The University of Queensland

NK cells in the tumor microenvironment

Guillerey, Camille (2020). NK cells in the tumor microenvironment. Tumor microenvironment: hematopoietic cells – part B. (pp. 69-90) edited by Alexander Birbrair. Cham, Switzerland: Springer . doi: 10.1007/978-3-030-49270-0_4

NK cells and cancer immunoediting

Guillerey, Camille and Smyth, Mark J. (2016). NK cells and cancer immunoediting. Natural killer cells. (pp. 115-145) edited by Eric Vivier, James Di Santo and Alessandro Moretta. [Cham], Switzerland: Springer. doi: 10.1007/82_2015_446

Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis

Tu, Cui, Buckle, Irina, Leal Rojas, Ingrid, Rossi, Gustavo Rodrigues, Sester, David P, Moore, Andrew S, Radford, Kristen, Guillerey, Camille and Souza‐Fonseca‐Guimaraes, Fernando (2024). Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis. Clinical & Translational Immunology, 13 (3) e1501. doi: 10.1002/cti2.1501

Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells

Liam, O'Brien, Carina, Walpole, Ingrid, Leal-Rojas, Svetlana, Shatunova, Andrew, Moore, Winkler, Ingrid G, Camille, Guillerey and Radford, Kristen J (2023). Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells. Experimental Hematology, 130 104134, 104134. doi: 10.1016/j.exphem.2023.11.008

TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

Pichler, Andrea C., Carrié, Nadège, Cuisinier, Marine, Ghazali, Samira, Voisin, Alison, Axisa, Pierre-Paul, Tosolini, Marie, Mazzotti, Céline, Golec, Dominic P., Maheo, Sabrina, do Souto, Laura, Ekren, Rüçhan, Blanquart, Eve, Lemaitre, Lea, Feliu, Virginie, Joubert, Marie-Véronique, Cannons, Jennifer L., Guillerey, Camille, Avet-Loiseau, Hervé, Watts, Tania H., Salomon, Benoit L., Joffre, Olivier, Grinberg-Bleyer, Yenkel, Schwarzberg, Pamela L., Lucca, Liliana E. and Martinet, Ludovic (2023). TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation. Immunity, 56 (7), 1631-1648.e10. doi: 10.1016/j.immuni.2023.06.007

High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood

Buckle, Irina, Johnson, Anthony, Rojas, Ingrid Leal, Weinert, Vicky, Sester, David P., Radford, Kristen and Guillerey, Camille (2023). High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood. European Journal of Immunology, 53 (6) 2250118, 1-13. doi: 10.1002/eji.202250118

Inhibitory receptors and immune checkpoints regulating natural killer cell responses to cancer

Buckle, Irina and Guillerey, Camille (2021). Inhibitory receptors and immune checkpoints regulating natural killer cell responses to cancer. Cancers, 13 (17) 4263. doi: 10.3390/cancers13174263

Eomes-dependent loss of the co-activating receptor CD226 restrains CD8+ T cell anti-tumor functions and limits the efficacy of cancer immunotherapy

Weulersse, Marianne, Asrir, Assia, Pichler, Andrea C., Lemaitre, Lea, Braun, Matthias, Carrié, Nadège, Joubert, Marie-Véronique, Le Moine, Marie, Do Souto, Laura, Gaud, Guillaume, Das, Indrajit, Brauns, Elisa, Scarlata, Clara M., Morandi, Elena, Sundarrajan, Ashmitha, Cuisinier, Marine, Buisson, Laure, Maheo, Sabrina, Kassem, Sahar, Agesta, Arantxa, Pérès, Michaël, Verhoeyen, Els, Martinez, Alejandra, Mazieres, Julien, Dupré, Loïc, Gossye, Thomas, Pancaldi, Vera, Guillerey, Camille, Ayyoub, Maha ... Martinet, Ludovic (2020). Eomes-dependent loss of the co-activating receptor CD226 restrains CD8+ T cell anti-tumor functions and limits the efficacy of cancer immunotherapy. Immunity, 53 (4), 824-839.e10. doi: 10.1016/j.immuni.2020.09.006

Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma

Guillerey, Camille, Stannard, Kimberley, Chen, Jason, Krumeich, Sophie, Miles, Kim, Nakamura, Kyohei, Smith, Jessica, Yu, Yuan, Ng, Susanna, Harjunpää, Heidi, Teng, Michele W. L., Engwerda, Christian, Belz, Gabrielle T. and Smyth, Mark J. (2020). Systemic administration of IL‐33 induces a population of circulating KLRG1 hi type 2 innate lymphoid cells and inhibits type 1 innate immunity against multiple myeloma. Immunology and Cell Biology, 99 (1) imcb.12390, 65-83. doi: 10.1111/imcb.12390

TIGIT as an emerging immune checkpoint

Harjunpaeae, H. and Guillerey, C. (2019). TIGIT as an emerging immune checkpoint. Clinical and Experimental Immunology, 200 (2) cei.13407, 108-119. doi: 10.1111/cei.13407

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

Guillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C., Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I., Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele W.L., Bergsagel, P. Leif, Chesi, Marta, Hill, Geoffrey R., Martinet, Ludovic and Smyth, Mark J. (2019). Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. JCI Insight, 4 (14) :e125932. doi: 10.1172/jci.insight.125932

Can Dendritic Cell vaccination prevent leukemia relapse?

O’Brien, Liam J., Guillerey, Camille and Radford, Kristen J. (2019). Can Dendritic Cell vaccination prevent leukemia relapse?. Cancers, 11 (6) 875, 875. doi: 10.3390/cancers11060875

Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions

Stannard, Kimberley A., Lemoine, Sébastien, Waterhouse, Nigel J., Vari, Frank, Chatenoud, Lucienne, Gandhi, Maher K., Martinet, Ludovic, Smyth, Mark J. and Guillerey, Camille (2019). Human peripheral blood DNAM-1neg NK cells are a terminally differentiated subset with limited effector functions. Blood Advances, 3 (11), 1681-1694. doi: 10.1182/bloodadvances.2018030676

Roles of cytotoxic and helper innate lymphoid cells in cancer

Guillerey, Camille (2018). Roles of cytotoxic and helper innate lymphoid cells in cancer. Mammalian Genome, 29 (11-12), 777-789. doi: 10.1007/s00335-018-9781-4

Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade

Minnie, Simone A., Kuns, Rachel D., Gartlan, Kate H., Zhang, Ping, Wilkinson, Andrew N., Samson, Luke, Guillerey, Camille, Engwerda, Christian, MacDonald, Kelli P. A., Smyth, Mark J., Markey, Kate A., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Myeloma escape after stem cell transplantation is a consequence of t-cell exhaustion and is prevented by tigit blockade. Blood, 132 (16), 1675-1688. doi: 10.1182/blood-2018-01-825240

Bone marrow transplantation generates T cell–dependent control of myeloma in mice

Vuckovic, Slavica, Minnie, Simone A., Smith, David, Gartlan, Kate H., Watkins, Thomas S., Markey, Kate A., Mukhopadhyay, Pamela, Guillerey, Camille, Kuns, Rachel D., Locke, Kelly R., Pritchard, Antonia L., Johansson, Peter A., Varelias, Antiopi, Zhang, Ping, Huntington, Nicholas D., Waddell, Nicola, Chesi, Marta, Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Bone marrow transplantation generates T cell–dependent control of myeloma in mice. Journal of Clinical Investigation, 129 (1) CI98888, 106-121. doi: 10.1172/jci98888

TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma

Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W. L., Nakamura, Kyohei, Martinet, Ludovic and Smyth, Mark J. (2018). TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma. Blood, 132 (16), blood-2018. doi: 10.1182/blood-2018-01-825265

Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells

Oberkampf, Marine, Guillerey, Camille, Mouriès, Juliette, Rosenbaum, Pierre, Fayolle, Catherine, Bobard, Alexandre, Savina, Ariel, Ogier-Denis, Eric, Enninga, Jost, Amigorena, Sebastian, Leclerc, Claude and Dadaglio, Gilles (2018). Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nature Communications, 9 (1) 2241, 2241. doi: 10.1038/s41467-018-04686-8

Tumor-derived TGFb alters the ability of plasmacytoid dendritic cells to respond to innate immune signaling

Terra, Mariana, Oberkampf, Marine, Fayolle, Catherine, Rosenbaum, Pierre, Guillerey, Camille, Dadaglio, Gilles and Leclerc, Claude (2018). Tumor-derived TGFb alters the ability of plasmacytoid dendritic cells to respond to innate immune signaling. Cancer Research, 78 (11), 3014-3026. doi: 10.1158/0008-5472.CAN-17-2719

Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium

Minnie, Simone, Vuckovic, Slavica, Smith, David, Gartlan, Kate H., Watkins, Thomas S., Kuns, Rachel D., Guillerey, Camille, Chesi, Marta, Markey, Kate A., Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium. The Journal of Immunology, 200 (1_Supplement), 55.19-55.19. doi: 10.4049/jimmunol.200.supp.55.19

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

Harjunpää, Heidi, Blake, Stephen J., Ahern, Elizabeth, Allen, Stacey, Liu, Jing, Yan, Juming, Lutzky, Viviana, Takeda, Kazuyoshi, Aguilera, Amy Roman, Guillerey, Camille, Mittal, Deepak, Li, Xian Yang, Dougall, William C., Smyth, Mark J. and Teng, Michele W. L. (2018). Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis. OncoImmunology, 7 (7) e1445949, e1445949. doi: 10.1080/2162402X.2018.1445949

Dysregulated IL-18 Is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment

Nakamura, Kyohei, Kassem, Sahar, Cleynen, Alice, Chrétien, Marie-Lorraine, Guillerey, Camille, Putz, Eva Maria, Bald, Tobias, Förster, Irmgard, Vuckovic, Slavica, Hill, Geoffrey R, Masters, Seth L, Chesi, Marta, Bergsagel, P Leif, Avet-Loiseau, Hervé, Martinet, Ludovic and Smyth, Mark J. (2018). Dysregulated IL-18 Is a key driver of immunosuppression and a possible therapeutic target in the multiple myeloma microenvironment. Cancer Cell, 33 (4), 634-648. doi: 10.1016/j.ccell.2018.02.007

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection

Ng, Susanna S., Souza-Fonseca-Guimaraes, Fernando, Rivera, Fabian de Labastida, Amante, Fiona H., Kumar, Rajiv, Gao, Yulong, Sheel, Meru, Beattie, Lynette, de Oca, Marcela Montes, Guillerey, Camille, Edwards, Chelsea L., Faleiro, Rebecca J., Frame, Teija, Bunn, Patrick T., Vivier, Eric, Godfrey, Dale I., Pellicci, Daniel G., Lopez, J. Alejandro, Andrews, Katherine T., Huntington, Nicholas D., Smyth, Mark J., McCarthy, James and Engwerda, Christian R. (2018). Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection. Clinical and Translational Immunology, 7 (1) e1003, e1003. doi: 10.1002/cti2.1003

Cytokine-driven role of Srebps in killer cell metabolism

Guillerey, Camille and Smyth, Mark J. (2017). Cytokine-driven role of Srebps in killer cell metabolism. Nature Immunology, 18 (11), 1183-1184. doi: 10.1038/ni.3855

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

Putz, Eva M., Guillerey, Camille, Kos, Kevin, Stannard, Kimberley, Miles, Kim, Delconte, Rebecca B, Takeda, Kazuyoshi, Nicholson, Sandra E., Huntington, Nicholas D. and Smyth, Mark J. (2017). Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis. OncoImmunology, 6 (2) e1267892, e1267892. doi: 10.1080/2162402X.2016.1267892

Targeting natural killer cells in cancer immunotherapy

Guillerey, Camille, Huntington, Nicholas D. and Smyth, Mark J. (2016). Targeting natural killer cells in cancer immunotherapy. Nature Immunology, 17 (9), 1025-1036. doi: 10.1038/ni.3518

Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies

Guillerey, Camille, Nakamura, Kyohei, Vuckovic, Slavica, Hill, Geoffrey R. and Smyth, Mark J. (2016). Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies. Cellular and Molecular Life Sciences, 73 (8), 1569-1589. doi: 10.1007/s00018-016-2135-z

Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Marta, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (7), 2904-2904. doi: 10.1172/JCI82646

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Martha, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015). Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 (5), 2077-2089. doi: 10.1172/JCI77181

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, Ludovic, FerrariDeAndrade, Lucas, Guillerey, Camille, Lee, Jason S, Liu, Jing, Souza-Fonseca-Guimaraes, Fernando, Hutchinson, Dana S, Kolesnik, Tatiana B, Nicholson, Sandra E, Huntington, Nicholas D and Smyth, Mark J (2015). DNAM-1 expression marks an alternative program of NK cell maturation. Cell Reports, 11 (1), 85-97. doi: 10.1016/j.celrep.2015.03.006

Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis

Guillerey, Camille, Chow, Melvyn T., Miles, Kim, Olver, Stuart, Sceneay, Jaclyn, Takeda, Kazuyoshi, Möller, Andreas and Smyth, Mark J. (2015). Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis. Oncoimmunology, 4 (9), 1-11. doi: 10.1080/2162402X.2015.1027468

Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice

Guillerey, Camille, Mouries̀, Juliette, Polo, Giulia, Doyen, Noelle, Law, Helen K. W., Chan, Susan, Kastner, Philippe, Leclerc, Claude and Dadaglio, Gilles (2012). Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Blood, 120 (1), 90-99. doi: 10.1182/blood-2012-02-410936

FoxO3 Regulates Neural Stem Cell Homeostasis

Renault, Valérie M., Rafalski, Victoria A., Morgan, Alex A., Salih, Dervis A.M., Brett, Jamie O., Webb, Ashley E., Villeda, Saul A., Thekkat, Pramod U., Guillerey, Camille, Denko, Nicholas C., Palmer, Theo D., Butte, Atul J. and Brunet, Anne (2009). FoxO3 Regulates Neural Stem Cell Homeostasis. Cell Stem Cell, 5 (5), 527-539. doi: 10.1016/j.stem.2009.09.014

Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium

Minnie, Simone, Vuckovic, Slavica, Smith, David, Gartlan, Kate H., Watkins, Thomas S., Kuns, Rachel D., Guillerey, Camille, Chesi, Marta, Markey, Kate A., Miles, John J., Smyth, Mark J. and Hill, Geoffrey R. (2018). Syngeneic stem cell transplantation generates antigen-specific T cells that maintain myeloma-immune equilibrium. Immunology Meeting, Austin, TX, United States, 4-8 May, 2018. Rockville, MD, United States: American Association of Immunologists.

Therapeutic potential anti-CD137 mAbs in multiple myeloma

Guillerey, C., de Andrade, L. F., Miles, K., Vuckovic, S., Chesi, M., Bergsagel, L. P., Geoffrey, R. H., Martinet, L. and Smyth, M. J. (2016). Therapeutic potential anti-CD137 mAbs in multiple myeloma. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH.