The University of Queensland

Analysis of food toxins and toxicants

Wong, Yiu‐chung and Lewis, Richard J eds. (2017). Analysis of food toxins and toxicants. Chichester, West Sussex, United Kingdom: Wiley Blackwell. doi: 10.1002/9781118992685

Pharmacology and structure-function of venom peptide inhibitors of N-type (Cav2.2) calcium channels

Hasan, Md. Mahadhi, Adams, David J. and Lewis, Richard J. (2022). Pharmacology and structure-function of venom peptide inhibitors of N-type (Cav2.2) calcium channels. Voltage-gated calcium channels. (pp. 675-685) edited by Gerald Werner Zamponi and Norbert Weiss. Cham, Switzerland: Springer . doi: 10.1007/978-3-031-08881-0_26

Ciguatoxin detection methods and high-throughput assays

Inserra, Marco, Lavrukhina, Yelena, Jones, Alun, Lewis, Richard J. and Vetter, Irina (2017). Ciguatoxin detection methods and high-throughput assays. Analysis of food toxins and toxicants. (pp. 469-487) edited by Yiu-Chung Wong and Richard J. Lewis. Oxford, United Kingdom: Wiley Blackwell. doi: 10.1002/9781118992685.ch15

Ciguatoxin and ciguatera

Lewis, Richard J. and Vetter, Irina (2016). Ciguatoxin and ciguatera. Marine and freshwater toxins. (pp. 71-92) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_13

Phyla Molluska: the venom apparatus of cone snails

Dutertre, Sebastien, Griffin, John and Lewis, Richard J. (2016). Phyla Molluska: the venom apparatus of cone snails. Marine and freshwater toxins. (pp. 327-340) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_8

Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms

Lewis, Richard J. (2015). Case Study 1: Development of the Analgesic Drugs Prialt (R) and Xen2174 from Cone Snail Venoms. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 245-254) edited by Glenn F. King. Cambridge, United States: RSC. doi: 10.1039/9781849737876-00245

Does nature do ion channel drug discovery better than us?

Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297

Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches

Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F. and King, Glenn F. (2015). Venoms-Based Drug Discovery: Proteomic and Transcriptomic Approaches. Venoms to Drugs. (pp. 80-96) edited by King, Glenn F. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00080

Ciguatera toxins: pharmacology, toxicology and detection

Vetter, Irina, Zimmermann, Katharina and Lewis, Richard J. (2014). Ciguatera toxins: pharmacology, toxicology and detection. Seafood and freshwater toxins: pharmacology, physiology, and detection. (pp. 925-950) edited by Luis M. Botana. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16662-32

Dinoflagellate Toxins: An Overview

Holmes, Michael J., Brust, Andreas and Lewis, Richard J. (2014). Dinoflagellate Toxins: An Overview. Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection. (pp. 3-38) CRC Press. doi: 10.1201/b16662-1

Outstanding marine biotoxins: STX, TTX, and CTX

Amade, Philippe, Mehiri, Mohamed and Lewis, Richard J. (2014). Outstanding marine biotoxins: STX, TTX, and CTX. Outstanding marine molecules: chemistry, biology, analysis. (pp. 23-44) edited by Stéphane La Barre and Jean-Michel Kornprobst. Weinheim, Germany: Wiley Blackwell. doi: 10.1002/9783527681501.ch02

Peptide therapeutics from venomous creatures

Lavergne, Vincent, King, Glenn F., Lewis, Richard J. and Alewood, Paul F. (2014). Peptide therapeutics from venomous creatures. Pain therapeutics: current and future treatment paradigms. (pp. 217-246) edited by Charlotte Allerton. London, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737715-00217

Toxicology of ciguatoxins

Vetter, I. and Lewis, R. J. (2014). Toxicology of ciguatoxins. Toxins and biologically active compounds from microalgae: Volume 2: biological effects and risk management. (pp. xx-xx) Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16806-17

Cone snail biology, bioprospecting and conservation

Dutertre, Sebastien and Lewis, Richard J. (2013). Cone snail biology, bioprospecting and conservation. Snails: biology, ecology and conservation. (pp. 85-104) edited by Emil M. Hämäläinen and Sofia Järvinen. New York, NY, United States: Nova Science Publishers.

Voltage-gated sodium channels as therapeutic targets.

Wingerd, Joshua S., Vetter, Irina and Lewis, Richard J. (2012). Voltage-gated sodium channels as therapeutic targets.. Therapeutic targets: Modulation, Inhibition and Activation.. (pp. 63-122) edited by Luis M. Botana and Mabel Loza. Hoboken NJ, United States: John Wiley and Sons.

Natural product ligands of TRP channels

Vetter, Irina and Lewis, Richard J. (2011). Natural product ligands of TRP channels. Transient receptor potential channels. (pp. 41-85) edited by Md. Shahidul Islam. New York, United States: Springer. doi: 10.1007/978-94-007-0265-3_3

Conotoxins: molecular and therapeutic targets

Lewis, R. J. (2009). Conotoxins: molecular and therapeutic targets. Marine toxins as research tools (Progress in Molecular and Subcellular Biology). (pp. 45-66) edited by N. Fusetani. Berlin: Springer Verlag.

Block of voltage-gated calcium channels by peptide toxins

Schroeder, C. I., Lewis, R. J. and Adams, D. J. (2005). Block of voltage-gated calcium channels by peptide toxins. Voltage-Gated Calcium Channels. (pp. 294-308) edited by Gerald W. Zamponi. New York, U.S.A.: Springer US. doi: 10.1007/0-387-27526-6_19

Detection of toxins associated with cigutera fish poisoning

Lewis, R. J. (2003). Detection of toxins associated with cigutera fish poisoning. Manual on Harmful Marine Microalgae. (pp. 267-277) edited by Hallegraeff, G M; Anderson, D M; Cembella and A D. Landais, France: UNESCO Publishing.

Toxin-producting dinoflagellates

Holmes, M.J. and Lewis, R. J. (2002). Toxin-producting dinoflagellates. Perspectives in Molecular Toxinology. (pp. 39-65) edited by Andre Menez. England: John Wiley & sons Ltd.

Ciguatera (fish poisoning)

Fenner, P. and Lewis, R. J. (2001). Ciguatera (fish poisoning). Channelopathies of the nervous sytstem. (pp. 295-307) edited by Michael Rose and Robert C. Griggs. USA: Butterworth Heinemann.

Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings

Lewis, Richard J., Molgo, Jordi and Adams, David J. (2000). Ciguatera toxins: Pharmacology of toxins involved in Ciguatera and related fish poisonings. Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection. (pp. 419-447) edited by Luis M. Botana. New York: Marcel Dekker Inc..

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain

Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain. International Journal of Molecular Sciences, 25 (9), 4745. doi: 10.3390/ijms25094745

Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2023). Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes. Frontiers in Pharmacology, 14 1277143, 1277143. doi: 10.3389/fphar.2023.1277143

Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples

Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J. and Gruber, Christian W. (2023). Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. Journal of Medicinal Chemistry, 66 (17), 11843-11854. doi: 10.1021/acs.jmedchem.3c00426

Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety

Pottier, Ivannah, Lewis, Richard J. and Vernoux, Jean-Paul (2023). Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety. Toxins, 15 (7) 453, 1-40. doi: 10.3390/toxins15070453

Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail

Rogalski, Aymeric, Himaya, S. W. A. and Lewis, Richard J. (2023). Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail. Nature Communications, 14 (1) 3287, 1-11. doi: 10.1038/s41467-023-38924-5

The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli

Grundy, Luke, Tay, Cindy, Christie, Stewart, Harrington, Andrea M., Castro, Joel, Cardoso, Fernanda C., Lewis, Richard J., Zagorodnyuk, Vladimir and Brierley, Stuart M. (2023). The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164 (5), 1012-1026. doi: 10.1097/j.pain.0000000000002795

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

Ho, Thao NT, Abraham, Nikita and Lewis, Richard J. (2023). Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors. Frontiers in Pharmacology, 14 1170514, 1170514. doi: 10.3389/fphar.2023.1170514

Model of the origin of a ciguatoxic grouper (Plectropomus leopardus)

Holmes, Michael J. and Lewis, Richard J. (2023). Model of the origin of a ciguatoxic grouper (Plectropomus leopardus). Toxins, 15 (3) 230, 1-20. doi: 10.3390/toxins15030230

"Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022)

Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Koenig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2023). "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022). Journal of Medicinal Chemistry, 66 (3), 2204-2204. doi: 10.1021/acs.jmedchem.3c00037

Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1)

Holmes, Michael J. and Lewis, Richard J. (2022). Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1). Toxins, 14 (11) 767, 1-8. doi: 10.3390/toxins14110767

The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders

Cardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077

Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2022). Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. RSC Medicinal Chemistry, 13 (11), 1410-1419. doi: 10.1039/d2md00188h

Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain

Holmes, Michael J. and Lewis, Richard J. (2022). Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain. Toxins, 14 (8) 534, 1-11. doi: 10.3390/toxins14080534

Diindolylmethane derivatives: new selective blockers for T-type calcium channels

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749

The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF ^V600E

Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923

Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents

Mattei, César, Tricoire-Leignel, Hélène, Legros, Christian, Lewis, Richard J. and Molgó, Jordi (2022). Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents. Frontiers in Neuroscience, 16 895299, 895299. doi: 10.3389/fnins.2022.895299

Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor

Wilhelm, Patrick, Luna-Ramirez, Karen, Chin, Yanni K.-Y., Dekan, Zoltan, Abraham, Nikita, Tae, Han-Shen, Chow, Chun Yuen, Eagles, David A., King, Glenn F., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2022). Cysteine-rich α-conotoxin SII displays novel interactions at the muscle nicotinic acetylcholine receptor. ACS Chemical Neuroscience, 13 (8), 1245-1250. doi: 10.1021/acschemneuro.1c00857

Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans

Prashanth, Jutty Rajan, Dutertre, Sebastien, Rai, Subash Kumar and Lewis, Richard J. (2022). Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans. Toxins, 14 (3) 226, 226. doi: 10.3390/toxins14030226

Comparative venomics of C. flavidus and C. frigidus and closely related vermivorous cone snails

Himaya, S. W. A., Arkhipov, Alexander, Yum, Wai Ying and Lewis, Richard J. (2022). Comparative venomics of C. flavidus and C. frigidus and closely related vermivorous cone snails. Marine Drugs, 20 (3) 209, 209. doi: 10.3390/md20030209

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction

Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Konig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2022). Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. Journal of Medicinal Chemistry, 65 (4), 3473-3517. doi: 10.1021/acs.jmedchem.1c01975

Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain

Cardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2022). Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain. RSC Medicinal Chemistry, 13 (2), 183-195. doi: 10.1039/d1md00331c

Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid

Dongol, Yashad, Choi, Phil M., Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid. Frontiers in Pharmacology, 12 795455, 795455. doi: 10.3389/fphar.2021.795455

Unique pharmacological properties of α-Conotoxin OmIA at α7 nAChRs

Ho, Thao N.T., Abraham, Nikita and Lewis, Richard J. (2021). Unique pharmacological properties of α-Conotoxin OmIA at α7 nAChRs. Frontiers in Pharmacology, 12 803397, 803397. doi: 10.3389/fphar.2021.803397

Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus

Himaya, S. W.A., Jin, Ai-Hua, Hamilton, Brett, Rai, Subash K., Alewood, Paul and Lewis, Richard J. (2021). Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus. Scientific Reports, 11 (1) 13282, 13282. doi: 10.1038/s41598-021-91919-4

Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2021). Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA. Scientific Reports, 11 (1) 21928, 21928. doi: 10.1038/s41598-021-01277-4

Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo

Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457

Critical review and conceptual and quantitative models for the transfer and depuration of ciguatoxins in fishes

Holmes, Michael J., Venables, Bill and Lewis, Richard J. (2021). Critical review and conceptual and quantitative models for the transfer and depuration of ciguatoxins in fishes. Toxins, 13 (8) 515, 1-57. doi: 10.3390/toxins13080515

Pacific-ciguatoxin-2 and brevetoxin-1 induce the sensitization of sensory receptors mediating pain and pruritus in sensory neurons

Pierre, Ophélie, Fouchard, Maxime, Le Goux, Nelig, Buscaglia, Paul, Leschiera, Raphaël, Lewis, Richard J., Mignen, Olivier, Fluhr, Joachim W., Misery, Laurent and Le Garrec, Raphaële (2021). Pacific-ciguatoxin-2 and brevetoxin-1 induce the sensitization of sensory receptors mediating pain and pruritus in sensory neurons. Marine Drugs, 19 (7) 387, 1-19. doi: 10.3390/md19070387

Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain

Hasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645

Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy

Hasan, Md. Mahadhi, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy. Marine Drugs, 19 (2) 106, 1-15. doi: 10.3390/md19020106

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041

Chemical synthesis and NMR solution structure of conotoxin GXIA from Conus geographus

Armstrong, David A., Jin, Ai-Hua, Braga Emidio, Nayara, Lewis, Richard J., Alewood, Paul F. and Rosengren, K. Johan (2021). Chemical synthesis and NMR solution structure of conotoxin GXIA from Conus geographus. Marine Drugs, 19 (2) 60, 1-14. doi: 10.3390/md19020060

Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits

Nevin, S. T., Lawrence, N., Nicke, A., Lewis, R. J. and Adams, D. J. (2021). Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits. Channels, 15 (1), 79-93. doi: 10.1080/19336950.2020.1860399

Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding

Ho, Thao N. T., Lee, Han Siean, Swaminathan, Shilpa, Goodwin, Lewis, Rai, Nishant, Ushay, Brianna, Lewis, Richard J., Rosengren, K. Johan and Conibear, Anne C. (2021). Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Medicinal Chemistry, 12 (9), 1574-1584. doi: 10.1039/d1md00182e

Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2020). Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins. Frontiers in Neuroscience, 14 609005, 1-23. doi: 10.3389/fnins.2020.609005

Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor

McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

Herzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117

The neuronal calcium ion channel activity of constrained analogues of MONIRO-1

Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655

PAR2, keratinocytes, and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning

L’Herondelle, Killian, Pierre, Ophelie, Fouyet, Sophie, Leschiera, Raphael, Le Gall-Ianotto, Christelle, Philippe, Reginald, Buscaglia, Paul, Mignen, Olivier, Talagas, Matthieu, Lewis, Richard J., Michel, Laurence, Misery, Laurent and Le Garrec, Raphaele (2020). PAR2, keratinocytes, and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning. Journal of Investigative Dermatology, 141 (3), 648-658.e3. doi: 10.1016/j.jid.2020.07.020

Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator

Wang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343

Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors

Mohan, Madhan Kumar, Abraham, Nikita, Rajesh, R. P., Jayaseelan, Benjamin Franklin, Ragnarsson, Lotten, Lewis, Richard J. and Sarma, Siddhartha P. (2020). Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295 (20), 7096-7112. doi: 10.1074/jbc.RA119.012098

In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile

Kuo, Andy, Magiera, Julia, Rethwan, Nursyazwani, Andersson, Åsa, Leen Lam, Ai, Wyse, Bruce, Meutermans, Wim, Lewis, Richard and Smith, Maree (2020). In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology, 872 172947, 172947. doi: 10.1016/j.ejphar.2020.172947

Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris

Giribaldi, Julien, Ragnarsson, Lotten, Pujante, Tom, Enjalbal, Christine, Wilson, David, Daly, Norelle L., Lewis, Richard J. and Dutertre, Sebastien (2020). Synthesis, pharmacological and structural characterization of novel conopressins from Conus miliaris. Marine Drugs, 18 (3) md18030150, 150. doi: 10.3390/md18030150

Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter

Jha, Prerna, Ragnarsson, Lotten and Lewis, Richard J. (2020). Structure-function of the high affinity substrate binding site (S1) of human norepinephrine transporter. Frontiers in Pharmacology, 11 217, 217. doi: 10.3389/fphar.2020.00217

The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein

Scheib, Holger, Nekaris, K. Anne-Isola, Rode-Margono, Johanna, Ragnarsson, Lotten, Baumann, Kate, Dobson, James S., Wirdateti, Wirdateti, Nouwens, Amanda, Nijman, Vincent, Martelli, Paolo, Ma, Rui, Lewis, Richard J., Kwok, Hang Fai and Fry, Bryan Grieg (2020). The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein. Toxins, 12 (2) toxins12020086, 86. doi: 10.3390/toxins12020086

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7

Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080

Venomic interrogation reveals the complexity of Conus striolatus venom

Himaya, S.W.A., Rai, Subash K., Pamfili, Giulia, Jin, Ai-Hua, Alewood, Paul F. and Lewis, Richard J. (2020). Venomic interrogation reveals the complexity of Conus striolatus venom. Australian Journal of Chemistry, 73 (4), 357-365. doi: 10.1071/ch19588

Structural basis for the coordination of cell division with the synthesis of the bacterial cell envelope

Booth, Simon and Lewis, Richard J. (2019). Structural basis for the coordination of cell division with the synthesis of the bacterial cell envelope. Protein Science, 28 (12), 2042-2054. doi: 10.1002/pro.3722

The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Åsa, Brust, Andreas, Dekan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2019). The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports, 9 (1) 17841, 17841. doi: 10.1038/s41598-019-54186-y

Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways

Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626

Conotoxins: chemistry and biology

Jin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019). Conotoxins: chemistry and biology. Chemical Reviews, 119 (21), 11510-11549. doi: 10.1021/acs.chemrev.9b00207

Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis

Ferraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218

Structural basis for interaction of DivIVA/GpsB proteins with their ligands

Halbedel, Sven and Lewis, Richard J. (2019). Structural basis for interaction of DivIVA/GpsB proteins with their ligands. Molecular Microbiology, 111 (6), 1404-1415. doi: 10.1111/mmi.14244

Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels

Cardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025

Transcriptomic-proteomic correlation in the predation-evoked venom of the cone snail, Conus imperialis

Jin, Ai-Hua, Dutertre, Sébastien, Dutt, Mriga, Lavergne, Vincent, Jones, Alun, Lewis, Richard and Alewood, Paul (2019). Transcriptomic-proteomic correlation in the predation-evoked venom of the cone snail, Conus imperialis. Marine Drugs, 17 (3) 177, 177. doi: 10.3390/md17030177

‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

Ziegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165

Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485

Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa

Dutt, Mriga, Dutertre, Sébastien, Jin, Ai-Hua, Lavergne, Vincent, Alewood, Paul and Lewis, Richard (2019). Venomics reveals venom complexity of the piscivorous cone snail, Conus tulipa. Marine Drugs, 17 (1) 71, 71. doi: 10.3390/md17010071

Insight into T-type calcium channel structure, function and modulation

Wang, Dan, Ragnarsson, Lotten and Lewis, Richard J. (2019). Insight into T-type calcium channel structure, function and modulation. Current medicinal chemistry, 27 (19), 3098-3122. doi: 10.2174/0929867325666181001112821

On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe

Muttenthaler, Markus, Nevin, Simon T., Inserra, Marco, Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2019). On-resin strategy to label α-Conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry, 73 (4), 327-333. doi: 10.1071/CH19456

Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia

Larsson, Michaela E., Harwood, Tim D., Lewis, Richard J., S. W. A., Himaya and Doblin, Martina A. (2019). Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia. Phycological Research, 67 (1), 65-71. doi: 10.1111/pre.12349

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert J. and Lewis, Richard J. (2018). Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs, 16 (12) 475, 475. doi: 10.3390/md16120475

Transcriptomics in pain research: insights from new and old technologies

Starobova, H., S. W. A., Himaya, Lewis, R. J. and Vetter, I. (2018). Transcriptomics in pain research: insights from new and old technologies. Molecular Omics, 14 (6), 389-404. doi: 10.1039/c8mo00181b

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4

The hidden lipoproteome of Staphylococcus aureus

Graf, Anica, Lewis, Richard J., Fuchs, Stephan, Pagels, Martin, Engelmann, Susanne, Riedel, Katharina and Pané-Farré, Jan (2018). The hidden lipoproteome of Staphylococcus aureus. International Journal of Medical Microbiology, 308 (6), 569-581. doi: 10.1016/j.ijmm.2018.01.008

Inhibition of somatosensory mechanotransduction by annexin A6

Raouf, Ramin, Lolignier, Stéphane, Sexton, Jane E., Millet, Queensta, Santana-Varela, Sonia, Biller, Anna, Fuller, Alice M., Pereira, Vanessa, Choudhary, Jyoti S., Collins, Mark O., Moss, Stephen E., Lewis, Richard, Tordo, Julie, Henckaerts, Els, Linden, Michael and Wood, John N. (2018). Inhibition of somatosensory mechanotransduction by annexin A6. Science Signaling, 11 (535) eaao2060, eaao2060. doi: 10.1126/scisignal.aao2060

Neuronal nicotinic acetylcholine receptor modulators from cone snails

Abraham, Nikita and Lewis, Richard J. (2018). Neuronal nicotinic acetylcholine receptor modulators from cone snails. Marine Drugs, 16 (6) 208;, 208. doi: 10.3390/md16060208

Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660)

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2018). Corrigendum to: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter (Angewandte Chemie International Edition, (2013), 52, 46, (12020-12023), 10.1002/anie.201304660). Angewandte Chemie - International Edition, 57 (19), 5203-5203. doi: 10.1002/anie.201803138

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Slagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018). Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148, 213-222. doi: 10.1016/j.toxicon.2018.04.022

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels

Sairaman, Anjali, Cardoso, Fernanda Caldas, Bispat, Anjie, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2018). Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic and Medicinal Chemistry, 26 (11), 3046-3059. doi: 10.1016/j.bmc.2018.03.031

Venomics-accelerated cone snail venom peptide discovery

Himaya, S. W. A. and Lewis, Richard J. (2018). Venomics-accelerated cone snail venom peptide discovery. International Journal of Molecular Sciences, 19 (3) 788, 788. doi: 10.3390/ijms19030788

Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides

Stefanucci, Azzurra, Novelino, Ettore, Macedonio, Giorgia, Dimmito, Marilia Pia, Mirzaie, Sako, Cardoso, Fernanda Caldas , Lewis, Richard, Zador, Ferenc, Erdei, Anna I., Dvoracsko, Szabolcs, Tomboly, Csaba, Benych, Sandor, Pieretti, Stefano, Minosi, Paola and Mollica, Adriano (2018). Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42 (8), 5656-5659. doi: 10.1039/c7nj04969b

Toxins in pain

Cardoso, Fernanda C., Hasan, Mahadhi, Zhao, Tianjiao and Lewis, Richard J. (2018). Toxins in pain. Current Opinion in Supportive and Palliative Care, 12 (2), 1-10. doi: 10.1097/SPC.0000000000000335

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain

Morgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016

Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals

Himaya, S W A, Marí, Frank and Lewis, Richard J (2018). Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. Scientific reports, 8 (1) 330, 1-8. doi: 10.1038/s41598-017-17422-x

Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters

Larsson, Michaela E., Laczka, Olivier F., Harwood, D. Tim, Lewis, Richard J., Himaya, S. W. A., Murray, Shauna A. and Doblin, Martina A. (2018). Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters. Marine Drugs, 16 (1) 7, 1-19. doi: 10.3390/md16010007

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398

Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie, 129 (47), 15169-15172. doi: 10.1002/ange.201708927

Neuropharmacology of venom peptides

Adams, David J. and Lewis, Richard J. (2017). Neuropharmacology of venom peptides. Neuropharmacology, 127, 1-3. doi: 10.1016/j.neuropharm.2017.11.025

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity. Angewandte Chemie (International ed. in English), 56 (47), 14973-14976. doi: 10.1002/anie.201708927

Pharmacology of predatory and defensive venom peptides in cone snails

Prashanth, Jutty Rajan, Dutertre, Sebastien and Lewis, Richard James (2017). Pharmacology of predatory and defensive venom peptides in cone snails. Molecular bioSystems, 13 (12), 2453-2465. doi: 10.1039/c7mb00511c

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848

Ciguatoxins evoke potent CGRP release by activation of voltage-gated sodium channel subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1

Touska, Filip, Sattler, Simon, Malsch, Philipp, Lewis, Richard J., Reeh, Peter W. and Zimmermann, Katharina (2017). Ciguatoxins evoke potent CGRP release by activation of voltage-gated sodium channel subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1. Marine Drugs, 15 (9) 269, 269. doi: 10.3390/md15090269

Sodium channels and pain: from toxins to therapies

Cardoso, Fernanda Caldas and Lewis, Richard J. (2017). Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology, 175 (12), 2138-2157. doi: 10.1111/bph.13962

Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1

McArthur, Jeffrey R., Motin, Leonid, Gleeson, Ellen C., Spiller, Sandro, Lewis, Richard J., Duggan, Peter J., Tuck, Kellie L. and Adams, David J. (2017). Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British Journal of Pharmacology, 175 (12), 2284-2295. doi: 10.1111/bph.13910

Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883)

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus

Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865

The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography

Asberg, Dennis, Weinmann, Annika Langborg, Leek, Tomas, Lewis, Richard J., Klarqvist, Magnus, Lesko, Marek, Kaczmarski, Krzysztof, Samuelsson, Jorgen and Fornstedt, Torgny (2017). The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography. Journal of Chromatography a, 1496, 80-91. doi: 10.1016/j.chroma.2017.03.041

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors

Windley, Monique J., Vetter, Irina, Lewis, Richard J. and Nicholson, Graham M. (2017). Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology, 127, 224-242. doi: 10.1016/j.neuropharm.2017.04.008

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

Abraham, Nikita, Healy, Michael, Ragnarsson, Lotten, Brust, Andreas, Alewood, Paul F. and Lewis, Richard J. (2017). Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports, 7 (1) 45466, 45466. doi: 10.1038/srep45466

Revising the Role of Defense and Predation in Cone Snail Venom Evolution

Prashanth, Jutty Rajan, Dutertre, Sebastien and Lewis, Richard James (2017). Revising the Role of Defense and Predation in Cone Snail Venom Evolution. Evolution of Venomous Animals and Their Toxins, 105-123. doi: 10.1007/978-94-007-6458-3_18

The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant

Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810

Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses

Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883

Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin

Eisenblatter, Anneka, Lewis, Richard, Dorfler, Arnd, Forster, Clemens and Zimmermann, Katharina (2017). Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin. Annals of Neurology, 81 (1), 104-116. doi: 10.1002/ana.24841

Structural and conformational determinants of macrocycle cell permeability

Over, Bjorn, Matsson, Par, Tyrchan, Christian, Artursson, Per, Doak, Bradley C., Foley, Michael A., Hilgendorf, Constanze, Johnston, Stephen E., Lee, Maurice D., Lewis, Richard J., McCarren, Patrick, Muncipinto, Giovanni, Norinder, Ulf, Perry, Matthew W. D., Duvall, Jeremy R. and Kihlberg, Jan (2016). Structural and conformational determinants of macrocycle cell permeability. Nature Chemical Biology, 12 (12), 1065-+. doi: 10.1038/NCHEMBIO.2203

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia

Bressan, Elisangela, Touska, Filip, Vetter, Irina, Kistner, Katrin, Kichko, Tatjana I., Teixeira, Nathalia B., Picolo, Gisele, Cury, Yara, Lewis, Richard J., Fischer, Michael J. M., Zimmermann, Katharina and Reeh, Peter W. (2016). Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, 157 (11), 2504-2516. doi: 10.1097/j.pain.0000000000000669

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366

Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay

Lewis, Richard J., Inserra, Marco, Vetter, Irina, Holland, William C., Hardison, D. Ransom, Tester, Patricia A. and Litaker, R. Wayne (2016). Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay. PLoS ONE, 11 (7) e0160006, e0160006. doi: 10.1371/journal.pone.0160006

Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs)

Abraham, Nikita, Paul, Blessy, Ragnarsson, Lotten and Lewis, Richard J. (2016). Escherichia coli protein expression system for Acetylcholine Binding Proteins (AChBPs). PLoS One, 11 (6) e0157363, e0157363. doi: 10.1371/journal.pone.0157363

Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins

Le Garrec, Raphaele, L'herondelle, Killian, Le Gall-Ianotto, Christelle, Lebonvallet, Nicolas, Leschiera, Raphael, Buhe, Virginie, Talagas, Matthieu, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2016). Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon, 116, 4-10. doi: 10.1016/j.toxicon.2015.11.004

Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8

Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

Wan, Jingjing, Brust, Andreas, Bhola, Rebecca F., Jha, Prerna, Mobli, Mehdi, Lewis, Richard J., Christie, Macdonald J. and Alewood, Paul F. (2016). Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science, 22 (5), 280-289. doi: 10.1002/psc.2857

Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties

Brust, Andreas, Croker, Daniel, Colless, Barbara, Ragnarsson, Lotten K. N., Andersson, Asa, Jain, Kapil, Garcia-Caraballo, Sonia, Castro, Joel, Brierley, Stuart M., Alewood, Paul F. and Lewis, Richard J. (2016). Conopeptide-derived κ-opioid agonists (conorphins): potent, selective, and metabolic stable dynorphin a mimetics with antinociceptive properties. Journal of Medicinal Chemistry, 59 (6), 2381-2395. doi: 10.1021/acs.jmedchem.5b00911

Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain

Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078

Ionic mechanisms of spinal neuronal cold hypersensitivity in Ciguatera

Patel, Ryan, Brice, Nicola L., Lewis, Richard J. and Dickenson, Anthony H. (2015). Ionic mechanisms of spinal neuronal cold hypersensitivity in Ciguatera. European Journal of Neuroscience, 42 (11), 3004-3011. doi: 10.1111/ejn.13098

The role of defensive ecological interactions in the evolution of conotoxins

Prashanth, J. R., Dutertre, S., Jin, A. H., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2015). The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology, 25 (2), 598-615. doi: 10.1111/mec.13504

Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia

Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus

Himaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015). Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 (10), 4372-4381. doi: 10.1021/acs.jproteome.5b00630

An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation

Prashanth, Jutty Rajan and Lewis, Richard J. (2015). An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation. Toxicon, 107 (Pt B), 282-289. doi: 10.1016/j.toxicon.2015.09.012

Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens

Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015). δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 (1811) 20150817, 1-8. doi: 10.1098/rspb.2015.0817

Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS

Rodriguez, Alena M., Dutertre, Sebastian, Lewis, Richard J. and Mari, Frank (2015). Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS. Analytical and Bioanalytical Chemistry, 407 (20), 6105-6116. doi: 10.1007/s00216-015-8787-y

Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach

Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081

Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives

Gleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2015). Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs, 13 (4), 2030-2045. doi: 10.3390/md13042030

α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors

Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011

High-voltage activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury

Murali, Swetha S., Napier, Ian A., Mohammadi, Sarasa A., Alewood, Paul F., Lewis, Richard J. and Christie, MacDonald J. (2015). High-voltage activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology, 113 (5), 1511-1519. doi: 10.1152/jn.00608.2014

Therapeutic opportunities for targeting cold pain pathways

Yin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015). Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 (2), 125-140. doi: 10.1016/j.bcp.2014.09.024

Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2015). Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions. Molecular Pharmacology, 87 (1), 121-129. doi: 10.1124/mol.114.094557

Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic

Gori, Alessandro, Wang, Ching-I A., Harvey, Peta J., Rosengren, K. Johan, Bhola, Rebecca F., Gelmi, Maria L., Longhi, Renato, Christie, Macdonald J., Lewis, Richard J., Alewood, Paul F. and Brust, Andreas (2015). Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic. Angewandte Chemie - International Edition, 54 (4), 1361-1364. doi: 10.1002/anie.201409678

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom

Jin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015). Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 (23-24), 4030-4040. doi: 10.1002/pmic.201500220

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors

Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244

Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands

Mollica, Adriano, Costante, Roberto, Novellino, Ettore, Stefanucci, Azzurra, Pieretti, Stefano, Zador, Ferenc, Samavati, Reza, Borsodi, Anna, Benyhe, Sandor, Vetter, Irina and Lewis, Richard J. (2014). Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands. Chemical Biology and Drug Design, 86 (2), 156-162. doi: 10.1111/cbdd.12479

Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose

Dutertre, Sebastien, Jin, Ai-Hua, Alewood, Paul F. and Lewis, Richard J. (2014). Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose. Toxicon, 91, 135-144. doi: 10.1016/j.toxicon.2014.09.011

Structure and function of a spectrin-like regulator of bacterial cytokinesis

Cleverley, Robert M., Barrett, Jeffrey R., Baslé, Arnaud, Bui, Nhat Khai, Hewitt, Lorraine, Solovyova, Alexandra, Xu, Zhi-Qiang, Daniel, Richard A., Dixon, Nicholas E., Harry, Elizabeth J., Oakley, Aaron J., Vollmer, Waldemar and Lewis, Richard J. (2014). Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications, 5 (1) 5421. doi: 10.1038/ncomms6421

Cone snail venomics: From novel biology to novel therapeutics

Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sebastien and Lewis, Richard J. (2014). Cone snail venomics: From novel biology to novel therapeutics. Future Medicinal Chemistry, 6 (15), 1659-1675. doi: 10.4155/FMC.14.99

2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.

Karas, John A., Scanlon, Denis B., Forbes, Briony E., Vetter, Irina, Lewis, Richard J., Gardiner, James, Separovic, Frances, Wade, John D. and Hossain, Mohammed A. (2014). 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.. Chemistry: A European Journal, 20 (31), 9549-9552. doi: 10.1002/chem.201403574

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

Wang, Ching-I Anderson, Reeks, Timothy, Vetter, Irina, Vergara, Irene, Kovtun, Oleksiy, Lewis, Richard J., Alewood, Paul F. and Durek, Thomas (2014). Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry, 53 (23), 3758-3766. doi: 10.1021/bi5004475

Discovery, synthesis, and structure: activity relationships of conotoxins

Akondi, Kalyana, Muttenthaler, Markus, Dutertre, Sébastien, Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2014). Discovery, synthesis, and structure: activity relationships of conotoxins. Chemical Reviews, Articles ASAP (11), 1-33. doi: 10.1021/cr400401e

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

Dutertre, Sébastien, Jin, Ai-Hua, Vetter, Irina, Hamilton, Brett, Sunagar, Kartik, Lavergne, Vincent, Dutertre, Valentin, Fry, Bryan G., Antunes, Agostinho, Venter, Deon J., Alewood, Paul F. and Lewis, Richard J. (2014). Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications, 5 (3521) 3521, 1-9. doi: 10.1038/ncomms4521

Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

Heus, Ferry, Otvos, Reka A., Aspers, Ruud L. E. G., van Elk, Rene, Halff, Jenny I., Ehlers, Andreas W., Dutertre, Sébastien, Lewis, Richard J., Wijmenga, Sybren, Smit, August B., Niessen, Wilfried M. A. and Kool, Jeroen (2014). Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. Biology, 3 (1), 139-156. doi: 10.3390/biology3010139

MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors

Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014). MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 (1), 1-3. doi: 10.1021/bi400882s

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin

Deuis, Jennifer R., Lim, Yu Ling, Rodrigues de Sousa, Silmara, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2014). Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology, 16 (10), 1324-1332. doi: 10.1093/neuonc/nou048

Erratum: Cone snail venomics: From novel biology to novel therapeutics (Future Medicinal Chemistry (2014) 6:15 (1659-1675))

Prashanth, Jutty Rajan, Brust, Andreas, Jin, Ai-Hua, Alewood, Paul F., Dutertre, Sébastien and Lewis, Richard J. (2014). Erratum: Cone snail venomics: From novel biology to novel therapeutics (Future Medicinal Chemistry (2014) 6:15 (1659-1675)). Future Medicinal Chemistry, 6 (18). doi: 10.4155/fmc.14.159

Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection

Manger, Ronald, Woodle, Doug, Berger, Andrew, Dickey, Robert W., Jester, Edward, Yasumoto, Takesh, Lewis, Richard, Hawryluk, Timothy and Hungerford, James (2014). Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection. Journal of AOAC International, 97 (2), 299-306. doi: 10.5740/jaoacint.SGEManger

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

Hopping, Gene, Wang, C-I Anderson, Hogg, Ron C., Nevin, Simon T., Lewis, Richard J., Adams, David J. and Alewood, Paul F. (2014). Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology, 91 (4), 534-542. doi: 10.1016/j.bcp.2014.07.025

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165

Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: Changes in community distribution and coastal eutrophication

Skinner, Mark P., Lewis, Richard J. and Morton, Steve (2013). Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: Changes in community distribution and coastal eutrophication. Marine Pollution Bulletin, 77 (1-2), 210-219. doi: 10.1016/j.marpolbul.2013.10.003

Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

Jin, Ai-Hua, Dutertre, Sébastien, Kaas, Quentin, Lavergne, Vincent, Kubala, Petra, Lewis, Richard J. and Alewood, Paul F. (2013). Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular and Cellular Proteomics, 12 (12), 3824-3833. doi: 10.1074/mcp.M113.030353

Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter

Brust, Andreas, Wang, Ching-I. A., Daly, Norelle L., Kennerly, Joe, Sadeghi, Mahsa, Christie, Macdonald J., Lewis, Richard J., Mobli, Mehdi and Alewood, Paul F. (2013). Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Edition), 52 (46), 12020-12023. doi: 10.1002/anie.201304660

Novel omega-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration

Sadeghi, Mahsa, Murali, Swetha S., Lewis, Richard J., Alewood, Paul F., Mohammadi, Sarasa and Christie, MacDonald J. (2013). Novel omega-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain, 9 (1) 51, 51.1-51.8. doi: 10.1186/1744-8069-9-51

Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition

Vetter, Irina, Hein, Alexander, Sattler, Simon, Hessler, Sabine, Touska, Filip, Bressan, Elisangela, Parra, Andres, Hager, Ulrich, Leffler, Andreas, Boukalova, Stepana, Nissen, Matthias, Lewis, Richard J., Belmonte, Carlos, Alzheimer, Christian, Huth, Tobias, Vlachova, Viktorie, Reeh, Peter W. and Zimmermann, Katharina (2013). Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition. Journal of Neuroscience, 33 (42), 16627-16641. doi: 10.1523/JNEUROSCI.1473-13.2013

Analgesic treatment of ciguatoxin-induced cold allodynia

Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies

Lavergne, Vincent, Dutertre, Sebastien, Jin, Ai-hua, Lewis, Richard J., Taft, Ryan J. and Alewood, Paul F. (2013). Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics, 14 (1) 708, 708.1-708.11. doi: 10.1186/1471-2164-14-708

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways

Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032

Isolation and characterization of alpha-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

Inserra, Marco C., Kompella, Shiva N., Vetter, Irina, Brust, Andreas, Daly, Norelle L., Cuny, Hartmut, Craik, David J., Alewood, Paul F., Adams, David J. and Lewis, Richard J. (2013). Isolation and characterization of alpha-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology, 86 (6), 791-799. doi: 10.1016/j.bcp.2013.07.016

Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model

Jayamanne, A., Jeong, H. J., Schroeder, C. I., Lewis, R. J., Christie, M. J. and Vaughan, C. W. (2013). Spinal actions of omega-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology, 170 (2), 245-254. doi: 10.1111/bph.12251

Re-engineering the mu-conotoxin SIIIA scaffold

Akondi, Kalyana B., Lewis, Richard J. and Alewood, Paul F. (2013). Re-engineering the mu-conotoxin SIIIA scaffold. Biopolymers, Accepted Article (4), 1-21. doi: 10.1002/bip.22368

Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1

Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2013). Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. ACS Chemical Biology, 8 (6), 1215-1222. doi: 10.1021/cb400012k

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F. and Dulhunty, Angela F. (2013). Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America, 110 (22), 8906-8911. doi: 10.1073/pnas.1214062110

Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells

Sousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten and Lewis, Richard J. (2013). Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells. PloS One, 8 (3) e59293, e59293. doi: 10.1371/journal.pone.0059293

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Brust, Andreas, Sunagar, Kartik, Eivind Undheim, Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Ruder, Tim, Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2013). Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular and Cellular Proteomics, 12 (3), 651-663. doi: 10.1074/mcp.M112.023135

Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom

Dutertre, Sebastien, Jin, Ai-Hua (Jean), Kaas, Quentin, Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (2013). Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular and Cellular Proteomics, 12 (2), 312-329. doi: 10.1074/mcp.M112.021469

Venom peptides as a rich source of Cav2.2 channel blockers

Sousa, Silmara R., Vetter, Irina and Lewis, Richard J. (2013). Venom peptides as a rich source of Cav2.2 channel blockers. Toxins, 5 (2), 286-314. doi: 10.3390/toxins5020286

Emerging opportunities for allosteric modulation of G-protein coupled receptors

Wang, Ching-I. Anderson and Lewis, Richard J. (2013). Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochemical Pharmacology, 85 (2), 153-162. doi: 10.1016/j.bcp.2012.09.001

Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor

Ragnarsson, Lotten, Wang, Ching-I Anderson, Andersson, Asa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2013). Conopeptide p-tia defines a new allosteric site on the extracellular surface of the α1b-adrenoceptor. Journal of Biological Chemistry, 288 (3), 1814-1827. doi: 10.1074/jbc.M112.430785

Efficient chemical synthesis of human complement protein C3a

Ghassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013). Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 (23), 2356-2358. doi: 10.1039/c3cc40537k

Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013)

Brust, Andreas, Sunagar, Kartik, Undheim, Eivind A. B., Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2012). Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013). Molecular & Cellular Proteomics, 12 (5), 1488-1488. doi: 10.1074/mcp.M112.023135

A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter

Wang, Ching-I A., Shaikh, Nausad H., Ramu, Soumya and Lewis, Richard J. (2012). A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter. Molecular Pharmacology, 82 (5), 898-909. doi: 10.1124/mol.112.080630

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

Vetter, Irina, Touska, Filip, Hess, Andreas, Hinsbey, Rachel, Sattler, Simon, Lampert, Angelika, Sergejeva, Marina, Sharov, Anastasia, Collins, Lindon S., Eberhardt, Mirjam, Engel, Matthias, Cabot, Peter J., Wood, John N., Vlachova, Viktorie, Reeh, Peter W., Lewis, Richard J. and Zimmermann, Katharina (2012). Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO Journal, 31 (19), 3795-3808. doi: 10.1038/emboj.2012.207

omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels

Tranberg, Charlotte Elisabet, Yang, Aijun, Vetter, Irina, McArthur, Jeffrey R., Baell, Jonathan B., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2012). omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels. Marine Drugs, 10 (10), 2349-2368. doi: 10.3390/md10102349

Towards an integrated venomics approach for accelerated conopeptide discovery

Jutty Rajan, Prashanth, Lewis, Richard J. and Dutertre, Sebastien (2012). Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon, 60 (4), 470-477. doi: 10.1016/j.toxicon.2012.04.340

Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors

Marcon, Francesca, Leblanc, Mathieu, Vetter, Irina, Lewis, Richard J., Escoubas, Pierre and Nicholson, Graham M. (2012). Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors. Biochemical Pharmacology, 84 (6), 851-863. doi: 10.1016/j.bcp.2012.06.024

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

Vetter, Irina, Dekan, Zoltan, Knapp, Oliver, Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2012). Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology, 84 (4), 540-548. doi: 10.1016/j.bcp.2012.05.008

Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB

Knapp, O., Nevin, S. T., Yasuda, T., Lawrence, N., Lewis, R. J. and Adams, D. J. (2012). Biophysical properties of Naᵥ 1.8/Naᵥ 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology, 166 (7), 2148-2160. doi: 10.1111/j.1476-5381.2012.01955.x

Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea

Muttenthaler, Markus, Dutertre, Sebastien, Wingerd, Joshua S., Aini, John W., Walton, Hugh, Alewood, Paul F. and Lewis, Richard J. (2012). Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea. Nautilus, 126 (2), 47-56.

Therapeutic potential of cone snail venom peptides (conopeptides)

Vetter, Irina and Lewis, Richard J. (2012). Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry, 12 (14), 1546-1552. doi: 10.2174/156802612802652457

Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells

Vetter, Irina, Mozar, Christine A., Durek, Thomas, Wingerd, Joshua S., Alewood, Paul F., Christie, Macdonald J. and Lewis, Richard J. (2012). Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83 (11), 1562-1571. doi: 10.1016/j.bcp.2012.02.022

Conus venom peptide pharmacology

Lewis, Richard J., Dutertre, Sebastien, Vetter, Irina and Christie, MacDonald J. (2012). Conus venom peptide pharmacology. Pharmacological Reviews, 64 (2), 259-298. doi: 10.1124/pr.111.005322

Discovery and development of the chi-conopeptide class of analgesic peptides

Lewis, Richard J. (2012). Discovery and development of the chi-conopeptide class of analgesic peptides. Toxicon, 59 (4), 524-528. doi: 10.1016/j.toxicon.2011.07.012

Conotoxin engineering: Dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability

Dekan, Zoltan, Wang, Ching-I Anderson, Andrews, Robert K., Lewis, Richard J. and Alewood, Paul F. (2012). Conotoxin engineering: Dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic and Biomolecular Chemistry, 10 (30), 5791-5794. doi: 10.1039/c2ob25133g

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

Schroeder, Christina I., Nielsen, Katherine J., Adams, Denise A., Loughnan, Marion L., Thomas, Linda, Alewood, Paul F., Lewis, Richard J. and Craik, David J. (2012). Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers, 98 (4), 345-356. doi: 10.1002/bip.22031

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

Schroeder, Christina I., Adams, Denise, Thomas, Linda, Alewood, Paul F. and Lewis, Richard J. (2012). N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers, 98 (2), 161-165. doi: 10.1002/bip.22032

Ciguatera fish poisoning in the Pacific Islands (1998 - 2008)

Skinner, Mark P., Brewer, Tom D., Johnstone, Ron, Fleming, Lora E. and Lewis, Richard J. (2011). Ciguatera fish poisoning in the Pacific Islands (1998 - 2008). PLoS Neglected Tropical Diseases, 5 (12) e1416, e1416.1-e1416.7. doi: 10.1371/journal.pntd.0001416

Venom peptide modulators of the immune system

Inserra, Marco C. and Lewis, Richard J. (2011). Venom peptide modulators of the immune system. Inflammation and Allergy - Drug Targets, 10 (5), 399-410. doi: 10.2174/187152811797200687

α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure

Dekan, Zoltan, Vetter, Irina, Daly, Norelle L., Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2011). α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society, 133 (40), 15866-15869. doi: 10.1021/ja206408q

Venomics: A new paradigm for natural products-based drug discovery

Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4

Modulating oxytocin activity and plasma stability by disulfide bond engineering

Muttenthaler, Markus, Andersson, Asa, Dantas de Araujo, Aline, Dekan, Zoltan, Lewis, Richard J. and Alewood, Paul F. (2010). Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry, 53 (24), 8585-8596. doi: 10.1021/jm100989w

Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction

Mattei, Cesar, Marquais, Michel, Schlumberger, Sebastien, Molgo, Jordi, Vernoux, Jean-Paul, Lewis, Richard J. and Benoit, Evelyne (2010). Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction. Toxicon, 56 (5), 759-767. doi: 10.1016/j.toxicon.2009.07.026

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal

Nguyen-Huu, Truong D., Mattei, César, Wen, Peter J., Bourdelais, Andrea J., Lewis, Richard J., Benoit, Evelyne, Baden, Daniel G., Molgó, Jordi and Meunier, Frédéric A. (2010). Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal. Toxicon, 56 (5), 792-796. doi: 10.1016/j.toxicon.2009.08.002

Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning

Stewart, I., Lewis, Richard J., Eaglesham, G. K., Graham, G. C., Poole, S. and Craig, S. B. (2010). Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning. Annals of Tropical Medicine & Parasitology, 104 (7), 557-571. doi: 10.1179/136485910X12851868779902

Human fatality associated with Pacific ciguatoxin contaminated fish

Hamilton, Brett, Whittle, Nigel, Shaw, Glen, Eaglesham, Geoff, Moore, Michael R. and Lewis, Richard J. (2010). Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon, 56 (5), 668-673. doi: 10.1016/j.toxicon.2009.06.007

Chemical synthesis and structure of the prokineticin Bv8

Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330

Toxins in Seafood

Lewis, Richard J. and Poli, Mark (2010). Toxins in Seafood. Toxicon, 56 (2), 107-107. doi: 10.1016/j.toxicon.2010.05.002

α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors

Grishin, Anton, Wang, Ching-I. A., Muttenthaler, Markus, Alewood, Paul F., Lewis, Richard J. and Adams, David J. (2010). α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 285 (29), 22254-22263. doi: 10.1074/jbc.M110.111880

Use of venom peptides to probe ion channel structure and function

Dutertre, Sébastien and Lewis, Richard J. (2010). Use of venom peptides to probe ion channel structure and function. Journal of Biological Chemistry, 285 (18), 13315-13320. doi: 10.1074/jbc.R109.076596

Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha 3 beta 2 nicotinic receptor

Luo, Sulan, Akondi, Kalyana Bharati, Zhangsun, Dongting, Wu, Yong, Zhu, Xiaopeng, Hu, Yuanyan, Christensen, Sean, Dowell, Cheryl, Daly, Norelle L., Craik, David J., Wang, Ching-I. Anderson, Lewis, Richard J., Alewood, Paul F. and McIntosh, J. Michael (2010). Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha 3 beta 2 nicotinic receptor. Journal of Biological Chemistry, 285 (16), 12355-12366. doi: 10.1074/jbc.M109.079012

Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity

Wang, Ching-I Anderson and Lewis, Richard J. (2010). Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity. Biochemical Pharmacology, 79 (8), 1083-1091. doi: 10.1016/j.bcp.2009.11.019

Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists

Muttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010). Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 (10), 3514-3522. doi: 10.1021/ja910602h

Characterization of endogenous calcium responses in neuronal cell lines

Vetter, Irina and Lewis, Richard J. (2010). Characterization of endogenous calcium responses in neuronal cell lines. Biochemical Pharmacology, 79 (6), 908-920. doi: 10.1016/j.bcp.2009.10.020

Analgesic omega-conotoxins CVIE and CVIF selectively and voltage dependently block recombinant and native N-type calcium channels

Berecki, G., Motin, L., Haythornthwaite, A., Vink, S., Bansal, P., Drinkwater, R., Wang, C. I., Moretta, M., Lewis, R. J., Alewood, P. F., Christie, M. J. and Adams, D. J. (2009). Analgesic omega-conotoxins CVIE and CVIF selectively and voltage dependently block recombinant and native N-type calcium channels. Molecular Pharmacology, 77 (2), 139-148. doi: 10.1124/mol.109.058834

Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh (vol 54, pg 62, 2009)

Lewis, Richard J., Yang, Aijun and Jones, Alun (2009). Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh (vol 54, pg 62, 2009). Toxicon, 54 (6), 897-897. doi: 10.1016/j.toxicon.2009.06.025

Rapid access to omega conotoxin chimeras using native chemical ligation

Hopping , Gene, Lewis, Richard J. and Alewood, Paul F. (2009). Rapid access to omega conotoxin chimeras using native chemical ligation. Austalian Journal of Chemistry, 62 (10), 1333-1338. doi: 10.1071/CH09216

X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

Brust, Andreas, Palant, Elka, Croker, Daniel E., Colless, Barbara, Drinkwater, Roger, Patterson, Brad, Schroeder, Christina I., Wilson, David, Nielsen, Carsten K., Smith, Maree T., Alewood, Danne, Alewood, Paul F and Lewis, Richard J. (2009). X-conopeptide pharmacophore development: Toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry, 52 (22), 6991-7002. doi: 10.1021/jm9003413

Omega-Conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine

Andersson, Asa, Baell, Jonathan B., Duggan, Peter J., Graham, Janease E., Lewis, Richard J., Lumsden, Natalie G., Tranberg, C. Elisabet, Tuck, Kellie L. and Yang, Aijun (2009). Omega-Conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine. Bioorganic and Medicinal Chemistry, 17 (18), 6659-6670. doi: 10.1016/j.bmc.2009.07.063

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

Fry, Bryan G., Roelants, Kim, Champagne, Donald E., Scheib, Holger, Tyndall, Joel D. A., King, Glenn F., Nevalainen, Timo J., Norman, Janette A., Lewis, Richard J., Norton, Raymond S., Renjifo, Camila and Rodriguez de la Vega, Ricardo C. (2009). The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms. Annual Review of Genomics and Human Genetics, 10, 483-511. doi: 10.1146/annurev.genom.9.081307.164356

Isolation and characterization of peptides from momordica cochinchinensis seeds

Chan, L. Y., Wang, C. K., Major, J. M., Greenwood, K. P., Lewis, R. J., Craik, D. J. and Daly, N. L. (2009). Isolation and characterization of peptides from momordica cochinchinensis seeds. JOURNAL OF NATURAL PRODUCTS, 72 (8), 1453-1458. doi: 10.1021/np900174n

Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS

Davis, J, Jones, Al and Lewis, R. J. (2009). Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides, 30 (7), 1222-1227. doi: 10.1016/j.peptides.2009.03.019

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

Loughnan, Marion L., Nicke, Annette, Lawrence, Nicole and Lewis, Richard J. (2009). Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry, 48 (17), 3717-3729. doi: 10.1021/bi9000326

Low molecular weight non-peptide mimics of omega-conotoxin GVIA

Duggan, P. J., Lewis, R. J., Lok, Y. P., Lumsden, N. G., Tuck, K. L. and Yang, A. J. (2009). Low molecular weight non-peptide mimics of omega-conotoxin GVIA. Bioorganic and Medicinal Chemistry Letters, 19 (10), 2763-2765. doi: 10.1016/j.bmcl.2009.03.130

Conotoxins: molecular and therapeutic targets

Lewis, Richard J (2009). Conotoxins: molecular and therapeutic targets. Progress in molecular and subcellular biology, 46, 45-65. doi: 10.1007/978-3-540-87895-7_2

Role of voltage-gated calcium channels in ascending pain pathways

Zamponi, G. W., Lewis, R. J., Todorovic, S. M., Arneric, S. P. and Snutch, T. P. (2009). Role of voltage-gated calcium channels in ascending pain pathways. Brain Research Revues, 60 (1), 84-89. doi: 10.1016/j.brainresrev.2008.12.021

Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins fish flesh

Lewis, Richard J., Yang, Aijun and Jones, Alun (2009). Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins fish flesh. Toxicon, 54 (1), 62-66. doi: 10.1016/j.toxicon.2009.03.013

Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues

Millard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009). Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 (8), 4944-4951. doi: 10.1074/jbc.M804950200

Conotoxin Venom Peptide Therapeutics

Lewis, RJ (2009). Conotoxin Venom Peptide Therapeutics. Advances in Experimental Medicine & Biology, 655 (x), 44-48. doi: 10.1007/978-1-4419-1132-2_5

Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells

Mattei, C, Wen, PJ, Nguyen-Huu, TD, Alvarez, M, Benoit, E, Bourdelais, AJ, Lewis, RJ, Baden, DG, Molgo, J and Meunier, FA (2008). Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells. PLoS One, 3 (10) e3448, 1-16. doi: 10.1371/journal.pone.0003448

Molecular engineering of conotoxins: The importance of loop size to alpha-conotoxin structure and function

Jin, Ai-Hua, Daly, N. L., Nevin, S. T., Wang, C. I. A., Dutertre, S., Lewis, R. J., Adams, D. J., Craik, D. J. and Alewood, P. F. (2008). Molecular engineering of conotoxins: The importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry, 51 (18), 5575-5584. doi: 10.1021/jm800278k

Phorbasins G-K: new cytotoic diterpenes from a southern Australian marine sponge, Phorbas sp

Zhang, Hua, Major, Jodie M., Lewis, Richard J. and Capon, Robert J. (2008). Phorbasins G-K: new cytotoic diterpenes from a southern Australian marine sponge, Phorbas sp. Organic and Biomolecular Chemistry, 6 (20), 3811-3815. doi: 10.1039/b808866g

Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure

Dumon, Claire, Varvak, Alexander, Wall, Mark A., Flint, James E., Lewis, Richard J., Lakey, Jeremy H., Morland, Carl, Luginbühl, Peter, Healey, Shaun, Todaro, Thomas, DeSantis, Grace, Sun, May, Parra-Gessert, Lilian, Tan, Xuqiu, Weiner, David P. and Gilbert, Harry J. (2008). Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. Journal of Biological Chemistry, 283 (33), 22557-22564. doi: 10.1074/jbc.M800936200

Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

Schroeder, C.I, Ekberg, J, Nielsen, K.J, Adams, D, Loughnan, M L, Thomas, L, Adams, D J, Alewood, P F and Lewis, R J (2008). Neuronally selective micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. Journal of Biological Chemistry, 283 (31), 21621-21628. doi: 10.1074/jbc.M802852200

Crystal Structure of a Cellulosomal Family 3 Carbohydrate Esterase from Clostridium thermocellum Provides Insights into the Mechanism of Substrate Recognition

Correia, Márcia A.S., Prates, José A.M., Brás, Joana, Fontes, Carlos M.G.A., Newman, Joseph A., Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008). Crystal Structure of a Cellulosomal Family 3 Carbohydrate Esterase from Clostridium thermocellum Provides Insights into the Mechanism of Substrate Recognition. Journal of Molecular Biology, 379 (1), 64-72. doi: 10.1016/j.jmb.2008.03.037

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide

Dutertre, Sébastien, Croker, Daniel, Daly, Norelle L., Andersson, Åsa, Muttenthaler, Markus, Lumsden, Natalie G., Craik, David J., Alewood, Paul F., Guillon, Gilles and Lewis, Richard J. (2008). Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptide. Journal of Biological Chemistry, 283 (11), 7100-7108. doi: 10.1074/jbc.M706477200

Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution

Quin, Maureen, Newman, Joseph, Firbank, Susan, Lewis, Richard J. and Marles-Wright, Jon (2008). Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64 (3), 196-199. doi: 10.1107/S1744309108003849

Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic GH11 Xylanases

Vardakou, Maria, Dumon, Claire, Murray, James W., Christakopoulos, Paul, Weiner, David P., Juge, Nathalie, Lewis, Richard J., Gilbert, Harry J. and Flint, James E. (2008). Understanding the Structural Basis for Substrate and Inhibitor Recognition in Eukaryotic GH11 Xylanases. Journal of Molecular Biology, 375 (5), 1293-1305. doi: 10.1016/j.jmb.2007.11.007

Synthesis and Ca(v)2.2 binding data for non-peptide mimetics of omega-conotoxin GVIA based on a 5-amino-anthranilamide core

Duggan, PJ, Faber, JM, Graham, JE, Lewis, RJ, Lumsden, NG and Tuck, KL (2008). Synthesis and Ca(v)2.2 binding data for non-peptide mimetics of omega-conotoxin GVIA based on a 5-amino-anthranilamide core. Australian Journal of Chemistry: an international journal for chemical science, 61 (1), 11-15. doi: 10.1071/CH07327

Stress responses of bacteria

Marles-Wright, Jon and Lewis, Richard J (2007). Stress responses of bacteria. Current Opinion in Structural Biology, 17 (6), 755-760. doi: 10.1016/j.sbi.2007.08.004

Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue

Blanchfield, J., Gallagher, O., Cros, C., Lewis, R., Alewood, P. and Toth, I. (2007). Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communication, 361 (1), 97-102. doi: 10.1016/j.bbrc.2007.06.138

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain

Drew, Liam J., Rugiero, Francois, Cesare, Paolo, Gale, Jonathan E., Abrahamsen, Bjarke, Bowden, Sarah, Heinzmann, Sebestian, Robinson, Michelle, Brust, Andreas, Colless, Barbara, Lewis, Richard J. and Wood, John N. (2007). High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One, 2 (6) e515, 1-11. doi: 10.1371/journal.pone.0000515

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

Lewis, Richard J., Schroeder, Christina I., Ekberg, Jenny, Nielsen, Katherine J., Loughnan, Marion, Thomas, Linda, Adams, Denise A., Drinkwater, Roger, Adams, David J. and Alewood, Paul F. (2007). Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology, 71 (3), 676-685. doi: 10.1124/mol.106.028225

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Dutertre, S., Ulens, C, Buttner, R, Fish, A, van Elk, R, Kendel, Y, Hopping, G., Alewood, P. F., Schroeder, C., Nicke, A, Smit, AB, Sixma, TK and Lewis, R. J. (2007). AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. Embo Journal, 26 (16), 3858-3867. doi: 10.1038/sj.emboj.7601785

Synthesis and In vitro biological activity of cyclic lipophilic χ-conotoxin MrIA analogues

Dekan, Z., Paczkowski, F. A., Lewis, R. J and Alewood, P. F. (2007). Synthesis and In vitro biological activity of cyclic lipophilic χ-conotoxin MrIA analogues. International Journal of Peptide Research And Therapeutics, 13 (1-2), 307-312. doi: 10.1007/s10989-007-9083-2

chi-conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model

Paczkowski, Filip A., Sharpe, Iain A., Dutertre, Sébastien and Lewis, Richard J. (2007). chi-conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. Journal of Biological Chemistry, 282 (24), 17837-17844. doi: 10.1074/jbc.M610813200

omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels

Motin, Leonid, Yasuda, Takahiro, Schroeder, Christina I., Lewis, Richard J. and Adams, David J. (2007). omega-Conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. European Journal of Neuroscience, 25 (2), 435-444. doi: 10.1111/j.1460-9568.2006.05299.x

Cloning and characterization of natriuretic peptides from the venom glands of Australian elapids

St Pierre, Liam, Flight, Simone M., Masci, Paul P., Hanchard, Kim J., Lewis, Richard J., Alewood, Paul F., De Jersey, John and Lavin, Martin F. (2006). Cloning and characterization of natriuretic peptides from the venom glands of Australian elapids. Biochimie, 88 (12), 1923-1931. doi: 10.1016/j.biochi.2006.06.014

mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

Ekberg, J., Jayamanne, A., Vaughan, C. W., Aslan, S., Thomas, L., Mould, J., Drinkwater, R., Baker, M. D., Abrahamsen, B., Wood, J. N., Adams, D. J., Christie, M. J. and Lewis, R. J. (2006). mu O-conotoxin MrVIB selectively blocks Na(v)1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of The National Academy of Sciences of The United States of America, 103 (45), 17030-17035. doi: 10.1073/pnas.0601819103

N-type calcium channel blockers: Novel therapeutics for the treatment of pain

Schroeder, I. C., Doering, J., Zamponi, W. and Lewis, R. J. (2006). N-type calcium channel blockers: Novel therapeutics for the treatment of pain. Medicinal Chemistry, 2 (5), 535-543. doi: 10.2174/157340606778250216

Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum

Loughnan, Marion, Nicke, Annette, Jones, Alun, Schroeder, Christina I., Nevin, Simon T., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2006). Identification of a novel class of nicotinic receptor antagonists - Dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. Journal of Biological Chemistry, 281 (34), 24745-24755. doi: 10.1074/jbc.M603703200

Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA

Baell, Jonathan B., Duggan, Peter J., Forsyth, Stewart A., Lewis, Richard J., Lok, Y. Phei, Schroeder, Christina I. and Shepherd, Nicholas E. (2006). Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of omega-conotoxin GVIA. Tetrahedron, 62 (31), 7284-7292. doi: 10.1016/j.tet.2006.05.041

Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential

Schroeder, C. I. and Lewis, R. J. (2006). Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. Marine Drugs, 4 (3), 193-214. doi: 10.3390/md403193

Ciguatera: Australian perspectives on a global problem

Lewis, R. J. (2006). Ciguatera: Australian perspectives on a global problem. Toxicon, 48 (7), 799-809. doi: 10.1016/j.toxicon.2006.07.019

Ciguatoxins: Cyclic polyether modulators of voltage-gated Iion channel function

Nicholson, Graham M. and Lewis, Richard J. (2006). Ciguatoxins: Cyclic polyether modulators of voltage-gated Iion channel function. Marine Drugs, 4 (3), 82-118. doi: 10.3390/md403082

Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail

Dutertre, S., Lumsden, N. G., Alewood, P. F. and Lewis, R. J. (2006). Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. Febs Letters, 580 (16), 3860-3866. doi: 10.1016/j.febslet.2006.06.011

Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins

Sauviat, Martin-Pierre, Boydron-Le Garrec, Raphaële, Masson, Jean-Baptiste, Lewis, Richard L., Vernoux, Jean-Paul, Molgo, Jordi, Laurent, Dominique and Benoit, Evelyne (2006). Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins. Blood Cells Molecules And Diseases, 36 (1), 1-9. doi: 10.1016/j.bcmd.2005.10.007

NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G

Ragnarsson, L., Yasuda, T., Lewis, R. J., Dodd, P. R. and Adams, D. J. (2006). NMDA receptor subunit-dependent modulation by conantokin-G and Ala(7)-conantokin-G. Journal of Neurochemistry, 96 (1), 283-291. doi: 10.1111/j.1471-4159.2005.03574.x

Toxin insights into nicotinic acetylcholine receptors

Dutertre, S. and Lewis, R. J. (2006). Toxin insights into nicotinic acetylcholine receptors. Biochemical Pharmacology, 75 (6), 661-670. doi: 10.1016/j.bcp.2006.03.027

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, Carsten K., Lewis, Richard J., Alewood, Dianne, Drinkwater, Roger, Palant, Elka, Patterson, Margaret, Yaksh, Tony L, McCumber, Damon and Smith, Maree T. (2005). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain, 118 (1-2), 112-124. doi: 10.1016/j.pain.2005.08.002

Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers

Birinyi-Strachan, Liesl C., Davies, Michael J., Lewis, Richard J. and Nicholson, Graham M. (2005). Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers. Neuropharmacology, 49 (5), 669-686. doi: 10.1016/j.neuropharm.2005.04.024

Differential antagonism by conotoxin p-TIA of contractions mediated by distinct alpha(1)-adrenoceptor subtypes in rat vas deferens, spleen and aorta

Lima, Vanessa, Mueller, André, Kamikihara, Susana Y., Raymundi, Vanessa, Alewood, Dianne, Lewis, Richard J., Chen, Zhongjian, Minneman, Kenneth P. and Pupo, André S. (2005). Differential antagonism by conotoxin p-TIA of contractions mediated by distinct alpha(1)-adrenoceptor subtypes in rat vas deferens, spleen and aorta. European Journal of Pharmacology, 508 (1-3), 183-192. doi: 10.1016/j.ejphar.2004.12.011

Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators

Garrec, R. B. L., Benoit, E., Sauviat, M. P., Lewis, R. J., Molgo, J. and Laurent, D (2005). Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators. Toxicon, 46 (6), 625-634. doi: 10.1016/j.toxicon.2005.07.002

Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons

Birinyi-Strachan, L. C., Gunning, S. J., Lewis, R. J. and Nicholson, G. M. (2005). Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons. Toxicology And Applied Pharmacology, 204 (2), 175-186. doi: 10.1016/j.taap.2004.08.020

Solution structure of χ-conopeptide MrIA, a modulator of the human norepinephrine transporter

Nilsson, K. P. R., Lovelace, E. S., Caesar, C. E., Tynngard, N., Alewood, P. F., Johansson, H. M., Sharpe, I. A., Lewis, R. J., Daly, N. L. and Craik, D. J. (2005). Solution structure of χ-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers, 80 (6), 815-823. doi: 10.1002/bip.20302

The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor

Tsai, V. W. W., Dodd, P. R. and Lewis, R. J. (2005). The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. Neuroscience, 130 (2), 457-464. doi: 10.1016/j.neuroscience.2004.09.039

beta 2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor

Dutertre, S., Nicke, A. and Lewis, R. J. (2005). beta 2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. Journal of Biological Chemistry, 280 (34), 30460-30468. doi: 10.1074/jbc.M504229200

Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C

Delumeau, Olivier, Dutta, Sujit, Brigulla, Matthias, Kuhnke, Grit, Hardwick, Steven W., Völker, Uwe, Yudkin, Michael D. and Lewis, Richard J. (2004). Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C. Journal of Biological Chemistry, 279 (39), 40927-40937. doi: 10.1074/jbc.M405464200

The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer’s disease

Tsai, Vicky W. -W., Scott, Heather L., Lewis, Richard J. and Dodd, Peter R. (2004). The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in alzheimer’s disease. Neurotoxicity Research, 7 (1-2), 125-141. doi: 10.1007/BF03033782

Subtype-selective noncompetitive or competitive inhibition of human alpha(1)-adrenergic receptors by rho-TIA

Chen, Zhongjian, Rogge, George, Hague, Chris, Alewood, Dianne, Colless, Barbara, Lewis, Richard J. and Minneman, Kenneth P. (2004). Subtype-selective noncompetitive or competitive inhibition of human alpha(1)-adrenergic receptors by rho-TIA. Journal of Biological Chemistry, 279 (34), 35326-35333. doi: 10.1074/jbc.M403703200

The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels

Mould, J., Yasuda, T., Schroeder, C. I., Beedle, A. M., Doering, C. J., Zamponi, G. W., Adams, D. J. and Lewis, R. J. (2004). The alpha(2)delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Ca(v)2.2) calcium channels. Journal of Biological Chemistry, 279 (33), 34705-34714. doi: 10.1074/jbc.M310848200

Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells

Yasuda, T., Chen, L., Barr, W., McRory, J. E., Lewis, R. J., Adams, D. J. and Zamponi, G. W. (2004). Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. European Journal of Neuroscience, 20 (1), 1-13. doi: 10.1111/j.1460-9568.2004.03434.x

Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors

Kloda, A., Clements, J. D., Lewis, R. J. and Adams, D. J. (2004). Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology, 65 (6), 1386-1396. doi: 10.1124/mol.65.6.1386

Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors

Dutertre, Sébastien and Lewis, Richard J. (2004). Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors. European Journal of Biochemistry, 271 (12), 2327-2334. doi: 10.1111/j.1432-1033.2004.04147.x

The role of metabotropic glutamate receptors in glutamate-induced neuronal excitotoxicity in Alzheimers disease

Dodd, P., Tsai, V. and Lewis, R. (2004). The role of metabotropic glutamate receptors in glutamate-induced neuronal excitotoxicity in Alzheimers disease. Journal of Neurochemistry, 88 (Supplement 1)

Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone

Loughnan, M. L., Nicke, A., Jones, A., Adams, D. J., Alewood, P. F. and Lewis, R. J. (2004). Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry, 47 (5), 1234-1241. doi: 10.1021/jm031010o

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters

Lewis, R. J. (2004). Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters. Iubmb Life, 56 (2), 89-93. doi: 10.1080/15216540410001668055

Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors

Dutertre, Sébastien, Nicke, Annette, Tyndall, Joel D. A. and Lewis, Richard J. (2004). Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition, 17 (4), 339-347. doi: 10.1002/jmr.683

Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel

Schroeder, I.C., Smythe, M. L. and Lewis, R. J. (2004). Development of small molecules that mimic the binding of w-conotoxins at the N-type voltage-gated calcium channel. Molecular Diversity, 8 (2), 127-134. doi: 10.1023/B:MODI.0000025656.79632.86

Differential expression of calcium channels in sympathetic and parasympathetic preganglionic inputs to neurons in paracervical ganglia of guinea-pigs

Jobling, P., Gibbins, I. L., Lewis, R. J. and Morris, J. L. (2004). Differential expression of calcium channels in sympathetic and parasympathetic preganglionic inputs to neurons in paracervical ganglia of guinea-pigs. Neuroscience, 127 (2), 455-466. doi: 10.1016/j.neuroscience.2004.05.005

Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons

Morris, Judy L., Ozols, Daina I., Lewis, Richard J., Gibbins, Ian L. and Jobling, Phillip (2004). Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons. British Journal of Pharmacology, 141 (6), 961-970. doi: 10.1038/sj.bjp.0705712

Overexpressed Ca-v beta 3 inhibits N-type (Ca(v)2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow" and "closed-state" inactivation

Yasuda, T., Lewis, R. J. and Adams, D. J. (2004). Overexpressed Ca-v beta 3 inhibits N-type (Ca(v)2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow" and "closed-state" inactivation. Journal of General Physiology, 123 (4), 401-416. doi: 10.1085/jgp.200308967

Structures of mu O-conotoxins from Conus marmoreus - Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons

Daly, N. L., Ekberg, J. A., Thomas, L., Adams, D. J., Lewis, R. J. and Craik, D. J. (2004). Structures of mu O-conotoxins from Conus marmoreus - Inhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. Journal of Biological Chemistry, 279 (24), 25774-25782. doi: 10.1074/jbc.M313002200

Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA

Baell, J. B., Duggan, P. J., Forsyth, S. A., Lewis, R. J., Lok, Y. P. and Schroeder, C. I. (2004). Synthesis and biological evaluation of nonpeptide mimetics of co-conotoxin GVIA. Bioorganic & Medicinal Chemistry, 12 (15), 4025-4037. doi: 10.1016/j.bmc.2004.05.040

Twenty questions: Highlighting the pitfalls and possibilities of drug research

Ashcroft, F., Benos, D., Bezanilla, F., Chien, K., Choe, S., Clapham, D., Dougherty, D., Lazdunski, M., Levitan, I., Lewis, R. J., Liss, B., Lummis, S., Miller, C. W., North, A., Peters, J., Sanguinetti, M., Smart, T., Stuhmer, W., Vandenberg, J. I. and Verkman, A. (2004). Twenty questions: Highlighting the pitfalls and possibilities of drug research. Nature Review Drug Discovery Research, 3 (3), 238.

alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors (vol 554, pg 219, 2003)

Nicke, A, Samochocki, M, Loughnan, ML, Bansal, PS, Maelicke, A and Lewis, RJ (2004). alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors (vol 554, pg 219, 2003). Febs Letters, 557 (1-3), 294-294. doi: 10.1016/S0014-5793(03)01497-2

alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes

Nicke, Annette C., Wonnacott, Susan and Lewis, Richard J. (2004). alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes. European journal of biochemistry, 271 (12), 2305-2319. doi: 10.1111/j.1432-1033.2004.04145.x

alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors

Nicke, Annette, Samochocki, Marek, Loughnan, Marion L., Bansal, Paramjit S., Maelicke, Alfred and Lewis, Richard J. (2003). alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. Febs Letters, 554 (1-2), 219-223. doi: 10.1016/S0014-5793(03)01161-X

Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding

Pottier, I., Hamilton, B., Jones, A., Lewis, R. J. and Vernoux, J. P. (2003). Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding. Toxicon, 42 (6), 663-672. doi: 10.1016/j.toxicon.2003.09.004

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2003). Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship. Journal of Biological Chemistry, 278 (41), 40317-40323. doi: 10.1074/jbc.M213030200

χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter

Bryan-Lluka, Lesley J., Bonisch, Heinz and Lewis, Richard J. (2003). χ-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. Journal of Biological Chemistry, 278 (41), 40324-40329. doi: 10.1074/jbc.M213101200

Allosteric α1 adrenoceptor antagonism by the conopeptide ρ-TIA

Sharpe, I. A., Thomas, L., Loughnan, M., Motin, L., Palant, E., Croker, D. E., Alewood, D., Chen, S., Graham, R. M., Alewood, P. F., Adams, D. J. and Lewis, R. J. (2003). Allosteric α1 adrenoceptor antagonism by the conopeptide ρ-TIA. Journal of Biological Chemistry, 278 (36), 34451-34457. doi: 10.1074/jbc.M305410200

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII

Blanchfield, J. T., Dutton, J. T., Hogg, R. C., Gallagher, O. P., Craik, D. J., Jones, A., Adams, D. J., Lewis, R. J., Alewood, P. F. and Toth, I. (2003). Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of α-conotoxin MII. Journal of Medicinal Chemistry, 46 (7), 1266-1272. doi: 10.1021/jm020426j

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

Nicke, Annette, Loughnan, Marion L., Millard, Emma L., Alewood, Paul F., Adams, David J., Daly, Norelle L., Craik, David J. and Lewis, Richard J. (2003). Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. Journal of Biological Chemistry, 278 (5), 3137-3144. doi: 10.1074/jbc.M210280200

Ichthyotoxicity of Chattonella marina (Raphidophyceae) to damselfish (Acanthochromis polycanthus): the synergistic role of reactive oxygen species and free fatty acids

Marshall, J. A., Nichols, P. D., Hamilton, B., Lewis, R. J. and Hallegraeff, G. M. (2003). Ichthyotoxicity of Chattonella marina (Raphidophyceae) to damselfish (Acanthochromis polycanthus): the synergistic role of reactive oxygen species and free fatty acids. Harmful Algae, 2 (4), 273-281. doi: 10.1016/S1568-9883(03)00046-5

Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily

Milne, T. J., Abbenante, G., Tyndall, J. D. A., Halliday, J. and Lewis, R. J. (2003). Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. Journal of Biological Chemistry, 278 (33), 31105-31110. doi: 10.1074/jbc.M304843200

Therapeutic potential of venom peptides

Lewis, R. J. and Garcia, M. L. (2003). Therapeutic potential of venom peptides. Nature Reviews Drug Discovery, 2 (10) 114207, 790-802. doi: 10.1038/nrd1197

ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals

Adams, David J., Smith, Amanda B, Schroeder, Christina. I., Yasuda, Takahir and Lewis, Richard J. (2003). ω-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. Journal of Biological Chemistry, 278 (6), 4057-4062. doi: 10.1074/jbc.M209969200

Solution Structure of µ-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels

Nielsen, K. J., Watson, M., Adams, D. J., Hammarström, A. K., Gage, P. W., Hill, J. M., Craik, D. J., Thomas, L., Adams, D., Alewood, P. F. and Lewis, R. J. (2002). Solution Structure of µ-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels. Journal of Biological Chemistry, 277 (30), 27247-27255. doi: 10.1074/jbc.M201611200

Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry

Pottier, Ivannah, Vernoux, Jean-Paul, Jones, Alun and Lewis, Richard J. (2002). Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry. Toxicon, 40 (7) 1715, 929-939. doi: 10.1016/S0041-0101(02)00088-0

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5

Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies

Pottier, I., Vernoux, J. P., Jones, A. and Lewis, R. J. (2002). Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Additives And Contaminants, 19 (11), 1034-1042. doi: 10.1080/02652030210155378

Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons

Hogg, R. C., Lewis, R. J. and Adams, D. J. (2002). Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. European Journal of Neuroscience, 16 (2), 242-248. doi: 10.1046/j.1460-9568.2002.02071.x

Isolation and characterisation of Indian Ocean ciguatoxin

Hamilton, B., Hurbungs, M., Vernoux, J. P., Jones, A. and Lewis, R. J. (2002). Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon, 40 (6), 685-693. doi: 10.1016/S0041-0101(01)00259-8

Multiple ciguatoxins present in Indian Ocean reef fish

Hamilton, B., Hurbungs, M., Jones, A. and Lewis, R. J. (2002). Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon, 40 (9), 1347-1353. doi: 10.1016/S0041-0101(02)00146-0

Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex

Ragnarsson, L., Mortensen, M., Dodd, P. R. and Lewis, R. J. (2002). Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex. Journal of Neurochemistry, 81 (4), 765-779. doi: 10.1046/j.1471-4159.2002.00872.x

The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII

Blanchfield, Joanne T., Dutton, Julie T., Hogg, R. C., Craik, D. J., Adams, D. J., Lewis, R. J., Alewood, P. and Toth, I. (2001). The synthesis and structure of an n-terminal dodecanoic acid conjugate of a-conotoxin MII. Letters in Peptide Science, 8 (3-5), 235-239. doi: 10.1023/A:1016577832311

Ciguatera fish poisoning in the Caribbean islands and western Atlantic

Pottier, I., Vernoux, J. P. and Lewis, R. J. (2001). Ciguatera fish poisoning in the Caribbean islands and western Atlantic. Reviews of Environmental Contamination And Toxicolgy, 168, 99-141. doi: 10.1007/978-1-4613-0143-1_3

The changing face of ciguatera

Lewis, R. J. (2001). The changing face of ciguatera. Toxicon, 39 (1), 97-106. doi: 10.1016/S0041-0101(00)00161-6

Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter

Sharpe, I. A., Gehrmann, J., Loughnan, M. L., Thomas, L., Adams, D. A., Atkins, A., Palant, E., Craik, D. J., Adams, D. J., Alewood, P. F. and Lewis, R. J. (2001). Two new classes of conopeptides inhibit the alpha 1-adrenoceptor and noradrenaline transporter. Nature Neuroscience, 4 (9), 902-907. doi: 10.1038/nn0901-902

Ciguatera:Recent advances but the risk remains

Lehane, L. and Lewis, R. J. (2000). Ciguatera:Recent advances but the risk remains. International Journal of Food Microbiology, 61 (2-3), 91-125. doi: 10.1016/S0168-1605(00)00382-2

Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa - 1. Isolation, characterization and chemical synthesis

Hill, J. M., Atkins, A. R., Loughnan, M. L., Jones, A., Adams, D. A., Martin, R. C., Lewis, R. J., Craik, D. J. and Alewood, P. F. (2000). Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa - 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry, 267 (15), 4642-4648. doi: 10.1046/j.1432-1327.2000.01508.x

Ion channel toxins and therapeutics: From cone snail venoms to ciguatera.

Lewis, R. J. (2000). Ion channel toxins and therapeutics: From cone snail venoms to ciguatera.. Therapeutic Drug Monitoring, 22 (1), 61-64. doi: 10.1097/00007691-200002000-00013

Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes

Lewis, Richard J., Nielsen, Katherine J., Craik, David J., Loughnan, Marion L., Adams, Denise A., Sharpe, Iain A., Luchian, Tudor, Adams, David J., Bond, Trudy, Thomas, Linda, Jones, Alun, Matheson, Jodi-Lea, Drinkwater, Roger, Andrews, Peter R. and Alewood, Paul F. (2000). Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. Journal of Biological Chemistry, 275 (45), 35335-35344. doi: 10.1074/jbc.M002252200

Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels

Nielsen, K. J., Schroeder, T. and Lewis, R. J. (2000). Structure-activity relationships of w-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition, 13 (2), 55-70. doi: 10.1002/(SICI)1099-1352(200003/04)13:2<55::AID-JMR488>3.0.CO;2-O

Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor

Hogg, Ron C., Miranda, Les P., Craik, David J., Lewis, Richard J., Alewood, Paul F. and Adams, David J. (1999). Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. Journal of Biological Chemistry, 274 (51), 36559-36564. doi: 10.1074/jbc.274.51.36559

Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus

Nielsen, Katherine J., Adams, Denise A., Alewood, Paul F., Lewis, Richard J., Thomas, Linda, Schroeder, Tina and Craik, David J. (1999). Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry, 38 (21), 6741-6751. doi: 10.1021/bi982980u

Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators

Nielsen, Katherine J., Skjaerbaek, Niels, Dooley, Michael, Adams, Denise A., Mortensen, Martin, Dodd, Peter R., Craik, David J., Alewood, Paul F. and Lewis, Richard J. (1999). Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators. Journal of Medicinal Chemistry, 42 (3), 415-426. doi: 10.1021/jm981052q

A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C

Eriksson, Ludvig, Guy, Sharon, Perlmutter, Patrick and Lewis, Richard (1999). A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C. Journal of Organic Chemistry, 64 (22), 8396-8398. doi: 10.1021/jo990389c

Conotoxins and their potential pharmaceutical applications

Adams, D. J., Alewood, P. F., Craik, D. J., Drinkwater, R. D. and Lewis, R. J. (1999). Conotoxins and their potential pharmaceutical applications. Drug Development Research, 46 (3-4 Special Issue: Biotechnology and Pharmacology in Australia), 219-234. doi: 10.1002/(SICI)1098-2299(199903/04)46:3/4<219::AID-DDR7>3.0.CO;2-S

Differential Actions of Pacific Ciguatoxin-1 on Sodium Channel Subtypes in Mammalian Sensory Neurons

Strachan, Liesl C., Lewis, Richard J. and Nicholson, Graham M. (1999). Differential Actions of Pacific Ciguatoxin-1 on Sodium Channel Subtypes in Mammalian Sensory Neurons. The Journal of Pharmacology and Experimental Therapeautics, 288 (1), 379-388.

HPLC/Tandem Electrospray Mass Spectrometry for the Determination of Sub-ppb Levels of Pacific and Caribbean Ciguatoxins in Crude Extracts of Fish

Lewis, R., Jones, A. and Vernoux, J. (1999). HPLC/Tandem Electrospray Mass Spectrometry for the Determination of Sub-ppb Levels of Pacific and Caribbean Ciguatoxins in Crude Extracts of Fish. Analytical Chemistry, 71 (1), 247-250. doi: 10.1021/ac980598h

Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels

Nielsen, Katherine J., Adams, Denise, Thomas, Linda, Bond, Trudy, Alewood, Paul F., Craik, David J. and Lewis, Richard J. (1999). Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology, 289 (5), 1405-1421. doi: 10.1006/jmbi.1999.2817

The 1.1 angstrom resolution crystal structure of [Tyr15]EpI, a novel α-conotoxin from Conus episcopatus, solved by direct methods

Hu, Shu-Hong, Loughnan, M., Miller, R., Weeks, C.M., Blessing, R.H., Alewood, P.F., Lewis, R.J. and Martin, J.L. (1998). The 1.1 angstrom resolution crystal structure of [Tyr15]EpI, a novel α-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry, 37 (33), 11425-11433. doi: 10.1021/bi9806549

Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones

Hogg, R. C., Lewis, R. J. and Adams, D. J. (1998). Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neuroscience Letters, 252 (2), 103-106. doi: 10.1016/S0304-3940(98)00575-8

alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors

Loughnan, Marion, Bond, Trudy, Atkins, Anne, Cuevas, Javier, Adams, David J., Broxton, Natalie M., Livett, Bruce G., Down, John G., Jones, Alun, Alewood, Paul F. and Lewis, Richard J. (1998). alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. Journal of Biological Chemistry, 273 (25), 15667-15674. doi: 10.1074/jbc.273.25.15667

Environmental poisoning: Presentation and management

Moore, MR, Ng, JC and Lewis, RJ (1998). Environmental poisoning: Presentation and management. Therapeutic Drug Monitoring, 20 (5), 502-509. doi: 10.1097/00007691-199810000-00010

Structure of Caribbean ciguatoxin isolated from Caranx latus

Lewis, RJ, Vernoux, JP and Brereton, IM (1998). Structure of Caribbean ciguatoxin isolated from Caranx latus. Journal of The American Chemical Society, 120 (24), 5914-5920. doi: 10.1021/ja980389e

Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus)

Vernoux, JP and Lewis, RJ (1997). Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus). Toxicon, 35 (6), 889-900. doi: 10.1016/S0041-0101(96)00191-2

A Queensland family with ciguatera after eating coral trout

Fenner, PJ, Lewis, RJ, Williamson, JA and Williams, ML (1997). A Queensland family with ciguatera after eating coral trout. Medical Journal of Australia, 166 (9), 473-475. doi: 10.5694/j.1326-5377.1997.tb123219.x

Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among US soldiers in Haiti

Poli, MA, Lewis, RJ, Dickey, RW, Musser, SM, Buckner, CA and Carpenter, LG (1997). Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among US soldiers in Haiti. Toxicon, 35 (5), 733-741. doi: 10.1016/S0041-0101(96)00166-3

Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography mass spectrometry

Lewis, RJ and Jones, A (1997). Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography mass spectrometry. Toxicon, 35 (2), 159-168. doi: 10.1016/S0041-0101(96)00132-8

Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy

Skjaerbaek, N, Nielsen, KJ, Lewis, RJ, Alewood, P and Craik, DJ (1997). Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. Journal of Biological Chemistry, 272 (4), 2291-2299. doi: 10.1074/jbc.272.4.2291

Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in East Arnhem Land, Australia

Lucas R.E., Lewis R.J. and Taylor J.M. (1997). Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in East Arnhem Land, Australia. Natural Toxins, 5 (4), 136-140. doi: 10.1002/19970504NT2

Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA

Scanlon, MJ, Naranjo, D, Thomas, L, Alewood, PF, Lewis, RJ and Craik, DJ (1997). Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure, 5 (12), 1585-1597. doi: 10.1016/S0969-2126(97)00307-9

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: Comparison of MVIIA, SVIB and SNX-202

Nielsen, KJ, Thomas, L, Lewis, RJ, Alewood, PF and Craik, DJ (1996). A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: Comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology, 263 (2), 297-310. doi: 10.1006/jmbi.1996.0576

Secrets of the cone shell

Lewis R., Alewood P., Dooley M., Martin J., Drinkwater R., Craik D. and Andrews P. (1996). Secrets of the cone shell. Today's Life Science, 8 (8), 16-18+20+22+24.

Electrical-Activity in Rat Tail Artery During Asynchronous Activation of Postganglionic Nerve-Terminals by Ciguatoxin-1

Brock, JA, McLachlan, EM, Jobling, P and Lewis, RJ (1995). Electrical-Activity in Rat Tail Artery During Asynchronous Activation of Postganglionic Nerve-Terminals by Ciguatoxin-1. British Journal of Pharmacology, 116 (4), 2213-2220. doi: 10.1111/j.1476-5381.1995.tb15056.x

Lophozozymus Pictor Toxin - a Fluorescent Structural Isomer of Palytoxin

Lau, CO, Tan, CH, Khoo, HE, Yuen, R, Lewis, RJ, Corpuz, GP and Bignami, GS (1995). Lophozozymus Pictor Toxin - a Fluorescent Structural Isomer of Palytoxin. Toxicon, 33 (10), 1373-1377. doi: 10.1016/0041-0101(95)00075-W

Sub Nanomolar Concentrations of Ciguatoxin-1 Excite Preganglionic Terminals in Guinea-Pig Sympathetic-Ganglia

Hamblin, PA, McLachlan, EM and Lewis, RJ (1995). Sub Nanomolar Concentrations of Ciguatoxin-1 Excite Preganglionic Terminals in Guinea-Pig Sympathetic-Ganglia. Naunyn-Schmiedebergs Archives of Pharmacology, 352 (2), 236-246. doi: 10.1007/BF00176780

Detection of Sodium-Channel Toxins - Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts

Manger, RL, Leja, LS, Lee, SY, Hungerford, JM, Hokama, Y, Dickey, RW, Granade, HR, Lewis, R, Yasumoto, T and Wekell, MM (1995). Detection of Sodium-Channel Toxins - Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts. Journal of Aoac International, 78 (2), 521-527.

Cooliatoxin, the first toxin from Coolia monotis (dinophyceae)

Holmes M.J., Lewis R.J., Jones A. and Hoy A.W.W. (1995). Cooliatoxin, the first toxin from Coolia monotis (dinophyceae). Natural Toxins, 3 (5), 355-362. doi: 10.1002/nt.2620030506

Ciguatera and herbivores: uptake and accumulation of ciguatoxins in Ctenochaetus striatus on the Great Barrier Reef

Lewis, R. J. (1994). Ciguatera and herbivores: uptake and accumulation of ciguatoxins in Ctenochaetus striatus on the Great Barrier Reef. Memoirs - Queensland Museum, 34 (3), 565-570.

Ciguatera: Risk perception and fish ingestion

Pearn, John H. and Lewis, R. (1994). Ciguatera: Risk perception and fish ingestion. Memoirs of the Queensland Museum, 34 (3), 605-6068.

Drugs from the peptide venoms of marine cone shells.

Lewis R.J., Bingham J.P., Jones A., Alewood P.F. and Andrews P.R. (1994). Drugs from the peptide venoms of marine cone shells.. Australasian biotechnology, 4 (5), 298-300.

Invertebrates implicated in the transfer of gambiertoxins to the benthic carnivore Pomadasys maculatus

Lewis, R. J., Holmes, M. J. and Sellin, M. (1994). Invertebrates implicated in the transfer of gambiertoxins to the benthic carnivore Pomadasys maculatus. Memoirs - Queensland Museum, 34 (3), 561-564.

Lonspray mass spectrometry of ciguatoxin‐1, maitotoxin‐2 and ‐3, and related marine polyether toxins

Lewis R.J., Holmes M.J., Alewood P.F. and Jones A. (1994). Lonspray mass spectrometry of ciguatoxin‐1, maitotoxin‐2 and ‐3, and related marine polyether toxins. Natural Toxins, 2 (2), 56-63. doi: 10.1002/nt.2620020203

Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus

Holmes, Michael J. and Lewis, Richard J. (1994). Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus. Natural Toxins, 2 (2), 64-72. doi: 10.1002/nt.2620020204

The origin of ciguatera in Platypus Bay, Australia

Holmes, M. J., Lewis, R. J., Sellin, M. and Street, R. (1994). The origin of ciguatera in Platypus Bay, Australia. Memoirs - Queensland Museum, 34 (3), 505-512.

Origin and Transfer of Toxins Involved in Ciguatera

Lewis, RJ and Holmes, MJ (1993). Origin and Transfer of Toxins Involved in Ciguatera. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 106 (3), 615-628. doi: 10.1016/0742-8413(93)90217-9

Recovery of Ciguatoxin From Fish Flesh

Lewis, RJ and Sellin, M (1993). Recovery of Ciguatoxin From Fish Flesh. Toxicon, 31 (10), 1333-1336. doi: 10.1016/0041-0101(93)90407-A

Ciguatera and Mannitol - In-Vivo and In-Vitro Assessment in Mice

Lewis, RJ, Hoy, Aww and Sellin, M (1993). Ciguatera and Mannitol - In-Vivo and In-Vitro Assessment in Mice. Toxicon, 31 (8), 1039-1050. doi: 10.1016/0041-0101(93)90262-H

Ciguatoxin-2 Is a Diastereomer of Ciguatoxin-3

Lewis, RJ, Norton, RS, Brereton, IM and Eccles, CD (1993). Ciguatoxin-2 Is a Diastereomer of Ciguatoxin-3. Toxicon, 31 (5), 637-643. doi: 10.1016/0041-0101(93)90118-3

Comparative Action of 3 Major Ciguatoxins On Guinea-Pig Atria and Ilea

Lewis, RJ and Hoy, Aww (1993). Comparative Action of 3 Major Ciguatoxins On Guinea-Pig Atria and Ilea. Toxicon, 31 (4), 437-446. doi: 10.1016/0041-0101(93)90179-M

CIGUATERA - ECOLOGICAL, CLINICAL, AND SOCIOECONOMIC PERSPECTIVES

LEWIS, RJ and RUFF, TA (1993). CIGUATERA - ECOLOGICAL, CLINICAL, AND SOCIOECONOMIC PERSPECTIVES. Critical Reviews in Environmental Science and Technology, 23 (2), 137-156. doi: 10.1080/10643389309388447

Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins

Dickey, R. W., Bencsath, F. A., Granade, H. R. and Lewis, R. J. (1992). Liquid chromatographic mass spectrometric methods for the determination of marine polyether toxins. Bulletin de la Societe de pathologie exotique (1990), 85 (5 Pt 2), 514-515.

Socioeconomic impacts and management ciguatera in the Pacific

Lewis, R. J. (1992). Socioeconomic impacts and management ciguatera in the Pacific. Bulletin de la Societe de pathologie exotique (1990), 85 (5 Pt 2), 427-434.

Action of Ciguatoxin On Human Atrial Trabeculae

Lewis, RJ, Hoy, Aww and McGiffin, DC (1992). Action of Ciguatoxin On Human Atrial Trabeculae. Toxicon, 30 (8), 907-914. doi: 10.1016/0041-0101(92)90389-M

Multiple Ciguatoxins in the Flesh of Fish

Lewis, RJ and Sellin, M (1992). Multiple Ciguatoxins in the Flesh of Fish. Toxicon, 30 (8), 915-919. doi: 10.1016/0041-0101(92)90390-Q

Ciguatoxins Are Potent Ichthyotoxins

Lewis, RJ (1992). Ciguatoxins Are Potent Ichthyotoxins. Toxicon, 30 (2), 207-211. doi: 10.1016/0041-0101(92)90474-J

Purification and Characterization of Ciguatoxins From Moray Eel (Lycodontis-Javanicus, Muraenidae)

Lewis, RJ, Sellin, M, Poli, MA, Norton, RS, Macleod, JK and Sheil, MM (1991). Purification and Characterization of Ciguatoxins From Moray Eel (Lycodontis-Javanicus, Muraenidae). Toxicon, 29 (9), 1115-1127. doi: 10.1016/0041-0101(91)90209-A

Strain Dependent Production of Ciguatoxin Precursors (Gambiertoxins) by Gambierdiscus-Toxicus (Dinophyceae) in Culture

Holmes, MJ, Lewis, RJ, Poli, MA and Gillespie, NC (1991). Strain Dependent Production of Ciguatoxin Precursors (Gambiertoxins) by Gambierdiscus-Toxicus (Dinophyceae) in Culture. Toxicon, 29 (6), 761-775. doi: 10.1016/0041-0101(91)90068-3

Toxicity of Australian and French-Polynesian Strains of Gambierdiscus-Toxicus (Dinophyceae) Grown in Culture - Characterization of a New Type of Maitotoxin

Holmes, MJ, Lewis, RJ and Gillespie, NC (1990). Toxicity of Australian and French-Polynesian Strains of Gambierdiscus-Toxicus (Dinophyceae) Grown in Culture - Characterization of a New Type of Maitotoxin. Toxicon, 28 (10), 1159-1172. doi: 10.1016/0041-0101(90)90116-O

Ciguatera and mannitol: experience with a new treatment regimen

Pearn, J.H., Lewis, R.J., Ruff, T., Tait, M., Quinn, J., Murtha, W., King, G., Mallett, A. and Gillespie, N.C. (1989). Ciguatera and mannitol: experience with a new treatment regimen. Medical Journal of Australia, 151 (2), 77-80.

Negative Inotropic and Arrhythmic Effects of High-Doses of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles

Lewis, RJ (1988). Negative Inotropic and Arrhythmic Effects of High-Doses of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles. Toxicon, 26 (7), 639-649. doi: 10.1016/0041-0101(88)90246-2

Ciguatera in Australia - occurrence, clinical-features, pathophysiology and management

Gillespie, N.C., Lewis, R.J., Pearn, J.H., Bourke, A.T.C., Holmes, M.J., Bourke, J.B. and Shields, W.J. (1986). Ciguatera in Australia - occurrence, clinical-features, pathophysiology and management. Medical Journal of Australia, 145 (11-12), 584-590.

Direct and Indirect Effects of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles

Lewis, RJ and Endean, R (1986). Direct and Indirect Effects of Ciguatoxin On Guinea-Pig Atria and Papillary-Muscles. Naunyn-Schmiedebergs Archives of Pharmacology, 334 (3), 313-322. doi: 10.1007/BF00508787

Ciguatoxin From the Flesh and Viscera of the Barracuda, Sphyraena-Jello

Lewis, RJ and Endean, R (1984). Ciguatoxin From the Flesh and Viscera of the Barracuda, Sphyraena-Jello. Toxicon, 22 (5), 805-810. doi: 10.1016/0041-0101(84)90163-6

Mode of Action of Ciguatoxin From the Spanish Mackerel, Scomberomorus-Commersoni, On the Guinea-Pig Ileum and Vasdeferens

Lewis, RJ and Endean, R (1984). Mode of Action of Ciguatoxin From the Spanish Mackerel, Scomberomorus-Commersoni, On the Guinea-Pig Ileum and Vasdeferens. Journal of Pharmacology and Experimental Therapeutics, 228 (3), 756-760.

Occurrence of a Ciguatoxin-Like Substance in the Spanish Mackerel (Scomberomorus-Commersoni)

Lewis, RJ and Endean, R (1983). Occurrence of a Ciguatoxin-Like Substance in the Spanish Mackerel (Scomberomorus-Commersoni). Toxicon, 21 (1), 19-24. doi: 10.1016/0041-0101(83)90045-4

Purification of ciguatoxin-like material from Scomberomorus commersoni and its effect on the rat phrenic nerve-diaphragm

Lewis R.J. and Endean R. (1983). Purification of ciguatoxin-like material from Scomberomorus commersoni and its effect on the rat phrenic nerve-diaphragm. Toxicon, 21 (SUPPL. 3), 249-252. doi: 10.1016/0041-0101(83)90201-5

The effects of two stonefish skin toxins on guinea-pig atria

Cameron A.M., Wong Hoy A.W. and Lewis R.J. (1983). The effects of two stonefish skin toxins on guinea-pig atria. Toxicon, 21 (SUPPL. 3), 53-56. doi: 10.1016/0041-0101(83)90153-8

Toxic material from the crab Atergatis floridus

Endean R., Lewis R., Gyr P. and Williamson J. (1983). Toxic material from the crab Atergatis floridus. Toxicon, 21 (SUPPL. 3), 111-113. doi: 10.1016/0041-0101(83)90167-8

Ciguatera and pregnancy

Pearn, J., Harvey, P., Deambrosis, W., Lewis, R. and McKay, R. (1982). Ciguatera and pregnancy. Medical Journal of Australia, 1 (2), 57-58.

The Antispasmogenic Action On Guinea-Pig Ileum of a Fraction Obtained From the Toxic Skin Secretion of the Stonefish, Synanceia-Trachynis

Cameron, AM and Lewis, RJ (1982). The Antispasmogenic Action On Guinea-Pig Ileum of a Fraction Obtained From the Toxic Skin Secretion of the Stonefish, Synanceia-Trachynis. Toxicon, 20 (6), 991-1000. doi: 10.1016/0041-0101(82)90101-5

A Crinotoxin From the Skin Tubercle Glands of a Stonefish (Synanceia-Trachynis)

Cameron, AM, Surridge, J, Stablum, W and Lewis, RJ (1981). A Crinotoxin From the Skin Tubercle Glands of a Stonefish (Synanceia-Trachynis). Toxicon, 19 (1), 159-170. doi: 10.1016/0041-0101(81)90128-8

Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7

Dongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Characterization and structure-function of a novel spider-venom toxin Phlo3a at hNav1.2, 1.3 and 1.7. Venom to Drugs, Daydream Island, QLD, Australia, 15-19 March 2021.

Structure-function of the spider peptide ProTx-III

Zhao, Tianjiao, Rosengren, Johan K., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Structure-function of the spider peptide ProTx-III. Venom to Drugs, Daydream Island, QLD Australia, 15-19 March 2021.

Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2

Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.

Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy

Dongol, Y., Choi, P., Wilson, D., Cardoso, F. C. and Lewis, R. J. (2020). Rationally Designed Analogues of the Novel Spider-venom Peptide Phlo3a Shifts the Potency and Subtype Selectivity at Therapeutic Nav Channel Targets for Pain and Epilepsy. SBMS Postgraduate Symposium in Biomedical Sciences, Brisbane, QLD Australia, 24 November 2020.

Re-evaluating the nirvana cabal deployed by piscivorous cone snails

Dutt, Mriga, Giacomotto, Jean, Ragnarsson, Lotten, Andersson, Asa, Brust, Andreas, Deakan, Zoltan, Alewood, Paul F. and Lewis, Richard J. (2020). Re-evaluating the nirvana cabal deployed by piscivorous cone snails. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.044

The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation

Fernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014

Characterization of δ-conotoxin Tx-VIA as selective T-type modulator

Wang, Dan, Himaya, S. W. A., Giacomotto, Jean, Hasan, Mahadhi, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Characterization of δ-conotoxin Tx-VIA as selective T-type modulator. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD, Australia, 29 November 2019.

Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory properties

Mawlawi, Saja E., Zhao, Thianjiao, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Cooperative interactions of loops 1, 4 and C-terminal of the ICK spider peptide Tap1a engender NaV inhibitory properties. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]

Zhao, Tianjiao, Rosengren, K. Johan, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain

Cardoso, Fernanda C., King, Glenn F. and Lewis, R. J. (2019). Discovery of novel cav and nav modulators in spider venoms and applications in the development of drugs to treat chronic pain. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017. Oxford, United Kingdom: Elsevier.

Molecular interactions between spider toxins and the sodium channel Nav1.1

Hu, Huyiu, Lewis, Richard J. and Cardoso, Fernanda C. (2019). Molecular interactions between spider toxins and the sodium channel Nav1.1. Pain Retreat 2019, Stradbroke Island, QLD Australia, 27-29 May 2019.

New insights in ω-conotoxin analgesic efficacy in postsurgical pain and oxaliplatin/cisplatin induced peripheral neuropathy

Hasan, Mahadhi, Mueller, Alexander, Starobova, Hana, Vetter, Irina, Cardoso, Fernanda C. and Lewis, Richard J. (2019). New insights in ω-conotoxin analgesic efficacy in postsurgical pain and oxaliplatin/cisplatin induced peripheral neuropathy. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.

Can Phlo3a – a newly discovered spider knottin – meets the challenges to strategically modulate noxious Nav-channels?

Dongol, Y., Cardoso, F. C. and Lewis, R. J. (2018). Can Phlo3a – a newly discovered spider knottin – meets the challenges to strategically modulate noxious Nav-channels?. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Comparative analysis of transfection methods to establish high-throughput automated electrophysiology assays for key ion channels involved in pain

Hasan, M.D., Cardoso, F.C. and Lewis, R.J. (2018). Comparative analysis of transfection methods to establish high-throughput automated electrophysiology assays for key ion channels involved in pain. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.

Cardoso, F. C., Herzig, V., King, G. F. and Lewis, R. J. (2018). Counter screen of spider venoms reveals novel sodium and calcium channel inhibitors of chronic pain targets.. Gordon Research Conference on Venom Evolution, Function and Biomedical Applications 2018, Mount Snow, VT, United States, 5-10 August 2018.

Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]

Zhao, T., Cardoso, F.C. and Lewis, R.J. (2018). Disclosing the bioactive surface of the potent NaV channel inhibitor ProTx-III [μ-TRTX-Tp1a]. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation

Ferraz, C. R., Cardos, F. C., Clissa, P. B., Vetter, I., Verri Jr, W. A. and Lewis, R. J. (2018). Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.

NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF ITCH DURING CIGUATERA FISH POISONING

L'Herondelle, Killian, Misery, Laurent, Le Gall-Ianotto, Christelle, Philippe, Reginald, Talagas, Matthieu, Mignen, Olivier, Lewis, Richard and Le Garrec, Raphaele (2017). NEW INSIGHTS INTO THE PATHOPHYSIOLOGY OF ITCH DURING CIGUATERA FISH POISONING. UPPSALA: ACTA DERMATO-VENEREOLOGICA.

Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding

Hassan, Mahadhi, Abraham, Nikita, Ragnarsson, Lotten K.N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). Defining ω-conotoxin binding site and delineating the role of the α2δ1 subunit in ω-conotoxin binding. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.

Cardoso, Fernanda C., King, Glenn F. and Lewis, Richard J. (2017). Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain.. 19th World Congress of the International Society on Toxinology, Haikou City, Hainan Province, China, 24-31 October 2017.

High-throughput cell-based assays for screening Cav3.2 modulators from venoms

Wang, D., Herzig, V., Dekan, Z., Ragnarsson, Lotten K. N., Cardoso, Fernanda C. and Lewis, Richard J. (2017). High-throughput cell-based assays for screening Cav3.2 modulators from venoms. Venom to Drugs Conference 2017, Noosa Heads, QLD, Australia, 9-14 October 2017.

Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders

Cardoso, Fernanda C., Bellingham, Mark C., King, Glenn F. and Lewis, Richard J. (2017). Nav modulators in spider venoms and applications in the development of novel therapies for neurological disorders. Venom to Drugs Conference 2017, Noosa Heads, QLD Australia, 9-14 October 2017.

Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease

Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.

Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes

L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2016). Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes. 22nd Meeting of the French-Society-of-Toxinology (SFET), Paris, France, 10-11 December 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.01.007

The inhibition of neuronal calcium channels with aminobenzothiazole derivatives

Sairaman, Anjali, Cardoso, Fernanda Caldas , Lewis, Richard J., Kaliappana, Krishna P., Tuck, Kellie L. and Duggan, Peter J. (2016). The inhibition of neuronal calcium channels with aminobenzothiazole derivatives. RACI Medicinal Chemistry and Chemical Biology Conference 2016, Coogee Beach, NSW, Australia, 7-9 November 2016.

Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays

Cardoso, Fernanda Caldas , Herzig, Volker , King, Glenn F. and Lewis, Richard J. (2015). Harnessing animal venoms in the discovery of potent Nav inhibitors through fluorescent and automated patch clamp assays. 18th World Congress of the International Society on Toxinology, Oxford UK, 25-30 September 2015.

Discovery of voltage-gated sodium channel inhibitors from tarantula venoms

Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

Effets de la ciguatoxine P-CTX-2 sur la liberation induite de neuropeptides dans un modele de co-culture keratinocytes-neurones sensoriels

L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2014). Effets de la ciguatoxine P-CTX-2 sur la liberation induite de neuropeptides dans un modele de co-culture keratinocytes-neurones sensoriels. 32e Congrès Annuel de Recherche Dermatologique (CARD), Océanopolis, Brest, France, 25-27 June, 2014. Issy les Moulineaux, France: Elsevier Masson. doi: 10.1016/j.annder.2014.04.154

Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.

Erickson, A., Cardoso, F. C., Lewis, R. J. and King, G. F. (2014). Optimizing the potency and selectivity of a spider-venom peptide that inhibitis the analgesic target Nav1.7.. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.

SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID

Brust, A., Gori, A., Wang, C-I A., Harvey, P. J., Rosengren, K. J., Gelmi, M. L., Longh, R., Lewis, R. J. and Alewood, P. F. (2014). SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID. 33rd European Peptide Symposium, Sofia, Bulgaria, 31 August – 5 September 2014. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2687

Unique evolution of D-conotoxins for defence

Prashanth, J. R., Dutertre, S., Jean, A., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2014). Unique evolution of D-conotoxins for defence. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 August 2014.

Ciguatoxin-Induced Release of Neuropeptides in a Sensory Neuron-Keratinocyte Coculture Model

Le Garrec, Raphaele, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2013). Ciguatoxin-Induced Release of Neuropeptides in a Sensory Neuron-Keratinocyte Coculture Model. World Congress on Itch (WCI), Boston, MA United States, 21–23 September 2013. UPPSALA: ACTA DERMATO-VENEREOLOGICA. doi: 10.2340/00015555-1701

Discovery of novel spider peptides blocking hNav1.7

Cardoso, F. C., Herzig, V., Hauke, T., Lewis, R. J. and King, G. F. (2013). Discovery of novel spider peptides blocking hNav1.7. 3rd Annual Conference of the Toxinological Society of India and 1st International Conference on “Biology of Natural Toxins”, Goa, India, 19-21 December, 2013.

Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain

Cardoso, F. C., Herzig, V., Hauke, T., King, G. F. and Lewis, R. J. (2013). Harnessing high-throughput screening strategies for identification of selective hNav1.7 blockers for the treatment of chronic pain. CASB Division Symposium 2013, Brisbane Australia, 7 November, 2013.

The injected venom of vermivorous cone snails

Prashanth, J. R., Dutertre, S., Lavergne, V., Hamilton, B., Cardoso, F. C., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2013). The injected venom of vermivorous cone snails. 10th Australian Peptides Conference, Penang, Malaysia, 8-13 September 2013.

Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels

Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.033

Discovery and development of chi-conopeptides for the treatment of pain

Lewis, Richard J. (2012). Discovery and development of chi-conopeptides for the treatment of pain. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.040

Novel sources for potent and selective GPCR modulators

Muttenthaler, M., Dawson, P. E., Gruber, C. W., Bergmayr, C., Freissmuth, M., Andersson, A., Vetter, I., Dutertre, S., Lewis, R. J. and Alewood, P. F. (2012). Novel sources for potent and selective GPCR modulators. unknown, unknown, unknown. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2447

The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor

Ragnarsson, Lotten, Wang, Ching-I. Anderson, Andersson, Åsa, Fajarningsih, Dewi, Monks, Thea, Brust, Andreas, Rosengren, K. Johan and Lewis, Richard J. (2012). The allosteric binding site for rho-TIA on the extracellular surface of the alpha 1B-Adrenoceptor. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.137

The venom of Conus geographus revisited

Dutertre, Sébastien, Jin, Ai-hua, Alewood, Paul F. and Lewis, Richard J. (2012). The venom of Conus geographus revisited. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.100

Transcriptomic and peptidomic characterisation of the Conus marmoreus venom: Insights on conopeptide diversity and venomic processing

Jin, Ai-hua, Dutertre, Sébastien, Kaas, Quentin, Lewis, Richard J. and Alewood, Paul F. (2012). Transcriptomic and peptidomic characterisation of the Conus marmoreus venom: Insights on conopeptide diversity and venomic processing. 17th World Congress of the International-Society-on-Toxinology (IST)/Venom Week/4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, United States, 8-13 July 2012. Kidlington, Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.099

Accelerated biodiscovery of ion channel modulators

Vetter, Irina and Lewis, Richard J. (2011). Accelerated biodiscovery of ion channel modulators. 84th Annual Meeting of the Japanese Pharmacological Society/11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Yokohama, Japan, 22-24 March 2011. Kyoto, Japan: Nihon Yakuri Gakkai Henshuubu.

Conotoxins - blueprints for GPCR drug discovery?

Muttenthaler, M., Gruber, C. W., Andersson, A., Vetter, I., Nevin, S. T., Grishin, A. A., Dutertre, S., Daly, N. L., Craik, D. J., Adams, D. J., Lewis, R. J. and Alewood, P. F. (2011). Conotoxins - blueprints for GPCR drug discovery?. 22nd American Peptide Symposium, San Diego, CA, United States, 25-30 June 2011. Hoboken, NJ, United States: John Wiley & Sons.

Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor

Muttenthaler, M. M., de Araujo, A. D., Andersson, A., Vetter, I., Gruber, C., Ramos, Y. Garcia, Feytens, D., Bergmayr, C., Freissmuth, M., Lewis, R. and Alewood, P. (2010). Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

Replacement of disulfide bonds with ditellurides: Synthesis and biological activity of ditelluro-oxytocin

Dekan, Z., Andersson, A. C., Lewis, R. J. and Alewood, P. F. (2010). Replacement of disulfide bonds with ditellurides: Synthesis and biological activity of ditelluro-oxytocin. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303

ANALGESIC omega-CONOTOXINS CVIE AND CVIF SELECTIVELY BLOCK N-TYPE CALCIUM CHANNELS IN A REVERSIBLE AND VOLTAGE-DEPENDENT MANNER

Adams, David J., Berecki, Geza, Motin, Leonid, Haythornthwaite, Alison, Lewis, Richard J., Alewood, Paul F. and Christie, Macdonald J. (2009). ANALGESIC omega-CONOTOXINS CVIE AND CVIF SELECTIVELY BLOCK N-TYPE CALCIUM CHANNELS IN A REVERSIBLE AND VOLTAGE-DEPENDENT MANNER. TOKYO: SPRINGER TOKYO.

DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN

Martin, W., Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Drinkwater, R., Stearns, L. J., Cousins, M., Gouke, R., Hughes, D., Rauck, R., Day, D., Nielsen, C. K. and Smith, M. T. (2009). DEVELOPMENT OF XEN2174: NON-CLINICAL STUDIES AND AN OPEN-LABEL I/IIa STUDY OF INTRATHECAL USE IN ONCOLOGY PATIENTS WITH MODERATE TO SEVERE PAIN. 21st American Peptide Symposium, Bloomington in, Jun 07-12, 2009. HOBOKEN: JOHN WILEY & SONS INC.

Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients

Brust, A., Colless, B., Cousins, M., Day, D., Drinkwater, R., Gouke, R., Hughes, D., Lewis, R. J., Martin, W., Nielson, C., Palant, E., Rauck, R., Schmidt, P., Smith, M. T. and Steams, L. J. (2009). Development of XEN2174 and an escalating safety and tolerability study of intrathecal use in oncology patients. Michal Lebl Peptides Breaking Away, Bloomington, Indiana, U.S.A., 7-12 June, 2009. San Diego, C.A. U.S.A.: American Peptide Society.

Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential

Lewis, R. J., Palant, E., Brust, A., Colless, B., Schmidt, P., Nielsen, C. K., Smith, M. T. and Drinkwater, R. (2008). Development of novel X-conopeptide inhibitors of the norepinephrine transporter with analgesic potential. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August, 2008.

A conopeptide view of the norepinephrine transporter (NET), an integral membrane Na+- and CI-dependent transporter.

Paczkowski, FA, Bauman, S, Sharpe, LA, Dutertre, S and Lewis, RJ (2007). A conopeptide view of the norepinephrine transporter (NET), an integral membrane Na+- and CI-dependent transporter.. 51st Annual Meeting of the Biophysical Society, Baltimore, 3-7 March 2007. Bethesda: Biophysical Society.

Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands

Ulens, Chris, Dutertre, Sebastien, Hopping, Gene, Fish, Alex, Schroeder, Christina, van Elk, Rene, Akdemir, Atilla, de Esch, Iwan, Nicke, Annette, Alewood, Paul, Lewis, Richard, Smit, August B. and Perrakis, Anastassis (2007). Structural studies of AChBP, a soluble nicotinic acetylcholine receptor homolog, in complex with novel ligands. 51st Annual Meeting of the Biophysical Society, Baltimore, MD United States, 3-7 March 2007. Cambridge, United Kingdom: Cell Press.

Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa.

Croker, Daniel, Dutertre, Sebastien, Alewood, Paul and Lewis, Richard (2006). Discovery and pharmacology of conopressin-T, a novel vasopressin-like peptide from Conus tulipa.. OXFORD: BLACKWELL PUBLISHING.

Conopeptide to drug: The development, structure and activity correlation of XEN2174

Brust, A., Alewood, D., Colless, B., Palant, E., Patterson, B., Wilson, D. T. R., Watson, F., Schroeder, C. I., Alewood, P. F. and Lewis, R. J. (2006). Conopeptide to drug: The development, structure and activity correlation of XEN2174. 29th European Peptide Symposium, Gdansk, Poland, 3-8 September, 2006,. Chichester, England: John Wiley & Sons Ltd. doi: 10.1002/psc.797

Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain

Smith, M. T., Nielsen, C. K., Hwang, J. C., Kydd, S., Wyse, B. D., Lewis, R. J. and Drinkwater, R. D. (2005). Intrathecal XEN2174 produces significant anti-allodynia in morphine-tolerant rats using the CCI-model of persistent neuropathic pain. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.

The role of group I metabotropic glutamate receptor's in neuronal excitotoxicity in Alzheimer's disease

Tsai, Vicky W. W., Scott, Heather L ., Lewis, Richard J. and Dodd, Peter R. (2005). The role of group I metabotropic glutamate receptor's in neuronal excitotoxicity in Alzheimer's disease. 1st Annual Meeting of the Australian-Dementia-and-Neurodegenerative-Diseases-Research-Group, Melbourne, Australia, 31 January, 2004. Mountain Home: F P Graham Publishing Co. doi: 10.1007/BF03033782

Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract

Smith, M. T., Nielsen, C., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic effects of Xen2174 in rats with neuropathy. Abstract. ANZCA Annual Scientific Meeting, Perth, Western Australia, 1-5 May, 2004. Australia: ANZCA.

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

Nielsen, C., Smith, M. T., Lewis, R., Alewood, D. and Drinkwater, R. D. (2004). Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. CPT2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Oxford, United Kingdom: Blackwell Scientific Publications. doi: 10.1111/j.1440-1681.2004.cep_4027.pdf.x

Differential interactions of p-TIA with human alpha(1)-adrenergic receptor (AR) subtypes

Chen, Z. J., Hague, C., Alewood, D., Lewis, R. J. and Minneman, K. (2004). Differential interactions of p-TIA with human alpha(1)-adrenergic receptor (AR) subtypes. Experimental Biology 2004 Meeting, Washington, D.C., 17th - 21st April, 2004. Bethesda, MD: Federation of American Societies for Experimental Biology.

From Omega-Conotoxins to Macrocycle Mimetics

Schroeder, CI, Nielsen, KJ, Adams, DA, Loughnan, M, Thomas, L, Bourne, GT, Smythe, ML, Alewood, PF, Craik, DJ and Lewis, RJ (2004). From Omega-Conotoxins to Macrocycle Mimetics. CHICHESTER: JOHN WILEY & SONS LTD.

Liposaccharides in peptide drug delivery

Blanchfield, J. T., Gallagher, O. P., Koda, Y., Alewood, P.F., Lewis, R. J. and Toth, I. (2004). Liposaccharides in peptide drug delivery. 18th American Peptide Symposium, Boston, 19-23 July, 2003. WASHINGTON: AMER CHEMICAL SOC.

NMDA receptor variant responses to conantokins

Ragnarsson, L. K., Yasuda, T., Adams, D. J., Lewis, R. J. and Dodd, P. R. (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of Asian-Pacific Society for Neurochemistry, Hong Kong, 4th - 7th February, 2004. Oxford, UK: Blackwell. doi: 10.1046/j.1474-1644.2003.2314p26_01.x

NMDA receptor variant responses to conantokins

Ragnarsson, L, Yasuda, T, Adams, DJ, Lewis, RJ and Dodd, PR (2004). NMDA receptor variant responses to conantokins. 6th Biennial Meeting of the Asian-Pacific-Society-for-Neurochemistry, Hong Kong Peoples R China, Feb 04-07, 2004.

The Ecotoxicology of a benthic HAB (Prorocentrum) bloom, nutrients and ciguatera, Rarotonga, Cook Islands

Skinner, M. P., Lewis, R. J., Johnstone, Ron W. and Shaw, G. R. (2004). The Ecotoxicology of a benthic HAB (Prorocentrum) bloom, nutrients and ciguatera, Rarotonga, Cook Islands. XIth International Conference on Harmful Algae, Cape Town, South Africa, 14-19 November, 2004. Amsterdam ; New York: Elsevier Science.

The epidemiology of ciguatera in Australia. The threat and the true prevalance of ciguatera fish poisoning

Oliver, L. M., Shaw, G. R., Moore, M. R., Lewis, R. J. and Seymour, J. (2003). The epidemiology of ciguatera in Australia. The threat and the true prevalance of ciguatera fish poisoning. Australian Seafood Industry Conference, Perth, 17-19 September 2003. Australia: Australian Seafood Industry.

The presence of ciguatera in Australian fish species.

Oliver, L. M., Shaw, G. R., Moore, M. R., Lewis, R. J. and Seymour, J (2003). The presence of ciguatera in Australian fish species.. Australian Seafood Industry Conference, Perth, 17-19 September 2003. Australia: Australian Seafood Industry.

Regional variation in the, pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins

Ragnarsson, L, Dodd, P and Lewis, R (2002). Regional variation in the, pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins. NEW YORK: ELSEVIER SCIENCE INC.

Affinity of omega-conotoxins and analogs for N-type calcium channels

Mould, J. A., Alewood, P. F., Lewis, R. J. and Adams, D. J. (2002). Affinity of omega-conotoxins and analogs for N-type calcium channels. Array, Bethesda, x.

Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the conopeptide, MR1A, in rats with neuropathic pain. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.

Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain

Nielsen, C., Ross, F. B., Lewis, R. J., Drinkwater, R. D. and Smith, M. T. (2002). Anti-allodynic efficacy of the x-conipeptide, MR1A, in rats with neuropathic pain. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.

Characterization of the effects of polyamines and conantokins on NMDA receptors in normal and Alzheimer disease human cortex

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Characterization of the effects of polyamines and conantokins on NMDA receptors in normal and Alzheimer disease human cortex. ISN-APSN Joint Neurochemistry Workshop, Salaya, Thailand, 28-30 November, 2002.

Conantokin probes of NMDA receptors in normal and Alzheimer disease human cerebral cortex

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Conantokin probes of NMDA receptors in normal and Alzheimer disease human cerebral cortex. Australian Neuroscience Society 22nd Annual Meeting, Sydney, 4-6 February, 2002.

Isolation of a novel conotoxin that targets alpha 7 and alpha 3 beta 2 neuronal nicotinic acetylcholine receptors

Nicke, A. C., Loughnan, M., Thomas, L., Alewood, P. F., Adams, D. J. and Lewis, R. J. (2002). Isolation of a novel conotoxin that targets alpha 7 and alpha 3 beta 2 neuronal nicotinic acetylcholine receptors. x, x, 2002. Bethesda, MD.: Cell Press for the Biophysical Society.

Regional variation in the pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2002). Regional variation in the pharmacology of NMDA receptors in normal and Alzheimer disease human cortex: Interactions with polyamines and conantokins. 8th Int Conf on Alzheimer's Disease and Related Disorders, Stockholm, 20-25 July, 2002.

Conantokins inhibit spermine-enhanced [ 3-H]MK-801 binding in normal and Alzheimer disease human cortex

Ragnarsson, L., Dodd, P. R. and Lewis, R. J. (2001). Conantokins inhibit spermine-enhanced [ 3-H]MK-801 binding in normal and Alzheimer disease human cortex. Australian Neuroscience Society 21st Annual Meeting, Brisbane, 28th - 31st January, 2001.

Functional studies of recombinant NR1 proteins in mammalian cells

Tsai, W., Huygens, F., Dodd, P. R. and Lewis, R. (2001). Functional studies of recombinant NR1 proteins in mammalian cells. Australian Neuroscience Society 21st Annual Meeting, Brisbane, 28th - 31st January, 2001.

Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2001). Inhibition of neurotransmitter release by novel w-conotoxins in rat preganglionic terminals. Physiological Society Scientific Meeting, King's College, London, 18 - 20 December, 2000. London: The Physiological Society.

Synthesis of lipo- and liposaccharide a-conotoxin MII conjugates.

Blanchfield, J. T., Dutton, J. L., Craik, D. J., Alewood, P.F., Lewis, R. J., Adams, D. J. and Toth, I. (2001). Synthesis of lipo- and liposaccharide a-conotoxin MII conjugates.. APSA Annual Conference 2001, Melbourne, Australia, 9-12 December, 2001. Melbourne, Australia: Australasian Pharmaceutical Science Association.

Synthesis of lipo- and liposacchride a-conotoxin MII conjugates

Blanchfield, J. T., Alewood, P.F., Lewis, R. J., Dutton, J. L., Craik, D. J. and Toth, I. (2001). Synthesis of lipo- and liposacchride a-conotoxin MII conjugates. World Chemistry Congress, Brisbane, Australia, 1-6 July, 2001. Royal Australian Chemical Institute.

A novel liposaccharide based system for peptide drug delivery

Adams, D. J., Alewood, P. F., Blanchfield, J. T., Lewis, R. J. and Toth, I. (2000). A novel liposaccharide based system for peptide drug delivery. The First Brisbane Biological and Organic Chemistry Symposium, Griffith University, Brisbane, 27 November. 2000.

A novel liposaccharide based system for peptide drug delivery

Blanchfield, J. T., Adams, D. J., Alewood, P. F., Lewis, R. J. and Toth, I. (2000). A novel liposaccharide based system for peptide drug delivery. The APSA 2000 Annual Conference, Newcastle, 6th - 8th December, 2000. Australia: APSA.

Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia

Smith, A. B., Schroeder, T. I. C., Lewis, R. J., Alewood, P. F. and Adams, D. J. (2000). Inhibition of neurotransmitter release by novel w-conotoxins in rat submandibular ganglia. 20th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, Melbourne, Australia, 30 January - 2 February, 2000. Australia: The Australian Neuroscience Society.

Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Development of analytical detection methodologies of ciguatoxins

Hamilton, B., Lewis, R., Chiswell, B., Moore, M. and Jones, A. (1999). Development of analytical detection methodologies of ciguatoxins. 6th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, Cairns, 13th - 17th September, 1999. Ontario: International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

Effect of conantokins on the spermine modulation of glutamate-NMDA sites in normal and Alzheimer disease human cerebral cortex

Dodd, P. R., Ragnarsson, L., Eckert, A. L., Alewood, P. F. and Lewis, R. (1999). Effect of conantokins on the spermine modulation of glutamate-NMDA sites in normal and Alzheimer disease human cerebral cortex. Joint meeting of the International Society for Neurochemistry (ISN) and the European Society for Chemistry (ESN), Berlin, Germany, 8 - 14 August, 1999. Hagerstown: Lipponcott-Raven.

HPLC/Mass Spectrometry and HPLC/MS/MS/ methods for the detection of Multiple Ciguatoxins

Lewis, R., Jones, A. and Vernoux, J. (1999). HPLC/Mass Spectrometry and HPLC/MS/MS/ methods for the detection of Multiple Ciguatoxins. 5th Indo-Pac Fish Conference, Noumea, New Caledonia, 3rd - 8th November, 1997. Paris, France: Societe Francaise Ichtyologie.

Modulatory effects of the b3 subunit on w-conotosin binding to neuronal N-Type calcium channels

Luchian, T., Lewis, R. and Adams, D. J. (1999). Modulatory effects of the b3 subunit on w-conotosin binding to neuronal N-Type calcium channels. 67th Meeting of the APPS, Newcastle, Aust., 27-29 September 1999. Aust.: Aust. Physiological and Pharmacological Society.

Spermine modulation of the glutamate NMDA site is differentially responsive to conantokins in normal and ALzheimer disease human cerebral cortex

Ragnarsson, L., Eckert, A. L., Dodd, P. R. and Lewis, R. J. (1999). Spermine modulation of the glutamate NMDA site is differentially responsive to conantokins in normal and ALzheimer disease human cerebral cortex. 19th Annual Meeting of the Australian Neuroscience Society, Hobart Convention Centre, Hobart, 31st January - 3rd February, 1999. Melbourne: Australian Neuroscience Society.

a-Conotoxin analogue, PnIA (AI0L), and a-Bungarotoxin block the same component of nicotinic ACh-Induced current in rat parasympathetic neurones

Hogg, R. C., Lewis, R. and Adams, D. J. (1999). a-Conotoxin analogue, PnIA (AI0L), and a-Bungarotoxin block the same component of nicotinic ACh-Induced current in rat parasympathetic neurones. 19th Annual Meeting of the Australian Neuroscience Society, Univ. of Tas., Hobart, Aust., 31 Jan - 03 Feb, 1999. Aust.: Aust. Neuroscience Society.

Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry

Jones, A, Bingham, JP, Gehrmann, J, Bond, T, Loughnan, M, Atkins, A, Lewis, RJ and Alewood, PF (1996). Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. 15th Conference of the Australian-and-New-Zealand-Society-for-Mass-Spectrometry (ANZSMS-15) - Mass Spectrometry in the 90s, Sydney Australia, Sep 24-29, 1995. W SUSSEX: JOHN WILEY & SONS LTD. doi: 10.1002/(SICI)1097-0231(19960115)10:1<138::AID-RCM442>3.0.CO;2-3