim will be screened by killing activity of NK cells versus target tumour cells in co-culture systems. Aim-2: Which suppressive factor is a major inhibitor of NK cell cytokine secretion? This aim will assess NK cell cytokine production by intracellular cytokine (e.g. IFN-gamma) staining (flow cytometry) and secreted IFN-gamma, among others, from culture supernatants (ELISA); Aim-3: What is the cellular signalling status under suppressive conditions? The identification of altered cellular signalling will be screened by intracellular staining of phosphorylated signalling molecules (phosphor(p)-AKT, p-ERK1/2, p-p38, p-phospholipase C-gamma2, p-phosphotyrosine, p-SMAD2,3, p-STAT4, p-STAT5 and p-ZAP70 (PhosphoFlow).

    These experimental tools will determine which is the most important suppressive pathway in inhibiting NK cell functions. Information we obtain from this work will allow us to design rationale approaches to increase NK cell function in personalised immunotherapy approaches.

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Publications

Journal Article

  • Alim, Louisa F, Keane, Colm and Souza-Fonseca-Guimaraes, Fernando (2024). Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment. Current Opinion in Immunology, 86 102409, 102409. doi: 10.1016/j.coi.2023.102409

  • Goh, Wilford, Sudholz, Harrison, Foroutan, Momeneh, Scheer, Sebastian, Pfefferle, Aline, Delconte, Rebecca B., Meng, Xiangpeng, Shen, Zihan, Hennessey, Robert, Kong, Isabella Y., Schuster, Iona S., Andoniou, Christopher E., Davis, Melissa J., Hediyeh-Zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, Parish, Ian A., Beavis, Paul, Thiele, Daniel, Chopin, Michael, Degli-Esposti, Mariapia A., Cursons, Joe, Kallies, Axel, Rautela, Jai, Nutt, Stephen L. and Huntington, Nicholas D. (2024). IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development. Nature Immunology, 25 (2), 240-255. doi: 10.1038/s41590-023-01718-4

  • Tu, Cui, Kulasinghe, Arutha, Barbour, Andrew and Souza-Fonseca-Guimaraes, Fernando (2024). Leveraging spatial omics for the development of precision sarcoma treatments. Trends in Pharmacological Sciences, 45 (2), 134-144. doi: 10.1016/j.tips.2023.12.006

  • Stylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E, Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T, Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical & Translational Immunology, 13 (2) e1488, e1488. doi: 10.1002/cti2.1488

  • Shafiee, Abbas, Sun, Jane, Ahmed, Imaan A., Phua, Felicia, Rossi, Gustavo R., Lin, Cheng‐Yu, Souza‐Fonseca‐Guimaraes, Fernando, Wolvetang, Ernst J., Brown, Jason and Khosrotehrani, Kiarash (2023). Development of physiologically relevant skin organoids from human induced pluripotent stem cells. Small e2304879, 1-14. doi: 10.1002/smll.202304879

  • Tan, Xiao, Grice, Laura F., Tran, Minh, Mulay, Onkar, Monkman, James, Blick, Tony, Vo, Tuan, Almeida, Ana Clara, da Silva Motta, Jarbas, Fernandes de Moura, Karen, Machado‐Souza, Cleber, Souza‐Fonseca‐Guimaraes, Paulo, Baena, Cristina Pellegrino, de Noronha, Lucia, Guimaraes, Fernanda Simoes Fortes, Luu, Hung N., Drennon, Tingsheng, Williams, Stephen, Stern, Jacob, Uytingco, Cedric, Pan, Liuliu, Nam, Andy, Cooper, Caroline, Short, Kirsty, Belz, Gabrielle T., Souza‐Fonseca‐Guimaraes, Fernando, Kulasinghe, Arutha and Nguyen, Quan (2023). A robust platform for integrative spatial multi‐omics analysis to map immune responses to SARS‐CoV‐2 infection in lung tissues. Immunology, 170 (3), 401-418. doi: 10.1111/imm.13679

  • Poursani, Ensieh M., Mercatelli, Daniele, Raninga, Prahlad, Bell, Jessica L., Saletta, Federica, Kohane, Felix V., Neumann, Daniel P., Zheng, Ye, Rouaen, Jourdin R. C., Jue, Toni Rose, Michniewicz, Filip T., Schadel, Piper, Kasiou, Erin, Tsoli, Maria, Cirillo, Giuseppe, Waters, Shafagh, Shai-Hee, Tyler, Cazzoli, Riccardo, Brettle, Merryn, Slapetova, Iveta, Kasherman, Maria, Whan, Renee, Souza-Fonseca-Guimaraes, Fernando, Vahdat, Linda, Ziegler, David, Lock, John G., Giorgi, Federico M., Khanna, KumKum and Vittorio, Orazio (2023). Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer. Cell and Bioscience, 13 (1) 132, 132. doi: 10.1186/s13578-023-01083-7

  • McCulloch, Timothy R., Rossi, Gustavo Rodrigues, Lam, Allie, Wong, Joshua, Kane, Lawrence P, Herold, Marco, Wells, Timothy and Souza-Fonseca-Guimaraes, Fernando (2023). Differential regulation of natural killer cells by tumor necrosis factor receptors 1 and 2. The Journal of Immunology, 210 (S1), 72.28-72.28. doi: 10.4049/jimmunol.210.supp.72.28

  • Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W. and Bywater, Megan J. (2023). Oncogenic drivers dictate immune control of acute myeloid leukemia. Nature Communications, 14 (1) 2155, 1-14. doi: 10.1038/s41467-023-37592-9

  • Wong, Joshua K.M., Dolcetti, Riccardo, Rhee, Handoo, Simpson, Fiona and Souza-Fonseca-Guimaraes, Fernando (2023). Weaponizing natural killer cells for solid cancer immunotherapy. Trends in Cancer, 9 (2), 111-121. doi: 10.1016/j.trecan.2022.10.009

  • Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin ... Tang, Benjamin (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13 1060438, 1-14. doi: 10.3389/fimmu.2022.1060438

  • Zhang, Shengbo, Rautela, Jai, Bediaga, Naiara G., Kolesnik, Tatiana B., You, Yue, Nie, Junli, Dagley, Laura F., Bedo, Justin, Wang, Hanqing, Sun, Li, Sutherland, Robyn, Surgenor, Elliot, Iannarella, Nadia, Allan, Rhys, Souza-Fonseca-Guimaraes, Fernando, Xie, Yi, Wang, Qike, Zhang, Yuxia, Xu, Yuekang, Nutt, Stephen L., Lew, Andrew M., Huntington, Nicholas D., Nicholson, Sandra E., Chopin, Michaël and Zhan, Yifan (2022). CIS controls the functional polarization of GM-CSF-derived macrophages. Cellular and Molecular Immunology, 20 (1), 65-79. doi: 10.1038/s41423-022-00957-z

  • Misset, Benoît, Philippart, François, Fitting, Catherine, Bedos, Jean-Pierre, Diehl, Jean-Luc, Hamzaoui, Olfa, Annane, Djillali, Journois, Didier, Parlato, Marianna, Moucadel, Virginie, Cavaillon, Jean-Marc, Coste, Joël, Jacqmin, Sébastien, Journois, Didier, Lagrange, Alix, Pinot de Ville-Chenon, Gabrielle, Aissaoui, Nadia, Diehl, Jean-Luc, Guerot, Emmanuel, Venot, Marion, Hamzaoui, Olfa, Prat, Dominique, Sztrymf, Benjamin, Annane, Djillali, Maxime, Virginie, Polito, Andrea, Bouhemad, Belaïd, Bruel, Cédric, Ethuin, Frédéric ... Souza-Fonseca-Guimaraes, Fernando (2022). Clustering ICU patients with sepsis based on the patterns of their circulating biomarkers: A secondary analysis of the CAPTAIN prospective multicenter cohort study. PLoS One, 17 (10) e0267517, 1-17. doi: 10.1371/journal.pone.0267517

  • Goncalves, Jenifer P., Deliwala, Vatsal J., Kolarich, Daniel, Souza-Fonseca-Guimaraes, Fernando and Wolfram, Joy (2022). The cancer cell-derived extracellular vesicle glycocode in immunoevasion. Trends in Immunology, 43 (11), 864-867. doi: 10.1016/j.it.2022.09.004

  • Kulasinghe, Arutha, Liu, Ning, Tan, Chin Wee, Monkman, James, Sinclair, Jane E., Bhuva, Dharmesh D., Godbolt, David, Pan, Liuliu, Nam, Andy, Sadeghirad, Habib, Sato, Kei, Bassi, Gianluigi Li, O'Byrne, Ken, Hartmann, Camila, Miggiolaro, Anna Flavia Ribeiro dos Santos, Marques, Gustavo Lenci, Moura, Lidia Zytynski, Richard, Derek, Adams, Mark, Noronha, Lucia de, Baena, Cristina Pellegrino, Suen, Jacky Y., Arora, Rakesh, Belz, Gabrielle T., Short, Kirsty R., Davis, Melissa J., Souza‐Fonseca Guimaraes, Fernando and Fraser, John F. (2022). Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage. Immunology, 168 (3), 403-419. doi: 10.1111/imm.13577

  • Raza, Aun, Rossi, Gustavo Rodrigues, Janjua, Taskeen Iqbal, Souza-Fonseca-Guimaraes, Fernando and Popat, Amirali (2022). Nanobiomaterials to modulate natural killer cell responses for effective cancer immunotherapy. Trends in Biotechnology, 41 (1), 77-92. doi: 10.1016/j.tibtech.2022.06.011

  • Souza-Fonseca Guimaraes, Fernando, Rossi, Gustavo R., Dagley, Laura F., Foroutan, Momeneh, McCulloch, Timothy R., Yousef, Jumana, Park, Hae-Young, Gunter, Jennifer H., Beavis, Paul A., Lin, Cheng-Yu, Hediyeh-zadeh, Soroor, Camilleri, Tania, Davis, Melissa J. and Huntington, Nicholas D. (2022). TGF-β and CIS inhibition overcomes NK cell suppression to restore anti-tumor immunity. Cancer Immunology Research, 10 (9), 1047-1054. doi: 10.1158/2326-6066.cir-21-1052

  • Chandra, Janin, Hansen, Morten, Labarriere, Nathalie, Marigo, Ilaria, Souza-Fonseca-Guimaraes, Fernando, Vujanovic, Lazar, Koguchi, Yoshinobu and Jacquelot, Nicolas (2022). Editorial: Cancer Immunotherapies: From Efficacy to Resistance Mechanisms. Frontiers in Immunology, 13 939789, 939789. doi: 10.3389/fimmu.2022.939789

  • McCulloch, Timothy R., Rossi, Gustavo R., Schreuder, Jaring, Belz, Gabrielle T., Wells, Timothy J. and Souza‐Fonseca‐Guimaraes, Fernando (2022). CIS and TGF ‐β regulatory pathways influence immunity to bacterial infection. Immunology, 167 (1), 54-63. doi: 10.1111/imm.13516

  • Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021

  • Mangiola, Stefano, McCoy, Patrick, Modrak, Martin, Souza-Fonseca-Guimaraes, Fernando, Blashki, Daniel, Stuchbery, Ryan, Keam, Simon P., Kerger, Michael, Chow, Ken, Nasa, Chayanica, Le Page, Melanie, Lister, Natalie, Monard, Simon, Peters, Justin, Dundee, Phil, Williams, Scott G., Costello, Anthony J., Neeson, Paul J., Pal, Bhupinder, Huntington, Nicholas D., Corcoran, Niall M., Papenfuss, Anthony T. and Hovens, Christopher M. (2021). Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression. BMC Cancer, 21 (1) 846, 846. doi: 10.1186/s12885-021-08529-6

  • Omer, Natacha, Nicholls, Wayne, Ruegg, Bronte, Souza-Fonseca-Guimaraes, Fernando and Rossi, Gustavo Rodrigues (2021). Enhancing natural killer cell targeting of pediatric sarcoma. Frontiers in Immunology, 12 791206, 791206. doi: 10.3389/fimmu.2021.791206

  • Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S. F., Clifton, Vicki L. and Kulasinghe, Arutha (2021). The effects of COVID-19 on the placenta during pregnancy. Frontiers in Immunology, 12 743022. doi: 10.3389/fimmu.2021.743022

  • Christo, Susan N., Evrard, Maximilien, Park, Simone L., Gandolfo, Luke C., Burn, Thomas N., Fonseca, Raissa, Newman, Dane M., Alexandre, Yannick O., Collins, Nicholas, Zamudio, Natasha M., Souza-Fonseca-Guimaraes, Fernando, Pellicci, Daniel G., Chisanga, David, Shi, Wei, Bartholin, Laurent, Belz, Gabrielle T., Huntington, Nicholas D., Lucas, Andrew, Lucas, Michaela, Mueller, Scott N., Heath, William R., Ginhoux, Florent, Speed, Terence P., Carbone, Francis R., Kallies, Axel and Mackay, Laura K. (2021). Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nature Immunology, 22 (9), 1140-1151. doi: 10.1038/s41590-021-01004-1

  • Jacquelot, Nicolas, Seillet, Cyril, Souza-Fonseca-Guimaraes, Fernando, Sacher, Adrian G, Belz, Gabrielle T and Ohashi, Pamela S (2021). Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: current knowledge and future perspectives. International Journal of Molecular Sciences, 22 (16) 9044, 1-32. doi: 10.3390/ijms22169044

  • Gabriel, Sarah S., Tsui, Carlson, Chisanga, David, Weber, Flora, Llano-León, Manuela, Gubser, Patrick M., Bartholin, Laurent, Souza-Fonseca-Guimaraes, Fernando, Huntington, Nicholas D., Shi, Wei, Utzschneider, Daniel T. and Kallies, Axel (2021). Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection. Immunity, 54 (8), 1698-1714.e5. doi: 10.1016/j.immuni.2021.06.007

  • Petley, Emma V., Koay, Hui-Fern, Henderson, Melissa A., Sek, Kevin, Todd, Kirsten L., Keam, Simon P., Lai, Junyun, House, Imran G., Li, Jasmine, Zethoven, Magnus, Chen, Amanda X. Y., Oliver, Amanda J., Michie, Jessica, Freeman, Andrew J., Giuffrida, Lauren, Chan, Jack D., Pizzolla, Angela, Mak, Jeffrey Y. W., McCulloch, Timothy R., Souza-Fonseca-Guimaraes, Fernando, Kearney, Conor J., Millen, Rosemary, Ramsay, Robert G., Huntington, Nicholas D., McCluskey, James, Oliaro, Jane, Fairlie, David P., Neeson, Paul J., Godfrey, Dale I. ... Darcy, Phillip K. (2021). MAIT cells regulate NK cell-mediated tumor immunity. Nature Communications, 12 (1) 4746, 1-15. doi: 10.1038/s41467-021-25009-4

  • McCulloch, Timothy R., Wells, Timothy J. and Souza-Fonseca-Guimaraes, Fernando (2021). Towards efficient immunotherapy for bacterial infection. Trends in Microbiology, 30 (2), 158-169. doi: 10.1016/j.tim.2021.05.005

  • Souza-Fonseca-Guimaraes, Fernando (2021). New horizons for natural killer cell research in cancer, infection and inflammation. Clinical & Translational Immunology, 10 (4) e1275, e1275. doi: 10.1002/cti2.1275

  • Huang, Qiutong, Jacquelot, Nicolas, Preaudet, Adele, Hediyeh-zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, McKenzie, Andrew N. J., Hansbro, Philip M., Davis, Melissa J., Mielke, Lisa A., Putoczki, Tracy L. and Belz, Gabrielle T. (2021). Type 2 innate lymphoid cells protect against colorectal cancer progression and predict improved patient survival. Cancers, 13 (3) 559, 559-16. doi: 10.3390/cancers13030559

  • Jacquelot, Nicolas, Seillet, Cyril, Wang, Minyu, Pizzolla, Angela, Liao, Yang, Hediyeh-zadeh, Soroor, Grisaru-Tal, Sharon, Louis, Cynthia, Huang, Qiutong, Schreuder, Jaring, Souza-Fonseca-Guimaraes, Fernando, de Graaf, Carolyn A., Thia, Kevin, Macdonald, Sean, Camilleri, Mary, Luong, Kylie, Zhang, Shengbo, Chopin, Michael, Molden-Hauer, Tristan, Nutt, Stephen L., Umansky, Viktor, Ciric, Bogoljub, Groom, Joanna R., Foster, Paul S., Hansbro, Philip M., McKenzie, Andrew N. J., Gray, Daniel H. D., Behren, Andreas, Cebon, Jonathan ... Belz, Gabrielle T. (2021). Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 22 (7), 851-864. doi: 10.1038/s41590-021-00943-z

  • Yang, Yuyan, Day, Jessica, Souza-Fonseca Guimaraes, Fernando, Wicks, Ian P. and Louis, Cynthia (2021). Natural killer cells in inflammatory autoimmune diseases. Clinical & Translational Immunology, 10 (2) e1250, e1250. doi: 10.1002/cti2.1250

  • Lin, Cheng-Yu, Gobius, Ilan and Souza-Fonseca-Guimaraes, Fernando (2020). Natural killer cell engineering – a new hope for cancer immunotherapy. Seminars in Hematology, 57 (4), 194-200. doi: 10.1053/j.seminhematol.2020.10.002

  • Rossi, Gustavo R., Gonçalves, Jenifer P., McCulloch, Timothy, Delconte, Rebecca B., Hennessy, Robert J., Huntington, Nicholas D., Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). The antitumor effect of heparin is not mediated by direct NK cell activation. Journal of Clinical Medicine, 9 (8) 2666, 2666-11. doi: 10.3390/jcm9082666

  • Best, Sarah A., Hess, Jonas B., Souza-Fonseca-Guimaraes, Fernando, Cursons, Joseph, Kersbergen, Ariena, Dong, Xueyi, Rautela, Jai, Hyslop, Stephanie R., Ritchie, Matthew E., Davis, Melissa J., Leong, Tracy L., Irving, Louis, Steinfort, Daniel, Huntington, Nicholas D. and Sutherland, Kate D. (2020). Harnessing natural killer immunity in metastatic SCLC. Journal of Thoracic Oncology, 15 (9), 1507-1521. doi: 10.1016/j.jtho.2020.05.008

  • Louis, Cynthia, Souza-Fonseca-Guimaraes, Fernando, Yang, Yuyan, D'Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J., Babon, Jeffrey J., Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S., Huntington, Nicholas D. and Wicks, Ian P. (2020). Erratum:NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (Journal of Experimental Medicine (2020) 217:5 DOI: 10.1084/jem.20191421). Journal of Experimental Medicine, 217 (5) e2019142103192020c. doi: 10.1084/jem.2019142103192020c

  • Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

  • Louis, Cynthia, Souza-Fonseca-Guimaraes, Fernando, Yang, Yuyan, D’Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J., Babon, Jeffrey J., Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S., Huntington, Nicholas D. and Wicks, Ian P. (2020). NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. Journal of Experimental Medicine, 217 (5) e20191421. doi: 10.1084/jem.20191421

  • Delconte, Rebecca B., Guittard, Geoffrey, Goh, Wilford, Hediyeh-Zadeh, Soroor, Hennessy, Robert J., Rautela, Jai, Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Nunes, Jacques A. and Huntington, Nicholas D. (2020). NK cell priming from endogenous homeostatic signals is modulated by CIS. Frontiers in Immunology, 11 75, 75. doi: 10.3389/fimmu.2020.00075

  • Rossi, Gustavo Rodrigues, Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). Tumor microenvironment-associated extracellular matrix components regulate NK cell function. Frontiers in Immunology, 11 73, 73. doi: 10.3389/fimmu.2020.00073

  • Rautela, Jai, Dagley, Laura F., Kratina, Tobias, Anthony, Angaleena, Goh, Wilford, Surgenor, Elliot, Delconte, Rebecca B., Webb, Andrew I., Elwood, Ngaire, Groom, Joanna R., Souza-Fonseca-Guimaraes, Fernando, Corcoran, Lynn and Huntington, Nicholas D. (2019). Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells. Molecular Immunology, 115, 56-63. doi: 10.1016/j.molimm.2018.08.017

  • Rautela, Jai, Dagley, Laura F., de Oliveira, Carolina C., Schuster, Iona S., Hediyeh-Zadeh, Soroor, Delconte, Rebecca B., Cursons, Joseph, Hennessy, Robert, Hutchinson, Dana S., Harrison, Craig, Kita, Badia, Vivier, Eric, Webb, Andrew I., Degli-Esposti, Mariapia A., Davis, Melissa J., Huntington, Nicholas D. and Souza-Fonseca-Guimaraes, Fernando (2019). Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. Science Signaling, 12 (596) aat7527, eaat7527. doi: 10.1126/scisignal.aat7527

  • Cursons, Joseph, Souza-Fonseca-Guimaraes, Fernando, Foroutan, Momeneh, Anderson, Ashley, Hollande, Frédéric, Hediyeh-Zadeh, Soroor, Behren, Andreas, Huntington, Nicholas D. and Davis, Melissa J. (2019). A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients. Cancer Immunology Research, 7 (7), 1162-1174. doi: 10.1158/2326-6066.cir-18-0500

  • Healy, Lachlan P., Rossi, Gustavo R., Rautela, Jai, Slade, Charlotte A., Huntington, Nicholas D., Winship, Ingrid M. and Souza-Fonseca-Guimaraes, Fernando (2019). Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF-β. Frontiers in Immunology, 10 (MAY) 904. doi: 10.3389/fimmu.2019.00904

  • Lelliott, Emily J., Cullinane, Carleen, Martin, Claire A., Walker, Rachael, Ramsbottom, Kelly M., Souza-Fonseca-Guimaraes, Fernando, Abuhammad, Shatha, Michie, Jessica, Kirby, Laura, Young, Richard J., Slater, Alison, Lau, Peter, Meeth, Katrina, Oliaro, Jane, Haynes, Nicole, McArthur, Grant A. and Sheppard, Karen E. (2019). A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy. Scientific Reports, 9 (1) 1225. doi: 10.1038/s41598-018-37883-y

  • Souza-Fonseca-Guimaraes, Fernando, Cursons, Joseph and Huntington, Nicholas D. (2019). The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy. Trends in Immunology, 40 (2), 142-158. doi: 10.1016/j.it.2018.12.003

  • Briassoulis, George, Briassoulis, Panagiotis, Miliaraki, Marianna, Ilia, Stavroula, Parlato, Marianna, Philippart, François, Rouquette, Alexandra, Moucadel, Virginie, Cavaillon, Jean-Marc, Misset, Benoît, Combined Approach for The eArly diagnosis of INfection in sepsis (CAPTAIN) study group and Guimaraes, Fernando (2019). Biomarker cruises in sepsis: who is the CAPTAIN? Discussion on “Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study”. Intensive Care Medicine, 45 (1), 132-133. doi: 10.1007/s00134-018-5451-y

  • Sheikh, Amania A., Cooper, Lucy, Feng, Meiqi, Souza-Fonseca-Guimaraes, Fernando, Lafouresse, Fanny, Duckworth, Brigette C., Huntington, Nicholas D., Moon, James J., Pellegrini, Marc, Nutt, Stephen L., Belz, Gabrielle T., Good-Jacobson, Kim L. and Groom, Joanna R. (2019). Context-dependent role for T-bet in T follicular helper differentiation and germinal center function following viral infection. Cell Reports, 28 (7), 1758-1772.e4. doi: 10.1016/j.celrep.2019.07.034

  • Tye, Hazel, Yu, Chien-Hsiung, Simms, Lisa A., de Zoete, Marcel R., Kim, Man Lyang, Zakrzewski, Martha, Penington, Jocelyn S., Harapas, Cassandra R., Souza-Fonseca-Guimaraes, Fernando, Wockner, Leesa F., Preaudet, Adele, Mielke, Lisa A., Wilcox, Stephen A., Ogura, Yasunori, Corr, Sinead C., Kanojia, Komal, Kouremenos, Konstantinos A., De Souza, David P., McConville, Malcolm J., Flavell, Richard A., Gerlic, Motti, Kile, Benjamin T., Papenfuss, Anthony T., Putoczki, Tracy L., Radford-Smith, Graham L. and Masters, Seth L. (2018). NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications, 9 (1) 3728, 3728. doi: 10.1038/s41467-018-06125-0

  • Jiao, Yuhao, Davis, Joanne E., Rautela, Jai, Carrington, Emma M., Ludford-Menting, Mandy J., Goh, Wilford, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Koldej, Rachel, Gray, Daniel, Huang, David, Kile, Ben T., Lew, Andrew M., Ritchie, David S. and Huntington, Nicholas D. (2018). Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes. Cell Death & Differentiation, 26 (8), 1516-1530. doi: 10.1038/s41418-018-0228-y

  • Sun, Li, Rautela, Jai, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Carrington, Emma M., Schenk, Robyn L., Herold, Marco J., Huntington, Nicholas D., Lew, Andrew M., Xu, Yuekang and Zhan, Yifan (2018). GM-CSF quantity has a selective effect on granulocytic vs. monocytic myeloid development and function. Frontiers in Immunology, 9 1922. doi: 10.3389/fimmu.2018.01922

  • Parlato, Marianna, Philippart, François, Rouquette, Alexandra, Moucadel, Virginie, Puchois, Virginie, Blein, Sophie, Bedos, Jean-Pierre, Diehl, Jean-Luc, Hamzaoui, Olfa, Annane, Djillali, Journois, Didier, Ben Boutieb, Myriam, Estève, Laurent, Fitting, Catherine, Treluyer, Jean-Marc, Pachot, Alexandre, Adib-Conquy, Minou, Cavaillon, Jean-Marc, Misset, Benoît, Jacqmin, Sébastien, Lagrange, Alix, de Pinot de Villechenon, Gabrielle, Aissaoui, Nadia, Guerot, Emmanuel, Venot, Marion, Prat, Dominique, Sztrymf, Benjamin, Maxime, Virginie, Polito, Andrea ... Souza-Fonseca-Guimaraes, Fernando (2018). Circulating biomarkers may be unable to detect infection at the early phase of sepsis in ICU patients: the CAPTAIN prospective multicenter cohort study. Intensive Care Medicine, 44 (7), 1061-1070. doi: 10.1007/s00134-018-5228-3

  • Rautela, Jai, Souza-Fonseca-Guimaraes, Fernando, Hediyeh-Zadeh, Soroor, Delconte, Rebecca B., Davis, Melissa J. and Huntington, Nicholas D. (2018). Molecular insight into targeting the NK cell immune response to cancer. Immunology and Cell Biology, 96 (5), 477-484. doi: 10.1111/imcb.12045

  • Young, Arabella, Ngiow, Shin Foong, Gao, Yulong, Patch, Ann-Marie, Barkauskas, Deborah S., Messaoudene, Meriem, Lin, Gene, Coudert, Jerome D., Stannard, Kimberley A., Zitvogel, Laurence, Degli-Esposti, Mariapia A., Vivier, Eric, Waddell, Nicola, Linden, Joel, Huntington, Nicholas D., Souza-Fonseca-Guimaraes, Fernando and Smyth, Mark J. (2018). A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment. Cancer Research, 78 (4), 1003-1016. doi: 10.1158/0008-5472.CAN-17-2826

  • Ng, Susanna S., Souza-Fonseca-Guimaraes, Fernando, Rivera, Fabian de Labastida, Amante, Fiona H., Kumar, Rajiv, Gao, Yulong, Sheel, Meru, Beattie, Lynette, de Oca, Marcela Montes, Guillerey, Camille, Edwards, Chelsea L., Faleiro, Rebecca J., Frame, Teija, Bunn, Patrick T., Vivier, Eric, Godfrey, Dale I., Pellicci, Daniel G., Lopez, J. Alejandro, Andrews, Katherine T., Huntington, Nicholas D., Smyth, Mark J., McCarthy, James and Engwerda, Christian R. (2018). Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clinical and Translational Immunology, 7 (1) e1003, e1003. doi: 10.1002/cti2.1003

  • Souza-Fonseca-Guimaraes, Fernando and Huntington, Nicholas D. (2018). A new checkpoint for Natural Killer cell activation. Immunology and Cell Biology, 96 (1), 5-7. doi: 10.1111/imcb.1027

  • Gao, Yulong, Souza-Fonseca-Guimaraes, Fernando, Bald, Tobias, Ng, Susanna S., Young, Arabella, Ngiow, Shin Foong, Rautela, Jai, Straube, Jasmin, Waddell, Nic, Blake, Stephen J., Yan, Juming, Bartholin, Laurent, Lee, Jason S., Vivier, Eric, Takeda, Kazuyoshi, Messaoudene, Meriem, Zitvogel-, Laurence, Teng, Michele W. L., Belz, Gabrielle T., Engwerda, Christian R., Huntington, Nicholas D., Nakamura, Kyohei, Hoelzel, Michael and Smyth, Mark J. (2017). Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nature Immunology, 18 (9), 1004-1015. doi: 10.1038/ni.3800

  • Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K. H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D. and Smyth, Mark J. (2017). NK cell heparanase controls tumor invasion and immune surveillance. Journal of Clinical Investigation, 127 (7), 2777-2788. doi: 10.1172/JCI92958

  • Souza-Fonseca-Guimaraes, Paulo, Guimaraes, Fernando, de Souza-Araujo, Caroline Natânia, Leite, Lidiane Maria Boldrini, Senegaglia, Alexandra Cristina, Nishiyama, Anita and Souza-Fonseca-Guimaraes, Fernando (2017). Natural killer cell assessment in peripheral circulation and bronchoalveolar lavage fluid of patients with severe sepsis: a case control study. International Journal of Molecular Sciences, 18 (3) 616, 616. doi: 10.3390/ijms18030616

  • Lönnberg, Tapio, Svensson, Valentine, James, Kylie R., Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan S. F., Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Stubbington, Michael J. T., Ly, Lam-Ha, Bagger, Frederik Otzen, Zwiessele, Max, Lawrence, Neil D., Souza-Fonseca-Guimaraes, Fernando, Bunn, Patrick T., Engwerda, Christian R., Heath, William R., Billker, Oliver, Stegle, Oliver, Haque, Ashraful and Teichmann, Sarah A. (2017). Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria. Science Immunology, 2 (9) eaal2192, eaal2192. doi: 10.1126/sciimmunol.aal2192

  • Viant, Charlotte, Guia, Sophie, Hennessy, Robert J., Rautela, Jai, Pham, Kim, Bernat, Claire, Goh, Wilford, Jiao, Yuhao, Delconte, Rebecca, Roger, Michael, Simon, Vanina, Souza-Fonseca-Guimaraes, Fernando, Grabow, Stephanie, Belz, Gabrielle T., Kile, Benjamin T., Strasser, Andreas, Gray, Daniel, Hodgkin, Phillip D., Beutler, Bruce, Vivier, Eric, Ugolini, Sophie and Huntington, Nicholas D. (2017). Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival. Journal of Experimental Medicine, 214 (2), 491-510. doi: 10.1084/jem.20160869

  • Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P. A., Smyth, Mark J., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2017). GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood, 129 (5), 630-642. doi: 10.1182/blood-2016-08-734020

  • Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999

  • Le Texier, Laetitia, Lineburg, Katie E., Cao, Benjamin, McDonald-Hyman, Cameron, Leveque-El Mouttie, Lucie, Nicholls, Jemma, Melino, Michelle, Nalkurthi, Blessy C., Alexander, Kylie A., Teal, Bianca, Blake, Stephen J., Souza-Fonseca-Guimaraes, Fernando, Engwerda, Christian R., Kuns, Rachel D., Lane, Steven W., Teng, Michele, Teh, Charis, Gray, Daniel, Clouston, Andrew D., Nilsson, Susan K., Blazar, Bruce R., Hill, Geoffrey R. and MacDonald, Kelli P. A. (2016). Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease. JCI Insight, 1 (15) e86850, e86850. doi: 10.1172/jci.insight.86850

  • Souza-Fonseca-Guimaraes, Fernando, Blake, Stephen J., Makkouk, Amani, Chester, Cariad, Kohrt, Holbrook E. and Smyth, Mark J. (2016). Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity. OncoImmunology, 5 (7) e1192740, e1192740. doi: 10.1080/2162402X.2016.1192740

  • Souza-Fonseca-Guimaraes, F., Krasnova, Y., Putoczki, T., Miles, K., MacDonald, K. P., Town, L., Shi, W., Gobe, G. C., McDade, L., Mielke, L. A., Tye, H., Masters, S. L., Belz, G. T., Huntington, N. D., Radford-Smith, G. and Smyth, M. J. (2016). Granzyme M has a critical role in providing innate immune protection in ulcerative colitis. Cell Death and Disease, 7 (7) e2302, e2302-e2302. doi: 10.1038/cddis.2016.215

  • Souza-Fonseca-Guimaraes, Fernando (2016). NK cell-based immunotherapies: awakening the innate anti-cancer response. Discovery Medicine, 21 (115), 197-203.

  • Viel, Sebastien, Marcais, Antoine, Guimaraes, Fernando Souza-Fonseca, Loftus, Roisin, Rabilloud, Jessica, Grau, Morgan, Degouve, Sophie, Djebali, Sophia, Sanlaville, Amelien, Charrier, Emily, Bienvenu, Jacques, Marie, Julien C., Caux, Christophe, Marvel, Jacqueline, Town, Liam, Huntington, Nicholas D., Bartholin, Laurent, Finlay, David, Smyth, Mark J. and Walzer, Thierry (2016). TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway. Science Signaling, 9 (415) ra19, ra19-ra19. doi: 10.1126/scisignal.aad1884

  • Trojan, P. J.J., Bohatch-Junior, M. S., Otuki, M. F., Souza-Fonseca-Guimarães, F., Svidnicki, P. V., Nogaroto, V., Fernandes, D., Krum, E. A. and Favero, G. M. (2016). Pravastatina induz parada no ciclo celular e diminuição na produção de VEGF e bFGF em linhagem de mieloma multiplo. Brazilian Journal of Biology, 76 (1), 59-65. doi: 10.1590/1519-6984.11914

  • Krasnova, Yelena, Putz, Eva Maria, Smyth, Mark J. and Souza-Fonseca-Guimaraes, Fernando (2015). Bench to bedside: NK cells and control of metastasis. Clinical Immunology, 177, 50-59. doi: 10.1016/j.clim.2015.10.001

  • Souza-Fonseca-Guimaraes, Fernando, Young, Arabella, Mittal, Deepak, Martinet, Ludovic, Bruedigam, Claudia, Takeda, Kazuyoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Hill, Geoffrey R. and Smyth, Mark J. (2015). NK cells require IL-28R for optimal in vivo activity. Proceedings of the National Academy of Sciences of the United States of America, 112 (18), E2376-E2384. doi: 10.1073/pnas.1424241112

  • Martinet, Ludovic, FerrariDeAndrade, Lucas, Guillerey, Camille, Lee, Jason S, Liu, Jing, Souza-Fonseca-Guimaraes, Fernando, Hutchinson, Dana S, Kolesnik, Tatiana B, Nicholson, Sandra E, Huntington, Nicholas D and Smyth, Mark J (2015). DNAM-1 expression marks an alternative program of NK cell maturation. Cell Reports, 11 (1), 85-97. doi: 10.1016/j.celrep.2015.03.006

  • Paget, C., Chow, M. T., Gherardin, N. A., Beavis, P. A., Uldrich, A. P., Duret, H., Hassane, M., Souza-Fonseca-Guimaraes, F., Mogilenko, D. A., Staumont-Salle, D., Escalante, N. K., Hill, G. R., Neeson, P., Ritchie, D. S., Dombrowicz, D., Mallevaey, T., Trottein, F., Belz, G. T., Godfrey, D. I. and Smyth, M. J. (2015). CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells. Immunology and Cell Biology, 93 (2), 198-212. doi: 10.1038/icb.2014.94

  • Souza-Fonseca-Guimaraes, Fernando, Young, Arabella and Smyth, Mark J. (2015). IFN type III: In vivo NK cell response. Oncotarget, 6 (24), 19960-19961. doi: 10.18632/oncotarget.4758

  • Sathe, Priyanka, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Seillet, Cyril, Chopin, Michael, Vandenberg, Cassandra J., Rankin, Lucille C., Mielke, Lisa A., Vikstrom, Ingela, Kolesnik, Tatiana B., Nicholson, Sandra E., Vivier, Eric, Smyth, Mark J., Nutt, Stephen L., Glaser, Stefan P., Strasser, Andreas, Belz, Gabrielle T., Carotta, Sebastian and Huntington, Nicholas D. (2014). Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells. Nature Communications, 5 (1) 4539, 1-10. doi: 10.1038/ncomms5539

  • Parlato, Marianna, Souza-Fonseca-Guimaraes, Fernando, Philippart, François, Misset, Benoît, Adib-Conquy, Minou and Cavaillon, Jean-Marc (2014). CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. Journal of Immunology, 192 (5), 2449-2459. doi: 10.4049/jimmunol.1301055

  • Adib-Conquy, Minou, Scott-Algara, Daniel, Cavaillon, Jean-Marc and Souza-Fonseca-Guimaraes, Fernando (2014). TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals. Immunology and Cell Biology, 92 (3), 256-262. doi: 10.1038/icb.2013.99

  • Chan, Christopher J., Martinet, Ludovic, Gilfillan, Susan, Souza-Fonseca-Guimaraes, Fernando, Chow, Melvyn T., Town, Liam, Ritchie, David S., Colonna, Marco, Andrews, Daniel M. and Smyth, Mark J. (2014). The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nature Immunology, 15 (5), 431-438. doi: 10.1038/ni.2850

  • de Andrade, Lucas Ferrari, Biscaia, Stellee Marcela Petris, Rossi, Gustavo, Leck, Aline Raquell, da Costa, Cleber Rafael Vieira, Mozeleski, Brian, de Souza Fonseca Guimarães, Fernando, Zotz, Rafael, Gabardo, Juarez, de Oliveira, Carolina Camargo, de Freitas Buchi, Dorly and da Silva Trindade, Edvaldo (2013). Highly diluted natural complex M-1 inhibits melanoma growth in vivo. International Journal of High Dilution Research, 12 (44), 95-97.

  • Souza-Fonseca-Guimaraes, Fernando, Cavaillon, Jean-Marc and Adib-Conquy, Minou (2013). Bench-to-bedside review: natural killer cells in sepsis - guilty or not guilty?. Critical Care, 17 (4) 235. doi: 10.1186/cc12700

  • Souza-Fonseca-Guimaraes, Fernando and Smyth, Mark J. (2013). In the spotlight: myeloid TGF-beta responsiveness promotes metastases. Cancer Discovery, 3 (8), 846-848. doi: 10.1158/2159-8290.CD-13-0271

  • Souza-Fonseca-Guimaraes, Fernando, Parlato, Marianna, De Oliveira, Rosane B., Golenbock, Douglas, Fitzgerald, Katherine, Shalova, Irina N., Biswas, Subhra K., Cavaillon, Jean-Marc and Adib-Conquy, Minou (2013). Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING). Journal of Biological Chemistry, 288 (15), 10715-10721. doi: 10.1074/jbc.M112.435602

  • Souza-Fonseca-Guimaraes, Fernando, Parlato, Marianna, Philippart, François, Misset, Benoît, Cavaillon, Jean-Marc, Adib-Conquy, Minou, Jacqmin, Sébastien, Journois, Didier, Lagrange, Alix, de Villechenon, Gabrielle Pinot, Aissaoui, Nadia, Diehl, Jean-Luc, Guerot, Emmanuel, Venot, Marion, Hamzaoui, Olfa, Prat, Dominique, Sztrymf, Benjamin, Maxime, Djillali Annane Virginie, Polito, Andrea, Bournaud, Elsa, Bruel, Cédric, Fournier, Julien, Garrouste-Orgeas, Maïté, Gregoire, Charles, Lau, Nicolas, Max, Adeline, Bouhemad, Belaïd, Ethuin, Frédéric, Bedos, Jean-Pierre ... Moucadel, Virginie (2012). Toll-like receptors expression and interferon-γ production by NK cells in human sepsis. Critical Care, 16 (5) R206. doi: 10.1186/cc11838

  • Nowatzki, Jenifer, Sene, Reginaldo Vieira, Paludo, Katia Sabrina, Rizzo, Luiz Eduardo, Souza-Fonseca-Guimarães, Fernando, Veiga, Silvio Sanches, Nader, Helena Bonciani, Franco, Célia Regina C. and Trindade, Edvaldo S. (2012). Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis. Toxicon, 60 (3), 396-405. doi: 10.1016/j.toxicon.2012.04.333

  • Souza-Fonseca-Guimaraes, Fernando, Parlato, Marianna, Fitting, Catherine, Cavaillon, Jean-Marc and Adib-Conquy, Minou (2012). NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. Journal of Immunology, 188 (12), 5850-5858. doi: 10.4049/jimmunol.1103616

  • Kuczera, Diogo, Paro de Oliveira, Heloísa Helena, Fonseca Guimarães, Fernando de Souza, de Lima, Carina, Alves, Luciana, Machado, Andressa Franzói, Coelho, Isabela, Yamaguchi, Adriana, Donatti, Lucélia, Naliwaiko, Katya, Fernandes, Luiz Claudio and Nunes, Everson Araújo (2012). Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of Walker-256 tumor growth after β-hydroxy-β-methylbutyrate (HMB) administration in Wistar rats. Nutrition and Cancer, 64 (2), 286-293. doi: 10.1080/01635581.2012.647229

  • Rauh, Laryssa K., Horinouchi, Cíntia D.S., Loddi, Alliete M.V., Pietrovski, Evelise F., Neris, Rosalina, Souza-Fonseca-Guimarães, Fernando, Buchi, Dorly F., Biavatti, Maique W., Otuki, Michel F. and Cabrini, Daniela A. (2011). Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes. Journal of Ethnopharmacology, 138 (2), 390-397. doi: 10.1016/j.jep.2011.09.012

  • Souza-Fonseca-Guimaraes, Fernando, Adib-Conquy, Minou and Cavaillon, Jean-Marc (2011). Natural killer (NK) cells in antibacterial innate immunity: angels or devils?. Molecular Medicine, 18 (1), 270-285. doi: 10.2119/molmed.2011.00201

  • de Oliveira, Carolina C., Abud, Ana P. R., de Oliveira, Simone M., de SF Guimarães, Fernando, de Andrade, Lucas F., Di Bernardi, Raffaello P., de O Coletto, Ediely L., Kuczera, Diogo, Da Lozzo, Eneida J., Gonçalves, Jenifer P., da S Trindade, Edvaldo and de F Buchi, Dorly (2011). Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complementary and Alternative Medicine, 11 (1) 101. doi: 10.1186/1472-6882-11-101

  • Pietrovski, Evelise Fernandes, Paludo, Kátia Sabrina, Mendes, Daniel Augusto Gasparin Bueno, de Souza Fonseca Guimarães, Fernando, Veiga, Silvio Sanchez, de Freitas Buchi, Dorly, Fonseca, Raphael Gomes, Zampronio, Aleksander Roberto, Bader, Michael, Pesquero, João Bosco, Ferreira, Juliano, Otuki, Michel Fleith and Cabrini, Daniela Almeida (2011). B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice. Journal of Dermatological Science, 64 (1), 23-30. doi: 10.1016/j.jdermsci.2011.06.016

  • Guimarães, Fernando S.F., Andrade, Lucas F., Martins, Sharon T., Abud, Ana P.R., Sene, Reginaldo V., Wanderer, Carla, Tiscornia, Inés, Bollati-Fogolín, Mariela, Buchi, Dorly F. and Trindade, Edvaldo S. (2010). In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model. BMC Cancer, 10 (1) 113. doi: 10.1186/1471-2407-10-113

  • Guimaraes, Fernando De S. F., De Oliveira, Simone M., De Oliveira, Carolina C., Donatti, Lucelia and Buchi, Dorly De Freitas (2009). A shorter fixation protocol for transmission electron microscopy: An alternative to spend less time. Ultrastructural Pathology, 33 (4), 169-174. doi: 10.3109/01913120902889153

  • Noleto, Rafael Bueno, de Fonseca Souza Guimarães, Fernando, Paludo, Katia Sabrina, Vicari, Marcelo Ricardo, Artoni, Roberto Ferreira and Cestari, Marta Margarete (2009). Genome size evaluation in tetraodontiform fishes from the neotropical region. Marine Biotechnology, 11 (6), 680-685. doi: 10.1007/s10126-009-9215-0

  • Ramsdorf, Wanessa A., Guimarães, Fernando de S.F., Ferraro, Marcos V.M., Gabardo, Juarez, Trindade, Edvaldo da Silva and Cestari, Marta Margarete (2009). Establishment of experimental conditions for preserving samples of fish blood for analysis with both comet assay and flow cytometry. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 673 (1), 78-81. doi: 10.1016/j.mrgentox.2008.11.010

Conference Publication

  • Souza-Fonseca-Guimaraes, Fernando, Rossi, Gustavo Rodrigues, Wells, Timothy and McCulloch, Timothy Ryan (2023). TIGIT limits anti-bacterial immunity and is a potential target for immunotherapy. IMMUNOLOGY2023™ Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: The American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.64.14

  • Kulasinghe, Arutha, Tan, Chin Wee, Liu, Ning, Monkman, James, Killingbeck, Emily, Kim, Youngmi, Pan, Liuliu, Blick, Tony, Bhuva, Dharmesh, Feher, Kristen, Leon, Michael, Gregory, Mark, Short, Kirsty, Guimaraes, Fernando, Rhodes, Michael, Belz, Gabrielle and Davis, Melissa (2022). Deep single-cell, proteogenomic insights from SARS-CoV-2 infected lung tissues. SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0923

  • Ma, Ning, Braubach, Oliver, Rebutini, Patricia Zadorosnei, Machado-Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, de Noronha, Lucia, Souza-Fonseca-Guimaraes, Fernando and Kulasinghe, Arutha (2022). Mapping the spatial biology of COVID-19 immunopathology in placenta tissues. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.125.20

  • Souza-Fonseca-Guimaraes, Fernando (2022). TGF-β and CIS inhibition synergistically enhance natural killer cell-based immunity. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.164.01

  • Austin, Rebecca, Bywater, Megan, Straube, Jasmin, Cooper, Leanne T., Headlam, Madeleine, Dave, Keyur, Braun, Matthias, Bald, Tobias, Guimaraes, Fernando, Jacquelin, Sebastien, Witkowski, Matthew, Aifantis, Iannis, Hill, Geoffrey R., Smyth, Mark J. and Lane, Steven W. (2018). Oncogenic-Drivers Dictate Immune Responses to Control Disease Progression in Acute Myeloid Leukaemia. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 1-4 December 2018. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2018-99-112009

  • MacDonald, Kelli P. A., Le Texier, Laetitia, Leveque-ElMouttie, Lucie, Lineburg, Katie, Nicholls, Jemma, Guimaraes, Fernando Souza-Fonseca, Alexander, Kylie, Clouston, Andrew, Blazar, Bruce R. and Hill, Geoff R. (2016). Autophagy-dependent TIGIT+ Treg are critical for the maintenance of tolerance. Immunology 2016 Meeting, Seattle, WA United States, 13-17 May 2016. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.196.supp.125.14

  • Young, A., Souza-Fonseca-Guimaraes, F., Ngiow, S. F., Gao, Y., Linden, J., Huntington, N. D. and Smyth, M. J. (2016). Adenosine impairs the proliferative capacity of terminally mature NK cells. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

  • Kumar, V., Woodruff, T., Ting, M., Boyd, A., Coulthard, M., Souza-Fonseca-Guimaraes, F. and Smyth, M. (2016). EphA2KO mice survive longer in a mouse model of sepsis. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

  • Putz, E. M., Souza-Fonseca-Guimaraes, F., Barkauskas, D. S., Town, L., Hulett, M. D. and Smyth, M. J. (2016). The role of heparanase in NK cell migration and NK cell-mediated tumour surveillance. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200

  • Souza-Fonseca-Guimaraes, Fernando, Martinet, Ludovic, Hill, Geoffrey R., Teng, Michele W. L. and Smyth, Mark (2014). Checkpoints and interferons in tumor control. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, Australia, 26-29 October 2014. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2014.07.244

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Background: Despite advances in treatment and earlier detection, cancer is still a main cause of cancer death worldwide. Natural killer (NK) cells are circulating innate lymphocytes that naturally protect against tumor spread (metastasis), and recently showed by our group as dysfunctional in the tumour microenvironment (TME) established by cancers at distant organs for future metastatic spread. Yet, despite knowing that NK cells do control cancer metastasis, our knowledge of how cancer cells evade NK cell control is still very poor. This project aims to examine several immune suppressive pathways that cancers likely manipulate to avoid NK cells and spread. These include factors the transforming growth factor (TGF)-β superfamily that are elevated in the tumor environment. These molecules have great potential to suppress the normally high killing and anti-metastatic activity mediated by NK cells, but to date we still need to elucidate how relatively important each pathway might be.

    Proposed research program: The intrinsic NK cell function under suppressive factors stimulation will be assessed with NK cells purified from mouse spleen (wild type) by cell sorter, and in vitro challenge with activating cytokines and suppressive factors. Aim-1: Which suppressive factor is a major inhibitor of NK cell killing activity? This aim will be screened by killing activity of NK cells versus target tumour cells in co-culture systems. Aim-2: Which suppressive factor is a major inhibitor of NK cell cytokine secretion? This aim will assess NK cell cytokine production by intracellular cytokine (e.g. IFN-gamma) staining (flow cytometry) and secreted IFN-gamma, among others, from culture supernatants (ELISA); Aim-3: What is the cellular signalling status under suppressive conditions? The identification of altered cellular signalling will be screened by intracellular staining of phosphorylated signalling molecules (phosphor(p)-AKT, p-ERK1/2, p-p38, p-phospholipase C-gamma2, p-phosphotyrosine, p-SMAD2,3, p-STAT4, p-STAT5 and p-ZAP70 (PhosphoFlow).

    These experimental tools will determine which is the most important suppressive pathway in inhibiting NK cell functions. Information we obtain from this work will allow us to design rationale approaches to increase NK cell function in personalised immunotherapy approaches.