The University of Queensland

Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG

Yan, Shiyu, Rolfe, Barbara E., Zhang, Bing, Mohammed, Yousuf H., Gu, Wenyi and Xu, Zhi P. (2014). Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG. Biomaterials, 35 (35), 9508-9516. doi: 10.1016/j.biomaterials.2014.07.055

Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways

Chen, Jiezhong, Shao, Renfu, Li, Li, Xu, Zhi Ping and Gu, Wenyi (2014). Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways. International Journal of Nanomedicine, 9 (1), 3403-3411. doi: 10.2147/IJN.S61633

Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Niu, Yuting, Yu, Meihua, Hartono, Sandy B., Yang, Jie, Xu, Hongyi, Zhang, Hongwei, Zhang, Jun, Zou, Jin, Dexter, Annette, Gu, Wenyi and Yu, Chengzhong (2013). Nanoparticles mimicking viral surface topography for enhanced cellular delivery. Advanced Materials, 25 (43), 6233-6237. doi: 10.1002/adma.201302737

An influenza virus-inspired polymer system for the timed release of siRNA

Truong, Nghia P., Gu, Wenyi, Prasadam, Indira, Jia, Zhongfan, Crawford, Ross, Xiao, Yin and Monteiro, Michael J. (2013). An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications, 4 (1) 1902, 1902. doi: 10.1038/ncomms2905

Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery

Hartono, Sandy B., Gu, Wenyi, Kleitz, Freddy, Liu, Jian, He, Lizhong, Middelberg, Anton P. J., Yu, Chengzhong, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012). Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. ACS Nano, 6 (3), 2104-2117. doi: 10.1021/nn2039643

Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel (2009). Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 (20), 8314-8319. doi: 10.1073/pnas.0812085106

Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation

Gu, Wenyi, Ding, Jianmin M., Wang, Xiao, de Kluyver, Rachel L., Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2007). Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Research, 35 (14), 4820-4832. doi: 10.1093/nar/gkm496

Silencing of E6/E7 expression in cervical cancer stem-like cells

Gu, Wenyi, McMillan, Nigel and Yu, Chengzhong (2015). Silencing of E6/E7 expression in cervical cancer stem-like cells. Cervical cancer: methods and protocols. (pp. 173-182) edited by Daniel Keppler and Athena W. Lin. New York, NY United States: Springer. doi: 10.1007/978-1-4939-2013-6_12

Mesenchymal stem cells and nano-structured surfaces

Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi (2013). Mesenchymal stem cells and nano-structured surfaces. Stem Cell Nanotechnology: Methods and Protocols. (pp. 133-148) edited by Turksen, K. New York, NY, United States: Humana Press. doi: 10.1007/7651_2013_30

siRNA and shRNA as anti-cancer agents in a cervical cancer model

Gu, W., Putral, L. and McMillan, N. A. J. (2008). siRNA and shRNA as anti-cancer agents in a cervical cancer model. RNAi : design and application. (pp. 159-172) edited by J. M. Walker. Totowa, N.J., U.S.A.: Humana Press, Inc..

Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy

Li, Fangling, Cao, Dongdong, Gu, Wenyi, Li, Dongmei, Liu, Zhiyong and Cui, Lin (2024). Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy. International Journal of Molecular Sciences, 25 (5) 2932, 2932. doi: 10.3390/ijms25052932

Effects of seipin on mouse mesenchymal stem cell Osteo-Adipogenic Balance

Li, Zeying, Jin, Shan, Xu, Tong, Chen, Hongzhi, Cai, Wenping, Du, Jin, Jin, Qiu, Zhuang, Sihui, Qi, Yan, Gu, Wenyi and Pang, Lijuan (2024). Effects of seipin on mouse mesenchymal stem cell Osteo-Adipogenic Balance. Stem Cells and Development (ja), 177-188. doi: 10.1089/scd.2023.0107

An essential role of c-Fos in Notch1-mediated promotion of proliferation of KSHV-Infected SH-SY5Y Cells

Xu, Huiling, Huang, Jinghong, Yao, Lixia, Gu, Wenyi, Ruzi, Aynisahan, Ding, Yufei, Li, Ying, Liang, Weihua, Jiang, Jinfang, Pan, Zemin, Cao, Dongdong, Zhou, Naiming, Li, Dongmei and Zhang, Jinli (2024). An essential role of c-Fos in Notch1-mediated promotion of proliferation of KSHV-Infected SH-SY5Y Cells. Current Molecular Pharmacology, 17 e18761429264583, 1-13. doi: 10.2174/0118761429264583231106104202

Targeted delivery of miR-34a-5p by phenylborate-coupled polyethylenimide nanocarriers for anti-KSHV treatment

Li, Fangling, Cao, Dongdong, Yao, Lixia, Gu, Wenyi, Liu, Zhiyong, Li, Dongmei and Cui, Lin (2024). Targeted delivery of miR-34a-5p by phenylborate-coupled polyethylenimide nanocarriers for anti-KSHV treatment. Frontiers in Bioengineering and Biotechnology, 11 ARTN 1343956, 1343956. doi: 10.3389/fbioe.2023.1343956

Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection

Tao, Ya, Xu, Lei, Liu, Xiaopan, Wang, Peijia, Wei, Simin, Huang, Yinmo, Gu, Wenyi, Bo, Ruonan, Liu, Mingjiang, Yu, Jie and Li, Jingui (2024). Chitosan-coated artesunate protects against ulcerative colitis via STAT6-mediated macrophage M2 polarization and intestinal barrier protection. International Journal of Biological Macromolecules, 254 (Part 1) 127680, 127680. doi: 10.1016/j.ijbiomac.2023.127680

M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma

Yang, Kaige, Xie, Yufang, Xue, Lele, Li, Fanping, Luo, Chenghua, Liang, Weihua, Zhang, Haijun, Li, Ya, Ren, Yilin, Zhao, Mengmeng, Wang, Weinan, Liu, Jia, Shen, Xihua, Zhou, Wenhu, Fei, Jing, Chen, Weigang, Gu, Wenyi, Wang, Lianghai, Li, Feng and Hu, Jianming (2023). M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma. Journal of Translational Medicine, 21 (1) 26, 26. doi: 10.1186/s12967-022-03863-0

17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells

Li, Hongzhuo, Gu, Wenyi, Jeffery, Penny and Chen, Chen (2023). 17‐β‐estradiol reduces surface PD‐L1 expression in estrogen receptor‐positive breast cancer but not type 1 endometrial cancer cells. Clinical and Translational Medicine, 13 (7) e1330, e1330. doi: 10.1002/ctm2.1330

Delivery of miR-34a-5p by folic acid-modified β-cyclodextrin-grafted polyethylenimine copolymer nanocarriers to resist KSHV

Li, Fangling, Cao, Dongdong, Gu, Wenyi, Cui, Lin, Qiu, Zhongpeng, Liu, Zhiyong, Li, Dongmei and Guo, Xuhong (2023). Delivery of miR-34a-5p by folic acid-modified β-cyclodextrin-grafted polyethylenimine copolymer nanocarriers to resist KSHV. ACS Applied Nano Materials, 6 (12), 10826-10836. doi: 10.1021/acsanm.3c02162

Bioinformatics-based identification of CircRNA-MicroRNA-mRNA network for calcific aortic valve disease

Song, Linghong, Wang, Yubing, Feng, Yufei, Peng, Hao, Wang, Chengyan, Duan, Juncang, Liu, Kejian, Shen, Xihua, Gu, Wenyi, Qi, Yan, Jin, Shan and Pang, Lijuan (2023). Bioinformatics-based identification of CircRNA-MicroRNA-mRNA network for calcific aortic valve disease. Genetics Research, 2023 8194338, 1-12. doi: 10.1155/2023/8194338

Parthenolide inhibits proliferation of cells infected with Kaposi’s sarcoma-associated herpesvirus by suppression of the NF-κB signaling pathway

Li, Ying, Xu, Huiling, Tan, Xiaohua, Cui, Qinghua, Gu, Wenyi, Pan, Zemin, Yang, Lei, Wu, Shuyuan, Wang, Xiaolu and Li, Dongmei (2023). Parthenolide inhibits proliferation of cells infected with Kaposi’s sarcoma-associated herpesvirus by suppression of the NF-κB signaling pathway. Archives of Virology, 168 (2) 39, 39. doi: 10.1007/s00705-022-05626-0

RGD-coated polymer nanoworms for enriching cancer stem cells

Gu, Yushu, Bobrin, Valentin, Zhang, Dayong, Sun, Bing, Ng, Chun Ki, Chen, Sung-Po R., Gu, Wenyi and Monteiro, Michael J. (2022). RGD-coated polymer nanoworms for enriching cancer stem cells. Cancers, 15 (1) 234, 234. doi: 10.3390/cancers15010234

Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

Qin, Binyu, Zeng, Zhili, Xu, Jianliang, Shangwen, Jing, Ye, Zeng Jie, Wang, Shutang, Wu, Yanheng, Peng, Gongfeng, Wang, Qi, Gu, Wenyi and Tang, Ying (2022). Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin. BMC Cancer, 22 (1) 671, 1-17. doi: 10.1186/s12885-022-09684-0

Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

Qi, Yan, Zou, Hong, Zhao, XiaoHui, Kapeleris, Joanna, Monteiro, Michael, Li, Feng, Xu, Zhi Ping, Deng, Yizhen, Wu, Yanheng, Tang, Ying and Gu, Wenyi (2022). Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway. Frontiers in Pharmacology, 13 996053, 1-16. doi: 10.3389/fphar.2022.996053

Integrated microarray for identifying the hub mRNAs and constructed miRNA-mRNA network in coronary in-stent restenosis

Song, Linghong, Feng, Yufei, Tian, Feng, Liu, Xiaoang, Jin, Shan, Wang, Chengyan, Tang, Wuyue, Duan, Juncang, Guo, Na, Shen, Xihua, Hu, Jianming, Zou, Hong, Gu, Wenyi, Liu, Kejian and Pang, Lijuan (2022). Integrated microarray for identifying the hub mRNAs and constructed miRNA-mRNA network in coronary in-stent restenosis. Physiological Genomics, 54 (10), 371-379. doi: 10.1152/physiolgenomics.00089.2021

PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth

Movahedi, Fatemeh, Liu, Jie, Sun, Bing, Cao, Pei, Sun, Luyao, Howard, Christopher, Gu, Wenyi and Xu, Zhi Ping (2022). PD-L1-targeted co-delivery of two chemotherapeutics for efficient suppression of skin cancer growth. Pharmaceutics, 14 (7) 1488, 1488. doi: 10.3390/pharmaceutics14071488

miR-34a-5p inhibits the malignant progression of KSHV-infected SH-SY5Y cells by targeting c-fos

Wu, Shuyuan, Wu, Zhaofu, Xu, Huiling, Zhang, Jinli, Gu, Wenyi, Tan, Xiaohua, Pan, Zemin, Cao, Dongdong, Li, Dongmei, Yang, Lei, Li, Dongmei and Pan, Yuanming (2022). miR-34a-5p inhibits the malignant progression of KSHV-infected SH-SY5Y cells by targeting c-fos. PeerJ, 10 e13233, e13233. doi: 10.7717/peerj.13233

Prognostic and therapeutic TILs of cervical cancer—current advances and future perspectives

Tang, Ying, Zhang, Anne X. J., Chen, Guangyu, Wu, Yanheng and Gu, Wenyi (2021). Prognostic and therapeutic TILs of cervical cancer—current advances and future perspectives. Molecular Therapy - Oncolytics, 22, 410-430. doi: 10.1016/j.omto.2021.07.006

Water-borne nanocoating for rapid inactivation of SARS-CoV-2 and other viruses

Bobrin, Valentin A., Chen, Sung-Po, Grandes Reyes, Carlos Fitzgerald, Sun, Bing, Ng, Chun Ki, Kim, Youry, Purcell, Damian, Jia, Zhongfan, Gu, Wenyi, Armstrong, Jason W., McAuley, Julie and Monteiro, Michael J. (2021). Water-borne nanocoating for rapid inactivation of SARS-CoV-2 and other viruses. ACS Nano, 15 (9), 14915-14927. doi: 10.1021/acsnano.1c05075

ATP stabilised and sensitised calcium phosphate nanoparticles as effective adjuvants for a DNA vaccine against cancer

Sun, Bing, Zhao, Xiaohui, Gu, Wenxi, Cao, Pei, Movahedi, Fatemeh, Wu, Yanheng, Xu, Zhi Ping and Gu, Wenyi (2021). ATP stabilised and sensitised calcium phosphate nanoparticles as effective adjuvants for a DNA vaccine against cancer. Journal of Materials Chemistry B, 9 (36), 7435-7446. doi: 10.1039/d1tb01408k

Mechanisms of cancer stem cell senescence: current understanding and future perspectives

Zhang, Da‐yong, Monteiro, Michael J., Liu, Jun‐Ping and Gu, Wen‐yi (2021). Mechanisms of cancer stem cell senescence: current understanding and future perspectives. Clinical and Experimental Pharmacology and Physiology, 48 (9) 1440-1681.13528, 1185-1202. doi: 10.1111/1440-1681.13528

Encapsulating anti-parasite benzimidazole drugs into lipid-coated calcium phosphate nanoparticles to efficiently induce skin cancer cell apoptosis

Movahedi, Fatemeh, Gu, Wenyi, Soares, Christiane Pienna and Xu, Zhi Ping (2021). Encapsulating anti-parasite benzimidazole drugs into lipid-coated calcium phosphate nanoparticles to efficiently induce skin cancer cell apoptosis. Frontiers in Nanotechnology, 3 693837. doi: 10.3389/fnano.2021.693837

Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: a meta-analysis

Yuan, Xin, Zhang, An Zhi, Ren, Yi Lin, Wang, Xue Li, Jiang, Chen Hao, Yang, Lan, Liu, Chun Xia, Liang, Wei Hua, Pang, Li Juan, Gu, Wen Yi, Li, Feng and Hu, Jian Ming (2021). Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer: a meta-analysis. Medicine, 100 (13) e24519, 1-13. doi: 10.1097/MD.0000000000024519

Mannose-functionalized biodegradable nanoparticles efficiently deliver DNA vaccine and promote anti-tumor immunity

Sun, Bing, Zhao, Xiaohui, Wu, Yanheng, Cao, Pei, Movahedi, Fatemeh, Liu, Jie, Wang, Jingjing, Xu, Zhi Ping and Gu, Wenyi (2021). Mannose-functionalized biodegradable nanoparticles efficiently deliver DNA vaccine and promote anti-tumor immunity. ACS Applied Materials and Interfaces, 13 (12), 14015-14027. doi: 10.1021/acsami.1c01401

Calcium-bisphosphonate nanoparticle platform as a prolonged nanodrug and bone-targeted delivery system for bone diseases and cancers

Lin, Yanling, Villacanas, Maria G., Zou, Hong, Liu, Hangrui, Carcedo, Ines G., Wu, Yilun, Sun, Bing, Wu, Xiaoxin, Prasadam, Indira, Monteiro, Michael J., Li, Li, Xu, Zhi Ping and Gu, Wenyi (2021). Calcium-bisphosphonate nanoparticle platform as a prolonged nanodrug and bone-targeted delivery system for bone diseases and cancers. ACS Applied Bio Materials, 4 (3) acsabm.0c01455, 2490-2501. doi: 10.1021/acsabm.0c01455

Synergistic inhibition of drug-resistant colon cancer growth with PI3K/mTOR dual inhibitor BEZ235 and nano-emulsioned paclitaxel via reducing multidrug resistance and promoting apoptosis

Hu, Yali, Zhang, Kunpeng, Zhu, Xingyao, Zheng, Xiuyan, Wang, Chao, Niu, Xiao, Jiang, Teng, Ji, Xinhua, Zhao, Weilin, Pang, Lijuan, Qi, Yan, Li, Feng, Li, Li, Xu, Zhiping, Gu, Wenyi and Zou, Hong (2021). Synergistic inhibition of drug-resistant colon cancer growth with PI3K/mTOR dual inhibitor BEZ235 and nano-emulsioned paclitaxel via reducing multidrug resistance and promoting apoptosis. International Journal of Nanomedicine, 16, 2173-2186. doi: 10.2147/IJN.S290731

Short-term exposure to ZnO/MCB persistent free radical particles causes mouse lung lesions via inflammatory reactions and apoptosis pathways

Zhang, Xing, Gu, Wenyi, Ma, Zhongliang, Liu, Yun, Ru, Hongbo, Zhou, Jizhi, Zang, Yi, Xu, ZhiPing and Qian, Guangren (2020). Short-term exposure to ZnO/MCB persistent free radical particles causes mouse lung lesions via inflammatory reactions and apoptosis pathways. Environmental Pollution, 261 114039, 114039. doi: 10.1016/j.envpol.2020.114039

Nanostructuring a widely used antiworm drug into the lipid-coated calcium phosphate matrix for enhanced skin tumor treatment

Movahedi, Fatemeh, Wu, Yilun, Gu, Wenyi and Xu, Zhi Ping (2020). Nanostructuring a widely used antiworm drug into the lipid-coated calcium phosphate matrix for enhanced skin tumor treatment. ACS Applied Bio Materials, 3 (7), 4230-4238. doi: 10.1021/acsabm.0c00313

Therapeutic delivery of polymeric tadpole nanostructures with high selectivity to triple negative breast cancer cells

Bobrin, Valentin A., Lin, Yanling, He, Jianwei, Qi, Yan, Gu, Wenyi and Monteiro, Michael J. (2020). Therapeutic delivery of polymeric tadpole nanostructures with high selectivity to triple negative breast cancer cells. Biomacromolecules, 21 (11) acs.biomac.0c00302, 4457-4468. doi: 10.1021/acs.biomac.0c00302

Enhanced prevention of breast tumor metastasis by nanoparticle‐delivered vitamin E in combination with interferon‐gamma

Wu, Yilun, Liu, Jianping, Movahedi, Fatemeh, Gu, Wenyi, Xu, Tiefeng and Xu, Zhi Ping (2020). Enhanced prevention of breast tumor metastasis by nanoparticle‐delivered vitamin E in combination with interferon‐gamma. Advanced Healthcare Materials, 9 (6) 1901706, 1901706. doi: 10.1002/adhm.201901706

Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma

Jiang, Chen Hao, Yuan, Xin, Li, Jiang Fen, Xie, Yu Fang, Zhang, An Zhi, Wang, Xue Li, Yang, Lan, Liu, Chun Xia, Liang, Wei Hua, Pang, Li Juan, Zou, Hong, Cui, Xiao Bin, Shen, Xi Hua, Qi, Yan, Jiang, Jin Fang, Gu, Wen Yi, Li, Feng and Hu, Jian Ming (2020). Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma. Journal of Translational Medicine, 18 (1) 40, 40. doi: 10.1186/s12967-020-02229-8

Bisphosphonate stabilized calcium phosphate nanoparticles for effective delivery of plasmid DNA to macrophages

Sun, Bing, Gillard, Marianne, Wu, Yanheng, Wu, Peihong, Xu, Zhi Ping and Gu, Wenyi (2020). Bisphosphonate stabilized calcium phosphate nanoparticles for effective delivery of plasmid DNA to macrophages. ACS Applied Bio Materials, 3 (2) acsabm.9b00994, 986-996. doi: 10.1021/acsabm.9b00994

Cancer stemness contributes to cluster formation of colon cancer cells and high metastatic potentials

Kapeleris, Joanna, Zou, Hong, Qi, Yan, Gu, Yushu, Li, Jingyun, Schoning, Jennifer, Monteiro, Michael J. and Gu, Wenyi (2020). Cancer stemness contributes to cluster formation of colon cancer cells and high metastatic potentials. Clinical and Experimental Pharmacology and Physiology, 47 (5) 1440-1681.13247, 838-847. doi: 10.1111/1440-1681.13247

Prognostic role of upregulated P300 expression in human cancers: a clinical study of synovial sarcoma and a meta-analysis

Liu, Zihan, He, Yonglai, Lian, Xiaojuan, Zou, Hong, Huang, Yalan, Wang, Ning, Hu, Jianming, Cui, Xiaobin, Zhao, Jin, Zhang, Wenjie, Gu, Wenyi, Pang, Lijuan and Qi, Yan (2019). Prognostic role of upregulated P300 expression in human cancers: a clinical study of synovial sarcoma and a meta-analysis. Experimental and Therapeutic Medicine, 18 (4), 3161-3171. doi: 10.3892/etm.2019.7906

PD-L1 distribution and perspective for cancer immunotherapy-blockade, knockdown, or inhibition

Wu, Yilun, Chen, Weiyu, Xu, Zhi Ping and Gu, Wenyi (2019). PD-L1 distribution and perspective for cancer immunotherapy-blockade, knockdown, or inhibition. Frontiers in Immunology, 10 (AUG) 2022, 2022. doi: 10.3389/fimmu.2019.02022

Membrane-tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinoma

Zheng, Yang, Wang, Zhao, Xiong, Xianbin, Zhong, Yi, Zhang, Wei, Dong, Yibo, Li, Jialiang, Zhu, Zaiou, Zhang, Wei, Wu, Heming, Gu, Wenyi, Wu, Yunong, Wang, Xiang and Song, Xiaomeng (2019). Membrane-tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinoma. Journal of Cellular Physiology, 234 (5) jcp.27022, 5940-5952. doi: 10.1002/jcp.27022

Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes

Wu, Yanheng, Gu, Wenyi, Li, Jiang, Chen, Chen and Xu, Zhi Ping (2019). Silencing PD-1 and PD-L1 with nanoparticle-delivered small interfering RNA increases cytotoxicity of tumor-infiltrating lymphocytes. Nanomedicine, 14 (8), 955-967. doi: 10.2217/nnm-2018-0237

Cervical cancer cell lines are sensitive to sub-erythemal UV exposure

Gu, Wenyi, Sun, Surong, Kahn, Andrew, Dacus, Dalton, Wendel, Sebastian O., McMillan, Nigel and Wallace, Nicholas A. (2019). Cervical cancer cell lines are sensitive to sub-erythemal UV exposure. Gene, 688, 44-53. doi: 10.1016/j.gene.2018.11.079

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells

Chen, Mingshui, Sharma, Aditi, Lin, Yanling, Wu, Yanheng, He, Qi, Gu, Yushu, Xu, Zhi Ping, Monteiro, Michael and Gu, Wenyi (2019). Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells. BMC Cancer, 19 (1) 153, 153. doi: 10.1186/s12885-019-5364-3

High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide

Li, Mengxue, Sultanbawa, Yasmina, Xu, Zhi Ping, Gu, Wenyi, Chen, Weiyu, Liu, Jianyong and Qian, Guangren (2019). High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide. Colloids and Surfaces B: Biointerfaces, 174, 435-442. doi: 10.1016/j.colsurfb.2018.11.035

Modifying layered double hydroxide nanoparticles for tumor imaging and therapy

Li, Li, Li, Bei, Gu, Wenyi and Xu, Zhi Ping (2019). Modifying layered double hydroxide nanoparticles for tumor imaging and therapy. Clays and Clay Minerals, 67 (1), 72-80. doi: 10.1007/s42860-019-0006-z

Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells

Gu, Wenyi, Wang, Lihui, Wu, Yanheng and Liu, Jun-Ping (2019). Undo the brake of tumour immune tolerance with antibodies, peptide mimetics and small molecule compounds targeting PD-1/PD-L1 checkpoint at different locations for acceleration of cytotoxic immunity to cancer cells. Clinical and Experimental Pharmacology and Physiology, 46 (2), 105-115. doi: 10.1111/1440-1681.13056

Enhancing PD-1 gene silence in T lymphocytes by comparing the delivery performance of two inorganic nanoparticle platforms

Wu, Yanheng, Gu, Wenyi, Li, Li, Chen, Chen and Xu, Zhi (2019). Enhancing PD-1 gene silence in T lymphocytes by comparing the delivery performance of two inorganic nanoparticle platforms. Nanomaterials, 9 (2) 159, 159. doi: 10.3390/nano9020159

Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platform

Wu, Yilun, Gu, Wenyi and Xu, Zhi Ping (2019). Enhanced combination cancer therapy using lipid-calcium carbonate/phosphate nanoparticles as a targeted delivery platform. Nanomedicine, 14 (1), 77-92. doi: 10.2217/nnm-2018-0252

Cervical Screening by Pap Test and Visual Inspection Enabling Same-Day Biopsy in Low-Resource, High-Risk Communities

Tao, Lin, Amanguli, A., Li, Feng, Wang, Ying Hong, Yang, Lan, Mohemaiti, Meiliguli, Zhao, Jin, Zou, Xiao Guang, Saimaiti, Abudukeyoumu, Abudu, Mirensha, Maimaiti, Mikairemu, Chen, Shi Yan, Abudukelimu, Ruxianguli, Maimaiti, Ayinuer, Li, Shu Gang, Zhang, Wei, Aizimu, Ayinuer, Yang, An Qiang, Wang, Ju, Pang, Li Juan, Cao, Yu Guang, Gu, Wen Yi and Zhang, Wen Jie (2018). Cervical Screening by Pap Test and Visual Inspection Enabling Same-Day Biopsy in Low-Resource, High-Risk Communities. Obstetrics and gynecology, 132 (6), 1421-1429. doi: 10.1097/AOG.0000000000002973

The pathways for layered double hydroxide nanoparticles to enhance antigen (cross)-presentation on immune cells as adjuvants for protein vaccines

Yan, Shiyu, Xu, Kewei, Li, Li, Gu, Wenyi, Rolfe, Barbara E. and Xu, Zhi P. (2018). The pathways for layered double hydroxide nanoparticles to enhance antigen (cross)-presentation on immune cells as adjuvants for protein vaccines. Frontiers in Pharmacology, 9 (SEP) 1060, 1060. doi: 10.3389/fphar.2018.01060

Biodistribution of PNIPAM-Coated Nanostructures Synthesized by the TDMT Method

Gu, Wenyi, Bobrin, Valentin A., Chen, Sung-Po R., Wang, Zhao, Schoning, Jennifer P., Gu, Yushu, Chen, Weiyu, Chen, Mingshui, Jia, Zhongfan and Monteiro, Michael J. (2018). Biodistribution of PNIPAM-Coated Nanostructures Synthesized by the TDMT Method. Biomacromolecules, 20 (2) acs.biomac.8b01196, 625-634. doi: 10.1021/acs.biomac.8b01196

Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcoma

Wang, Ning, Liu, Zi-Han, Zou, Hong, Pang, Li-Juan, Gu, Wen-Yi, Hu, Jian-Ming, Li, Dong-Mei, Zhao, Jin, Zhang, Jun, Liu, Chun-Xia, Zhang, Wen-Jie, Qi, Yan and Li, Feng (2018). Laser capture microdissection for detecting the expression of epithelial-mesenchymal transition-related genes in epithelial and spindle cells of paraffin-embedded formalin-fixed biphasic synovial sarcoma. Clinical and Experimental Pharmacology and Physiology, 45 (7), 675-682. doi: 10.1111/1440-1681.12936

Optimization of formulations consisting of layered double hydroxide nanoparticles and small interfering RNA for efficient knockdown of the target gene

Wu, Yanheng, Gu, Wenyi, Chen, Chen, Do, Son Trong and Xu, Zhi Ping (2018). Optimization of formulations consisting of layered double hydroxide nanoparticles and small interfering RNA for efficient knockdown of the target gene. ACS Omega, 3 (5), 4871-4877. doi: 10.1021/acsomega.8b00397

Knocking down insulin receptor in pancreatic beta cell lines with lentiviral-small hairpin RNA reduces glucose-stimulated insulin secretion via decreasing the gene expression of insulin, GLUT2 and Pdx1

Wang, Jie, Gu, Wenyi and Chen, Chen (2018). Knocking down insulin receptor in pancreatic beta cell lines with lentiviral-small hairpin RNA reduces glucose-stimulated insulin secretion via decreasing the gene expression of insulin, GLUT2 and Pdx1. International Journal of Molecular Sciences, 19 (4) 985, 985. doi: 10.3390/ijms19040985

A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

Zheng, Yang, Wang, Zhao, Ding, Xu, Zhang, Wei, Li, Gang, Liu, Laikui, Wu, Heming, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2018). A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma. Cancer Cell International, 18 (1) 6, 1-15. doi: 10.1186/s12935-017-0496-5

One-pot synthesis of raspberry-like mesoporous silica nanospheres

Liu, Tingting, Liu, Lihong, Gu, Wenyi, Liu, Jian and Liu, Shaomin (2018). One-pot synthesis of raspberry-like mesoporous silica nanospheres. Journal of Nanoscience and Nanotechnology, 18 (1), 401-406. doi: 10.1166/jnn.2018.14607

Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression

Li, Kelu, Ma, Hongmei, Zheng, Xiuyan, Hu, Yali, Wang, Yue, Zhang, Kunpeng, Chen, Jiahan, Qi, Yan, Jiang, Jinfang, Pang, Lijuan, Tao, Lin, Gu, Wenyi, Li, Feng and Zou, Hong (2018). Overexpression of Polo-like kinase1 (PLK1) in chondrosarcoma and its implications for cancer progression. International Journal of Clinical and Experimental Pathology, 11 (3), 1707-1711.

Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma

Zheng, Yang, Wang, Zhao, Ding, Xu, Dong, Yibo, Zhang, Wei, Zhang, Wei, Zhong, Yi, Gu, Wenyi, Wu, Yunong and Song, Xiaomeng (2017). Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma. Cell Proliferation, 51 (3) e12424, e12424. doi: 10.1111/cpr.12424

High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations

Yan, Shiyu, Gu, Wenyi, Zhang, Bing, Rolfe, Barbara E and Xu, Zhi Ping (2017). High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations. Dalton Transactions, 47 (9), 2956-2964. doi: 10.1039/c7dt03725b

Nanoformulations of albendazole as effective anticancer and antiparasite agents

Movahedi, Fatemeh, Li, Li, Gu, Wenyi and Xu, Zhi Ping (2017). Nanoformulations of albendazole as effective anticancer and antiparasite agents. Nanomedicine, 12 (20), 2555-2574. doi: 10.2217/nnm-2017-0102

Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery

Wu, Yilun, Gu, Wenyi, Tang, Jie and Xu, Zhi Ping (2017). Devising new lipid-coated calcium phosphate/carbonate hybrid nanoparticles for controlled release in endosomes for efficient gene delivery. Journal of Materials Chemistry B, 5 (34), 7194-7203. doi: 10.1039/c7tb01635b

Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells

Qi, Yan, Wang, Ning, He, Yonglai, Zhang, Jun, Zou, Hong, Zhang, Wenjie, Gu, Wenyi, Huang, Yalan, Lian, Xiaojuan, Hu, Jianming, Zhao, Jin, Cui, Xiaobin, Pang, Lijuan and Li, Feng (2017). Transforming growth factor-β1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells. PLoS One, 12 (8) e0182680, e0182680. doi: 10.1371/journal.pone.0182680

Novel insights into mitochondrial gene rearrangement in thrips (Insecta: Thysanoptera) from the grass thrips, Anaphothrips obscurus

Liu, Hangrui, Song, Fan, Gu, Wenyi, Feng, Jinian, Cai, Wanzhi and Shao, Renfu (2017). Novel insights into mitochondrial gene rearrangement in thrips (Insecta: Thysanoptera) from the grass thrips, Anaphothrips obscurus. Scientific Reports, 7 (1) 4284, 4284. doi: 10.1038/s41598-017-04617-5

Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy

Li, Li, Zhang, Run, Gu, Wenyi and Ping, Zhi (2017). Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 14 (7), 2355-2364. doi: 10.1016/j.nano.2017.06.006

Increased PD-L1 expression in breast and colon cancer stem cells

Wu, Yanheng, Chen, Mingshui, Wu, Peihong, Chen, Chen, Xu, Zhi Ping and Gu, Wenyi (2017). Increased PD-L1 expression in breast and colon cancer stem cells. Clinical and Experimental Pharmacology and Physiology, 44 (5), 602-604. doi: 10.1111/1440-1681.12732

Prognostic value of the MicroRNA-29 family in multiple human cancers: a meta-analysis and systematic review

Qi, Yan, Huang, Yalan, Pang, Lijuan, Gu, Wenyi, Wang, Ning, Hu, Jianming, Cui, Xiaobin, Zhang, Jun, Zhao, Jin, Liu, Chunxia, Zhang, Wenjie, Zou, Hong and Li, Feng (2017). Prognostic value of the MicroRNA-29 family in multiple human cancers: a meta-analysis and systematic review. Clinical and Experimental Pharmacology and Physiology, 44 (4), 441-454. doi: 10.1111/1440-1681.12726

Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α

Schoning, Jennifer Petra, Monteiro, Michael and Gu, Wenyi (2017). Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α. Clinical and Experimental Pharmacology & Physiology, 44 (2), 153-161. doi: 10.1111/1440-1681.12693

Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates

Singhania, Richa, Pavey, Sandra, Payne, Elizabeth, Gu, Wenyi, Clancy, Jennifer, Jubair, Luqman, Preiss, Thomas, Saunders, Nicholas and McMillan, Nigel A. J. (2016). Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859 (8), 1034-1042. doi: 10.1016/j.bbagrm.2016.06.005

Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis

Prasadam, Indira, Batra, Jyotsna, Perry, Samuel, Gu, Wenyi, Crawford, Ross and Xiao, Yin (2016). Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis. Calcified Tissue International, 99 (1), 43-55. doi: 10.1007/s00223-016-0125-7

Efficient drug delivery using SiO2-layered double hydroxide nanocomposites

Li, Li, Gu, Zi, Gu, Wenyi, Liu, Jian and Xu, Zhi Ping (2016). Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science, 470, 47-55. doi: 10.1016/j.jcis.2016.02.042

Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/ mTOR dual inhibitor BEZ235 through apoptosis

Zou, Hong, Li, Li, Garcia Carcedo, Ines, Xu, Zhi Ping, Monteiro, Michael and Gu, Wenyi (2016). Synergistic inhibition of colon cancer cell growth with nanoemulsion-loaded paclitaxel and PI3K/ mTOR dual inhibitor BEZ235 through apoptosis. International Journal of Nanomedicine, 11, 1947-1958. doi: 10.2147/IJN.S100744

Efficient and durable vaccine against Intimin β of Diarrheagenic E. Coli induced by clay nanoparticles

Chen, Weiyu, Zhang, Bing, Mahony, Timothy, Gu, Wenyi, Rolfe, Barbara and Xu, Zhi Ping (2016). Efficient and durable vaccine against Intimin β of Diarrheagenic E. Coli induced by clay nanoparticles. Small, 12 (12), 1627-1639. doi: 10.1002/smll.201503359

Direct synthesis of layered double hydroxide nanosheets for efficient siRNA delivery

Li, L., Gu, Z., Gu, W. Y. and Xu, Z. P. (2016). Direct synthesis of layered double hydroxide nanosheets for efficient siRNA delivery. RSC Advances, 6 (98), 95518-95526. doi: 10.1039/c6ra19225d

Size-dependent gene delivery of amine-modified silica nanoparticles

Yu, Meihua, Niu, Yuting, Zhang, Jun, Zhang, Hongwei, Yang, Yannan, Taran, Elena, Jambhrunkar, Siddharth, Gu, Wenyi, Thorn, Peter and Yu, Chengzhong (2015). Size-dependent gene delivery of amine-modified silica nanoparticles. Nano Research, 9 (2), 291-305. doi: 10.1007/s12274-015-0909-5

PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells

Chen, Jiezhong, Shao, Renfu, Li, Feng, Monteiro, Michael, Liu, Jun-Ping, Xu, Zhi Ping and Gu, Wenyi (2015). PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells. Clinical and Experimental Pharmacology and Physiology, 42 (12), 1317-1326. doi: 10.1111/1440-1681.12493

Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

Gu, Wenyi, Prasadam, Indira, Yu, Meihua, Zhang, Fengxia, Ling, Patrick, Xiao, Yin and Yu, Chengzhong (2015). Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway. BMC Cancer, 15 (1) 609, 1-11. doi: 10.1186/s12885-015-1614-1

Nanotechnology in the management of cervical cancer

Chen, Jiezhong, Gu, Wenyi, Yang, Lei, Chen, Chen, Shao, Renfu, Xu, Kewei and Xu, Zhi Ping (2015). Nanotechnology in the management of cervical cancer. Reviews in Medical Virology, 25 (S1), 72-83. doi: 10.1002/rmv.1825

Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery

Li, Li, Gu, Wenyi, Liu, Jian, Yan, Shiyu and Xu, Zhi Ping (2015). Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery. Nano Research, 8 (2), 682-694. doi: 10.1007/s12274-014-0552-6

Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG

Yan, Shiyu, Rolfe, Barbara E., Zhang, Bing, Mohammed, Yousuf H., Gu, Wenyi and Xu, Zhi P. (2014). Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG. Biomaterials, 35 (35), 9508-9516. doi: 10.1016/j.biomaterials.2014.07.055

Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways

Chen, Jiezhong, Shao, Renfu, Li, Li, Xu, Zhi Ping and Gu, Wenyi (2014). Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways. International Journal of Nanomedicine, 9 (1), 3403-3411. doi: 10.2147/IJN.S61633

PTEN hypermethylation profiles of Chinese Kazakh patients with esophageal squamous cell carcinoma

Pan, Q. F., Li, W. T., Dong, H. C., Chen, Y. Z., Yin, L., Liu, W., Wang, W. W., Liu, D., Li, S. G., Gu, W. Y., Chen, J. Z., Yang, L., Zhang, W. J. and Li, F. (2014). PTEN hypermethylation profiles of Chinese Kazakh patients with esophageal squamous cell carcinoma. Diseases of the Esophagus, 27 (4), 396-402. doi: 10.1111/dote.12106

ATP- binding cassette transporter A1 ( ABCA1) promotes arsenic tolerance in human cells by reducing cellular arsenic accumulation

Tan, Xiaohua, Yang, Li, Xian, Lingling, Huang, Jin, Di, Chunhong, Gu, Wenyi, Guo, Shuli and Yang, Lei (2014). ATP- binding cassette transporter A1 ( ABCA1) promotes arsenic tolerance in human cells by reducing cellular arsenic accumulation. Clinical and Experimental Pharmacology and Physiology, 41 (4), 287-294. doi: 10.1111/1440-1681.12219

Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu and Xu, Zhi P. (2014). Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. Biomaterials, 35 (10), 3331-3339. doi: 10.1016/j.biomaterials.2013.12.095

Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma

Cui, Xiaobin, Zhao, Zhimin, Liu, Dong, Guo, Tao, Li, Su, Hu, Jianming, Liu, Chunxia, Yang, Lan, Cao, Yuwen, Jiang, Jinfang, Liang, Weihua, Liu, Wei, Li, Shugang, Wang, Lianghai, Wang, Lidong, Gu, Wenyi, Wu, Chuanyue, Chen, Yunzhao and Li, Feng (2014). Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. Journal of Experimental and Clinical Cancer Research, 33 (1) 20. doi: 10.1186/1756-9966-33-20

Synthesis of multi-functional large pore mesoporous silica nanoparticles as gene carriers

Hartono, Sandy B., Yu, Meihua, Gu, Wenyi, Yang, Jie, Strounina, Ekaterina, Wang, Xiaolin, Qiao, Shizhang and Yu, Chengzhong (2014). Synthesis of multi-functional large pore mesoporous silica nanoparticles as gene carriers. Nanotechnology, 25 (5) 055701, 055701.1-055701.13. doi: 10.1088/0957-4484/25/5/055701

Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway

Chen, Zetao, Wu, Chengtie, Gu, Wenyi, Klein, Travis, Crawford, Ross and Xiao, Yin (2014). Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials, 35 (5), 1507-1518. doi: 10.1016/j.biomaterials.2013.11.014

Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Niu, Yuting, Yu, Meihua, Hartono, Sandy B., Yang, Jie, Xu, Hongyi, Zhang, Hongwei, Zhang, Jun, Zou, Jin, Dexter, Annette, Gu, Wenyi and Yu, Chengzhong (2013). Nanoparticles mimicking viral surface topography for enhanced cellular delivery. Advanced Materials, 25 (43), 6233-6237. doi: 10.1002/adma.201302737

Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population

Cui, Xiao-Bin, Chen, Yun-Zhao, Pang, Xue-lian, Liu, Wei, Hu, Jian-Ming, Li, Shu-Gang, Yang, Lan, Zhang, Wen-Jie, Liu, Chun-xia, Cao, Yu-wen, Jiang, Jin-Fang, Gu, Wen-Yi, Pang, James, Yang, Lei, Yuan, Xiang-Lin, Yu, Shi-Ying and Li, Feng (2013). Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. Gene, 530 (2), 315-322. doi: 10.1016/j.gene.2013.08.057

Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: Role of integrinβ1 and focal adhesion kinase signaling cues

Prasadam, Indira, Farnaghi, Saba, Feng, Jian Q., Gu, Wenyi, Perry, Samuel, Crawford, Ross and Xiao, Yin (2013). Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: Role of integrinβ1 and focal adhesion kinase signaling cues. Arthritis Research & Therapy, 15 (5). doi: 10.1186/ar4333

Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness

Chen, Yun-Zhao, Cui, Xiao-Bin, Hu, Jian-Ming, Zhang, Wen Jie, Li, Shu-Gang, Yang, Lan, Shen, Xi-Hua, Liu, Chun-Xia, Pan, Qing-Fang, Yu, Shi-Ying, Yuan, Xiang-Lin, Yang, Lei, Gu, Wen-Yi, Chen, Jie-Zhong, Wang, Li-Dong and Li, Feng (2013). Overexpression of PLCE1 in Kazakh esophageal squamous cell carcinoma: implications in cancer metastasis and aggressiveness. Apmis, 121 (10), 908-918. doi: 10.1111/apm.12095

Polymer nanocarrier system for endosome escape and timed release of siRNA with complete gene silencing and cell death in cancer cells

Gu, Wenyi, Jia, Zhongfan, Truong, Nghia P., Prasadam, Indira, Xiao, Yin and Monteiro, Michael J. (2013). Polymer nanocarrier system for endosome escape and timed release of siRNA with complete gene silencing and cell death in cancer cells. Biomacromolecules, 14 (10), 3386-3389. doi: 10.1021/bm401139e

An influenza virus-inspired polymer system for the timed release of siRNA

Truong, Nghia P., Gu, Wenyi, Prasadam, Indira, Jia, Zhongfan, Crawford, Ross, Xiao, Yin and Monteiro, Michael J. (2013). An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications, 4 (1) 1902, 1902. doi: 10.1038/ncomms2905

MicroRNA-182 plays an onco-miRNA role in cervical cancer

Tang, Tao, Wong, Hoi Kin, Gu, Wenyi, Yu, Mei-yung, To, Ka-Fai, Wang, Chi Chiu, Wong, Yick Fu, Cheung, Tak Hong, Chung, Tony Kwok Hung and Choy, Kwong Wai (2013). MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecologic Oncology, 129 (1), 199-208. doi: 10.1016/j.ygyno.2012.12.043

Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses

Yan, Shiyu, Gu, Wenyi and Xu, Zhi Ping (2013). Re-considering how particle size and other properties of antigen-adjuvant complexes impact on the immune responses. Journal of Colloid and Interface Science, 395 (1), 1-10. doi: 10.1016/j.jcis.2012.11.061

Timed-release polymer nanoparticles

Nguyen, Tran T. D., Nghia, Truong P., Gu, Wenyi, Jia, Zhongfan, Cooper, Matthew A. and Monteiro, Michael J. (2013). Timed-release polymer nanoparticles. Biomacromolecules, 14 (2), 495-502. doi: 10.1021/bm301721k

Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

Yu, Meihua, Jambhrunkar, Siddharth, Thorn, Peter, Chen, Jiezhong, Gu, Wenyi and Yu, Chengzhong (2013). Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanoscale, 5 (1), 178-183. doi: 10.1039/c2nr32145a

Mesenchymal stem cells and nano-structured surfaces

Zhou, Yinghong, Chakravorty, Nishant, Xiao, Yin and Gu, Wenyi (2013). Mesenchymal stem cells and nano-structured surfaces. Methods in Molecular Biology, 1058, 133-48. doi: 10.1007/7651_2013_30

Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration

Gu, Wenyi, Wu, Chengtie, Chen, Jiezhong and Xiao, Yin (2013). Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration. International Journal of Nanomedicine, 8 (1), 2305-2317. doi: 10.2147/IJN.S44393

Obesity-associated endometrial and cervical cancers

Gu, Wenyi, Chen, Chen and Zhao, Kong-Nan (2013). Obesity-associated endometrial and cervical cancers. Frontiers in Bioscience, 5 (1) E600, 109-118. doi: 10.2741/e600

Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymers

Qian, Kun, Liu, Fang, Yang, Jie, Huang, Xiaodan, Gu, Wenyi, Jambhrunkar, Siddharth, Yuan, Pei and Yu, Chengzhong (2013). Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymers. RSC Advances, 3 (34), 14466-14472. doi: 10.1039/c3ra41332b

Recent advance in silica-based engineered nanoparticles for gene therapy

Niu, Yuting, Popat, Amirali, Yu, Meihua, Karmakar, Surajit, Gu, Wenyi and Yu, Chengzhong (2012). Recent advance in silica-based engineered nanoparticles for gene therapy. Therapeutic Delivery, 3 (10), 1217-1237. doi: 10.4155/tde.12.98

A simple approach to prepare monodisperse mesoporous silica nanospheres with adjustable sizes

Yu, Meihua, Zhou, Liang, Zhang, Jun, Yuan, Pei, Thorn, Peter, Gu, Wenyi and Yu, Chengzhong (2012). A simple approach to prepare monodisperse mesoporous silica nanospheres with adjustable sizes. Journal of Colloid and Interface Science, 376 (1), 67-75. doi: 10.1016/j.jcis.2012.03.014

Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery

Hartono, Sandy B., Gu, Wenyi, Kleitz, Freddy, Liu, Jian, He, Lizhong, Middelberg, Anton P. J., Yu, Chengzhong, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012). Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. ACS Nano, 6 (3), 2104-2117. doi: 10.1021/nn2039643

Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheres

Qian, Kun, Gu, Wenyi, Yuan, Pei, Liu, Fang, Wang, Yunhua, Monteiro, Michael and Yu, Chengzhong (2012). Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheres. Small, 8 (2), 231-236. doi: 10.1002/smll.201101770

TNF-alpha promotes IFN-gamma-induced CD40 expression and antigen process in Myb-transformed hematological cells

Gu, Wenyi, Chen, Jeizhong, Yang, Lei and Zhao, Kong-Nan (2012). TNF-alpha promotes IFN-gamma-induced CD40 expression and antigen process in Myb-transformed hematological cells. The Scientific World Journal, 2012 621969, 621969.1-621969.11. doi: 10.1100/2012/621969

The possible mechanisms for β-glucans to prevent atherosclerotic lesions

Gislette, Tiphaine, Zhao, Kong-Nan, Gu, Wenyi and Chen, Jiezhong (2012). The possible mechanisms for β-glucans to prevent atherosclerotic lesions. Current Bioactive Compounds, 8 (2), 146-150. doi: 10.2174/157340712801784796

Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability

Gu, W., Yeo, E., McMillan, N. and Yu, C. (2011). Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability. Cancer Gene Therapy, 18 (12), 897-905. doi: 10.1038/cgt.2011.58

The role of PI3K/Akt pathway in beta-glucan-induced dendritic cell maturation

Chen, Jiezhong, Gu, Wenyi and Zhao, Kongnan (2011). The role of PI3K/Akt pathway in beta-glucan-induced dendritic cell maturation. International Immunopharmacology, 11 (4), 529-529. doi: 10.1016/j.intimp.2011.01.027

Prediction of conserved microRNAs from skin and mucosal human papillomaviruses

Gu, Wenyi, An, Jiyuan, Ye, Ping, Zhao, KongNan and Antonsson, Annika (2011). Prediction of conserved microRNAs from skin and mucosal human papillomaviruses. Archives of Virology, 156 (7), 1161-1171. doi: 10.1007/s00705-011-0974-3

Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs

Gu, Wenyi, Payne, Elizabeth, Sun, Surong, Burgess, Melinda and McMillan, Nigel A. J. (2011). Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs. Cancer Gene Therapy, 18 (3), 219-227. doi: 10.1038/cgt.2010.72

Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes

Ding, Jianmin, Doorbar, John, Li, Bo, Zhou, Fang, Gu, Wenyi, Zhao, Liang, Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2010). Expression of papillomavirus L1 proteins regulated by authentic gene codon usage is favoured in G2/M-like cells in differentiating keratinocytes. Virology, 399 (1), 46-58. doi: 10.1016/j.virol.2009.12.021

Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham, Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert and McMillan, Nigel (2009). Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 106 (20), 8314-8319. doi: 10.1073/pnas.0812085106

siRNA and shRNA as anticancer agents in a cervical cancer model

Gu, Wenyi, Putral, Lisa and McMillan, Nigel (2008). siRNA and shRNA as anticancer agents in a cervical cancer model. Methods in Molecular Biology, 442, 159-172. doi: 10.1007/978-1-59745-191-8_12

Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation

Gu, Wenyi, Ding, Jianmin M., Wang, Xiao, de Kluyver, Rachel L., Saunders, Nicholas A., Frazer, Ian H. and Zhao, Kong-Nan (2007). Generalized substitution of isoencoding codons shortens the duration of papillomavirus L1 protein expression in transiently gene-transfected keratinocytes due to cell differentiation. Nucleic Acids Research, 35 (14), 4820-4832. doi: 10.1093/nar/gkm496

Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes

Fang, N. X., Gu, W., Ding, J., Saunders, N. A., Frazer, I. H. and Zhao, K. N. (2007). Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes. Virology, 365 (1), 187-197. doi: 10.1016/j.virol.2007.03.038

The development and future of oligonucleotide-based therapies for cervical cancer

Gu, W. Y., Putral, L. N., Irving, A. and McMillan, N. A. J. (2007). The development and future of oligonucleotide-based therapies for cervical cancer. Current Opinions in Molecular Therapeutics, 9 (2), 126-131.

Future of RNAi-based therapies for human papillomavirus-associated cervical cancer

Irving, A, McMillan, N and Gu, WY (2007). Future of RNAi-based therapies for human papillomavirus-associated cervical cancer. Future Virology, 2 (6), 587-595. doi: 10.2217/17460794.2.6.587

Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes

Gu, W., Putral, L., Hengst, K., Minto, K., Saunders, N. A., Leggatt, G. and McMillan, N. A. J. (2006). Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes. Cancer Gene Therapy, 13 (11), 1023-1032. doi: 10.1038/sj.cgt.7700971

RNA interference for the treatment of cancer

Putral, Lisa N., Gu, Wenyi and McMillan, Nigel A. J. (2006). RNA interference for the treatment of cancer. Drug News & Perspectives, 19 (6), 317-324. doi: 10.1358/dnp.2006.19.6.985937

Lymphocytes and MHC class II positive cells in the female rabbit reproductive tract before and after ovulation

Gu, Wenyi, Janssens, Peter, Holland, Michael, Seamark, Robert and Kerr, Peter (2005). Lymphocytes and MHC class II positive cells in the female rabbit reproductive tract before and after ovulation. Immunology and Cell Biology, 83 (6), 596-606. doi: 10.1111/j.1440-1711.2005.01375.x

Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo

Zhao, Kong-Nan, Gu, WenYi, Fang, Ning Xia, Saunders, Nicholas A. and Frazer, Ian H. (2005). Gene codon composition determines differentiation-dependent expression of a viral capsid gene in keratinocytes in vitro and in vivo. Molecular And Cellular Biology, 25 (19), 8643-8655. doi: 10.1128/MCB.25.19.8643-8655.2005

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin

Putral, L. N., Bywater, M. J., Gu, W. Y., Saunders, N. A., Gabrielli, B. G., Leggatt, G. R. and McMillan, N. A. J. (2005). RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Molecular Pharmacology, 68 (5), 1311-1319. doi: 10.1124/mol.105.014191

Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection

Jonsson, Julie R., Gu, Wenyi, Vanags, Daina M., Bishop, G. Alex, McCaughan, Geoffrey W., Fawcett, Jonathon, Lynch, Stephen V., Balderson, Glenda A., Powell, Elizabeth E. and Clouston, Andrew D. (2004). Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection. Liver Transplantation, 10 (3), 397-403. doi: 10.1002/lt.20084

Immune response in rabbit ovaries following infection of a recombinant myxoma virus expressing rabbit zona pellucida protein B

Gu, Wenyi, Holland, Michael, Janssens, Peter, Seamark, Robert and Kerr, Peter (2004). Immune response in rabbit ovaries following infection of a recombinant myxoma virus expressing rabbit zona pellucida protein B. Virology, 318 (2), 516-523. doi: 10.1016/j.virol.2003.10.021

tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes

Gu, Wenyi, Li, Mengrong, Zhao, Wei Ming, Fang, Ning Xia, Bu, Shurui, Frazer, Ian H. and Zhao, Kong-Nan (2004). tRNASer(CGA) differentially regulates expression of wild-type and codon-modified papillomavirus L1 genes. Nucleic Acids Research, 32 (15), 4448-4461. doi: 10.1093/nar/gkh748

Effects of additional sequences directly downstream from the AUG on the expression of GFP gene

Zhao, Kong-Nan, Tomlinson, Liz, Liu, Wen Jun, Gu, Wenyi and Frazer, Ian H. (2003). Effects of additional sequences directly downstream from the AUG on the expression of GFP gene. BBA - Biochimeca et Biophysica Acta: international journal of biochemistry and biophysics, 1630 (2-3), 84-95. doi: 10.1016/j.bbaexp.2003.09.010

Antibody response in the female rabbit reproductive tract to influenza haemagglutinin encoded by a recombinant myxoma virus

Gu, Wenyi, Holland, Michael, Janssens, Peter and Kerr, Peter (2003). Antibody response in the female rabbit reproductive tract to influenza haemagglutinin encoded by a recombinant myxoma virus. Virology, 313 (1), 286-295. doi: 10.1016/S0042-6822(03)00324-6

Efficient drug delivery for cancer treatment using Si02-LDH nanocomposites

Li, L., Gu, Z., Gu, W. Y., Liu, J. and Xu, Z. P. (2015). Efficient drug delivery for cancer treatment using Si02-LDH nanocomposites. 10th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 18th Annual Nanotech Conference and Expo, and the 2015 National SBIR/STTR Conference, Washington, DC, United States, 14-17 June 2015. Taylor and Francis.

RNA interference for the treatment of cervical cancers: Solving the delivery and efficacy issues

Gu, W. Y., Leggatt, G., Payne, E., Wilson, D., Choyce, A. and McMillan, N. A. J. (2009). RNA interference for the treatment of cervical cancers: Solving the delivery and efficacy issues. 6th Meeting of the Australasian Gene Therapy Society, Sydney, Australia, 29 April - 01 May 2009. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/jgm.1375

Absence of rejection after human liver orthotopic liver transplantation (OLT) is associated with leukocyte apoptosis, increased lymphocyte activation and higher donor cell chimerism

Clouston, A., Vanags, D. M., Gu, W. Y., Powell, E. E. and Jonsson, J. R. (2003). Absence of rejection after human liver orthotopic liver transplantation (OLT) is associated with leukocyte apoptosis, increased lymphocyte activation and higher donor cell chimerism. 55th Annual Meeting of the American-Association-for-the-Study-of-Liver-Disease, Boston, MA, United States, 24-28 October 2003. Hoboken, NJ, United States: John Wiley & Sons.

Polymers for siRNA delivery

Monteiro, Michael, Gu, W., Phuoc, T. and Jia, Z. (2014). Polymers for siRNA delivery. WO2014015367.