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Unravelling the structural complexity of ancient Australian arthropod venoms (2014–2017)

Abstract:
Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Mehdi Mobli

    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Associate Professor
    Institute for Molecular Bioscience
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council