The University of Queensland

Advances in the Development of Artificial Metalloenzymes

Parac-Vogt, Tatjana N., Erxleben, Andrea, Schenk, Gerhard and Prabhakar, Rajeev eds. (2019). Advances in the Development of Artificial Metalloenzymes. Frontiers Research Topics, Lausanne, Switzerland: Frontiers Research Foundation. doi: 10.3389/978-2-88963-153-7

Catalytic mechanisms of metallohydrolases containing two metal ions

Mitić, Nataša, Miraula, Manfredi, Selleck, Christopher, Hadler, Kieran S., Uribe, Elena, Pedroso, M. M. and Schenk, G. (2014). Catalytic mechanisms of metallohydrolases containing two metal ions. Metal-containing enzymes. (pp. 49-81) edited by Christo Z. Christov. Waltham, MA, United States: Academic Press. doi: 10.1016/bs.apcsb.2014.07.002

Manganese Metalloproteins

Smith, Sarah J., Hadler, Kieran S., Schenk, Gerhard, Hanson, Graeme R. and Mitic, Nataša (2010). Manganese Metalloproteins. Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes. (pp. 273-341) edited by Graeme Hanson and Lawrence Berliner. New York, USA: Springer. doi: 10.1007/978-1-4419-1139-1_9

Binuclear non-heme iron enzymes

Mitić, Nataša, Schenk, Gerhard and Hanson, Graeme R. (2009). Binuclear non-heme iron enzymes. High resolution EPR: applications to metalloenzymes and metals in medicine. (pp. 269-395) edited by Graeme Hanson and Lawrence Berliner. New York, NY, United States: Springer. doi: 10.1007/978-0-387-84856-3_7

Magnetic circular dichroism of paramagnetic species

Solomon, E. I., Neidig, M. L. and Schenk, G. (2004). Magnetic circular dichroism of paramagnetic species. Comprehensive coordination chemistry II: From biology to nanotechnology. (pp. 339-349) edited by J. A. McCleverty and T. J.Meyer. Oxford, U.K.: Elsevier/Pergamon. doi: 10.1016/B0-08-043748-6/01216-0

Site-directed mutagenesis of E50, F496 and H113 in Zymomonas mobilis decarboxylase

Candy, Judith, Nixon, Peter, England, Renee, Schenk, Gerhard, Koga, J. and Duggleby, Ronald (1996). Site-directed mutagenesis of E50, F496 and H113 in Zymomonas mobilis decarboxylase. Biochemistry and physiology of thiamin diphosphate enzymes . (pp. 82-102) Prien, Germany: A. and C. Intemann, Wissenschaftlicher .

Improving the Catalytic Efficiency of a GH5 Processive Endoglucanase by a Combinatorial Strategy Using Consensus Mutagenesis and Loop Engineering

Lv, Kemin, Li, Xiaozhou, Chen, Kequan, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Improving the Catalytic Efficiency of a GH5 Processive Endoglucanase by a Combinatorial Strategy Using Consensus Mutagenesis and Loop Engineering. ACS Catalysis, 6856-6867. doi: 10.1021/acscatal.4c01083

Mapping of the Reaction Trajectory Catalyzed by Class I Ketol-Acid Reductoisomerase

Lin, Xin, Lonhienne, Thierry, Lv, You, Kurz, Julia L., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2024). Mapping of the Reaction Trajectory Catalyzed by Class I Ketol-Acid Reductoisomerase. ACS Catalysis, 6827-6841. doi: 10.1021/acscatal.4c00958

Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzl, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, Harmer, Jeffrey R., Tyson, Gene, Clark, Alice, Schenk, Gerhard and Bernhardt, Paul V. (2024). Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry 112539, 1-10. doi: 10.1016/j.jinorgbio.2024.112539

Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity

Dinda, Rupam, Mohanty, Monalisa, Wilson, Liam, Roy, Satabdi, Mohapatra, Deepika, Patra, Sushree Aradhana, Schenk, Gerhard, Pessoa, João Costa, Sasamori, Takahiro and Aurelien, Crochet (2024). Synthesis, Characterization, and Structures of Mononuclear and Phenoxo-/Acetato-Bridged Trinuclear Zinc(II) Complexes from Salan Ligands: Study of their Hydrolytic Activity. Journal of Molecular Structure, 1308 138106, 138106. doi: 10.1016/j.molstruc.2024.138106

Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology

Huang, Xiao-Lan, Harmer, Jeffrey R., Schenk, Gerhard and Southam, Gordon (2024). Inorganic Fe-O and Fe-S oxidoreductases: paradigms for prebiotic chemistry and the evolution of enzymatic activity in biology. Frontiers in Chemistry, 12 ARTN 1349020. doi: 10.3389/fchem.2024.1349020

Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines

Wang, Jialing, Huang, Zhuangzhuang, Xu, Haodong, Nian, Yong, Wu, Bin, He, Bingfang and Schenk, Gerhard (2024). Discovery and mechanistic understanding of a lipase from Rhizorhabdus dicambivorans for efficient ester aminolysis in aromatic amines. ChemSusChem. doi: 10.1002/cssc.202301735

Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem

Lv, Kemin, Cao, Xuefei, Pedroso, Marcelo Monteiro, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2024). Structure-guided engineering of branched-chain α-keto acid decarboxylase for improved 1,2,4-butanetriol production by in vitro synthetic enzymatic biosystem. International Journal of Biological Macromolecules, 255 128303, 1-12. doi: 10.1016/j.ijbiomac.2023.128303

Development of a Highly Selective NAD+‐Dependent Glyceraldehyde Dehydrogenase and its Application in Minimal Cell‐Free Enzyme Cascades

Teshima, Mariko, Sutiono, Samuel, Döring, Manuel, Beer, Barbara, Boden, Mikael, Schenk, Gerhard and Sieber, Volker (2023). Development of a Highly Selective NAD+‐Dependent Glyceraldehyde Dehydrogenase and its Application in Minimal Cell‐Free Enzyme Cascades. ChemSusChem, e202301132. doi: 10.1002/cssc.202301132

Realising the circular phosphorus economy delivers for sustainable development goals

Walsh, Michael, Schenk, Gerhard and Schmidt, Susanne (2023). Realising the circular phosphorus economy delivers for sustainable development goals. npj Sustainable Agriculture, 1 (1) 2, 1-15. doi: 10.1038/s44264-023-00002-0

Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization

Cheah, Li Chen, Liu, Lian, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Vickers, Claudia E. and Sainsbury, Frank (2023). Product Profiles of Promiscuous Enzymes Can be Altered by Controlling In Vivo Spatial Organization. Advanced Science, 10 (32) 2303415, e2303415. doi: 10.1002/advs.202303415

Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

Kurz, Julia L., Monteiro Pedroso, Marcelo, Richard, Emmanuelle, McGeary, Ross P. and Schenk, Gerhard (2023). Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorganic and Medicinal Chemistry Letters, 92 129387, 1-5. doi: 10.1016/j.bmcl.2023.129387

Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance

Krco, Stefan, Davis, Samuel J., Joshi, Pallav, Wilson, Liam A., Monteiro Pedroso, Marcelo, Douw, Andrew, Schofield, Christopher J., Hugenholtz, Philip, Schenk, Gerhard and Morris, Marc T. (2023). Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance. Frontiers in Chemistry, 11 1196073, 1196073. doi: 10.3389/fchem.2023.1196073

Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches

Feder, Daniel, Mohd-Pahmi, Siti Hajar, Adibi, Hadi, Guddat, Luke W., Schenk, Gerhard, McGeary, Ross P. and Hussein, Waleed M. (2023). Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. European Journal of Medicinal Chemistry, 254 115383, 1-19. doi: 10.1016/j.ejmech.2023.115383

Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation

Cheah, Li Chen, Liu, Lian, Stark, Terra, Plan, Manuel R., Peng, Bingyin, Lu, Zeyu, Schenk, Gerhard, Sainsbury, Frank and Vickers, Claudia E. (2023). Metabolic flux enhancement from the translational fusion of terpene synthases is linked to terpene synthase accumulation. Metabolic Engineering, 77, 143-151. doi: 10.1016/j.ymben.2023.03.012

Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase

Cheng, Yan, Lonhienne, Thierry, Garcia, Mario. D., Williams, Craig M., Schenk, Gerard and Guddat, Luke W. (2023). Crystal structure of the commercial herbicide, amidosulfuron, in complex with Arabidopsis thaliana acetohydroxyacid synthase. Journal of Agricultural and Food Chemistry, 71 (13), 5117-5126. doi: 10.1021/acs.jafc.2c08528

Gas fermentation for microbial sustainable aviation fuel production

Rodriguez, Karen, Pedroso, Marcelo, Harris, Audrey, Garg, Shivani, Hine, Damian, Köpke, Michael, Schenk, Gerhard and Marcellin, Esteban (2023). Gas fermentation for microbial sustainable aviation fuel production. Microbiology Australia, 44 (1), 31-35. doi: 10.1071/ma23008

Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes

Jayasinghe-Arachchige, Vindi M., Serafim, Leonardo F., Hu, Qiaoyu, Ozen, Cihan, Moorkkannur, Sreerag N., Schenk, Gerhard and Prabhakar, Rajeev (2023). Elucidating the roles of distinct chemical factors in the hydrolytic activities of hetero- and homonuclear synthetic analogues of binuclear metalloenzymes. ACS Catalysis, 13 (5), 3131-3147. doi: 10.1021/acscatal.2c05758

Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus

Bayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140

Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand

Costa, Luel M.O., Reis, Iago S., Fernandes, Christiane, Marques, Marcelo M., Resende, Jackson A.L.C., Krenske, Elizabeth H., Schenk, Gerhard, Gahan, Lawrence R. and Horn, Adolfo (2023). Synthesis, characterization and computational investigation of the phosphatase activity of a dinuclear Zinc(II) complex containing a new heptadentate asymmetric ligand. Journal of Inorganic Biochemistry, 239 112064, 1-13. doi: 10.1016/j.jinorgbio.2022.112064

Biomimetics for purple acid phosphatases: a historical perspective

Wilson, Liam A., Pedroso, Marcelo M., Peralta, Rosely A., Gahan, Lawrence R. and Schenk, Gerhard (2023). Biomimetics for purple acid phosphatases: a historical perspective. Journal of Inorganic Biochemistry, 238 112061, 112061. doi: 10.1016/j.jinorgbio.2022.112061

Structural basis of resistance to herbicides that target acetohydroxyacid synthase

Lonhienne, Thierry, Cheng, Yan, Garcia, Mario D., Hu, Shu Hong, Low, Yu Shang, Schenk, Gerhard, Williams, Craig M. and Guddat, Luke W. (2022). Structural basis of resistance to herbicides that target acetohydroxyacid synthase. Nature Communications, 13 (1) 3368, 3368. doi: 10.1038/s41467-022-31023-x

Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase

Satta, Alessandro, Esquirol, Lygie, Ebert, Birgitta E., Newman, Janet, Peat, Thomas S., Plan, Manuel, Schenk, Gerhard and Vickers, Claudia E. (2022). Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase. The FEBS Journal, 289 (21), 6672-6693. doi: 10.1111/febs.16556

Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes

Cheah, L. C., Liu, L., Plan, M. R., Peng, B., Lu, Z., Schenk, G., Vickers, C. E. and Sainsbury, F. (2022). Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes. BioRxiv. doi: 10.1101/2022.11.24.517869

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Foley, Gabriel, Mora, Ariane, Ross, Connie M., Bottoms, Scott, Sützl, Leander, Lamprecht, Marnie L., Zaugg, Julian, Essebier, Alexandra, Balderson, Brad, Newell, Rhys, Thomson, Raine E. S., Kobe, Bostjan, Barnard, Ross T., Guddat, Luke, Schenk, Gerhard, Carsten, Jörg, Gumulya, Yosephine, Rost, Burkhard, Haltrich, Dietmar, Sieber, Volker, Gillam, Elizabeth M. J. and Bodén, Mikael (2022). Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP). PL o S Computational Biology, 18 (10) e1010633, e1010633. doi: 10.1371/journal.pcbi.1010633

Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals

Lv, You, Zheng, Shan, Goldenzweig, Adi, Liu, Fengjiang, Gao, Yan, Yang, Xiuna, Kandale, Ajit, McGeary, Ross P., Williams, Simon, Kobe, Bostjan, Schembri, Mark A., Landsberg, Michael J., Wu, Bin, Brück, Thomas B., Sieber, Volker, Boden, Mikael, Rao, Zihe, Fleishman, Sarel J., Schenk, Gerhard and Guddat, Luke W. (2022). Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals. Applied Biosciences, 1 (2), 163-178. doi: 10.3390/applbiosci1020011

Metabolomics of non-saccharomyces yeasts in fermented beverages

Ellis, Daniel J., Kerr, Edward D., Schenk, Gerhard and Schulz, Benjamin L. (2022). Metabolomics of non-saccharomyces yeasts in fermented beverages. Beverages, 8 (3) 41, 1-14. doi: 10.3390/beverages8030041

Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genome-guided analysis of seven weed species reveals conserved sequence and structural features of key gene targets for herbicide development. Frontiers in Plant Science, 13 909073. doi: 10.3389/fpls.2022.909073

Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance

Bayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, e202200927. doi: 10.1002/chem.202200927

Efficient green light acclimation of the green algae Picochlorum sp. triggering geranylgeranylated chlorophylls

Paper, Michael, Glemser, Matthias, Haack, Martina, Lorenzen, Jan, Mehlmer, Norbert, Fuchs, Tobias, Schenk, Gerhard, Garbe, Daniel, Weuster-Botz, Dirk, Eisenreich, Wolfgang, Lakatos, Michael and Brueck, Thomas B. (2022). Efficient green light acclimation of the green algae Picochlorum sp. triggering geranylgeranylated chlorophylls. Frontiers in Bioengineering and Biotechnology, 10 885977. doi: 10.3389/fbioe.2022.885977

Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol

Ringel, Marion, Dimos, Nicole, Himpich, Stephanie, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Schenk, Gerhard, Loll, Bernhard and Brück, Thomas (2022). Biotechnological potential and initial characterization of two novel sesquiterpene synthases from Basidiomycota Coniophora puteana for heterologous production of δ-cadinol. Microbial Cell Factories, 21 (1) 64, 64. doi: 10.1186/s12934-022-01791-8

Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratases

Melse, Okke, Sutiono, Samuel, Haslbeck, Magdalena, Schenk, Gerhard, Antes, Iris and Sieber, Volker (2022). Structure‐guided modulation of the catalytic properties of [2Fe‐2S]‐dependent dehydratases. ChemBioChem, 23 (10) e202200088, e202200088. doi: 10.1002/cbic.202200088

LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibiotics

Stroek, Rozanne, Wilson, Liam, Goracke, William, Kang, Taeuk, Vermue, Febe, Krco, Stefan, Mendels, Yonatan, Douw, Andrew, Morris, Marc, Knaven, Esmee G., Mitić, Nataša, Gutierrez, Maria C.R., Schenk, Elaine B., Clark, Alice, Garcia, David, Monteiro Pedroso, Marcelo and Schenk, Gerhard (2022). LAM-1 from Lysobacter antibioticus: a potent zinc-dependent activity that inactivates β-lactam antibiotics. Journal of Inorganic Biochemistry, 226 111637, 1-4. doi: 10.1016/j.jinorgbio.2021.111637

Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads

Low, Y. S., Garcia, M. D., Lonhienne, T., Fraser, J. A., Schenk, G. and Guddat, L. W. (2021). Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports, 11 (1) 21055. doi: 10.1038/s41598-021-00349-9

Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid

Wilson, Liam A., Knaven, Esmée G., Morris, Marc T., Monteiro Pedroso, Marcelo, Schofield, Christopher J., Brück, Thomas, Boden, Mikael, Waite, David W., Hugenholtz, Philip, Guddat, Luke and Schenk, Gerhard (2021). Kinetic and structural characterization of the first B3 metallo-β-lactamase with an active site glutamic acid. Antimicrobial Agents and Chemotherapy, 65 (10) e00936-21, e0093621. doi: 10.1128/aac.00936-21

Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis

Wang, Lijuan, Cao, Kun, Pedroso, Marcelo Monteiro, Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Sequence- and structure-guided improvement of the catalytic performance of a GH11 family xylanase from Bacillus subtilis. Journal of Biological Chemistry, 297 (5) 101262, 101262. doi: 10.1016/j.jbc.2021.101262

Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach

Feder, Daniel, Mohd-Pahmi, Siti H., Hussein, Waleed M., Guddat, Luke W., McGeary, Ross P. and Schenk, Gerhard (2021). Rational design of potent inhibitors of a metallohydrolase using a fragment-based approach. ChemMedChem, 16 (21) cmdc.202100486, 3342-3359. doi: 10.1002/cmdc.202100486

Land and sea: addressing the challenges facing inter-regional ecosystems in developing a sustainable bioeconomy

O'Hara, Ian M., Tanticharoen, Morakot, MacRae, Elspeth, Imbrogno, Anthony, Rossi, Teresa, Sieber, Volker, Schenk, Gerhard, Ann-Kathrin, Kaufmann, Lukic, Ivana and Satapoomin, Ukkrit (2021). Land and sea: addressing the challenges facing inter-regional ecosystems in developing a sustainable bioeconomy. EFB Bioeconomy Journal, 1 100017, 1-4. doi: 10.1016/j.bioeco.2021.100017

Metal affinity immobilization of the processive endoglucanase EG5C-1 from Bacillus subtilis on a recyclable pH-responsive polymer

Lv, Kemin, Yu, Zhimeng, Pedroso, Marcelo M., Wu, Bin, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2021). Metal affinity immobilization of the processive endoglucanase EG5C-1 from Bacillus subtilis on a recyclable pH-responsive polymer. ACS Sustainable Chemistry and Engineering, 9 (23) acssuschemeng.1c02215, 7948-7959. doi: 10.1021/acssuschemeng.1c02215

Pesticide degradation by immobilised metalloenzymes provides an attractive avenue for bioremediation

Pedroso, Marcelo Monteiro, Hine, Damian, Hahn, Sebastian, Chmielewicz, Wioleta Monika, Diegel, Janika, Gahan, Lawrence and Schenk, Gerhard (2021). Pesticide degradation by immobilised metalloenzymes provides an attractive avenue for bioremediation. EFB Bioeconomy Journal, 1 100015, 1-8. doi: 10.1016/j.bioeco.2021.100015

Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase

Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665

Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesis

Lv, Kemin, Shao, Wenyu, Pedroso, Marcelo Monteiro, Peng, Jiayu, Wu, Bin, Li, Jiahuang, He, Bingfang and Schenk, Gerhard (2021). Enhancing the catalytic activity of a GH5 processive endoglucanase from Bacillus subtilis BS-5 by site-directed mutagenesis. International Journal of Biological Macromolecules, 168, 442-452. doi: 10.1016/j.ijbiomac.2020.12.060

Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads

Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919

Recent advances in heterogeneous catalytic systems containing metal ions for phosphate ester hydrolysis

Gomes, Marco Antonio G. B., Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo (2021). Recent advances in heterogeneous catalytic systems containing metal ions for phosphate ester hydrolysis. Chemistry: A European Journal, 27 (3) chem.202002333, 877-887. doi: 10.1002/chem.202002333

Dinuclear copper(II) complexes with derivative triazine ligands as biomimetic models for catechol oxidases and nucleases

Silva, Marcos P., Saibert, Cristine, Bortolotto, Tiago, Bortoluzzi, Adailton J., Schenk, Gerhard, Peralta, Rosely A., Terenzi, Hernán and Neves, Ademir (2020). Dinuclear copper(II) complexes with derivative triazine ligands as biomimetic models for catechol oxidases and nucleases. Journal of Inorganic Biochemistry, 213 111249, 111249. doi: 10.1016/j.jinorgbio.2020.111249

Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms

Selleck, Christopher, Pedroso, Marcelo Monteiro, Wilson, Liam, Krco, Stefan, Knaven, Esmée Gianna, Miraula, Manfredi, Mitić, Nataša, Larrabee, James A., Brück, Thomas, Clark, Alice, Guddat, Luke W. and Schenk, Gerhard (2020). Structure and mechanism of potent bifunctional β-lactam- and homoserine lactone-degrading enzymes from marine microorganisms. Scientific Reports, 10 (1) 12882, 12882. doi: 10.1038/s41598-020-68612-z

Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms

Wun, Shun Jie, Johnson, Lambro A., You, Lv, McGeary, Ross P., Brueck, Thomas, Schenk, Gerhard and Guddat, Luke W. (2020). Inhibition studies of ketol-acid reductoisomerases from pathogenic microorganisms. Archives of Biochemistry and Biophysics, 692 108516, 108516. doi: 10.1016/j.abb.2020.108516

Towards a sustainable generation of pseudopterosin-type bioactives

Ringel, Marion, Reinbold, Markus, Hirte, Max, Haack, Martina, Huber, Claudia, Eisenreich, Wolfgang, Masri, Mahmoud A., Schenk, Gerhard, Guddat, Luke W., Loll, Bernhard, Kerr, Russell, Garbe, Daniel and Brück, Thomas (2020). Towards a sustainable generation of pseudopterosin-type bioactives. Green Chemistry, 22 (18), 6033-6046. doi: 10.1039/d0gc01697g

Structures of fungal and plant acetohydroxyacid synthases

Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3

Towards high-throughput optimization of microbial lipid production: from strain development to process monitoring

Awad, Dania, Younes, Samer, Glemser, Matthias, Wagner, Franz M., Schenk, Gerhard, Mehlmer, Norbert and Brueck, Thomas (2020). Towards high-throughput optimization of microbial lipid production: from strain development to process monitoring. Sustainable Energy and Fuels, 4 (12), 5958-5969. doi: 10.1039/d0se00540a

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse

Pedroso, Marcelo Monteiro, Waite, David W., Melse, Okke, Wilson, Liam, Mitić, Nataša, McGeary, Ross P., Antes, Iris, Guddat, Luke W., Hugenholtz, Philip and Schenk, Gerhard (2020). Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse. Protein and Cell, 11 (8), 613-617. doi: 10.1007/s13238-020-00736-4

Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction

Wilson, Liam A., Garcia, David, Pedroso, Marcelo Monteiro, Schulz, Benjamin L., Guddat, Luke W. and Schenk, Gerhard (2020). Adaptation of a continuous, calorimetric kinetic assay to study the agmatinase-catalyzed hydrolytic reaction. Analytical Biochemistry, 595 113618, 113618. doi: 10.1016/j.ab.2020.113618

Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor

Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899

Enabling the direct enzymatic dehydration of d-Glycerate to pyruvate as the key step in synthetic enzyme cascades used in the cell-free production of fine chemicals

Sutiono, Samuel, Teshima, Mariko, Beer, Barbara, Schenk, Gerhard and Sieber, Volker (2020). Enabling the direct enzymatic dehydration of d-Glycerate to pyruvate as the key step in synthetic enzyme cascades used in the cell-free production of fine chemicals. ACS Catalysis, 10 (5), 3110-3118. doi: 10.1021/acscatal.9b05068

Effect of chemically distinct substrates on the mechanism and reactivity of a highly promiscuous metallohydrolase

Sharma, Gaurav, Jayasinghe-Arachchige, Vindi M., Hu, Qiaoyu, Schenk, Gerhard and Prabhakar, Rajeev (2020). Effect of chemically distinct substrates on the mechanism and reactivity of a highly promiscuous metallohydrolase. ACS Catalysis, 10 (6), 3684-3696. doi: 10.1021/acscatal.9b04847

Polynuclear zinc(II) complexes of thiosemicarbazone: synthesis, X-ray structure and biological evaluation

Saswati, Mohanty, Monalisa, Banerjee, Atanu, Biswal, Sonaleen, Horn, Adolfo, Schenk, Gerhard, Brzezinski, Krzysztof, Sinn, Ekkehard, Reuter, Hans and Dinda, Rupam (2020). Polynuclear zinc(II) complexes of thiosemicarbazone: synthesis, X-ray structure and biological evaluation. Journal of Inorganic Biochemistry, 203 110908, 110908. doi: 10.1016/j.jinorgbio.2019.110908

Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops

Feder, Daniel, McGeary, Ross P., Mitić, Natasa, Lonhienne, Thierry, Furtado, Agnelo, Schulz, Benjamin L., Henry, Robert J., Schmidt, Susanne, Guddat, Luke W. and Schenk, Gerhard (2020). Structural elements that modulate the substrate specificity of plant purple acid phosphatases: avenues for improved phosphorus acquisition in crops. Plant Science, 294 110445, 110445. doi: 10.1016/j.plantsci.2020.110445

Engineering proton conductivity in melanin using metal doping

Mostert, A. Bernardus, Rienecker, Shermiyah B., Sheliakina, Margarita, Zierep, Paul, Hanson, Graeme R., Harmer, Jeffrey R., Schenk, Gerhard and Meredith, Paul (2020). Engineering proton conductivity in melanin using metal doping. Journal of Materials Chemistry B, 8 (35), 8050-8060. doi: 10.1039/d0tb01390k

Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective

Uribe, Elena, Reyes, María-Belen, Martínez, Ignacio, Mella, Kelly, Salas, Mónica, Tarifeño-Saldivia, Estefanía, López, Vasthi, García-Robles, María, Martínez-Oyanedel, José, Figueroa, Maximiliano, Carvajal, Nelson and Schenk, Gerhard (2020). Functional analysis of the Mn2+ requirement in the catalysis of ureohydrolases arginase and agmatinase - a historical perspective. Journal of Inorganic Biochemistry, 202 110812, 110812. doi: 10.1016/j.jinorgbio.2019.110812

Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents

Imran, Muhammad, Javed, Tariq, Jabeen, Asma, Mehnaz, Gul, Ullah, Kalim, Shaheen, Nusrat, Khalid, Sofia, Amirzada, Muhammad Imran, Yameen, Muhammad Arafat, Hasan, S. M. Farid, Shah, Sajid Hussain, Rauf, Khalid, Schenk, Gary, McGeary, Ross, Pieters, Luc, Latif, Muhammad, Al-Kahraman, Yasser Msa and Hassan Bin Asad, Muhammad Hassham (2020). Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents. Pakistan Journal of Pharmaceutical Sciences, 33 (1 Supplement), 385-392. doi: 10.36721/PJPS.2020.33.1.SUP.385-392.1

Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis

Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611

Editorial: Advances in the development of artificial metalloenzymes

Parac-Vogt, Tatjana N., Erxleben, Andrea, Schenk, Gerhard and Prabhakar, Rajeev (2019). Editorial: Advances in the development of artificial metalloenzymes. Frontiers in Chemistry, 7 599, 599. doi: 10.3389/fchem.2019.00599

Guanidine- and purine-functionalized ligands of FeIIIZnII complexes: effects on the hydrolysis of DNA

Pereira, Claudia, Farias, Giliandro, Maranha, Filipy G., Castilho, Nathalia, Schenk, Gerhard, de Souza, Bernardo, Terenzi, Hernán, Neves, Ademir and Peralta, Rosely A. (2019). Guanidine- and purine-functionalized ligands of FeIIIZnII complexes: effects on the hydrolysis of DNA. Journal of Biological Inorganic Chemistry, 24 (5), 675-691. doi: 10.1007/s00775-019-01680-3

The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state

Feder, Daniel, Gahan, Lawrence R., McGeary, Ross P., Guddat, Luke W. and Schenk, Gerhard (2019). The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state. ChemBioChem, 20 (12), 1536-1540. doi: 10.1002/cbic.201900077

Expansin assisted bio-affinity immobilization of endoxylanase from Bacillus subtilis onto corncob residue: characterization and efficient production of xylooligosaccharides

Wu, Bin, Yu, Qi, Chang, Siyuan, Pedroso, Marcelo Monteiro, Gao, Zhen, He, Bingfang and Schenk, Gerhard (2019). Expansin assisted bio-affinity immobilization of endoxylanase from Bacillus subtilis onto corncob residue: characterization and efficient production of xylooligosaccharides. Food Chemistry, 282, 101-108. doi: 10.1016/j.foodchem.2019.01.004

Proteomics reveals profound metabolic changes in the alcohol use disorder brain

Enculescu, Charmaine, Kerr, Edward D., Yeo, K. Y. Benjamin, Schenk, Gerhard, Fortes, Marina R. S. and Schulz, Benjamin L. (2019). Proteomics reveals profound metabolic changes in the alcohol use disorder brain. ACS Chemical Neuroscience, 10 (5), 2364-2373. doi: 10.1021/acschemneuro.8b00660

Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus

Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019). Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 (5) e00704, e00704. doi: 10.1002/mbo3.704

Investigating coordination flexibility of glycerophosphodiesterase (GpdQ) through interactions with mono-, di-, and triphosphoester (NPP, BNPP, GPE, and paraoxon) substrates

Sharma, Gaurav, Hu, Qiaoyu, Jayasinghe-Arachchige, Vindi M., Paul, Thomas J., Schenk, Gerhard and Prabhakar, Rajeev (2019). Investigating coordination flexibility of glycerophosphodiesterase (GpdQ) through interactions with mono-, di-, and triphosphoester (NPP, BNPP, GPE, and paraoxon) substrates. Physical Chemistry Chemical Physics, 21 (10), 5499-5509. doi: 10.1039/c8cp07031h

Synthesis and evaluation of novel purple acid phosphatase inhibitors

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019). Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 (1), 61-71. doi: 10.1039/c8md00491a

A new mixed-valence Mn(II)Mn(III) compound with catalase and superoxide dismutase activities

Costal, Rafael O., Ferreira, Sarah S., Pereira, Crystiane A., Harmer, Jeffrey R., Noble, Christopher J., Schenk, Gerhard, Franco, Roberto W. A., Resende, Jackson A. L. C., Comba, Peter, Roberts, Asha E., Fernandes, Christiane and Horn Jr, Adolfo (2018). A new mixed-valence Mn(II)Mn(III) compound with catalase and superoxide dismutase activities. Frontiers in Chemistry, 6 (NOV) 491, 491. doi: 10.3389/fchem.2018.00491

Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5

Synthesis, magnetic properties, and catalytic properties of a nickel(II)-dependent biomimetic of metallohydrolases

Horn, Adolfo, Englert, Daniel, Roberts, Asha E., Comba, Peter, Schenk, Gerhard, Krenske, Elizabeth H. and Gahan, Lawrence R. (2018). Synthesis, magnetic properties, and catalytic properties of a nickel(II)-dependent biomimetic of metallohydrolases. Frontiers in Chemistry, 6 441, 441. doi: 10.3389/fchem.2018.00441

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018). Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157, 462-479. doi: 10.1016/j.ejmech.2018.08.004

Formation of catalytically active binuclear center of glycerophosphodiesterase: a molecular dynamics study

Paul, Thomas J., Schenk, Gerhard and Prabhakar, Rajeev (2018). Formation of catalytically active binuclear center of glycerophosphodiesterase: a molecular dynamics study. The Journal of Physical Chemistry Part B, 122 (22), 5797-5808. doi: 10.1021/acs.jpcb.8b02046

Metabolic strategies for the degradation of the neuromodulator agmatine in mammals

Benítez, José, García, David, Romero, Nicol, González, Arlette, Martinez-Oyanedel, José, Figueroa, Maximiliano, Salas, Mónica, López, Vasthi, Garcia-Robles, Maria, Dodd, Peter R., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2018). Metabolic strategies for the degradation of the neuromodulator agmatine in mammals. Metabolism, 81, 35-44. doi: 10.1016/j.metabol.2017.11.005

The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure

Sidjabat, Hanna E., Gien, Jolene, Kvaskoff, David, Ashman, Keith, Vaswani, Kanchan, Reed, Sarah, McGeary, Ross P., Paterson, David L., Bordin, Amanda and Schenk, Gerhard (2018). The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure. Scientific Reports, 8 (1) 3871, 3871. doi: 10.1038/s41598-018-21984-9

Copper ions and coordination complexes as novel carbapenem adjuvants

Djoko, Karrera Y., Achard, Maud E. S., Phan, Minh-Duy, Lo, Alvin W., Miraula, Manfredi, Prombhul, Sasiprapa, Hancock, Steven J., Peters, Kate M., Sidjabat, Hanna E., Harris, Patrick N., Mitić, Nataša, Walsh, Timothy R., Anderson, Gregory J., Shafer, William M., Paterson, David L., Schenk, Gerhard, McEwan, Alastair G. and Schembri, Mark A. (2018). Copper ions and coordination complexes as novel carbapenem adjuvants. Antimicrobial Agents and Chemotherapy, 62 (2) e02280-17. doi: 10.1128/AAC.02280-17

Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates

Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018). Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 (1) 20, 1-15. doi: 10.1186/s13068-018-1022-2

Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity

Patel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017). Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry- A European Journal, 23 (72), 18289-18295. doi: 10.1002/chem.201704481

Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity Properties

Camargo, Tiago Pacheco, Neves, Ademir, Peralta, Rosely A., Chaves, Cláudia, Maia, Elene C. P., Lizarazo-Jaimes, Edgar H., Gomes, Dawidson A., Bortolotto, Tiago, Norberto, Douglas R., Terenzi, Hernán, Tierney, David L. and Schenk, Gerhard (2017). Second-Sphere Effects in Dinuclear FeIIIZnII Hydrolase Biomimetics: Tuning Binding and Reactivity Properties. Inorganic Chemistry, 57 (1), 187-203. doi: 10.1021/acs.inorgchem.7b02384

Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade

Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017). Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 (Pt A), 1084-1092. doi: 10.1016/j.biortech.2017.08.203

Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community

Pedroso, Marcelo Monteiro, Selleck, Christopher, Enculescu, Charmaine, Harmer, Jeffrey R., Mitic, Natasa, Craig, Whitney R., Helweh, Waleed, Hugenholtz, Philip, Tyson, Gene W., Tierney, David L., Larrabee, James A. and Schenk, Gerhard (2017). Characterization of a highly efficient antibiotic-degrading metallo-β-lactamase obtained from an uncultured member of a permafrost community. Metallomics, 9 (8), 1157-1168. doi: 10.1039/c7mt00195a

Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes

Pedroso, Marcelo M., Ely, Fernanda, Carpenter, Margaret C., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Wilcox, Dean E. and Schenk, Gerhard (2017). Mechanistic insight from calorimetric measurements of the assembly of the binuclear metal active site of glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Biochemistry, 56 (26), 3328-3336. doi: 10.1021/acs.biochem.6b01200

High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase

Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017). High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177, 287-290. doi: 10.1016/j.jinorgbio.2017.06.013

Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor

McGeary, Ross P., Tan, Daniel T. C., Selleck, Christopher, Monteiro Pedroso, Marcelo, Sidjabat, Hanna E. and Schenk, Gerhard (2017). Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-β-lactamase inhibitor. European Journal of Medicinal Chemistry, 137, 351-364. doi: 10.1016/j.ejmech.2017.05.061

Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents

Monteiro Pedroso, Marcelo, Selleck, Christopher, Bilyj, Jessica, Harmer, Jeffrey R. , Gahan, Lawrence R. , Mitić, Natasa, Standish, Alistair J. , Tierney, David L. , Larrabee, James A. and Schenk, Gerhard (2017). Reaction mechanism of the metallohydrolase CpsB from Streptococcus pneumoniae, a promising target for novel antimicrobial agents. Dalton Transactions, 46 (39), 13194-13201. doi: 10.1039/c7dt01350g

Progress toward inhibitors of metallo-β-lactamases

McGeary, Ross P., Tan, Daniel T. C. and Schenk, Gerhard (2017). Progress toward inhibitors of metallo-β-lactamases. Future Medicinal Chemistry, 9 (7), 673-691. doi: 10.4155/fmc-2017-0007

Is CuII coordinated to patellamides inside Prochloron cells?

Comba, Peter, Eisenschmidt, Annika, Gahan, Lawrence R., Herten, Dirk-Peter , Nette, Geoffrey, Schenk, Gerhard and Seefeld, Martin (2017). Is CuII coordinated to patellamides inside Prochloron cells?. Chemistry - A European Journal, 23 (50), 12264-12274. doi: 10.1002/chem.201700895

Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme

Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017). Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 (20), 4778-4781. doi: 10.1002/chem.201700866

Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies

Möhler, Jasper S., Kolmar, Theresa, Synnatschke, Kevin, Hergert, Marcel, Wilson, Liam A., Ramu, Soumya, Elliott, Alysha G., Blaskovich, Mark A.T., Sidjabat, Hanna E., Paterson, David L., Schenk, Gerhard, Cooper, Matthew A. and Ziora, Zyta M. (2017). Enhancement of antibiotic-activity through complexation with metal ions - Combined ITC, NMR, enzymatic and biological studies. Journal of Inorganic Biochemistry, 167, 134-141. doi: 10.1016/j.jinorgbio.2016.11.028

Insights into an evolutionary strategy leading to antibiotic resistance

Hou, Chun-Feng D., Liu, Jian-wei, Collyer, Charles, Mitić, Natasha, Pedroso, Marcelo Monteiro, Schenk, Gerhard and Ollis, David L. (2017). Insights into an evolutionary strategy leading to antibiotic resistance. Scientific Reports, 7 (1) 40357, 40357.1-40357.13. doi: 10.1038/srep40357

Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases

Romero, Nicol, Benitez, José, Garcia, David, Gonzalez, Arlette, Bennun, Leonardo, Garcia-Robles, María A., Lopez, Vasthi, Wilson, Liam A., Schenk, Gerhard, Carvajal, Nelson and Uribe, Elena (2017). Mammalian agmatinases constitute unusual members in the family of Mn2+-dependent ureahydrolases. Journal of Inorganic Biochemistry, 166, 122-125. doi: 10.1016/j.jinorgbio.2016.11.015

AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility

Selleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016). AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 (49), 17704-17714. doi: 10.1002/chem.201602762

Product release is rate-limiting for catalytic processing by the Dengue virus protease

Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G. and Young, P. R. (2016). Product release is rate-limiting for catalytic processing by the Dengue virus protease. Scientific Reports, 6 (1) 37539, 37539. doi: 10.1038/srep37539

New strategies to combat tuberculosis

Schenk, Gerhard and Guddat, Luke W. (2016). New strategies to combat tuberculosis. Australasian Biotechnology, 26 (3), 52-53.

Metallohydrolase biomimetics with catalytic and structural flexibility

Mendes, Luisa L., Englert, Daniel, Fernandes, Christiane, Gahan, Lawrence R., Schenk, Gerhard and Horn, Adolfo Jr. (2016). Metallohydrolase biomimetics with catalytic and structural flexibility. Dalton Transactions, 45 (46), 18510-18521. doi: 10.1039/c6dt03200a

Preface

Gahan, Lawrence, Comba, Peter, Schenk, Gerhard, Daumann, Lena, Hambley, Trevor and Berners-Price, Sue (2016). Preface. Journal of Inorganic Biochemistry, 162, 162-163. doi: 10.1016/j.jinorgbio.2016.09.011

Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks

Miraula, Manfredi, Schenk, Gerhard and Mitic, Natasa (2016). Promiscuous metallo-β-lactamases: MIM-1 and MIM-2 may play an essential role in quorum sensing networks. Journal of Inorganic Biochemistry, 162, 366-375. doi: 10.1016/j.jinorgbio.2015.12.014

Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediation

Schenk, Gerhard, Mateen, Irsa, Ng, Tee-Kheang, Pedroso, Marcelo M., Mitic, Natasa, Jafelicci, Miguel, Marques, Rodrigo F. C., Gahan, Lawrence R. and Ollis, David L. (2016). Organophosphate-degrading metallohydrolases: structure and function of potent catalysts for applications in bioremediation. Coordination Chemistry Reviews, 317, 122-131. doi: 10.1016/j.ccr.2016.03.006

Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase

Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016). Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 (22), 7427-7436. doi: 10.1002/chem.201600620

Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1

Arjomandi, Omid Khalili, Hussein, Waleed M., Vella, Peter, Yusof, Yusralina, Sidjabat, Hanna E., Schenk, Gerhard and McGeary, Ross P. (2016). Design, synthesis, and in vitro and biological evaluation of potent amino acid-derived thiol inhibitors of the metallo-β-lactamase IMP-1. European Journal of Medicinal Chemistry, 114, 318-327. doi: 10.1016/j.ejmech.2016.03.017

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery

You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016). Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 (7), 1184-1196. doi: 10.1111/febs.13672

Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases

Brown, Joshua J., Gahan, Lawrence R., Schöffler, Anne, Krenske, Elizabeth H. and Schenk, Gerhard (2016). Investigation of the identity of the nucleophile initiating the hydrolysis of phosphate esters catalyzed by dinuclear mimics of metallohydrolases. Journal of Inorganic Biochemistry, 162, 356-365. doi: 10.1016/j.jinorgbio.2016.02.008

Captopril analogues as metallo-β-lactamase inhibitors

Yusof, Yusralina, Tan, Daniel T. C., Arjomandi, Omid Khalili, Schenk, Gerhard and McGeary, Ross P. (2016). Captopril analogues as metallo-β-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (6), 1589-1593. doi: 10.1016/j.bmcl.2016.02.007

Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases

Bosch, Simone, Comba, Peter, Gahan, Lawrence R. and Schenk, Gerhard (2016). Asymmetric mono- and dinuclear GaIII and ZnII complexes as models for purple acid phosphatases. Journal of Inorganic Biochemistry, 162, 343-355. doi: 10.1016/j.jinorgbio.2015.12.028

CaII binding regulates and dominates the reactivity of a transition-metal-ion-dependent diesterase from Mycobacterium tuberculosis

Pedroso, Marcelo M., Larrabee, James A., Ely, Fernanda, Gwee, Shuhui E., Mitic, Natasa, Ollis, David L., Gahan, Lawrence R. and Schenk, Gerhard (2016). CaII binding regulates and dominates the reactivity of a transition-metal-ion-dependent diesterase from Mycobacterium tuberculosis. Chemistry - A European Journal, 22 (3), 999-1009. doi: 10.1002/chem.201504001

Induction of apoptosis in leukemia cell lines by new copper(II) complexes containing naphthyl groups via interaction with death receptors

Fernandes, Christiane, Horn Jr, Adolfo, Lopes, Bruna F., Bull, Erika S., Azeredo, Nathália F., Kanashiro, Milton M., Borges, Franz V., Bortoluzzi, Adailton J., Szpoganicz, Bruno, Pires, Anderson B., Franco, Roberto W. A., de A. Almeida, João Carlos, Maciel, Leide L. F., Resende, Jackson A. L. C. and Schenk, Gerhard (2015). Induction of apoptosis in leukemia cell lines by new copper(II) complexes containing naphthyl groups via interaction with death receptors. Journal of Inorganic Biochemistry, 153, 68-87. doi: 10.1016/j.jinorgbio.2015.09.014

Heavy Water as a Probe of the Free Radical Nature and Electrical Conductivity of Melanin

Rienecker, Shermiyah B., Mostert, A. Bernardus, Schenk, Gerhard, Hanson, Graeme R. and Meredith, Paul (2015). Heavy Water as a Probe of the Free Radical Nature and Electrical Conductivity of Melanin. Journal of Physical Chemistry B, 119 (48), 14994-15000. doi: 10.1021/acs.jpcb.5b08970

Selective coordination of gallium(III), zinc(II), and copper(II) by an asymmetric dinucleating ligand: a model for metallophosphatases

Bosch, Simone, Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Noble, Christopher, Schenk, Gerhard and Wadepohl, Hubert (2015). Selective coordination of gallium(III), zinc(II), and copper(II) by an asymmetric dinucleating ligand: a model for metallophosphatases. Chemistry - A European Journal, 21 (50), 18269-18279. doi: 10.1002/chem.201503348

Use of magnetic circular dichroism to study dinuclear metallohydrolases and the corresponding biomimetics

Larrabee, James A., Schenk, Gerhard, Mitic, Natasa and Riley, Mark J. (2015). Use of magnetic circular dichroism to study dinuclear metallohydrolases and the corresponding biomimetics. European Biophysics Journal, 44 (6), 393-415. doi: 10.1007/s00249-015-1053-6

An approach to more accurate model systems for purple acid phosphatases (PAPs)

Bernhardt, Paul V., Bosch, Simone, Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Schenk, Gerhard and Wadepohl, Hubert (2015). An approach to more accurate model systems for purple acid phosphatases (PAPs). Inorganic Chemistry, 54 (15), 7249-7263. doi: 10.1021/acs.inorgchem.5b00628

A Heterodinuclear Fe^IIIZn^II Complex as a Mimic for Purple Acid Phosphatase with Site-Specific Zn^II Binding

Roberts, Asha E, Schenk, Gerhard and Gahan, Lawrence R (2015). A Heterodinuclear FeIIIZnII Complex as a Mimic for Purple Acid Phosphatase with Site-Specific ZnII Binding. European Journal of Inorganic Chemistry, 2015 (19), 3076-3086. doi: 10.1002/ejic.201500351

Altering the substrate specificity of methyl parathion hydrolase with directed evolution

Ng, Tee-Kheang, Gahan, Lawrence R., Schenk, Gerhard and Ollis, David L. (2015). Altering the substrate specificity of methyl parathion hydrolase with directed evolution. Archives of Biochemistry and Biophysics, 573, 59-68. doi: 10.1016/j.abb.2015.03.012.

Insight on the interaction of an agmatinase-like protein with Mn(2 +) activator ions

Quiñones, Matías, Cofre, Jaime, Benítez, José, García, David, Romero, Nicol, González, Arlette, Carvajal, Nelson, García, María, López, Vasthi, Schenk, Gerhard and Uribe, Elena (2015). Insight on the interaction of an agmatinase-like protein with Mn(2 +) activator ions. Journal of Inorganic Biochemistry, 145, 65-69. doi: 10.1016/j.jinorgbio.2015.01.008

Inteins—A focus on the biotechnological applications of splicing-promoting proteins

Miraula, Manfredi, Enculescu, Charmaine, Schenk, Gerhard and Mitić, Nataša (2015). Inteins—A focus on the biotechnological applications of splicing-promoting proteins. American Journal of Molecular Biology, 05 (02), 42-56. doi: 10.4236/ajmb.2015.52005

β-Lactam antibiotic-degrading enzymes from non-pathogenic marine organisms: a potential threat to human health

Miraula, Manfredi, Whitaker, Jacob J, Schenk, Gerhard and Mitic, Natasa (2015). β-Lactam antibiotic-degrading enzymes from non-pathogenic marine organisms: a potential threat to human health. Journal of Biological Inorganic Chemistry, 20 (4), 639-651. doi: 10.1007/s00775-015-1250-x

Iron, copper and manganese complexes with in vitro superoxide dismutase and/or catalase activities that keep Saccharomyces cerevisiae cells alive under severe oxidative stress

Ribeiro, Thales P., Fernandes, Christiane, Melo, Karen V., Ferreira, Sarah S., Lessa, Josane A., Franco, Roberto W A., Schenk, Gerhard, Pereira, Marcos D. and Horn, Adolfo (2015). Iron, copper and manganese complexes with in vitro superoxide dismutase and/or catalase activities that keep Saccharomyces cerevisiae cells alive under severe oxidative stress. Free Radical Biology and Medicine, 80, 67-76. doi: 10.1016/j.freeradbiomed.2014.12.005

A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, providing insight into the activation mechanism

Guilfoyle, Amy P., Deshpande, Chandrika N., Font Sadurni, Josep, Ash, Miriam-Rose, Tourle, Samuel, Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). A GTPase chimera illustrates an uncoupled nucleotide affinity and release rate, providing insight into the activation mechanism. Biophysical Journal, 107 (12), L45-L48. doi: 10.1016/j.bpj.2014.10.064

Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release

Guilfoyle, Amy P., Deshpande, Chandrika N., Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release. Bioscience Reports, 34 (6) e00158, 789-796. doi: 10.1042/BSR20140152

X-ray absorption spectroscopy of dinuclear metallohydrolases

Tierney, David L. and Schenk, Gerhard (2014). X-ray absorption spectroscopy of dinuclear metallohydrolases. Biophysical Journal, 107 (6), 1263-1272. doi: 10.1016/j.bpj.2014.07.066

Dinuclear zinc(II) complexes with hydrogen bond donors as structural and functional phosphatase models

Bosch, Simone, Comba, Peter, Gahan, Lawrence R. and Schenk, Gerhard (2014). Dinuclear zinc(II) complexes with hydrogen bond donors as structural and functional phosphatase models. Inorganic Chemistry, 53 (17), 9036-9051. doi: 10.1021/ic5009945

Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH).

Pedroso, Marcelo M., Ely, Fernanda, Mitic, Natasa, Carpenter, Margaret C., Gahan, Lawrence R., Wilcox, Dean E., Larrabee, James L., Ollis, David L. and Schenk, Gerhard (2014). Comparative investigation of the reaction mechanisms of the organophosphate-degrading phosphotriesterases from Agrobacterium radiobacter (OpdA) and Pseudomonas diminuta (OPH).. Journal of Biological Inorganic Chemistry, 19 (8), 1263-1275. doi: 10.1007/s00775-014-1183-9

Metallo-β-lactamases: a major threat to human health

Phelan, Emer K., Miraula, Manfred, Selleck, Christopher, Ollis, David L., Schenk, Gerhard and Mitic, Natasa (2014). Metallo-β-lactamases: a major threat to human health. American Journal of Molecular Biology, 4 (3), 89-104. doi: 10.4236/ajmb.2014.43011

Metallo-beta-lactamases and their biomimetic complexes

Daumann, Lena J., Schenk, Gerhard and Gahan, Lawrence R. (2014). Metallo-beta-lactamases and their biomimetic complexes. European Journal of Inorganic Chemistry, 2014 (18), 2869-2885. doi: 10.1002/ejic.201402203

Synthesis, characterization, antibacterial and antitumoral activities of mononuclear zinc complexes containing tridentate amine based ligands with N3 or N2O donor groups

Fernandes, Christiane, Horn, Adolfo, Vieira-Da-Motta, Olney, Kanashiro, Milton M., Rocha, Michelle R., Moreira, Rafaela O., Morcelli, Samila R., Lopes, Bruna F., Mathias, Luciana da S., Borges, Franz V., Borges, Layla J. H., Freitas, William R., Visentin, Lorenzo C., Almeida, Joao C. de A. and Schenk, Gerhard (2014). Synthesis, characterization, antibacterial and antitumoral activities of mononuclear zinc complexes containing tridentate amine based ligands with N3 or N2O donor groups. Inorganica Chimica Acta, 416, 35-48. doi: 10.1016/j.ica.2014.02.040

Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate

Guilfoyle, Amy P., Deshpande, Chandrika N., Vincent, Kimberley, Pedroso, Marcelo M., Schenk, Gerhard, Maher, Megan J. and Jormakka, Mika (2014). Structural and functional analysis of a FeoB A143S G5 loop mutant explains the accelerated GDP release rate. FEBS Journal, 281 (9), 2254-2265. doi: 10.1111/febs.12779

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases

McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014). The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76, 132-144. doi: 10.1016/j.ejmech.2014.02.008

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry

Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014). Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 (3), 389-398. doi: 10.1007/s00775-013-1079-0

Unusual metallo-beta-lactamases may constitute a new subgroup in this family of enzymes

Hou, Chun-Feng D., Phelan, Emer K., Miraula, Manfredi, Ollis, David L., Schenk, Gerhard and Mitić, Nataša (2014). Unusual metallo-beta-lactamases may constitute a new subgroup in this family of enzymes. American Journal of Molecular Biology, 4 (1), 11-15. doi: 10.4236/ajmb.2014.41002

Immobilization of the enzyme GpdQ on magnetite nanoparticles for organophosphate pesticide bioremediation

Daumann, Lena J., Larrabee, James A., Ollis, David, Schenk, Gerhard and Gahan, Lawrence R. (2014). Immobilization of the enzyme GpdQ on magnetite nanoparticles for organophosphate pesticide bioremediation. Journal of Inorganic Biochemistry, 131, 1-7. doi: 10.1016/j.jinorgbio.2013.10.007

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Daumann, Lena J., Schenk, Gerhard, Ollis, David L. and Gahan, Lawrence R. (2014). Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes. Dalton Transactions, 43 (3), 910-928. doi: 10.1039/c3dt52287c

Highly efficient synthetic iron-dependent nucleases activate both intrinsic and extrinsic apoptotic death pathways in leukemia cancer cells

Horn, Adolfo, Jr., Fernandes, Christiane, Parrilha, Gabrieli L., Kanashiro, Milton M., Borges, Franz V., de Melo, Edesio J. T., Schenk, Gerhard, Terenzi, Hernan and Pich, Claus T. (2013). Highly efficient synthetic iron-dependent nucleases activate both intrinsic and extrinsic apoptotic death pathways in leukemia cancer cells. Journal of Inorganic Biochemistry, 128, 38-47. doi: 10.1016/j.jinorgbio.2013.07.019

Identification and preliminary characterization of novel B3-type metallo-beta-lactamases

Miraula, Manfredi, Brunton, Conor S., Schenk, Gerhard and Mitić, Nataša (2013). Identification and preliminary characterization of novel B3-type metallo-beta-lactamases. American Journal of Molecular Biology, 3 (4), 198-203. doi: 10.4236/ajmb.2013.34026

Identification and characterization of an unusual metallo-beta-lactamase from Serratia proteamaculans

Vella, Peter, Miraula, Manfredi, Phelan, Emer, Leung, Eleanor W. W., Ely, Fernanda, Ollis, David L., McGeary, Ross P., Schenk, Gerhard and Mitić, Nataša (2013). Identification and characterization of an unusual metallo-beta-lactamase from Serratia proteamaculans. Journal of Biological Inorganic Chemistry, 18 (7), 855-863. doi: 10.1007/s00775-013-1035-z

Asymmetric zinc(II) complexes as functional and structural models for phosphoesterases

Daumann, Lena J., Marty, Laurene, Schenk, Gerhard and Gahan, Lawrence R. (2013). Asymmetric zinc(II) complexes as functional and structural models for phosphoesterases. Dalton Transactions, 42 (26), 9574-9584. doi: 10.1039/c3dt50514f

Dinuclear cobalt(II) omplexes as metallo--lactamase mimics

Daumann, Lena J., Larrabee, James A., Comba, Peter, Schenk, Gerhard and Gahan, Lawrence R. (2013). Dinuclear cobalt(II) omplexes as metallo--lactamase mimics. European Journal of Inorganic Chemistry, 2013 (17), 3082-3089. doi: 10.1002/ejic.201300280

Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics

Dalle, Kristian E., Daumann, Lena J., Schenk, Gerhard, McGeary, Ross P., Hanton, Lyall R. and Gahan, Lawrence R. (2013). Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics. Polyhedron, 52, 1336-1343. doi: 10.1016/j.poly.2012.06.008

Synthesis, magnetic properties, and phosphoesterase activity of dinuclear cobalt(II) complexes

Daumann, Lena J., Comba, Peter, Larrabee, James A., Schenk, Gerhard, Stranger, Robert, Cavigiasso, German and Gahan, Lawrence R. (2013). Synthesis, magnetic properties, and phosphoesterase activity of dinuclear cobalt(II) complexes. Inorganic Chemistry, 52 (4), 2029-2043. doi: 10.1021/ic302418x

Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme

Schenk, Gerhard, Mitić, Nataša, Hanson, Graeme R. and Comba, Peter (2013). Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme. Coordination Chemistry Reviews, 257 (2), 473-482. doi: 10.1016/j.ccr.2012.03.020

Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ

Daumann, Lena J., McCarthy, Bianca Y., Hadler, Kieran S., Murray, Tracy P., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2013). Promiscuity comes at a price: catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ. Biochimica Et Biophysica Acta-Proteins and Proteomics, 1834 (1), 425-432. doi: 10.1016/j.bbapap.2012.02.004

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012). Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 (5), 665-674. doi: 10.1111/cbdd.12001

Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model system

Comba, Peter, Gahan, Lawrence R., Mereacre, Valeriu, Hanson, Graeme R., Powell, Annie K., Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model system. Inorganic Chemistry, 51 (22), 12195-12209. doi: 10.1021/ic301347t

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle

Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012). Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 (3-4), 168-179. doi: 10.1016/j.jmb.2012.09.018

Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Hussein, Waleed M., Fatahala, Samar S., Mohamed, Zainab M., McGeary, Ross P., Schenk, Gerhard, Ollis, David L. and Mohamed, Mosaad S. (2012). Synthesis and kinetic testing of tetrahydropyrimidine-2-thione and pyrrole derivatives as inhibitors of the metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology and Drug Design, 80 (4), 500-515. doi: 10.1111/j.1747-0285.2012.01440.x

Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction

Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012). Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 (9), 1593-1603. doi: 10.1021/ar300067g

Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamases

Daumann, Lena J., Gahan, Lawrence R., Comba, Peter and Schenk, Gerhard (2012). Cadmium(II) complexes: Mimics of organophosphate pesticide degrading enzymes and metallo-β-lactamases. Inorganic Chemistry, 51 (14), 7669-7681. doi: 10.1021/ic300687y

Penicillin inhibitors of purple acid phosphatase

Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012). Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 (7), 2555-2559. doi: 10.1016/j.bmcl.2012.01.123

Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform

Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Prisecaru, Ion, Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012). Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform. Chemistry: A European Journal, 18 (6), 1700-1710. doi: 10.1002/chem.201100229

Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage

Smith, Sarah J., Peralta, Rosely A., Jovito, Rafael, Horn, Adolfo, Bortoluzzi, Adailton J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Gahan, Lawrence R., Schenk, Gerhard, Nascimento, Otaciro R., Cavalett, Angelica, Bortolotto, Tiago, Razzera, Guilherme, Terenzi, Hernan, Neves, Ademir and Riley, Mark J. (2012). Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage. Inorganic Chemistry, 51 (4), 2065-2078. doi: 10.1021/ic201711p

3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors

Faridoon, Hussein, Waleed M., Vella, Peter, Ul Islam, Nazar, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2012). 3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-beta-lactamase inhibitors. Bioorganic and Medicinal Chemistry Letters, 22 (1), 380-386. doi: 10.1016/j.bmcl.2011.10.116

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter

Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012). Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 (1), 19-22. doi: 10.1016/j.jinorgbio.2011.09.015

The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics

Daumann, Lena J., Dalle, Kristian E., Schenk, Gerhard, McGeary, Ross P., Bernhardt, Paul V., Ollis, David L. and Gahan, Lawrence R. (2012). The role of Zn-OR and Zn-OH nucleophiles and the influence of para-substituents in the reactions of binuclear phosphatase mimetics. Dalton Transactions, 41 (6), 1695-1708. doi: 10.1039/c1dt11187f

Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme

Yip, Sylvia H-C., Foo, Jee-Loon, Schenk, Gerhard, Gahan, Lawrence R., Carr, Paul D. and Ollis, David L. (2011). Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme. Protein Engineering Design and Selection, 24 (12), 861-872. doi: 10.1093/protein/gzr048

Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

Mohamed, Mosaad S., Hussein, Waleed M., McGeary, Ross P., Vella, Peter, Schenk, Gerhard and Abd El-hameed, Rania H. (2011). Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry, 46 (12), 6075-6082. doi: 10.1016/j.ejmech.2011.10.030

Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA)

Ely, Fernanda, Hadler, Kieran S., Mitic, Natasa, Gahan, Lawrence R., Ollis, David L., Plugis, Nicholas M., Russo, Marie T., Larrabee, James A. and Schenk, Gerhard (2011). Electronic and geometric structures of the organophosphate-degrading enzyme from Agrobacterium radiobacter (OpdA). Journal of Biological Inorganic Chemistry, 16 (5), 777-787. doi: 10.1007/s00775-011-0779-6

The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening

Vella, Peter, Hussein, Waleed M., Leung, Eleanor W. W., Clayton, Daniel, Ollis, David L., Schenk, Gerhard and McGeary, Ross P. (2011). The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic and Medicinal Chemistry Letters, 21 (11), 3282-3285. doi: 10.1016/j.bmcl.2011.04.027

Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase

Mohd-Pahmi, Siti Hajar, Hussein, Waleed M., Schenk, Gerhard and McGeary, Ross P. (2011). Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 21 (10), 3092-3094. doi: 10.1016/j.bmcl.2011.03.024

A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies

Zee, Yoke Leng Michelle, Gahan, Lawrence R. and Schenk, Gerhard (2011). A potentially polymerizable heterodinuclear FeIIIZnII purple acid phosphatase mimic. Synthesis, characterization, and phosphate ester hydrolysis studies. Australian Journal of Chemistry, 64 (3), 258-264. doi: 10.1071/CH10424

Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.

Ugwumba, Isaac N., Ozawa, Kiyoshi, de la Cruz, Laura, Xu, Zhi-Qiang, Herlt, Anthony J., Hadler, Kieran S., Coppin, Chris, Brown, Susan E., Schenk, Gerhard, Oakeshott, John G. and Otting, Gottfried (2011). Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular weight compounds.. ASSAY and Drug Development Technologies, 9 (1), 50-57. doi: 10.1089/adt.2010.0306

Improving a natural enzyme activity through incorporation of unnatural amino acids

Ugwumba, Isaac N., Ozawa, Kiyoshi, Xu, Zhi-Qiang, Ely, Fernanda, Foo, Jee-Loon, Herlt, Anthony J., Coppin, Chris, Brown, Sue, Taylor, Matthew C., Ollis, David L., Mander, Lewis N., Schenk, Gerhard, Dixon, Nicholas E., Otting, Gottfried, Oakeshott, John G. and Jackson, Colin J. (2011). Improving a natural enzyme activity through incorporation of unnatural amino acids. Journal of The American Chemical Society, 133 (2), 326-333. doi: 10.1021/ja106416g

Phosphate ester cleavage promoted by a tetrameric iron(III) complex

Kantacha, A, Buchholz, R, Smith, SJ, Schenk, G and Gahan, LR (2011). Phosphate ester cleavage promoted by a tetrameric iron(III) complex. Journal of Biological Inorganic Chemistry, 16 (1), 25-32. doi: 10.1007/s00775-010-0696-0

Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activity

Peralta, RA, Bortoluzzi, AJ, de Souza, B, Jovito, R, Xavier, FR, Couto, RAA, Casellato, A, Nome, F, Dick, A, Gahan, LR, Schenk, G, Hanson, GR, de Paula, FCS, Pereira-Maia, EC, Machado, SD, Severino, PC, Pich, C, Bortolotto, T, Terenzi, H, Castellano, EE, Neves, A and Riley, MJ (2010). Electronic structure and spectro-structural correlations of FeIIIZnII biomimetics for purple acid phosphatases: Relevance to DNA cleavage and cytotoxic activity. Inorganic Chemistry, 49 (24), 11421-11438. doi: 10.1021/ic101433t

Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeutics

Vella, Peter, McGeary, Ross P., Gahan, Lawrence R. and Schenk, Gerhard (2010). Tartrate-resistant acid phosphatase: A target for anti-osteoporotic chemotherapeutics. Current Enzyme Inhibition, 6 (3), 118-129. doi: 10.2174/157340810793384133

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis

Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010). The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 (3), 565-573. doi: 10.1042/BJ20101054

Paradigm shift for the purple acid phosphatase reaction mechanism

Schenk, Gerhard (2010). Paradigm shift for the purple acid phosphatase reaction mechanism. Chemistry Australia, 77 (7), 9-9.

Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme

Foo, Jee‑Loon, Jackson, Colin J., Carr, Paul D., Kim, Hye‑Kyung, Schenk, Gerhard, Gahan, Lawrence R. and Ollis, David L. (2010). Mutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzyme. Biochemical Journal, 429 (2), 313-321. doi: 10.1042/BJ20100233

The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis

Mitic, Natasa, Hadler, Kieran S., Gahan, Lawrence R., Hengge, Alvan C. and Schenk, Gerhard (2010). The divalent metal ion in the active site of uteroferrin modulates substrate binding and catalysis. Journal of the American Chemical Society, 132 (20), 7049-7054. doi: 10.1021/ja910583y

Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes

Hadler, Kieran S., Mitic, Natasa, Yip, Sylvia Hsu-Chen, Gahan, Lawrence R., Ollis, David L., Schenk, Gerhard and Larrabee, James A. (2010). Electronic structure analysis of the dinuclear metal center in the bioremediator glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. Inorganic Chemistry, 49 (6), 2727-2734. doi: 10.1021/ic901950c

Catalytic promiscuity: Catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence Fe(III)Fe(II) complex

Neves, Ademir, Bortoluzzi, Adailton J., Jovito, Rafael, Peralta, Rosely A., de Souza, Bernardo, Szpoganicz, Bruno, Joussef, Antônio C., Terenzi, Hernán, Severino, Patricia C., Fischer, Franciele L., Schenk, Gerhard, Riley, Mark J., Smith, Sarah J. and Gahan, Lawrence R. (2010). Catalytic promiscuity: Catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence Fe(III)Fe(II) complex. Journal of the Brazilian Chemical Society, 21 (7), 1201-1212. doi: 10.1590/S0103-50532010000700007

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

Jackson, C. J., Foo, J.-L., Tokuriki, N., Afriat, L., Carr, P. D., Kim, H.-K., Schenk, G., Tawfik, D. S. and Ollis, D. L. (2009). Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase. Proceedings of the National Academy of Sciences, 106 (51), 21631-21636. doi: 10.1073/pnas.0907548106

Flexible and promiscuous!

Schenk, G., Ollis, D. L., Hanson, G. R. and Gahan, L. R. (2009). Flexible and promiscuous!. Chemistry in Australia, 76 (10), 10-11.

The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis

Hadler, Kieran S., Gahan, Lawrence R., Ollis, David L. and Schenk, Gerhard (2009). The bioremediator glycerophosphodiesterase employs a non-processive mechanism for hydrolysis. Journal of Inorganic Biochemistry, 104 (2), 211-213. doi: 10.1016/j.jinorgbio.2009.10.012

Structural and catalytic characterization of a heterovalent Mn(II)Mn(III) complex that mimics purple acid phosphatases

Sarah Sarah J., Riley, Mark J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Schenk, Gerhard and Gahan, Lawrence R. (2009). Structural and catalytic characterization of a heterovalent Mn(II)Mn(III) complex that mimics purple acid phosphatases. Inorganic Chemistry, 48 (21), 10036-10048. doi: 10.1021/ic9005086

Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis

Hadler, Kieran S., Mitic, Natasa, Ely, Fernanda, Hanson, Graeme R., Gahan, Lawrence R., Larrabee, James A., Ollis, David L. and Schenk, Gerhard (2009). Structural flexibility enhances the reactivity of the bioremediator glycerophosphodiesterase by fine-tuning its mechanism of hydrolysis. Journal of the American Chemical Society, 131 (33), 11900-11908. doi: 10.1021/ja903534f

Unsymmetrical FeIIICoIII and GaIIICoII complexes as chemical hydrolases: Biomimetic models for purple acid phosphatases (PAPs)

Xavier, Fernando R., Neves, Ademir, Casellato, Annelise, Peralta, Rosely A., Bortoluzzi, Adailton J., Szpoganicz, Bruno, Severino, Patricia C., Terenzi, Hernan, Tomkowicz, Zbigniew, Ostrovsky, Sergei, Haase, Wolfgang, Ozarowski, Andrew, Krzystek, Jerzy, Telser, Joshua, Schenk, Gerhard and Gahan, Lawrence R. (2009). Unsymmetrical FeIIICoIII and GaIIICoII complexes as chemical hydrolases: Biomimetic models for purple acid phosphatases (PAPs). Inorganic Chemistry, 48 (16), 7905-7921. doi: 10.1021/ic900831q

Metal-ion mutagenesis: Conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site

Mitić, Nataša, Noble, Christopher J., Gahan, Lawrence R., Hanson, Graeme R. and Schenk, Gerhard (2009). Metal-ion mutagenesis: Conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site. Journal of the American Chemical Society, 131 (23), 8173-8179. doi: 10.1021/ja900797u

Phosphate ester hydrolysis: Metal complexes as purple acid phosphatase and phosphotriesterase analogues

Gahan, Lawrence R., Smith, Sarah J., Neves, Ademir and Schenk, Gerhard (2009). Phosphate ester hydrolysis: Metal complexes as purple acid phosphatase and phosphotriesterase analogues. European Journal of Inorganic Chemistry, 2009 (19), 2745-2758. doi: 10.1002/ejic.200900231

Catalase vs peroxidase activity of a manganese(II) compound: Identification of a Mn(III)-(mu-O)(2)-Mn(IV) reaction intermediate by electrospray ionization mass spectrometry and electron paramagnetic resonance spectroscopy

Lessa, Josane A., Horn, Adolfo Jr., Bull, Érika S., Rocha, Michelle R., Benassi, Mario, Catharino, Rodrigo R., Eberlin, Marcos N., Casellato, Annelise, Noble, Christopher J., Hanson, Graeme R., Schenk, Gerhard, Silva, Giselle C., Antunes, O. A. C. and Fernandes, Christiane (2009). Catalase vs peroxidase activity of a manganese(II) compound: Identification of a Mn(III)-(mu-O)(2)-Mn(IV) reaction intermediate by electrospray ionization mass spectrometry and electron paramagnetic resonance spectroscopy. Inorganic Chemistry, 48 (10), 4569-4579. doi: 10.1021/ic801969c

GpdQ: a clever enzymatic bioremediator

Schenk, Gerhard (2009). GpdQ: a clever enzymatic bioremediator. Chemistry in Australia, 76 (1), 32-33.

Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids

McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009). Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 (1), 163-166. doi: 10.1016/j.bmcl.2008.10.125

Metal ion mutagenesis - how the replacement of metal ions can alter the properties of a metalloenzyme

Hanson, G. R., Gahan, L. R. and Schenk, G. (2009). Metal ion mutagenesis - how the replacement of metal ions can alter the properties of a metalloenzyme. Chemistry in Australia, 76 (8), 8-8.

Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes

Hadler, K., Tanifum, E.A., Yip, S.H.-C., Mitic, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A. and Schenk, G. (2008). Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 (43), 14129-14138. doi: 10.1021/ja803346w

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?

Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008). Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 (1) 78, 1-8. doi: 10.1186/1756-0500-1-78

Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference

Jackson, Colin J., Hadler, Kieran S., Carr, Paul D., Oakley, Aaron J., Yip, Sylvia, Schenk, Gerhard and Ollis, David L. (2008). Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, 64 (8), 681-685. doi: 10.1107/S1744309108017600

Cadmium(II) complexes of the glycerophosphodiester-degrading enzyme GpdQ and a biomimetic N,O ligand

Mirams, Ruth E., Smith, Sarah J., Hadler, Kieran S., Ollis, David L., Schenk, Gerhard and Gahan, Lawrence R. (2008). Cadmium(II) complexes of the glycerophosphodiester-degrading enzyme GpdQ and a biomimetic N,O ligand. Journal of Biological Inorganic Chemistry, 13 (7), 1065-1072. doi: 10.1007/s00775-008-0392-5

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008). Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6) 6, 1-13. doi: 10.1186/1472-6807-8-6

Structural and spectroscopic studies of a model for catechol oxidase

Smith, Sarah J., Noble, Christopher J., Palmer, Randahl C., Hanson, Graeme R., Schenk, Gerhard, Gahan, Lawrence R. and Riley, Mark J. (2008). Structural and spectroscopic studies of a model for catechol oxidase. Journal of Biological Inorganic Chemistry, 13 (4), 499-510. doi: 10.1007/s00775-007-0334-7

A structural and catalytic model for zinc phosphoesterases

Buchholz, Rebecca R., Etienne, Morgan E., Dorgelo, Anneke, Mirams, Ruth E., Smith, Sarah J., Chow, Shiao Yun, Hanton, Lyall R., Jameson, Geoffrey B., Schenk, Gerhard and Gahan, Lawrence R. (2008). A structural and catalytic model for zinc phosphoesterases. Dalton Transactions, 2008 (43), 6045-6054. doi: 10.1039/b806391e

Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases

Ely, F., Foo, J. L., Jackson, C. J., Gahan, L. R., Ollis, D. L. and Schenk, G. (2008). Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases. Current Topics in Biochemical Research, 2008 (9), 63-78.

Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics

Schenk, Gerhard, Peralta, Rosely A., Batista, Suzana Cimara, Bortoluzzi, Adailton J., Szpoganicz, Bruno, Dick, Andrew K., Herrald, Paul, Hanson, Graeme R., Szilagyi, Robert K., Riley, Mark J., Gahan, Lawrence R. and Neves, Ademir (2008). Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics. Journal of Biological Inorganic Chemistry, 13 (1), 139-155. doi: 10.1007/s00775-007-0305-z

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases

Boudalis, Athanassios K., Aston, Robyn E., Smith, Sarah J., Mirams, Ruth E., Riley, Mark J., Schenk, Gerhard, Blackman, Allan G., Hanton, Lyall R. and Gahan, Lawrence R. (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases. Dalton Transactions, 2007 (44), 5132-5139. doi: 10.1039/b709293h

The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics

Smith, S. J., Casellato, A., Hadler, K. S., Mitic, N., Riley, M. J., Bortoluzzi, A. J., Szpoganicz, B., Schenk, G., Neves, A. and Gahan, L. R. (2007). The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics. Journal of Biological Inorganic Chemistry, 12 (8), 1207-1220. doi: 10.1007/s00775-007-0286-y

Diesterase activity and substrate binding in purple acid phosphatases

Cox, R. S., Schenk, G., Mitic, N., Gahan, L. R. and Hengge, A. C. (2007). Diesterase activity and substrate binding in purple acid phosphatases. Journal of The American Chemical Society, 129 (31), 9550-9551. doi: 10.1021/ja072647q

Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability

Liu, J. W., Hadler, K. S., Schenk, G. and Ollis, D. (2007). Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability. FEBS Journal, 274 (18), 4742-4751. doi: 10.1111/j.1742-4658.2007.06022.x

Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme

Neidig, M., Wecksler, A., Schenk, G., Holman, T. and Solomon, E. (2007). Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme. Journal of the American Chemical Society, 129 (24), 7531-7537. doi: 10.1021/ja068503d

An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases

Neves, A., Lanznaster, M., Bortoluzzi, A. J., Peralta, R. A., Casellato, A., Castellano, E. E., Herrald, P., Riley, M. J. and Schenk, G. (2007). An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases. Journal of The American Chemical Society, 129 (24), 7486-7487. doi: 10.1021/ja071184l

Binuclear metallohydrases : emerging drug targets

Schenk, Gerhard (2007). Binuclear metallohydrases : emerging drug targets. Chemistry in Australia, 74 (8), 32-33.

Structure, function and diversity of plant purple acid phosphatases

Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007). Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8, 21-31.

Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site

Jackson, Colin J., Carr, Paul D., Kim, Hye-Kyung, Liu, Jian-Wei, Herrald, Paul, Mitic, Natasa, Schenk, Gerhard, Smith, Clyde A. and Ollis, David L. (2006). Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site. Biochemical Journal, 397 (3), 501-508. doi: 10.1042/BJ20060276

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006). Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 (1), 12-20. doi: 10.1016/j.gene.2006.02.031

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W. and Schenk, G. (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Journal of the Brazilian Chemical Society, 17 (8), 1558-1565. doi: 10.1590/S0103-50532006000800011

Mammalian-like purple acid phosphatases in plants

De Jersey, J., Zheng, Yuan-Zhi, Fan, H. K., Schenk, G., Guddat, L. and Hamilton, S. (2006). Mammalian-like purple acid phosphatases in plants. Chemical Research In Chinese Universities, 22 (2), 263-264. doi: 10.1016/S1005-9040(06)60093-7

The Catalytic Mechanisms of Binuclear Metallohydrolases

Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006). The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 (8), 3338-3363. doi: 10.1021/cr050318f

A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases

Lanznaster, Mauricio, Neves, Ademir, Bortoluzzi, Adailton J., Aires, Veronika V. E., Szpoganicz, Bruno, Terenzi, Hernan, Severino, Patricia C., Fuller, Julie M., Drew, Simon C., Gahan, Lawrence R., Hanson, Graeme R., Riley, Mark J. and Schenk, Gerhard (2005). A New Heterobinuclear FeIIICuII Complex with a Single Terminal FeIII–O(phenolate) Bond. Relevance to Purple Acid Phosphatases and Nucleases. Journal of Biological Inorganic Chemistry, 10 (4), 319-332. doi: 10.1007/s00775-005-0635-7

Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation

Mitic, N., Valizadeh, M., Leung, E. W. W., de Jersey, J., Hamilton, S., Hume, D. A., Cassady, A. I. and Schenk, G. (2005). Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Archives of Biochemistry And Biophysics, 439 (2), 154-164. doi: 10.1016/j.abb.2005.05.013

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase

Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., de Jersey, J. and Guddat, L. W. (2005). Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proceedings of The National Academy of Sciences of The United States of America, 102 (2), 273-278. doi: 10.1073/pnas.0407239102

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004). Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 (2), 154-162. doi: 10.1016/j.abb.2004.01.008

Comparison between the geometric and electronic structures and reactivities of {FeNO}(7) and {FeO2}(8) complexes: A density functional theory study

Schenk, G., Pau, M. Y. M. and Solomon, E. I. (2004). Comparison between the geometric and electronic structures and reactivities of {FeNO}(7) and {FeO2}(8) complexes: A density functional theory study. Journal of The American Chemical Society, 126 (2), 505-515. doi: 10.1021/ja036715u

Direct electrochemistry of porcine purple acid phosphatase (uteroferrin)

Bernhardt, P. V., Schenk, G. and Wilson, G. J. (2004). Direct electrochemistry of porcine purple acid phosphatase (uteroferrin). Biochemistry, 43 (32), 10387-10392. doi: 10.1021/bi0490338

Rapid-freeze-quench magnetic circular dichroism of intermediate X in ribonucleotide reductase: New structural insight

Mitic, N., Saleh, L., Schenk, G., Bollinger, J. Martin Jr. and Solomon, E. I. (2003). Rapid-freeze-quench magnetic circular dichroism of intermediate X in ribonucleotide reductase: New structural insight. Journal of The American Chemical Society, 125 (37), 11200-11201. doi: 10.1021/ja036556e

Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity

Schenk, Gerhard, Neidig, Michael L., Zhou, Jing, Holman, Theodore R. and Solomon, Edward I. (2003). Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity. Biochemistry, 42 (24), 7294-7302. doi: 10.1021/bi027380g

Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate

Twitchett, M. B., Schenk, G., Aquino, M. A. S., Yiu, D. T. Y., Lau, T. C. and Sykes, A. G. (2002). Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate. Inorganic Chemistry, 41 (22), 5787-5794. doi: 10.1021/ic020037f

A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center

Schenk, Gerhard, Boutchard, Clare L., Carrington, Lyle E., Noble, Christopher J., Moubaraki, Boujemaa, Murray, Keith S., de Jersey, John, Hanson, Graeme R. and Hamilton, Susan (2001). A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center. Journal of Biological Chemistry, 276 (22), 19084-19088. doi: 10.1074/jbc.M009778200

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9

Identification of mammalian-like purple acid phosphatases in a wide range of plants

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X

Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato

Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999). Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 (12), 2051-2052. doi: 10.1107/S0907444999012597

Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean

Schenk, G., Ge, Y., Carrington, L., Wynne, C. J., Searle, I. R., Carroll, B. J., Hamilton, S. E. and De Jersey, J. (1999). Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean. Archives of Biochemistry and Biophysics, 370 (2), 183-189. doi: 10.1006/abbi.1999.1407

Heterologous expression of human transketolase

Schenk, G, Duggleby, RG and Nixon, PF (1998). Heterologous expression of human transketolase. International Journal of Biochemistry and Cell Biology, 30 (3), 369-378. doi: 10.1016/S1357-2725(97)00154-4

Properties and functions of the thiamin diphosphate dependent enzyme transketolase

Schenk, G, Duggleby, RG and Nixon, PF (1998). Properties and functions of the thiamin diphosphate dependent enzyme transketolase. International Journal of Biochemistry and Cell Biology, 30 (12), 1297-1318. doi: 10.1016/S1357-2725(98)00095-8

The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis

Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis. European Journal of Biochemistry, 248 (1), 63-71. doi: 10.1111/j.1432-1033.1997.t01-1-00063.x

Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase

Schenk, G, Layfield, R, Candy, JM, Duggleby, RG and Nixon, PF (1997). Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. Journal of Molecular Evolution, 44 (5), 552-572. doi: 10.1007/PL00006179

Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents

Schenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, 31 July - 4 August 2017. New York, NY United States: Springer.

Polymorphisms in Gabra and Rgs Genes Are Associated with Alcoholism and a Secondary Diagnosis of Liver Cirrhosis: Results Are Sex-Linked

Enculescu, C. V., Ho, A. M. C., Rueda, A. V., Fortes, M. R. S., Shamsollahi, G., James, D. P., Schenk, G., Camarini, R., Dodd, P. R. and Stadlin, A. (2017). Polymorphisms in Gabra and Rgs Genes Are Associated with Alcoholism and a Secondary Diagnosis of Liver Cirrhosis: Results Are Sex-Linked. 40th Annual Scientific Meeting of the Research-Society-on-Alcoholism (RSA), Denver CO, United States, 24-28 June 2017. Hoboken, NJ United States: Wiley.

Characterization of novel metallo-beta-lactamases from the B3 subgroup

Miraula, Manfredi, Schenk, Gerhard and Mitić, Nataša (2014). Characterization of novel metallo-beta-lactamases from the B3 subgroup. EuroBIC 12: 12th European Biological Inorganic Chemistry Conference, Zurich, Switzerland, 24-28 August, 2014. Heidelberg, Germany: Springer. doi: 10.1007/s00775-014-1164-z

Kinetics and Structural Analysis of Rv0805 from Mycobacterium tuberculosis

Pedroso, M., Ely, F., Gahan, L. R., Schenk, G., Ollis, D. L. and Larrabee, J. A. (2014). Kinetics and Structural Analysis of Rv0805 from Mycobacterium tuberculosis. 16th International Conference on Biological Inorganic Chemistry (ICBIC), Grenoble France, 22-26 July 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00775-014-1095-8

Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR Spectroscopy

Noble, Christopher J., Gahan, Lawrence R., Schenk, Gerhard and Hanson, Graeme R. (2010). Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR Spectroscopy. World Wide Magnetic Resonance 2010: Joint Euromar 2010 and 17th ISMAR Conference (WWMR2010 ), Florence, Italy, 4-9 July 2010. Florence, Italy: Worldwide Magnetic Resonance Conference.

Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR spectroscopy

Noble, Christopher, Mitic, Natasa, Park, Ah Young, Gahan, Lawrence R., Schenk, Gerhard, Dixon, Nicholas E. and Hanson, Graeme R. (2010). Insights into metal ion mutagenesis and catalysis of dinuclear Mn metallohydrolyases utilizing EPR spectroscopy. 7th Asia-Pacific EPR/ESR Symposium (APES2010), Jeju Island, Republic of Korea, 10-14 October 2010. Daegu, Republic of Korea: Asia-Pacific EPR/ESR Society.

Metal ion mutagenesis – conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site

Mitic, Natasa, Noble, Christopher, Gahan, Lawrence R., Hanson, Graeme R. and Schenk, Gerhard (Gary) (2010). Metal ion mutagenesis – conversion of a purple acid phosphatase from sweet potato to a neutral phosphatase with the formation of an unprecedented catalytically competent MnIIMnII active site. EPR 2010. A Joint Conference of the 14th In Vivo ESR/EPR Spectroscopy & Imaging and the 11th International EPR Spin Trapping/Spin Labeling, San Juan, Puerto Rico, 2-6 May 2010.

Binuclear metallohydrolases: emerging bioremediators and drug targets

Schenk, G., Mitic, N., Gahan, L., Smith, S. and Hadler, K. (2008). Binuclear metallohydrolases: emerging bioremediators and drug targets. 9th European Biological Inorganic Chemistry Conference, Wroclaw, Poland, 2-6 Spetember 2008. Italy: Medimond.

Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes

Noble, Christopher J., Smith, S. J., Mitic, N., Schenk, G., Casselto, A. and Hanson, Graeme R. (2008). Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes. 6th Asia Pacific EPR/ESR Symposium, Cairns, Australia, 13-18 July 2008. St Lucia, Australia: Asia Pacific EPR Society.

Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato

Mitic, N., Noble, C. J., Dixon, N. E., Hanson, G. R. and Schenk, G. (2008). Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato. 6th Asia Pacific EPR/ESR Society Symposium, Cairns, Queensland, Australia, 13-18 July 2008.

Spectroscopic and catalytic properties of uteroferrin and related model systems

Smith, S., Noble, C. J., Hanson, G. R., Riley, M., Schenk, G. and Gahan, L. R. (2008). Spectroscopic and catalytic properties of uteroferrin and related model systems. 6th Asia Pacific EPR/ESR Symposium, Cairns, Queensland, Australia, 13-18 July 2008.

Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ

Gahan, Lawrence R., Hadler, Kieran S., Larrabee, James A., Riley, Mark J. and Schenk, Gerhard (2007). Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0256-4

Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase

Dick, A., Gahan, L. R., Hanson, G., Krausz, E. R., Neves, A., Riley, M. J. and Schenk, G. (2007). Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase. CPC2007: The 6th RACI Conference on Physical Chemistry, Adelaide, South Australia, 28 January - 2 February, 2007.

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases

Aston, Robyn, Boudalis, Athanassios K., Gahan, Lawrence R., Riley, Mark J., Sanakis, Yiannis and Schenk, Gerhard (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0258-2

Biomimetics and a derivative of pig purple acid phosphatase with FeIIINiII binuclear centres

Herrald, P. R., Drew, S. C., Neves, A., Murray, K. S., Moubaraki, B., Mitic, N., Riley, M. J., Hanson, G R, Gahan, L. R. and Schenk, G. (2006). Biomimetics and a derivative of pig purple acid phosphatase with FeIIINiII binuclear centres. 8th European Biological Inorganic Chemistry Conference (EUROBIC 8), Aveiro, Portugal, 2-6 July, 2006.

GA(III) as an analogue of FE(III) in purple acid phosphatases and related model compounds

Smith, S J, Casselato, A., Mitic, N, Riley, M J, Neves, A., Schenk, G and Gahan, L R (2006). GA(III) as an analogue of FE(III) in purple acid phosphatases and related model compounds. 37th Int Conference on Coordination Chemistry, Cape Town, 13-18 Aug, 2006.

Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism

Elliott, Tristan W., Mitić, Nataša, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Sociedade Brasileira de Quimica. doi: 10.1590/S0103-50532006000800011

Substrate analogue induced formation of a binuclear centre in the proof reading 3'-5' exonuclease (e) Subunit of Escherichia coli DNA polymerase III

Mitic, N., Park, A. Y., Dixon, N., Hanson, G. R. and Schenk, G. (2006). Substrate analogue induced formation of a binuclear centre in the proof reading 3'-5' exonuclease (e) Subunit of Escherichia coli DNA polymerase III. 6th Biennial ANZMAG Conference 2006, Murramarang Resort, Murramarang National Park, N.S.W., 12-16 February 2006. Randwick, NSW: ANZMAG.

Characterization of Novel Metal Centers in Purple Acid Phosphatases and Related Model Complexes

Mitic, Natasa, Herrald, Paul, Drew, Simon C., Gahan, Lawrence R., Riley, Mark J., Neves, Ademir, Schenk, Gerhard and Hanson, Graeme R. (2005). Characterization of Novel Metal Centers in Purple Acid Phosphatases and Related Model Complexes. 12th International Conference on Biological Inorganic Chemistry, University of Michigan, Department of Chemistry, Ann Arbor, MI, July 31- August 5, 2005.

Magnetic circular dichroism spectroscopy of a bimetallic purple acid phosphatase mimic

Dick, A. K., Riley, M. J., Krausz, E. R. and Schenk, G. (2005). Magnetic circular dichroism spectroscopy of a bimetallic purple acid phosphatase mimic. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, 3-7 July 2005. Melbourne, Vic., Australia: Royal Australian Chemical Institute (RACI).

Model complexes of purple acid phosphatases

Smith, S. J., Gahan, L. R., Schenk, G. and Riley, M. J. (2005). Model complexes of purple acid phosphatases. Connect 2005: 12th RACI Convention, Sydney, N.S.W., Australia, 3-7 July 2005. Melbourne, Vic., Australia: Royal Australian Chemical Institute (RACI).

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre

Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.

Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins

Hanson, G. R., Schenk, G. and Noble, C. J. (2000). Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins. 42nd Rocky Mountain Conference on Analytical Chemistry, Broomfield, Colorado, USA, 30 July - 3 August, 2000. USA: Milestone Presentations.

Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein

Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. EUROBIC-5, Toulouse, France, 17-20 July 2000.

The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins

Noble, C. J., Hanson, G. R. and Schenk, G. (2000). The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins. ANZMAG 2000, Mt Buller, Vic, 13-17 February 2000. Melbourne, Vic: ANZMAG.

Planrtpurple acid phosphatases: Novel forms of the enzyme

Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening

Hanson, G. R., Noble, C. J., Schenk, G., Hamilton, S. E., Boutchard, C. and De Jersey, J. (1999). Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening. 41st Rocky Mountain Conference on Analytical Chemistry, Denver, 1st - 5th August, 2000. Denver: American Chemical Society.

Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening

Hanson, G. R., Noble, C. J., Boutchard, C., Schenk, G., Hamilton, S. E. and De Jersey, J. (1999). Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening. 2nd Asia-Pacific EPR/ESR Symposium Proceedings, Hangzhou, China, 31 October - 4 November 1999. China: Asia Pacific EPR/ESR Society.

Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre

Schenk, G., Carrington, L., Hanson, G. R., De Jersey, J. and Hamilton, S. E. (1999). Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre. Specialist Meeting on Enzyme Structure and Mechanism, Kurong Resort, Fraser Island, 22-25 September, 1999. Brisbane: Univ. of Qld.

Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy

Boutchard, C.L., Carrington, L., Schenk, G., Noble, C.J., Hanson, G.R., Hamilton, S.E., de Jersey, J. and Gahan, L.R. (1998). Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy. A joint 29th AMPERE — 13th ISMAR International Conference on Magnetic Resonance and Related Phenomena Revisited, Berlin, Germany, 2-7 August, 1998. Berlin, Germany: Springer Wien. doi: 10.1007/BF03162015

Investigation of the mechanistic functions of residues HIS113 and HIS114 in pyruvate decarboxylase from Zymomonas mobilis: A proposed model in the binding of the substrate pyruvate

Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). Investigation of the mechanistic functions of residues HIS113 and HIS114 in pyruvate decarboxylase from Zymomonas mobilis: A proposed model in the binding of the substrate pyruvate. Unknown, Unknown, Unknown. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.

Genomic resources of seven Australian weed species of national significance

Shah, Sarah, Lonhienne, Thierry, Murray, Cody-Ellen, Chen, Yibi, Dougan, Katherine E., Low, Yu Shang, Williams, Craig M., Schenk, Gerhard, Walter, Gimme H., Guddat, Luke W. and Chan, Cheong Xin (2022). Genomic resources of seven Australian weed species of national significance. The University of Queensland. (Dataset) doi: 10.48610/c22c10c

SR-SIM raw data - GFP and mRuby3 co-encapsulation

Cheah, Li Chen, Vickers, Claudia, Sainsbury, Frank, Cheah, Li Chen, Sainsbury, Frank, Schenk, Gary and Vickers, Claudia (2022). SR-SIM raw data - GFP and mRuby3 co-encapsulation. The University of Queensland. (Dataset) doi: 10.48610/cf92aa5

Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes

Cheah, Li Chen, Vickers, Claudia, Sainsbury, Frank, Cheah, Li Chen, Sainsbury, Frank, Schenk, Gary and Vickers, Claudia (2022). Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes. The University of Queensland. (Dataset) doi: 10.48610/eab4972

Studies on the thiamin-dependent enzymes transketolase and pyruvate decarboxylase

Schenk, Gerhard (1997). Studies on the thiamin-dependent enzymes transketolase and pyruvate decarboxylase. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/7bd3260