Dr Christian Nefzger

Senior Research Fellow - GL

Institute for Molecular Bioscience
c.nefzger@imb.uq.edu.au
+61 7 334 62053

Overview

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Research Impacts

Kindly visit my laboratory's webpage for more information

Qualifications

  • Doctor of Philosophy, Monash University

Publications

  • Buckberry, Sam, Liu, Xiaodong, Poppe, Daniel, Tan, Jia Ping, Sun, Guizhi, Chen, Joseph, Nguyen, Trung Viet, de Mendoza, Alex, Pflueger, Jahnvi, Frazer, Thomas, Vargas-Landín, Dulce B., Paynter, Jacob M., Smits, Nathan, Liu, Ning, Ouyang, John F., Rossello, Fernando J., Chy, Hun S., Rackham, Owen J. L., Laslett, Andrew L., Breen, James, Faulkner, Geoffrey J., Nefzger, Christian M., Polo, Jose M. and Lister, Ryan (2023). Transient naive reprogramming corrects hiPS cells functionally and epigenetically. Nature, 620 (7975), 863-872. doi: 10.1038/s41586-023-06424-7

  • Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

  • Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa and Nilsson, Susan K. (2023). High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production. Nature Communications, 14 (1) 2099, 1-18. doi: 10.1038/s41467-023-37780-7

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

Journal Article

  • Buckberry, Sam, Liu, Xiaodong, Poppe, Daniel, Tan, Jia Ping, Sun, Guizhi, Chen, Joseph, Nguyen, Trung Viet, de Mendoza, Alex, Pflueger, Jahnvi, Frazer, Thomas, Vargas-Landín, Dulce B., Paynter, Jacob M., Smits, Nathan, Liu, Ning, Ouyang, John F., Rossello, Fernando J., Chy, Hun S., Rackham, Owen J. L., Laslett, Andrew L., Breen, James, Faulkner, Geoffrey J., Nefzger, Christian M., Polo, Jose M. and Lister, Ryan (2023). Transient naive reprogramming corrects hiPS cells functionally and epigenetically. Nature, 620 (7975), 863-872. doi: 10.1038/s41586-023-06424-7

  • Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

  • Heazlewood, Shen Y., Ahmad, Tanveer, Cao, Benjamin, Cao, Huimin, Domingues, Melanie, Sun, Xuan, Heazlewood, Chad K., Li, Songhui, Williams, Brenda, Fulton, Madeline, White, Jacinta F., Nebl, Tom, Nefzger, Christian M., Polo, Jose M., Kile, Benjamin T., Kraus, Felix, Ryan, Michael T., Sun, Yu B., Choong, Peter F. M., Ellis, Sarah L., Anko, Minna-Liisa and Nilsson, Susan K. (2023). High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production. Nature Communications, 14 (1) 2099, 1-18. doi: 10.1038/s41467-023-37780-7

  • Gerdes, Patricia, Lim, Sue Mei, Ewing, Adam D., Larcombe, Michael R., Chan, Dorothy, Sanchez-Luque, Francisco J., Walker, Lucinda, Carleton, Alexander L., James, Cini, Knaupp, Anja S., Carreira, Patricia E., Nefzger, Christian M., Lister, Ryan, Richardson, Sandra R., Polo, Jose M. and Faulkner, Geoffrey J. (2022). Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nature Communications, 13 (1) 7470, 1-18. doi: 10.1038/s41467-022-35180-x

  • Mizikovsky, Dalia, Naval Sanchez, Marina, Nefzger, Christian M, Cuellar Partida, Gabriel and Palpant, Nathan J (2022). Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations. Nucleic Acids Research, 50 (15) e87, 1-12. doi: 10.1093/nar/gkac413

  • Naval-Sanchez, Marina, Deshpande, Nikita, Tran, Minh, Zhang, Jingyu, Alhomrani, Majid, Alsanie, Walaa, Nguyen, Quan and Nefzger, Christian M. (2022). Benchmarking of ATAC Sequencing Data From BGI’s Low-Cost DNBSEQ-G400 Instrument for Identification of Open and Occupied Chromatin Regions. Frontiers in Molecular Biosciences, 9 900323, 1-15. doi: 10.3389/fmolb.2022.900323

  • Nefzger, Christian M., Jardé, Thierry, Srivastava, Akanksha, Schroeder, Jan, Rossello, Fernando J., Horvay, Katja, Prasko, Mirsada, Paynter, Jacob M., Chen, Joseph, Weng, Chen-Fang, Sun, Yu B. Y., Liu, Xiaodong, Chan, Eva, Deshpande, Nikita, Chen, Xiaoli, Li, Y. Jinhua, Pflueger, Jahnvi, Engel, Rebekah M., Knaupp, Anja S., Tsyganov, Kirill, Nilsson, Susan K., Lister, Ryan, Rackham, Owen J. L., Abud, Helen E. and Polo, Jose M. (2022). Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential. npj Regenerative Medicine, 7 (1) 31, 1-8. doi: 10.1038/s41536-022-00226-7

  • Sinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P. and Palpant, Nathan J. (2022). Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation. Cell Reports, 39 (7) 110818, 1-21. doi: 10.1016/j.celrep.2022.110818

  • Keniry, Andrew, Jansz, Natasha, Gearing, Linden J., Wanigasuriya, Iromi, Chen, Joseph, Nefzger, Christian M., Hickey, Peter F., Gouil, Quentin, Liu, Joy, Breslin, Kelsey A., Iminitoff, Megan, Beck, Tamara, Tapia del Fierro, Andres, Whitehead, Lachlan, Jarratt, Andrew, Kinkel, Sarah A., Taberlay, Phillippa C., Willson, Tracy, Pakusch, Miha, Ritchie, Matthew E., Hilton, Douglas J., Polo, Jose M. and Blewitt, Marnie E. (2022). BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation. Nature Communications, 13 (1) 1658, 1658. doi: 10.1038/s41467-022-29333-1

  • Nicholls, Jemma, Cao, Benjamin, Le Texier, Laetitia, Xiong, Laura Yan, Hunter, Christopher R., Llanes, Genesis, Aguliar, Ethan G., Schroder, Wayne A., Phipps, Simon, Lynch, Jason P., Cao, Huimin, Heazlewood, Shen Y., Williams, Brenda, Clouston, Andrew D., Nefzger, Christian M., Polo, Jose M., Nilsson, Susan K., Blazar, Bruce R. and MacDonald, Kelli P. A. (2021). Bone marrow regulatory T cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-versus-host disease control. Frontiers in Cell and Developmental Biology, 9 737880, 737880. doi: 10.3389/fcell.2021.737880

  • Wang, Jueqiong, Farkas, Carlos, Benyoucef, Aissa, Carmichael, Catherine, Haigh, Katharina, Wong, Nick, Huylebroeck, Danny, Stemmler, Marc P., Brabletz, Simone, Brabletz, Thomas, Nefzger, Christian M., Goossens, Steven, Berx, Geert, Polo, Jose M. and Haigh, Jody J. (2021). Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. PLoS Biology, 19 (9) e3001394, 1-33. doi: 10.1371/journal.pbio.3001394

  • Sun, Xuan, Cao, Benjamin, Naval-Sanchez, Marina, Pham, Tony, Sun, Yu Bo Yang, Williams, Brenda, Heazlewood, Shen Y, Deshpande, Nikita, Li, Jinhua, Kraus, Felix, Rae, James, Nguyen, Quan, Yari, Hamed, Schröder, Jan, Heazlewood, Chad K, Fulton, Madeline, Hatwell-Humble, Jessica, Das Gupta, Kaustav, Kapetanovic, Ronan, Chen, Xiaoli, Sweet, Matthew J, Parton, Robert G, Ryan, Michael T, Polo, Jose M, Nefzger, Christian M and Nilsson, Susan K (2021). Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nature Communications, 12 (1) 2665, 1-17. doi: 10.1038/s41467-021-22863-0

  • Jardé, Thierry, Chan, Wing Hei, Rossello, Fernando J., Kaur Kahlon, Tanvir, Theocharous, Mandy, Kurian Arackal, Teni, Flores, Tracey, Giraud, Mégane, Richards, Elizabeth, Chan, Eva, Kerr, Genevieve, Engel, Rebekah M., Prasko, Mirsada, Donoghue, Jacqueline F., Abe, Shin-ichi, Phesse, Toby J., Nefzger, Christian M., McMurrick, Paul J., Powell, David R., Daly, Roger J., Polo, Jose M. and Abud, Helen E. (2020). Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium. Cell Stem Cell, 27 (4), 646-662.e7. doi: 10.1016/j.stem.2020.06.021

  • Liu, Xiaodong, Ouyang, John F., Rossello, Fernando J., Tan, Jia Ping, Davidson, Kathryn C., Valdes, Daniela S., Schröder, Jan, Sun, Yu B. Y., Chen, Joseph, Knaupp, Anja S., Sun, Guizhi, Chy, Hun S., Huang, Ziyi, Pflueger, Jahnvi, Firas, Jaber, Tano, Vincent, Buckberry, Sam, Paynter, Jacob M., Larcombe, Michael R., Poppe, Daniel, Choo, Xin Yi, O’Brien, Carmel M., Pastor, William A., Chen, Di, Leichter, Anna L., Naeem, Haroon, Tripathi, Pratibha, Das, Partha P., Grubman, Alexandra ... Polo, Jose M. (2020). Reprogramming roadmap reveals route to human induced trophoblast stem cells. Nature, 586 (7827), 101-107. doi: 10.1038/s41586-020-2734-6

  • Roco, Jonathan A., Mesin, Luka, Binder, Sebastian C., Nefzger, Christian, Gonzalez-Figueroa, Paula, Canete, Pablo F., Ellyard, Julia, Shen, Qian, Robert, Philippe A., Cappello, Jean, Vohra, Harpreet, Zhang, Yang, Nowosad, Carla R., Schiepers, Arien, Corcoran, Lynn M., Toellner, Kai-Michael, Polo, Jose M., Meyer-Hermann, Michael, Victora, Gabriel D. and Vinuesa, Carola G. (2019). Class-switch recombination occurs infrequently in germinal centers. Immunity, 51 (2), 337-350.e7. doi: 10.1016/j.immuni.2019.07.001

  • Seruggia, Davide, Oti, Martin, Tripathi, Pratibha, Canver, Matthew C., LeBlanc, Lucy, Di Giammartino, Dafne C., Bullen, Michael J., Nefzger, Christian M., Sun, Yu Bo Yang, Farouni, Rick, Polo, Jose M., Pinello, Luca, Apostolou, Effie, Kim, Jonghwan, Orkin, Stuart H. and Das, Partha Pratim (2019). TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network. Molecular Cell, 74 (6), 1148-+. doi: 10.1016/j.molcel.2019.03.025

  • Liu, Xiaodong, Chen, Joseph, Firas, Jaber, Paynter, Jacob M., Nefzger, Christian M. and Polo, Jose M. (2019). Generation of mouse-induced pluripotent stem cells by lentiviral transduction. Methods in Molecular Biology, 1940, 63-76. doi: 10.1007/978-1-4939-9086-3_5

  • Paynter, Jacob M., Chen, Joseph, Liu, Xiaodong and Nefzger, Christian M. (2019). Propagation and maintenance of mouse embryonic stem cells. Methods in Molecular Biology, 1940, 33-45. doi: 10.1007/978-1-4939-9086-3_3

  • Tong, Janette, Lee, Kyung Min, Liu, Xiaodong, Nefzger, Christian M., Vijayakumar, Prasidhee, Hawi, Ziarih, Pang, Ken C., Parish, Clare L., Polo, Jose M. and Bellgrove, Mark A. (2019). Generation of four iPSC lines from peripheral blood mononuclear cells (PBMCs) of an attention deficit hyperactivity disorder (ADHD) individual and a healthy sibling in an Australia-Caucasian family. Stem Cell Research, 34 101353. doi: 10.1016/j.scr.2018.11.014

  • Pflueger, Christian, Tan, Dennis, Swain, Tessa, Trung Nguyen,, Pflueger, Jahnvi, Nefzger, Christian, Polo, Jose M., Ford, Ethan and Lister, Ryan (2018). A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs. Genome Research, 28 (8), 1193-1206. doi: 10.1101/gr.233049.117

  • La, Hue M., Makela, Juho-Antti, Chan, Ai-Leen, Rossello, Fernando J., Nefzger, Christian M., Legrand, Julien M. D., De Seram, Mia, Polo, Jose M. and Hobbs, Robin M. (2018). Identification of dynamic undifferentiated cell states within the male germline. Nature Communications, 9 (1) 2819. doi: 10.1038/s41467-018-04827-z

  • Chen, Joseph, Nefzger, Christian M., Rossello, Fernando J., Sun, Yu B. Y., Lim, Sue Mei, Liu, Xiaodong, de Boer, Suzan, Knaupp, Anja S., Li, Jinhua, Davidson, Kathryn C., Polo, Jose M. and Barberi, Tiziano (2018). Fine tuning of canonical Wnt stimulation enhances differentiation of pluripotent stem cells independent of beta-catenin-mediated T-cell factor signaling. Stem Cells, 36 (6), 822-833. doi: 10.1002/stem.2794

  • Ratnadiwakara, Madara, Archer, Stuart K., Dent, Craig I., De Los Mozos, Igor Ruiz, Beilharz, Traude H., Knaupp, Anja S., Nefzger, Christian M., Polo, Jose M. and Anko, Minna-Liisa (2018). SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program. Elife, 7. doi: 10.7554/eLife.37419

  • Gazina, Elena V., Morrisroe, Emma, Mendis, Gunarathna D. C., Michalska, Anna E., Chen, Joseph, Nefzger, Christian M., Rollo, Benjamin N., Reid, Christopher A., Pera, Martin F. and Petrou, Steven (2018). Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks. Journal of Neuroscience Methods, 293, 53-58. doi: 10.1016/j.jneumeth.2017.08.018

  • Knaupp, Anja S., Buckberry, Sam, Pflueger, Jahnvi, Lim, Sue Mei, Ford, Ethan, Larcombe, Michael R., Rossello, Fernando J., de Mendoza, Alex, Alaei, Sara, Firas, Jaber, Holmes, Melissa L., Nair, Shalima S., Clark, Susan J., Nefzger, Christian M., Lister, Ryan and Polo, Jose M. (2017). Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming. Cell Stem Cell, 21 (6), 834-845+. doi: 10.1016/j.stem.2017.11.007

  • Nefzger, Christian M., Rossello, Fernando J., Chen, Joseph, Liu, Xiaodong, Knaupp, Anja S., Firas, Jaber, Paynter, Jacob M., Pflueger, Jahnvi, Buckberry, Sam, Lim, Sue Mei, Williams, Brenda, Alaei, Sara, Faye-Chauhan, Keshav, Petretto, Enrico, Nilsson, Susan K., Lister, Ryan, Ramialison, Mirana, Powell, David R., Rackham, Owen J. L. and Polo, Jose M. (2017). Cell type of origin dictates the route to pluripotency. Cell Reports, 21 (10), 2649-2660. doi: 10.1016/j.celrep.2017.11.029

  • Liu, Xiaodong, Nefzger, Christian M., Rossello, Fernando J., Chen, Joseph, Knaupp, Anja S., Firas, Jaber, Ford, Ethan, Pflueger, Jahnvi, Paynter, Jacob M., Chy, Hun S., O'Brien, Carmel M., Huang, Cheng, Mishra, Ketan, Hodgson-Garms, Margeaux, Jansz, Natasha, Williams, Sarah M., Blewitt, Marnie E., Nilsson, Susan K., Schittenhelm, Ralf B., Laslett, Andrew L., Lister, Ryan and Polo, Jose M. (2017). Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming. Nature Methods, 14 (11), 1055-1062+. doi: 10.1038/NMETH.4436

  • Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017). Nature Immunology, 18 (11), 1271-1271. doi: 10.1038/ni1117-1271c

  • Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes (vol 18, pg 552, 2017). Nature Immunology, 18 (8), 951-951. doi: 10.1038/ni0817-951c

  • Marino, Eliana, Richards, James L., McLeod, Keiran H., Stanley, Dragana, Yap, Yu Anne, Knight, Jacinta, McKenzie, Craig, Kranich, Jan, Oliveira, Ana Carolina, Rossello, Fernando J., Krishnamurthy, Balasubramanian, Nefzger, Christian M., Macia, Laurence, Thorburn, Alison, Baxter, Alan G., Morahan, Grant, Wong, Lee H., Polo, Jose M., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Topping, David L., Harrison, Leonard C. and Mackay, Charles R. (2017). Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nature Immunology, 18 (5), 552-562. doi: 10.1038/ni.3713

  • Nefzger, Christian M. and Polo, Jose M. (2017). DEAD-box RNA binding protein DDX5: not a black-box during reprogramming. Cell Stem Cell, 20 (4), 419-420. doi: 10.1016/j.stem.2017.03.006

  • O'Brien, Carmel M., Chy, Hun S., Zhou, Qi, Blumenfeld, Shiri, Lambshead, Jack W., Liu, Xiaodong, Kie, Joshua, Capaldo, Bianca D., Chung, Tung-Liang, Adams, Timothy E., Tram Phan,, Bentley, John D., McKinstry, William J., Oliva, Karen, McMurrick, Paul J., Wang, Yu-Chieh, Rossello, Fernando J., Lindeman, Geoffrey J., Chen, Di, Jarde, Thierry, Clark, Amander T., Abud, Helen E., Visvader, Jane E., Nefzger, Christian M., Polo, Jose M., Loring, Jeanne F. and Laslett, Andrew L. (2017). New monoclonal antibodies to defined cell surface proteins on human pluripotent stem cells. Stem Cells, 35 (3), 626-640. doi: 10.1002/stem.2558

  • Alaei, S., Knaupp, A. S., Lim, S. M., Chen, J., Holmes, M. L., Anko, M. L., Nefzger, C. M. and Polo, J. M. (2016). An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3. Stem Cell Research, 17 (1), 49-53. doi: 10.1016/j.scr.2016.05.008

  • Nefzger, Christian M., Jarde, Thierry, Rossello, Fernando J., Horvay, Katja, Knaupp, Anja S., Powell, David R., Chen, Joseph, Abud, Helen E. and Polo, Jose M. (2016). A versatile strategy for isolating a highly enriched population of intestinal stem cells. Stem Cell Reports, 6 (3), 321-329. doi: 10.1016/j.stemcr.2016.01.014

  • Rackham, Owen J. L., Firas, Jaber, Fang, Hai, Oates, Matt E., Holmes, Melissa L., Knaupp, Anja S., Suzuki, Harukazu, Nefzger, Christian M., Daub, Carsten O., Shin, Jay W., Petretto, Enrico, Forrest, Alistair R. R., Hayashizaki, Yoshihide, Polo, Jose M. and Gough, Julian (2016). A predictive computational framework for direct reprogramming between human cell types. Nature Genetics, 48 (3), 331-335. doi: 10.1038/ng.3487

  • Horvay, Katja, Jarde, Thierry, Casagranda, Franca, Perreau, Victoria M., Haigh, Katharina, Nefzger, Christian M., Akhtar, Reyhan, Gridley, Thomas, Berx, Geert, Haigh, Jody J., Barker, Nick, Polo, Jose M., Hime, Gary R. and Abud, Helen E. (2015). Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. The EMBO Journal, 34 (10), 1319-1335. doi: 10.15252/embj.201490881

  • Nefzger, Christian M., Alaei, Sara, Knaupp, Anja S., Holmes, Melissa L. and Polo, Jose M. (2014). Cell surface marker mediated purification of iPS cell intermediates from a reprogrammable mouse model. Jove-Journal of Visualized Experiments (91). doi: 10.3791/51728

  • Firas, Jaber, Liu, Xiaodong, Nefzger, Christian M. and Polo, Jose M. (2014). GM-CSF and MEF-conditioned media support feeder-free reprogramming of mouse granulocytes to iPS cells. Differentiation, 87 (5), 193-199. doi: 10.1016/j.diff.2014.05.003

  • Kelly, Richard D. W., Rodda, Andrew E., Dickinson, Adam, Mahmud, Arsalan, Nefzger, Christian M., Lee, William, Forsythe, John S., Polo, Jose M., Trounce, Ian A., McKenzie, Matthew, Nisbet, David R. and St John, Justin C. (2013). Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells, 31 (4), 703-716. doi: 10.1002/stem.1313

  • Kaur, Gurpreet, Costa, Mauro W., Nefzger, Christian M., Silva, Juan, Fierro-Gonzalez, Juan Carlos, Polo, Jose M., Bell, Toby D. M. and Plachta, Nicolas (2013). Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy. Nature Communications, 4 (1) 1637. doi: 10.1038/ncomms2657

  • Polo, Jose M., Anderssen, Endre, Walsh, Ryan M., Schwarz, Benjamin A., Nefzger, Christian M., Lim, Sue Mei, Borkent, Marti, Apostolou, Effie, Alaei, Sara, Cloutier, Jennifer, Bar-Nur, Ori, Cheloufi, Sihem, Stadtfeld, Matthias, Figueroa, Maria Eugenia, Robinton, Daisy, Natesan, Sridaran, Melnick, Ari, Zhu, Jinfang, Ramaswamy, Sridhar and Hochedlinger, Konrad (2012). A molecular roadmap of reprogramming somatic cells into iPS cells. Cell, 151 (7), 1617-1632. doi: 10.1016/j.cell.2012.11.039

  • Nefzger, Christian M., Su, Colin T., Fabb, Stewart A., Hartley, Brigham J., Beh, Siew J., Zeng, Wendy R., Haynes, John M. and Pouton, Colin W. (2012). Lmx1a allows context-specific isolation of progenitors of GABAergic or Dopaminergic neurons during neural differentiation of embryonic stem cells. Stem Cells, 30 (7), 1349-1361. doi: 10.1002/stem.1105

  • Khaira, S. K., Nefzger, C. M., Beh, S. J., Pouton, C. W. and Haynes, J. M. (2011). Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons. Neurochemistry International, 59 (3), 413-420. doi: 10.1016/j.neuint.2011.02.016

  • Nefzger, Christian M., Haynes, John M. and Pouton, Colin W. (2011). Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem Cells, 29 (6), 928-939. doi: 10.1002/stem.640

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors: