The University of Queensland

Chromatin modifications involved in the DNA damage response to double strand breaks

Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports. doi: 10.1038/s44319-024-00181-y

FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy

Kulkarni, Prajakta, Nguyen-Dien, Giang Thanh, Kozul, Keri-Lyn and Pagan, Julia K. (2024). FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy. Autophagy, 20 (6), 1-3. doi: 10.1080/15548627.2024.2318077

PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy

Niemi, Natalie M., Serrano, Lia R., Muehlbauer, Laura K., Balnis, Catherine E., Wei, Lianjie, Smith, Andrew J., Kozul, Keri-Lyn, Forny, Merima, Connor, Olivia M., Rashan, Edrees H., Shishkova, Evgenia, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Friedman, Jonathan R., Pagan, Julia K., Coon, Joshua J. and Pagliarini, David J. (2023). PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. Nature Communications, 14 (1) 6431, 1-17. doi: 10.1038/s41467-023-42069-w

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

Centrosome reduction promotes terminal differentiation of human cardiomyocytes

Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

Rona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K., Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli and Pagano, Michele (2018). PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. eLife, 7 e38771. doi: 10.7554/eLife.38771.001

PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth

Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo and Pagano, Michele (2017). PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth. Nature, 546 (7659), 554-558. doi: 10.1038/nature22965

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing

Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076

SCF ubiquitin ligase-targeted therapies

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2014). SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery, 13 (12), 889-903. doi: 10.1038/nrd4432

Mechanisms and function of substrate recruitment by F-box proteins

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2013). Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology, 14 (6), 369-381. doi: 10.1038/nrm3582

Role of the ubiquitin proteasome system in the heart

Pagan, Julia, Seto, Tiffany, Pagano, Michele and Cittadini, Antonio (2013). Role of the ubiquitin proteasome system in the heart. Circulation Research, 112 (7), 1046-1058. doi: 10.1161/CIRCRESAHA.112.300521

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

Duan, Shanshan, Cermak, Lukas, Pagan, Julia K., Rossi, Mario, Martinengo, Cinzia, di Celle, Paola Francia, Chapuy, Bjoern, Shipp, Margaret, Chiarle, Roberto and Pagano, Michele (2012). FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature, 481 (7379), 90-94. doi: 10.1038/nature10688

FBXW5 controls centrosome number

Pagan, Julia and Pagano, Michele (2011). FBXW5 controls centrosome number. Nature Cell Biology, 13 (8), 888-890. doi: 10.1038/ncb2312

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization

Bashir, Tarig, Pagan, Julia K., Busino, Luca and Pagano, Michele (2010). Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle, 9 (5), 971-974. doi: 10.4161/cc.9.5.10914

SnapShot: F Box Proteins II

Skaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins II. Cell, 137 (7), 1358-U100. doi: 10.1016/j.cell.2009.05.040

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair

Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947

SnapShot: F Box Proteins I

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins I. Cell, 137 (6), 1358-U100. doi: 10.1016/j.cell.2009.05.039

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200

Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup

Kay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200

The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion

Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X

Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages

Shurety, Wenda, Pagan, Julia K., Prins, Johannes B. and Stow, Jennifer L. (2001). Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages. Laboratory Investigation, 81 (1), 107-117. doi: 10.1038/labinvest.3780216

Regulation of TNF trafficking in macrophages

Pagan, J. K., Wylie, F. G. and Stow, J. L. (2002). Regulation of TNF trafficking in macrophages. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, 14-18 December 2002. Bethesda, MD United States: American Society for Cell Biology.