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A new source of bivalent molecules from nature (2019–2022)

Abstract:
Multivalency is a key feature of molecular interaction in biology, underlying the high specificity and potency found in many proteins. This project will describe a new class of naturally occurring multivalent molecules termed "secreted cysteine-rich repeat proteins" (SCREPs). Focusing on bivalent peptides, the project will generate a database of bioactive SCREPs with similarity to known bioactive peptides, and develop new recombinant methods for their production. Advanced nuclear magnetic resonance (NMR) spectroscopy will be used to characterise members of this new class, providing new insights into the design of bivalent peptides and establishing a new source of molecules with applications in the rapidly growing biotechnology sector.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Mehdi Mobli

    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Associate Professor
    Institute for Molecular Bioscience
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council