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ASAP-NMR: A leap forward in structural studies of proteins using NMR spectroscopy (2012–2016)

Abstract:
Nuclear magnetic resonance (NMR) is the only method that enables study of the structure of proteins in solution at atomic resolution. However, its use has been limited by its low throughput relative to X-ray crystallography. I have developed substantially faster methods for NMR data acquisition and I now propose to fully automate the protein structure determination process using NMR so that solution structures can be determined in less than 1 week. I will apply my method to study disulfide-rich proteins isolated from animal venoms, a proven source of drug and insecticide leads for which limited structural data is available. This will yield novel 3D structures with unprecedented precision and allow the engineering of new bioactive peptides.
Grant type:
ARC Future Fellowships
Researchers:

  • Professor Mehdi Mobli

    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Associate Professor
    Institute for Molecular Bioscience
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council