The University of Queensland

CW and pulse EPR of cytochrome P450 to determine structure and function

Harbort, Joshua S., De Voss, James J., Stok, Jeanette E., Bell, Stephen G. and Harmer, Jeffrey R. (2017). CW and pulse EPR of cytochrome P450 to determine structure and function. Future directions in metalloprotein and metalloenzyme research. (pp. 103-142) edited by Graeme Hanson and Lawrence Berliner. New York, United States: Springer. doi: 10.1007/978-3-319-59100-1_5

Cytochrome P450cin (CYP176A1)

Stok, Jeanette E., Slessor, Kate E., Farlow, Anthony J., Hawkes, David B. and De Voss, James J. (2015). Cytochrome P450cin (CYP176A1). Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450. (pp. 319-339) edited by Eugene G. Hrycay and Stelvio M. Bandiera. New York, NY United States: Springer New York LLC. doi: 10.1007/978-3-319-16009-2_12

Plant steroidal saponins: A focus on open-chain glycosides

Challinor, Victoria L. and de Voss, James J. (2013). Plant steroidal saponins: A focus on open-chain glycosides. Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. (pp. 3225-3250) edited by Kishan Gopal Ramawat and Jean-Michel Mérillon. Berlin, Germany: Springer. doi: 10.1007/978-3-642-22144-6_139

Carbon-Carbon Bond Cleavage by P450 Systems

De Voss, J. and Cryle, M. (2007). Carbon-Carbon Bond Cleavage by P450 Systems. The Ubiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences, Volume 3. (pp. 397-435) edited by A. Sigel, H. Sigel and R. Sigel. United Kingdom: Wiley & Sons. doi: 10.1002/9780470028155.ch13

Substrate oxidation by cytochrome P450 enzymes

Ortiz de Montellano, P.R. and De Voss, J. J. (2005). Substrate oxidation by cytochrome P450 enzymes. Cytochrome P450: Structure, Mechanism and Biochemistry. (pp. 183-245) edited by P. Ortiz de Montellano. New York: Kluwer/Plenum. doi: 10.1007/0-387-27447-2_6

Synthesis of steroidal inhibitors for Mycobacterium tuberculosis

Churchman, Luke R., Beckett, James R., Tan, Lendl, Woods, Kyra, Doherty, Daniel Z., Ghith, Amna, Bernhardt, Paul V., Bell, Stephen G., West, Nicholas P. and De Voss, James J. (2024). Synthesis of steroidal inhibitors for Mycobacterium tuberculosis. The Journal of Steroid Biochemistry and Molecular Biology, 239 106479, 1-16. doi: 10.1016/j.jsbmb.2024.106479

An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides

Treisman, Maxine, Coe, Laura, Zhao, Yongwei, Sasi, Vishnu Mini, Gullick, Jemma, Hansen, Mathias H., Ly, Aviva, Leichthammer, Victor, Hess, Caroline, Machell, Daniel L., Schittenhelm, Ralf B., Hooper, Joel, Jackson, Colin J., Tailhades, Julien, De Voss, James J. and Cryle, Max J. (2024). An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides. Organic Letters, 26 (9), 1828-1833. doi: 10.1021/acs.orglett.3c04366

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

Hansen, Mathias H., Keto, Angus, Treisman, Maxine, Sasi, Vishnu Mini, Coe, Laura, Zhao, Yongwei, Padva, Leo, Hess, Caroline, Leichthammer, Victor, Machell, Daniel L., Schittenhelm, Ralf B., Jackson, Colin J., Tailhades, Julien, Crüsemann, Max, De Voss, James J., Krenske, Elizabeth H. and Cryle, Max J. (2024). Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis. ACS Catalysis, 14 (2), 812-826. doi: 10.1021/acscatal.3c05417

CYP108N14: A Monoterpene Monooxygenase from Rhodococcus globerulus

Giang, Peter D., Churchman, Luke R., Buczynski, Julia B., Bell, Stephen G., Stok, Jeanette E. and De Voss, James J. (2023). CYP108N14: A Monoterpene Monooxygenase from Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 752 109852, 109852. doi: 10.1016/j.abb.2023.109852

Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizome

Carpinelli de Jesus, Matheus, Church, Taylah, Wapling, Johanna A., Collins, Raelene, Leach, Gregory J., Leach, David, De Voss, James J. and Blanchfield, Joanne T. (2023). Differentiating dyes: A Spectroscopic investigation into the composition of scarlet bloodroot (Haemodorum coccineum R.Br.) rhizome. Molecules, 28 (21) 7422, 1-14. doi: 10.3390/molecules28217422

Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450

Gee, Alecia R., Stone, Isobella S. J., Stockdale, Tegan P., Pukala, Tara L., De Voss, James J. and Bell, Stephen G. (2023). Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450. Chemical Communications, 59 (90), 13486-13489. doi: 10.1039/d3cc04626e

The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymes

Podgorski, Matthew N, Keto, Angus B, Coleman, Tom, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2023). The oxidation of oxygen and sulfur‐containing heterocycles by cytochrome P450 enzymes. Chemistry – A European Journal, 29 (50) e202301371, e202301371. doi: 10.1002/chem.202301371

Cytochrome P450-catalyzed oxidation of halogen-containing substrates

Coleman, Tom, Podgorski, Matthew N., Doyle, Maya L., Scaffidi-Muta, Jarred M., Campbell, Eleanor C., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2023). Cytochrome P450-catalyzed oxidation of halogen-containing substrates. Journal of Inorganic Biochemistry, 244 112234, 1-12. doi: 10.1016/j.jinorgbio.2023.112234

Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase

Akter, Jinia, Stockdale, Tegan P., Child, Stella A., Lee, Joel H. Z., De Voss, James J. and Bell, Stephen G. (2023). Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase. Journal of Inorganic Biochemistry, 244 112209, 1-9. doi: 10.1016/j.jinorgbio.2023.112209

The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterol

Doherty, Daniel Z., Ghith, Amna, Ho, Ava, De Voss, James J. and Bell, Stephen G. (2023). The bacterial cytochrome P450 (CYP) CYP125 enzymes can competitively oxidise sitosterol in the presence of cholesterol. Chemical Communications, 59 (61), 9392-9395. doi: 10.1039/d3cc02312e

Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa

Salisbury, Lauren J., Fletcher, Stephen J., Stok, Jeanette E., Churchman, Luke R., Blanchfield, Joanne T. and De Voss, James J. (2023). Characterization of the cholesterol biosynthetic pathway in Dioscorea transversa. Journal of Biological Chemistry, 299 (6) 104768, 1-16. doi: 10.1016/j.jbc.2023.104768

Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme

Miller, Justin C., Lee, Joel H. Z., Mclean, Mark A., Chao, Rebecca R., Stone, Isobella S. J., Pukala, Tara L., Bruning, John B., De Voss, James J., Schuler, Mary A., Sligar, Stephen G. and Bell, Stephen G. (2023). Engineering C–C bond cleavage activity into a P450 monooxygenase enzyme. Journal of the American Chemical Society, 145 (16), 9207-9222. doi: 10.1021/jacs.3c01456

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w

Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12

Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Cymredoxin, a [2Fe–2S] ferredoxin, supports catalytic activity of the p-cymene oxidising P450 enzyme CYP108N12. Archives of Biochemistry and Biophysics, 737 109549, 109549. doi: 10.1016/j.abb.2023.109549

Synthesis of substituted norcaranes for use as probes of enzyme mechanisms

Churchman, Luke R., Giang, Peter D., Buczynski, Julia B., Stok, Jeanette E., Bell, Stephen G. and De Voss, James J. (2023). Synthesis of substituted norcaranes for use as probes of enzyme mechanisms. Organic & Biomolecular Chemistry, 21 (48), 9647-9658. doi: 10.1039/d3ob01571h

Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions

Podgorski, Matthew N., Coleman, Tom, Churchman, Luke R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2022). Investigating the active oxidants involved in cytochrome P450 catalyzed sulfoxidation reactions. Chemistry: A European Journal, 28 (72) e202202428, 1-12. doi: 10.1002/chem.202202428

Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylation

Coleman, Tom, Doherty, Daniel Z., Zhang, Ting, Podgorski, Matthew N., Qiao, Ruihong, Lee, Joel H. Z., Bruning, John B., De Voss, James J., Zhou, Weihong and Bell, Stephen G. (2022). Exploring the factors which result in cytochrome P450 catalyzed desaturation versus hydroxylation. Chemistry - An Asian Journal, 17 (24) e202200986, 1-14. doi: 10.1002/asia.202200986

Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineering

Coleman, Tom, Lee, Joel, Kirk, Alicia M, Doherty, Daniel Z, Podgorski, Matthew N, Pinidiya, Dilshi K, Bruning, John B, De Voss, James J, Krenske, Elizabeth H and Bell, Stephen Graham (2022). Enabling aromatic hydroxylation in a cytochrome P450 monooxygenase rnzyme through protein engineering. Chemistry: A European Journal, 28 (67) e202201895, 1-14. doi: 10.1002/chem.202201895

CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulus

Giang, Peter D., Churchman, Luke R., Stok, Jeanette E., Soo, Rochelle M. and De Voss, James J. (2022). CYP108N12 initiates p-cymene biodegradation in Rhodococcus globerulus. Archives of Biochemistry and Biophysics, 730 109410, 109410. doi: 10.1016/j.abb.2022.109410

Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves

Jesus, Matheus Carpinelli De, Wapling, Johanna, Kiem, Eunice, Stockdale, Tegan, Whittaker, Jacob J., Clegg, Jack K., Leach, David, Church, Taylah, Collins, Raelene, Leach, Greg, Hewitt, David, De Voss, James J. and Blanchfield, Joanne T. (2022). Phytochemical composition of Denhamia obscura (A. Rich.) Meisn. Ex Walp. root bark, seeds and leaves. Arkivoc, 2022 (4), 123-142. doi: 10.24820/ark.5550190.p011.828

Synthesis of obtusifoliol and analogues as CYP51 substrates

Churchman, Luke R., Salisbury, Lauren J. and De Voss, James J. (2022). Synthesis of obtusifoliol and analogues as CYP51 substrates. Organic and Biomolecular Chemistry, 20 (36), 7316-7324. doi: 10.1039/d2ob01307j

The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinum

Ghith, Amna, Doherty, Daniel Z., Bruning, John B., Russell, Robert A., De Voss, James J. and Bell, Stephen G. (2022). The structures of the steroid binding CYP142 cytochrome P450 enzymes from Mycobacterium ulcerans and Mycobacterium marinum. ACS Infectious Diseases, 8 (8), 1606-1617. doi: 10.1021/acsinfecdis.2c00215

The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage

Greule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R. and Cryle, Max J. (2022). The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage. Frontiers in Chemistry, 10 868240, 868240. doi: 10.3389/fchem.2022.868240

Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation

Coleman, Tom, Kirk, Alicia M., Lee, Joel H. Z., Doherty, Daniel Z., Bruning, John B., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2022). Different geometric requirements for cytochrome P450-catalyzed aliphatic versus aromatic hydroxylation results in chemoselective oxidation. ACS Catalysis, 12 (2), 1258-1267. doi: 10.1021/acscatal.1c05483

To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzyme

Podgorski, Matthew N., Coleman, Tom, Giang, Peter D., Wang, C. Ruth, Bruning, John B., Bernhardt, Paul V., De Voss, James J. and Bell, Stephen G. (2022). To be, or not to be, an inhibitor: a comparison of Azole interactions with and oxidation by a cytochrome P450 enzyme. Inorganic Chemistry, 61 (1) acs.inorgchem.1c02786, 236-245. doi: 10.1021/acs.inorgchem.1c02786

The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst

Chao, Rebecca R., Lau, Ian C.-K., Coleman, Tom, Churchman, Luke R., Child, Stella A., Lee, Joel H. Z., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2021). The stereoselective oxidation of para-substituted benzenes by a cytochrome P450 biocatalyst. Chemistry - A European Journal, 27 (59), 14765-14777. doi: 10.1002/chem.202102757

The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruits

Huang, Li, Yong, Ken W. L., Fernando, W. Chrishanthi, Carpinelli de Jesus, Matheus, De Voss, James J., Sultanbawa, Yasmina and Fletcher, Mary T. (2021). The inactivation by curcumin-mediated photosensitization of Botrytis cinerea apores isolated from strawberry fruits. Toxins, 13 (3) 196, 196. doi: 10.3390/toxins13030196

Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme

Coleman, Tom, Kirk, Alicia M., Chao, Rebecca R., Podgorski, Matthew N., Harbort, Joshua S., Churchman, Luke R., Bruning, John B., Bernhardt, Paul V., Harmer, Jeffrey R., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2021). Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme. ACS Catalysis, 11 (4), 1995-2010. doi: 10.1021/acscatal.0c04872

Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herb

Ahmed, Iftekhar, Leach, David N., Wohlmuth, Hans, De Voss, James J. and Blanchfield, Joanne T. (2020). Caco-2 cell permeability of flavonoids and saponins from Gynostemma pentaphyllum: the immortal herb. ACS Omega, 5 (34) acsomega.0c02180, 21561-21569. doi: 10.1021/acsomega.0c02180

A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues

Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie, 132 (27), 10991-10995. doi: 10.1002/ange.202003726

Oxygen surrogate systems for supporting human drug-metabolizing cytochrome P450 enzymes

Strohmaier, Silja J., De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). Oxygen surrogate systems for supporting human drug-metabolizing cytochrome P450 enzymes. Drug Metabolism and Disposition , 48 (6), 432-437. doi: 10.1124/dmd.120.090555

A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues

Tailhades, Julien, Zhao, Yongwei, Ho, Y. T. Candace, Greule, Anja, Ahmed, Iftekhar, Schoppet, Melanie, Kulkarni, Ketav, Goode, Rob J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2020). A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues. Angewandte Chemie International Edition, 59 (27) anie.202003726, 10899-10903. doi: 10.1002/anie.202003726

Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes

Coleman, Tom, Stok, Jeanette E., Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2020). Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes. JBIC Journal of Biological Inorganic Chemistry, 25 (4), 583-596. doi: 10.1007/s00775-020-01781-4

Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases

Podgorski, Matthew N., Harbort, Joshua S., Coleman, Tom, Stok, Jeanette E., Yorke, Jake A., Wong, Luet-Lok, Bruning, John B., Bernhardt, Paul V., De Voss, James J., Harmer, Jeffrey R. and Bell, Stephen G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59 (9) acs.biochem.0c00027, 1038-1050. doi: 10.1021/acs.biochem.0c00027

An inexpensive, efficient alternative to NADPH to support catalysis by thermostable cytochrome P450 enzymes

Strohmaier, Silja J., Baek, Jong Min, De Voss, James J., Jurva, Ulrik, Andersson, Shalini and Gillam, Elizabeth M. J. (2020). An inexpensive, efficient alternative to NADPH to support catalysis by thermostable cytochrome P450 enzymes. ChemCatChem, 12 (6) cctc.201902235, 1750-1761. doi: 10.1002/cctc.201902235

Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions

Podgorski, Matthew N., Coleman, Tom, Chao, Rebecca R., De Voss, James J., Bruning, John B. and Bell, Stephen G. (2020). Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions. Journal of Inorganic Biochemistry, 203 110913, 1-13. doi: 10.1016/j.jinorgbio.2019.110913

Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound

Sarkar, Md. Raihan, Houston, Sevan D., Savage, G. Paul, Williams, Craig M., Krenske, Elizabeth H., Bell, Stephen G. and De Voss, James J. (2019). Rearrangement-free hydroxylation of methylcubanes by a cytochrome P450: the case for dynamical coupling of C–H abstraction and rebound. Journal of the American Chemical Society, 141 (50) jacs.9b08064, 19688-19699. doi: 10.1021/jacs.9b08064

Exploring the substrate specificity of cytochrome P450cin

Stok, Jeanette E., Giang, Peter D., Wong, Siew Hoon and De Voss, James J. (2019). Exploring the substrate specificity of cytochrome P450cin. Archives of Biochemistry and Biophysics, 672 108060, 108060. doi: 10.1016/j.abb.2019.07.025

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Houston, Sevan D., Fahrenhorst-Jones, Tyler, Xing, Hui, Chalmers, Benjamin A., Sykes, Melissa L., Stok, Jeanette E., Farfan Soto, Clementina, Burns, Jed M., Bernhardt, Paul V., De Voss, James J., Boyle, Glen M., Smith, Maree T., Tsanaktsidis, John, Savage, G. Paul, Avery, Vicky M. and Williams, Craig M. (2019). The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement. Organic and Biomolecular Chemistry, 17 (28), 6790-6798. doi: 10.1039/c9ob01238a

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Greule, Anja, Izoré, Thierry, Iftime, Dumitrita, Tailhades, Julien, Schoppet, Melanie, Zhao, Yongwei, Peschke, Madeleine, Ahmed, Iftekhar, Kulik, Andreas, Adamek, Martina, Goode, Robert J. A., Schittenhelm, Ralf B., Kaczmarski, Joe A., Jackson, Colin J., Ziemert, Nadine, Krenske, Elizabeth H., De Voss, James J., Stegmann, Evi and Cryle, Max J. (2019). Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nature Communications, 10 (1) 2613, 2613. doi: 10.1038/s41467-019-10384-w

Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey

Carpinelli de Jesus, Matheus, Hungerford, Natasha L., Carter, Steve J., Anuj, Shalona R., Blanchfield, Joanne T., De Voss, James Joseph and Fletcher, Mary T. (2019). Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey. Journal of Agricultural and Food Chemistry, 67 (28) acs.jafc.9b02136, 7995-8006. doi: 10.1021/acs.jafc.9b02136

Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins

Stockdale, Tegan P., Challinor, Victoria L., Lehmann, Reginald P., De Voss, James J. and Blanchfield, Joanne T. (2019). Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins. ACS Omega, 4 (4), 7658-7666. doi: 10.1021/acsomega.9b00496

Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants

Lee, Joel H.Z., Wong, Siew Hoon, Stok, Jeanette E., Bagster, Sarah A., Beckett, James, Clegg, Jack K., Brock, Aidan, De Voss, James J. and Bell, Stephen G. (2019). Selective hydroxylation of 1,8- and 1,4-cineole using bacterial P450 variants. Archives of Biochemistry and Biophysics, 663, 54-63. doi: 10.1016/j.abb.2018.12.025

Significance of protein-substrate hydrogen bonding for the selectivity of P450-catalysed oxidations

Slessor, Kate E., Stok, Jeanette E., Chow, Sharon and De Voss, James J. (2019). Significance of protein-substrate hydrogen bonding for the selectivity of P450-catalysed oxidations. Chemistry: A European Journal, 25 (16), 4149-4155. doi: 10.1002/chem.201805705

Cyclooctatetraene: a bioactive cubane paradigm complement

Xing, Hui, Houston, Sevan D., Chen, Xuejie, Ghassabian, Sussan, Fahrenhorst-Jones, Tyler, Kuo, Andy, Murray, Cody-Ellen P., Conn, Kyna-Anne, Jaeschke, Kara N., Jin, Da-Yun, Pasay, Cielo, Bernhardt, Paul V., Burns, Jed M., Tsanaktsidis, John, Savage, G. Paul, Boyle, Glen M., De Voss, James J., McCarthy, James, Walter, Gimme H., Burne, Thomas H. J., Smith, Maree T., Tie, Jian-Ke and Williams, Craig M. (2019). Cyclooctatetraene: a bioactive cubane paradigm complement. Chemistry: A European Journal, 25 (11), 2729-2734. doi: 10.1002/chem.201806277

Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE)

Gumulya, Yosephine, Huang, Weiliang, D'Cunha, Stephlina A., Richards, Katelyn E., Thomson, Raine E.S., Hunter, Dominic J.B., Baek, Jong-Min, Harris, Kurt L., Boden, Mikael, De Voss, James J., Hayes, Martin A., Isin, Emre M., Andersson, Shalini, Jurva, Ulrik and Gillam, Elizabeth (2019). Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE). ChemCatChem, 11 (2) cctc.201801644, 841-850. doi: 10.1002/cctc.201801644

Enzymatic cascade to evaluate the tricyclization of glycopeptide antibiotic precursor peptides as a prequel to biosynthetic redesign

Tailhades, Julien, Zhao, Yongwei, Schoppet, Melanie, Greule, Anja, Goode, Robert J. A., Schittenhelm, Ralf B., De Voss, James J. and Cryle, Max J. (2019). Enzymatic cascade to evaluate the tricyclization of glycopeptide antibiotic precursor peptides as a prequel to biosynthetic redesign. Organic Letters, 21 (21) acs.orglett.9b03245, 8635-8640. doi: 10.1021/acs.orglett.9b03245

Engineering highly functional thermostable proteins using ancestral sequence reconstruction

Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018). Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 (11), 878-888. doi: 10.1038/s41929-018-0159-5

Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161

Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyzes heteroatom dealkylations, sulfoxidation, and amide and cyclic hemiacetal formation

Coleman, Tom, Wong, Siew Hoon, Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2018). Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyzes heteroatom dealkylations, sulfoxidation, and amide and cyclic hemiacetal formation. ACS Catalysis, 8 (7), 5915-5927. doi: 10.1021/acscatal.8b00909

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

Greule, Anja, Stok, Jeanette E., De Voss, James J. and Cryle, Max J. (2018). Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Natural Product Reports, 35 (8), 757-791. doi: 10.1039/c7np00063d

Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice

Daygon, Venea Dara, Calingacion, Mariafe, Forster, Louise C., De Voss, James J., Schwartz, Brett D., Ovenden, Ben, Alonso, David E., McCouch, Susan R., Garson, Mary J. and Fitzgerald, Melissa A. (2017). Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice. Scientific Reports, 7 (1) 8767, 8767. doi: 10.1038/s41598-017-07693-9

Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars

San, Anh T., Joyce, Daryl C., Hofman, Peter J., Macnish, Andrew J., Webb, Richard I., Matovic, Nicolas J., Williams, Craig M., De Voss, James J., Wong, Siew H. and Smyth, Heather E. (2017). Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chemistry, 221, 613-619. doi: 10.1016/j.foodchem.2016.11.130

Modification of an enzyme biocatalyst for the efficient and selective oxidative demethylation of para-substituted benzene derivatives

Chao, Rebecca R., Lau, Ian C. -K., De Voss, James J. and Bell, Stephen G. (2016). Modification of an enzyme biocatalyst for the efficient and selective oxidative demethylation of para-substituted benzene derivatives. ChemCatChem, 8 (23), 3626-3635. doi: 10.1002/cctc.201600951

Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat

Tan, Eddie T. T., Yong, Ken W. L., Wong, Siew-Hoon, D'Arcy, Bruce R., Al Jassim, Rafat, De Voss, James J. and Fletcher, Mary T. (2016). Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat. Journal of Agricultural And Food Chemistry, 64 (44), 8447-8453. doi: 10.1021/acs.jafc.6b03499

The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4

Chao, Rebecca R., De Voss, James J. and Bell, Stephen G. (2016). The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4. Rsc Advances, 6 (60), 55286-55297. doi: 10.1039/c6ra11025h

In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1

Stok, Jeanette E., Hall, Emma A., Stone, Isobella S. J, Noble, Margaret C., Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2016). In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1. Journal of Molecular Catalysis B: Enzymatic, 128, 52-64. doi: 10.1016/j.molcatb.2016.03.004

The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2

Coleman, Tom, Chao, Rebecca R., de Voss, James J. and Bell, Stephen G. (2016). The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2. Biochimica et Biophysica Acta, 1864 (6), 667-675. doi: 10.1016/j.bbapap.2016.03.006

Cholesterol analogs with degradation-resistant alkyl side chains are effective Mycobacterium tuberculosis growth inhibitors

Frank, Daniel J., Zhao, Yan, Wong, Siew Hoon, Basudhar, Debashree, De Voss, James J. and De Montellano, Paul R. Ortiz (2016). Cholesterol analogs with degradation-resistant alkyl side chains are effective Mycobacterium tuberculosis growth inhibitors. Journal of Biological Chemistry, 291 (14), 7325-7333. doi: 10.1074/jbc.M115.708172

Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161

Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation

Stok, Jeanette E., Chow, Sharon, Krenske, Elizabeth H., Farfan Soto, Clementina, Matyas, Csongor, Poirier, Raymond A., Williams, Craig M. and De Voss, James J. (2016). Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation. Chemistry: A European Journal, 22 (13), 4408-4412. doi: 10.1002/chem.201600246

Validating Eaton's hypothesis: cubane as a benzene bioisostere

Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675

Synthesis of L-Indospicine, [5,5,6-2H3 ]- L-Indospicine and L-Norindospicine

Lang, Cheng-Shan, Wong, Siew-Hoon, Chow, Sharon, Challinor, Victoria L., Yong, Ken W. L., Fletcher, Mary T., Arthur, Dionne M., Ng, Jack C. and De Voss, James J. (2016). Synthesis of L-Indospicine, [5,5,6-2H3 ]- L-Indospicine and L-Norindospicine. Organic and Biomolecular Chemistry, 14 (28), 6826-6832. doi: 10.1039/C6OB01187J

Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa

Challinor, Victoria L., Johnston, Ryne C., Bernhardt, Paul V., Lehmann, Reginald P., Krenske, Elizabeth H. and De Voss, James J. (2015). Biosynthetic insights provided by unusual sesterterpenes from the medicinal herb Aletris farinosa. Chemical Science, 6 (10), 5740-5745. doi: 10.1039/c5sc02056e

CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives

Coleman, Tom, Chao, Rebecca R., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2015). CYP199A4 catalyses the efficient demethylation and demethenylation of para-substituted benzoic acid derivatives. RSC Advances, 5 (64), 52007-52018. doi: 10.1039/c5ra08730a

Electrochemically mediated enantioselective reduction of chiral sulfoxides

Chen, Kuan I., Challinor, Victoria L., Kielmann, Linda, Sharpe, Philip C., De Voss, James J., Kappler, Ulrike, McEwan, Alastair G. and Bernhardt, Paul V. (2014). Electrochemically mediated enantioselective reduction of chiral sulfoxides. Journal of Biological Inorganic Chemistry, 20 (2), 395-402. doi: 10.1007/s00775-014-1215-5

Oxidative carbon-carbon bond cleavage is a key step in spiroacetal biosynthesis in the fruit fly Bactrocera cacuminata

Singh, Arti A., Rowley, Jessica A., Schwartz, Brett D., Kitching, William and De Voss, James J. (2014). Oxidative carbon-carbon bond cleavage is a key step in spiroacetal biosynthesis in the fruit fly Bactrocera cacuminata. Journal of Organic Chemistry, 79 (17), 7799-7821. doi: 10.1021/jo500791y

Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB

Alonso, Hernan, Kleifeld, Oded, Yeheskel, Adva, Ong, Poh C., Liu, Yu C., Stok, Jeanette E., De Voss, James J. and Roujeinikova, Anna (2014). Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB. Biochemical Journal, 460 (2), 283-293. doi: 10.1042/BJ20131648

Carbon-Carbon bond cleavage in activation of the prodrug nabumetone

Varfaj, Fatbardha, Zulkifli, Siti N. A., Park, Hyoung-Goo, Challinor, Victoria L., De Voss, James J. and De Montellano, Paul R. Ortiz (2014). Carbon-Carbon bond cleavage in activation of the prodrug nabumetone. Drug Metabolism and Disposition, 42 (5), 828-838. doi: 10.1124/dmd.114.056903

Synthesis and determination of the absolute configuration of (-)-(5R,6Z)-dendrolasin-5-acetate from the nudibranch Hypselodoris jacksoni

Mudianta, I. Wayan, Challinor, Victoria L., Winters, Anne E., Cheney, Karen L., De Voss, James J. and Garson, Mary J. (2013). Synthesis and determination of the absolute configuration of (-)-(5R,6Z)-dendrolasin-5-acetate from the nudibranch Hypselodoris jacksoni. Beilstein Journal of Organic Chemistry, 9 (1), 2925-2933. doi: 10.3762/bjoc.9.329

Structure and absolute configuration of methyl (3R)-malonyl-(13S)-hydroxycheilanth-17-en-19-oate, a sesterterpene derivative from the roots of Aletris farinosa

Challinor, Victoria L., Chap, Sonet, Lehmann, Reginald P., Bernhardt, Paul V. and De Voss, James J. (2013). Structure and absolute configuration of methyl (3R)-malonyl-(13S)-hydroxycheilanth-17-en-19-oate, a sesterterpene derivative from the roots of Aletris farinosa. Journal of Natural Products, 76 (4), 485-488. doi: 10.1021/np400035n

Synthesis of oxygenated cineole derivatives from cineole: utility of cytochrome P450(cin) as an enantioselective catalyst

Farlow, Anthony J., Bernhardt, Paul V. and De Voss, James J. (2013). Synthesis of oxygenated cineole derivatives from cineole: utility of cytochrome P450(cin) as an enantioselective catalyst. Tetrahedron: Asymmetry, 24 (5-6), 324-333. doi: 10.1016/j.tetasy.2013.02.004

Cytochrome P450(cin) (CYP176A1) D241N: investigating the role of the conserved acid in the active site of cytochrome P450s

Stok, Jeanette E., Yamada, Sean, Farlow, Anthony J., Slessor, Kate E. and De Voss, James J. (2013). Cytochrome P450(cin) (CYP176A1) D241N: investigating the role of the conserved acid in the active site of cytochrome P450s. Biochimica et Biophysica Acta: Proteins and Proteomics, 1834 (3), 688-696. doi: 10.1016/j.bbapap.2012.12.022

Open-chain steroidal glycosides, a diverse class of plant saponins

Challinor, Victoria L. and De Voss, James J. (2013). Open-chain steroidal glycosides, a diverse class of plant saponins. Natural Product Reports, 30 (3), 429-454. doi: 10.1039/c3np20105h

Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3) -catalysed oxidation of cyclopropyl fatty acids

Cryle, Max J., Hayes, Patricia Y. and De Voss, James J. (2012). Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3) -catalysed oxidation of cyclopropyl fatty acids. Chemistry : A European Journal, 18 (50), 15994-15999. doi: 10.1002/chem.201203035

Plakortolide stereochemistry revisited: the checkered history of plakortolides e and i

Yong, Ken W. L., Barnych, Bogdan, De Voss, James J., Vatele, Jean-Michael and Garson, Mary J. (2012). Plakortolide stereochemistry revisited: the checkered history of plakortolides e and i. Journal of Natural Products, 75 (10), 1792-1797. doi: 10.1021/np3005634

Structure and bioactivity of steroidal saponins isolated from the roots of Chamaelirium luteum (False Unicorn)

Challinor, Victoria L., Stuthe, Julia M. U., Parsons, Peter G., Lambert, Lynette K., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2012). Structure and bioactivity of steroidal saponins isolated from the roots of Chamaelirium luteum (False Unicorn). Journal of Natural Products, 75 (8), 1469-1479. doi: 10.1021/np300393y

An in vivo cytochrome P450(cin) (CYP176A1) catalytic system for metabolite production

Slessor, Kate E., Hawkes, David B., Farlow, Anthony, Pearson, Andrew G., Stok, Jeanette E. and De Voss, James J. (2012). An in vivo cytochrome P450(cin) (CYP176A1) catalytic system for metabolite production. Journal of Molecular Catalysis B: Enzymatic, 79, 15-20. doi: 10.1016/j.molcatb.2012.03.007

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1

Johnston, Jonathan B., Singh, Arti A., Clary, Anaelle A., Chen, Chiung-Kuan, Hayes, Patricia Y., Chow, Sharon, De Voss, James J. and de Montellano, Paul R. O. (2012). Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorganic and Medicinal Chemistry, 20 (13), 4064-4081. doi: 10.1016/j.bmc.2012.05.003

NMR assignment of the absolute configuration of C-25 in furostanol steroidal saponins

Challinor, Victoria L., Piacente, Sonia and De Voss, James J. (2012). NMR assignment of the absolute configuration of C-25 in furostanol steroidal saponins. Steroids, 77 (6), 602-608. doi: 10.1016/j.steroids.2012.02.002

Steroidal saponins from the roots of Smilax sp.: Structure and bioactivity

Challinor, Victoria L., Parsons, Peter G., Chap, Sonet, White, Eve F., Blanchfield, Joanne T., Lehmann, Reginald P. and De Voss, James J. (2012). Steroidal saponins from the roots of Smilax sp.: Structure and bioactivity. Steroids, 77 (5), 504-511. doi: 10.1016/j.steroids.2012.01.009

Oxidative processes in the Australian marine sponge Plakinastrella clathrata: Isolation of plakortolides with oxidatively modified side chains

Yong, Ken W. L., Lambert, Lynette K., Hayes, Patricia Y., De Voss, James J. and Garson, Mary J. (2012). Oxidative processes in the Australian marine sponge Plakinastrella clathrata: Isolation of plakortolides with oxidatively modified side chains. Journal of Natural Products, 75 (3), 351-360. doi: 10.1021/np200619q

Assignment of stereochemistry in open-chain steroidal saponins

Challinor, Victoria L. and De Voss, James J. (2012). Assignment of stereochemistry in open-chain steroidal saponins. Pure and Applied Chemistry, 84 (6), 1469-1478. doi: 10.1351/PAC-CON-11-09-12

Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli

Watts, Rebecca E., Totsika, Makrina, Challinor, Victoria L., Mabbett, Amanda N., Ulett, Glen C., De Voss, James J. and Schembri, Mark A. (2012). Contribution of siderophore systems to growth and urinary tract colonization of asymptomatic bacteriuria Escherichia coli. Infection and Immunity, 80 (1-2), 333-344. doi: 10.1128/IAI.05594-11

Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes

Johnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011). Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 (47), 40750-40759. doi: 10.1074/jbc.M111.300871

Crotalaria medicaginea associated with horse deaths in Northern Australia: New pyrrolizidine alkaloids

Fletcher, Mary T., Hayes, Patricia Y., Somerville, Michael J. and De Voss, James J. (2011). Crotalaria medicaginea associated with horse deaths in Northern Australia: New pyrrolizidine alkaloids. Journal of Agricultural and Food Chemistry, 59 (21), 11888-11892. doi: 10.1021/jf203147x

Facile production of minor metabolites for drug development using a CYP3A shuffled library

Hunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011). Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 (6), 682-693. doi: 10.1016/j.ymben.2011.09.001

Increased plant volatile production affects oviposition, but not larval development, in the moth Helicoverpa armigera

McCallum, Emily J., Cunningham, John Paul, Lücker, Joost, Zalucki, Myron P., De Voss, James J . and Botella, José R. (2011). Increased plant volatile production affects oviposition, but not larval development, in the moth Helicoverpa armigera. Journal of Experimental Biology, 214 (21), 3672-3677. doi: 10.1242/jeb.059923

Synthesis of highly enantioenriched hydroxy- and dihydroxy-fatty esters: substrate precursors for cytochrome P450(BioI)

Singh, Arti A., Zulkifli, Siti N. A., Meyns, Michaela, Hayes, Patricia Y. and De Voss, James J. (2011). Synthesis of highly enantioenriched hydroxy- and dihydroxy-fatty esters: substrate precursors for cytochrome P450(BioI). Tetrahedron-Asymmetry, 22 (18-19), 1709-1719. doi: 10.1016/j.tetasy.2011.08.027

Revision of the absolute configurations of bethosides B and C and their aglycone

Challinor, Victoria L., Hayes, Patricia Y., Bernhardt, Paul V., Kitching, William, Lehmann, Reginald P. and De Voss, James J. (2011). Revision of the absolute configurations of bethosides B and C and their aglycone. Journal of Organic Chemistry, 76 (17), 7275-7280. doi: 10.1021/jo2012797

Structure and absolute configuration of helosides A and B, new saponins from Chamaelirium luteum

Challinor, Victoria L., Stuthe, Julia M. U., Bernhardt, Paul V., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2011). Structure and absolute configuration of helosides A and B, new saponins from Chamaelirium luteum. Journal of Natural Products, 74 (7), 1557-1560. doi: 10.1021/np200100a

The truth about false unicorn (Chamaelirium luteum): Total synthesis of 23R,24S-Chiograsterol B defines the structure and stereochemistry of the major saponins from this medicinal herb

Matovic, Nicholas J., Stuthe, Julia M. U., Challinor, Victoria L., Bernhardt, Paul V., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2011). The truth about false unicorn (Chamaelirium luteum): Total synthesis of 23R,24S-Chiograsterol B defines the structure and stereochemistry of the major saponins from this medicinal herb. Chemistry-A European Journal, 17 (27), 7578-7591. doi: 10.1002/chem.201100503

Polyunsaturated alkyl amides from Echinacea: Synthesis of diynes, enynes, and dienes

Matovic, Nicholas J., Hayes, Patricia Y., Penman, Kerry, Lehmann, Reginald P. and De Voss, James J. (2011). Polyunsaturated alkyl amides from Echinacea: Synthesis of diynes, enynes, and dienes. Journal of Organic Chemistry, 76 (11), 4467-4481. doi: 10.1021/jo200289f

The First International Collaborative and Cooperative Chemistry Symposium

De Voss, James J. (2011). The First International Collaborative and Cooperative Chemistry Symposium. Australian Journal of Chemistry, 64 (5), 517-518. doi: 10.1071/CH11187

Oxygen activation by P450(cin): Protein and substrate mutagenesis

Slessor, KE, Farlow, AJ, Cavaignac, SM, Stok, JE and De Voss, JJ (2011). Oxygen activation by P450(cin): Protein and substrate mutagenesis. Archives of Biochemistry And Biophysics, 507 (1), 154-162. doi: 10.1016/j.abb.2010.09.009

Configurational assignment of cyclic peroxy metabolites provides an insight into their biosynthesis: Isolation of plakortolides, seco-plakortolides, and plakortones from the Australian marine sponge Plakinastrella clathrata

Yong, Ken W. L., De Voss, James J., Hooper, John N. A. and Garson, Mary J. (2011). Configurational assignment of cyclic peroxy metabolites provides an insight into their biosynthesis: Isolation of plakortolides, seco-plakortolides, and plakortones from the Australian marine sponge Plakinastrella clathrata. Journal of Natural Products, 74 (2), 194-207. doi: 10.1021/np100620x

Biosynthesis of the spiroacetal suite in bactrocera tryoni

Booth, Yvonne K., Kitching, William and De Voss, James J. (2011). Biosynthesis of the spiroacetal suite in bactrocera tryoni. ChemBioChem, 12 (1), 155-172. doi: 10.1002/cbic.201000481

Corrigendum: Steroidal Saponins Isolated from an Australian Yam (Dioscorea sp.)

Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Corrigendum: Steroidal Saponins Isolated from an Australian Yam (Dioscorea sp.). Australian Journal of Chemistry, 64 (11), 1540-1540. doi: 10.1071/CH11056_CO

Erratum: Steroidal saponins isolated from an Australian Yam (Dioscorea sp.) (Australian Journal of Chemistry (2011) 64:5 (545-549))

Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Erratum: Steroidal saponins isolated from an Australian Yam (Dioscorea sp.) (Australian Journal of Chemistry (2011) 64:5 (545-549)). Australian Journal of Chemistry, 64 (11). doi: 10.1071/CH11056-CO

Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata

Hayes, PY, Chow, S, Somerville, MJ, Fletcher, MT and De Voss, JJ (2010). Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata. Journal of Natural Products, 73 (11), 1907-1913. doi: 10.1021/np1005746

Synthesis of the sponge-derived plakortone series of bioactive compounds

Hayes, PY, Chow, S, Rahm, F, Bernhardt, PV, De Voss, JJ and Kitching, W (2010). Synthesis of the sponge-derived plakortone series of bioactive compounds. Journal of Organic Chemistry, 75 (19), 6489-6501. doi: 10.1021/jo101224w

Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner

Hawkes, David B., Slessor, Kate E., Bernhardt, Paul V. and De Voss, James J. (2010). Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner. ChemBioChem, 11 (8), 1107-1114. doi: 10.1002/cbic.201000119

Cineole biodegradation: Molecular cloning, expression and characterisation of (1R)-6beta - hydroxycineole dehydrogenase from Citrobacter braakii

Slessor, Kate E., Stok, Jeanette E., Cavaignac, Sonia M., Hawkes, David B., Ghasemi, Younes and De Voss, James J. (2010). Cineole biodegradation: Molecular cloning, expression and characterisation of (1R)-6beta - hydroxycineole dehydrogenase from Citrobacter braakii. Bioorganic Chemistry, 38 (2), 81-86. doi: 10.1016/j.bioorg.2009.12.003

Ptesculentoside, a novel norsesquiterpene glucoside from the Australian bracken fern Pteridium esculentum

Fletcher, Mary T., Hayes, Patricia Y., Somerville, Michael, J. and De Voss, James J. (2010). Ptesculentoside, a novel norsesquiterpene glucoside from the Australian bracken fern Pteridium esculentum. Tetrahedron Letters, 51 (15), 1997-1999. doi: 10.1016/j.tetlet.2010.02.032

Spiroacetal biosynthesis in fruit flies is complex: distinguishable origins of the same major spiroacetal released by different Bactrocera spp.

Schwartz, Brett D., Booth, Yvonne K., Fletcher, Mary T., Kitching, William and De Voss, James J. (2010). Spiroacetal biosynthesis in fruit flies is complex: distinguishable origins of the same major spiroacetal released by different Bactrocera spp.. Chemical Communications, 46 (9), 1526-1528. doi: 10.1039/b917977a

Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata

Hayes, Patricia Y., Chow, Sharon, Somerville, Michael J., De Voss, James J. and Fletcher, Mary T. (2009). Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata. Journal of Natural Products, 72 (12), 2081-2083. doi: 10.1021/np900573k

Biosynthesis of insect spiroacetals

Booth, Yvonne K., Kitching, William and De Voss, James J. (2009). Biosynthesis of insect spiroacetals. Natural Product Reports, 26 (4), 490-525. doi: 10.1039/b717392j

Steroidal saponins from the roots of Trillium erectum (Beth root)

Hayes, Patricia Y., Lehmann, Reg, Penman, Kerry, Kitching, William and De Voss, James J. (2009). Steroidal saponins from the roots of Trillium erectum (Beth root). Phytochemistry, 70 (1), 105-113. doi: 10.1016/j.phytochem.2008.10.019

Spiroacetal biosynthesis in insects from Diptera to Hymenoptera: The Giant Ichneumon wasp Megarhyssa nortoni nortoni Cresson

Schwartz, Brett D., Moore, Christopher J., Rahm, Frederik, Hayes, Patricia Y., Kitching, William and De Voss, James J. (2008). Spiroacetal biosynthesis in insects from Diptera to Hymenoptera: The Giant Ichneumon wasp Megarhyssa nortoni nortoni Cresson. Journal of the American Chemical Society, 130 (44), 14853-14860. doi: 10.1021/ja8036433

Re-engineering of CYP2C9 to probe acid-base substrate selectivity

Tai, Guoying, Dickmann, Leslie J., Matovic, Nicholas, DeVoss, James J., Gillam, Elizabeth M. J. and Rettie, Allan E. (2008). Re-engineering of CYP2C9 to probe acid-base substrate selectivity. Drug Metabolism and Disposition, 36 (10), 1992-1997. doi: 10.1124/dmd.108.022186

The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in P450cin

Meharenna, YT, Slessor, KE, Cavaignac, SM, Poulos, TL and De Voss, JJ (2008). The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in P450cin. Journal of Biological Chemistry, 283 (16), 10804-10812. doi: 10.1074/jbc.M709722200

Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application

Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2008). Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application. Journal of Biomolecular Screening, 13 (2), 135-141. doi: 10.1177/1087057107312780

Steroidal saponins from the roots of Asparagus racemosus

Hayes, P., Jahidin, A., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. (2008). Steroidal saponins from the roots of Asparagus racemosus. Phytochemistry, 69 (3), 796-804. doi: 10.1016/j.phytochem.2007.09.001

The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant

Cryle, Max J. and De Voss, James J. (2008). The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant. ChemBioChem, 9 (2), 261-266. doi: 10.1002/cbic.200700537

Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam)

Hayes, Patricia Y., Lambert, Lynette K., Lehmann, Reg, Penman, Kerry, Kitching, William and De Voss, James J. (2007). Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam). Magnetic Resonance in Chemistry, 45 (11), 1001-1005. doi: 10.1002/mrc.2071

A shuffled CYP1A library shows both structural integrity and functional diversity

Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007). A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 (12), 2177-2185. doi: 10.1124/dmd.107.017939

A shuffled CYP2C library with a high degree of structural integrity and functional versatility

Huang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007). A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 (2), 193-205. doi: 10.1016/j.abb.2007.08.023

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans

Kim, Donghak, Cryle, Max J., De Voss, James J. and de Montellano, Paul R. Ortiz (2007). Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Archives of Biochemistry And Biophysics, 464 (2), 213-220. doi: 10.1016/j.abb.2007.02.032

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant

Cryle, Max J. and De Voss, James J. (2007). Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant. Tetrahedron: Asymmetry, 18 (4), 547-551. doi: 10.1016/j.tetasy.2007.01.034

Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly)

Booth, Yvonne K., Hayes, Patricia Y., Moore, Christopher J., Lambert, Lynette K., Kitching, William and De Voss, James J. (2007). Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly). Organic & Biomolecular Chemistry, 5 (7), 1111-1117. doi: 10.1039/b701833a

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling

Rosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J. and Gillam, Elizabeth M.J. (2007). Extending the diversity of cytochrome P450 enzymes by DNA family shuffling. Gene, 395 (1-2), 40-48. doi: 10.1016/j.gene.2007.01.031

Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.

Matovic, N., Matthias, A., Gertsch, J., Raduner, S., Bone, K. M., Lehmann, R. P. and DeVoss, J. J. (2007). Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.. Organic & Biomolecular Chemistry, 5 (1), 169-174. doi: 10.1039/b615487e

The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)

Cryle, Max J., Matovic, Nick J. and De Voss, James J. (2007). The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3). Tetrahedron Letters, 48 (1), 133-136. doi: 10.1016/j.tetlet.2006.10.136

Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?

Cryle, Max J. and De Voss, James J. (2006). Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?. Angewandte Chemie International Edition, 45 (48), 8221-8223. doi: 10.1002/anie.200603411

A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly)

Booth, Yvonne K., Schwartz, Brett D., Fletcher, Mary T., Lambert, Lynette K., Kitching, William and De Voss, James J. (2006). A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly). Chemical Communications (38), 3975-3977. doi: 10.1039/b611953k

Are branched chain fatty acids the natural substrates for P450(BM3)?

Cryle, Max J., Espinoza, Rocio D., Smith, Sarah J., Matovic, Nicholas J. and De Voss, James J. (2006). Are branched chain fatty acids the natural substrates for P450(BM3)?. Chemical Communications (22), 2353-2355. doi: 10.1039/b601202g

Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus

Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus. Tetrahedron Letters, 47 (-), 8683-8687. doi: 10.1016/j.tetlet.2006.10.030

Bilberry adulteration using the food dye amaranth

Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J. J., Stuthe, J. M. U., Bone, K. M. and Lehmann, R. P. (2006). Bilberry adulteration using the food dye amaranth. Journal of Agricultural and Food Chemistry, 54 (19), 7378-7382. doi: 10.1021/jf061387d

Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites

Avent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006). Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 (7), 914-920. doi: 10.1021/tx0600090

RP-HPLC detection of a sulphiting-induced artefact from paeoniflorin in dried roots of Paeonia lactiflora

Hayes, P. Y., Lehmann, R., Penman, K., Bone, K. M., Kitching, W. and De Voss, J. J. (2006). RP-HPLC detection of a sulphiting-induced artefact from paeoniflorin in dried roots of Paeonia lactiflora. Phytochemical Analysis, 17 (4), 251-254. doi: 10.1002/pca.911

Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus

Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus. Tetrahedron Letters, 47 (39), 6965-6969. doi: 10.1016/j.tetlet.2006.07.121

Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes

Matthias, A., Gillam, E. M. J., Penman, K. G., Matovic, N. J., Bone, K. M., De Voss, J. J. and Lehmann, R. P. (2005). Cytochrome P450 enzyme-mediated degradation of Echinacea alkylamides in human liver microsomes. Chemico-biological Interactions, 155 (1-2), 62-70. doi: 10.1016/j.cbi.2005.04.003

Calibration of the channel that determines the omega-hydroxylation regiospecificity of cytochrome P4504A1 - Catalytic oxidation of 12-halododecanoic acids

He, X., Cryle, M. J., De Voss, J. J. and de Montellano, P. R. O. (2005). Calibration of the channel that determines the omega-hydroxylation regiospecificity of cytochrome P4504A1 - Catalytic oxidation of 12-halododecanoic acids. Journal of Biological Chemistry, 280 (24), 22697-22705. doi: 10.1074/jbc.M502632200

Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450

Cryle, Max J., Ortiz de Montellano, Paul R. and De Voss, James J. (2005). Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450. Journal of Organic Chemistry, 70 (7), 2455-2469. doi: 10.1021/jo047985d

Flexible synthesis of enantiomerically pure 2,8-dialkyl-1,7-dioxaspiro[5.5]undecanes and 2,7-dialkyl-1,6-dioxaspiro[4.5]decanes from propargylic and homopropargylic alcohols

Schwartz, B. D., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Flexible synthesis of enantiomerically pure 2,8-dialkyl-1,7-dioxaspiro[5.5]undecanes and 2,7-dialkyl-1,6-dioxaspiro[4.5]decanes from propargylic and homopropargylic alcohols. Journal Of Organic Chemistry, 70 (8), 3054-3065. doi: 10.1021/jo0477547

Sodium paeoniflorin sulfonate, a process derived artefact from paeoniflorin

Hayes, P. Y. N., Lehmann, R. P., Penman, K. G., Kitching, W. and De Voss, J. J. (2005). Sodium paeoniflorin sulfonate, a process derived artefact from paeoniflorin. Tetrahedron Letters, 46 (15), 2615-2618. doi: 10.1016/j.tetlet.2005.02.082

Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly)

Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Mazomenos, B. E., Konstantopoulou, M. A., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly). Organic Letters, 7 (6), 1173-1176. doi: 10.1021/ol050143w

A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites

Fletcher, Mary T., Wood, Barry J., Schwartz, Brett D., Rahm, Fredrik, Lambert, Lynette K., Brereton, Ian M., Moore, Christopher J., De Voss, James J. and Kitching, William (2004). A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites. Arkivoc, 2004 (x), 109-117. doi: 10.3998/ark.5550190.0005.a12

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations

Cryle, Max J., Stuthe, Julia M. U., Ortiz de Montellano, Paul R. and De Voss, James J. (2004). Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations. Chemical Communications, 10 (5), 512-513. doi: 10.1039/b315911f

Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9)

Davies, C., Witham, K., Scott, J. R., Pearson, A., De Voss, J. J., Graham, S. E. and Gillam, E. M. J. (2004). Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9). Drug Metabolism and Disposition, 32 (4), 431-436. doi: 10.1124/dmd.32.4.431

Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1)

Cryle, Max J. and De Voss, James J. (2004). Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1). Chemical Communications, 2004 (1), 86-87. doi: 10.1039/b311652b

Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam

Meharenna, Y. T., Li, H. Y., Hawkes, D. B., Pearson, A. G., De Voss, J. and Poulos, T. L. (2004). Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. Biochemistry, 43 (29), 9487-9494. doi: 10.1021/bi049293p

Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model

Matthias, A., Blanchfield, J. T., Penman, K. G., Toth, I., Lang, C. S., De Voss, J. J. and Lehmann, R. P. (2004). Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model. Journal of Clinical Pharmacy And Therapeutics, 29 (1), 7-13. doi: 10.1046/j.1365-2710.2003.00530.x

Electrochemistry of P450cin: new insights into P450 electron transfer

Aguey-Zinsou, Kondo-François, Bernhardt, Paul V., De Voss, James J. and Slessor, Kate E. (2003). Electrochemistry of P450cin: new insights into P450 electron transfer. Chemical Communications, 3 (3), 418-419. doi: 10.1039/b211567k

Insect chemistry and chirality

Hayes, Patricia Y., Fletcher, Mary T., Chow, Sharon, McGrath, Matthew J., Tu, Yong Q., Zhang, Hesheng, Hungerford, Natasha L., McErlean, Christopher S. P., Stok, Jeannette E., Moore, Christopher J., De Voss, James J. and Kitching, William (2003). Insect chemistry and chirality. Chirality, 15 (S1), S116-S127. doi: 10.1002/chir.10273

Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

Cryle, M. J., Matovic, N. J. and De Voss, J. J. (2003). Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids. Organic Letters, 5 (18), 3341-3344. doi: 10.1021/ol035254e

Reactions catalyzed by bacterial cytochromes P450

Cryle, M. J., Stok, J. E. and De Voss, J. J. (2003). Reactions catalyzed by bacterial cytochromes P450. Australian Journal of Chemistry, 56 (8), 749-762. doi: 10.1071/CH03040

[18O]-Oxygen incorporation reveals novel pathways in spiroacetal biosynthesis by Bactrocera cacuminata and B. cucumis

Fletcher, Mary T., Wood, Barry J., Brereton, Ian M., Stok, Jeanette E., De Voss, James J. and Kitching, William (2002). [18O]-Oxygen incorporation reveals novel pathways in spiroacetal biosynthesis by Bactrocera cacuminata and B. cucumis. Journal of the American Chemical Society, 124 (26), 7666-7667. doi: 10.1021/ja026215l

Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization

Hawkes, David B., Adams, Gregory W., Burlingame, Alma L., de Montellano, Paul R. Ortiz and De Voss, James J. (2002). Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. Journal of Biological Chemistry, 277 (31), 27725-27732. doi: 10.1074/jbc.M203382200

Medium ring ethers by ring expansion-ring contraction: Synthesis of lauthisan

Coster, M. J. and De Voss, J. J. (2002). Medium ring ethers by ring expansion-ring contraction: Synthesis of lauthisan. Organic Letters, 4 (18), 3047-3050. doi: 10.1021/ol0262946

Monooxygenase stereoselectivity in the biosynthesis of stereoisomeric spiroacetals in the cucumber fly, Bactrocera cucumis

McErlean, Christopher S. P., Fletcher, Mary T., Wood, Barry J., De Voss, James J. and Kitching, William (2002). Monooxygenase stereoselectivity in the biosynthesis of stereoisomeric spiroacetals in the cucumber fly, Bactrocera cucumis. Organic Letters, 4 (16), 2775-2778. doi: 10.1021/ol0263090

Oxidizing species in the mechanism of cytochrome P450

de Montellano, P. R. O. and De Voss, J. J. (2002). Oxidizing species in the mechanism of cytochrome P450. Natural Product Reports, 19 (4), 477-493. doi: 10.1039/b101297p

Sex pheromone biosynthesis in the female olive fruit-fly. Double labelling from [O-18(2)]-dioxygen into 1,7-dioxaspiro[5.5]undecane

Fletcher, Mary T., Mazomenos, Basilis E., Georgakopoulos, John H., Konstantopoulou, Maria A., Wood, Barry J., De Voss, James J. and Kitching, William (2002). Sex pheromone biosynthesis in the female olive fruit-fly. Double labelling from [O-18(2)]-dioxygen into 1,7-dioxaspiro[5.5]undecane. Chemical Communications, 12 (12), 1302-1303. doi: 10.1039/b202697j

Carbon hydroxylation of alkyltetrahydropyranols: A paradigm for spiroacetal biosynthesis in Bactrocera sp.

Stok, J. E., Lang, C. S., Schwartz, B. D., Fletcher, M. T., Kitching, W. and De Voss, J. J. (2001). Carbon hydroxylation of alkyltetrahydropyranols: A paradigm for spiroacetal biosynthesis in Bactrocera sp.. Organic Letters, 3 (3), 397-400. doi: 10.1021/ol0069047

Identification and total synthesis of novel fatty acids from the siphonarid limpet Siphonaria denticulata

Carballeira, N. M., Cruz, H., Hill, C. A., De Voss, J. J. and Garson, M. (2001). Identification and total synthesis of novel fatty acids from the siphonarid limpet Siphonaria denticulata. Journal of Natural Products, 64 (11), 1426-1429. doi: 10.1021/np010307r

Structure and absolute configuration of mycobactin J

Schwartz, B. D. and De Voss, J. J. (2001). Structure and absolute configuration of mycobactin J. Tetrahedron Letters, 42 (21), 3653-3655. doi: 10.1016/S0040-4039(01)00531-7

Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis

Stok, J. and De Voss, J. J. (2000). Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis. Archives of Biochemistry And Biophysics, 384 (2), 351-360. doi: 10.1006/abbi.2000.2067

Oxidation of Indole by Cytochrome P450 Enzymes

Gillam, E. M. J., Notley, L. M., Cai, H. L., De Voss, J. J. and Guengerich, F. P. (2000). Oxidation of Indole by Cytochrome P450 Enzymes. Biochemistry, 39 (45), 13817-13824. doi: 10.1021/bi001229u

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

De Voss, J. J., Rutter, K., Schroeder, B. G., Su, H., Zhu, Y. Q. and Barry, C. E. (2000). The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proceedings of The National Academy of Sciences of The United States of America, 97 (3), 1252-1257. doi: 10.1073/pnas.97.3.1252

Iron acquisition and metabolism by mycobacteria

De Voss, James J., Rutter, Kerry, Schroeder, Benjamin G. and Barry, Clifton E. (1999). Iron acquisition and metabolism by mycobacteria. Journal of Bacteriology, 181 (15), 4443-4451. doi: 10.1128/jb.181.15.4443-4451.1999

Formation of indigo by recombinant mammalian cytochrome P450

Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999). Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2), 469-472. doi: 10.1006/bbrc.1999.1702

Biogenesis of sex pheromones in the female olive fruit-fly

Hungerford, Natasha L., Mazomenos, Basilis E., Konstantopoulou, Maria A., Krokos, Fragoulis D., Haniotakis, George E., Hubener, Achim, Fletcher, Mary T., Moore, Christopher J., DeVoss, James J. and Kitching, William (1998). Biogenesis of sex pheromones in the female olive fruit-fly. Chemical Communications, 29 (8), 863-864. doi: 10.1039/a800691a

Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation

Munns, Andrew J., De Voss, James J., Hooper, Wayne D., Dickinson, Ronald G. and Gillam, Elizabeth M. J. (1997). Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation. Chemical Research In Toxicology, 10 (9), 1049-1058. doi: 10.1021/tx9700836

The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease

Rutenber, Earl E., De Voss, James J., Hoffman, Lucas, Stroud, Robert M., Lee, Kwan H., Alvarez, Juan, McPhee, Fiona, Craik, Charles and Ortiz De Montellano, Paul R. (1997). The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorganic and Medicinal Chemistry, 5 (7), 1311-1320. doi: 10.1016/S0968-0896(97)00078-3

Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant

De Voss, James J., Sibbesen, Ole, Zhang, Zhoupeng and Ortiz De Montellano, Paul R. (1997). Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant. Journal of the American Chemical Society, 119 (24), 5489-5498. doi: 10.1021/ja970349v

Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins

De Voss, James J., Leeper, Finian J. and Battersby, Alan R. (1997). Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins. Journal of the Chemical Society - Perkin Transactions 1 (8), 1105-1116. doi: 10.1039/a607852d

Purification and characterisation of P450Biol

De Voss J.J. and Stok J.E. (1997). Purification and characterisation of P450Biol. FASEB Journal, 11 (9)

Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system

Sibbesen, Ole, De Voss, James J. and Ortiz de Montellano, Paul R. (1996). Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system. Journal of Biological Chemistry, 271 (37), 22462-22469. doi: 10.1074/jbc.271.37.22462

Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups

Yu, Z., Caldera, P., McPhee, F., De Voss, J. J., Jones, P. R., Burlingame, A. L., Kuntz, I. D., Craik, C. S. and Ortiz De Montellano, P. R. (1996). Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups. Journal of the American Chemical Society, 118 (25), 5846-5856. doi: 10.1021/ja954069w

Substrate docking algorithms and the predicition of substrate specificity

De Voss, James J. and Ortiz De Montellano, Paul R. (1996). Substrate docking algorithms and the predicition of substrate specificity. Methods in Enzymology, 272, 336-347.

Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins

Brown Jr., R. S., Lomri, N., De Voss, J., Rahmaoui, C. M., Xie, M. H., Hua, T., Lidofsky, S. D. and Scharschmidt, B. F. (1995). Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins. Proceedings of the National Academy of Sciences of the United States of America, 92 (12), 5421-5425. doi: 10.1073/pnas.92.12.5421

Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam

De Voss, James J. and Ortiz de Montellano, Paul R. (1995). Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam. Journal of the American Chemical Society, 117 (14), 4185-4186. doi: 10.1021/ja00119a041

Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol

Lee, Kwan Hee, McPhee, Fiona, DeVoss, James J., Craik, Charles S. and de Montellano, Paul R. Ortiz (1994). Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol. Journal of Organic Chemistry, 59 (21), 6194-6199. doi: 10.1021/jo00100a021

General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides

De Voss, James J., Hangeland, Jon J. and Townsend, Craig A. (1994). General Approach to the Synthesis of Specifically Deuterium-Labeled Nucleosides. Journal of Organic Chemistry, 59 (10), 2715-2723. doi: 10.1021/jo00089a013

In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases

Salto, Rafael, Babé, Lilia M., Li, Jia, Rosé, Jason R., Yu, Zhonghua, Burlingame, Aima, De Voss, James J., Sui, Zhihua, Ortiz De Montellano, Paul and Craik, Charles S. (1994). In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases. Journal of Biological Chemistry, 269 (14), 10691-10698.

Haloperidol-Based Irreversible Inhibitors of the HIV-1 and HIV-2 Proteases

De Voss, James J., Sui, Zhihua, DeCamp, Dianne L., Salto, Rafael, Babé, Lilia M., Craik, Charles S. and de Montellano, Paul R. Ortiz (1994). Haloperidol-Based Irreversible Inhibitors of the HIV-1 and HIV-2 Proteases. Journal of Medicinal Chemistry, 37 (5), 665-673. doi: 10.1021/jm00031a017

Synthesis of medium size rings containing oxygen and sulfur by ring expansion of halodioxolanes, dioxanes and oxathiolanes

De Voss, James J. and Sui, Zhihua (1994). Synthesis of medium size rings containing oxygen and sulfur by ring expansion of halodioxolanes, dioxanes and oxathiolanes. Tetrahedron Letters, 35 (1), 49-52. doi: 10.1016/0040-4039(94)88159-6

Synthesis of haloperidol ethanedithioketal HIV-1 protease inhibitors: Magnesium chloride facilitated addition of Grignard reagents

Sui, Z., De Voss, J. J., DeCamp, D. L., Li, J., Craik, C. S. and Ortiz De Montellano, P. R. (1993). Synthesis of haloperidol ethanedithioketal HIV-1 protease inhibitors: Magnesium chloride facilitated addition of Grignard reagents. Synthesis (8), 803-808.

Ring Expansion of Halo Dithiolanes and Dithianes: A Facile Synthesis of Medium-Ring Dithiacycloalkenes

Sui, Zhihua, Furth, Paul S. and De Voss, James J. (1992). Ring Expansion of Halo Dithiolanes and Dithianes: A Facile Synthesis of Medium-Ring Dithiacycloalkenes. Journal of Organic Chemistry, 57 (24), 6658-6662. doi: 10.1021/jo00050a058

Mercury(II)-mediated routes to some side-chain functionalised 1,7-dioxaspiro[5.5]undecanes. Applications of Luche-Barbier chemoselective addition to ketoaldehydes

Devoss, JJ, Jamie, JF, Blanchfield, JT, Fletcher, MT, Oshea, MG and Kitching, W (1991). Mercury(II)-mediated routes to some side-chain functionalised 1,7-dioxaspiro[5.5]undecanes. Applications of Luche-Barbier chemoselective addition to ketoaldehydes. Tetrahedron, 47 (10-11), 1985-1996. doi: 10.1016/S0040-4020(01)96110-1

Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to dna cleavage

De Voss, James J., Hangeland, Jon J. and Townsend, Craig A. (1990). Characterization of the in vitro cyclization chemistry of calicheamicin and its relation to dna cleavage. Journal of the American Chemical Society, 112 (11), 4554-4556. doi: 10.1021/ja00167a069

Site-Specific Atom Transfer from DNA to a Bound Ligand Defines the Geometry of a DNA-Calicheamicin ϒ11 Complex

De Voss, James J., Townsend, Craig A., Ding, Wei Dong, Morton, George O., Ellestad, George A., Zein, Nada, Tabor, Alethea B. and Schreiber, Stuart L. (1990). Site-Specific Atom Transfer from DNA to a Bound Ligand Defines the Geometry of a DNA-Calicheamicin ϒ11 Complex. Journal of the American Chemical Society, 112 (26), 9669-9670. doi: 10.1021/ja00182a053

1‐Mesyl‐4‐[2‐(methoxycarbonyl)ethyl]‐3‐(methoxycarbonyl)methyl‐N,N‐dimethylpyrrole‐2‐carboxamide

Allen, F. H., Battersby, A. R., De Voss, J. J., Doyle, M. J. and Raithby, P. R. (1989). 1‐Mesyl‐4‐[2‐(methoxycarbonyl)ethyl]‐3‐(methoxycarbonyl)methyl‐N,N‐dimethylpyrrole‐2‐carboxamide. Acta Crystallographica Section C, 45 (4), 692-694. doi: 10.1107/S0108270188012740

Spiroacetals from dienones and hydroxyenones by mercury(II) cyclisation

Kitching, William, Lewis, Judith A., Fletcher, Mary T., De Voss, James J., Drew, Richard A.I. and Moore, Christopher J. (1986). Spiroacetals from dienones and hydroxyenones by mercury(II) cyclisation. Journal of the Chemical Society. Chemical Communications, 1986 (11), 855-856. doi: 10.1039/c39860000855

The Diastereomeric 8, 9-Epoxides of Limonene (The 8, 9-Epoxy-p-menth-1-enes)

Carman R.M., De Voss J.J. and Greenfield K.L. (1985). The Diastereomeric 8, 9-Epoxides of Limonene (The 8, 9-Epoxy-p-menth-1-enes). Australian Journal of Chemistry, 39 (3), 441-446. doi: 10.1071/CH9860441

Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule)

Matheus Carpinelli de Jesus, Natasha Hungerford, Steve Carter, Shalona Anuj, Joanne Blanchfield, James De Voss and Mary Fletcher (2018). Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule). QMSS 2018 – 3rd Queensland Mass Spectrometry Symposium, QUT, Brisbane, 6-7 December 2018.

Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia

Carpinelli de Jesus, M., Hungerford, N. L., Carter, S. J., Anuj, S. R., De Voss, J. J., Blanchfield, J. T. and Fletcher, M. T. (2018). Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia. 10th International Symposium of Poisonous Plants (ISOPP10), St George, Utah, United States, 16-20 September 2018.

P450 catalysed dehydrogenation

Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2017). P450 catalysed dehydrogenation. Berlin, Germany: Walter de Gruyter GmbH. doi: 10.1515/pac-2016-1216

An assessment of the utility of DNA barcoding in the quality control of herbal raw materials, extracts and finished products

Wohlmuth, H., Leach, D., McGrath, K., Gordon, L., Mouatt, P. and De Voss, J. (2016). An assessment of the utility of DNA barcoding in the quality control of herbal raw materials, extracts and finished products. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen, Denmark, 24 - 27 July 2016. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0036-1597032

Establishing compositional guidelines for flavonoids and saponins in Gynostemma pentaphyllum

Leach, D., Ahmed, I., De Voss, J. and Wohlmuth, H. (2016). Establishing compositional guidelines for flavonoids and saponins in Gynostemma pentaphyllum. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, 24 - 27 July 2016. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0036-1597033

Spectroscopic insights into Cyclic Polyketide Peroxides: New Plakortolides from Plakinastrella clathrata Kirkpatrick, 1900

Yong, Ken W.L., De Voss, James J., Hooper, John N.A. and Garson, Mary J. (2011). Spectroscopic insights into Cyclic Polyketide Peroxides: New Plakortolides from Plakinastrella clathrata Kirkpatrick, 1900. 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity, Brisbane, Australia, 10 - 15 July 2011. Research Triangle Park, United States: International Union of Pure and Applied Chemistry.

Steroidal saponins isolated from an Australian Yam Dioscorea sp.

Challinor, Victoria L., Smith, David M. and De Voss, James J. (2011). Steroidal saponins isolated from an Australian Yam Dioscorea sp.. Collingwood, VIC, Australia: C S I R O Publishing. doi: 10.1071/CH11056

Using NMR-based methods to assign the stereochemistry of bioactive cyclic peroxide metabolites

Yong, Ken W., Lambert, Lynette K., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of bioactive cyclic peroxide metabolites. NZ Institute of Chemistry Conference (NZIC, 2011), Hamilton, N.Z., 27 November-1 December 2011. Harewood, Christchurch, N.Z.: NZ Institute of Chemistry.

Using NMR-based methods to assign the stereochemistry of natural products

Yong, Ken W.L., De Voss, James J. and Garson, Mary J. (2011). Using NMR-based methods to assign the stereochemistry of natural products. International Congress for Innovation in Chemistry (VII, PERCH-CIC, 2011), Pattaya, Thailand, 4-7 May 2011. Bangkok, Thailand: Centre of Excellence for Innovation in Chemistry.

Spectroscopic insight into cyclic polyketide peroxides: Plakortolide F and 6-epiplakortolide F

Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: Plakortolide F and 6-epiplakortolide F. 5th Annual Symposium on Marine Natural Products and Drug Discovery, Pohan, South Korea, September 2010.

Spectroscopic insight into cyclic polyketide peroxides: plakortolide F and 6-epiplakortolide F

Yong, K. W. L., De Voss, J. J., Hooper, J. N. A. and Garson, M. J. (2010). Spectroscopic insight into cyclic polyketide peroxides: plakortolide F and 6-epiplakortolide F. 6th Annual SCMB Research Students Symposium, Brisbane, QLD, Austalia, 25 November 2010.

Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations

Singh, Arti, Cryle, M., Hunter, D,, Stok, J. and De Voss, J. (2009). Cytochrome P450-mediated fatty acid oxidation: Mechanistic investigations. ICCC2009: 16th International Conference on Cytochrome P450. Biochemistry, Biophysics, Biotechnology, Nago, Okinawa, Japan, 21-25 June 2009. Bologna, Italy: Medimond S.r.l..

NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide

Penman, K., Bone, K.M., Hayes, P.C., De Voss, J., Agarwal, A., Murali, B, Mundkinajeddu, D., Mayachari, A., Shenoy, R. and Lehmann, R. P. (2007). NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide. 55th International Congress & Annual Meeting of the Society for Medicinal Plant Research, Karl Franzens University, Graz, Austria, 2-6 September, 2007. Stuttgart, Germany: Thieme.

Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan

De Voss, J. (2006). Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan. London: Current Drugs.

Bilberry adulteration using the food dye amaranth

Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J J, Stuthe, J. M., Bone, K. M. and Lehmann, R P (2006). Bilberry adulteration using the food dye amaranth. RACI Natural Products Group Symposium, Wollongong, 29 Sept, 2006.

Chemical constituents of Chamaelirium luteum

Stuthe, J. M., Lambert, L. K., Lehmann, R P, Kitching, W and De Voss, J J (2006). Chemical constituents of Chamaelirium luteum. ANZMAG, Murramarang, NSW, 13-16 Feb, 2006.

Dna family shuffling of mammalian P450s from CYP2A and CYP3A subfamilies

Gillam, Elizabeth M. J., Johnston, W. A., DeVoss, J. J., Soucek, Pavel and Hunter, D. J. B. (2006). Dna family shuffling of mammalian P450s from CYP2A and CYP3A subfamilies. 14th North American Meeting of the International-Society-for-the-Study-of-Xenobiotics, Rio Grande, Puerto Rico, 22-26 October 2006. Philadelphia, PA USA: Taylor & Francis.

Insect spiroacetal biosynthesis

De Voss, J J (2006). Insect spiroacetal biosynthesis. Biodiversity- IUPAC International Conference, Kyoto, 23-28 July, 2006.

Bioavailability of Echinacea Constituents: Caco-2 Monolayers and Pharmacokinetics of the Alkylamides and Caffeic Acid Conjugates

Matthias, Anita, Penman, Kerry G., Matovic, Nick J., Bone, Kerry M., De Voss, James J. and Lehmann, Reg P. (2005). Bioavailability of Echinacea Constituents: Caco-2 Monolayers and Pharmacokinetics of the Alkylamides and Caffeic Acid Conjugates. Basel, Switzerland: Molecules/Molecular Diversity Preservation International. doi: 10.3390/10101242

Alternative reactions catalysed by cytochrome P450cin

Slessor, K., Schloendorn, J. and De Voss, J. J. (2005). Alternative reactions catalysed by cytochrome P450cin. Connect 2005, Sydney, 3-7 July, 2005.

C-C bond cleavaged reactions catalysed by cytochrome P450

Slessor, K. and De Voss, J. J. (2005). C-C bond cleavaged reactions catalysed by cytochrome P450. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 25 Nov, 2005.

Cyclopropyl containing fatty acids as probes of cytochrome P450

De Voss, J. J. (2005). Cyclopropyl containing fatty acids as probes of cytochrome P450. Prof Michael Paddon-Rowe Symposium, Sydney, 25 Feb, 2005.

Cytochrome P450cin - alternative reactions with alternative substrates

Farlow, A. J. and De Voss, J. J. (2005). Cytochrome P450cin - alternative reactions with alternative substrates. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 25 Nov, 2005.

Modified fatty acids as cytochrome P450 substrates

De Voss, J. J., Cryle, M. J. and Hayes, P. Y. N. (2005). Modified fatty acids as cytochrome P450 substrates. 14th International Conference on Cytochromes P450, Dallas, 31 May - 5 June, 2005.

Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly)

Booth, Y. K., Schwartz, B. D., Fletcher, M. T., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly). 14th European Symposium in Organic Chemistry, Helsinki, 4-8 July, 2005.

Synthesis of polyunsaturated alkyl amide constituents from Echinacea

Matovic, N. J. and De Voss, J. J. (2005). Synthesis of polyunsaturated alkyl amide constituents from Echinacea. 14th European Symposium in Organic Chemistry, Helsinki, 4-8 July, 2005.

Chemical constituents of Chamaelirum luteum by NMR

Stuthe, J. M. U., Lambert, L. K., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2004). Chemical constituents of Chamaelirum luteum by NMR. ANZMAG 2004, Barossa Valley, 15-19 Feb, 2004.

Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly)

Booth, Y. K. and De Voss, J. J. (2004). Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly). BBOCS, Brisbane, 26 Nov, 2004.

Is Asn242 important in P450cin catalysis?

Slessor, K. E., Cavaignac, S. M., Hawkes, D. B. and De Voss, J. J. (2004). Is Asn242 important in P450cin catalysis?. 7th International Symposium on Cytochrome P450 Biodiversity &y, Hyogo, Japan, 1-5 Aug, 2004.

NMR elucidation of the products from cationic rearrangement of cyclopropane rings

Cryle, M. J., Stuthe, J. M. U., Lambert, L. K. and De Voss, J. J. (2004). NMR elucidation of the products from cationic rearrangement of cyclopropane rings. ANZMAG 2004, Tanunda, South Australia, 15-19 Feb, 2004.

Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

He, X., Deng, D., Cryle, M. J., De Voss, J. J., Groves, J. and Ortiz de Montellano, P.R. (2004). Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. 3rd Int Congress of Porphyrins and Pthalocyanines, New Orleans, 11-16 July, 2004.

Small molecule probes of cytochrome P450 mechanism

De Voss, J. J., Cryle, M. J. and Ortiz de Montellano, P.R. (2004). Small molecule probes of cytochrome P450 mechanism. 20th RACI Organic Chemistry Meeting, Cairns, 4-8 July, 2004.

The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

Ortiz de Montellano, P. R., He, X., Cryle, M. J. and De Voss, J. J. (2004). The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. ISSX 2004: 7th International Society for Study of Xenobiotics Meeting, Vancouver, 29 August - 2 September, 2004. UK: Informa Healthcare. doi: 10.1081/DMR-200027024

Dioxygen bond activation in P450cin

Slessor, K., Cavaignac, S. M., Hawkes, D. and De Voss, J. J. (2003). Dioxygen bond activation in P450cin. The Brisbane Biological & Organic Chemistry Symposium, Brisbane, 28 Nov, 2003.

Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism

Bernhardt, Paul V., Aguey-Zinsou, Kondo-Francois, De Voss, James J. and Slessor, Kate E. (2003). Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism. 11th International Conference on Biological Inorganic Chemistry, Cairns, Qld, 19-23 July, 2003. New York: Elsevier. doi: 10.1016/S0162-0134(03)80462-2

Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism

Rosic, Nedeljka, Lonhienne, Thierry G.A., DeVoss, James J. and Gillam, Elizabeth M.J. (2003). Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism. 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Dijon, France, 27 April - 1 May, 2003. New York: Marcel Dekker. doi: 10.1081/DMR-120020120

Chemical constitutents of chamaelirium luteum

Stuthe, J. M. U., Fletcher, M. T., Lambert, L. K., Penman, K. G., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2002). Chemical constitutents of chamaelirium luteum. 50th Ann Congress of the Society for Medicinal Plant Research, Barcelona, 8-12 September, 2002.

Elucidation of biosynthetic pathways to the spiroacetals in Australian fruit fly species (Bactrocera sp.)

Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Kitching, W. and De Voss, J. J. (2002). Elucidation of biosynthetic pathways to the spiroacetals in Australian fruit fly species (Bactrocera sp.). Brisbane Biological & Organic Chemistry Symposium, Brisbane, 29 November, 2002.

Mechanism of a C-C bond cleaving enzyme: P450 BioI

De Voss, J. J. (2002). Mechanism of a C-C bond cleaving enzyme: P450 BioI. Cornforth Foundation for Chemistry Symposium, Sydney, 30 September - 1 October, 2002.

P450cin: A new P450 with a novel redox partner

De Voss, J. J. (2002). P450cin: A new P450 with a novel redox partner. 6th Int Symposium on Cytochrome P450, Los Angeles, 20-25 August, 2002.

Synthesis and characterisation of [2,4']-bisthaizolines, [2,4]-bisoxazolines, [4,2'] and [2,4']-thiazolinyloxazolines

Schwartz, B. D. and De Voss, J. J. (2002). Synthesis and characterisation of [2,4']-bisthaizolines, [2,4]-bisoxazolines, [4,2'] and [2,4']-thiazolinyloxazolines. IUPAC 14th International Conference on Organic Synthesis, Christchurch, 14-18 July, 2002.

Elucidation of the mechanism of carbon carbon bond cleavage

Cryle, M.J., Stok, J. and De Voss, J. J. (2001). Elucidation of the mechanism of carbon carbon bond cleavage. IUPAC World Chemistry Congress 2001, Brisbane, July, 2001.

Enantioselective synthesis of labelled serine and cysteine

Lang, C. S. and De Voss, J. J. (2001). Enantioselective synthesis of labelled serine and cysteine. IUPAC World Chemistry Congress 2001, Brisbane, July, 2001.

Expression, purification and preliminary X-ray crystallographic trials of P450cin, an oxidative hemoprotein of Citrobacter braakii

Pearson, A. G., Hawkes, D. B., De Voss, J. J. and Martin, J. L. (2001). Expression, purification and preliminary X-ray crystallographic trials of P450cin, an oxidative hemoprotein of Citrobacter braakii. Crystal 22, Society of Crystallographers in Aust and NZ, Couran Cove, Qld, 7-10 July, 2001.

A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis

Stok, J., Cryle, M. J. and De Voss, J. J. (2000). A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis. BICS III, Brisbane, 30 November, 2000. Australia: Royal Australian Chemical Institute.

Elucidation of the mechanism of action of the cytochrome P450 enzyme BioI

Cryle, M. J., Stok, J. and De Voss, J. J. (2000). Elucidation of the mechanism of action of the cytochrome P450 enzyme BioI. Brisbane Biological and Organic Chemistry Symposium 2000, Griffith University, 27 November, 2000.

Formation of indigo by recombinant mammalian cytochrome P450

Kim, D., Gillam, E. M. J., Aguinaldo, A. M., Notley, L., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., De Voss, J. J. and Guengerich, F. P. (2000). Formation of indigo by recombinant mammalian cytochrome P450. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. USA: The Federation of American Societies for Experimental Biology.

Oxidation of indole by human cytochrome P450 enzymes

Guengerich, F. P., Cai, H., Notley, L., De Voss, J. J. and Gillam, E. M. J. (2000). Oxidation of indole by human cytochrome P450 enzymes. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. BETHESDA: The Federation of American Societies for Experimental Biology.

Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis

Stok, J., De Voss, J. J. and Kitching, W. (1999). Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis. 1st Asia-Pacific Conference on Chemical Ecology, Shanghai, China, 1 -4 November 1999. Shanghai, China: Chinese Academy of Science.

Purification and characterisation of P450

De Voss, J. J. and Stok, J. E. (1997). Purification and characterisation of P450. 1997 Faseb Summer Research Conference On Amyloid, Copper Mountain, Colorado, 13-18 July, 1997. Bethesda, MD: Federation of American Societies for Experimental Biology.