Dr Pablo Canete

Research Fellow

Frazer Institute
Faculty of Medicine

Research Fellow

Frazer Institute
Faculty of Medicine

Overview

Dr. Pablo Cañete was awarded a PhD in Immunology in 2019 under Prof. Carola Vinuesa’s supervision at the John Curtin School of Medical Research (JCSMR), The Australian National University (ANU). During this time he characterised a novel human T cell subset important for modulating antibodies associated with allergic responses. His doctoral research has been recognised by several awards, including the prestigious Dewar Milne prize for immunology, awarded to the most outstanding PhD thesis of Immunology at the JCSMR, ANU. He then continued as a postdoc with Prof. Vinuesa investigating 1) novel tolerance mechanisms and 2) characterising bespoke mouse models of autoimmunity at the Centre for Personalised Immunology. In 2022 he joined Frazer institute with Prof. Di Yu where he hopes to uncover novel approaches for harnessing T cell biology for therapeutic purposes. Pablo’s research vision is to integrate human and mouse immunology together with systems biology with the hope to better understand antibody responses, mechanisms of immune tolerance and autoimmunity.

Research Interests

  • Humoral Immunity
  • Autoimmunity
  • Regulatory T cells

Publications

  • Turnbull, Cynthia, Bones, Josiah, Stanley, Maurice, Medhavy, Arti, Wang, Hao, Lorenzo, Ayla May D., Cappello, Jean, Shanmuganandam, Somasundhari, Pandey, Abhimanu, Seneviratne, Sandali, Brown, Grant J., Meng, Xiangpeng, Fulcher, David, Burgio, Gaetan, Man, Si Ming, de Lucas Collantes, Carmen, Gasior, Mercedes, López Granados, Eduardo, Martin, Pilar, Jiang, Simon H., Cook, Matthew C., Ellyard, Julia I., Athanasopoulos, Vicki, Corry, Ben, Canete, Pablo F. and Vinuesa, Carola G. (2023). DECTIN-1: a modifier protein in CTLA-4 haploinsufficiency. Science Advances, 9 (49) eadi9566, 1-14. doi: 10.1126/sciadv.adi9566

  • Nettelfield, Sam, Yu, Di and Cañete, Pablo F (2023). Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives. International Immunology, 35 (12), 571-582. doi: 10.1093/intimm/dxad021

  • Hao, Yuwei, Miraghazadeh, Bahar, Chand, Rochna, Davies, Ainsley R., Cardinez, Chelisa, Kwong, Kristy, Downes, Morgan B., Sweet, Rebecca A., Cañete, Pablo F., D’Orsogna, Lloyd J., Fulcher, David A., Choo, Sharon, Yip, Desmond, Peters, Geoffrey, Yip, Sonia, Witney, Matthew J., Nekrasov, Maxim, Feng, Zhi-Ping, Tscharke, David C., Vinuesa, Carola G. and Cook, Matthew C. (2023). CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells. Cellular and Molecular Immunology, 20 (7), 1-17. doi: 10.1038/s41423-023-01027-8

View all Publications

Supervision

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

  • Turnbull, Cynthia, Bones, Josiah, Stanley, Maurice, Medhavy, Arti, Wang, Hao, Lorenzo, Ayla May D., Cappello, Jean, Shanmuganandam, Somasundhari, Pandey, Abhimanu, Seneviratne, Sandali, Brown, Grant J., Meng, Xiangpeng, Fulcher, David, Burgio, Gaetan, Man, Si Ming, de Lucas Collantes, Carmen, Gasior, Mercedes, López Granados, Eduardo, Martin, Pilar, Jiang, Simon H., Cook, Matthew C., Ellyard, Julia I., Athanasopoulos, Vicki, Corry, Ben, Canete, Pablo F. and Vinuesa, Carola G. (2023). DECTIN-1: a modifier protein in CTLA-4 haploinsufficiency. Science Advances, 9 (49) eadi9566, 1-14. doi: 10.1126/sciadv.adi9566

  • Nettelfield, Sam, Yu, Di and Cañete, Pablo F (2023). Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives. International Immunology, 35 (12), 571-582. doi: 10.1093/intimm/dxad021

  • Hao, Yuwei, Miraghazadeh, Bahar, Chand, Rochna, Davies, Ainsley R., Cardinez, Chelisa, Kwong, Kristy, Downes, Morgan B., Sweet, Rebecca A., Cañete, Pablo F., D’Orsogna, Lloyd J., Fulcher, David A., Choo, Sharon, Yip, Desmond, Peters, Geoffrey, Yip, Sonia, Witney, Matthew J., Nekrasov, Maxim, Feng, Zhi-Ping, Tscharke, David C., Vinuesa, Carola G. and Cook, Matthew C. (2023). CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells. Cellular and Molecular Immunology, 20 (7), 1-17. doi: 10.1038/s41423-023-01027-8

  • Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

  • Serrán, Melisa Gorosito, Vernengo, Facundo Fiocca, Almada, Laura, Beccaria, Cristian G., Gazzoni, Yamila, Canete, Pablo F., Roco, Jonathan A., Boari, Jimena Tosello, Ramello, Maria Cecilia, Wehrens, Ellen, Cai, Yeping, Zuniga, Elina I., Montes, Carolina L., Cockburn, Ian A., Rodriguez, Eva V. Acosta, Vinuesa, Carola G. and Gruppi, Adriana (2022). Extrafollicular plasmablasts present in the acute phase of infections express high levels of PD-L1 and are able to limit T cell response. Frontiers in Immunology, 13 828734, 1-13. doi: 10.3389/fimmu.2022.828734

  • Brown, Grant J., Cañete, Pablo F., Wang, Hao, Medhavy, Arti, Bones, Josiah, Roco, Jonathan A., He, Yuke, Qin, Yuting, Cappello, Jean, Ellyard, Julia I., Bassett, Katharine, Shen, Qian, Burgio, Gaetan, Zhang, Yaoyuan, Turnbull, Cynthia, Meng, Xiangpeng, Wu, Phil, Cho, Eun, Miosge, Lisa A., Andrews, T. Daniel, Field, Matt A., Tvorogov, Denis, Lopez, Angel F., Babon, Jeffrey J., López, Cristina Aparicio, Gónzalez-Murillo, África, Garulo, Daniel Clemente, Pascual, Virginia, Levy, Tess ... Vinuesa, Carola G. (2022). TLR7 gain-of-function genetic variation causes human lupus. Nature, 605 (7909), 349-356. doi: 10.1038/s41586-022-04642-z

  • Antczak, Magdalena, Cañete, Pablo F., Chen, Zhian, Belle, Clémence and Yu, Di (2022). Evolution of γ chain cytokines: mechanisms, methods and applications. Computational and Structural Biotechnology Journal, 20, 4746-4755. doi: 10.1016/j.csbj.2022.08.050

  • Jiang, Simon H., Mercan, Sevcan, Papa, Ilenia, Moldovan, Max, Walters, Giles D., Koina, Mark, Fadia, Mitali, Stanley, Maurice, Lea-Henry, Tom, Cook, Amelia, Ellyard, Julia, McMorran, Brendan, Sundaram, Madhivanan, Thomson, Russell, Canete, Pablo F., Hoy, Wendy, Hutton, Holly, Srivastava, Monika, McKeon, Kathryn, de la Rúa Figueroa, Iñigo, Cervera, Ricard, Faria, Raquel, D'Alfonso, Sandra, Gatto, Mariele, Athanasopoulos, Vicki, Field, Matthew, Mathews, John, Cho, Eun, Andrews, Thomas D. ... Vinuesa, Carola G. (2021). Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease. Cell Reports Medicine, 2 (12) 100475, 100475. doi: 10.1016/j.xcrm.2021.100475

  • Gonzalez-Figueroa, Paula, Roco, Jonathan A., Papa, Ilenia, Núñez Villacís, Lorena, Stanley, Maurice, Linterman, Michelle A., Dent, Alexander, Canete, Pablo F. and Vinuesa, Carola G. (2021). Follicular regulatory T cells produce neuritin to regulate B cells. Cell, 184 (7), 1775-1789.e19. doi: 10.1016/j.cell.2021.02.027

  • Cañete, Pablo F. and Vinuesa, Carola G. (2020). COVID-19 Makes B Cells Forget, but T Cells Remember. Cell, 183 (1), 13-15. doi: 10.1016/j.cell.2020.09.013

  • Roco, Jonathan A., Mesin, Luka, Binder, Sebastian C., Nefzger, Christian, Gonzalez-Figueroa, Paula, Canete, Pablo F., Ellyard, Julia, Shen, Qian, Robert, Philippe A., Cappello, Jean, Vohra, Harpreet, Zhang, Yang, Nowosad, Carla R., Schiepers, Arien, Corcoran, Lynn M., Toellner, Kai-Michael, Polo, Jose M., Meyer-Hermann, Michael, Victora, Gabriel D. and Vinuesa, Carola G. (2019). Class-switch recombination occurs infrequently in germinal centers. Immunity, 51 (2), 337-350.e7. doi: 10.1016/j.immuni.2019.07.001

  • Cañete, Pablo F., Sweet, Rebecca A., Gonzalez-Figueroa, Paula, Papa, Ilenia, Ohkura, Naganari, Bolton, Holly, Roco, Jonathan A., Cuenca, Marta, Bassett, Katharine J., Sayin, Ismail, Barry, Emma, Lopez, Angel, Canaday, David H., Meyer-Hermann, Michael, Doglioni, Claudio, Fazekas de St Groth, Barbara, Sakaguchi, Shimon, Cook, Matthew C. and Vinuesa, Carola G. (2019). Regulatory roles of IL-10–producing human follicular T cells. Journal of Experimental Medicine, 216 (8), 1843-1856. doi: 10.1084/jem.20190493

  • Jiang, Simon H., Athanasopoulos, Vicki, Ellyard, Julia I., Chuah, Aaron, Cappello, Jean, Cook, Amelia, Prabhu, Savit B., Cardenas, Jacob, Gu, Jinghua, Stanley, Maurice, Roco, Jonathan A., Papa, Ilenia, Yabas, Mehmet, Walters, Giles D., Burgio, Gaetan, McKeon, Kathryn, Byers, James M., Burrin, Charlotte, Enders, Anselm, Miosge, Lisa A., Canete, Pablo F., Jelusic, Marija, Tasic, Velibor, Lungu, Adrian C., Alexander, Stephen I., Kitching, Arthur R., Fulcher, David A., Shen, Nan, Arsov, Todor ... Vinuesa, Carola G. (2019). Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Nature Communications, 10 (1) 2201. doi: 10.1038/s41467-019-10242-9

  • Papa, Ilenia, Saliba, David, Ponzoni, Maurilio, Bustamante, Sonia, Canete, Pablo F., Gonzalez-Figueroa, Paula, McNamara, Hayley A., Valvo, Salvatore, Grimbaldeston, Michele, Sweet, Rebecca A., Vohra, Harpreet, Cockburn, Ian A., Meyer-Hermann, Michael, Dustin, Michael L., Doglioni, Claudio and Vinuesa, Carola G. (2017). TFH-derived dopamine accelerates productive synapses in germinal centres. Nature, 547 (7663), 318-323. doi: 10.1038/nature23013

  • Jandl, Christoph, Liu, Sue M., Cañete, Pablo F., Warren, Joanna, Hughes, William E., Vogelzang, Alexis, Webster, Kylie, Craig, Maria E., Uzel, Gulbu, Dent, Alexander, Stepensky, Polina, Keller, Bärbel, Warnatz, Klaus, Sprent, Jonathan and King, Cecile (2017). IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2. Nature Communications, 8 (1) 14647. doi: 10.1038/ncomms14647

  • Ramiscal, Roybel R, Parish, Ian A, Lee-Young, Robert S, Babon, Jeffrey J, Blagih, Julianna, Pratama, Alvin, Martin, Jaime, Hawley, Naomi, Cappello, Jean Y, Nieto, Pablo F, Ellyard, Julia I, Kershaw, Nadia J, Sweet, Rebecca A, Goodnow, Christopher C, Jones, Russell G, Febbraio, Mark A, Vinuesa, Carola G and Athanasopoulos, Vicki (2015). Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation. eLife, 4 (OCTOBER2015) 08698, 1-22. doi: 10.7554/elife.08698

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Associate Advisor

    Other advisors: