The University of Queensland

Targeting chromosomal instability and aneuploidy in cancer

Bhatia, Sugandha, Khanna, Kum Kum and Duijf, Pascal H.G. (2024). Targeting chromosomal instability and aneuploidy in cancer. Trends in Pharmacological Sciences, 45 (3), 210-224. doi: 10.1016/j.tips.2024.01.009

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis

Hancock, Janelle L., Kalimutho, Murugan, Straube, Jasmin, Lim, Malcolm, Gresshoff, Irma, Saunus, Jodi M., Lee, Jason S., Lakhani, Sunil R., Simpson, Kaylene J., Bush, Ashley I., Anderson, Robin L. and Khanna, Kum Kum (2023). COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. Journal of Experimental and Clinical Cancer Research, 42 (1) 90, 1-16. doi: 10.1186/s13046-023-02663-8

Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma

Raninga, Prahlad V., He, Yaowu, Datta, Keshava K., Lu, Xue, Maheshwari, Uma R., Venkat, Pooja, Mayoh, Chelsea, Gowda, Harsha, Kalimutho, Murugan, Hooper, John D. and Khanna, Kum Kum (2023). Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma. Molecular Therapy, 31 (3) ARTN 212011, 729-743. doi: 10.1016/j.ymthe.2022.12.011

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Rashidieh, Behnam, Bain, Amanda Louise, Tria, Simon Manuel, Sharma, Sowmya, Stewart, Cameron Allan, Simmons, Jacinta Ley, Apaja, Pirjo M., Duijf, Pascal H. G., Finnie, John and Khanna, Kum Kum (2023). Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice. Experimental Hematology and Oncology, 12 (1) 4, 1-4. doi: 10.1186/s40164-022-00365-z

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 1-16. doi: 10.1038/s41523-022-00425-x

Targeting BRF2 in cancer using repurposed drugs

Rashidieh, Behnam, Molakarimi, Maryam, Mohseni, Ammar, Tria, Simon Manuel, Truong, Hein, Srihari, Sriganesh, Adams, Rachael C., Jones, Mathew, Duijf, Pascal H. G., Kalimutho, Murugan and Khanna, Kum Kum (2021). Targeting BRF2 in cancer using repurposed drugs. Cancers, 13 (15) 3778, 1-28. doi: 10.3390/cancers13153778

Differential regulation of lacto-/neolacto- glycosphingolipid biosynthesis pathway reveals transcription factors as potential candidates in triple-negative breast cancer

Zeng, Ruichao, Mohamed, Ahmed, Khanna, Kum Kum and Hill, Michelle M. (2021). Differential regulation of lacto-/neolacto- glycosphingolipid biosynthesis pathway reveals transcription factors as potential candidates in triple-negative breast cancer. Cancers, 13 (13) 3330, 1-15. doi: 10.3390/cancers13133330

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis

Ho, Uda Y., Feng, Chun-Wei Allen, Yeap, Yvonne Y., Bain, Amanda L., Wei, Zhe, Shohayeb, Belal, Reichelt, Melissa E., Homer, Hayden, Khanna, Kum Kum, Bowles, Josephine and Ng, Dominic C. H. (2021). WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Communications Biology, 4 (1) 645, 1-14. doi: 10.1038/s42003-021-02171-5

CX-5461 enhances the efficacy of APR-246 via induction of DNA damage and replication stress in triple-negative breast cancer

Makhale, Ashwini, Nanayakkara, Devathri, Raninga, Prahlad, Khanna, Kum Kum and Kalimutho, Murugan (2021). CX-5461 enhances the efficacy of APR-246 via induction of DNA damage and replication stress in triple-negative breast cancer. International Journal of Molecular Sciences, 22 (11) ARTN 5782, 5782. doi: 10.3390/ijms22115782

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E. and Pearson, Richard B. (2020). CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer. Nature Communications, 11 (1) 2641, 1-18. doi: 10.1038/s41467-020-16393-4

Cep55 overexpression promotes genomic instability and tumorigenesis in mice

Sinha, Debottam, Nag, Purba, Nanayakkara, Devathri, Duijf, Pascal H. G., Burgess, Andrew, Raninga, Prahlad, Smits, Veronique A. J., Bain, Amanda L., Subramanian, Goutham, Wall, Meaghan, Finnie, John. W., Kalimutho, Murugan and Khanna, Kum Kum (2020). Cep55 overexpression promotes genomic instability and tumorigenesis in mice. Communications Biology, 3 (1) 593, 1-16. doi: 10.1038/s42003-020-01304-6

The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment

Rabellino, Andrea and Khanna, Kum Kum (2020). The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment. Critical Reviews in Biochemistry and Molecular Biology, 55 (1), 54-70. doi: 10.1080/10409238.2020.1738332

Chromosome arm aneuploidies shape tumour evolution and drug response

Shukla, Ankit, Nguyen, Thu H. M., Moka, Sarat B., Ellis, Jonathan J., Grady, John P., Oey, Harald, Cristino, Alexandre S., Khanna, Kum Kum, Kroese, Dirk P., Krause, Lutz, Dray, Eloise, Fink, J. Lynn and Duijf, Pascal H. G. (2020). Chromosome arm aneuploidies shape tumour evolution and drug response. Nature Communications, 11 (1) 449, 449. doi: 10.1038/s41467-020-14286-0

Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma

Sze, Jun Hui, Raninga, Prahlad V., Nakamura, Kyohei, Casey, Mika, Khanna, Kum Kum, Berners-Price, Susan J., Di Trapani, Giovanna and Tonissen, Kathryn F. (2020). Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma. Redox Biology, 28 101310, 1-12. doi: 10.1016/j.redox.2019.101310

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Raninga, Prahlad, Lee, Andy, Sinha, Debottam, Dong, Lan-feng, Datta, Keshava, Lu, Xue, Kalita-de Croft, Priyakshi, Dutt, Mriga, Hill, Michelle M., Pouliot, Normand M., Gowda, Harsha, Kalimutho, Murugan, Neuzil, Jiri and Khanna, Kum Kum (2020). Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition. Theranostics, 10 (12), 5259-5275. doi: 10.7150/thno.42705

Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer

Raninga, Prahlad V., Lee, Andy C., Sinha, Debottam, Shih, Yu-Yin, Mittal, Deepak, Makhale, Ashwini, Bain, Amanda L., Nanayakarra, Devathri, Tonissen, Kathryn F., Kalimutho, Murugan and Khanna, Kum Kum (2020). Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer. International Journal of Cancer, 146 (1), 123-136. doi: 10.1002/ijc.32410

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018)

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2019). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer (vol 8, 73, 2018). Scientific Reports, 9 ARTN 18771. doi: 10.1038/s41598-019-55020-1

First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation

Zhou, Chenxi, Hancock, Janelle L., Khanna, Kum Kum and Homer, Hayden A. (2019). First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation. Journal of Cell Science, 132 (18) jcs233379, jcs233379. doi: 10.1242/jcs.233379

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Cabrera, Elisa, Raninga, Prahlad, Khanna, Kum Kum and Freire, Raimundo (2019). GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. Cancers, 11 (8), 1073. doi: 10.3390/cancers11081073

Mechanisms of genomic instability in breast cancer

Duijf, Pascal H.G., Nanayakkara, Devathri, Nones, K., Srihari, Sriganesh, Kalimutho, Murugan and Khanna, Kum Kum (2019). Mechanisms of genomic instability in breast cancer. Trends in Molecular Medicine, 25 (7), 595-611. doi: 10.1016/j.molmed.2019.04.004

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

Nones, K., Johnson, J., Newell, F., Patch, A. M., Thorne, H., Kazakoff, S. H., de Luca, X. M., Parsons, M. T., Ferguson, K., Reid, L. E., McCart Reed, A. E., Srihari, S., Lakis, V., Davidson, A. L., Mukhopadhyay, P., Holmes, O., Xu, Q., Wood, S., Leonard, C., The Kathleen Cuningham Foundation Consortium for Research into Familial Aspects of Breast Cancer (kConFab), The Australian Breast Cancer Tissue Bank (ABCTB), The Brisbane Breast Bank (BBB), Beesley, J., Harris, J. M., Barnes, D., Degasperi, A., Ragan, M. A., Spurdle, A. B., Khanna, K. K. ... Simpson, P. T. (2019). Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers. Annals of Oncology, 30 (7) mdz132, 1071-1079. doi: 10.1093/annonc/mdz132

Patterns of genomic instability in breast cancer

Kalimutho, Murugan, Nones, Katia, Srihari, Sriganesh, Duijf, Pascal H.G., Waddell, Nicola and Khanna, Kum Kum (2019). Patterns of genomic instability in breast cancer. Trends in Pharmacological Sciences, 40 (3), 198-211. doi: 10.1016/j.tips.2019.01.005

Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Kalimutho, Murugan, Sinha, Debottam, Mittal, Deepak, Srihari, Sriganesh, Nanayakkara, Devathri, Shafique, Shagufta, Raninga, Prahlad, Nag, Purba, Parsons, Kate and Khanna, Kum Kum (2019). Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer. Journal of Experimental and Clinical Cancer Research, 38 (1) 85, 1-18. doi: 10.1186/s13046-019-1075-5

RNA interference to enhance radiation therapy: targeting the DNA damage response

Ratnayake, G., Bain, A. L., Fletcher, N., Howard, C. B., Khanna, K. K. and Thurecht, K. J. (2018). RNA interference to enhance radiation therapy: targeting the DNA damage response. Cancer Letters, 439, 14-23. doi: 10.1016/j.canlet.2018.09.011

RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination

Harris, Janelle Louise, Rabellino, Andrea and Khanna, Kum Kum (2018). RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination. Annals of Translational Medicine, 6 ARTN S122. doi: 10.21037/atm.2018.12.30

Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy

Prasanna, Thiru, Wu, Fan, Khanna, Kum Kum, Yip, Desmond, Malik, Laeeq, Dahlstrom, Jane E. and Rao, Sudha (2018). Optimizing poly (ADP-ribose) polymerase inhibition through combined epigenetic and immunotherapy. Cancer Science, 109 (11), 3383-3392. doi: 10.1111/cas.13799

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566

The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking

Harris, Janelle L., Dave, Keyur, Gorman, Jeffrey and Khanna, Kum Kum (2018). The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking. International Journal of Biochemistry & Cell Biology, 99, 28-37. doi: 10.1016/j.biocel.2018.03.002

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

Sinha, Debottam, Kalimutho, Murugan, Bowles, Josephine, Chan, Ai-Leen, Merriner, D. Jo, Bain, Amanda L., Simmons, Jacinta L., Freire, Raimundo, Lopez, J Alejandro, Hobbs, Robin M., O'Bryan, Moira K. and Khanna, Kum Kum (2018). Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling. The FASEB Journal, 32 (9), 4984-4999. doi: 10.1096/fj.201701096RR

Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient

Johnson, Julie, Bessette, Darrell C., Saunus, Jodi M., Smart, Chanel E., Song, Sarah, Johnston, Rebecca L., Cocciardi, Sibylle, Rozali, Esdy N., Johnstone, Cameron N., Vargas, Ana Christina, Kazakoff, Stephen H., BioBank, Victorian Cancer, Khanna, Kum Kum, Lakhani, Sunil R., Chenevix-Trench, Georgia, Simpson, Peter T., Nones, Katia, Waddell, Nicola and Al-Ejeh, Fares (2018). Characterization of a novel breast cancer cell line derived from a metastatic bone lesion of a breast cancer patient. Breast Cancer Research and Treatment, 170 (1), 179-188. doi: 10.1007/s10549-018-4719-9

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

Boulding, T., McCuaig, R. D., Tan, A., Hardy, K., Wu, F., Dunn, J., Kalimutho, M., Sutton, C. R., Forwood, J. K., Bert, A. G., Goodall, G. J., Malik, L., Yip, D., Dahlstrom, J. E., Zafar, A., Khanna, K. K. and Rao, S. (2018). LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Scientific Reports, 8 (1) ARTN 73. doi: 10.1038/s41598-017-17913-x

Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families

Li, Jun, Li, Hongyan, Makunin, Igor, Thompson, Bryony A., Tao, Kayoko, Young, Erin L., Lopez, Jacqueline, Camp, Nicola J., Tavtigian, Sean V., John, Esther M., Andrulis, Irene L., Khanna, Kum Kum, Goldgar, David and Chenevix-Trench, Georgia (2017). Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families. Breast Cancer Research and Treatment, 166 (3), 937-949. doi: 10.1007/s10549-017-4469-0

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017). Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 (1), 1-13. doi: 10.1007/s10549-017-4496-x

Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage

Betts, Joshua A., Moradi Marjaneh, Mahdi, Al-Ejeh, Fares, Lim, Yi Chieh, Shi, Wei, Sivakumaran, Haran, Tropee, Romain, Patch, Ann.-Marie, Clark, Michael B., Bartonicek, Nenad, Wiegmans, Adrian P., Hillman, Kristine M., Kaufmann, Susanne, Bain, Amanda L., Gloss, Brian S., Crawford, Joanna, Kazakoff, Stephen, Wani, Shivangi, Wen Shu W., Day, Bryan, Moller, Andreas, Cloonan, Nicole, Pearson,John, Brown, Melissa A., Mercer, Timothy R., Waddell, Nicola, Khanna, Kum Kum, Dray, Eloise, Dinger, Marcel E. ... French, Juliet D. (2017). Long noncoding RNAs CUPID1 and CUPID2 mediate breast cancer risk at 11q13 by modulating the response to DNA damage. American Journal of Human Genetics, 101 (2), 255-266. doi: 10.1016/j.ajhg.2017.07.007

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Peters, A. A., Jamaludin, S. Y. N., Yapa, K. T. D. S., Chalmers, S., Wiegmans, A. P., Lim, H. F., Milevskiy, M. J. G., Azimi, I., Davis, F. M., Northwood, K. S., Pera, E., Marcial, D. L., Dray, E., Waterhouse, N. J., Cabot, P. J., Gonda, T. J., Kenny, P. A., Brown, M. A., Khanna, K. K., Roberts-Thomson, S. J. and Monteith, G. R. (2017). Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene, 36 (46), 6490-6500. doi: 10.1038/onc.2017.234

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

Ward, Ambber, Dong, Lilong, Harris, Jonathan M., Khanna, Kum Kum, Al-Ejeh, Fares, Fairlie, David P., Wiegmans, Adrian P. and Liu, Ligong (2017). Quinazolinone derivatives as inhibitors of homologous recombinase RAD51. Bioorganic and Medicinal Chemistry Letters, 27 (14), 3096-3100. doi: 10.1016/j.bmcl.2017.05.039

Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae

Kalimutho, Murugan, Bain, Amanda L., Mukherjee, Bipasha, Nag, Purba, Nanayakkara, Devathri M., Harten, Sarah K., Harris, Janelle L., Subramanian, Goutham N., Sinha, Debottam, Shirasawa, Senji, Srihari, Sriganesh, Burma, Sandeep and Khanna, Kum Kum (2017). Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. Molecular Oncology, 11 (5), 470-490. doi: 10.1002/1878-0261.12040

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

Shi, Wei, Vu, Therese, Boucher, Didier, Biernacka, Anna, Nde, Jules, Pandita, Raj K., Straube, Jasmin, Boyle, Glen M., Al-Ejeh, Fares, Nag, Purba, Jeffery, Jessie, Harris, Janelle L., Bain, Amanda L., Grzelak, Marta, Skrzypczak, Magdalena, Mitra, Abhishek, Dojer, Norbert, Crosetto, Nicola, Cloonan, Nicole, Becherel, Olivier J., Finnie, John, Skaar, Jeffrey R., Walkley, Carl R., Pandita, Tej K., Rowicka, Maga, Ginalski, Krzysztof, Lane, Steven W. and Khanna, Kum Kum (2017). Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood, 129 (18), 2479-2492. doi: 10.1182/blood-2016-06-725093

Whole-genome landscape of pancreatic neuroendocrine tumours

Scarpa, Aldo, Chang, David K., Nones, Katia, Corbo, Vincenzo, Patch, Ann-Marie, Bailey, Peter, Lawlor, Rita T., Johns, Amber L., Miller, David K., Mafficini, Andrea, Rusev, Borislav, Scardoni, Maria, Antonello, Davide, Barbi, Stefano, Sikora, Katarzyna O., Cingarlini, Sara, Vicentini, Caterina, McKay, Skye, Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, McLean, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wilson, Peter J., Anderson, Matthew J., Fink, J. Lynn ... Grimmond, Sean M. (2017). Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543 (7643), 65-71. doi: 10.1038/nature21063

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

Hernandez-Perez, S., Cabrera, E., Salido, E., Lim, M., Reid, L., Lakhani, S. R., Khanna, K. K., Saunus, J. M. and Freire, R. (2017). DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer. Oncogene, 36 (33), 4802-4809. doi: 10.1038/onc.2017.21

FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition

Jeffery, J. M., Kalimutho, M., Johansson, P., Cardenas, D. G., Kumar, R. and Khanna, K. K. (2017). FBXO31 protects against genomic instability by capping FOXM1 levels at the G2/M transition. Oncogene, 36 (7), 1012-1022. doi: 10.1038/onc.2016.268

The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells

Anderson, Alison M., Kalimutho, Murugan, Harten, Sarah, Nanayakkara, Devathri M., Khanna, Kum Kum and Ragan, Mark A. (2017). The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells. Scientific Reports, 7 (1) 39873. doi: 10.1038/srep39873

Integrating multi-omics data to dissect mechanisms of DNA repair dysregulation in breast cancer

Liu, Chao, Rohart, Florian, Simpson, Peter T., Khanna, Kum Kum, Ragan, Mark A. and Le Cao, Kim-Anh (2016). Integrating multi-omics data to dissect mechanisms of DNA repair dysregulation in breast cancer. Scientific Reports, 6 (1) 34000, 34000.1-34000.11. doi: 10.1038/srep34000

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M., Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine and Hannan, Ross D. (2016). Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget, 7 (31), 49800-49818. doi: 10.18632/oncotarget.10452

High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations

Johnston, Rebecca L., Wockner, Leesa, McCart Reed, Amy E., Wiegmans, Adrian, Chenevix-Trench, Georgia, Khanna, Kum Kum, Lakhani, Sunil R. and Smart, Chanel E. (2016). High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations. Breast Cancer Research, 18 (18) 18, 1-18. doi: 10.1186/s13058-016-0681-9

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

French, Juliet D., Johnatty, Sharon E., Lu, Yi, Beesley, Jonathan, Gao, Bo, Kalimutho, Murugan, Henderson, Michelle J., Russell, Amanda J., Kar, Siddhartha, Chen, Xiaoging, Hillman, Kristine M., Kaufmann, S, Sivakumaran H., O'Reilly, Martin, Wang, Chen, Korbie, Darren J., Lambrechts, Diether, Despierre, Evelyn, Van Nieuwenhuysen, Els, Lambrechts, Sandra, Vergote, Ignace, Karlan, Beth, Lester, Jenny, Orsulic, Sandra, Walsh, Christine, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander ... MacGregor, Stuart (2016). Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer. Oncotarget, 7 (6), 6353-6368. doi: 10.18632/oncotarget.7047

Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease

Kalimutho, Murugan, Parsons, Kate, Mittal, Deepak, Lopez, J.Alejandro, Srihari, Sriganesh and Khanna, Kum Kum (2015). Targeted Therapies for Triple-Negative Breast Cancer: Combating a Stubborn Disease. Trends in Pharmacological Sciences, 36 (12), 822-846. doi: 10.1016/j.tips.2015.08.009

Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance

Saunus, Jodi M., Quinn, MIchael C. J., Patch, Ann-Marie, Pearson, John V., Bailey, Peter J., Nones, Katia, McCart Reed, Amy E., Miller, David, Peter J. Wilson, Al-Ejeh, Fares, Mariasegaram, Mythily, Lau, Queenie, Withers, Teresa, Jeffree, Rosalind L., Reid, Lynne E., Da Silva, Leonard, Matsika, Admire, Niland, Colleen M., Cummings, Margaret C., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Anderson, Matthew J., Fink, J. Lynn ... Lakhani, Sunil R. (2015). Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance. Journal of Pathology, 237 (3), 363-378. doi: 10.1002/path.4583

Differences in expression of key DNA damage repair genes after epigenetic-induced brcaness dictate synthetic lethality with PARP1 inhibition

Wiegmans, Adrian P., Yap, Pei-Yi, Ward, Ambber, Lim, Yi Chieh and Khanna, Kum Kum (2015). Differences in expression of key DNA damage repair genes after epigenetic-induced brcaness dictate synthetic lethality with PARP1 inhibition. Molecular Cancer Therapeutics, 14 (10), 2321-2331. doi: 10.1158/1535-7163.mct-15-0374

Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice

Boucher, Didier, Vu, Therese, Bain, Amanda L., Tagliaro-Jahns, Marina, Shi, Wei, Lane, Steven W. and Khanna, Kum Kum (2015). Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. FASEB Journal, 29 (8), 3326-3334. doi: 10.1096/fj.14-269944

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer

Liu, Chao, Srihari, Sriganesh, Lal, Samir, Gautier, Benoit, Simpson, Peter T., Khanna, Kum Kum, Ragan, Mark A. and LeCao, Kim-Anh (2015). Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. Molecular Oncology, 10 (1), 179-193. doi: 10.1016/j.molonc.2015.09.007

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Bessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015). Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 (5) e0125232, e0125232-e0125232. doi: 10.1371/journal.pone.0125232

Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish

Jeffery, Jessie, Neyt, Christine, Moore, Wade, Paterson, Scott, Bower, Neil I., Chenevix-Trench, Georgia, Verkade, Heather, Hogan, Benjamin M. and Khanna, Kum Kum (2015). Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish. The FASEB Journal, 29 (5), 1999-2009. doi: 10.1096/fj.14-265090

Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis

Jeffery, J., Sinha, D., Srihari, S., Kalimutho, M. and Khanna, K. K. (2015). Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis. Oncogene, 35 (6), 683-690. doi: 10.1038/onc.2015.128

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

Kalousi, Alkmini, Hoffbeck, Anne-Sophie, Selemenakis, Platonas N., Pinder, Jordan, Savage, Kienan I., Khanna, Kum Kum, Brino, Laurent, Dellaire, Graham, Gorgoulis, Vassilis G. and Soutoglou, Evi (2015). The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin. Cell Reports, 11 (1), 149-163. doi: 10.1016/j.celrep.2015.03.005

The Integrator complex controls the termination of transcription at diverse classes of gene targets

Skaar, Jeffrey R., Ferris, Andrea L., Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P., Hughes, Stephen H. and Pagano, Michele (2015). The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Research, 25 (3), 288-305. doi: 10.1038/cr.2015.19

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs

Pandita, Raj K., Chow, Tracy T., Udayakumar, Durga, Bain, Amanda L., Cubeddu, Liza, Hunt, Clayton R., Shi, Wei, Horikoshi, Nobuo, Zhao, Yong, Wright, Woodring E., Khanna, Kum Kum, Shay, Jerry W. and Pandita, Tej K. (2015). Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research, 75 (5), 858-869. doi: 10.1158/0008-5472.CAN-14-2289

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

Momeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754

Complex-based analysis of dysregulated cellular processes in cancer

Srihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014). Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 (Supplement 4) S1. doi: 10.1186/1752-0509-8-S4-S1

SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication

Johansson, Pegah, Jeffery, Jessie, Al-Ejeh, Fares, Schulz, Renèe B., Callen, David F., Kumar, Raman and Khanna, Kum Kum (2014). SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication. Journal of Biological Chemistry, 289 (26), 18514-18525. doi: 10.1074/jbc.M114.559930

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

Al-Ejeh, Fares, Pajic, Marina, Shi, Wei, Kalimutho, Murugan, Miranda, Mariska, Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Grimmond, Sean M., Brown, Michael P. and Khanna, Kum Kum (2014). Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma. Clinical Cancer Research, 20 (12), 3187-3197. doi: 10.1158/1078-0432.CCR-14-0048

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks

Bolderson, Emma, Petermann, Eva, Croft, Laura, Suraweera, Amila, Pandita, Raj K., Pandita, Tej K., Helleday, Thomas, Khanna, Kum Kum and Richard, Derek J. (2014). Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42 (10), 6326-6336. doi: 10.1093/nar/gku276

A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

Liu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014). A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 (10), 6106-6127. doi: 10.1093/nar/gku284

Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer

Al-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014). Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (4) e100, 1-12. doi: 10.1038/oncsis.2014.14

Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer

Al-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014). Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 (10), 3145-3158. doi: 10.18632/oncotarget.1865

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

Tomimatsu, Nozomi, Mukherjee, Bipasha, Catherine Hardebeck, Molly, Ilcheva, Mariya, Vanessa Camacho, Cristel, Louise Harris, Janelle, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum K.um and Burma, Sandeep (2014). Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nature communications, 5 3561. doi: 10.1038/ncomms4561

Rad51 supports triple negative breast cancer metastasis

Wiegmans, Adrian P., Al-Ejeh, Fares, Chee, Nicole, Yap, Pei-Yi, Gorski, Julia J., Da Silva, Leonard, Bolderson, Emma, Chenevix-Trench, Georgia, Anderson, Robin, Simpson, Peter T., Lakhani, Sunil R. and Khanna, Kum Kum (2014). Rad51 supports triple negative breast cancer metastasis. Oncotarget, 5 (10), 3261-3272. doi: 10.18632/oncotarget.1923

Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells

Speckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001

Tumor protein D52 represents a negative regulator of ATM protein levels

Chen, Yuyan, Kamili, Alvin, Hardy, Jayne R., Groblewski, Guy E., Khanna, Kum Kum and Byrne, Jennifer A. (2013). Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle, 12 (18), 3083-3097. doi: 10.4161/cc.26146

Mouse models uncap novel roles of SSBs

Bain, Amanda L., Shi, Wei and Khanna, Kum Kum (2013). Mouse models uncap novel roles of SSBs. Cell Research, 23 (6), 744-745. doi: 10.1038/cr.2013.63

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

Al-Ejeh, Fares, Shi, Wei, Miranda, Mariska, Simpson, Peter T., Vargas, Ana Cristina, Song, Sarah, Wiegmans, Adrian P., Swarbrick, Alex, Welm, Alana L., Brown, Michael P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2013). Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. Journal of Nuclear Medicine, 54 (6), 913-921. doi: 10.2967/jnumed.112.111534

Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment

Jeffery, Jessie M., Grigoriev, Ilya, Poser, Ina, van der Horst, Armando, Hamilton, Nicholas, Waterhouse, Nigel, Bleier, Jonathan, Subramaniam, V. Nathan, Maly, Ivan V., Akhmanova, Anna and Khanna, Kum Kum (2013). Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment. Cell Cycle, 12 (6), 899-906. doi: 10.4161/cc.23879

EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme

Day, Bryan W., Stringer, Brett W., Al-Ejeh, Fares, Ting, Michael J., Wilson, John, Ensbey, Kathleen S., Jamieson, Paul R., Bruce, Zara C., Lim, Yi Chieh, Offenhauser, Carolin, Charmsaz, Sara, Cooper, Leanne T., Ellacott, Jennifer K., Harding, Angus, Leveque, Lucie, Inglis, Po, Allan, Suzanne, Walker, David G., Lackmann, Martin, Osborne, Geoffrey, Khanna, Kum Kum, Reynolds, Brent A., Lickliter, Jason D. and Boyd, Andrew W. (2013). EphA3 Maintains Tumorigenicity and Is a Therapeutic Target in Glioblastoma Multiforme. Cancer Cell, 23 (2), 238-248. doi: 10.1016/j.ccr.2013.01.007

Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2

Shi, Wei, Bain, Amanda L., Schwer, Bjoern, Al-Ejeh, Fares, Smith, Corey, Wong, Lee, Chai, Hua, Miranda, Mariska S., Ho, Uda, Kawaguchi, Makoto, Miura, Yutaka, Finnie, John W., Wall, Meaghan, Heierhorst, Jorg, Wicking, Carol, Spring, Kevin J., Alt, Frederick W. and Khanna, Kum Kum (2013). Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genetics, 9 (2) e1003298, e1003298.1-e1003298.19. doi: 10.1371/journal.pgen.1003298

Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial Cells

Chiu, Yung-Tuen, Liu, Ji, Tang, Kaidun, Wong, Yong-Chuan, Khanna, Kum Kum and Ling, Ming-Tat (2012). Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial Cells. Plos One, 7 (12) ARTN e51108. doi: 10.1371/journal.pone.0051108

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

Noll, J. E., Jeffery, J., Al-Ejeh, F., Kumar, R., Khanna, K. K., Callen, D. F. and Neilsen, P. M. (2012). Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11. Oncogene, 31 (23), 2836-2848. doi: 10.1038/onc.2011.456

A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure

Luijsterburg, Martijn S., Acs, Klara, Ackermann, Leena, Wiegant, Wouter W., Bekker-Jensen, Simon, Larsen, Dorthe H., Khanna, Kum Kum, van Attikum, Haico, Mailand, Niels and Dantuma, Nico P. (2012). A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. Embo Journal, 31 (11), 2511-2527. doi: 10.1038/emboj.2012.104

INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells

Morris, Christelle, Tomimatsu, Nozomi, Richard, Derek J., Cluet, David, Burma, Sandeep, Khanna, Kum Kum and Jalinot, Pierre (2012). INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Research, 72 (8), 2006-2016. doi: 10.1158/0008-5472.CAN-11-2562

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

Tomimatsu, Nozomi, Mukherjee, Bipasha, Deland, Katherine, Kurimasa, Akihiro, Bolderson, Emma, Khanna, Kum Kum and Burma, Sandeep (2012). Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair, 11 (4), 441-448. doi: 10.1016/j.dnarep.2012.01.006

Tocotrienol as a potential anticancer agent

Ling, Ming T., Luk, Sze U., Al-Ejeh, Fares and Khanna, Kum K. (2012). Tocotrienol as a potential anticancer agent. Carcinogenesis, 33 (2), 233-239. doi: 10.1093/carcin/bgr261

Potential roles for prions and protein-only inheritance in cancer

Antony, H., Wiegmans, A. P., Wei, M. Q., Chernoff, Y. O., Khanna, K. K. and Munn, A. L. (2012). Potential roles for prions and protein-only inheritance in cancer. Cancer metastasis reviews, 31 (1-2), 1-19. doi: 10.1007/s10555-011-9325-9

ATM protein kinase: The linchpin of cellular defenses to stress

Bhatti, Shahzad, Kozlov, Sergei, Farooqi, Ammad Ahmad, Naqi, Ali, Lavin, Martin and Khanna, Kum Kum (2011). ATM protein kinase: The linchpin of cellular defenses to stress. Cellular and Molecular Life Sciences, 68 (18), 2977-3006. doi: 10.1007/s00018-011-0683-9

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons

Jung, Cha-Gyun, Uhm, Kyung-Ok, Miura, Yutaka, Hosono, Takashi, Horike, Hirofumi, Khanna, Kum Kum, Kim, Mi-Jeong and Michikawa, Makoto (2011). Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons. Molecular Neurodegeneration, 6 (47) 47, 1-14. doi: 10.1186/1750-1326-6-47

Rare variants in the ATM gene and risk of breast cancer

Goldgar, David E., Healey, Sue, Dowty, James G., Da Silva, Leonard, Chen, Xiaoqing, Spurdle, Amanda B., Terry, Mary B., Daly, Mary J., Buys, Saundra M., Southey, Melissa C., Andrulis, Irene, John, Esther M., Breast Cancer Family Registry, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Khanna, Kum K., Hopper, John L., Oefner, Peter J., Lakhani, Sunil and Chenevix-Trench, Georgia (2011). Rare variants in the ATM gene and risk of breast cancer. Breast Cancer Research, 13 (4) R73, R73-1-R73-9. doi: 10.1186/bcr2919

Breast cancer stem cells: Treatment resistance and therapeutic opportunities

AL-Ejeh, Fares, Smart, Chanel E., Morrison, Brian J., Chenevix-Trench, Georgia, Lopez, J. Alejandro, Lakhani, Sunil R., Brown, Michael P. and Khanna, Kum Kum (2011). Breast cancer stem cells: Treatment resistance and therapeutic opportunities. Carcinogenesis, 32 (5), 650-658. doi: 10.1093/carcin/bgr028

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

Richard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F. and Khanna, Kum Kum (2011). hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research, 39 (9), 3643-3651. doi: 10.1093/nar/gkq1340

A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice

Youngson, N. A., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J. S., Khanna, K. K., de Kretser, D. M. and Whitelaw, Emma (2011). A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mammalian Genome, 22 (3-4), 235-248. doi: 10.1007/s00335-011-9317-7

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

Richard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, Chen, David J., White, Malcolm F., Richard, Kerry, Prise, Kevin M., Schettino, Giuseppe and Khanna, Kum Kum (2011). hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research, 39 (5), 1692-1702. doi: 10.1093/nar/gkq1098

Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges

Simpson, Peter T., Vargas, Ana Christina, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2011). Application of molecular findings to the diagnosis and management of breast disease: Recent advances and challenges. Human Pathology, 42 (2), 153-165. doi: 10.1016/j.humpath.2010.07.008

Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families

Johnson, Julie, Healey, Sue, Khanna, Kum Kum, kConFab and Chenevix-Trench, Georgia (2011). Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families. Breast Cancer Research and Treatment, 129 (1), 255-263. doi: 10.1007/s10549-011-1539-6

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Schoenmakers, Erik, Agostini, Maura, Mitchell, Catherine, Schoenmakers, Nadia, Papp, Laura, Rajanayagam, Odelia, Padidela, Raja, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Prevosto, Claudia, Luan, Jian'an, Montano, Sergio, Lu, Jun, Castanet, Mireille, Clemons, Nick, Groeneveld, Matthijs, Castets, Perrine, Karbaschi, Mahsa, Aitken, Sri, Dixon, Adrian, Williams, Jane, Campi, Irene, Blount, Margaret, Burton, Hannah, Muntoni, Francesco, O'Donovan, Dominic, Dean, Andrew, Warren, Anne, Brierley, Charlotte ... Chatterjee, Krishna (2010). Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Journal of Clinical Investigation, 120 (12), 4220-4235. doi: 10.1172/JCI43653

Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes

Al-Ejeh, F., Kumar, R., Wiegmans, A., Lakhani, S.R., Brown, M.P. and Khanna, K.K. (2010). Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene, 29 (46), 6085-6098. doi: 10.1038/onc.2010.407

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

Kim, TS, Kawaguchi, M, Suzuki, M, Jung, CG, Asai, K, Shibamoto, Y, Lavin, MF, Khanna, KK and Miura, Y (2010). The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. DMM Disease Models and Mechanisms, 3 (11-12), 752-762. doi: 10.1242/dmm.004689

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation

Hinz, Michael, Stilmann, Michael, Arslan, Seda Çöl, Khanna, Kum Kum, Dittmar, Gunnar and Scheidereit, Claus (2010). A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular Cell, 40 (1), 63-74. doi: 10.1016/j.molcel.2010.09.008

Subtypes of familial breast tumours revealed by expression and copy number profiling

Waddell, N, Arnold, J, Cocciardi, S, da Silva, L, Marsh, A, Riley, J, Johnstone, CN, Orloff, M, Assie, G, Eng, C, Reid, L, Keith, P, Yan, M, Fox, S, Devilee, P, Godwin, AK, Hogervorst, FBL, Couch, F, Grimmond, S, Flanagan, JM, Khanna, K, Simpson, PT, Lakhani, SR, Chenevix-Trench, G and kConFab Investigators (2010). Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Research And Treatment, 123 (3), 661-677. doi: 10.1007/s10549-009-0653-1

Novel single stranded DNA binding proteins crucial for the DNA damage response

Cubeddu, L., Richard, D. J., White, M. F. and Khanna, K. K. (2010). Novel single stranded DNA binding proteins crucial for the DNA damage response. The FEBS Journal, 277 (Supp. 1), 193-193. doi: 10.1111/j.1742-4658.2010.07680.x

Centrobin regulates the assembly of functional mitotic spindles

Jeffery, J. M., Urquhart, A. J., Subramaniam, V. N., Parton, R.G. and Khanna, K.K. (2010). Centrobin regulates the assembly of functional mitotic spindles. Oncogene, 29 (18), 2649-2658. doi: 10.1038/onc.2010.37

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

Bolderson, Emma, Tomimatsu, Nozomi, Richard, Derek J., Boucher, Didier, Kumar, Rakesh, Pandita, Tej K., Burma, Sandeep and Khanna, Kum Kum (2010). Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Research, 38 (6) gkp1164, 1821-1831. doi: 10.1093/nar/gkp1164

SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress

Papp, Laura V., Lu, Jun, Bolderson, Emma, Boucher, Didier, Singh, Ravindra, Holmgren, Arne and Khanna, Kum Kum (2010). SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxidants and Redox Signaling, 12 (7), 797-808. doi: 10.1089/ars.2009.2913

Selenium and selenoproteins in health and disease

Papp, Laura V., Holmgren, Arne and Khanna, Kum Kum (2010). Selenium and selenoproteins in health and disease. Antioxidants and Redox Signaling, 12 (7), 793-795. doi: 10.1089/ars.2009.2973

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

Flanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 (3), 420-433. doi: 10.1016/j.ajhg.2010.02.008

Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?

Lakhani, Sunil R., Khanna, Kum K. and Chenevix-Trench, Georgia (2010). Are estrogen receptor-positive breast cancers in BRCA1 mutation carriers sporadic?. Breast Cancer Research, 12 (2) 104, 104-1-104-2. doi: 10.1186/bcr2483

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Da Silva, Leonard, Simpson, Peter T., Smart, Chanek E., Cocciardi, Sibylle, Waddell, Nic, Lane, Annette, Morrison, Brian J., Vargas, Ana Cristina, Healey, Sue, Beesley, Jonathan, Pakkiri, Pria, Parry, Suzanne, Kurniawan, Nyoman, Reid, Lynne, Keith, Patricia, Faria, Paulo, Pereira, Emilio, Skalova, Alena, Bilous, Michael, Balleine, Rosemary L., Do, Hongdo, Dobrovic, Alexander, Fox, Stephen, Franco, Marcello, Reynolds, Brent, Khanna, Kum Kum, Cummings, Margaret, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2010). HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer. Breast Cancer Research, 12 (4) R46, R46-1-R46-11. doi: 10.1186/bcr2603

Cep55 stabilization is required for normal execution of cytokinesis

Armando van der Horst, Jacinta Simmons and Kum Kum Khanna (2009). Cep55 stabilization is required for normal execution of cytokinesis. Cell Cycle, 8 (22), 3742-3749. doi: 10.4161/cc.8.22.10047

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

Emma Bolderson, Derek J. Richard, Bin-Bing S. Zhou and Kum Kum Khanna (2009). Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair. Clinical Cancer Research, 15 (20), 6314-6320. doi: 10.1158/1078-0432.CCR-09-0096

Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X)

Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp and Samuel Refetoff (2009). Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X). Journal of Clinical Endocrinology and Metabolism, 94 (10), 4003-4009. doi: 10.1210/jc.2009-0686

INTS3 controls the hSSB1-mediated DNA damage response

Jeffrey R. Skaar, Derek J. Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P. Washburn, Kum Kum Khanna and Michele Pagano (2009). INTS3 controls the hSSB1-mediated DNA damage response. The Journal of Cell Biology, 187 (1), 25-32. doi: 10.1083/jcb.200907026

The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55

Armando van der Horst and Kum Kum Khanna (2009). The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55. Cancer Research, 69 (16), 6651-6659. doi: 10.1158/0008-5472.CAN-09-0825

hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response

Yongjiang Li, Emma Bolderson, Rakesh Kumar, Parameswary A. Muniandy, Yutong Xue, Derek J. Richard, Michael Seidman, Tej K. Pandita, Kum Kum Khanna and Weidong Wang (2009). hSSB1 and hSSB2 Form Similar Multiprotein Complexes That Participate in DNA Damage Response. Journal of Biological Chemistry, 284 (35), 23525-23531.. doi: 10.1074/jbc.C109.039586

Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair

Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis

Richard‌, Derek J., Bolderson‌, Emma and Khanna, Kum Kum (2009). Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis. Critical Reviews in Biochemistry and Molecular Biology, 44 (2-3), 98-116. doi: 10.1080/10409230902849180

Involvement of Exo1b in DNA damage-induced apoptosis

Emma Bolderson, Derek J. Richard, Winfried Edelmann and Kum Kum Khanna (2009). Involvement of Exo1b in DNA damage-induced apoptosis. Nucleic Acids Research, 37 (10), 3452-3463. doi: 10.1093/nar/gkp194

The actin-binding and bundling protein, EPLIN, is required for cytokinesis

Megan Chircop, Vanessa Oakes, Mark E. Graham, Maggie P.C. Ma, Charlotte M. Smith, Phillip J. Robinson and Kum Kum Khanna (2009). The actin-binding and bundling protein, EPLIN, is required for cytokinesis. Cell Cycle, 8 (5), 757-764. doi: 10.4161/cc.8.5.7878

Functional characterization of alternatively spliced human SECISBP2 transcript variants

Papp, Laura V., Wang, Junning, Kennedy, Derek, Boucher, Didier, Zhang, Yan, Gladysheve, Vadim N., Sing, Ravindra N. and Khanna, Kum Kum (2008). Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Research, 36 (22), 7192-7206. doi: 10.1093/nar/gkn829

Correction: BCoR-L1 variation and breast cancer

Lose, Felicity, Arnold, Jeremy, Young, David B., Brown, Carolyn J., Mann, Graham J., Pupo, Gulietta M., Khanna, Kum K., Chenevix-Trench, Georgia and Spurdle, Amanda B. (2008). Correction: BCoR-L1 variation and breast cancer. Breast Cancer Research, 10 (5) 406. doi: 10.1186/bcr2153

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

Richard, Derek J., Bolderson, Emma, Cubeddu, Liza, Wadsworth, Ross I. M., Savage, Kienan, Sharma, Girdhar G., Nicolette, Matthew L., Tsvetanov, Sergie, McIlwraith, Michael J., Pandita, Raj K., Takeda, Shunichi, Hay, Ronald T., Gautier, Jean, West, Stephen C., Paull, Tanya T., Pandita, Tej K., White, Malcolm F. and Khanna, Kum Kum (2008). Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature, 453 (7195), 677-681. doi: 10.1038/nature06883

Mutation analysis of five candidate genes in familial breast cancer

Marsh, Anna, Healey, Sue, Lewis, Aaron, Spurdle, Amanda B., Kedda, Mary Anne, Khanna, Kum Kum, Mann, Graham J., Pupo, Gulietta M., Lakhani, Sunil R. and Chenevix-Trench, Georgia (2007). Mutation analysis of five candidate genes in familial breast cancer. Breast Cancer Research & Treatment, 105 (3), 377-389. doi: 10.1007/s10549-006-9461-z

A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200

Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer

Pylkas, K, Tommiska, J, Syrjakoski, K, Kere, J, Gatei, M, Waddell, N, Allinen, M, Karppinen, SM, Rapakko, K, Kaariainen, H, Aittomaki, K, Blomqvist, C, Mustonen, A, Holli, K, Khanna, KK, Kallioniemi, OP, Nevanlinna, H and Winqvist, R (2007). Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. Carcinogenesis, 28 (5), 1040-1045. doi: 10.1093/carcin/bgl237

From selenium to selenoproteins: Synthesis, identity, and their role in human health

Papp, Laura Vanda, Lu, Jun, Holmgren, Arne and Khanna, Kum Kum (2007). From selenium to selenoproteins: Synthesis, identity, and their role in human health. Antioxidants & Redox Signaling, 9 (7), 775-806. doi: 10.1089/ars.2007.1528

BCoR-L1 variation and breast cancer

Lose, Felicity, Arnold, Jeremy, Young, David B., Brown, Carolyn J., Mann, Graham J., Pupo, Gulietta M., Khanna, Kum Kum, Chenevix-Trench, Georgia and Spurdle, Amanda B. (2007). BCoR-L1 variation and breast cancer. Breast Cancer Research, 9 (4) R54, 1-12. doi: 10.1186/bcr1759

Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling

Waddell, Nic, Jonnalagadda, Jyoti, Marsh, Anna, Grist, Scott, Jenkins, Mark, Hobson, Karen, Taylor, Malcolm, Lindeman, Geoff J., Tavtigian, Sean V., Suthers, Graeme, Goldgar, David, Oefner, Peter J., kConFab Investigators, Taylor, Darrin, Grimmond, Sean, Khanna, Kum Kum and Chenevix-Trench, Georgia (2006). Characterization of the breast cancer associated ATM 7271T>G (V2424G) mutation by gene expression profiling. Genes Chromosomes and Cancer, 45 (12), 1169-1181. doi: 10.1002/gcc.20381

Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint

Bruno, Tiziana, De Nicola, Francesca, Iezzi, Simona, Lecis, Daniele, D'Angelo, Carmen, Di Padova, Monica, Corbi, Nicoletta, Dimiziani, Leopoldo, Zannini, Laura, Jekimovs, Christian, Scarsella, Marco, Porrello, Alessandro, Chersi, Alberto, Crescenzi, Marco, Leonetti, Carlo, Khanna, Kum Kum, Soddu, Silvia, Floridi, Aristide, Passananti, Claudio, Domenico Delia and Fanciulli, Maurizio (2006). Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell, 10 (6), 473-486. doi: 10.1016/j.ccr.2006.10.012

EDD mediates DNA damage-induced activation of CHK2

Henderson, Michelle J., Munoz, Marcia A, Saunders, Darren N., Clancy, Jennifer L., Russell, Amanda J., Williams, Brandi, Pappin, Darryl, Khanna, Kum Kum, Jackson, Stephen P., Sutherland, Robert L. and Watts, Colin K. W. (2006). EDD mediates DNA damage-induced activation of CHK2. Journal of Biological Chemistry, 281 (52), 39990-40000. doi: 10.1074/jbc.M602818200

Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

Deans, Andrew J., Khanna, Kum Kum, McNees, Carolyn J., Mercurio, Ciro, Heierhorst, Jörg and McArthur, Grant A. (2006). Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Research, 66 (16), 8219-8226. doi: 10.1158/0008-5472.CAN-05-3945

BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells

Kang, Hyo Jin, Kim, Hee Jeong, Kim, Sang Keun, Barouki, Robert, Cho, Chi-Heum, Khanna, Kum Kum, Rosen, Eliot M. and Bae, Insoo (2006). BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. The Journal of Biological Chemistry., 281 (21), 14654-14662. doi: 10.1074/jbc.M601613200

Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage

Khanna, Kum Kum, Gatei, Magtouf and Tribbick, Gordon (2006). Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage. Methods in Molecular Medicine, 120, 441-452. doi: 10.1385/1-59259-969-9:441

The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function

Papp, Laura V., Lu, Jun, Striebel, Frank, Kennedy, Derek, Holmgren, Arne and Khanna, Kum Kum (2006). The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. Molecular & Cellular Biology, 26 (13), 4895-4910. doi: 10.1128/MCB.02284-05

Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation

Jung, Cha-Gyun, Kim, Hye-Jung, Kawaguchi, Makoto, Khanna, Kum Kum, Hida, Hideki, Asai, Kiyofumi, Nishino, Hitoo and Miura, Yutaka (2005). Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Development, 132 (23), 5137-5145. doi: 10.1242/dev.02098

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association

Young, David B., Jonnalagadda, Jyoti, Gatei, Magtouf, Jans, David A., Meyn, Stephen and Khanna, Kum Kum (2005). Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. The Journal of Biological Chemistry, 280 (30), 27587-27594. doi: 10.1074/jbc.M411689200

Involvement of human MOF in ATM function

Gupta, Arun, Sharma, Girdhar G., Young, Charles S. H., Agarwal, Manjula, Smith, Edwin R., Paull, Tanya T., Lucchesi, John C., Khanna, Kum Kum, Ludwig, Thomas and Pandita, Tej K. (2005). Involvement of human MOF in ATM function. Molecular and Cellular Biology, 25 (12), 5292-5305. doi: 10.1128/MCB.25.12.5292-5305.2005

Two ATM variants and breast cancer risk

Thompson, Deborah, Antoniou, Antonis C., Jenkins, Mark, Marsh, Anna, Chen, Xiaoqing, Wayne, Tierney, Tesoriero, Andrea, Milne, Roger, Spurdle, Amanda, Thorstenson, Yvonne, Southey, Melissa, Giles, Graham G., kConFab Investigators,, Khanna, Kum Kum, Sambrook, Joseph, Oefner, Peter, Goldgar, David, Hopper, John L., Easton, Doug and Chenevix-Trench, Georgia (2005). Two ATM variants and breast cancer risk. Human Mutation, 25 (6), 594-595. doi: 10.1002/humu.9344

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis

Fabbro, Megan, Zhou, Bin-Bing, Takahasi, Mikiko, Sarcevic, Boris, Lal, Preeti, Graham, Mark E., Gabrielli, Brian G., Robinson, Phillip J., Nigg, Erich A., Ono, Yoshitaka and Khanna, Kum Kum (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9 (4), 477-488. doi: 10.1016/j.devcel.2005.09.003

Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals

Jekimovs, C. R., Chen, X., Arnold, J., Gatei, M., Richardson, D. J., kConFab Investigators, Spurdle, A. B., Khanna, K. K. and Chenevix-Trench, G. (2005). Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. British Journal Of Cancer, 92 (4), 784-790. doi: 10.1038/sj.bjc.6602381

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

Goodarzi, Aaron A, Jonnalagadda, Jyoti C., Douglas, Pauline, Young, David, Ye, Ruiqiong, Moorhead, Greg B. G., Lees-Miller, Susan P. and Khanna, Kum Kum (2004). Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The EMBO Journal, 23 (22), 4451-4461. doi: 10.1038/sj.emboj.7600455

ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility

Khanna, Kum Kum and Chenevix-Trench, Georgia (2004). ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility. Journal of Mammary Gland Biology and Neoplasia, 9 (3), 247-262. doi: 10.1023/B:JOMG.0000048772.92326.a1

Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks

Buscemi, Giacomo, Perego, Paola, Carenini, Nives, Nakanishi, Makoto, Chessa, Luciana, Chen, Junjie, Khanna, Kum Kum and Delia, Domenico (2004). Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene, 23 (46), 7691-7700. doi: 10.1038/sj.onc.1207986

BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

Fabbro, Megan, Savage, Kienan, Hobson, Karen, Deans, Andrew J., Powell, Simon N., McArthur, Grant A. and Khanna, Kum Kum (2004). BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. The Journal of Biological Chemistry., 279 (30), 31251-31258. doi: 10.1074/jbc.M405372200

Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1

Krause, Darren R., Jonnalagadda,Jyoti C., Gatei, Magtouf H., Sillje, Herman H. W., Zhou, Bin-Bing, Nigg, Erich A. and Khanna, Kumkum (2003). Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene, 22 (38), 5927-5937. doi: 10.1038/sj.onc.1206691

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

Gatei, Magtouf, Sloper, Katie, Sorensen, Claus, Syljuasen, Randi, Falck, Jacob, Hobson, Karen, Savage, Kienan, Lukas, Jiri, Zhou, Bin-Bing, Bartek, Jiri and Khanna, Kum Kum (2003). Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278 (17), 14806-14811. doi: 10.1074/jbc.M210862200

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sorensen, Claus Storgaard, Syluasen, Randi G., Falck, Jacob, Schroeder, Tine, Ronnstrand, Lars, Khanna, Kum Kum, Zhou, Bin-Bing, Bartek, Jiri and Lukas, Jiri (2003). Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3 (3), 247-258. doi: 10.1016/S1535-6108(03)00048-5

Role of tumor suppressors in DNA damage response

Zhou, Bin-Bing S., Mattern, Michael R. and Khanna, Kum Kum (2003). Role of tumor suppressors in DNA damage response. Methods in Molecular Biology, 223, 39-50. doi: 10.1385/1592593291

Dominant negative ATM mutations in breast cancer families

Chenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret C., Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R. E., Hopper, John L., Sambrook, Joseph, Mann, Graham J. and Khanna, Kum Kum (2002). Dominant negative ATM mutations in breast cancer families. Journal of the National Cancer Institute, 94 (3), 205-215. doi: 10.1093/jnci/94.3.205

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

Brown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002). Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 (5), 467-478. doi: 10.1023/A:1020348025139

No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer

Spurdle, Amanda B., Hopper, John L., Chen, Xiaoqing, McCredie, Margaret R. E., Giles, Graham G., Newmann, Beth, Chenevix-Trench, Georgia and Khanna, KumKum (2002). No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer. Breast Cancer Research, 4 (6) R15, R15/1-R15/6. doi: 10.1186/bcr534

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies

Gatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001). Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 (20), 17276-17280. doi: 10.1074/jbc.M011681200

UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM protein

Oakley, G. G., Loberg, L. I., Yao, J. Q., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P. and Dixon, K. (2001). UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM protein. Molecular Biology of The Cell, 12 (5), 1199-1213. doi: 10.1091/mbc.12.5.1199

Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia

Gueven, Nuri, Keating, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001). Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. Journal of Biological Chemistry, 276 (12), 8884-8891. doi: 10.1074/jbc.M006190200

ATM, a central controller of cellular responses to DNA damage

Khanna, K. K., Lavin, M. F., Jackson, S. P. and Mulhern, T. D. (2001). ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 (11), 1052-1065. doi: 10.1038/sj.cdd.4400874

Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid

Gatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001). Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 (3), 289-294. doi: 10.1038/sj.onc.1204111

Chk2 activation dependence on Nbs1 after DNA damage

Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001). Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 (15), 5214-5222. doi: 10.1128/MCB.21.15.5214-5222.2001

DNA double-strand breaks: signaling, repair and the cancer connection

Jackson, S.P. and Khanna, K. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 (3), 247-254. doi: 10.1038/85798

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

Ye, R. Q., Bodero, A., Zhou, B. B., Khanna, K. K., Lavin, M. F. and Lees-Miller, S. P. (2001). The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. Journal of Biological Chemistry, 276 (7), 4828-4833. doi: 10.1074/jbc.M004894200

Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53

Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118

Defective radiation signal transduction in ataxia-telangiectasia cells

Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035.

Purification and characterization of ATM from human placenta

Chan, D., Son, S-C., Block, W., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P. J. G., Goodarzi, A. A., Pelley, J., Taya, Y., Lavin, M. F. and Lees-Miller, S. P. (2000). Purification and characterization of ATM from human placenta. Journal of Biological Chemistry, 275 (11), 7803-7810. doi: 10.1074/jbc.275.11.7803

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 (1), 115-119. doi: 10.1038/75508

Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

Zhou, B., Chaturvedi, P.S., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R.G., Mattern, M. R., Winkler, J. D. and Khanna, K. K. (2000). Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. Journal of Biological Chemistry, 275 (14), 10342-10348. doi: 10.1074/jbc.275.14.10342

Cancer risk and the ATM gene: a continuing debate

Khanna, Kum Kum (2000). Cancer risk and the ATM gene: a continuing debate. Journal of the National Cancer Institute, 92 (10), 795-802. doi: 10.1093/jnci/92.10.795

Defective radiation signal transduction in ataxia-telangiectasia cells

Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497

Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1)

Dicker, A., Serewko, M. S., Dahler, A. L., Khanna, K. K., Kaur, P., Li, A., Strutton, G. and Saunders, N. A. (2000). Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). Experimental Cell Research, 258 (2), 352-360. doi: 10.1006/excr.2000.4944

Role for ATM in DNA damage-induced phosphorylation of BRCA1

Gatei, M., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. and Khanna, K. (2000). Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Research, 60 (12), 3299-3304.

p73 is up-regulated in a subset of hepatocellular carcinomas

Herath, NI, Kew, MC, Whitehall, VLJ, Walsh, MD, Jass, JR, Khanna, KK, Young, J, Powell, LW, Leggett, BA and Macdonald, GA (2000). p73 is up-regulated in a subset of hepatocellular carcinomas. Hepatology, 31 (3), 601-605. doi: 10.1002/hep.510310309

Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target

Imyanitov, Evgeny N., Birrell, Geoff W., Filippovich, Igor, Sorokina, Natasha, Arnold, Jeremy, Mould, Michelle A., Wright, Kim, Walsh, Michael, Mok, Samuel C ., Lavin, Martin F., Chenevix-Trench, Georgia and Khanna, Kum Kum (1999). Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target. Oncogene, 18 (32), 4640-4642. doi: 10.1038/sj.onc.1202863

CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia

Chen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999). CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 (1), 249-256. doi: 10.1038/sj.onc.1202257

ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia

Lavin, M. F. and Khanna, K. K. (1999). ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia. International Journal of Radiation Biology, 75 (10), 1201-1214.

Calpain activation is upstream of caspases in radiation-induced apoptosis

Waterhouse, Nigel J., Finucane, Debra M., Green, Douglas R., Elce, John S., Kumar, Sharad, Alnemri, Emad S., Litwack, Gerald, Khanna, Kumkum, Lavin, Martin F. and Watters, Dianne J. (1998). Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death and Differentiation, 5 (12), 1051-1061. doi: 10.1038/sj.cdd.4400425

Cloning and expression of the ataxia-telangiectasia gene in baculovirus

Scott, SP, Zhang, N, Khanna, KK, Khromykh, A, Hobson, K, Watters, D and Lavin, MF (1998). Cloning and expression of the ataxia-telangiectasia gene in baculovirus. Biochemical and Biophysical Research Communications, 245 (1), 144-148. doi: 10.1006/bbrc.1998.8137

ATM associates with and phosphorylates p53: Mapping the region of interaction

Khanna K.K., Keating K.E., Kozlov S., Scott S., Gatei M., Hobson K., Taya Y., Gabrielli B., Chan D., Lees-Miller S.P. and Lavin M.F. (1998). ATM associates with and phosphorylates p53: Mapping the region of interaction. Nature Genetics, 20 (4), 398-400. doi: 10.1038/3882

Interaction between ATM protein and c-Abl in response to DNA damage

Shafman, T, Khanna, KK, Kedar, P, Spring, K, Kozlov, S, Yen, T, Hobson, K, Gatei, M, Zhang, N, Watters, D, Egerton, M, Shiloh, Y, Kharbanda, S, Kufe, D and Lavin, MF (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature, 387 (6632), 520-523. doi: 10.1038/387520a0

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

Watters, D, Khanna, KK, Beamish, H, Birrell, G, Spring, K, Kedar, P, Gatei, M, Stenzel, D, Hobson, K, Kozlov, S, Zhang, N, Farrell, A, Ramsay, J, Gatti, R and Lavin, M (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene, 14 (16), 1911-1921. doi: 10.1038/sj.onc.1201037

Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells

Khanna, KK, Yan, J, Watters, D, Hobson, K, Beamish, H, Spring, K, Shiloh, Y, Gatti, RA and Lavin, MF (1997). Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells. Journal of Biological Chemistry, 272 (14), 9489-9495. doi: 10.1074/jbc.272.14.9489

Isolation of full-length ATM cDNA and correction of the ataxia- telangiectasia cellular phenotype

Zhang, N, Chen, P, Khanna, KK, Scott, S, Gatei, M, Kozlov, S, Watters, D, Spring, K, Yen, T and Lavin, MF (1997). Isolation of full-length ATM cDNA and correction of the ataxia- telangiectasia cellular phenotype. Proceedings of the National Academy of Sciences of the United States of America, 94 (15), 8021-8026. doi: 10.1073/pnas.94.15.8021

Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation

Yan, J, Khanna, KK and Lavin, MF (1996). Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. International Journal of Radiation Biology, 69 (5), 539-546. doi: 10.1080/095530096145544

Genetic complementation of radiation response by 3′ untranslated regions (UTR) of RNA

Chen, P., Girjes, A. A., Hobson, K., Beamish, H., Khanna, K. K., Farrell, A., Gatei, M., Teale, B., Buchwald, M., Legerski, R. and Lavin, M. F. (1996). Genetic complementation of radiation response by 3′ untranslated regions (UTR) of RNA. International Journal of Radiation Biology, 69 (3), 385-395. doi: 10.1080/095530096145940

Nature of G1/s cell-cycle checkpoint defect in ataxia-telangiectasia

Khanna, KK, Beamish, H, Yan, J, Hobson, K, Williams, R, Dunn, I and Lavin, MF (1995). Nature of G1/s cell-cycle checkpoint defect in ataxia-telangiectasia. Oncogene, 11 (4), 609-618.

Understanding the role of Cep55 in initiation and progression of cancers

Rashidieh, Behnam, Tria, Simon M. and Khanna, Kum Kum (2022). Understanding the role of Cep55 in initiation and progression of cancers. AACR Annual Meeting 2022, New Orleans, LA United States, 8-13 April 2022. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2022-6033

Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer

Raninga, P., Lee, A., Sinha, D., Shin, Y-Y., Mittal, D., Kalimutho, M. and Khanna, K. K. (2019). Synergistic anti-cancer activity of auranofin with anti-PD-L1 therapy in triple negative breast cancer. 44th Congress of the European-Society-for-Medical-Oncology (ESMO), Barcelona, Spain, 27 September - 1 October 2019. Oxford, United Kingdom: Oxford University Press.

CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo

Sinha, D., Kalimutho, M., Bain, A.L. and Khanna, K.K. (2018). CEP55 over-expression causes genomic instability to initiate spontaneous tumour formation in vivo. 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, Netherlands, 30 June – 3 July 2018. London, United Kingdom: Elsevier. doi: 10.1136/esmoopen-2018-eacr25.730

Synergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer

Sinha, D., Kalimutho, M., Lopez, A. J. and Khanna, K. K. (2017). Synergistic inhibition of CEP55 induces mitotic catastrophe and specifically targets aggressive breast cancer. 42nd European-Society-for-Medical-Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: OXFORD UNIV.

Targeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer

Raninga, P., Kalimutho, M., Sinha, D., Bain, A., Tonissen, K. and Khanna, K. K. (2017). Targeting thioredoxin reductase 1 in novel combination therapies in p53 mutant triple negative breast cancer. 42nd European Society for Medical Oncology Congress (ESMO), Madrid, Spain, 8-12 September 2017. Oxford, United Kingdom: Oxford University Press.

SSB1 AND SSB2 SINGLE-STRANDED DNA BINDING PROTEINS ARE ESSENTIAL FOR HSC FUNCTION

Vu, Therese, Shi, Wei, Lane, Steven and Khanna, Kum Kum (2015). SSB1 AND SSB2 SINGLE-STRANDED DNA BINDING PROTEINS ARE ESSENTIAL FOR HSC FUNCTION. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto Japan, Sep 17-19, 2015. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.exphem.2015.06.274

The adaptor protein ASC controls transplantation outcomes independently of the inflammasome

Cheong, Melody, Gartlan, Kate, Tey, Siok-Keen, Kuns, Rachel, Lor, Mary, Lineburg, Katie, Tea, Bianca, Shi, Wei, Raju, Jyothy, Zhang, Ping, Varelias, Antiopi, Leveque-El Mouttie, Lucie, Olver, Stuart, Bunting, Mark, Lane, Steven, Boyle, Glen, Ting, Jenny, Schroder, Kate, Engwerda, Christian, Khanna, Kum Kum, Smyth, Mark, MacDonald, Kelli, Koyama, Motoko and Hill, Geoffrey (2015). The adaptor protein ASC controls transplantation outcomes independently of the inflammasome. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Genomic and transcriptomic landscapes of human brain metastases

Saunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

SSB1 is essential for embryogenesis and maintenance of genomic stability in mice

Khanna, KumKum, Shi, Wei and Bain, Amanda (2012). SSB1 is essential for embryogenesis and maintenance of genomic stability in mice. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2012-2127

Role of HER3 in brain metastases from primary breast cancer

Saunus, Jodi M., Da Silva, Leonard, Momeny, Majid, Morrison, Brian, Lane, Annette, Smart, Chanel, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2012). Role of HER3 in brain metastases from primary breast cancer. 24th Lorne Cancer Conference, Lorne, VIC, Australia, 9-12 February 2012.

Uncovering molecular mechanisms involved in metastasis to the brain

Saunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Vargas, Ana Cristina, Al-Ejeh, Fares, Morrison, Brian, Khanna, Kum Kum, Grimmond, Sean, Chenevix-Trench, Georgia, Jeffree, Rosalind L., Waddell, Nicola, Simpson, Peter T. and Lakhani, Sunil R. (2012). Uncovering molecular mechanisms involved in metastasis to the brain. 14th International Biennial Congress of the Metastasis Research Society, Brisbane, QLD, Australia, 2-5 September 2012.

DNA damage response

Khanna, K.K. and Tibbetts, R. (2003). DNA damage response.