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Analytical and preparative enantioselective chromatography (2008–2009)

Abstract:
The facility will allow analysis of enantiomeric mixtures and the preparative separation of such mixtures 100g scale). It utilises HPLC equipment with two important, costly additions. The column is composed of enantiopure, chiral material and provides the only method for direct separation of enantiomers without prior chemical modification. A laser polarimeter detector concomitantly allows sensitive, specific detection of chiral molecules and determines their optical rotation (uniquely associated with their three dimensional structure). Enantiomer separation is vital in drug development as one enatiomer may be active and the other inactive or even toxic. This equipment is currently unavailable in Australia.
Grant type:
ARC Linkage Infrastructure, Equipment and Facilities
Researchers:

  • Professor James De Voss

    Head of School
    Faculty of Science
    Head of School of Chemistry and Mol
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Craig Williams

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Istvan Toth

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Professor of School of Ph
    School of Pharmacy
    Faculty of Health and Behavioural Sciences

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience

  • Professor Joanne Blanchfield

    Professor and Deputy Head of School
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Director of Teaching and Learning o
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
Australian Research Council