The University of Queensland

Genetic and immunohistochemistry tools to visualize rat macrophages in situ

Huang, Stephen, Carter-Cusack, Dylan, Maxwell, Emma, Patkar, Omkar L., Irvine, Katharine M. and Hume, David A. (2024). Genetic and immunohistochemistry tools to visualize rat macrophages in situ. Tissue-resident macrophages: methods and protocols. (pp. 99-115) edited by Elvira Mass. New York, United States: Humana Press. doi: 10.1007/978-1-0716-3437-0_6

The impact of CAGE data on understanding macrophage transcriptional biology

Hume, David A., Schroder, Kate and Irvine, Katharine M. (2009). The impact of CAGE data on understanding macrophage transcriptional biology. Cap-Analysis Gene Expression (CAGE): The Science of Decoding Genes Transcription. (pp. 227-243) Pan Stanford Publishing Pte. Ltd.. doi: 10.4032/9789814241359

The impact of CAGE data on the understanding of macrophage transcriptional biology

Hume, D. A., Irvine, K. M. and Schroder, K. (2009). The impact of CAGE data on the understanding of macrophage transcriptional biology. Cap- Analysis Gene Expression (Cage): The Science of Decoding Gene Transcription. (pp. 227-244) edited by Piero Carninci. Singapore: Pan Stanford Publishing.

Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine M, Ho, Eileen, Caruso, Melanie, Patkar, Omkar L, Sehgal, Anuj, Millard, Susan M, Hume, David A and Pettit, Allison R (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology. doi: 10.1093/jleuko/qiae077

A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria

Nhu, Nguyen Thi Khanh, Rahman, M. Arifur, Goh, Kelvin G. K., Kim, Seung Jae, Phan, Minh-Duy, Peters, Kate M., Alvarez-Fraga, Laura, Hancock, Steven J., Ravi, Chitra, Kidd, Timothy J., Sullivan, Matthew J., Irvine, Katharine M., Beatson, Scott A., Sweet, Matthew J., Irwin, Adam D., Vukovic, Jana, Ulett, Glen C., Hasnain, Sumaira Z. and Schembri, Mark A. (2024). A convergent evolutionary pathway attenuating cellulose production drives enhanced virulence of some bacteria. Nature Communications, 15 (1) 1441, 1441. doi: 10.1038/s41467-024-45176-4

Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism

Keshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023

Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists

Gracen, Lucy, Muthukumara, Withma, Aikebuse, Melanie, Russell, Anthony, O'Beirne, James, Irvine, Katharine M., Williams, Suzanne, Puri, Gaurav, Valery, Patricia C., Hayward, Kelly L. and Powell, Elizabeth E. (2023). Lower prevalence of elevated liver stiffness measurements in people with type 2 diabetes taking sodium-glucose co-transporter 2 inhibitors or glucagon-like peptide-1 receptor agonists. Annals of Hepatology, 28 (6) 101142, 101142. doi: 10.1016/j.aohep.2023.101142

Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development

Hume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052

Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis

Sehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Thai, Le May, O'Reilly, Liam, Reibe-Pal, Saskia, Sue, Nancy, Holliday, Holly, Small, Lewin, Schmitz-Peiffer, Carsten, Dhenni, Rama, Wang-Wei Tsai, Vicky, Norris, Nicholas, Yau, Belinda, Zhang, Xuan, Lee, Kailun, Yan, Chenxu, Shi, Yan-Chuan, Kebede, Melkam A., Brink, Robert, Cooney, Gregory J., Irvine, Katharine M., Breit, Samuel N., Phan, Tri G., Swarbrick, Alexander and Biden, Trevor J. (2023). β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling. iScience, 26 (4) 106477, 1-23. doi: 10.1016/j.isci.2023.106477

Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)

Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784

Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes

Gracen, Lucy, Hayward, Kelly L., Aikebuse, Melanie, Russell, Anthony, O’Beirne, James, McPhail, Steven, Irvine, Katharine M., Williams, Suzanne, Valery, Patricia C. and Powell, Elizabeth E. (2022). Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes. BMC Health Services Research, 22 (1) 487, 1-11. doi: 10.1186/s12913-022-07808-7

CSF1R as a therapeutic target in bone diseases: obvious but not so simple

Hume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4

Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD

Canivet, Clémence M., Costentin, Charlotte, Irvine, Katharina M., Delamarre, Adèle, Lannes, Adrien, Sturm, Nathalie, Oberti, Frederic, Patel, Preya J., Decaens, Thomas, Irles-Depé, Marie, Fouchard, Isabelle, Hermabessière, Paul, Roux, Marine, Barthelon, Justine, Calès, Paul, Powell, Elizabeth E., de Ledinghen, Victor and Boursier, Jérôme (2022). Validation of the new 2021 EASL algorithm for the noninvasive diagnosis of advanced fibrosis in NAFLD. Hepatology, 77 (3), n/a-n/a. doi: 10.1002/hep.32665

Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis

Gracen, Lucy, Hayward, Kelly L., Irvine, Katharine M., Valery, Patricia C. and Powell, Elizabeth E. (2022). Low accuracy of FIB-4 test to identify people with diabetes at low risk of advanced fibrosis. Journal of Hepatology, 77 (4), 1219-1221. doi: 10.1016/j.jhep.2022.06.016

Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study

Ratnasekera, Isanka U., Johnson, Amy, Powell, Elizabeth E., Henderson, Andrew, Irvine, Katharine M. and Valery, Patricia C. (2022). Epidemiology of ascites fluid infections in patients with cirrhosis in Queensland, Australia from 2008 to 2017: a population-based study. Medicine, 101 (20) 00010, e29217. doi: 10.1097/MD.0000000000029217

Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis

Hayward, Kelly L., Bansal, Vikas, Valery, Patricia C., Irvine, Katharine M., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2022). Patient‐oriented medication education intervention has long‐term benefits for people with decompensated cirrhosis. Hepatology Communications, 6 (11), 3281-3282. doi: 10.1002/hep4.1999

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling

Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166

Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism

Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

Nalkurthi, Christina, Schroder, Wayne A., Melino, Michelle, Irvine, Katharine M., Nyuydzefe, Melanie, Chen, Wei, Liu, Jing, Teng, Michele WL., Hill, Geoffrey R., Bertolino, Patrick, Blazar, Bruce R., Miller, Gregory C., Clouston, Andrew D., Zanin-Zhorov, Alexandra and MacDonald, Kelli PA. (2022). ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis. JHEP Reports, 4 (1) 100386, 100386. doi: 10.1016/j.jhepr.2021.100386

Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease

Keshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387

Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study

Johnson, Amy L., Ratnasekera, Isanka U., Irvine, Katharine M., Henderson, Andrew, Powell, Elizabeth E. and Valery, Patricia C. (2021). Bacteraemia, sepsis and antibiotic resistance in Australian patients with cirrhosis: a population-based study. BMJ Open Gastroenterology, 8 (1) e000695. doi: 10.1136/bmjgast-2021-000695

A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

Patkar, Omkar L., Mohamed, Abdalla Z., Narayanan, Ashwin, Mardon, Karine, Cowin, Gary, Bhalla, Rajiv, Stimson, Damion H. R., Kassiou, Michael, Beecher, Kate, Belmer, Arnauld, Alvarez Cooper, Ignatius, Morgan, Michael, Hume, David A., Irvine, Katharine M., Bartlett, Selena E., Nasrallah, Fatima and Cumming, Paul (2021). A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Scientific Reports, 11 (1) 11252, 11252. doi: 10.1038/s41598-021-90817-z

Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease

Irvine, Katharine M., Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Williams, Suzanne, Russell, Anthony and Powell, Elizabeth E. (2021). Serum matrix metalloproteinase 7 (MMP7) is a biomarker of fibrosis in patients with non-alcoholic fatty liver disease. Scientific Reports, 11 (1) 2858, 1-8. doi: 10.1038/s41598-021-82315-z

Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058

Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety

Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Li, Catherine, Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2021). Medication discrepancies and regimen complexity in decompensated cirrhosis: implications for medication safety. Pharmaceuticals, 14 (12) 1207. doi: 10.3390/ph14121207

Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests

Johnson, Amy L., Hayward, Kelly L., Patel, Preya, Horsfall, Leigh U., Cheah, Alvin Ee Zhiun, Irvine, Katharine M., Russell, Anthony W., Stuart, Katherine A., Williams, Sue, Hartel, Gunter, Valery, Patricia C. and Powell, Elizabeth E. (2021). Predicting liver‐related outcomes in people with nonalcoholic fatty liver disease: the prognostic value of noninvasive fibrosis tests. Hepatology Communications, 6 (4), 728-739. doi: 10.1002/hep4.1852

Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair

Sehgal, Anuj, Irvine, Katharine M. and Hume, David A. (2021). Functions of macrophage colony-stimulating factor (CSF1) in development, homeostasis, and tissue repair. Seminars in Immunology, 54 101509, 101509. doi: 10.1016/j.smim.2021.101509

Osteal macrophages support osteoclast‐mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model

Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Wu, Andy C., Kaur, Simranpreet, Sun, Lucas W.H., Williams, Kyle, Sandrock, Cheyenne, Ng, Pei Ying, Irvine, Katharine M., Bartnikowski, Michal, Glatt, Vaida, Pavlos, Nathan J. and Pettit, Allison R. (2021). Osteal macrophages support osteoclast‐mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model. Journal of Bone and Mineral Research, 36 (11), 2214-2228. doi: 10.1002/jbmr.4413

Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones

Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936

Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care

Hayward, Kelly L., McKillen, Benjamin J., Horsfall, Leigh U., McIvor, Carolyn, Liew, Katerina, Sexton, Jo, Johnson, Amy L., Irvine, Katharine M., Valery, Patricia C., McPhail, Steven M., Britton, Laurence J., Rosenberg, William, Weate, Ingrid, Williams, Sue and Powell, Elizabeth E. (2021). Towards collaborative management of nonalcoholic fatty liver disease ( TCM‐NAFLD ): a ‘real‐world’ pathway for fibrosis risk assessment in primary care. Internal Medicine Journal, 52 (10) imj.15422, 1749-1758. doi: 10.1111/imj.15422

CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

Keshvari, Sahar, Caruso, Melanie, Teakle, Ngari, Batoon, Lena, Sehgal, Anuj, Patkar, Omkar L., Ferrari-Cestari, Michelle, Snell, Cameron E., Chen, Chen, Stevenson, Alex, Davis, Felicity M., Bush, Stephen J., Pridans, Clare, Summers, Kim M., Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2021). CSF1R-dependent macrophages control postnatal somatic growth and organ maturation. PLoS Genetics, 17 (6) e1009605, e1009605. doi: 10.1371/journal.pgen.1009605

The mononuclear phagocyte system of the rat

Hume, David A., Caruso, Melanie, Keshvari, Sahar, Patkar, Omkar L., Sehgal, Anuj, Bush, Stephen J., Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2021). The mononuclear phagocyte system of the rat. The Journal of Immunology, 206 (10), 2251-2263. doi: 10.4049/jimmunol.2100136

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Patkar, Omkar L., Caruso, Melanie, Teakle, Ngari, Keshvari, Sahar, Bush, Stephen J., Pridans, Clare, Belmer, Arnauld, Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2021). Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations. Neurobiology of Disease, 151 105268, 105268. doi: 10.1016/j.nbd.2021.105268

Transcriptomic analysis of rat macrophages

Pridans, Clare, Irvine, Katharine M, Davis, Gemma M, Lefevre, Lucas, Bush, Stephen J and Hume, David A (2021). Transcriptomic analysis of rat macrophages. Frontiers in Immunology, 11 594594. doi: 10.3389/fimmu.2020.594594

A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system

Grabert, Kathleen, Sehgal, Anuj, Irvine, Katharine M., Wollscheid-Lengeling, Evi, Ozdemir, Derya D., Stables, Jennifer, Luke, Garry A., Ryan, Martin D., Adamson, Antony, Humphreys, Neil E., Sandrock, Cheyenne J., Rojo, Rocio, Verkasalo, Veera A., Mueller, Werner, Hohenstein, Peter, Pettit, Allison R., Pridans, Clare and Hume, David A. (2020). A transgenic line that reports CSF1R protein expression provides a definitive marker for the mouse mononuclear phagocyte system. Journal of Immunology, 205 (11), 3154-3166. doi: 10.4049/jimmunol.2000835

Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis

Hayward, Kelly L., Valery, Patricia C., Patel, Preya J., Horsfall, Leigh U., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., David, Michael, Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2020). Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis. Internal Medicine Journal, 50 (9), 1142-1146. doi: 10.1111/imj.14986

Longitudinal change in simple scores identifies fibrosis status in people with nonalcoholic fatty liver disease

McKillen, Benjamin J., Powell, Elizabeth E., Horsfall, Leigh U., Clouston, Andrew D., Brown, Nigel N., Elangovan, Harendran, Patel, Preya J., Valery, Patricia C., Irvine, Katharine M., Bernard, Anne and Hayward, Kelly L. (2020). Longitudinal change in simple scores identifies fibrosis status in people with nonalcoholic fatty liver disease. Journal of Clinical Gastroenterology, 54 (7), 661-662. doi: 10.1097/MCG.0000000000001372

Type 2 diabetes: a risk factor for hospital readmissions and mortality in Australian patients with cirrhosis

Ahn, Sang Bong, Powell, Elizabeth E., Russell, Anthony, Hartel, Gunter, Irvine, Katharine M., Moser, Chris and Valery, Patricia C. (2020). Type 2 diabetes: a risk factor for hospital readmissions and mortality in Australian patients with cirrhosis. Hepatology Communications, 4 (9) hep4.1536, 1279-1292. doi: 10.1002/hep4.1536

Hospitalisation for cirrhosis in Australia: disparities in presentation and outcomes for Indigenous Australians

Valery, Patricia C., Clark, Paul J., Pratt, Gregory, Bernardes, Christina M., Hartel, Gunter, Toombs, Maree, Irvine, Katharine M. and Powell, Elizabeth E. (2020). Hospitalisation for cirrhosis in Australia: disparities in presentation and outcomes for Indigenous Australians. International Journal for Equity in Health, 19 (1) 27, 27. doi: 10.1186/s12939-020-1144-6

Association between the fetal cerebroplacental ratio and biomarkers of hypoxia and angiogenesis in the maternal circulation at term

Irvine, Katharine M., Bligh, Larissa N. and Kumar, Sailesh (2019). Association between the fetal cerebroplacental ratio and biomarkers of hypoxia and angiogenesis in the maternal circulation at term. European Journal of Obstetrics and Gynecology and Reproductive Biology, 245, 198-204. doi: 10.1016/j.ejogrb.2019.11.018

Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene

Irvine, Katharine M., Caruso, Melanie, Cestari, Michelle Ferrari, Davis, Gemma M., Keshvari, Sahar, Sehgal, Anuj, Pridans, Clare and Hume, David A. (2019). Analysis of the impact of CSF‐1 administration in adult rats using a novel Csf1r ‐mApple reporter gene. Journal of Leukocyte Biology, 107 (2) JLB.MA0519-149R, 221-235. doi: 10.1002/jlb.ma0519-149r

Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores

Janubhai Patel, Preya, Chieh-Yu Cheng, Johnson, Banh, Xuan, Gracen, Lucy, Radford-Smith, Daniel, Hossain, Fabrina, Horsfall, Leigh Ula, Lee Hayward, Kelly, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine Anne, Russell, Anthony William, Valery, Patricia Casarolli, Clouston, Andrew Donald, Irvine, Katharine Margaret, Bernard, Anne and Powell, Elizabeth Ellen (2019). Clinically significant fibrosis is associated with longitudinal increases in fibrosis-4 and nonalcoholic fatty liver disease fibrosis scores. Clinical Gastroenterology and Hepatology, 18 (3), 710-718.e4. doi: 10.1016/j.cgh.2019.07.036

Phenotypic impacts of CSF1R deficiencies in humans and model organisms

Hume, David A., Caruso, Melanie, Ferrari‐Cestari, Michelle, Summers, Kim M., Pridans, Clare and Irvine, Katharine M. (2019). Phenotypic impacts of CSF1R deficiencies in humans and model organisms. Journal of Leukocyte Biology, 107 (2) JLB.MR0519-143R, 205-219. doi: 10.1002/jlb.mr0519-143r

Reply

Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Martin, Jennifer H. and Powell, Elizabeth E. (2019). Reply. Hepatology Communications, 3 (9), 1283-1284. doi: 10.1002/hep4.1398

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation

Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Gupta, Praveer K., Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2019). Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic Type 2 inflammation. British Journal of Pharmacology, 176 (19) bph.14768, 3775-3790. doi: 10.1111/bph.14768

Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells

Genz, Berit, Coleman, Miranda A., Irvine, Katharine M., Kutasovic, Jamie R., Miranda, Mariska, Gratte, Francis D., Tirnitz-Parker, Janina E. E., Olynyk, John. K., Calvopina, Diego A., Weis, Anna, Cloonan, Nicole, Robinson, Harley, Hill, Michelle M., Al-Ejeh, Fares and Ramm, Grant A. (2019). Overexpression of miRNA-25-3p inhibits Notch1 signaling and TGF-β-induced collagen expression in hepatic stellate cells. Scientific Reports, 9 (1) 8541, 8541. doi: 10.1038/s41598-019-44865-1

Medication‐related problems in outpatients with decompensated cirrhosis: Opportunities for harm prevention

Hayward, Kelly L., Patel, Preya J., Valery, Patricia C., Horsfall, Leigh U., Li, Catherine Y., Wright, Penny L., Tallis, Caroline J., Stuart, Katherine A., Irvine, Katharine M., Cottrell, W. Neil, Martin, Jennifer H. and Powell, Elizabeth E. (2019). Medication‐related problems in outpatients with decompensated cirrhosis: Opportunities for harm prevention. Hepatology Communications, 3 (5) hep4.1334, 620-631. doi: 10.1002/hep4.1334

Causes and consequences of innate immune dysfunction in cirrhosis

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Causes and consequences of innate immune dysfunction in cirrhosis. Frontiers in Immunology, 10 (FEB) 293, 293. doi: 10.3389/fimmu.2019.00293

The mononuclear phagocyte system: the relationship between monocytes and macrophages

Hume, David A., Irvine, Katharine M. and Pridans, Clare (2019). The mononuclear phagocyte system: the relationship between monocytes and macrophages. Trends in Immunology, 40 (2), 98-112. doi: 10.1016/j.it.2018.11.007

Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293)

Irvine, Katharine Margaret, Ratnasekera, Isanka, Powell, Elizabeth E. and Hume, David Arthur (2019). Corrigendum: Causes and consequences of innate immune dysfunction in cirrhosis (Frontiers in Immunology (2019) 10 (293) DOI: 10.3389/fimmu.2019.00293). Frontiers in Immunology, 10 (APR) 818, 818. doi: 10.3389/fimmu.2019.00818

ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages

Waddell, Lindsey A., Lefevre, Lucas, Bush, Stephen J., Raper, Anna, Young, Rachel, Lisowski, Zofia M., McCulloch, Mary E.B., Muriuki, Charity, Sauter, Kristin A., Clark, Emily L., Irvine, Katharine M., Pridans, Clare, Hope, Jayne C. and Hume, David A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in Immunology, 9 (OCT) 2246. doi: 10.3389/fimmu.2018.02246

A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care

Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Bernard, Anne, Brown, Nigel Neil, Lampe, Guy, Buck, Lyndall, Saad, Nivene, Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Rosenberg, William and Powell, Elizabeth Ellen (2018). A pragmatic approach identifies a high rate of nonalcoholic fatty liver disease with advanced fibrosis in diabetes clinics and at-risk populations in primary care. Hepatology Communications, 2 (8), 893-905. doi: 10.1002/hep4.1208

Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes

Ramnath, Divya, Irvine, Katharine M., Lukowski, Samuel W., Horsfall, Leigh U., Loh, Zhixuan, Clouston, Andrew D., Patel, Preya J., Fagan, Kevin J., Iyer, Abishek, Lampe, Guy, Stow, Jennifer L., Schroder, Kate, Fairlie, David P., Powell, Joseph E., Powell, Elizabeth E. and Sweet, Matthew J. (2018). Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight, 3 (14). doi: 10.1172/jci.insight.120274

Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control

Patel, Preya Janubhai, Hossain, Fabrina, Horsfall, Leigh Ula, Banh, Xuan, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Clouston, Andrew Donald, Stuart, Katherine Anne, Russell, Anthony William and Powell, Elizabeth Ellen (2018). Controlled attenuation parameter in NAFLD identifies risk of suboptimal glycaemic and metabolic control. Journal of Diabetes and its Complications, 32 (8), 799-804. doi: 10.1016/j.jdiacomp.2018.05.008

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats

Pridans, Clare, Sauter, Kristin A., Irvine, Katharine M., Davis, Gemma M., Lefevre, Lucas, Raper, Anna, Rojo, Rocio, Nirmal, Ajit J., Beard, Philippa, Cheeseman, Michael and Hume, David A. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American Journal of Physiology - Gastrointestinal and Liver Physiology, 314 (3), G388-G398. doi: 10.1152/ajpgi.00343.2017

Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis

Patel, Preya J., Banh, Xuan, Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew, Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C., Williams, Suzanne and Powell, Elizabeth E (2018). Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis. Internal Medicine Journal, 48 (2), 144-151. doi: 10.1111/imj.13667

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

Maradana, Muralidhara Rao, Yekollu, Suman Kumar, Zeng, Bijun, Ellis, Jonathan, Clouston, Andrew, Miller, Gregory, Talekar, Meghna, Bhuyan, Zaied Ahmed, Mahadevaiah, Sachin, Powell, Elizabeth E., Irvine, Katharine M., Thomas, Ranjeny and O'Sullivan, Brendan John (2018). Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism: Clinical and Experimental, 78, 80-94. doi: 10.1016/j.metabol.2017.09.002

Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease

Patel, Preya J., Smith, David, Connor, Jason P., Horsfall, Leigh U., Hayward, Kelly L., Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Stuart, Katherine A., Brown, Nigel N., Saad, Nivene, Clouston, Andrew D., Irvine, Katharine M., Russell, Anthony W., Valery, Patricia C. and Powell, Elizabeth E. (2017). Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology and Hepatology, 2017 7927685, 7927685-8. doi: 10.1155/2017/7927685

Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

Hayward, Kelly L., Valery, Patricia C., Martin, Jennifer H., Karmakar, Antara, Patel, Preya J., Horsfall, Leigh U., Tallis, Caroline J., Stuart, Katherine A., Wright, Penny L., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Cottrell, W. Neil (2017). Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis. World Journal of Gastroenterology, 23 (40), 7321-7331. doi: 10.3748/wjg.v23.i40.7321

Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management

Hayward, Kelly L., Horsfall, Leigh U., Ruffin, Brittany J., Cottrell, W. Neil, Chachay, Veronique S., Irvine, Katharine M., Martin, Jennifer H., Powell, Elizabeth E. and Valery, Patricia C. (2017). Optimising care of patients with chronic disease: patient-oriented education may improve disease knowledge and self-management. Internal Medicine Journal, 47 (8), 952-955. doi: 10.1111/imj.13505

Patient-oriented education and medication management intervention for people with decompensated cirrhosis: study protocol for a randomized controlled trial

Hayward, Kelly L., Martin, Jennifer H., Cottrell, W. Neil, Karmakar, Antara, Horsfall, Leigh U., Patel, Preya J., Smith, David D., Irvine, Katharine M., Powell, Elizabeth E. and Valery, Patricia C. (2017). Patient-oriented education and medication management intervention for people with decompensated cirrhosis: study protocol for a randomized controlled trial. Trials, 18 (1) 339, 339. doi: 10.1186/s13063-017-2075-4

Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management

Patel, Preya Janubhai, Hayward, Kelly Lee, Rudra, Rathiga, Horsfall, Leigh Ula, Hossain, Fabrina, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Clouston, Andrew Donald, Stuart, Katherine Anne, Valery, Patricia Casarolli, Irvine, Katharine Margaret, Russell, Anthony William and Powell, Elizabeth Ellen (2017). Multimorbidity and polypharmacy in diabetic patients with NAFLD: implications for disease severity and management. Medicine, 96 (26) e6761, e6761. doi: 10.1097/MD.0000000000006761

Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus

O'Leary, Caroline A., Sedhom, Mamdouh, Reeve-Johnson, Mia, Mallyon, John and Irvine, Katharine M. (2017). Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus. Veterinary Immunology and Immunopathology, 186, 1-8. doi: 10.1016/j.vetimm.2016.12.011

Identifying areas of need relative to liver disease: geographic clustering within a health service district

El-Atem, Nathan, Irvine, Katharine M., Valery, Patricia C., Wojcik, Kyle, Horsfall, Leigh, Johnson, Tracey, Janda, Monika, McPhail, Steven M. and Powell, Elizabeth E. (2017). Identifying areas of need relative to liver disease: geographic clustering within a health service district. Australian Health Review, 41 (4), 407-418. doi: 10.1071/AH15225

Multiplex serum protein analysis identifies novel biomarkers of advanced fibrosis in patients with chronic liver disease with the potential to improve diagnostic accuracy of established biomarkers

Irvine, Katharine M., Wockner, Leesa F., Hoffmann, Isabel, Horsfall, Leigh U., Fagan, Kevin J., Bijin, Veonice, Lee, Bernett, Clouston, Andrew D., Lampe, Guy, Connolly, John E. and Powell, Elizabeth E. (2016). Multiplex serum protein analysis identifies novel biomarkers of advanced fibrosis in patients with chronic liver disease with the potential to improve diagnostic accuracy of established biomarkers. PLoS ONE, 11 (11) 167001, e0167001. doi: 10.1371/journal.pone.0167001

Prevalence of medication discrepancies in patients with cirrhosis: A pilot study

Hayward, Kelly L., Valery, Patricia C., Cottrell, W. Neil, Irvine, Katharine M., Horsfall, Leigh U., Tallis, Caroline J., Chachay, Veronique S., Ruffin, Brittany J., Martin, Jennifer H. and Powell, Elizabeth E. (2016). Prevalence of medication discrepancies in patients with cirrhosis: A pilot study. BMC Gastroenterology, 16 (1) 114, 114. doi: 10.1186/s12876-016-0530-4

Altered peripheral blood monocyte phenotype and function in chronic liver disease: implications for hepatic recruitment and systemic inflammation

Gadd, Victoria L., Patel, Preya J., Jose, Sara, Horsfall, Leigh, Powell, Elizabeth E. and Irvine, Katharine M. (2016). Altered peripheral blood monocyte phenotype and function in chronic liver disease: implications for hepatic recruitment and systemic inflammation. PLoS One, 11 (6) e0157771, e0157771. doi: 10.1371/journal.pone.0157771

CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites

Irvine, Katharine M., Xuan Banh, Gadd, Victoria L., Wojcik, Kyle K., Ariffin, Juliana K., Jose, Sara, Lukowski, Samuel, Baillie, Gregory J., Sweet, Matthew J. and Powell, Elizabeth E. (2016). CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites. JCI Insight, 1 (8) e86914, e86914. doi: 10.1172/jci.insight.86914

Patterns of service utilisation within Australian hepatology clinics: high prevalence of advanced liver disease

El-Atem, N. A., Wojcik, K., Horsfall, L., Irvine, K. M., Johnson, T., McPhail, S. M. and Powell, E. E. (2016). Patterns of service utilisation within Australian hepatology clinics: high prevalence of advanced liver disease. Internal Medicine Journal, 46 (4), 420-426. doi: 10.1111/imj.13008

Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model

Melino, Michelle, Gadd, Victoria L., Alexander, Kylie A., Beattie, Lynette, Lineburg, Katie E., Martinez, Michelle, Teal, Bianca, Le Texier, Laetitia, Irvine, Katharine M., Miller, Gregory C., Boyle, Glen M., Hill, Geoffrey R., Clouston, Andrew D., Powel, Elizabeth E. and MacDonald, Kelli P. A. (2016). Spatiotemporal characterization of the cellular and molecular contributors to liver fibrosis in a murine hepatotoxic-injury model. American Journal of Pathology, 186 (3), 524-538. doi: 10.1016/j.ajpath.2015.10.029

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061

Can paracetamol (acetaminophen) be administered to patients with liver impairment?

Hayward, Kelly L., Powell, Elizabeth E., Irvine, Katharine M. and Martin, Jennifer H. (2015). Can paracetamol (acetaminophen) be administered to patients with liver impairment?. British Journal of Clinical Pharmacology, 81 (2), 210-222. doi: 10.1111/bcp.12802

Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7

Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes

Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17

The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease

Irvine, Katharine M., Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin J., Horsfall, Leigh U., Fletcher, Linda M., Ungerer, Jacobus P. J., Pretorius, Carel J., Miller, Gregory C., Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). The Enhanced liver fibrosis score is associated with clinical outcomes and disease progression in patients with chronic liver disease. Liver International, 36 (3), 370-377. doi: 10.1111/liv.12896

Response to ELF cut-off points: aetiology is also a relevant factor

Powell, Elizabeth E., Irvine, Katharine M., Fagan, Kevin J., Ballard, Emma and O'Rourke, Peter (2015). Response to ELF cut-off points: aetiology is also a relevant factor. Liver International, 35 (7), 1921-1921. doi: 10.1111/liv.12822

ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity

Fagan, Kevin J., Pretorius, Carel J., Horsfall, Leigh U., Irvine, Katharine M., Wilgen, Urs, Choi, Kihoon, Fletcher, Linda M., Tate, Jill, Melino, Michelle, Nusrat, Sharmin, Miller, Gregory C., Clouston, Andrew D., Ballard, Emma, O'Rourke, Peter, Lampe, Guy, Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2015). ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. Liver International, 35 (6), 1673-1681. doi: 10.1111/liv.12760

Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection

Fagan, Kevin J., Rogers, Geraint B., Melino, Michelle, Arthur, Dionne M., Costello, Mary-Ellen, Morrison, Mark, Powell, Elizabeth E. and Irvine, Katharine M. (2015). Ascites bacterial burden and immune cell profile are associated with poor clinical outcomes in the absence of overt infection. PLoS One, 10 (3) e0120642, e0120642. doi: 10.1371/journal.pone.0120642

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

Irvine, Katharine M., Skoien, Richard, Bokil, Nilesh J., Melino, Michelle, Thomas, Gethin P., Loo, Dorothy, Gabrielli, Brian, Hill, Michelle M., Sweet, Matthew J., Clouston, Andrew D. and Powell, Elizabeth E. (2014). Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration. World Journal of Gastroenterology, 20 (47), 17851-17862. doi: 10.3748/wjg.v20.i47.17851

Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?

Fagan, K. J., Zhao, Eileen Y., Horsfall, L. U., Ruffin, Brittany J., Kruger, Mark S., McPhail, S. M., O'Rourke, Peter, Ballard, Emma, Irvine, K. M. and Powell, E. E. (2014). Burden of decompensated cirrhosis and ascites on hospital services in a tertiary care facility: time for change?. Internal Medicine Journal, 44 (9), 865-872. doi: 10.1111/imj.12491

Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers

Fagan K.J., Irvine K.M., McWhinney B.C., Fletcher L.M., Horsfall L.U., Johnson L., O'Rourke P., Martin J., Scott I., Pretorius C.J., Ungerer J.P.J. and Powell E.E. (2014). Diagnostic sensitivity of carbohydrate deficient transferrin in heavy drinkers. BMC Gastroenterology, 14 (1) 97, 1-6. doi: 10.1186/1471-230X-14-97

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

Gadd, Victoria L., Skoien, Richard, Powell, Elizabeth E., Fagan, Kevin J., Winterford, Clay, Horsfall, Leigh, Irvine, Katharine and Clouston, Andrew D. (2014). The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology, 59 (4), 1393-1405. doi: 10.1002/hep.26937

New paradigms in the histopathology of NAFLD

Clouston, Andrew D., Gadd, Victoria L., Irvine, Katharine M. and Powell, Elizabeth E. (2014). New paradigms in the histopathology of NAFLD. Current Hepatitis Reports, 13 (2), 81-87. doi: 10.1007/s11901-014-0214-x

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959

Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention

Fagan, K. J., Irvine, K. M., Kumar, S., Bates, A., Horsfall, L. U., Feeney, G. F. and Powell, E. E. (2013). Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention. Internal Medicine Journal, 43 (10), 1096-1102. doi: 10.1111/imj.12229

BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin

Fagan, Kevin J., Irvine, Katharine M., McWhinney, Brett C., Fletcher, Linda M., Horsfall, Leigh U., Johnson, Lambro A., Clouston, Andrew D., Jonsson, Julie R., O'Rourke, Peter, Martin, Jennifer, Pretorius, Carel J., Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2013). BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin. Alcoholism Clinical and Experimental Research, 37 (10), 1771-1778. doi: 10.1111/acer.12143

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C

Gadd, Victoria L., Melino, Michelle, Roy, Sandrine, Horsfall, Leigh, O'Rourke, Peter, Williams, Millicent R., Irvine, Katharine M., Sweet, Matthew J., Jonsson, Julie R., Clouston, Andrew D. and Powell, Elizabeth E. (2013). Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver International, 33 (4), 569-579. doi: 10.1111/liv.12050

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020

Liver repercussions of defective gut surveillance

Irvine, Katharine M., Schroder, Elizabeth E. and Powell, Elizabeth E. (2012). Liver repercussions of defective gut surveillance. Hepatology, 56 (3), 1174-1177. doi: 10.1002/hep.25944

Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes

Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew and Thomas, Ranjeny (2012). Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes. Diabetes, 61 (5), 1281-1290. doi: 10.2337/db11-1549

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109

Histone deacetylases as regulators of inflammation and immunity

Shakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011). Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 (7), 335-343. doi: 10.1016/j.it.2011.04.001

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723

Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation

Kawaji, H, Severin, J, Lizio, M, Forrest, ARR, van Nimwegen, E, Rehli, M, Schroder, K, Irvine, K, Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, CO (2011). Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research, 39 (Supp. 1), D856-D860. doi: 10.1093/nar/gkq1112

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS

Halili, Maria A., Andrews, Melanie R., Labzin, Larisa I., Schroder, Kate, Matthias, Gabriele, Cao, Chun, Lovelace, Erica, Reid, Robert C., Le, Giang T., Hume, David A., Irvine, Katharine M., Matthias, Patrick, Fairlie, David P. and Sweet, Matthew J. (2010). Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology, 87 (6), 1103-1114. doi: 10.1189/jlb.0509363

Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009)

Taft, Ryan J., Glazov, Evgeny A., Cloonan, Nicole, Simons, Cas, Stephen, Stuart, Faulkner, Geoffrey J., Lassmann, Timo, Forrest, Alistair R. R., Grimmond, Sean M., Schroder, Kate, Irvine, Katharine, Arakawa, Takahiro, Nakamura, Mari, Kubosaki, Atsutaka, Hayashida, Kengo, Kawazu, Chika, Murata, Mitsuyoshi, Nishiyori, Hiromi, Fukuda, Shiro, Kawai, Jun, Daub, Carsten O., Hume, David A., Suzuki, Harukazu, Orlando, Valerio, Carninci, Piero, Hayashizaki, Yoshihide and Mattick, John S. (2009). Corrigendum: Tiny RNAs associated with transcription start sites in animals (vol 41, pg 572, 2009). Nature Genetics, 41 (7), 859-859. doi: 10.1038/ng0709-859a

Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling

Goh, Felicia, Irvine, Katharine M., Lovelace, Erica, Donnelly, Sheila, Jones, Malcolm K ., Brion, Kristian, Hume, David A., Kotze, Andrew C., Dalton John P., Ingham, Aaron and Sweet, Matthew J. (2009). Selective induction of the Notch ligand Jagged -1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology, 127 (3), 326-337. doi: 10.1111/j.1365-2567.2008.02979.x

The regulated retrotransposon transcriptome of mammalian cells

Faulkner, Geoffrey J., Kimura, Yasumasa, Daub, Carsten O., Wani, Shivangi, Plessy, Charles, Irvine, Katharine M., Schroder, Kate, Cloonan, Nicole, Steptoe, Anita L., Lassmann, Timo, Waki, Kazunori, Hornig, Nadine, Arakawa, Takahiro, Takahashi, Hazuki, Kawai, Jun, Forrest, Alistair R. R., Suzuki, Harukazu, Hayashizaki, Yoshihide, Hume, David A., Orlando, Valerio, Grimmond, Sean M. and Carninci, Piero (2009). The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics, 41 (5), 563-571. doi: 10.1038/ng.368

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

Suzuki, H, Forrest, ARR, van Nimwegen, E, Daub, CO, Balwierz, PJ, Irvine, KM, Lassmann, T, Ravasi, T, Hasegawa, Y, de Hoon, MJL, Katayama, S, Schroder, K, Carninci, P, Tomaru, Y, Kanamori-Katayama, M, Kubosaki, A, Akalin, A, Ando, Y, Arner, E, Asada, M, Asahara, H, Bailey, T, Bajic, VB, Bauer, D, Beckhouse, AG, Bertin, N, Bjorkegren, J, Brombacher, F, Bulger, E ... Riken Omics Science Center (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics, 41 (5), 553-562. doi: 10.1038/ng.375

Tiny RNAs associated with transcription start sites in animals

Taft, RJ, Glazov, EA, Cloonan, N, Simons, C, Stephen, S, Faulkner, GJ, Lassmann, T, Forrest, ARR, Grimmond, SM, Schroder, K, Irvine, K, Arakawa, T, Nakamura, M, Kubosaki, A, Hayashida, K, Kawazu, C, Murata, M, Nishiyori, H, Fukuda, S, Kawai, J, Daub, CO, Hume, DA, Suzuki, H, Orlando, V, Carninci, P, Hayashizaki, Y and Mattick, JS (2009). Tiny RNAs associated with transcription start sites in animals. Nature Genetics, 41 (5), 572-578. doi: 10.1038/ng.312

Data-driven normalization strategies for high-throughput quantitative RT-PCR

Mar, Jessica C., Kimura, Yasumasa, Schroder, Kate, Irvine, Katherine M., Hayashizaki, Yoshihide, Suzuki, Harukazu, Hume, David and Quackenbush, John (2009). Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics, 10 (1) 110, 110.1-110.10. doi: 10.1186/1471-2105-10-110

The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

Kawaji, H, Severin, J, Lizio, M, Waterhouse, A, Katayama, S, Irvine, K. M., Hume, D. A., Forrest, A. R. R., Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, C. O. (2009). The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Genome Biology, 10 (4) R40. doi: 10.1186/gb-2009-10-4-r40

Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez-Rojo, Manuel A., Schroder, Kate, Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Parton, Robert G., Hume, David A. and Sweet, Matthew J. (2009). Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology, 85 (2), 278-288. doi: 10.1189/jlb.0808497

Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer

Maeda, Norihiro, Nishiyori, Hiromi , Nakamura, Mari , Kawazu, Chika, Murata, Mitsuyoshi , Sano, Hiromi, Hayashida, Kengo, Fukuda, Shiro, Tagami, Michihira, Hasegawa, Akira, Murakami, Kayoko, Schroder, Kate, Irvine, Katharine, Hume, David A., Hayashizaki, Yoshihide, Carninci, Piero and Suzuki, Harukazu (2008). Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. BioTechniques, 45 (1), 95-97. doi: 10.2144/000112814

Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages

Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K. A., Irvine, K. M., Burrows, A. D., Ravasi, T., Weighardt, H., Stacey, K. J., Decker, T., Hume, D. A., Dalpke, A. H. and Sweet, M. J. (2007). Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: Alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology, 179 (6), 3495-3503. doi: 10.4049/jimmunol.179.6.3495

PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages

Schroder, Kate, Lichtinger, Monika, Irvine, Katharine M., Brion, Kristian, Trieu, Angela, Ross, Ian L., Ravasi, Timothy, Stacey, Katryn J., Rehli, Michael, Hume, David A. and Sweet, Matthew J. (2007). PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology, 81 (6), 1577-1590. doi: 10.1189/jlb.0107036

Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses

Ripoll, Vera M., Irvine, Katharine M., Ravasi, Timothy, Sweet, Matthew J. and Hume, David A. (2007). Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. Journal of Immunology, 178 (10), 6557-6566. doi: 10.4049/jimmunol.178.10.6557

A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2006). A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. The FASEB Journal, 20 (11), 1921-1923. doi: 10.1096/fj.06-5848fje

Rasputin, more promiscuous than ever: a review of G3BP

Irvine, K., Stirling, R., Hume, D. and Kennedy, D. (2004). Rasputin, more promiscuous than ever: a review of G3BP. International Journal of Developmental Biology, 48 (10), 1065-1077. doi: 10.1387/ijdb.041893ki

Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer

Batoon, Lena, Keshvari, Sahar, Irvine, Katharine, Caruso, Melanie, Patkar, Omkar, Sehgal, Anuj, Millard, Susan, Hume, David and Pettit, Allison (2023). Mechanisms underlying the rescue of postnatal bone development in CSF1R-deficient rats following wild-type bone marrow cell transfer. 2022 Annual Meeting of the American Society for Bone and Mineral Research, Austin, TX, United States, 9-12 September 2022. Hoboken, NJ, United States: Wiley-Blackwell.

Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation

Iyer, Abishek, Loh, Zhixuan, Fitzsimmons, Rebecca L., Reid, Robert C., Ramnath, Divya, Clouston, Andrew, Irvine, Katharine M., Powell, Elizabeth E., Schroder, Kate, Stow, Jennifer L., Sweet, Matthew J. and Fairlie, David P. (2019). Histone Deacetylase Inhibitors Attenuate Hepatic Fibrosis through Suppression of Group 2 Innate Lymphoid Cells and Type 2 Inflammation. Experimental Biology Meeting (EB), Orlando Fl, Apr 06-09, 2019. HOBOKEN: WILEY.

Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice

Irvine, Katharine, Genz, Berit, Clouston, Andrew D. and Hume, David (2018). Macrophage colony stimulating factor (CSF1) promotes regression of advanced fibrosis and liver regeneration in mice. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, San Francisco, CA USA, 9-13 November 2018. Hoboken, NJ USA: Wiley.

Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores

Patel, Preya, Cheng, Johnson Chieh-Yu, Banh, Xuan, Hossain, Fabrina, Horsfall, Leigh Ula, Hayward, Kelly Lee, Williams, Suzanne, Johnson, Tracey, Brown, Nigel Neil, Saad, Nivene, Stuart, Katherine A., Russell, Anthony William, Valery, Patricia Casarolli, Irvine, Katharine, Clouston, Andrew D., Bernard, Anne and Powell, Elizabeth E. (2018). Advanced fibrosis is associated with longitudinal increases in Fibrosis-4 and NAFLD fibrosis scores. Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, San Francisco, CA United States, 9-13 November 2018. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/hep.30257

RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease

Ramnath, D., Irvine, K., Lukowski, S., Horsfall, L., Loh, K., Clouston, A., Patel, P., Iyer, A., Lampe, G., Stow, J., Schroder, K., Fairlie, D., Powell, J., Powell, E. and Sweet, M. (2018). RNA-sequencing analysis of biopsies from chronic liver disease patients identifies gene signatures associated with progressive liver disease. International Liver Congress (ILC), Paris, France, 11-15 April, 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(18)31040-7

Can modest alcohol intake be dismissed as a co-factor in diabetic patients with non-alcoholic fatty liver disease?

Patel, P. J., Smith, D. D., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N. N., Saad, N., Clouston, A. D., Irvine, K. M., Russell, A. W., Valery, P. C. and Powell, E. E. (2017). Can modest alcohol intake be dismissed as a co-factor in diabetic patients with non-alcoholic fatty liver disease?. International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Amsterdam, Netherlands, 19-23 April 2017. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(17)31602-1

Enhanced Liver Fibrosis test and liver stiffness measurements identify high prevalence of advanced fibrosis in people with type 2 diabetes

Patel, P. J., Stuart, K. A., Horsfall, L. U., Hayward, K. L., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Saad, N., Clouston, A., Irvine, K. M., Russell, A., Valery, P. C. and Powell, E. E. (2017). Enhanced Liver Fibrosis test and liver stiffness measurements identify high prevalence of advanced fibrosis in people with type 2 diabetes. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20 - 22 August 2017. Richmond, VIC Australia: Wiley-Blackwell.

High-risk medication-related problems are prevalent in people with decompensated cirrhosis

Hayward, K. L., Patel, P. J., Valery, P. C., Horsfall, L. U., Li, C. Y., Wright, P. L., Tallis, C. J., Stuart, K. A., Irvine, K. M., Cottrell, W. N., Powell, E. E. and Martin, J. H. (2017). High-risk medication-related problems are prevalent in people with decompensated cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD, Australia, 20 - 22 August 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.

Medication beliefs predict low medication adherence in people with decompensated cirrhosis

Hayward, K. L., Valery, P. C., Martin, J. H., Karmakar, A., Patel, P. J., Horsfall, L. U., Irvine, K. M., Stuart, K. A., Tallis, C. J., Wright, P. L., Smith, D. D., Powell, E. E. and Cottrell, W. N. (2017). Medication beliefs predict low medication adherence in people with decompensated cirrhosis. International Liver Congress / 52nd Annual Meeting of the European Association for the Study of the Liver, Amsterdam, The Netherlands, 19 - 23 April 2017. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(17)31113-3

Medication adherence in outpatients with decompensated cirrhosis

Hayward, K. L., Cottrell, W. N., Karmakar, A., Patel, P. J., Horsfall, L. U., Martin, J. H., Irvine, K. M., Tallis, C. J., Wright, P. L., Stuart, K. A., Valery, P. C. and Powell, E. E. (2016). Medication adherence in outpatients with decompensated cirrhosis. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, SA Australia, 10–12 October 2016. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/jgh.13520

Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes

Patel, P. J., Stuart, K. A., Horsfall, L. U., Hossain, F., Williams, S., Johnson, T., Brown, N., Lampe, G., Buck, L., Clouston, A., Irvine, K. M., Russell, A. and Powell, E. E. (2016). Non-invasive markers indicate a high prevalence of advanced fibrosis in adults with type 2 diabetes. Gastroenterological Society of Australia, Australian Gastroenterology Week 2016, Adelaide, South Australia, Australia, 10–12 October, 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13520

Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation

Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087

Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury

Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.

Discrepancies in the use of medications in patients with cirrhosis

Hayward, K., Valery, P. C., Cottrell, N., Irvine, K., Horsfall, L., Ruffin, B., Tallis, C., Chachay, V., Martin, J. and Powell, E. (2015). Discrepancies in the use of medications in patients with cirrhosis. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD Australia, 28 September - 2 October 2015. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/jgh.13093

Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal

Mcphail, S. M., Horsfall, L., Irvine, K., Fagan, K. J. and Powell, E. E. (2015). Economic consideration for reducing hospital presentations among patients with decompensated cirrhosis: not all presentations avoided can be considered equal. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease

El-Atem, N., Wojcik, K., Horsfall, L., Irvine, K., Johnson, T., Mcphail, S. M. and Powell, E. E. (2015). Patterns of service utilisation within hepatology clinics: high prevalence of advanced liver disease. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

Irvine, Katharine, Wockner, Leesa F., Shanker, Mihir, Fagan, Kevin, Horsfall, Leigh, Fletcher, Linda, Ungerer, Jacobus, Pretorius, Carel J., Miller, Gregory, Clouston, Andrew D., Lampe, Guy and Powell, Elizabeth E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, United States, 13-17 November 2015. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/hep.28218

Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores

Irvine, K. M., Wockner, L. F., Shanker, M., Fagan, K. J., Horsfall, L. U., Fletcher, L. M., Ungerer, J., Pretorius, C. J., Miller, G. C., Clouston, A. D., Lampe, G. and Powell, E. E. (2015). Predicting clinical outcomes in chronic liver disease: the ELF test is superior to histology and simple scores. Gastro 2015 GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, Queensland, Australia, 28 September-2 October 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.13093

An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease

Fagan, K., Horsfall, L., Irvine, K., Fletcher, L., Tate, J., Choi, K., Nusrat, S., Melino, M., Clouston, A., Ballard, E., O'Rourke, P., Lampe, G., Ungerer, J. and Powell, E. (2014). An ELF score of >= 9.8 can identify advanced fibrosis in Australian patients with chronic liver disease. Australian Gastroenterology Week 2014, UnknownGold Coast Convention & Exhibition Centre, Broadbeach, Queensland, 22-24 October. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites

Fagan, K. J., Melino, M., Powell, E. E. and Irvine, K. M. (2014). Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_5

Spaciotemporal characterization of the cellular and molecular contributors to chronic hepatic fibrosis in a hepatotoxin-induced mouse model

Melino, M., Gadd, V., Martinez, M., Lineburg, K., Irvine, K., Clouston, A. D., Powell, E. E. and Macdonald, K. P. (2014). Spaciotemporal characterization of the cellular and molecular contributors to chronic hepatic fibrosis in a hepatotoxin-induced mouse model. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736

The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease

Gadd, Victoria L., Skoien, Richard, Fagan, Kevin, Irvine, Katharine, Powell, Elizabeth E. and Clouston, Andrew D. (2013). The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases, Washington Dc, Nov 01-05, 2013. HOBOKEN: WILEY-BLACKWELL.

Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention

Fagan, K., Irvine, K., Kumar, S., Bates, A., Horsfall, L., Feeney, G. and Powell, E. (2013). Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5

BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin

Fagan, K., Irvine, K., McWhinney, B., Fletcher, L., Horsfall, L., Johnson, L., Clouston, A., Jonsson, J., O'Rourke, P., Martin, J., Pretorius, C., Ungerer, J. and Powell, E. (2013). BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin. International Liver Congress / 48th Annual Meeting of the European Association for the Study of the Liver (EASL), Amsterdam, Netherlands, 24-28 April 2013. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(13)60527-9

Factors associated with mortality and unplanned hospital readmissions in patients with ascites

Zhao, E., Horsfall, L., Ruffin, B. J., Fagan, K. J., Irvine, K. M. and Powell, E. E. (2013). Factors associated with mortality and unplanned hospital readmissions in patients with ascites. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5

The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease

Gadd, V., Skoien, R., Fagan, K., Irvine, K., Powell, E. and Clouston, A. (2013). The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease. Australian Gastroenterology Week 2013, Melbourne Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365

Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse

Sweet, M. J., Schroder, K., Irvine, K. M., Taylor, M., Bokil, N. J., Broomfield, S., Schembri, M. A., Stacey, K. J. and Hume, D. A. (2012). Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse. European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Oxford, United Kingdom: Wiley-Blackwell. doi: 10.1111/imm.12002

The identification of novel CSF-1 target genes in human macrophages

Irvine, Katharine M., Andrews, Melanie R., Fernandez, Manuel A., Parton, Robert G., Burns, Christopher J., Su, Stephen, Wilks, Andrew F., Hume, David A. and Sweet, M. J. (2008). The identification of novel CSF-1 target genes in human macrophages. 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Montreal Canada, Oct 12-16, 2008. LONDON: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD. doi: 10.1016/j.cyto.2008.07.078

A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations

Irvine, Katharine M., Burns, Christopher J., Wilks, Andrew F., Bu, Xiangyong, Harte, Michael F., Su, Stephen, Hume, David A. and Sweet, Matthew J. (2005). A potent CSF-1 Receptor tyrosine kinase inhibitor targets survival and effector functions in marine macrophage populations. BASEL: BIRKHAUSER VERLAG AG.

PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages

Schroder, Kate, Irvine, Katharine M., Biron, Kristian, Lichtinger, Monika, Ravasi, Timothy, Rehli, Michael, Sweet, Matthen J. and Hume, David A. (2005). PU.1 and ICSBP regulate the tlr9 promoter in mouse macrophages. BASEL: BIRKHAUSER VERLAG AG.

Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.

Katharine Irvine (2024). Supplementary Material for the article published in American Journal of PhysiologyEndocrinology and Metabolism December 2023.. The University of Queensland. (Dataset) doi: 10.48610/ef2c29e

CSF1R_FRed_SupplementaryVideos

Irvine, Katharine, Hume, David and Sehgal, Anuj (2020). CSF1R_FRed_SupplementaryVideos. The University of Queensland. (Dataset) doi: 10.14264/8c6d4ba

The expression and function of G3BPs in macrophages

Irvine, Katharine Margaret. (2004). The expression and function of G3BPs in macrophages. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/272818