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Autocyclases: A new class of self-cyclising proteins (2022–2025)

Abstract:
The biotechnology sector is emerging as an important economic strength in Australia. While the improved efficacy and selectivity of biomolecules has seen them emerge as alternatives to existing chemicals in health and agriculture, the stability of biomolecules remains a major limiting factor. A general strategy for improving protein stability is by joining the ends of the peptide chain in a cyclisation reaction. While a wide range of cyclic peptides and proteins are being developed in Australia and around the world, the cyclisation reaction presents a significant challenge. In this proposal we detail a novel method for protein cyclisation as a general, low-cost and green production method for making a diverse range of biomolecules.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Mehdi Mobli

    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate Associate Professor
    Institute for Molecular Bioscience
    Affiliate Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council