The University of Queensland

C. elegans as a model to study mitochondrial biology and disease

Onraet, Tessa and Zuryn, Steven (2024). C. elegans as a model to study mitochondrial biology and disease. Seminars in Cell and Developmental Biology, 154 (Part A), 48-58. doi: 10.1016/j.semcdb.2023.04.006

The mechanisms and roles of mitochondrial dynamics in C. elegans

Campbell, Daniel and Zuryn, Steven (2023). The mechanisms and roles of mitochondrial dynamics in C. elegans. Seminars in Cell & Developmental Biology, 156, 266-275. doi: 10.1016/j.semcdb.2023.10.006

ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

Dai, Chuan-Yang, Ng, Chai Chee, Hung, Grace Ching Ching, Kirmes, Ina, Hughes, Laetitia A., Du, Yunguang, Brosnan, Christopher A., Ahier, Arnaud, Hahn, Anne, Haynes, Cole M., Rackham, Oliver, Filipovska, Aleksandra and Zuryn, Steven (2023). ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription. Nature Cell Biology, 25 (8), 1-10. doi: 10.1038/s41556-023-01192-y

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

C. elegans as a model for health and disease

Zuryn, Steven (2023). C. elegans as a model for health and disease. Seminars in Cell and Developmental Biology, 154 (Part A), 1-3. doi: 10.1016/j.semcdb.2023.07.006

LONP-1 aids propagation of deleterious mtDNA

Kirmes, Ina and Zuryn, Steven (2022). LONP-1 aids propagation of deleterious mtDNA. Nature Cell Biology, 24 (2), 127-128. doi: 10.1038/s41556-021-00838-z

Cell-specific mitochondria affinity purification (CS-MAP) from Caenorhabditis elegans

Ahier, Arnaud, Onraet, Tessa and Zuryn, Steven (2021). Cell-specific mitochondria affinity purification (CS-MAP) from Caenorhabditis elegans. STAR Protocols, 2 (4) 100952, 1. doi: 10.1016/j.xpro.2021.100952

Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

Richman, Tara R., Ermer, Judith A., Siira, Stefan J., Kuznetsova, Irina, Brosnan, Christopher A., Rossetti, Giulia, Baker, Jessica, Perks, Kara L., Cserne Szappanos, Henrietta, Viola, Helena M., Gray, Nicola, Larance, Mark, Hool, Livia C., Zuryn, Steven, Rackham, Oliver and Filipovska, Aleksandra (2021). Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan. Aging Cell, 20 (7) e13408, e13408. doi: 10.1111/acel.13408

PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

Ahier, Arnaud, Dai, Chuan-Yang, Kirmes, Ina, Cummins, Nadia, Hung, Grace Ching Ching, Götz, Jürgen and Zuryn, Steven (2021). PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome. Cell Reports, 35 (9) 109203, 109203. doi: 10.1016/j.celrep.2021.109203

Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading

Brosnan, Christopher A., Palmer, Alexander J. and Zuryn, Steven (2021). Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading. Nature Communications, 12 (1) 2194, 1-16. doi: 10.1038/s41467-021-22503-7

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280

Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species

Hahn, Anne and Zuryn, Steven (2019). Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species. Antioxidants, 8 (9) 392, 392. doi: 10.3390/antiox8090392

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

Cummins, Nadia, Tweedie, Andrea, Zuryn, Steven, Bertran‐Gonzalez, Jesus and Götz, Jürgen (2019). Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. The EMBO Journal, 38 (3) e99360, e99360. doi: 10.15252/embj.201899360

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Bezawork-Geleta, Ayenachew, Wen, He, Dong, LanFeng, Yan, Bing, Vider, Jelena, Boukalova, Stepana, Krobova, Linda, Vanova, Katerina, Zobalova, Renata, Sobol, Margarita, Hozak, Pavel, Novais, Silvia Magalhaes, Caisova, Veronika, Abaffy, Pavel, Naraine, Ravindra, Pang, Ying, Zaw, Thiri, Zhang, Ping, Sindelka, Radek, Kubista, Mikael, Zuryn, Steven, Molloy, Mark P., Berridge, Michael V., Pacak, Karel, Rohlena, Jakub, Park, Sunghyouk and Neuzil, Jiri (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications, 9 (1) 2221, 2221. doi: 10.1038/s41467-018-04603-z

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Ahier, Arnaud, Dai, Chuan-Yang, Tweedie, Andrea, Bezawork-Geleta, Ayenachew, Kirmes, Ina and Zuryn, Steven (2018). Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism. Nature Cell Biology, 20 (3), 352-360. doi: 10.1038/s41556-017-0023-x

The Cellular Mitochondrial Genome Landscape in Disease

Hahn, Anne and Zuryn, Steven (2018). The Cellular Mitochondrial Genome Landscape in Disease. Trends in Cell Biology, 29 (3), 227-240. doi: 10.1016/j.tcb.2018.11.004

Sequential histone-modifying activities determine the robustness of transdifferentiation

Zuryn, Steven, Ahier, Arnaud, Portoso, Manuela, White, Esther Redhouse, Morin, Marie-Charlotte, Margueron, Raphaël and Jarriault, Sophie (2014). Sequential histone-modifying activities determine the robustness of transdifferentiation. Science, 345 (6198), 826-829. doi: 10.1126/science.1255885

Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease

Wilkinson, Ray, Wang, Xiangju, Kassianos, Andrew J., Zuryn, Steven, Roper, Kathrein E., Osborne, Andrew, Sampangi, Sandeep, Francis, Leo, Raghunath, Vishwas and Healy, Helen (2014). Laser capture microdissection and multiplex-tandem PCR analysis of proximal tubular epithelial cell signaling in human kidney disease. PLoS One, 9 (1) e87345, e87345.1-e87345.10. doi: 10.1371/journal.pone.0087345

Deep sequencing strategies for mapping and identifying mutations from genetic screens

Zuryn, Steven and Jarriault, Sophie (2013). Deep sequencing strategies for mapping and identifying mutations from genetic screens. Worm, 2 (3), e25081. doi: 10.4161/worm.25081

A core metabolic enzyme mediates resistance to phosphine gas

Schlipalius, David I., Valmas, Nicholas, Tuck, Andrew G., Jagadeesan, Rajeswaran, Ma, Li, Kaur, Ramandeep, Goldinger, Anita, Anderson, Cameron, Kuang, Jujiao, Zuryn, Steven, Mau, Yosep S., Cheng, Qiang, Collins, Patrick J., Nayak, Manoj K., Schirra, Horst Joachim, Hilliard, Massimo A. and Ebert, Paul R. (2012). A core metabolic enzyme mediates resistance to phosphine gas. Science, 338 (6108), 807-810. doi: 10.1126/science.1224951

Direct cellular reprogramming in Caenorhabditis elegans: Facts, models, and promises for regenerative medicine

Zuryn, Steven, Daniele, Thomas and Jarriault, Sophie (2011). Direct cellular reprogramming in Caenorhabditis elegans: Facts, models, and promises for regenerative medicine. WIREs Developmental Biology, 1 (1), 138-152. doi: 10.1002/wdev.7

Direct in vivo reprogramming involves transition through discrete, non-pluripotent steps

Richard, Jai Prakash, Zuryn, Steven, Fischer, Nadine, Pavet, Valeria, Vaucamps, Nadège and Jarriault, Sophie (2011). Direct in vivo reprogramming involves transition through discrete, non-pluripotent steps. Development, 138 (8), 1483-1492. doi: 10.1242/dev.063115

A strategy for direct mapping and identification of mutations by whole-genome sequencing

Zuryn, S., Le Gras, S., Jamet, K. and Jarriault, S. (2010). A strategy for direct mapping and identification of mutations by whole-genome sequencing. Genetics, 186 (1), 427-430. doi: 10.1534/genetics.110.119230

Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

Zuryn, Steven, Kuang, Jujiao, Tuck, Andrew and Ebert, Paul R. (2010). Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity. Mechanisms of Ageing and Development, 131 (9), 554-561. doi: 10.1016/j.mad.2010.07.004

Mitochondrial uncouplers act synergistically with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death

Valmas, Nicholas, Zuryn, Steven and Ebert, Paul R. (2008). Mitochondrial uncouplers act synergistically with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death. Toxicology, 2008 (252), 33-39. doi: 10.1016/j.tox.2008.07.060

Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans

Zuryn, Steven, Kuang, Jujiao and Ebert, Paul (2008). Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Toxicological Sciences, 102 (1), 179-186. doi: 10.1093/toxsci/kfm278

Biochemical mechanisms of phosphine action and resistance

Kuang, J., Zuryn, S., Valmas, N., Cha'on, U, Cui, Y.W., Cheng, Q., Tuck, A., Collins, P.J. and Ebert, P.R. (2008). Biochemical mechanisms of phosphine action and resistance. 8th International Conference on Controlled Atmosphere and Fumigation in Stored Products, Chengdu, China, 21-26 September 2008. China: Sichuan Publishing house of Science & Technology.