The University of Queensland

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency

Turnbull, Cynthia, Bones, Josiah, Stanley, Maurice, Medhavy, Arti, Wang, Hao, Lorenzo, Ayla May D., Cappello, Jean, Shanmuganandam, Somasundhari, Pandey, Abhimanu, Seneviratne, Sandali, Brown, Grant J, Meng, Xiangpeng, Fulcher, David, Burgio, Gaetan, Man, Si Ming, de Lucas Collantes, Carmen, Gasior, Mercedes, López Granados, Eduardo, Martin, Pilar, Jiang, Simon H., Cook, Matthew C., Ellyard, Julia I., Athanasopoulos, Vicki, Corry, Ben, Canete, Pablo F. and Vinuesa, Carola G. (2023). DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency. Science Advances, 9 (49) ARTN eadi9566, eadi9566. doi: 10.1126/sciadv.adi9566

Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives

Nettelfield, Sam, Yu, Di and Cañete, Pablo F (2023). Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives. International Immunology, 35 (12), 571-582. doi: 10.1093/intimm/dxad021

CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells

Hao, Yuwei, Miraghazadeh, Bahar, Chand, Rochna, Davies, Ainsley R., Cardinez, Chelisa, Kwong, Kristy, Downes, Morgan B., Sweet, Rebecca A., Cañete, Pablo F., D’Orsogna, Lloyd J., Fulcher, David A., Choo, Sharon, Yip, Desmond, Peters, Geoffrey, Yip, Sonia, Witney, Matthew J., Nekrasov, Maxim, Feng, Zhi-Ping, Tscharke, David C., Vinuesa, Carola G. and Cook, Matthew C. (2023). CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells. Cellular and Molecular Immunology, 20 (7), 1-17. doi: 10.1038/s41423-023-01027-8

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

Extrafollicular plasmablasts present in the acute phase of infections express high levels of PD-L1 and are able to limit T cell response

Serrán, Melisa Gorosito, Vernengo, Facundo Fiocca, Almada, Laura, Beccaria, Cristian G., Gazzoni, Yamila, Canete, Pablo F., Roco, Jonathan A., Boari, Jimena Tosello, Ramello, Maria Cecilia, Wehrens, Ellen, Cai, Yeping, Zuniga, Elina I., Montes, Carolina L., Cockburn, Ian A., Rodriguez, Eva V. Acosta, Vinuesa, Carola G. and Gruppi, Adriana (2022). Extrafollicular plasmablasts present in the acute phase of infections express high levels of PD-L1 and are able to limit T cell response. Frontiers in Immunology, 13 828734, 1-13. doi: 10.3389/fimmu.2022.828734

TLR7 gain-of-function genetic variation causes human lupus

Brown, Grant J., Cañete, Pablo F., Wang, Hao, Medhavy, Arti, Bones, Josiah, Roco, Jonathan A., He, Yuke, Qin, Yuting, Cappello, Jean, Ellyard, Julia I., Bassett, Katharine, Shen, Qian, Burgio, Gaetan, Zhang, Yaoyuan, Turnbull, Cynthia, Meng, Xiangpeng, Wu, Phil, Cho, Eun, Miosge, Lisa A., Andrews, T. Daniel, Field, Matt A., Tvorogov, Denis, Lopez, Angel F., Babon, Jeffrey J., López, Cristina Aparicio, Gónzalez-Murillo, África, Garulo, Daniel Clemente, Pascual, Virginia, Levy, Tess ... Vinuesa, Carola G. (2022). TLR7 gain-of-function genetic variation causes human lupus. Nature, 605 (7909), 349-356. doi: 10.1038/s41586-022-04642-z

Evolution of γ chain cytokines: mechanisms, methods and applications

Antczak, Magdalena, Cañete, Pablo F., Chen, Zhian, Belle, Clémence and Yu, Di (2022). Evolution of γ chain cytokines: mechanisms, methods and applications. Computational and Structural Biotechnology Journal, 20, 4746-4755. doi: 10.1016/j.csbj.2022.08.050

Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease

Jiang, Simon H., Mercan, Sevcan, Papa, Ilenia, Moldovan, Max, Walters, Giles D., Koina, Mark, Fadia, Mitali, Stanley, Maurice, Lea-Henry, Tom, Cook, Amelia, Ellyard, Julia, McMorran, Brendan, Sundaram, Madhivanan, Thomson, Russell, Canete, Pablo F., Hoy, Wendy, Hutton, Holly, Srivastava, Monika, McKeon, Kathryn, de la Rúa Figueroa, Iñigo, Cervera, Ricard, Faria, Raquel, D'Alfonso, Sandra, Gatto, Mariele, Athanasopoulos, Vicki, Field, Matthew, Mathews, John, Cho, Eun, Andrews, Thomas D. ... Vinuesa, Carola G. (2021). Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease. Cell Reports Medicine, 2 (12) 100475, 100475. doi: 10.1016/j.xcrm.2021.100475

Follicular regulatory T cells produce neuritin to regulate B cells

Gonzalez-Figueroa, Paula, Roco, Jonathan A., Papa, Ilenia, Núñez Villacís, Lorena, Stanley, Maurice, Linterman, Michelle A., Dent, Alexander, Canete, Pablo F. and Vinuesa, Carola G. (2021). Follicular regulatory T cells produce neuritin to regulate B cells. Cell, 184 (7), 1775-1789.e19. doi: 10.1016/j.cell.2021.02.027

COVID-19 Makes B Cells Forget, but T Cells Remember

Cañete, Pablo F. and Vinuesa, Carola G. (2020). COVID-19 Makes B Cells Forget, but T Cells Remember. Cell, 183 (1), 13-15. doi: 10.1016/j.cell.2020.09.013

Class-switch recombination occurs infrequently in germinal centers

Roco, Jonathan A., Mesin, Luka, Binder, Sebastian C., Nefzger, Christian, Gonzalez-Figueroa, Paula, Canete, Pablo F., Ellyard, Julia, Shen, Qian, Robert, Philippe A., Cappello, Jean, Vohra, Harpreet, Zhang, Yang, Nowosad, Carla R., Schiepers, Arien, Corcoran, Lynn M., Toellner, Kai-Michael, Polo, Jose M., Meyer-Hermann, Michael, Victora, Gabriel D. and Vinuesa, Carola G. (2019). Class-switch recombination occurs infrequently in germinal centers. Immunity, 51 (2), 337-350.e7. doi: 10.1016/j.immuni.2019.07.001

Regulatory roles of IL-10–producing human follicular T cells

Cañete, Pablo F., Sweet, Rebecca A., Gonzalez-Figueroa, Paula, Papa, Ilenia, Ohkura, Naganari, Bolton, Holly, Roco, Jonathan A., Cuenca, Marta, Bassett, Katharine J., Sayin, Ismail, Barry, Emma, Lopez, Angel, Canaday, David H., Meyer-Hermann, Michael, Doglioni, Claudio, Fazekas de St Groth, Barbara, Sakaguchi, Shimon, Cook, Matthew C. and Vinuesa, Carola G. (2019). Regulatory roles of IL-10–producing human follicular T cells. Journal of Experimental Medicine, 216 (8), 1843-1856. doi: 10.1084/jem.20190493

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Jiang, Simon H., Athanasopoulos, Vicki, Ellyard, Julia I., Chuah, Aaron, Cappello, Jean, Cook, Amelia, Prabhu, Savit B., Cardenas, Jacob, Gu, Jinghua, Stanley, Maurice, Roco, Jonathan A., Papa, Ilenia, Yabas, Mehmet, Walters, Giles D., Burgio, Gaetan, McKeon, Kathryn, Byers, James M., Burrin, Charlotte, Enders, Anselm, Miosge, Lisa A., Canete, Pablo F., Jelusic, Marija, Tasic, Velibor, Lungu, Adrian C., Alexander, Stephen I., Kitching, Arthur R., Fulcher, David A., Shen, Nan, Arsov, Todor ... Vinuesa, Carola G. (2019). Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Nature Communications, 10 (1) 2201. doi: 10.1038/s41467-019-10242-9

TFH-derived dopamine accelerates productive synapses in germinal centres

Papa, Ilenia, Saliba, David, Ponzoni, Maurilio, Bustamante, Sonia, Canete, Pablo F., Gonzalez-Figueroa, Paula, McNamara, Hayley A., Valvo, Salvatore, Grimbaldeston, Michele, Sweet, Rebecca A., Vohra, Harpreet, Cockburn, Ian A., Meyer-Hermann, Michael, Dustin, Michael L., Doglioni, Claudio and Vinuesa, Carola G. (2017). TFH-derived dopamine accelerates productive synapses in germinal centres. Nature, 547 (7663), 318-323. doi: 10.1038/nature23013

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

Jandl, Christoph, Liu, Sue M., Cañete, Pablo F., Warren, Joanna, Hughes, William E., Vogelzang, Alexis, Webster, Kylie, Craig, Maria E., Uzel, Gulbu, Dent, Alexander, Stepensky, Polina, Keller, Bärbel, Warnatz, Klaus, Sprent, Jonathan and King, Cecile (2017). IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2. Nature Communications, 8 (1) 14647. doi: 10.1038/ncomms14647

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Ramiscal, Roybel R, Parish, Ian A, Lee-Young, Robert S, Babon, Jeffrey J, Blagih, Julianna, Pratama, Alvin, Martin, Jaime, Hawley, Naomi, Cappello, Jean Y, Nieto, Pablo F, Ellyard, Julia I, Kershaw, Nadia J, Sweet, Rebecca A, Goodnow, Christopher C, Jones, Russell G, Febbraio, Mark A, Vinuesa, Carola G and Athanasopoulos, Vicki (2015). Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation. eLife, 4 (OCTOBER2015) 08698, 1-22. doi: 10.7554/elife.08698