The University of Queensland

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model

Dark, Callum, Ali, Nashia, Golenkina, Sofya, Dhyani, Vaibhav, Blazev, Ronnie, Parker, Benjamin L, Murphy, Kate T, Lynch, Gordon S, Senapati, Tarosi, Millard, S Sean, Judge, Sarah M, Judge, Andrew R, Giri, Lopamudra, Russell, Sarah M and Cheng, Louise Y (2024). Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model. EMBO Reports, 1-24. doi: 10.1038/s44319-024-00102-z

FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC

Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M. and Ng, Dominic C.H. (2020). Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. Biochimica et Biophysica Acta - Molecular Cell Research, 1867 (7) 118713, 118713. doi: 10.1016/j.bbamcr.2020.118713

Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway

Odierna, G. Lorenzo, Kerwin, Sarah K., Harris, Lucy E., Shin, Grace Ji-eun, Lavidis, Nickolas A., Noakes, Peter G. and Millard, S. Sean (2020). Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway. Journal of Cell Biology, 219 (6) e201909143. doi: 10.1083/jcb.201909143

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development

Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y., Parton, Robert G., Millard, Sean S., Xu, Zhiheng, Piper, Michael and Ng, Dominic C. H. (2020). The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Human Molecular Genetics, 29 (2), 248-263. doi: 10.1093/hmg/ddz281

Deterministic splicing of Dscam2 is regulated by Muscleblind

Li, Joshua Shing Shun and Sean Millard, S. (2019). Deterministic splicing of Dscam2 is regulated by Muscleblind. Science Advances, 5 (1) eaav1678, eaav1678. doi: 10.1126/sciadv.aav1678

Strategies for assembling columns and layers in the Drosophila visual system

Millard, S. Sean and Pecot, Matthew Y. (2018). Strategies for assembling columns and layers in the Drosophila visual system. Neural Development, 13 (1) 11, 11. doi: 10.1186/s13064-018-0106-9

Regulated alternative splicing of Drosophila Dscam2 is necessary for attaining the appropriate number of photoreceptor synapses

Kerwin, Sarah K., Li, Joshua Shing Shun, Noakes, Peter G., Shin, Grace Ji-eun and Millard, S. Sean (2018). Regulated alternative splicing of Drosophila Dscam2 is necessary for attaining the appropriate number of photoreceptor synapses. Genetics, 208 (2), 717-728. doi: 10.1534/genetics.117.300432

Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth

Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C. H. and Quinn, Leonie M. (2017). Glial-specific functions of microcephaly protein WDR62 and interaction with the mitotic kinase AURKA are essential for Drosophila brain growth. Stem Cell Reports, 9 (1), 32-41. doi: 10.1016/j.stemcr.2017.05.015

Dscam proteins direct dendritic targeting through adhesion

Tadros, Wael, Xu, Shuwa, Akin, Orkun, Yi, Caroline H., Shin, Grace Ji-eun, Millard, S. Sean and Zipursky, S. Lawrence (2016). Dscam proteins direct dendritic targeting through adhesion. Neuron, 89 (3), 480-493. doi: 10.1016/j.neuron.2015.12.026

Dscam2 affects visual perception in Drosophila melanogaster

Bosch, Danny S., van Swinderen, Bruno and Millard, S. Sean (2015). Dscam2 affects visual perception in Drosophila melanogaster. Frontiers in Behavioral Neuroscience, 9 (June) A149, 1-13. doi: 10.3389/fnbeh.2015.00149

Neuronal cell-type-specific alternative splicing: A mechanism for specifying connections in the brain?

Li, Joshua Shing Shun, Shin, Grace Ji-eun and Millard, Sean S. (2015). Neuronal cell-type-specific alternative splicing: A mechanism for specifying connections in the brain?. Neurogenesis, 2 (1), e1122699.1-e1122699.5. doi: 10.1080/23262133.2015.1122699

Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring

Lah, Grace Ji-eun, Li, Joshua Shing Shun and Millard, S. Sean (2014). Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring. Neuron, 83 (6), 1376-1388. doi: 10.1016/j.neuron.2014.08.002

Combinatorial rules of precursor specification underlying olfactory neuron diversity

Li, Qingyun, Ha, Tal Soo, Okuwa, Sumie, Wang, Yiping, Wang, Qian, Millard, S. Sean, Smith, Dean P. and Volkan, Pelin Cayirlioglu (2013). Combinatorial rules of precursor specification underlying olfactory neuron diversity. Current Biology, 23 (24), 2481-2490. doi: 10.1016/j.cub.2013.10.053

Vision in Drosophila: seeing the world through a model's eyes

Paulk, Angelique, Millard, S. Sean and van Swinderen, Bruno (2013). Vision in Drosophila: seeing the world through a model's eyes. Annual Review of Entomology, 58 (1), 313-332. doi: 10.1146/annurev-ento-120811-153715

Drosophila Dscam proteins regulate postsynaptic specificity at multiple-contact synapses

Millard, S. Sean, Lu, Zhiyuan, Zipursky, S. Lawrence and Meinertzhagen, Ian A. (2010). Drosophila Dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Neuron, 67 (5), 761-768. doi: 10.1016/j.neuron.2010.08.030

Dscam-mediated cell recognition regulates neural circuit formation

Hattori, D., Millard, S. S., Wojtowicz, W. M. and Zipursky, S. L. (2008). Dscam-mediated cell recognition regulates neural circuit formation. Annual Review of Cell And Developmental Biology, 24 (1), 597-620. doi: 10.1146/annurev.cellbio.24.110707.175250

Dscam-mediated repulsion controls tiling and self-avoidance

Millard, S. Sean and Zipursky, S. Lawrence (2008). Dscam-mediated repulsion controls tiling and self-avoidance. Current Opinion In Neurobiology, 18 (1), 84-89. doi: 10.1016/j.conb.2008.05.005

Dscam2 mediates axonal tiling in the Drosophila visual system

Millard, S. S., Flanagan, J. J., Pappu, K. S., Wu, W. and Zipursky, S. L. (2007). Dscam2 mediates axonal tiling in the Drosophila visual system. Nature, 447 (7145), 720-724. doi: 10.1038/nature05855

Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding

Wojtowicza, Woj M., Flanagan, John J., Millard, S. Sean, Zipursky, S.Lawrence and Clemens, James C. (2004). Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell, 118 (5), 619-633. doi: 10.1016/j.cell.2004.08.021

Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status

Vidal, Anxo, Millard, S. Sean, Miller, Jeffrey P. and Koff, Andrew (2002). Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status. Journal of Biological Chemistry, 277 (19), 16433-16440. doi: 10.1074/jbc.M112090200

A U-rich element in the 5′ untranslated region is necessary for the translation of p27 mRNA

Millard, S. Sean, Vidal, Anxo, Markus, Maurice and Koff, Andrew (2000). A U-rich element in the 5′ untranslated region is necessary for the translation of p27 mRNA. Molecular and Cellular Biology, 20 (16), 5947-5959. doi: 10.1128/MCB.20.16.5947-5959.2000

Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

Cordon-Cardo, Carlos, Koff, Andrew, Drobnjak, Marija, Capodieci, Paola, Osman, Iman, Millard, S. Sean, Gaudin, Paul B., Fazzari, Melissa, Zhang, Zuo-Feng, Massague, Joan and Scher, Howard I. (1998). Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. JNCI: Journal of the National Cancer Institute, 90 (17), 1284-1291. doi: 10.1093/jnci/90.17.1284

A naturally occurring mutation in FcyRIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor

Norris, Cynthia F., Pricop, Luminita, Millard, Sean S., Taylor, Scott M., Surrey, Saul, Schwartz, Elias, Salmon, Jane E. and McKenzie, Steven E. (1998). A naturally occurring mutation in FcyRIIA: a Q to K127 change confers unique IgG binding properties to the R131 allelic form of the receptor. Blood, 91 (2), 656-662.

Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis

Millard, S. S. and Koff, A. (1998). Cyclin-dependent kinase inhibitors in restriction point control, genomic stability, and tumorigenesis. Journal of Cellular Biochemistry. Supplement, 30/31, 37-42.

Enhanced ribosomal association of p27Kip1 mRNA is a mechanism contributing to accumulation during growth arrest

Millard, S. Sean, Yan, Jie Shi, Nguyen, Hoang, Pagano, Michele, Kiyokawa, Hiroaki and Koff, Andrew (1997). Enhanced ribosomal association of p27Kip1 mRNA is a mechanism contributing to accumulation during growth arrest. Journal of Biological Chemistry, 272 (11), 7093-7098. doi: 10.1074/jbc.272.11.7093

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans

Salmon, Jane E., Millard, Sean, Schachter, Leah A., Arnett, Frank C., Ginzler, Ellen M., Gourley, Mark F., Ramsey-Goldman, Rosalind, Peterson, Margaret G.E. and Kimberly, Robert P. (1996). Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. Journal of Clinical Investigation, 97 (5), 1348-1354. doi: 10.1172/JCI118552

Fc gamma receptor IIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner

Salmon, Jane E., Millard, Sean S., Brogle, Nina L. and Kimberly, Robert P. (1995). Fc gamma receptor IIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner. Journal of Clinical Investigation, 95 (6), 2877-2885. doi: 10.1172/JCI117994