The University of Queensland

International pediatric COVID-19 severity over the course of the pandemic

Zhu, Yanshan, Almeida, Flávia Jacqueline, Baillie, J Kenneth, Bowen, Asha C, Britton, Philip N, Brizuela, Martin Eduardo, Buonsenso, Danilo, Burgner, David, Chew, Keng Yih, Chokephaibulkit, Kulkanya, Cohen, Cheryl, Cormier, Stephania A, Crawford, Nigel, Curtis, Nigel, Farias, Camila G A, Gilks, Charles F, von Gottberg, Anne, Hamer, Diana, Jarovsky, Daniel, Jassat, Waasila, Jesus, Ana Rita, Kemp, Lisa S, Khumcha, Benjawan, McCallum, Georgina, Miller, Jessica E, Morello, Rosa, Munro, Alasdair P S, Openshaw, Peter J M, Padmanabhan, Srivatsan ... For the International Severe Acute Respiratory Infection Consortium (ISARIC4C) groupPediatric Active Enhanced Disease Surveillance (PAEDS) Network group (2023). International pediatric COVID-19 severity over the course of the pandemic. JAMA Pediatrics, 177 (10), 1073-1084. doi: 10.1001/jamapediatrics.2023.3117

In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

Tu, Wen Juan, Melino, Michelle, Dunn, Jenny, McCuaig, Robert D., Bielefeldt-Ohmann, Helle, Tsimbalyuk, Sofiya, Forwood, Jade K., Ahuja, Taniya, Vandermeide, John, Tan, Xiao, Tran, Minh, Nguyen, Quan, Zhang, Liang, Nam, Andy, Pan, Liuliu, Liang, Yan, Smith, Corey, Lineburg, Katie, Nguyen, Tam H., Sng, Julian D. J., Tong, Zhen Wei Marcus, Chew, Keng Yih, Short, Kirsty R., Le Grand, Roger, Seddiki, Nabila and Rao, Sudha (2023). In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting. Nature Communications, 14 (1) 3680, 3680. doi: 10.1038/s41467-023-39341-4

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Martínez-Mármol, Ramón, Giordano-Santini, Rosina, Kaulich, Eva, Cho, Ann-Na, Przybyla, Magdalena, Riyadh, Md Asrafuzzaman, Robinson, Emilija, Chew, Keng Yih, Amor, Rumelo, Meunier, Frédéric A., Balistreri, Giuseppe, Short, Kirsty R., Ke, Yazi D., Ittner, Lars M. and Hilliard, Massimo A. (2023). SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Science Advances, 9 (23) eadg2248, 1-15. doi: 10.1126/sciadv.adg2248

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium

Yamamoto, Ayaho, Sly, Peter D., Chew, Keng Yih, Khachatryan, Lavrent, Begum, Nelufa, Yeo, Abrey J., Vu, Luan D, Short, Kirsty R., Cormier, Stephania A and Fantino, Emmanuelle (2023). Environmentally persistent free radicals enhance SARS-CoV-2 replication in respiratory epithelium. Experimental Biology and Medicine, 248 (3), 271-279. doi: 10.1177/15353702221142616

The swan genome and transcriptome, it is not all black and white

Karawita, Anjana C., Cheng, Yuanyuan, Chew, Keng Yih, Challagulla, Arjun, Kraus, Robert, Mueller, Ralf C., Tong, Marcus Z. W., Hulme, Katina D., Bielefeldt-Ohmann, Helle, Steele, Lauren E., Wu, Melanie, Sng, Julian, Noye, Ellesandra, Bruxner, Timothy J., Au, Gough G., Lowther, Suzanne, Blommaert, Julie, Suh, Alexander, McCauley, Alexander J., Kaur, Parwinder, Dudchenko, Olga, Aiden, Erez, Fedrigo, Olivier, Formenti, Giulio, Mountcastle, Jacquelyn, Chow, William, Martin, Fergal J., Ogeh, Denye N., Thiaud-Nissen, Françoise ... Short, Kirsty R. (2023). The swan genome and transcriptome, it is not all black and white. Genome Biology, 24 (1) 13, 1-24. doi: 10.1186/s13059-022-02838-0

IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study

Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin ... Tang, Benjamin (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13 1060438, 1-14. doi: 10.3389/fimmu.2022.1060438

GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection

Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022

Developing an antiviral surface cleaner utilising unique surface adsorption properties of hydroxyproline-rich-proteins

Shewan, Heather M. , Siauw, Meiliana , Vinden, Naomi , Dong, Anran , Beheshti, Amir , Chew, Keng Yih, Stokes, Jason R. , Short, Kirsty R., Mikkelsen, Deirdre, Koehler, Berthold and Reihmann, Matthias (2022). Developing an antiviral surface cleaner utilising unique surface adsorption properties of hydroxyproline-rich-proteins. Household and Personal Care Today, 17 (5), 57-61.

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Zhu, Yanshan, Chew, Keng Yih, Wu, Melanie, Karawita, Anjana C., McCallum, Georgina, Steele, Lauren E., Yamamoto, Ayaho, Labzin, Larisa I., Yarlagadda, Tejasri, Khromykh, Alexander A., Wang, Xiaohui, Sng, Julian D. J., Stocks, Claudia J., Xia, Yao, Kollmann, Tobias R., Martino, David, Joensuu, Merja, Meunier, Frédéric A., Balistreri, Giuseppe, Bielefeldt-Ohmann, Helle, Bowen, Asha C., Kicic, Anthony, Sly, Peter D., Spann, Kirsten M. and Short, Kirsty R. (2022). Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells. PLoS Biology, 20 (8) e3001728, 1-19. doi: 10.1371/journal.pbio.3001728

Limited recognition of highly conserved regions of SARS-CoV-2

Swaminathan, Srividhya, Lineburg, Katie E., Ambalathingal, George R., Crooks, Pauline, Grant, Emma J., Mohan, Sonali V., Raju, Jyothy, Panikkar, Archana, Le Texier, Laetitia, Tong, Zheng Wei Marcus, Chew, Keng Yih, Neller, Michelle A., Short, Kirsty R., Gowda, Harsha, Gras, Stephanie, Khanna, Rajiv and Smith, Corey (2022). Limited recognition of highly conserved regions of SARS-CoV-2. Microbiology Spectrum, 10 (1) e02780-21. doi: 10.1128/spectrum.02780-21

SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants

Panikkar, Archana, Lineburg, Katie E., Raju, Jyothy, Chew, Keng Yih, Ambalathingal, George R., Rehan, Sweera, Swaminathan, Srividhya, Crooks, Pauline, Le Texier, Laetitia, Beagley, Leone, Best, Shannon, Solomon, Matthew, Matthews, Katherine K., Srihari, Sriganesh, Neller, Michelle A., Short, Kirsty R., Khanna, Rajiv and Smith, Corey (2022). SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variants. PLoS Pathogens, 18 (2) e1010339, 1-18. doi: 10.1371/journal.ppat.1010339

Endothelial cells are not productively infected by SARS‐CoV‐2

Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350

Type I diabetes mellitus increases the cardiovascular complications of influenza virus infection

Sinclair, Jane E., Bloxham, Conor J., Chiu, Han, Chew, Keng Yih, Russell, Jake, Yoshikawa, Yusuke, Bielefeldt-Ohmann, Helle, Steele, Lauren E., Hulme, Katina D., Verzele, Nathalie A. J., Noye, Ellesandra C., Wu, Melanie, Reichelt, Melissa E., Thomas, Walter G., Gallo, Linda A., Redd, Meredith A. and Short, Kirsty R. (2021). Type I diabetes mellitus increases the cardiovascular complications of influenza virus infection. Frontiers in Cellular and Infection Microbiology, 11 714440, 714440. doi: 10.3389/fcimb.2021.714440

Limited evidence for the role of environmental factors in the unusual peak of influenza in Brisbane during the 2018-2019 Australian summer

Lu, Jianyun, Yang, Zhicong, Karawita, Anjana C., Bunte, Myrna, Chew, Keng Yih, Pegg, Cassandra, Mackay, Ian, Whiley, David and Short, Kirsty R. (2021). Limited evidence for the role of environmental factors in the unusual peak of influenza in Brisbane during the 2018-2019 Australian summer. The Science of the Total Environment, 776 145967, 145967. doi: 10.1016/j.scitotenv.2021.145967

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Zhu, Yanshan, Bloxham, Conor J., Hulme, Katina D., Sinclair, Jane E., Tong, Zhen Wei Marcus, Steele, Lauren E., Noye, Ellesandra C., Lu, Jiahai, Xia, Yao, Chew, Keng Yih, Pickering, Janessa, Gilks, Charles, Bowen, Asha C. and Short, Kirsty R. (2021). A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters. Clinical Infectious Diseases, 72 (12) ciaa1825, e1146-e1153. doi: 10.1093/cid/ciaa1825

Primary chicken and duck endothelial cells display a differential response to infection with highly pathogenic avian influenza virus​​​​​​​

Tong, Zhen Wei Marcus, Karawita, Anjana C., Kern, Colin, Zhou, Huaijun, Sinclair, Jane E., Yan, Limin, Chew, Keng Yih, Lowther, Sue, Trinidad, Lee, Challagulla, Arjun, Schat, Karel A., Baker, Michelle L. and Short, Kirsty R. (2021). Primary chicken and duck endothelial cells display a differential response to infection with highly pathogenic avian influenza virus​​​​​​​. Genes, 12 (6) 901, 901. doi: 10.3390/genes12060901

CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses

Lineburg, Katie E., Grant, Emma J., Swaminathan, Srividhya, Chatzileontiadou, Demetra S.M., Szeto, Christopher, Sloane, Hannah, Panikkar, Archana, Raju, Jyothy, Crooks, Pauline, Rehan, Sweera, Nguyen, Andrea T., Lekieffre, Lea, Neller, Michelle A., Tong, Zhen Wei Marcus, Jayasinghe, Dhilshan, Chew, Keng Yih, Lobos, Christian A., Halim, Hanim, Burrows, Jacqueline M., Riboldi-Tunnicliffe, Alan, Chen, Weisan, D'Orsogna, Lloyd, Khanna, Rajiv, Short, Kirsty R., Smith, Corey and Gras, Stephanie (2021). CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses. Immunity, 54 (5), 1055-1065. doi: 10.1016/j.immuni.2021.04.006

A high fat diet increases influenza A virus-associated cardiovascular damage

Siegers, Jurre Y., Novakovic, Boris, Hulme, Katina D., Marshall, Rebecca, Bloxham, Conor J., Thomas, Walter G., Reichelt, Mellissa E., Leijten, Lonneke, van Run, Peter, Knox, Karen, Sokolowski, Kamil A., Tse, Brian W. C., Chew, Keng Yih, Christ, Angelika N., Howe, Greg, Bruxner, Timothy J. C., Karolyi, Mario, Pawelka, Erich, Koch, Rebecca M., Bellmann-Weiler, Rosa, Burkert, Francesco, Weiss, Günter, Samanta, Romit J., Openshaw, Peter J. M., Bielefeldt-Ohmann, Helle, van Riel, Debby and Short, Kirsty R. (2020). A high fat diet increases influenza A virus-associated cardiovascular damage. The Journal of infectious diseases, 222 (5), 820-831. doi: 10.1093/infdis/jiaa159

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907

Glycemic variability in diabetes increases the severity of influenza

Marshall, Rebecca J., Armart, Pornthida, Hulme, Katina D., Chew, Keng Yih, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A. and Short, Kirsty R. (2020). Glycemic variability in diabetes increases the severity of influenza. mBio, 11 (2) e02841-19. doi: 10.1128/mbio.02841-19

Emulation of epidemics via Bluetooth-based virtual safe virus spread: experimental setup, software, and data

Asanjarani, Azam, Shausan, Aminath, Chew, Keng, Graham, Thomas, Henderson, Shane G., Jansen, Hermanus M., Short, Kirsty R., Taylor, Peter G., Vuorinen, Aapeli, Yadav, Yuvraj, Ziedins, Ilze and Nazarathy, Yoni (2022). Emulation of epidemics via Bluetooth-based virtual safe virus spread: experimental setup, software, and data.