The University of Queensland

Fast NMR data acquisition: beyond the Fourier transform

Mehdi Mobli and Jeffrey C. Hoch eds. (2017). Fast NMR data acquisition: beyond the Fourier transform. New Developments in NMR, Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781782628361

Modelling H NMR Spectra of Organic Compounds: Theory, Applications and NMR Prediction Software

Abraham, Raymond J. and Mobli, Mehdi (2008). Modelling H NMR Spectra of Organic Compounds: Theory, Applications and NMR Prediction Software. Chichester, UK: John Wiley and Sons. doi: 10.1002/9780470721803

Modelling 1H NMR spectra of organic compounds: Theory, applications and NMR prediction software

Abraham, Raymond and Mobli, Mehdi (2008). Modelling 1H NMR spectra of organic compounds: Theory, applications and NMR prediction software. Chichester: Wiley.

Nonuniform sampling in biomolecular NMR

Miljenovic, Tomas Marko, Jia, Xinying and Mobli, Mehdi (2018). Nonuniform sampling in biomolecular NMR. Modern magnetic resonance. (pp. 2035-2054) edited by Graham A. Webb. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-28388-3_118

Fast NMR data acquisition: beyond the Fourier transform: Preface

Mobli, Mehdi and Hoch, Jeffrey C. (2017). Fast NMR data acquisition: beyond the Fourier transform: Preface. Fast NMR data acquisition: beyond the Fourier transform. (pp. VIII-X) edited by Mehdi Mobli and Jeffrey C. Hoch. Cambridge, United Kingdom: Royal Society of Chemistry.

Maximum entropy reconstruction

Mobli, Mehdi, Stern, Alan S. and Hoch, Jeffrey C. (2017). Maximum entropy reconstruction. Fast NMR data acquisition: beyond the Fourier transform. (pp. 252-266) edited by Mehdi Mobli and Jeffrey C. Hoch. Cambridge, United Kingdom: Royal Society of Chemistry.

Research methods

Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.

The Structural Universe of Disulfide-Rich Venom Peptides

Lavergne, Vincent, Alewood, Paul F., Mobli, Mehdi and King, Glenn F. (2015). The Structural Universe of Disulfide-Rich Venom Peptides. Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. (pp. 37-79) edited by King, Glenn F.. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00037

Data sampling in multidimensional NMR: fundamentals and strategies

Maciejewski, Mark W., Mobli, Mehdi, Schuyler, Adam D., Stern, Alan S. and Hoch, Jeffrey C. (2012). Data sampling in multidimensional NMR: fundamentals and strategies. Novel sampling approaches in higher dimensional NMR. (pp. 49-77) edited by Martin Billeter and Vladislav Orekhov. Heidelberg, Germany: Springer. doi: 10.1007/128_2011_185

Nonuniform sampling in multidimensional NMR

Hoch, Jeffrey C., Maciejewski, Mark W., Mobli, Mehdi, Schyler, Adam D. and Stern, Alan S. (2012). Nonuniform sampling in multidimensional NMR. EMagRes. (pp. 1-2) London, United Kingdom: John Wiley & Sons. doi: 10.1002/9780470034590.emrstm1239

Fast acquisition methods in multidimensional NMR

Mobli, Mehdi, Hoch, Jeffrey C. and King, Glenn F. (2011). Fast acquisition methods in multidimensional NMR. Biomolecular NMR spectroscopy. (pp. 305-337) edited by Andrew J. Dingley and Steven M. Pascal. Amsterdam , Netherlands: IOS Press. doi: 10.3233/978-1-60750-695-9-305

Maximum Entropy Reconstruction

Hoch, Jeffrey C., Stern, Alan S. and Mobli, Mehdi (2011). Maximum Entropy Reconstruction. eMagRes. (pp. 1-6) United Kingdom: John Wiley and Sons. doi: 10.1002/9780470034590.emrstm0299.pub2

Determination of peptide and protein structures using NMR Spectroscopy

King, Glenn F and Mehdi Mobli (2010). Determination of peptide and protein structures using NMR Spectroscopy. Comprehensive natural products II: Chemistry and biology. (pp. 280-325) edited by Lewis Mander and Hung-Wen Liu. Oxford, England: Elsevier Science & Technology Books. doi: 10.1016/B978-008045382-8.00653-5

Maximum Entropy: Multidimensional Methods

Hoch, Jeffrey C. and Mobli, Mehdi (2009). Maximum Entropy: Multidimensional Methods. EMagRes. (pp. 1-8) United Kingdom: John Wiley & Sons. doi: 10.1002/9780470034590.emrstm1158

Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation

Jia, Xinying, Chin, Yanni K.-Y., Zhang, Alan H., Crawford, Theo, Zhu, Yifei, Fletcher, Nicholas L., Zhou, Zihan, Hamilton, Brett R., Stroet, Martin, Thurecht, Kristofer J. and Mobli, Mehdi (2023). Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation. Communications Chemistry, 6 (1) 48, 1-10. doi: 10.1038/s42004-023-00841-5

Structural Basis of the Bivalency of the TRPV1 Agonist DkTx

Ramanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2023). Structural Basis of the Bivalency of the TRPV1 Agonist DkTx. Angewandte Chemie International Edition. doi: 10.1002/anie.202314621

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH

Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

Designing antimicrobial peptides using deep learning and molecular dynamic simulations

Cao, Qiushi, Ge, Cheng, Wang, Xuejie, Harvey, Peta J., Zhang, Zixuan, Ma, Yuan, Wang, Xianghong, Jia, Xinying, Mobli, Mehdi, Craik, David J., Jiang, Tao, Yang, Jinbo, Wei, Zhiqiang, Wang, Yan, Chang, Shan and Yu, Rilei (2023). Designing antimicrobial peptides using deep learning and molecular dynamic simulations. Briefings in Bioinformatics, 24 (2) bbad058, 1-13. doi: 10.1093/bib/bbad058

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR

Kuschert, Sarah, Stroet, Martin, Chin, Yanni Ka-Yan, Conibear, Anne Claire, Jia, Xinying, Lee, Thomas, Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Güntert, Peter, Rosengren, Karl Johan, Mark, Alan Edward and Mobli, Mehdi (2023). Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR. Magnetic Resonance, 4 (1), 57-72. doi: 10.5194/mr-4-57-2023

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w

Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2

Bartling, Christian R. O., Alexopoulou, Flora, Kuschert, Sarah, Chin, Yanni K.-Y., Jia, Xinying, Sereikaite, Vita, Özcelik, Dennis, Jensen, Thomas M., Jain, Palash, Nygaard, Mads M., Harpsøe, Kasper, Gloriam, David E., Mobli, Mehdi and Strømgaard, Kristian (2023). Comprehensive peptide cyclization examination yields optimized APP scaffolds with improved affinity toward Mint2. Journal of Medicinal Chemistry, 66 (4), 3045-3057. doi: 10.1021/acs.jmedchem.2c02017

ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides

Liu, Junyu, Maxwell, Michael, Cuddihy, Thom, Crawford, Theo, Bassetti, Madeline, Hyde, Cameron, Peigneur, Steve, Tytgat, Jan, Undheim, Eivind A.B. and Mobli, Mehdi (2023). ScrepYard: an online resource for disulfide-stabilised tandem repeat peptides. Protein Science, 32 (2) e4566, 1-12. doi: 10.1002/pro.4566

Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase

Peck, Yoshimi, Pickering, Darren, Mobli, Mehdi, Liddell, Michael J., Wilson, David T., Ruscher, Roland, Ryan, Stephanie, Buitrago, Geraldine, McHugh, Connor, Love, Nicholas C., Pinlac, Theresa, Haertlein, Michael, Kron, Michael A., Loukas, Alex and Daly, Norelle L. (2023). Solution structure of the N-terminal extension domain of a Schistosoma japonicum asparaginyl-tRNA synthetase. Journal of Biomolecular Structure and Dynamics, 1-11. doi: 10.1080/07391102.2023.2241918

Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes

Mohanty, Biswaranjan, Orts, Julien, Wang, Geqing, Nebl, Stefan, Alwan, Wesam S., Doak, Bradley C., Williams, Martin L., Heras, Begoña, Mobli, Mehdi and Scanlon, Martin J. (2022). Methyl probes in proteins for determining ligand binding mode in weak protein–ligand complexes. Scientific Reports, 12 (1) 11231, 1-10. doi: 10.1038/s41598-022-13561-y

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

Healy, Michael D., Sacharz, Joanna, McNally, Kerrie E., McConville, Calum, Tillu, Vikas A., Hall, Ryan J., Chilton, Molly, Cullen, Peter J., Mobli, Mehdi, Ghai, Rajesh, Stroud, David A. and Collins, Brett M. (2022). Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins. Structure, 30 (12), 1590-1602.e6. doi: 10.1016/j.str.2022.10.001

The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

Liu, Liping, Lucas, Richard M., Nanson, Jeffrey D., Li, Yan, Whitfield, Jason, Curson, James E. B., Tuladhar, Neeraj, Alexandrov, Kirill, Mobli, Mehdi, Sweet, Matthew J., Kobe, Bostjan, Stow, Jennifer and Luo, Lin (2022). The transmembrane adaptor SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs. Journal of Biological Chemistry, 298 (5) 101857, 101857. doi: 10.1016/j.jbc.2022.101857

NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR

Pustovalova, Yulia, Delaglio, Frank, Craft, D. Levi, Arthanari, Haribabu, Bax, Ad, Billeter, Martin, Bostock, Mark J., Dashti, Hesam, Hansen, D. Flemming, Hyberts, Sven G., Johnson, Bruce A., Kazimierczuk, Krzysztof, Lu, Hengfa, Maciejewski, Mark, Miljenović, Tomas M., Mobli, Mehdi, Nietlispach, Daniel, Orekhov, Vladislav, Powers, Robert, Qu, Xiaobo, Robson, Scott Anthony, Rovnyak, David, Wagner, Gerhard, Ying, Jinfa, Zambrello, Matthew, Hoch, Jeffrey C., Donoho, David L. and Schuyler, Adam D. (2021). NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR. Magnetic Resonance, 2 (2), 843-861. doi: 10.5194/mr-2-843-2021

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1

Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009

Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling

Huerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765

Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor

Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148

An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

Pineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117

Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions

Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002

Residual dipolar couplings for resolving cysteine bridges in disulfide-rich peptides

Ramanujam, Venkatraman, Shen, Yang, Ying, Jinfa and Mobli, Mehdi (2020). Residual dipolar couplings for resolving cysteine bridges in disulfide-rich peptides. Frontiers in Chemistry, 7 889, 1-13. doi: 10.3389/fchem.2019.00889

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Elnahriry, Khaled A., Wai, Dorothy C.C., Krishnarjuna, Bankala, Badawy, Noha N., Chittoor, Balasubramanyam, MacRaild, Christopher A., Williams-Noonan, Billy J., Surm, Joachim M., Chalmers, David K., Zhang, Alan H., Peigneur, Steve, Mobli, Mehdi, Tytgat, Jan, Prentis, Peter and Norton, Raymond S. (2019). Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa. Toxicon, 168, 104-112. doi: 10.1016/j.toxicon.2019.07.002

A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins

Jia, Xinying, Crawford, Theo, Zhang, Alan H. and Mobli, Mehdi (2019). A new vector coupling ligation-independent cloning with sortase a fusion for efficient cloning and one-step purification of tag-free recombinant proteins. Protein Expression and Purification, 161, 1-7. doi: 10.1016/j.pep.2019.04.004

Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs

Zhang, Alan H., Edwards, Ingrid A., Mishra, Biswa P., Sharma, Gagan, Healy, Michael D., Elliott, Alysha, Blaskovich, Mark A. T., Cooper, Matthew A., Collins, Brett M., Jia, Xinying and Mobli, Mehdi (2019). Elucidating the lipid binding properties of membrane-active peptides using cyclised nanodiscs. Frontiers in Chemistry, 7 (MAR) 238, 238. doi: 10.3389/fchem.2019.00238

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y

Optimizing the transformation of HYSCORE data using the maximum entropy algorithm

Motygullina, Alina E., Mobli, Mehdi and Harmer, Jeffrey R. (2019). Optimizing the transformation of HYSCORE data using the maximum entropy algorithm. Journal of Magnetic Resonance, 301, 30-39. doi: 10.1016/j.jmr.2019.02.002

Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma

Crawford, Theo, Fletcher, Nicholas, Veitch, Margaret, Gonzalez Cruz, Jazmina L., Pett, Nicola, Brereton, Ian, Wells, James W., Mobli, Mehdi and Tesiram, Yasvir (2019). Bacillus anthracis Protective Antigen Shows High Specificity for a UV Induced Mouse Model of Cutaneous Squamous Cell Carcinoma. Frontiers in Medicine, 6 (FEB) 22, 22. doi: 10.3389/fmed.2019.00022

Video with impact: access to the world's Magnetic-Resonance experts for the scientific-education community

Kwan, Ann H., Mobli, Mehdi, Schirra, Horst J., Wilson, Jennifer C. and Jones, Oliver A. H. (2019). Video with impact: access to the world's Magnetic-Resonance experts for the scientific-education community. Journal of Chemical Education, 96 (1), 159-164. doi: 10.1021/acs.jchemed.8b00523

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Brinson, Robert G., Marino, John P., Delaglio, Frank, Arbogast, Luke W., Evans, Ryan M., Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K., Jia, Xinying, Mobli, Mehdi, Grant, Hamish G., Keizer, David W., Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R., Lawrence, Chad W., Reardon, Patrick N., Cort, John R., Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R., Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny ... Wikström, Mats (2019). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. mAbs, 11 (1), 94-105. doi: 10.1080/19420862.2018.1544454

Framework for and evaluation of bursts in random sampling of multidimensional NMR experiments

Mobli, M. and Miljenovic, Tomas M. (2019). Framework for and evaluation of bursts in random sampling of multidimensional NMR experiments. Journal of Magnetic Resonance, 300, 103-113. doi: 10.1016/j.jmr.2019.01.014

Secreted cysteine-rich repeat proteins "SCREPs": a novel multi-domain architecture

Maxwell, Michael, Undheim, Eivind A. B. and Mobli, Mehdi (2018). Secreted cysteine-rich repeat proteins "SCREPs": a novel multi-domain architecture. Frontiers in Pharmacology, 9 (NOV) 01333, 1333. doi: 10.3389/fphar.2018.01333

Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Tian, Wenya, Sun, Chenghai, Zheng, Mei, Harmer, Jeffrey R., Yu, Mingjia, Zhang, Yanan, Peng, Haidong, Zhu, Dongqing, Deng, Zixin, Chen, Shi-Lu, Mobli, Mehdi, Jia, Xinying and Qu, Xudong (2018). Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids. Nature Communications, 9 (1) 4428, 4428. doi: 10.1038/s41467-018-06528-z

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Herzig, Volker, de Araujo, Aline, Greenwood, Kathryn, Chin, Yanni, Windley, Monique, Chong, Youmie, Muttenthaler, Markus, Mobli, Mehdi, Audsley, Neil, Nicholson, Graham, Alewood, Paul and King, Glenn (2018). Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides. Biomedicines, 6 (3) 90, 90. doi: 10.3390/biomedicines6030090

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F. and Petrou, Steven (2018). Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death. Proceedings of the National Academy of Sciences, 115 (34), 201804764-E8085. doi: 10.1073/pnas.1804764115

Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660)

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2018). Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660). Angewandte Chemie - International Edition, 57 (19), 5203-5203. doi: 10.1002/anie.201803138

A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors

Zhang, Alan H., Sharma, Gagan, Undheim, Eivind A. B., Jia, Xinying and Mobli, Mehdi (2018). A complicated complex: ion channels, voltage sensing, cell membranes and peptide inhibitors. Neuroscience Letters, 679, 35-47. doi: 10.1016/j.neulet.2018.04.030

Structural insights into the mechanism of inhibition of AHAS by herbicides

Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018). Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 (9), E1945-E1954. doi: 10.1073/pnas.1714392115

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

Hughes, Mark M., Lavrencic, Peter, Coll, Rebecca C., Ve, Thomas, Ryan, Dylan G., Williams, Niamh C., Menon, Deepthi, Mansell, Ashley, Board, Philip G., Mobli, Mehdi, Kobe, Bostjan and O'Neill, Luke A. J. (2017). Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling. Proceedings of the National Academy of Sciences, 114 (32), E6480-E6489. doi: 10.1073/pnas.1701868114

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, Thomas, Vajjhala, Parimala, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P., Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J., Stacey, Katryn, Egelman, Edward H. and Kobe, Bostjan (2017). Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling. Nature Structural and Molecular Biology, 24 (9), 743-751. doi: 10.1038/nsmb.3444

Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1

Franke, Bastian, James, Amy M., Mobli, Mehdi, Colgrave, Michelle L., Mylne, Joshua S. and Rosengren, K. Johan (2017). Two proteins for the price of one: structural studies of the dual-destiny protein preproalbumin with sunflower trypsin inhibitor-1. The Journal of Biological Chemistry, 292 (30), 12398-12411. doi: 10.1074/jbc.M117.776955

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

Modulation of ion channels by cysteine-rich peptides: from sequence to structure

Mobli, Mehdi, Undheim, Eivind A.B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Advances in Pharmacology, 79, 199-223. doi: 10.1016/bs.apha.2017.03.001

The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant

Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114

A non-uniform sampling approach enables studies of dilute and unstable proteins

Miljenović, Tomas, Jia, Xinying, Lavrencic, Peter, Kobe, Bostjan and Mobli, Mehdi (2017). A non-uniform sampling approach enables studies of dilute and unstable proteins. Journal of Biomolecular NMR, 68 (2), 1-9. doi: 10.1007/s10858-017-0091-z

Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses

Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407

NaV1.7 as a pain target – from gene to pharmacology

Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

Casey, Lachlan W., Lavrencic, Peter, Bentham, Adam R., Cesari, Stella, Ericsson, Daniel J., Croll, Tristan, Turk, Dušan, Anderson, Peter A., Mark, Alan E., Dodds, Peter N., Mobli, Mehdi, Kobe, Bostjan and Williams, Simon J. (2016). The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins. Proceedings of the National Academy of Sciences, 113 (45), 12856-12861. doi: 10.1073/pnas.1609922113

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Vazirani, Mansha, Ilyichova, Olga, Wang, Geqing, Bermel, Wolfgang, Simpson, Jamie S., Chalmers, David K., King, Glenn F., Mobli, Mehdi and Scanlon, Martin J. (2016). Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data. Journal of Biomolecular NMR, 66 (3), 195-208. doi: 10.1007/s10858-016-0067-4

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels

Lau, Carus H.Y., King, Glenn F and Mobli, Mehdi (2016). Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels. Scientific Reports, 6 (1) 34333, 34333. doi: 10.1038/srep34333

Correction: Sparse sampling methods in multidimensional NMR

Mobli, Mehdi, Maciejewski, Mark W, Schuyler, Adam D, Stern, Alan S and Hoch, Jeffrey C (2016). Correction: Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 18 (28), 19482-19482. doi: 10.1039/c6cp90157c

Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides

Undheim, Eivind A., Mobli, Mehdi and King, Glenn F. (2016). Toxin structures as evolutionary tools: Using conserved 3D folds to study the evolution of rapidly evolving peptides. Bioessays, 38 (6), 539-548. doi: 10.1002/bies.201500165

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

Wan, Jingjing, Brust, Andreas, Bhola, Rebecca F., Jha, Prerna, Mobli, Mehdi, Lewis, Richard J., Christie, Macdonald J. and Alewood, Paul F. (2016). Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science, 22 (5), 280-289. doi: 10.1002/psc.2857

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target na(v)1.7

Klint, Julie K., Chin, Yanni K. -Y. and Mobli, Mehdi (2015). Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target na(v)1.7. Molecular Pharmacology, 88 (6), 1002-1010. doi: 10.1124/mol.115.100784

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a

Saez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267

Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators

Undheim, Eivind A. B., Grimm, Lena L., Low, Chek -Fong, Morgenstern, David, Herzig, Volker, Zobel-Thropp, Pamela, Pineda, Sandy Steffany, Habib, Rosaline, Dziemborowicz, Slawomir, Fry, Bryan G., Nicholson, Graham M., Binford, Greta J., Mobli, Mehdi and King, Glenn F. (2015). Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators. Structure, 23 (7) 3184, 1283-1292. doi: 10.1016/j.str.2015.05.003

Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data

Mobli, Mehdi (2015). Reducing seed dependent variability of non-uniformly sampled multidimensional NMR data. Journal of Magnetic Resonance, 256, 60-69. doi: 10.1016/j.jmr.2015.04.003

Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition

Sawyer, Anne L., Landsberg, Michael J., Ross, Ian L., Kruse, Olaf, Mobli, Mehdi and Hankamer, Ben (2015). Solution structure of the RNA-binding cold shock domain of the Chlamydomonas reinhardtii NAB1 protein and insights into RNA recognition. Biochemical Journal, 469 (1), 97-106. doi: 10.1042/BJ20150217

Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ

Nogueira, Maria Luiza C., Sforca, Mauricio Luis, Chin, Yanni K. -Y., Mobli, Mehdi, Handler, Aaron, Gorbatyuk, Vitaliy Y., Robson, Scott A., King, Glenn F., Gueiros-Filho, Frederico J. and de Mattos Zeri, Ana Carolina (2015). Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ. Biomolecular NMR Assignments, 9 (2), 387-391. doi: 10.1007/s12104-015-9615-1

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081

RNA polymerase-induced remodelling of NusA produces a pause enhancement complex

Ma, Cong, Mobli, Mehdi, Yang, Xiao, Keller, Andrew N., King, Glenn F. and Lewis, Peter J. (2015). RNA polymerase-induced remodelling of NusA produces a pause enhancement complex. Nucleic Acids Research, 43 (5), 2829-2840. doi: 10.1093/nar/gkv108

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop

Bende, Niraj S., Dziemborowicz, Slawomir, Herzig, Volker, Ramanujam, Venkatraman, Brown, Geoffrey W., Bosmans, Frank, Nicholson, Graham M., King, Glenn F. and Mobli, Mehdi (2015). The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop. FEBS Journal, 282 (5), 904-920. doi: 10.1111/febs.13189

Erratum to "Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR" [Prog. Nucl. Magn. Reson. Spectrosc. 83 (2014) 21-41]

Mobli, Mehdi and Hoch, Jeffrey C. (2015). Erratum to "Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR" [Prog. Nucl. Magn. Reson. Spectrosc. 83 (2014) 21-41]. Progress in Nuclear Magnetic Resonance Spectroscopy, 86-87, 80-80. doi: 10.1016/j.pnmrs.2015.02.001

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors

Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244

Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR

Mobli, Mehdi and Hoch, Jeffrey C. (2014). Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 83, 21-41. doi: 10.1016/j.pnmrs.2014.09.002

Molecular insights into the interaction between plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, Geqing, MacRaild, Christopher A., Mohanty, Biswaranjan, Mobli, Mehdi, Cowieson, Nathan P., Anders, Robin F., Simpson, Jamie S., McGowan, Sheena, Norton, Raymond S. and Scanlon, Martin J. (2014). Molecular insights into the interaction between plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide. PLoS One, 9 (10) e109674, 1-12. doi: 10.1371/journal.pone.0109674

Non-uniform sampling in EPR-optimizing data acquisition for HYSCORE spectroscopy

Nakka, K. K., Tesiram, Y. A., Brereton, I. M., Mobli, M. and Harmer, J. R. (2014). Non-uniform sampling in EPR-optimizing data acquisition for HYSCORE spectroscopy. Physical Chemistry Chemical Physics, 16 (31), 16378-16382. doi: 10.1039/c4cp02172j

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Bende, Niraj S., Dziemborowicz, Sławomir, Mobli, Mehdi, Herzig, Volker, Gilchrist, John, Wagner, Jordan, Nicholson, Graham M., King, Glenn F and Bosmans, Frank (2014). A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nature Communications, 5 (1) 4350, 4350. doi: 10.1038/ncomms5350

Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels

Klint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008

Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6

Bobby, Romel, Robustelli, Paul, Kralicek, Andrew V., Mobli, Mehdi, King, Glenn F., Grotzinger, Joachim and Dingley, Andrew J. (2014). Functional implications of large backbone amplitude motions of the glycoprotein 130-binding epitope of interleukin-6. FEBS Journal, 281 (10), 2471-2483. doi: 10.1111/febs.12800

Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl

Dekan, Zoltan, Mobli, Mehdi, Pennington, Michael W., Fung, Eileen, Nemeth, Elizabeta and Alewood, Paul F. (2014). Total synthesis of human hepcidin through regioselective disulfide-bond formation by using the safety-catch cysteine protecting group 4,4'-dimethylsulfinylbenzhydryl. Angewandte Chemie International Edition, 53 (11), 2931-2934. doi: 10.1002/anie.201310103

Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR

Hoch, Jeffrey C., Maciejewski, Mark W., Mobli, Mehdi, Schuyler, Adam D. and Stern, Alan S. (2014). Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR. Accounts of Chemical Research, 47 (2), 708-717. doi: 10.1021/ar400244v

A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain

Gui, Junhong, Liu, Boyi, Cao, Guan, Lipchik, Andrew M., Perez, Minervo, Dekan, Zoltan, Mobli, Mehdi, Daly, Norelle L., Alewood, Paul F., Parker, Laurie L., King, Glenn F., Zhou, Yufeng, Jordt, Sven-Eric and Nitabach, Michael N. (2014). A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1–S4 gating domain. Current Biology, 24 (5), 473-483. doi: 10.1016/j.cub.2014.01.013

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898

Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni

Jia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558

Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules

Ghai, Rajesh, Mobli, Mehdi and Collins, Brett M. (2014). Measuring interactions of FERM domain-containing sorting nexin proteins with endosomal lipids and cargo molecules. Methods in Enzymology, 534, 331-349. doi: 10.1016/B978-0-12-397926-1.00019-6

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165

Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores

Jensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Dantas De Araujo, Aline, Herzig, Volker, Windley, Monique J., Dziemborowicz, Slawomir, Mobli, Mehdi, Nicholson, Graham M., Alewood, Paul F. and King, Glenn F. (2013). Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?. Antioxidants and Redox Signaling, 19 (16), 1976-1980. doi: 10.1089/ars.2013.5365

Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2013). Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Edition), 52 (46), 12020-12023. doi: 10.1002/anie.201304660

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula

Hardy, Margaret C., Daly, Norelle L., Mobli, Mehdi, Morales, Rodrigo A. V. and King, Glenn F. (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula. PLoS ONE, 8 (9), e73136.1-e73136.12. doi: 10.1371/journal.pone.0073136

Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein

Smirnova, Ekaterina, Shanbhag, Riya, Kurabi, Arwa, Mobli, Mehdi, Kwan, Jamie J. and Donaldson, Logan W. (2013). Solution structure and peptide binding of the PTB domain from the AIDA1 postsynaptic signaling scaffolding protein. PLoS ONE, 8 (6) e65605, e65605.1-e65605.8. doi: 10.1371/journal.pone.0065605

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

Klint, Julie K., Senff, Sebastian, Saez, Natalie J., Seshadri, Radha, Lau, Ho Yee, Bende, Nira J., Undheim, Eivind A. B., Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2013). Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli. PLoS One, 8 (5) e63865, e63865.1-e63865.12. doi: 10.1371/journal.pone.0063865

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

Bende, Niraj S., Kang, Eunji, Herzig, Volker, Bosmans, Frank, Nicholson, Graham M., Mobli, Mehdi and King, Glenn F. (2013). The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels. Biochemical Pharmacology, 85 (10), 1542-1554. doi: 10.1016/j.bcp.2013.02.030

Cyclization of peptides by using selenolanthionine bridges

Dantas de Araujo, Aline, Mobli, Mehdi, King, Glenn F. and Alewood, Paul F. (2012). Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie International Edition, 51 (41), 10298-10302. doi: 10.1002/anie.201204229

Sparse sampling methods in multidimensional NMR

Mobli, Mehdi, Maciejewski, Mark W., Schuyler, Adam D., Stern, Alan S. and Hoch, Jeffrey C. (2012). Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 14 (31), 10835-10843. doi: 10.1039/c2cp40174f

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

Anangi, Raveendra, Rash, Lachlan D., Mobli, Mehdi and King, Glenn F. (2012). Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 (7), 1605-1618. doi: 10.3390/md10071605

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2012). Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10 (7), 1511-1527. doi: 10.3390/md10071511

Insulin-like growth factor binding protein 2: NMR analysis and structural characterization of the N-terminal domain

Galea, Charles A., Mobli, Mehdi, McNeil, Kerrie A., Mulhern, Terrence D., Wallace, John C., King, Glenn F., Forbes, Briony E. and Norton, Raymond S. (2012). Insulin-like growth factor binding protein 2: NMR analysis and structural characterization of the N-terminal domain. Biochimie, 94 (3), 608-616. doi: 10.1016/j.biochi.2011.09.012

Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR

Mobli, Mehdi, Morgenstern, David, King, Glenn F., Alewood, Paul F. and Muttenthaler, Markus (2011). Site-specific pKa determination of selenocysteine residues in selenovasopressin using 77Se NMR. Angewandte Chemie (International Edition), 50 (50), 11952-11955. doi: 10.1002/anie.201104169

A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

Saez, Natalie J., Mobli, Mehdi, Bieri, Michael, Chassagnon, Irene R., Malde, Alpeshkumar K., Gamsjaeger, Roland, Mark, Alan E., Gooley, Paul R., Rash. Lachlan D. and King, Glenn F. (2011). A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Molecular Pharmacology, 80 (5), 796-808. doi: 10.1124/mol.111.072207

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

Ghai, Rajesh, Mobli, Mehdi, Norwood, Suzanne J., Bugarcic, Andrea, Teasdale, Rohan D., King, Glenn F. and Collins, Brett M. (2011). Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases. Proceedings of the National Academy of Sciences of the United States of America, 108 (19), 7763-7768. doi: 10.1073/pnas.1017110108

Macromolecular NMR spectroscopy for the non-spectroscopist

Kwan, Ann H., Mobli, Mehdi, Gooley, Paul R., King, Glenn F. and Mackay, Joel P. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist. Febs Journal, 278 (5), 687-703. doi: 10.1111/j.1742-4658.2011.08004.x

Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular structure determination

Bieri, Michael, Kwan, Ann H., Mobli, Mehdi, King, Glenn F., Mackay, Joel P. and Gooley, Paul R. (2011). Macromolecular NMR spectroscopy for the non-spectroscopist: Beyond macromolecular structure determination. Febs Journal, 278 (5), 704-715. doi: 10.1111/j.1742-4658.2011.08005.x

The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation

Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela and Vandenberg, Jamie I. (2011). The N-terminal tail of hERG contains an amphipathic alpha-helix that regulates channel deactivation. PLoS One, 6 (1) e16191, e16191.1-e16191.9. doi: 10.1371/journal.pone.0016191

Venomics: A new paradigm for natural products-based drug discovery

Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4

NMR methods for determining disulfide-bond connectivities

Mobli, Mehdi and King, Glenn F. (2010). NMR methods for determining disulfide-bond connectivities. Toxicon, 56 (6), 849-854. doi: 10.1016/j.toxicon.2010.06.018

Chemical synthesis and structure of the prokineticin Bv8

Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330

A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment

Mobli, Mehdi, Stern, Alan S., Bermel, Wolfgang, King, Glenn F. and Hoch, Jeffrey C. (2010). A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment. Journal of Magnetic Resonance, 204 (1), 160-164. doi: 10.1016/j.jmr.2010.02.012

Derivation of Peptide and Protein Structure using NMR Spectroscopy

King, Glenn F. and Mobli, Mehdi (2010). Derivation of Peptide and Protein Structure using NMR Spectroscopy. Comprehensive Natural Products Ii: Chemistry and Biology, Vol 9: Modern Methods in Natural Products Chemistry, 9, 279-325.

Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy

Mobli, M., Dantas de Araujo, A., Lambert, L. K., Pierens, G. K., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. E. (2009). Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy. Angewandte Chemie International Edition, 48 (49), 9312-9314. doi: 10.1002/anie.200905206

Effective Protocol for Database Similarity Searching of Heteronuclear Single Quantum Coherence Spectra

Pierens, G. K., Mobli, M. and Vegh, V. (2009). Effective Protocol for Database Similarity Searching of Heteronuclear Single Quantum Coherence Spectra. Analytical Chemistry, 81 (22), 9329-9335. doi: 10.1021/ac901616t

A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import

Kurabi, A, Brener, S, Mobli, M, Kwan, J. J. and Donaldson, L. W. (2009). A nuclear localization signal at the SAM-SAM domain interface of AIDA-1 suggests a requirement for domain uncoupling prior to nuclear import. Journal of Molecular Biology, 392 (5), 1168-1177. doi: 10.1016/j.jmb.2009.08.004

Nonuniform sampling and spectral aliasing

Maciejewski, Mark W., Qui, Harry Z., Rujan, Iulian, Mobli, Mehdi and Hoch, Jeffrey C. (2009). Nonuniform sampling and spectral aliasing. Journal of Magnetic Resonance, 199 (1), 88-93. doi: 10.1016/j.jmr.2009.04.006

Maximum entropy spectral reconstruction of nonuniformly sampled data

Mobli, Mehdi and Hoch, Jeffrey C. (2008). Maximum entropy spectral reconstruction of nonuniformly sampled data. Concepts in Magnetic Resonance Part A, 32A (6), 436-448. doi: 10.1002/cmr.a.20126

The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy 15N-NMR relaxation studies

Mobli, Mehdi, Nilsson, Mathias and Almond, Andrew (2008). The structural plasticity of heparan sulfate NA-domains and hence their role in mediating multivalent interactions is confirmed by high-accuracy 15N-NMR relaxation studies. Glycoconjugate Journal, 25 (5), 401-414. doi: 10.1007/s10719-007-9081-9

An NMR, IR and theoretical investigation of 1H Chemical Shifts and hydrogen bonding in phenols

Abraham, Raymond J. and Mobli, Mehdi (2007). An NMR, IR and theoretical investigation of 1H Chemical Shifts and hydrogen bonding in phenols. Magnetic resonance in chemistry, 45 (10), 865-877. doi: 10.1002/mrc.2060

Automatic maximum entropy spectral reconstruction in NMR

Mobli, Mehdi, Maciejewski, Mark W., Gryk, Michael R. and Hoch, Jeffrey C. (2007). Automatic maximum entropy spectral reconstruction in NMR. Journal of Biomolecular NMR, 39 (2), 133-139. doi: 10.1007/s10858-007-9180-8

An automated tool for maximum entropy reconstruction of biomolecular NMR spectra

Mobli, Mehdi, Maciejewski, Mark W., Gryk, Michael R. and Hoch, Jeffrey C. (2007). An automated tool for maximum entropy reconstruction of biomolecular NMR spectra. Nature Methods, 4 (6), 467-468. doi: 10.1038/nmeth0607-467

N-Acetylated amino sugars: the dependence of NMR 3J(HNH2)-couplings on conformation, dynamics and solvent

Mobli, Mehdi and Almond, Andrew (2007). N-Acetylated amino sugars: the dependence of NMR 3J(HNH2)-couplings on conformation, dynamics and solvent. Organic and biomolecular chemistry, 5 (14), 2243-2251. doi: 10.1039/b705761j

Spectral reconstruction methods in fast NMR: Reduced dimensionality, random sampling and maximum entropy

Mobli, Mehdi, Stern, Alan S. and Hoch, Jeffrey C. (2006). Spectral reconstruction methods in fast NMR: Reduced dimensionality, random sampling and maximum entropy. Journal of magnetic resonance, 182 (1), 96-105. doi: 10.1016/j.jmr.2006.06.007

Three-Dimensional 13C-Detected CH3-TOCSY Using Selectively Protonated Proteins: Facile Methyl Resonance Assignment and Protein Structure Determination

Jordan, John B., Kovacs, Helena, Wang, Yuefeng, Mobli, Mehdi, Luo, Rensheng, Anklin, Clemens, Hoch, Jeffrey C. and Kriwacki, Richard W. (2006). Three-Dimensional 13C-Detected CH3-TOCSY Using Selectively Protonated Proteins: Facile Methyl Resonance Assignment and Protein Structure Determination. Journal of the American Chemical Society, 128 (28), 9119-9128. doi: 10.1021/ja058587a

Conformational analysis, Part 41. A modelling and LIS/NMR investigation of the conformations of ,alpa and beta -unsaturated carbonyl compounds

Abraham, Raymond J., Mobli, Mehdi, Ratti, Joyce, Sancassan, Fernando and Smith, Timothy A. D. (2006). Conformational analysis, Part 41. A modelling and LIS/NMR investigation of the conformations of ,alpa and beta -unsaturated carbonyl compounds. Journal of physical organic chemistry, 19 (6), 384-392. doi: 10.1002/poc.1092

Quantum vs. classical models of the nitro group for proton chemical shift calculations and conformational analysis

Mobli, Mehdi and Abraham, Raymond J. (2005). Quantum vs. classical models of the nitro group for proton chemical shift calculations and conformational analysis. Journal of Computational Chemistry, 26 (4), 389-398. doi: 10.1002/jcc.20177

H chemical shifts in NMR. Part 21 - Prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation

Abraham, Raymond J., Bardsley, Ben, Mobli, Mehdi and Smith, Richard J. (2005). H chemical shifts in NMR. Part 21 - Prediction of the 1H chemical shifts of molecules containing the ester group: a modelling and ab initio investigation. Magnetic Resonance in Chemistry, 43 (1), 3-15. doi: 10.1002/mrc.1491

The prediction of 1H NMR chemical shifts in organic compounds

Abraham, Raymond J. and Mobli, Mehdi (2004). The prediction of 1H NMR chemical shifts in organic compounds. Spectroscopy Europe, 16 (4)

1H chemical shifts in NMR. Part 20 - Anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation

Abraham, Raymond J., Mobli, Mehdi and Smith, Richard J. (2004). 1H chemical shifts in NMR. Part 20 - Anisotropic and steric effects in halogen substituent chemical shifts (SCS), a modelling and ab initio investigation. Magnetic resonance in chemistry, 42 (5), 436-444. doi: 10.1002/mrc.1369

1H chemical shifts in NMR: Part 19. Carbonyl anisotropies and steric effects in aromatic aldehydes and ketones

Abraham, Raymond J., Mobli, Medhi and Smith, Richard J. (2003). 1H chemical shifts in NMR: Part 19. Carbonyl anisotropies and steric effects in aromatic aldehydes and ketones. Magnetic Resonance in Chemistry, 41 (1), 26-36. doi: 10.1002/mrc.1125

Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models

Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247

Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein

Franke, B., James, A., Mobli, M., Mylne, J. S. and Rosengren, K. J. (2016). Structural Features of An Unusual Sun-Flower Proalbumin Protein That Gives Rise to a Small Cyclic Peptide and a Seed Storage Protein. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. HOBOKEN: Wiley.

Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design

Schroeder, Christina, Henriques, Sonia, Mobli, Mehdi, Chaousis, Stephanie, Walsh, Phillip, Thongyoo, Panumart and Craik, David (2015). Delineating toxin:lipid:ion channel interactions for rationally sodium channel inhibitors design. 29th Annual Symposium of the Protein Society, Barcelona Spain, Jul 22-25, 2015. Hoboken, United States: Wiley-Blackwell Publishing. doi: 10.1002/pro.2823

Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker

Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.

PX family proteins at the interface between intracellular trafficking and signalling

Ghai, R., Mobli, M., Norwood, S. J., Bugarcic, A., Teasdale, R. D., King, G. F. and Collins, B. M. (2012). PX family proteins at the interface between intracellular trafficking and signalling. 22nd IUBMB Congress/37th FEBS Congress, Seville, Spain, 4-9 September 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/j.1742-4658.2010.08705.x

Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain

Klint, Julie, Anangi, Raveendra, Mobli, Mehdi, Knapp, Oliver, Adams, David J. and King, Glenn F. (2012). Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.032

Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins

Dantas de Araujo, A. D., Herzig, V., Mobli, M., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. F. (2010). Understanding the role of the unusual constrained eight-membered disulfide ring of spider toxins. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.1303

Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR

Mobli, M., Lambert, L. K., Pierens, G. K., Dantas de Araujo, A., Alewood, P. F. and King, G. F. (2008). Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR. 7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008), Couran Cove, Australia, 7-11 December 2008.

Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula (Table S1)

Hardy, Margaret, Daly, Norelle L., Mobli, Mehdi , Morales, Rodrigo and King, Glenn F (2013). Isolation of an orally active insecticidal toxin from the venom of an Australian tarantula (Table S1). Figshare. (Dataset) doi: 10.1371/journal.pone.0073136.s001