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Metallo-beta-lactamases: predicting and combating antibiotic resistance. (2010–2013)

Abstract:
The increase of drug-resistant bacterial pathogens has become a major global health concern. Many pathogens employ a special enzyme, named metallo-beta-lactamese (MBL), to degrade antibiotics such as penecillin. No clinically useful inhibitors of this enzyme are available. We will use sophisticated techniques to predict and combat drug resistance of the MBL from Klebsiella pneumoniae, a pathogen associated in particular with hospital-acquired infections such as urinary tract infections.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Gary Schenk

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Professor
    Australian Institute for Bioengineering and Nanotechnology

  • Professor Mark Schembri

    Professorial Research Fellow & Grou
    Institute for Molecular Bioscience
    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
National Health and Medical Research Council