Dr Larisa Labzin

UQ Amplify Fellow

Institute for Molecular Bioscience
l.labzin@uq.edu.au
+61 7 344 36177

Overview

Dr. Larisa Labzin studies how our innate immune system detects viral infections and how it decodes different signals to mount an appropriate immune response. Dr. Labzin's interest in innate immunity started during her honours training with Prof. Matt Sweet at the IMB, looking at how inflammatory signalling is regulated in macrophages. After gaining more experience while working as a research assistant for Prof. Sweet, she moved to Germany to the University of Bonn for her PhD. At the Univeristy of Bonn, Dr. Labzin investigated the anti-inflammatory effects of High-Density Lipoprotein with Prof. Eicke Latz. Here she discovered novel regulatory pathways that control inflammation. Dr. Labzin then moved to Cambridge, UK as an EMBO postdoctoral fellow to work with Dr. Leo James at the Medical Research Council Laboratory for Molecular Biology. In Dr. James' lab Dr. Labzin focused on how viruses are sensed by the innate immune system to trigger inflammation. In particular, Dr Labzin investigated how antibodies change the way viruses trigger inflammation. While in Cambridge, Dr. Labzin was awarded an NHMRC CJ Martin Fellowship to return to Australia. Larisa returned to the IMB in September 2019 to work with Prof. Kate Schroder. Dr. Labzin is an IMB Fellow and leads an independent research team studying inflammation in response to influenza and SARS-CoV-2.

Research Interests

  • How antibodies modulate innate immune sensing
    Innate sensing of viruses is studied mainly in the context of naive infection. We want to understand how pre-existing immunity, in the form of antibodies, changes the inflammatory response to viruses.
  • Human macrophage responses to viruses
    Viruses trigger strong inflammatory responses. We are studying the molecular pathways in human macrophages that are triggered during viral infection
  • Conservation of Innate Immunity across species
    Many species are important viral reservoirs. Yet little is understood about innate immunity in these species. We are studying key innate pathways signal in non-human species.
  • How innate immune cells respond to dying cells
    Many cells die during infection. How innate immune cells sense cell damage and respond accordingly is poorly understood. We are studying how cells interpret signs of danger to mount an effective immune response

Research Impacts

Dr. Labzin is heavily involved in public outreach and in communicating immunology to the wider public. Dr Labzin explains how the immune system works, how vaccines work and attempts to encourage vaccine uptake. Dr Labzin's research is elucidating how the immune system contributes to disease during viral infection. Key to this is understanding why different people respond differently to viral infections. Dr Labzin's research aims to identify new pathways to target, so that we can best treat viral infections, reducing sick days, symptoms and serious complications.

Qualifications

  • UV - Doctor of Philosophy, Rheinish-Westphalian Technical University

Publications

  • Yordanov, Teodor E., Keyser, Mikaela S., Enriquez Martinez, Marco A., Esposito, Tyron, Tefft, Juliann B., Morris, Elysse K., Labzin, Larisa I., Stehbens, Samantha J., Rowan, Alan E., Hogan, Benjamin M., Chen, Christopher S., Lauko, Jan and Lagendijk, Anne K. (2024). Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioengineering, 8 (1). doi: 10.1063/5.0159330

  • Chan, Amy H., Burgener, Sabrina S., Vezyrgiannis, Kassandra, Wang, Xiaohui, Acklam, Jadie, Von Pein, Jessica B., Pizzuto, Malvina, Labzin, Larisa I., Boucher, Dave and Schroder, Kate (2023). Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme. Life Science Alliance, 6 (10) e202301908, 1-11. doi: 10.26508/lsa.202301908

  • Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

View all Available Projects

Publications

Book Chapter

  • Lauterbach, Mario A. R., Labzin, Larisa I. and Latz, Eicke (2017). Inflammation in atherosclerosis. Inflammation - from molecular and cellular mechanisms to the clinic. (pp. 1279-1300) Weinheim, Germany: Wiley. doi: 10.1002/9783527692156.ch49

  • De Nardo, Dominic, Vogelhuber, Johanna, Labzin, Larisa, Langhoff, Pia and Latz, Eicke (2012). Inflammasomopathies: diseases linked to the NLRP3 inflammasome. New-opathies: an emerging molecular reclassification of human disease. (pp. 23-65) edited by Errol C. Friedberg, Diego H. Castrillon, Rene L. Galindo and Keith Wharton. Singapore: World Scientific. doi: 10.1142/9789814355698_0002

Journal Article

  • Yordanov, Teodor E., Keyser, Mikaela S., Enriquez Martinez, Marco A., Esposito, Tyron, Tefft, Juliann B., Morris, Elysse K., Labzin, Larisa I., Stehbens, Samantha J., Rowan, Alan E., Hogan, Benjamin M., Chen, Christopher S., Lauko, Jan and Lagendijk, Anne K. (2024). Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioengineering, 8 (1). doi: 10.1063/5.0159330

  • Chan, Amy H., Burgener, Sabrina S., Vezyrgiannis, Kassandra, Wang, Xiaohui, Acklam, Jadie, Von Pein, Jessica B., Pizzuto, Malvina, Labzin, Larisa I., Boucher, Dave and Schroder, Kate (2023). Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme. Life Science Alliance, 6 (10) e202301908, 1-11. doi: 10.26508/lsa.202301908

  • Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

  • Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3), e0081523. doi: 10.1128/mbio.00815-23

  • Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3), e0016523. doi: 10.1128/msphere.00165-23

  • Labzin, Larisa I. and Schroder, Kate (2023). Stoking inflammasome fires in the COVID-19 neighborhood. Cell Host and Microbe, 31 (2), 168-170. doi: 10.1016/j.chom.2023.01.008

  • Wang, Xiaohui and Labzin, Larisa I. (2023). Inflammatory cell death: how macrophages sense neighbouring cell infection and damage. Biochemical Society Transactions, 51 (1), 303-313. doi: 10.1042/bst20220807

  • Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97 (5). doi: 10.1128/jvi.00451-23

  • Zhu, Yanshan, Chew, Keng Yih, Wu, Melanie, Karawita, Anjana C., McCallum, Georgina, Steele, Lauren E., Yamamoto, Ayaho, Labzin, Larisa I., Yarlagadda, Tejasri, Khromykh, Alexander A., Wang, Xiaohui, Sng, Julian D. J., Stocks, Claudia J., Xia, Yao, Kollmann, Tobias R., Martino, David, Joensuu, Merja, Meunier, Frédéric A., Balistreri, Giuseppe, Bielefeldt-Ohmann, Helle, Bowen, Asha C., Kicic, Anthony, Sly, Peter D., Spann, Kirsten M. and Short, Kirsty R. (2022). Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells. PLoS Biology, 20 (8) e3001728, 1-19. doi: 10.1371/journal.pbio.3001728

  • Hulme, Katina D., Noye, Ellesandra C., Short, Kirsty R. and Labzin, Larisa I. (2021). Dysregulated inflammation during obesity: driving disease severity in influenza virus and SARS-CoV-2 infections. Frontiers in Immunology, 12 770066, 770066. doi: 10.3389/fimmu.2021.770066

  • Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350

  • Labzin, Larisa I., Bottermann, Maria, Rodriguez‐Silvestre, Pablo, Foss, Stian, Andersen, Jan Terje, Vaysburd, Marina, Clift, Dean and James, Leo C. (2019). Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal, 38 (21) e101365, e101365. doi: 10.15252/embj.2018101365

  • Castro-Dopico, Tomas, Dennison, Thomas W., Ferdinand, John R., Mathews, Rebeccah J., Fleming, Aaron, Clift, Dean, Stewart, Benjamin J., Jing, Chenzhi, Strongili, Konstantina, Labzin, Larisa I., Monk, Edward J.M., Saeb-Parsy, Kourosh, Bryant, Clare E., Clare, Simon, Parkes, Miles and Clatworthy, Menna R. (2019). Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity, 50 (4), 1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006

  • Labzin, Larisa I., Heneka, Michael T. and Latz, Eicke (2018). Innate immunity and neurodegeneration. Annual Review of Medicine, 69 (1), 437-449. doi: 10.1146/annurev-med-050715-104343

  • Clift, Dean, McEwan, William A., Labzin, Larisa I., Konieczny, Vera, Mogessie, Binyam, James, Leo C. and Schuh, Melina (2017). A method for the acute and rapid degradation of endogenous proteins. Cell, 171 (7), 1692-1706. doi: 10.1016/j.cell.2017.10.033

  • Labzin, Larisa I., Lauterbach, Mario A.R. and Latz, Eicke (2016). Interferons and inflammasomes: cooperation and counterregulation in disease. Journal of Allergy and Clinical Immunology, 138 (1), 37-46. doi: 10.1016/j.jaci.2016.05.010

  • Zimmer, Sebastian, Grebe, Alena, Bakke, Siril S., Bode, Niklas, Halvorsen, Bente, Ulas, Thomas, Skjelland, Mona, De Nardo, Dominic, Labzin, Larisa I., Kerksiek, Anja, Hempel, Chris, Heneka, Michael T., Hawxhurst, Victoria, Fitzgerald, Michael L., Trebicka, Jonel, Björkhem, Ingemar, Gustafsson, Jan-Åke, Westerterp, Marit, Tall, Alan R., Wright, Samuel D., Espevik, Terje, Schultze, Joachim L., Nickenig, Georg, Lütjohann, Dieter and Latz, Eicke (2016). Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine, 8 (333) ra50, 333ra50-333ra50. doi: 10.1126/scitranslmed.aad6100

  • Labzin, Larisa I., Schmidt, Susanne V., Masters, Seth L., Beyer, Marc, Krebs, Wolfgang, Klee, Kathrin, Stahl, Rainer, Lütjohann, Dieter, Schultze, Joachim L., Latz, Eicke and De Nardo, Dominic (2015). ATF3 is a key regulator of macrophage IFN responses. Journal of Immunology, 195 (9), 4446-4455. doi: 10.4049/jimmunol.1500204

  • Krebs, Wolfgang, Schmidt, Susanne V., Goren, Alon, De Nardo, Dominic, Labzin, Larisa, Bovier, Anton, Ulas, Thomas, Theis, Heidi, Kraut, Michael, Latz, Eicke, Beyer, Marc and Schultze, Joachim L. (2014). Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research, 42 (21), 13051-13060. doi: 10.1093/nar/gku1078

  • Xue, Jia, Schmidt, Susanne V., Sander, Jil, Draffehn, Astrid, Krebs, Wolfgang, Quester, Inga, DeNardo, Dominic, Gohel, Trupti D., Emde, Martina, Schmidleithner, Lisa, Ganesan, Hariharasudan, Nino-Castro, Andrea, Mallmann, Michael R., Labzin, Larisa, Theis, Heidi, Kraut, Michael, Beyer, Marc, Latz, Eicke, Freeman, Tom C., Ulas, Thomas and Schultze, Joachim L. (2014). Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity, 40 (2), 274-288. doi: 10.1016/j.immuni.2014.01.006

  • De Nardo, Dominic, Labzin, Larisa I., Kono, Hajime, Seki, Reiko, Schmidt, Susanne V., Beyer, Marc, Xu, Dakang, Zimmer, Sebastian, Lahrmann, Catharina, Schildberg, Frank A., Vogelhuber, Johanna, Kraut, Michael, Ulas, Thomas, Kerksiek, Anja, Krebs, Wolfgang, Bode, Niklas, Grebe, Alena, Fitzgerald, Michael L., Hernandez, Nicholas J., Williams, Bryan R.G., Knolle, Percy, Kneilling, Manfred, Röcken, Martin, Lütjohann, Dieter, Wright, Samuel D., Schultze, Joachim L. and Latz, Eicke (2014). High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology, 15 (2), 152-160. doi: 10.1038/ni.2784

  • Pelka, Karin, Phulphagar, Kshiti, Zimmermann, Jana, Stahl, Rainer, Schmid-Burgk, Jonathan L., Schmidt, Tobias, Spille, Jan-Hendrik, Labzin, Larisa I., Agrawal, Sudhir, Kandimalla, Ekambar R., Casanova, Jean-Laurent, Hornung, Veit, Marshak-Rothstein, Ann, Höning, Stefan and Latz, Eicke (2014). Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms. Journal of Immunology, 193 (7), 3257-3261. doi: 10.4049/jimmunol.1301886

  • Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

  • Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109

  • Christ, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a

  • Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

PhD and MPhil Supervision

Current Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.