The University of Queensland

Therapeutic modulation of T follicular helper cells by low-dose IL-2 treatment

Chen, Zhian, Liang, Kaili, Deng, Jun and Yu, Di (2022). Therapeutic modulation of T follicular helper cells by low-dose IL-2 treatment. T-follicular helper cells: methods and protocols. (pp. 255-265) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1736-6_21

Ex vivo culture assay to measure human follicular helper T (Tfh) cell-mediated human B cell proliferation and differentiation

Gao, Xin, Lin, Lin and Yu, Di (2018). Ex vivo culture assay to measure human follicular helper T (Tfh) cell-mediated human B cell proliferation and differentiation. Methods in bolecular biology. (pp. 111-119) New York, NY USA: Springer New York. doi: 10.1007/978-1-4939-7474-0_8

Roquin defects reveal a role for the MicroRNA machinery in regulating autoimmunity

Yu, Di and Vinuesa, Carola G. (2009). Roquin defects reveal a role for the MicroRNA machinery in regulating autoimmunity. The Epigenetics of Autoimmune Diseases. (pp. 261-278) edited by Moncef Zouali. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/9780470743553.ch15

A Galectin-9–Driven CD11c ^high Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia

Li, Yanhong, Sang, Yifei, Chang, Yunjian, Xu, Chunfang, Lin, Yikong, Zhang, Yao, Chiu, Philip C.N., Yeung, William S.B., Zhou, Haisheng, Dong, Ningzheng, Xu, Ling, Chen, Jiajia, Zhao, Weijie, Liu, Lu, Yu, Di, Zang, Xingxing, Ye, Jiangfeng, Yang, Jinying, Wu, Qingyu, Li, Dajin, Wu, Ligang and Du, Meirong (2024). A Galectin-9–Driven CD11c high Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia. Circulation. doi: 10.1161/circulationaha.123.064391

Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization

Ye, Tong, Jiao, Zhouguang, Li, Xin, He, Zhanlong, Li, Yanyan, Yang, Fengmei, Zhao, Xin, Wang, Youchun, Huang, Weijin, Qin, Meng, Feng, Yingmei, Qiu, Yefeng, Yang, Wenhui, Hu, Lingfei, Hu, Yaling, Zhai, Yu, Wang, Erqiang, Yu, Di, Wang, Shuang, Yue, Hua, Wang, Yishu, Wang, Hengliang, Zhu, Li, Ma, Guanghui and Wei, Wei (2023). Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization. Nature, 624 (7992), 630-638. doi: 10.1038/s41586-023-06809-8

Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives

Nettelfield, Sam, Yu, Di and Cañete, Pablo F (2023). Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives. International Immunology, 35 (12), 571-582. doi: 10.1093/intimm/dxad021

Low-dose IL-2 Treatment Rescues Cognitive Deficits by Repairing the Imbalance Between Treg and Th17 Cells at the Middle Alzheimer’s Disease Stage

Yuan, Lin, Xie, Lei, Zhang, Hao, Zhang, Yu, Wei, Yunbo, Feng, Jinhong, Cui, Li, Tian, Rui, Feng, Jia, Yu, Di and Lv, Cui (2023). Low-dose IL-2 Treatment Rescues Cognitive Deficits by Repairing the Imbalance Between Treg and Th17 Cells at the Middle Alzheimer’s Disease Stage. Journal of Neuroimmune Pharmacology, 18 (4), 674-689. doi: 10.1007/s11481-023-10090-x

Autoimmune uveitis in Behçet's disease and Vogt‐Koyanagi‐Harada disease differ in tissue immune infiltration and T cell clonality

Kang, Hao, Sun, Hongjian, Yang, Yang, Tuong, Zewen K., Shu, Minglei, Wei, Yunbo, Zhang, Yu, Yu, Di and Tao, Yong (2023). Autoimmune uveitis in Behçet's disease and Vogt‐Koyanagi‐Harada disease differ in tissue immune infiltration and T cell clonality. Clinical and Translational Immunology, 12 (9) e1461, 1-17. doi: 10.1002/cti2.1461

Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation

Yunis, Joseph, Short, Kirsty R. and Yu, Di (2023). Severe respiratory viral infections: T-cell functions diverging from immunity to inflammation. Trends in Microbiology, 31 (6), 644-656. doi: 10.1016/j.tim.2022.12.008

Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease

Chen, Titi, Cao, Qi, Wang, Ruifeng, Zheng, Guoping, Azmi, Farhana, Lee, Vincent W., Wang, Yuan Ming, Li, Hongqi, Yu, Di, Rogers, Natasha M., Alexander, Stephen I., Harris, David C.H. and Wang, Yiping (2023). Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease. Clinical Immunology, 250 109295, 1-14. doi: 10.1016/j.clim.2023.109295

Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Chen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728

T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance

Gao, Xin, Luo, Kaiming, Wang, Diya, Wei, Yunbo, Yao, Yin, Deng, Jun, Yang, Yang, Zeng, Qunxiong, Dong, Xiaoru, Xiong, Le, Gong, Dongcheng, Lin, Lin, Pohl, Kai, Liu, Shaoling, Liu, Yu, Liu, Lu, Nguyen, Thi HO, Allen, Lilith F., Kedzierska, Katherine, Jin, Yanliang, Du, Mei-Rong, Chen, Wanping, Lu, Liangjing, Shen, Nan, Liu, Zheng, Cockburn, Ian A., Luo, Wenjing and Yu, Di (2023). T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance. eLife, 12 e82217, 1-29. doi: 10.7554/elife.82217

Dimensionality reduction under scrutiny

Yang, Yang, Tuong, Zewen K. and Yu, Di (2023). Dimensionality reduction under scrutiny. Nature Computational Science, 3 (1), 8-9. doi: 10.1038/s43588-022-00383-1

Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease

Gong, Huanle, Ma, Shoubao, Chen, Jia, Yang, Bingyu, Liu, Shuangzhu, Liu, Xin, Han, Jingjing, Wu, Xiaojin, Lei, Lei, Yin, Zhinan, Sun, Hongjian, Yu, Di, Liu, Haiyan, Xu, Yang and Wu, Depei (2022). Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease. Signal Transduction and Targeted Therapy, 7 (1) 319, 1-12. doi: 10.1038/s41392-022-01147-z

LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus

Liu, Limin, Hu, Longyuan, Long, Haojun, Zheng, Meiling, Hu, Zhi, He, Ye, Gao, Xiaofei, Du, Pei, Zhao, Hongjun, Yu, Di, Lu, Qianjin and Zhao, Ming (2022). LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus. Clinical and Translational Medicine, 12 (12) e1117, 1-21. doi: 10.1002/ctm2.1117

Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial

He, Jing, Chen, Jiali, Miao, Miao, Zhang, Ruijun, Cheng, Gong, Wang, Yifan, Feng, Ruiling, Huang, Bo, Luan, Huijie, Jia, Yuan, Jin, Yuebo, Zhang, Xiaoying, Shao, Miao, Wang, Yu, Zhang, Xia, Li, Jing, Zhao, Xiaozhen, Wang, Han, Liu, Tian, Xiao, Xian, Zhang, Xuewu, Su, Yin, Mu, Rong, Ye, Hua, Li, Ru, Liu, Xu, Liu, Yanying, Li, Chun, Liu, Huixin ... Li, Zhanguo (2022). Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial. JAMA Network Open, 5 (11) e2241451, 1-16. doi: 10.1001/jamanetworkopen.2022.41451

Allergen Immunotherapy Reverses Immune Response to SARS-CoV-2 Vaccine in Patients with Allergic Rhinitis: A Prospective Observational Trial

Yao, Yin, Huang, Ao, Deng, Yi-Ke, Liu, Yan, Zhu, Hong-Yu, Wang, Nan, Wang, Zhe-Zheng, Zhu, Rong-Fei, Yu, Di and Liu, Zheng (2022). Allergen Immunotherapy Reverses Immune Response to SARS-CoV-2 Vaccine in Patients with Allergic Rhinitis: A Prospective Observational Trial. American Journal of Respiratory and Critical Care Medicine, 206 (6), 780-783. doi: 10.1164/rccm.202203-0608le

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses

Zhang, Lei, Jiang, Li, Yu, Liang, Li, Qin, Tian, Xiangjun, He, Jingquan, Zeng, Ling, Yang, Yuqin, Wang, Chaoran, Wei, Yuhan, Jiang, Xiaoyue, Li, Jing, Ge, Xiaolu, Gu, Qisheng, Li, Jikun, Wu, Di, Sadler, Anthony J., Yu, Di, Xu, Dakang, Gao, Yue, Yuan, Xiangliang and He, Baokun (2022). Inhibition of UBA6 by inosine augments tumour immunogenicity and responses. Nature Communications, 13 (1) 5413, 1-16. doi: 10.1038/s41467-022-33116-z

Targeting TFH cells in human diseases and vaccination: rationale and practice

Yu, Di, Walker, Lucy S. K., Liu, Zheng, Linterman, Michelle A. and Li, Zhanguo (2022). Targeting TFH cells in human diseases and vaccination: rationale and practice. Nature Immunology, 23 (8), 1157-1168. doi: 10.1038/s41590-022-01253-8

Integrative analysis of small RNA and mRNA expression profiles identifies signatures associated with chronic epididymitis

Gong, Jialei, Wang, Peng, Liu, Jin-Chuan, Li, Jianlin, Zeng, Qun-Xiong, Yang, Chen, Li, Yanfeng, Yu, Di, Cao, Dandan and Duan, Yong-Gang (2022). Integrative analysis of small RNA and mRNA expression profiles identifies signatures associated with chronic epididymitis. Frontiers in Immunology, 13 883803, 1-12. doi: 10.3389/fimmu.2022.883803

Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus

Gao, Xiaofei, Song, Yang, Wu, Jiali, Lu, Shuang, Min, Xiaoli, Liu, Limin, Hu, Longyuan, Zheng, Meiling, Du, Pei, Yu, Yaqin, Long, Hai, Wu, Haijing, Jia, Sujie, Yu, Di, Lu, Qianjin and Zhao, Ming (2022). Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. Journal of Clinical Investigation, 132 (9) e152345. doi: 10.1172/JCI152345

Context-dependent regulation of follicular helper T cell survival

Chen, Zhian, Wang, Naiqi, Yao, Yin and Yu, Di (2022). Context-dependent regulation of follicular helper T cell survival. Trends in Immunology, 43 (4), 309-321. doi: 10.1016/j.it.2022.02.002

Extrafollicular PD-1highCXCR5–CD4+ T cells participate in local immunoglobulin production in nasal polyps

Wang, Zhi-Chao, Yao, Yin, Chen, Cai-Ling, Guo, Cui-Lian, Ding, Hong-Xia, Song, Jia, Wang, Zhe-Zheng, Wang, Nan, Li, Xue-Li, Liao, Bo, Yang, Yang, Yu, Di and Liu, Zheng (2022). Extrafollicular PD-1highCXCR5–CD4+ T cells participate in local immunoglobulin production in nasal polyps. Journal of Allergy and Clinical Immunology, 149 (2), 610-623. doi: 10.1016/j.jaci.2021.06.023

Evolution of γ chain cytokines: mechanisms, methods and applications

Antczak, Magdalena, Cañete, Pablo F., Chen, Zhian, Belle, Clémence and Yu, Di (2022). Evolution of γ chain cytokines: mechanisms, methods and applications. Computational and Structural Biotechnology Journal, 20, 4746-4755. doi: 10.1016/j.csbj.2022.08.050

Longevity of vaccine protection: immunological mechanism, assessment methods, and improving strategy

Chen, Zhian, Gao, Xin and Yu, Di (2022). Longevity of vaccine protection: immunological mechanism, assessment methods, and improving strategy. View, 3 (1) 20200103, 20200103. doi: 10.1002/viw.20200103

TFH2 cells associate with enhanced humoral immunity to SARS-CoV-2 inactivated vaccine in patients with allergic rhinitis

Yao, Yin, Wang, Zhe-Zheng, Huang, Ao, Liu, Yan, Wang, Nan, Wang, Zhi-Chao, Yang, Lin, Li, Hui-Jun, Xie, Jun-Gang, Zhu, Rong-Fei, Cheng, Li-Ming, Yu, Di and Liu, Zheng (2022). TFH2 cells associate with enhanced humoral immunity to SARS-CoV-2 inactivated vaccine in patients with allergic rhinitis. Clinical and Translational Medicine, 12 (1) e717, e717. doi: 10.1002/ctm2.717

Flow cytometric analysis of T lymphocytes and cytokines in aqueous humor of patients with varicella zoster virus-mediated acute retinal necrosis

Kang, Hao, Wei, Yunbo, Liu, Ming, Yu, Di and Tao, Yong (2021). Flow cytometric analysis of T lymphocytes and cytokines in aqueous humor of patients with varicella zoster virus-mediated acute retinal necrosis. BMC Ophthalmology, 21 (1) 193. doi: 10.1186/s12886-021-01951-1

Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment

Wang, Shuang, Li, Feng, Ye, Tong, Wang, Jianghua, Lyu, Chengliang, Qing, Shuang, Ding, Zhaowen, Gao, Xiaoyong, Jia, Rongrong, Yu, Di, Ren, Jun, Wei, Wei and Ma, Guanghui (2021). Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment. Science Translational Medicine, 13 (615) eabb6981, eabb6981. doi: 10.1126/scitranslmed.abb6981

Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence

Puri, Prianka, Jiang, Simon H., Yang, Yang, Mackay, Fabienne and Yu, Di (2021). Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence. Rheumatology and Autoimmunity, 1 (1), 38-49. doi: 10.1002/rai2.12010

Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus with a potential risk of deteriorating immunopathology

Zhou, Pengcheng, Chen, Jiali, He, Jing, Zheng, Ting, Yunis, Joseph, Makota, Victor, Alexandre, Yannick O., Gong, Fang, Zhang, Xia, Xie, Wuxiang, Li, Yuhui, Shao, Miao, Zhu, Yanshan, Sinclair, Jane E., Miao, Miao, Chen, Yaping, Short, Kirsty R., Mueller, Scott N., Sun, Xiaolin, Yu, Di and Li, Zhanguo (2021). Low-dose IL-2 therapy invigorates CD8+ T cells for viral control in systemic lupus erythematosus with a potential risk of deteriorating immunopathology. PLoS Pathogens, 17 (10) e1009858, e1009858. doi: 10.1371/journal.ppat.1009858

Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis

Yao, Yin, Chen, Zhian, Zhang, Hao, Chen, Cailing, Zeng, Ming, Yunis, Joseph, Wei, Yunbo, Wan, Yanmin, Wang, Naiqi, Zhou, Mingzhe, Qiu, Chao, Zeng, Qunxiong, Ong, Hong Sheng, Wang, Hao, Makota, Fadzai Victor, Yang, Yang, Yang, Zhaohui, Wang, Nan, Deng, Jun, Shen, Chao, Xia, Yan, Yuan, Lin, Lian, Zhaoqin, Deng, Yike, Guo, Cuilian, Huang, Ao, Zhou, Pengcheng, Shi, Haibo, Zhang, Weitian ... Yu, Di (2021). Author Correction: Selenium–GPX4 axis protects follicular helper T cells from ferroptosis. Nature Immunology, 22 (12), 1599-1599. doi: 10.1038/s41590-021-01063-4

Supranutritional selenium suppresses ROS‐induced generation of RANKL‐expressing osteoclastogenic CD4 + T cells and ameliorates rheumatoid arthritis

Qin, Jiahuan, Huang, Xia, Wang, Naiqi, Zhou, Pengcheng, Zhang, Hao, Chen, Zhian, Liang, Kaili, Gong, Dongcheng, Zeng, Qunxiong, Niu, Peng, Chen, Anping, Yuan, Lin, Yang, Zhaohui, Su, Linchong, Shen, Nan, Deng, Jun and Yu, Di (2021). Supranutritional selenium suppresses ROS‐induced generation of RANKL‐expressing osteoclastogenic CD4 + T cells and ameliorates rheumatoid arthritis. Clinical & Translational Immunology, 10 (9) e1338, e1338. doi: 10.1002/cti2.1338

Huangbai liniment ameliorates skin inflammation in atopic dermatitis

Zheng, Ting, Fan, Miao, Wei, Yunbo, Feng, Jinhong, Zhou, Pengcheng, Sun, Xin, Xue, Anqi, Qin, Cheng Xue and Yu, Di (2021). Huangbai liniment ameliorates skin inflammation in atopic dermatitis. Frontiers in Pharmacology, 12 726035, 726035. doi: 10.3389/fphar.2021.726035

Selenium–GPX4 axis protects follicular helper T cells from ferroptosis

Yao, Yin, Chen, Zhian, Zhang, Hao, Chen, Cailing, Zeng, Ming, Yunis, Joseph, Wei, Yunbo, Wan, Yanmin, Wang, Naiqi, Zhou, Mingzhe, Qiu, Chao, Zeng, Qunxiong, Ong, Hong Sheng, Wang, Hao, Makota, Fadzai Victor, Yang, Yang, Yang, Zhaohui, Wang, Nan, Deng, Jun, Shen, Chao, Xia, Yan, Yuan, Lin, Lian, Zhaoqin, Deng, Yike, Guo, Cuilian, Huang, Ao, Zhou, Pengcheng, Shi, Haibo, Zhang, Weitian ... Yu, Di (2021). Selenium–GPX4 axis protects follicular helper T cells from ferroptosis. Nature Immunology, 22 (9), 1127-1139. doi: 10.1038/s41590-021-00996-0

Dimensionality reduction by UMAP reinforces sample heterogeneity analysis in bulk transcriptomic data

Yang, Yang, Sun, Hongjian, Zhang, Yu, Zhang, Tiefu, Gong, Jialei, Wei, Yunbo, Duan, Yong-Gang, Shu, Minglei, Yang, Yuchen, Wu, Di and Yu, Di (2021). Dimensionality reduction by UMAP reinforces sample heterogeneity analysis in bulk transcriptomic data. Cell Reports, 36 (4) 109442, 109442. doi: 10.1016/j.celrep.2021.109442

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

Tian, Ying, Zhang, Fan, Qiu, Yefeng, Wang, Shuang, Li, Feng, Zhao, Jiawei, Pan, Chao, Tao, Yong, Yu, Di and Wei, Wei (2021). Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells. Nature Biomedical Engineering, 5 (9), 968-982. doi: 10.1038/s41551-021-00764-3

CXCR5+CD8+ T cells shape antibody responses in vivo following protein immunisation and peripheral viral infection

Tyllis, Timona S., Fenix, Kevin A., Norton, Todd S., Kara, Ervin E., McKenzie, Duncan R., David, Shannon C., Alsharifi, Mohammed, Yu, Di, McColl, Shaun R. and Comerford, Iain (2021). CXCR5+CD8+ T cells shape antibody responses in vivo following protein immunisation and peripheral viral infection. Frontiers in Immunology, 12 626199, 626199. doi: 10.3389/fimmu.2021.626199

PH and proton sensor GPR65 determine susceptibility to atopic dermatitis

Xie, Liang, McKenzie, Craig I., Qu, Xinyan, Mu, Yan, Wang, Quanbo, Bing, Nan, Naidoo, Karmella, Alam, Md Jahangir, Yu, Di, Gong, Fang, Ang, Caroline, Robert, Remy, Marques, Francine Z., Furlotte, Nicholas, Hinds, David, Gasser, Olivier, Xavier, Ramnik J., MacKay, Charles R., Agee, Michelle, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H. ... 23andMe Research Team (2021). PH and proton sensor GPR65 determine susceptibility to atopic dermatitis. Journal of Immunology, 207 (1), 101-109. doi: 10.4049/jimmunol.2001363

Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus

Liang, Kaili, He, Jing, Wei, Yunbo, Zeng, Qunxiong, Gong, Dongcheng, Qin, Jiahuan, Ding, Huihua, Chen, Zhian, Zhou, Ping, Niu, Peng, Chen, Qian, Ding, Chenguang, Lu, Liangjing, Chen, Xiao-Xiang, Li, Zhanguo, Shen, Nan, Yu, Di and Deng, Jun (2021). Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus. Clinical and Translational Immunology, 10 (6) e1293, e1293. doi: 10.1002/cti2.1293

The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses

Deng, Jun, Chen, Qian, Chen, Zhian, Liang, Kaili, Gao, Xin, Wang, Xiaohui, Makota, Fadzai V., Ong, Hong Sheng, Wan, Yanmin, Luo, Kaiming, Gong, Dongcheng, Yu, Xiang, Camuglia, Sarina, Zeng, Qunxiong, Zhou, Tao, Xue, Feng, He, Jing, Wei, Yunbo, Xiao, Fan, Ma, Jianyang, Hill, Danika L., Pierson, Wim, Nguyen, Thi H. O., Zhou, Haibo, Wang, Yan, Shen, Wei, Sun, Lingyun, Li, Zhanguo, Xia, Qiang ... Yu, Di (2021). The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses. Nature Communications, 12 (1) 3073, 3073. doi: 10.1038/s41467-021-23220-x

Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

Wang, Hai, Hu, Dan-Qing, Xiao, Qiao, Liu, Yi-Bo, Song, Jia, Liang, Yuxia, Ruan, Jian-Wen, Wang, Zhe-Zheng, Li, Jing-Xian, Pan, Li, Wang, Meng-Chen, Zeng, Ming, Shi, Li-Li, Xu, Kai, Ning, Qin, Zhen, Guohua, Yu, Di, Wang, De-Yun, Wenzel, Sally E. and Liu, Zheng (2021). Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology, 147 (5), 1692-1703. doi: 10.1016/j.jaci.2020.12.623

Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older

Tan, Qiyue, Lv, Yuebin, Zhao, Feng, Zhou, Jinhui, Yang, Yang, Liu, Yingchun, Zhang, Mingyuan, Lu, Feng, Wei, Yuan, Chen, Xin, Zhang, Ruizhi, Chen, Chen, Wu, Bing, Zhang, Xiaochang, Li, Chengcheng, Huang, Hongyuan, Cai, Junfang, Cao, Zhaojin, Yu, Di, Ji, John S., Zhao, Shuhua and Shi, Xiaoming (2021). Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older. Science of the Total Environment, 758 143638, 1-8. doi: 10.1016/j.scitotenv.2020.143638

Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy

Yao, Yin, Chen, Cai-Ling, Yu, Di and Liu, Zheng (2021). Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy. Allergy, 76 (2), 456-470. doi: 10.1111/all.14639

High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses

Xie, Min, Yunis, Joseph, Yao, Yin, Shi, Jing, Yang, Yang, Zhou, Pengcheng, Liang, Kaili, Wan, Yanmin, Mehdi, Ahmed, Chen, Zhian, Wang, Naiqi, Xu, Shuyun, Zhou, Min, Yu, Muqing, Wang, Ke, Tao, Yu, Zhou, Ying, Li, Xiaochen, Liu, Xiansheng, Yu, Xiao, Wei, Yunbo, Liu, Zheng, Sprent, Jonathan and Yu, Di (2021). High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses. Clinical & Translational Immunology, 10 (2) e1251, e1251. doi: 10.1002/cti2.1251

T lymphocytes and testicular immunity: a new insight into immune regulation in testes

Gong, Jialei, Zeng, Qunxiong, Yu, Di and Duan, Yong-Gang (2021). T lymphocytes and testicular immunity: a new insight into immune regulation in testes. International Journal of Molecular Sciences, 22 (1) 57, 1-21. doi: 10.3390/ijms22010057

Chlorinated flame-retardant dechlorane 602 potentiates type 2 innate lymphoid cells and exacerbates airway inflammation

Zhou, Pengcheng, Zheng, Ting, Li, Yunping, Zhang, Xin, Feng, Jinhong, Wei, Yunbo, Wang, Hao, Yao, Yin, Gong, Fang, Tian, Wenjing, Sun, Lingyun, Liu, Zheng, Zhao, Bin and Yu, Di (2020). Chlorinated flame-retardant dechlorane 602 potentiates type 2 innate lymphoid cells and exacerbates airway inflammation. Environmental Science and Technology, 55 (2) acs.est.0c03758, 1099-1109. doi: 10.1021/acs.est.0c03758

Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity

Lv, Cui, Zhang, Hao, Li, Zifa, Zhang, Hao, Zhang, Yu, Li, Ronghui, Wei, Sheng and Yu, Di (2020). Low-dose IL-2 therapy compensates for metabolic shifts and reverses anxiety-like behavior in PD-1 deficiency-induced autoimmunity. Cellular and Molecular Immunology, 18 (5), 1336-1338. doi: 10.1038/s41423-020-00562-y

Stereotactic Radiation Therapy Combined With Immunotherapy Against Metastatic Melanoma: Long-Term Results of a Phase 1 Clinical Trial

Ratnayake, Gishan, Reinwald, Simone, Shackleton, Mark, Moore, Maggie, Voskoboynik, Mark, Ruben, Jeremy, van Zelm, Menno C., Yu, Di, Ward, Rachel, Smith, Robin, Haydon, Andrew and Senthi, Sashendra (2020). Stereotactic Radiation Therapy Combined With Immunotherapy Against Metastatic Melanoma: Long-Term Results of a Phase 1 Clinical Trial. International Journal of Radiation Oncology Biology Physics, 108 (1), 150-156. doi: 10.1016/j.ijrobp.2020.05.022

Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals

Gong, Fang, Dai, Yaping, Zheng, Ting, Cheng, Liang, Zhao, Dan, Wang, Hao, Liu, Min, Pei, Hao, Jin, Tengchuan, Yu, Di and Zhou, Pengcheng (2020). Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals. Journal of Clinical Investigation, 130 (12), 6588-6599. doi: 10.1172/jci141054

CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis

Yao, Yin, Wang, Nan, Chen, Cai-Ling, Pan, Li, Wang, Zhi-Chao, Yunis, Joseph, Chen, Zhi-An, Zhang, Yu, Hu, Si-Tao, Xu, Xiao-Yan, Zhu, Rong-Fei, Yu, Di and Liu, Zheng (2020). CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis. Allergy, 75 (10), 1-14. doi: 10.1111/all.14288

Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial

He, Jing, Zhang, Ruijun, Shao, Miao, Zhao, Xiaozhen, Miao, Miao, Chen, Jiali, Liu, Jiajia, Zhang, Xiaoying, Zhang, Xia, Jin, Yuebo, Wang, Yu, Zhang, Shilei, Zhu, Lei, Jacob, Alexander, Jia, Rulin, You, Xujie, Li, Xue, Li, Chun, Zhou, Yunshan, Yang, Yue, Ye, Hua, Liu, Yanying, Su, Yin, Shen, Nan, Alexander, Jessy, Guo, Jianping, Ambrus, Julian, Lin, Xin, Yu, Di ... Li, Zhanguo (2020). Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial. Annals of the Rheumatic Diseases, 79 (1), 141-149. doi: 10.1136/annrheumdis-2019-215396

Follicular helper T cells in type 1 diabetes

Shao, Feng, Zheng, Peilin, Yu, Di, Zhou, Zhiguang and Jia, Lijing (2020). Follicular helper T cells in type 1 diabetes. The FASEB Journal, 34 (1), 30-40. doi: 10.1096/fj.201901637R

Prominent immune signatures of T cells are specifically associated with indolent B-cell lymphoproliferative disorders and predict prognosis

Yi, Shuhua, Zhang, Yu, Xiong, Wenjie, Chen, Weiwei, Hou, Zhaohua, Yang, Yang, Yan, Yuting, Wei, Yunbo, Cui, Rui, Wang, Huijun, Yu, Zhen, Li, Heng, Li, Zengjun, Liu, Wei, Lv, Rui, Wang, Tingyu, Ru, Kun, Zou, Dehui, Shu, Minglei, Qiu, Lugui and Yu, Di (2020). Prominent immune signatures of T cells are specifically associated with indolent B-cell lymphoproliferative disorders and predict prognosis. Clinical and Translational Immunology, 9 (1) e01105. doi: 10.1002/cti2.1105

An optimized method to differentiate mouse follicular helper T cells in vitro

Gao, Xin, Wang, Hao, Chen, Zhian, Zhou, Pengcheng and Yu, Di (2019). An optimized method to differentiate mouse follicular helper T cells in vitro. Cellular and Molecular Immunology, 17 (7), 779-781. doi: 10.1038/s41423-019-0329-7

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Wang, Huimeng, Kjer-Nielsen, Lars, Shi, Mai, D'Souza, Criselle, Pediongco, Troi J., Cao, Hanwei, Kostenko, Lyudmila, Lim, Xin Yi, Eckle, Sidonia B. G., Meehan, Bronwyn S., Zhu, Tianyuan, Wang, Bingjie, Zhao, Zhe, Mak, Jeffrey Y. W., Fairlie, David P., Teng, Michele W. L., Rossjohn, Jamie, Yu, Di, de St Groth, Barbara Fazekas, Lovrecz, George, Lu, Louis, McCluskey, James, Strugnell, Richard A., Corbett, Alexandra J. and Chen, Zhenjun (2019). IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. Science Immunology, 4 (41) eaaw0402, eaaw0402. doi: 10.1126/sciimmunol.aaw0402

Germinal center T-FH cells: T(w)o be or not t(w)o be, IL-6 is the answer

Zhou, Pengcheng, Liang, Kaili and Yu, Di (2019). Germinal center T-FH cells: T(w)o be or not t(w)o be, IL-6 is the answer. Science Immunology, 4 (39) eaay7668, eaay7668. doi: 10.1126/sciimmunol.aay7668

Combined blockade of Smad3 and JNK pathways ameliorates progressive fibrosis in folic acid nephropathy

Jiang, Mengjie, Fan, Jinjin, Qu, Xinli, Li, Songhui, Nilsson, Susan K., Sun, Yu Bo Yang, Chen, Yaping, Yu, Di, Liu, Dan, Liu, Bi-Cheng, Tang, Mingliang, Chen, Wei, Ren, Yi, Nikolic-Paterson, David J., Jiang, Xiaoyun, Li, Jinhua and Yu, Xueqing (2019). Combined blockade of Smad3 and JNK pathways ameliorates progressive fibrosis in folic acid nephropathy. Frontiers in Pharmacology, 10. doi: 10.3389/fphar.2019.00880

T follicular helper cells and T follicular regulatory cells in rheumatic diseases

Deng, Jun, Wei, Yunbo, Fonseca, Valter R., Graca, Luis and Yu, Di (2019). T follicular helper cells and T follicular regulatory cells in rheumatic diseases. Nature Reviews Rheumatology, 15 (8), 475-490. doi: 10.1038/s41584-019-0254-2

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

Yao, Yin, Wang, Zhi-Chao, Wang, Nan, Zhou, Peng-Cheng, Chen, Cai-Ling, Song, Jia, Pan, Li, Liao, Bo, Zhang, Xin-Hao, Yang, Yong-Shi, Xu, Xiao-Yan, Zhu, Rong-Fei, Yu, Di and Liu, Zheng (2019). Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis. Journal of Allergy and Clinical Immunology, 144 (1), 118-128. doi: 10.1016/j.jaci.2019.02.008

T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities

Wiede, Florian, Brodnicki, Thomas C., Goh, Pei Kee, Leong, Yew A., Jones, Gareth W., Yu, Di, Baxter, Alan G., Jones, Simon A., Kay, Thomas W.H. and Tiganis, Tony (2019). T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities. Diabetes, 68 (6), 1251-1266. doi: 10.2337/db18-1362

Role of circulating T follicular helper subsets and T follicular helper effector memory cells in systemic lupus erythematosus 外周血效应型滤泡辅助性T细胞和滤泡辅助性T细胞亚型在系统性红斑狼疮发病机制中的作用

Liang, Yichen, Yao, Yang, Zhang, Ruijun, Shao, Miao, Sun, Xiaolin, Shi, Guixiu, Gao, Chun, Yu, Di and He, Jing (2019). Role of circulating T follicular helper subsets and T follicular helper effector memory cells in systemic lupus erythematosus 外周血效应型滤泡辅助性T细胞和滤泡辅助性T细胞亚型在系统性红斑狼疮发病机制中的作用. National Medical Journal of China, 99 (3), 164-168. doi: 10.3760/cma.j.issn.0376-2491.2019.03.002

Tissue-Specific Immunity in Homeostasis and Diseases

Wu, Ning, Sun, Erwei, Liu, Dongfang and Yu, Di (2019). Tissue-Specific Immunity in Homeostasis and Diseases. Journal of Immunology Research, 2019 7616509, 1-2. doi: 10.1155/2019/7616509

A portrait of CXCR5(+) follicular cytotoxic CD8(+) T cells

Yu, Di and Ye, Lilin (2018). A portrait of CXCR5(+) follicular cytotoxic CD8(+) T cells. Trends in Immunology, 39 (12), 965-979. doi: 10.1016/j.it.2018.10.002

Role of allergen-specific T-follicular helper cells in immunotherapy

Yao, Yin, Wang, Zhi-Chao, Yu, Di and Liu, Zheng (2018). Role of allergen-specific T-follicular helper cells in immunotherapy. Current Opinion in Allergy and Clinical Immunology, 18 (6), 495-501. doi: 10.1097/aci.0000000000000480

Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy

Yao, Yin, Chen, Cai-Ling, Wang, Nan, Wang, Zhi-Chao, Ma, Jin, Zhu, Rong-Fei, Xu, Xiao-Yan, Zhou, Peng-Cheng, Yu, Di and Liu, Zheng (2018). Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy. Journal of Allergy and Clinical Immunology, 142 (1), 321-324. doi: 10.1016/j.jaci.2018.03.008

Signal transducer and activator of transcription 3 hyperactivation associates with follicular helper T cell differentiation and disease activity in rheumatoid arthritis

Deng, Jun, Fan, Chaofan, Gao, Xin, Zeng, Qunxiong, Guo, Ruru, Wei, Yunbo, Chen, Zhian, Chen, Yanan, Gong, Dongcheng, Feng, Jia, Xia, Yan, Xiang, Shifei, Gong, Shushi, Yuan, Lin, Shen, Wei, Shen, Wenyan, Lin, Lin, Jiang, Ting, He, Dongyi, Lu, Liangjing, Chen, Xiaoxiang and Yu, Di (2018). Signal transducer and activator of transcription 3 hyperactivation associates with follicular helper T cell differentiation and disease activity in rheumatoid arthritis. Frontiers in Immunology, 9 (JUN) 1226, 1-11. doi: 10.3389/fimmu.2018.01226

Ectopic lymphoid tissues support local immunoglobulin production in patients with chronic rhinosinusitis with nasal polyps

Song, Jia, Wang, Hai, Zhang, Ya-Na, Cao, Ping-Ping, Liao, Bo, Wang, Zhe-Zheng, Shi, Li-Li, Yao, Yin, Zhai, Guan-Ting, Wang, Zhi-Chao, Liu, Li-Meng, Zeng, Ming, Lu, Xiang, Wang, Heng, Yang, Xiang-Ping, Yu, Di, Bachert, Claus and Liu, Zheng (2018). Ectopic lymphoid tissues support local immunoglobulin production in patients with chronic rhinosinusitis with nasal polyps. Journal of Allergy and Clinical Immunology, 141 (3), 927-937. doi: 10.1016/j.jaci.2017.10.014

Potentiating tissue-resident type 2 innate lymphoid cells by IL-33 to prevent renal ischemia-reperfusion injury

Cao, Qi, Wang, Yiping, Niu, Zhiguo, Wang, Chengshi, Wang, Ruifeng, Zhang, Zhiqiang, Chen, Titi, Wang, Xin Maggie, Li, Qing, Lee, Vincent W. S., Huang, Qingsong, Tan, Jing, Guo, Minghao, Wang, Yuan Min, Zheng, Guoping, Yu, Di, Alexander, Stephen I., Wang, Hui and Harris, David C. H. (2018). Potentiating tissue-resident type 2 innate lymphoid cells by IL-33 to prevent renal ischemia-reperfusion injury. Journal of the American Society of Nephrology, 29 (3), 961-976. doi: 10.1681/ASN.2017070774

Site-mutation of hydrophobic core residues synchronically poise super interleukin 2 for signaling: identifying distant structural effects through affordable computations

Mei, Longcan, Zhou, Yanping, Zhu, Lizhe, Liu, Changlin, Wu, Zhuo, Wang, Fangkui, Hao, Gefei, Yu, Di, Yuan, Hong and Cui, Yanfang (2018). Site-mutation of hydrophobic core residues synchronically poise super interleukin 2 for signaling: identifying distant structural effects through affordable computations. International Journal of Molecular Sciences, 19 (3) 916, 916. doi: 10.3390/ijms19030916

Serum metabolic profile alteration reveals response to platinum-based combination chemotherapy for lung cancer: sensitive patients distinguished from insensitive ones

Xu, Shan, Zhou, Yanping, Geng, Hui, Song, Dandan, Tang, Jing, Zhu, Xianmin, Yu, Di, Hu, Sheng and Cui, Yanfang (2017). Serum metabolic profile alteration reveals response to platinum-based combination chemotherapy for lung cancer: sensitive patients distinguished from insensitive ones. Scientific Reports, 7 (1) 17524. doi: 10.1038/s41598-017-16085-y

Biomimetically engineered demi-bacteria potentiate vaccination against cancer

Ni, Dezhi, Qing, Shuang, Ding, Hui, Yue, Hua, Yu, Di, Wang, Shuang, Luo, Nana, Su, Zhiguo, Wei, Wei and Ma, Guanghui (2017). Biomimetically engineered demi-bacteria potentiate vaccination against cancer. Advanced Science, 4 (10), 1700083. doi: 10.1002/advs.201700083

The rise of IL-2 therapy - a picture beyond T-reg cells

Li, Zhanguo, He, Jing and Yu, Di (2017). The rise of IL-2 therapy - a picture beyond T-reg cells. Nature Reviews. Rheumatology, 13 (6), 386-386. doi: 10.1038/nrrheum.2017.70

Human immunodeficiency virus Playing Hide-and-Seek: Understanding the T-FH Cell Reservoir and Proposing Strategies to Overcome the Follicle Sanctuary

Leong, Yew Ann, Atnerkar, Anurag and Yu, Di (2017). Human immunodeficiency virus Playing Hide-and-Seek: Understanding the T-FH Cell Reservoir and Proposing Strategies to Overcome the Follicle Sanctuary. Frontiers in Immunology, 8 (MAY) 622. doi: 10.3389/fimmu.2017.00622

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

Wiede, Florian, Sacirbegovic, Faruk, Leong, Yew Ann, Yu, Di and Tiganis, Tony (2017). PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity. Journal of Autoimmunity, 76, 85-100. doi: 10.1016/j.jaut.2016.09.004

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

Leong, Yew Ann, Chen, Yaping, Ong, Hong Sheng, Wu, Di, Man, Kevin, Deleage, Claire, Minnich, Martina, Meckiff, Benjamin J., Wei, Yunbo, Hou, Zhaohua, Zotos, Dimitra, Fenix, Kevin A., Atnerkar, Anurag, Preston, Simon, Chipman, Jeffrey G., Beilman, Greg J., Allison, Cody C., Sun, Lei, Wang, Peng, Xu, Jiawei, Toe, Jesse G., Lu, Hao K., Tao, Yong, Palendira, Umaimainthan, Dent, Alexander L., Landay, Alan L., Pellegrini, Marc, Comerford, Iain, McColl, Shaun R. ... Yu, Di (2016). CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles. Nature Immunology, 17 (10), 1187-+. doi: 10.1038/ni.3543

Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus

He, Jing, Zhang, Xia, Wei, Yunbo, Sun, Xiaolin, Chen, Yaping, Deng, Jun, Jin, Yuebo, Gan, Yuzhou, Hu, Xin, Jia, Rulin, Xu, Chuanhui, Hou, Zhaohua, Leong, Yew Ann, Zhu, Lei, Feng, Jinhong, An, Yuan, Jia, Yuan, Li, Chun, Liu, Xu, Ye, Hua, Ren, Limin, Li, Ru, Yao, Haihong, Li, Yuhui, Chen, Shi, Zhang, Xuewu, Su, Yin, Guo, Jianping, Shen, Nan ... Li, Zhanguo (2016). Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus. Nature Medicine, 22 (9), 991-993. doi: 10.1038/nm.4148

The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice

Chevalier, Nina, Macia, Laurence, Tan, Jian K., Mason, Linda J., Robert, Remy, Thorburn, Alison N., Wong, Connie H. Y., Tsai, Louis M., Bourne, Katherine, Brink, Robert, Yu, Di and Mackay, Charles R. (2016). The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice. Arthritis and Rheumatology, 68 (4), 1026-1038. doi: 10.1002/art.39481

Severe malaria infections impair germinal center responses by inhibiting T follicular helper cell differentiation

Ryg-Cornejo, Victoria, Ioannidis, Lisa Julia, Ly, Ann, Chiu, Chris Yu, Tellier, Julie, Hill, Danika Lea, Preston, Simon Peter, Pellegrini, Marc, Yu, Di, Nutt, Stephen Laurence, Kallies, Axel and Hansen, Diana Silvia (2016). Severe malaria infections impair germinal center responses by inhibiting T follicular helper cell differentiation. Cell Reports, 14 (1), 68-81. doi: 10.1016/j.celrep.2015.12.006

Follicular helper T cells

Vinuesa, Carola G., Linterman, Michelle A., Yu, Di and MacLennan, Ian C. M. (2016). Follicular helper T cells. Annual Review of Immunology, 34 (1), 335-368. doi: 10.1146/annurev-immunol-041015-055605

TCF-1 at the Tfh and Th1 Divergence

Chen, Yaping and Yu, Di (2015). TCF-1 at the Tfh and Th1 Divergence. Trends in Immunology, 36 (12), 758-760. doi: 10.1016/j.it.2015.11.001

Control of lymphocyte homeostasis and effector function by the aryl hydrocarbon receptor

Wang, Hao, Wei, Yunbo and Yu, Di (2015). Control of lymphocyte homeostasis and effector function by the aryl hydrocarbon receptor. International Immunopharmacology, 28 (2), 818-824. doi: 10.1016/j.intimp.2015.03.046

A pathogenetic role for IL-21 in primary Sjogren syndrome

Kwok, Seung-Ki, Lee, Jennifer, Yu, Di, Kang, Kwi Young, Cho, Mi-La, Kim, Hae-Rim, Ju, Ji Hyeon, Lee, Sang-Heon, Park, Sung-Hwan and Kim, Ho-Youn (2015). A pathogenetic role for IL-21 in primary Sjogren syndrome. Nature Reviews Rheumatology, 11 (6), 368-374. doi: 10.1038/nrrheum.2014.225

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion

Cheyalier, Nina, Thorburn, Alison N., Macia, Laurence, Tan, Jian, Juglair, Laurent, Yagita, Hideo, Yu, Di, Hansbro, Philip M. and Mackay, Charles R. (2014). Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion. Journal of Immunology, 193 (10), 4845-4858. doi: 10.4049/jimmunol.1302966

MicroRNAs in Tfh Cells: Micromanaging Inflammaging

Yu, Di (2014). MicroRNAs in Tfh Cells: Micromanaging Inflammaging. Immunity, 41 (4), 509-+. doi: 10.1016/j.immuni.2014.10.003

Navigating double negatives: new pathways for regulating TFH differentiation

Yu, Di, Chen, Yaping and Leong, Yew Ann (2014). Navigating double negatives: new pathways for regulating TFH differentiation. Nature Immunology, 15 (7), 597-599. doi: 10.1038/ni.2922

Increased glucose metabolic activity is associated with CD4+ R T-cell activation and depletion during chronic HIV infection

Palmer, Clovis S., Ostrowski, Matias, Gouillou, Maelenn, Tsai, Louis, Yu, Di, Zhou, Jingling, Henstridge, Darren C., Maisa, Anna, Hearps, Anna C., Lewin, Sharon R., Landay, Alan, Jaworowski, Anthony, McCune, Joseph M. and Crowe, Suzanne M. (2014). Increased glucose metabolic activity is associated with CD4+ R T-cell activation and depletion during chronic HIV infection. AIDS, 28 (3), 297-309. doi: 10.1097/QAD.0000000000000128

Follicular helper T-cell memory: establishing new frontiers during antibody response

Tsai, Louis M. and Yu, Di (2014). Follicular helper T-cell memory: establishing new frontiers during antibody response. Immunology and Cell Biology, 92 (1), 57-63. doi: 10.1038/icb.2013.68

The temporospatial control of Tfh cells

Yu, Di and Linterman, Michelle (2014). The temporospatial control of Tfh cells. Immunology and Cell Biology, 92 (1), 20-21. doi: 10.1038/icb.2013.86

Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure

He, Jing, Tsai, Louis M., Leong, Yew Ann, Hu, Xin, Ma, Cindy S., Chevalier, Nina, Sun, Xiaolin, Vandenberg, Kirsten, Rockman, Steve, Ding, Yan, Zhu, Lei, Wei, Wei, Wang, Changqi, Karnowski, Alexander, Belz, Gabrielle T., Ghali, Joanna R., Cook, Matthew C., Riminton, D. Sean, Veillette, Andre, Schwartzberg, Pamela L., Mackay, Fabienne, Brink, Robert, Tangye, Stuart G., Vinuesa, Carola G., Mackay, Charles R., Li, Zhanguo and Yu, Di (2013). Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity, 39 (4), 770-781. doi: 10.1016/j.immuni.2013.09.007

Efficient production of recombinant IL-21 proteins for pre-clinical studies by a two-step dilution refolding method

Chen, Zhian, Cui, Yanfang, Leong, Yew Ann, Beddoe, Travis and Yu, Di (2013). Efficient production of recombinant IL-21 proteins for pre-clinical studies by a two-step dilution refolding method. International Immunopharmacology, 16 (3), 376-381. doi: 10.1016/j.intimp.2013.02.017

Characteristics of Sjogren's syndrome in rheumatoid arthritis

He, Jing, Ding, Yan, Feng, Min, Guo, Jianping, Sun, Xiaolin, Zhao, Jing, Yu, Di and Li, Zhanguo (2013). Characteristics of Sjogren's syndrome in rheumatoid arthritis. Rheumatology, 52 (6), 1084-1089. doi: 10.1093/rheumatology/kes374

Roquin-2 shares functions with its paralog roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation

Pratama, Alvin, Ramiscal, Roybel R., Silva, Diego G., Das, Souvik K., Athanasopoulos, Vicki, Fitch, Jessica, Botelho, Natalia K., Chang, Pheh-Ping, Hu, Xin, Hogan, Jennifer J., Mana, Paula, Bernal, David, Korner, Heinrich, Yu, Di, Goodnow, Christopher C., Cook, Matthew C. and Vinuesa, Carola G. (2013). Roquin-2 shares functions with its paralog roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity, 38 (4), 669-680. doi: 10.1016/j.immuni.2013.01.011

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

Lee, Sau K., Rigby, Robert J., Zotos, Dimitra, Tsai, Louis M., Kawamoto, Shimpei, Marshall, Jennifer L., Ramiscal, Roybel R., Chan, Tyani D., Gatto, Dominique, Brink, Robert, Yu, Di, Fagarasan, Sidonia, Tarlinton, David M., Cunningham, Adam F. and Vinuesa, Carola G. (2011). B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. Journal of Experimental Medicine, 208 (7), 1377-1388. doi: 10.1084/jem.20102065

IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease

Cao, Qi, Wang, Changqi, Zheng, Dong, Wang, Ya, Lee, Vincent W. S., Wang, Yuan Min, Zheng, Guoping, Tan, Thian Kui, Yu, Di, Alexander, Stephen I., Harris, David C. H. and Wang, Yiping (2011). IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease. Journal of the American Society of Nephrology, 22 (7), 1229-1239. doi: 10.1681/ASN.2010070693

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chevalier, Nina, Jarrossay, David, Ho, Edwin, Avery, Danielle T., Ma, Cindy S., Yu, Di, Sallusto, Federica, Tangye, Stuart G. and Mackay, Charles R. (2011). CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. Journal of Immunology, 186 (10), 5556-5568. doi: 10.4049/jimmunol.1002828

Heparanase in primary human osteoblasts

Smith, Paul N., Freeman, Craig, Yu, Di, Chen, Mingming, Gatenby, Paul A., Parish, Christopher R. and Li, Rachel W. (2010). Heparanase in primary human osteoblasts. Journal of Orthopaedic Research, 28 (10), 1315-1322. doi: 10.1002/jor.21138

The elusive identity of T follicular helper cells

Yu, Di and Vinuesa, Carola G. (2010). The elusive identity of T follicular helper cells. Trends in Immunology, 31 (10), 377-383. doi: 10.1016/j.it.2010.07.001

Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

Yu, Di and Vinuesa, Carola G. (2010). Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity. Cellular and Molecular Immunology, 7 (3), 198-203. doi: 10.1038/cmi.2010.18

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

Athanasopoulos, Vicki, Barker, Andrew, Yu, Di, Tan, Andy H-M., Srivastava, Monika, Contreras, Nelida, Wang, Jianbin, Lam, Kong-Peng, Brown, Simon H. J., Goodnow, Christopher C., Dixon, Nicholas E., Leedman, Peter J., Saint, Robert and Vinuesa, Carola G. (2010). The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. Febs Journal, 277 (9), 2109-2127. doi: 10.1111/j.1742-4658.2010.07628.x

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Linterman, Michelle A., Beaton, Laura, Yu, Di, Ramiscal, Roybel R., Srivastava, Monika, Hogan, Jennifer J., Verma, Naresh K., Smyth, Mark J., Rigby, Robert J. and Vinuesa, Carola G. (2010). IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. Journal of Experimental Medicine, 207 (2), 353-363. doi: 10.1084/jem.20091738

Evidence for microRNA-mediated regulation in rheumatic diseases

Luo, X., Tsai, L. M., Shen, N. and Yu, D. (2010). Evidence for microRNA-mediated regulation in rheumatic diseases. Annals of the Rheumatic Diseases, 69 (Suppl 1), 30-36. doi: 10.1136/ard.2009.117218

MicroRNAs in common diseases and potential therapeutic applications

Tsai, Louis M. and Yu, Di (2010). MicroRNAs in common diseases and potential therapeutic applications. Clinical and Experimental Pharmacology and Physiology, 37 (1), 102-107. doi: 10.1111/j.1440-1681.2009.05269.x

Lineage specification and heterogeneity of T follicular helper cells

Yu, Di, Batten, Marcel, Mackay, Charles R. and King, Cecile (2009). Lineage specification and heterogeneity of T follicular helper cells. Current Opinion in Immunology, 21 (6), 619-625. doi: 10.1016/j.coi.2009.09.013

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, Kendle M., Vieira, Angelica T., Ng, Aylwin, Kranich, Jan, Sierro, Frederic, Yu, Di, Schilter, Heidi C., Rolph, Michael S., Mackay, Fabienne, Artis, David, Xavier, Ramnik J., Teixeira, Mauro M. and Mackay, Charles R. (2009). Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 461 (7268), 1282-1286. doi: 10.1038/nature08530

The transcriptional repressor Bcl-6 directs t follicular helper cell lineage commitment

Yu, Di, Rao, Sudha, Tsai, Louis M., Lee, Sau K., He, Yiqing, Sutcliffe, Elissa L., Srivastava, Monika, Linterman, Michelle, Zheng, Lei, Simpson, Nicholas, Ellyard, Julia I., Parish, Ian A., Ma, Cindy S., Li, Qi-Jing, Parish, Christopher R., Mackay, Charles R. and Vinuesa, Carola G. (2009). The transcriptional repressor Bcl-6 directs t follicular helper cell lineage commitment. Immunity, 31 (3), 457-468. doi: 10.1016/j.immuni.2009.07.002

Follicular helper T cells are required for systemic autoimmunity

Linterman, Michelle A., Rigby, Robert J., Wong, Raphael. K., Yu, Di, Brink, Robert, Cannons, Jennifer L., Schwartzberg, Pamela L., Cook, Matthew C., Walters, Giles D. and Vinuesa, Carola G. (2009). Follicular helper T cells are required for systemic autoimmunity. Journal of Experimental Medicine, 206 (3), 561-576. doi: 10.1084/jem.20081886

Logic and extent of miRNA-mediated control of autoimmune gene expression

Vinuesa, Carola G., Rigby, Robert J. and Yu, Di (2009). Logic and extent of miRNA-mediated control of autoimmune gene expression. International Reviews of Immunology, 28 (3-4), 112-138. doi: 10.1080/08830180902934909

Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL

Wu, Zuopeng, Jia, Xinying, de la Cruz, Laura, Su, Xun-Cheng, Marzolf, Bruz, Troisch, Pamela, Zak, Daniel, Hamilton, Adam, Whittle, Belinda, Yu, Di, Sheahan, Daniel, Bertram, Edward, Aderem, Alan, Otting, Gottfried, Goodnow, Christopher C. and Hoyne, Gerard F. (2008). Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity, 29 (6), 863-875. doi: 10.1016/j.immuni.2008.11.004

Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei, Wei, Ma, Guang-Hui, Hu, Gang, Yu, Di, Mcleish, Tom, Su, Zhi-Guo and Shen, Zhe-Yu (2008). Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier. Journal of the American Chemical Society, 130 (47), 15808-15810. doi: 10.1021/ja8039585

A fundamental role for interleukin-21 in the generation of T follicular helper cells

Vogelzang, Alexis, McGuire, Helen M., Yu, Di, Sprent, Jonathan, Mackay, Charles R. and King, Cecile (2008). A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity, 29 (1), 127-137. doi: 10.1016/j.immuni.2008.06.001

Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis

Li, Rachel W., Freeman, Craig, Yu, Di, Hindmarsh, Elizabeth J., Tymms, Kathleen E., Parish, Christopher R. and Smith, Paul N. (2008). Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis. Arthritis and Rheumatism, 58 (6), 1590-1600. doi: 10.1002/art.23489

Axon growth and guidance genes identify T-dependent germinal centre B cells

Yu, Di, Cook, Matthew C., Shin, Dong-Mi, Silva, Diego G., Marshall, Jennifer, Toellner, Kai-Michael, Havran, Wendy L., Caroni, Pico, Cooke, Michael P., Morse, Herbert C., MacLennan, Ian C. M., Goodnow, Christopher C. and Vinuesa, Carola G. (2008). Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunology and Cell Biology, 86 (1), 3-14. doi: 10.1038/sj.icb.7100123

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Yu, Di, Tan, Andy Hee-Meng, Hu, Xin, Athanasopoulos, Vicki, Simpson, Nicholas, Silva, Diego G., Hutloff, Andreas, Giles, Keith M., Leedman, Peter J., Lam, Kong Peng, Goodnow, Christopher C. and Vinuesa, Carola G. (2007). Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature, 450 (7167), 299-U15. doi: 10.1038/nature06253

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

Vinuesa, Carola G., Cook, Matthew C., Angelucci, Constanza, Athanasopoulos, Vicki, Rui, Lixin, Hill, Kim M., Yu, Di, Domaschenz, Heather, Whittle, Belinda, Lambe, Teresa, Roberts, Ian S., Copley, Richard R., Bell, John I., Cornall, Richard J. and Goodnow, Christopher C. (2005). A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature, 435 (7041), 452-458. doi: 10.1038/nature03555