Dr Camille Guillerey

Honorary Senior Research Fellow

Mater Research Institute-UQ
Faculty of Medicine

Overview

Dr Camille Guillerey is a Senior Research Officer in the Cancer Immunotherapies laboratory at Mater Research. She leads a small team of researchers and students.

Dr Guillerey completed her PhD in Immunology at the Pasteur Institute of Paris, France. In 2014, she moved to Australia to study Cancer Immunonology at QIMR Berghofer Medical Research Institute. Dr Guillerey joined Kristen Radford's laboratory at Mater Research in November 2018 to establish an independent research program investigating immune responses to hematological cancers.

Dr Guillerey's research is currently focused on Natural Killer cells, a population of immune cells that recognise and kill cancer cells. She aims to identify mechanisms that may prevent Natural Killer cells from eliminating cancer cells and apply these findings to develop new treatments for childhood leukemia.

Research Impacts

Dr Guillerey has authored 28 publications, and has received more than $1,7M in competitive funding from NHMRC, Cancer Australia, Cure Cancer Australia. Leukaemia Foundation and the Children Hospital Foundation. Through this research, Dr Guillerey has made integral contributions to improve knowledge on immune responses to blood cancers. She identified the immune molecules TIGIT and CD137 as promising targets in immune multiple myeloma, an incurable blood cancer. Her research contributions have been recognized with her nomination as a finalist for the 2019 Women in Technology rising star award.

Qualifications

  • Doctor of Philosophy, University of Paris

Publications

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Guillerey, Camille (2020). NK cells in the tumor microenvironment. Tumor microenvironment: hematopoietic cells – part B. (pp. 69-90) edited by Alexander Birbrair. Cham, Switzerland: Springer . doi: 10.1007/978-3-030-49270-0_4

  • Guillerey, Camille and Smyth, Mark J. (2016). NK cells and cancer immunoediting. Natural killer cells. (pp. 115-145) edited by Eric Vivier, James Di Santo and Alessandro Moretta. [Cham], Switzerland: Springer. doi: 10.1007/82_2015_446

Journal Article

  • Liam, O'Brien, Carina, Walpole, Ingrid, Leal-Rojas, Svetlana, Shatunova, Andrew, Moore, Winkler, Ingrid G, Camille, Guillerey and Radford, Kristen J (2023). Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells. Experimental Hematology, 130 104134, 104134. doi: 10.1016/j.exphem.2023.11.008

  • Pichler, Andrea C., Carrié, Nadège, Cuisinier, Marine, Ghazali, Samira, Voisin, Alison, Axisa, Pierre-Paul, Tosolini, Marie, Mazzotti, Céline, Golec, Dominic P., Maheo, Sabrina, do Souto, Laura, Ekren, Rüçhan, Blanquart, Eve, Lemaitre, Lea, Feliu, Virginie, Joubert, Marie-Véronique, Cannons, Jennifer L., Guillerey, Camille, Avet-Loiseau, Hervé, Watts, Tania H., Salomon, Benoit L., Joffre, Olivier, Grinberg-Bleyer, Yenkel, Schwarzberg, Pamela L., Lucca, Liliana E. and Martinet, Ludovic (2023). TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation. Immunity, 56 (7), 1631-1648.e10. doi: 10.1016/j.immuni.2023.06.007

  • Buckle, Irina, Johnson, Anthony, Rojas, Ingrid Leal, Weinert, Vicky, Sester, David P., Radford, Kristen and Guillerey, Camille (2023). High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood. European Journal of Immunology, 53 (6) 2250118, 1-13. doi: 10.1002/eji.202250118

  • Buckle, Irina and Guillerey, Camille (2021). Inhibitory receptors and immune checkpoints regulating natural killer cell responses to cancer. Cancers, 13 (17) 4263. doi: 10.3390/cancers13174263

  • Weulersse, Marianne, Asrir, Assia, Pichler, Andrea C., Lemaitre, Lea, Braun, Matthias, Carrié, Nadège, Joubert, Marie-Véronique, Le Moine, Marie, Do Souto, Laura, Gaud, Guillaume, Das, Indrajit, Brauns, Elisa, Scarlata, Clara M., Morandi, Elena, Sundarrajan, Ashmitha, Cuisinier, Marine, Buisson, Laure, Maheo, Sabrina, Kassem, Sahar, Agesta, Arantxa, Pérès, Michaël, Verhoeyen, Els, Martinez, Alejandra, Mazieres, Julien, Dupré, Loïc, Gossye, Thomas, Pancaldi, Vera, Guillerey, Camille, Ayyoub, Maha ... Martinet, Ludovic (2020). Eomes-dependent loss of the co-activating receptor CD226 restrains CD8+ T cell anti-tumor functions and limits the efficacy of cancer immunotherapy. Immunity, 53 (4), 824-839.e10. doi: 10.1016/j.immuni.2020.09.006

  • Guillerey, Camille, Stannard, Kimberley, Chen, Jason, Krumeich, Sophie, Miles, Kim, Nakamura, Kyohei, Smith, Jessica, Yu, Yuan, Ng, Susanna, Harjunpää, Heidi, Teng, Michele W. L., Engwerda, Christian, Belz, Gabrielle T. and Smyth, Mark J. (2020). Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma. Immunology and Cell Biology, 99 (1) imcb.12390, 65-83. doi: 10.1111/imcb.12390

  • Harjunpaeae, H. and Guillerey, C. (2019). TIGIT as an emerging immune checkpoint. Clinical and Experimental Immunology, 200 (2) cei.13407, 108-119. doi: 10.1111/cei.13407

  • Guillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C., Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I., Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele W.L., Bergsagel, P. Leif, Chesi, Marta, Hill, Geoffrey R., Martinet, Ludovic and Smyth, Mark J. (2019). Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. JCI Insight, 4 (14) :e125932. doi: 10.1172/jci.insight.125932

  • O’Brien, Liam J., Guillerey, Camille and Radford, Kristen J. (2019). Can Dendritic Cell vaccination prevent leukemia relapse?. Cancers, 11 (6) 875, 875. doi: 10.3390/cancers11060875

  • Stannard, Kimberley A., Lemoine, Sébastien, Waterhouse, Nigel J., Vari, Frank, Chatenoud, Lucienne, Gandhi, Maher K., Martinet, Ludovic, Smyth, Mark J. and Guillerey, Camille (2019). Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions. Blood Advances, 3 (11), 1681-1694. doi: 10.1182/bloodadvances.2018030676

  • Guillerey, Camille (2018). Roles of cytotoxic and helper innate lymphoid cells in cancer. Mammalian Genome, 29 (11-12), 777-789. doi: 10.1007/s00335-018-9781-4

  • Minnie, Simone A., Kuns, Rachel D., Gartlan, Kate H., Zhang, Ping, Wilkinson, Andrew N., Samson, Luke, Guillerey, Camille, Engwerda, Christian, MacDonald, Kelli P. A., Smyth, Mark J., Markey, Kate A., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade. Blood, 132 (16), 1675-1688. doi: 10.1182/blood-2018-01-825240

  • Vuckovic, Slavica, Minnie, Simone A., Smith, David, Gartlan, Kate H., Watkins, Thomas S., Markey, Kate A., Mukhopadhyay, Pamela, Guillerey, Camille, Kuns, Rachel D., Locke, Kelly R., Pritchard, Antonia L., Johansson, Peter A., Varelias, Antiopi, Zhang, Ping, Huntington, Nicholas D., Waddell, Nicola, Chesi, Marta, Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Bone marrow transplantation generates T cell–dependent control of myeloma in mice. Journal of Clinical Investigation, 129 (1) CI98888, 106-121. doi: 10.1172/jci98888

  • Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W. L., Nakamura, Kyohei, Martinet, Ludovic and Smyth, Mark J. (2018). TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma. Blood, 132 (16), blood-2018. doi: 10.1182/blood-2018-01-825265

  • Oberkampf, Marine, Guillerey, Camille, Mouriès, Juliette, Rosenbaum, Pierre, Fayolle, Catherine, Bobard, Alexandre, Savina, Ariel, Ogier-Denis, Eric, Enninga, Jost, Amigorena, Sebastian, Leclerc, Claude and Dadaglio, Gilles (2018). Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nature Communications, 9 (1) 2241, 2241. doi: 10.1038/s41467-018-04686-8

  • Terra, Mariana, Oberkampf, Marine, Fayolle, Catherine, Rosenbaum, Pierre, Guillerey, Camille, Dadaglio, Gilles and Leclerc, Claude (2018). Tumor-derived TGFb alters the ability of plasmacytoid dendritic cells to respond to innate immune signaling. Cancer Research, 78 (11), 3014-3026. doi: 10.1158/0008-5472.CAN-17-2719

  • Minnie, Simone, Vuckovic, Slavica, Smith, David, Gartlan, Kate H., Watkins, Thomas S., Kuns, Rachel D., Guillerey, Camille, Chesi, Marta, Markey, Kate A., Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium. The Journal of Immunology, 200 (1_Supplement), 55.19-55.19. doi: 10.4049/jimmunol.200.supp.55.19

  • Harjunpää, Heidi, Blake, Stephen J., Ahern, Elizabeth, Allen, Stacey, Liu, Jing, Yan, Juming, Lutzky, Viviana, Takeda, Kazuyoshi, Aguilera, Amy Roman, Guillerey, Camille, Mittal, Deepak, Li, Xian Yang, Dougall, William C., Smyth, Mark J. and Teng, Michele W. L. (2018). Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis. OncoImmunology, 7 (7) e1445949, e1445949. doi: 10.1080/2162402X.2018.1445949

  • Nakamura, Kyohei, Kassem, Sahar, Cleynen, Alice, Chrétien, Marie-Lorraine, Guillerey, Camille, Putz, Eva Maria, Bald, Tobias, Förster, Irmgard, Vuckovic, Slavica, Hill, Geoffrey R, Masters, Seth L, Chesi, Marta, Bergsagel, P Leif, Avet-Loiseau, Hervé, Martinet, Ludovic and Smyth, Mark J. (2018). Dysregulated IL-18 Is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment. Cancer Cell, 33 (4), 634-648. doi: 10.1016/j.ccell.2018.02.007

  • Ng, Susanna S., Souza-Fonseca-Guimaraes, Fernando, Rivera, Fabian de Labastida, Amante, Fiona H., Kumar, Rajiv, Gao, Yulong, Sheel, Meru, Beattie, Lynette, de Oca, Marcela Montes, Guillerey, Camille, Edwards, Chelsea L., Faleiro, Rebecca J., Frame, Teija, Bunn, Patrick T., Vivier, Eric, Godfrey, Dale I., Pellicci, Daniel G., Lopez, J. Alejandro, Andrews, Katherine T., Huntington, Nicholas D., Smyth, Mark J., McCarthy, James and Engwerda, Christian R. (2018). Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clinical and Translational Immunology, 7 (1) e1003, e1003. doi: 10.1002/cti2.1003

  • Guillerey, Camille and Smyth, Mark J. (2017). Cytokine-driven role of Srebps in killer cell metabolism. Nature Immunology, 18 (11), 1183-1184. doi: 10.1038/ni.3855

  • Putz, Eva M., Guillerey, Camille, Kos, Kevin, Stannard, Kimberley, Miles, Kim, Delconte, Rebecca B, Takeda, Kazuyoshi, Nicholson, Sandra E., Huntington, Nicholas D. and Smyth, Mark J. (2017). Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis. OncoImmunology, 6 (2) e1267892, e1267892. doi: 10.1080/2162402X.2016.1267892

  • Guillerey, Camille, Huntington, Nicholas D. and Smyth, Mark J. (2016). Targeting natural killer cells in cancer immunotherapy. Nature Immunology, 17 (9), 1025-1036. doi: 10.1038/ni.3518

  • Guillerey, Camille, Nakamura, Kyohei, Vuckovic, Slavica, Hill, Geoffrey R. and Smyth, Mark J. (2016). Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies. Cellular and Molecular Life Sciences, 73 (8), 1569-1589. doi: 10.1007/s00018-016-2135-z

  • Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Marta, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (7), 2904-2904. doi: 10.1172/JCI82646

  • Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Martha, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (5), 2077-2089. doi: 10.1172/JCI77181

  • Martinet, Ludovic, FerrariDeAndrade, Lucas, Guillerey, Camille, Lee, Jason S, Liu, Jing, Souza-Fonseca-Guimaraes, Fernando, Hutchinson, Dana S, Kolesnik, Tatiana B, Nicholson, Sandra E, Huntington, Nicholas D and Smyth, Mark J (2015). DNAM-1 expression marks an alternative program of NK cell maturation. Cell Reports, 11 (1), 85-97. doi: 10.1016/j.celrep.2015.03.006

  • Guillerey, Camille, Chow, Melvyn T., Miles, Kim, Olver, Stuart, Sceneay, Jaclyn, Takeda, Kazuyoshi, Möller, Andreas and Smyth, Mark J. (2015). Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis. Oncoimmunology, 4 (9), 1-11. doi: 10.1080/2162402X.2015.1027468

  • Guillerey, Camille, Mouries̀, Juliette, Polo, Giulia, Doyen, Noelle, Law, Helen K. W., Chan, Susan, Kastner, Philippe, Leclerc, Claude and Dadaglio, Gilles (2012). Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Blood, 120 (1), 90-99. doi: 10.1182/blood-2012-02-410936

  • Renault, Valérie M., Rafalski, Victoria A., Morgan, Alex A., Salih, Dervis A.M., Brett, Jamie O., Webb, Ashley E., Villeda, Saul A., Thekkat, Pramod U., Guillerey, Camille, Denko, Nicholas C., Palmer, Theo D., Butte, Atul J. and Brunet, Anne (2009). FoxO3 Regulates Neural Stem Cell Homeostasis. Cell Stem Cell, 5 (5), 527-539. doi: 10.1016/j.stem.2009.09.014

Conference Publication

  • Minnie, Simone, Vuckovic, Slavica, Smith, David, Gartlan, Kate H., Watkins, Thomas S., Kuns, Rachel D., Guillerey, Camille, Chesi, Marta, Markey, Kate A., Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium. Immunology Meeting, Austin, TX, United States, 4-8 May, 2018. Rockville, MD, United States: American Association of Immunologists.

  • Guillerey, C., de Andrade, L. F., Miles, K., Vuckovic, S., Chesi, M., Bergsagel, L. P., Geoffrey, R. H., Martinet, L. and Smyth, M. J. (2016). Therapeutic potential anti-CD137 mAbs in multiple myeloma. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH.

Grants (Administered at UQ)

PhD and MPhil Supervision

Note for students: Dr Camille Guillerey is not currently available to take on new students.

Current Supervision

Completed Supervision