Associate Professor West is a molecular microbiologist, expert in bacterial pathogenesis. He is Head of “Tuberculosis Research” in the School of Chemistry and Molecular Biosciences, University of Queensland. Nick has a particular interest in drug development for TB. His research utilises modern molecular technologies to identify the genetic requirements for Mycobacterium tuberculosis to cause Tuberculosis (TB) with these genetic discoveries translated into novel antibiotic therapies. Research within his group falls largely into one of the following four themes: Essential Gene Identification in M. tuberculosis, Understanding TB Latency, Targeted TB Drug Development and Improving TB Vaccination.
Nick conducted postdoctoral research at the University of Oxford and Imperial College London. Returning to Australia in 2004, he spent several years at Sydney’s Centenary Institute as an Associate Faculty member before relocating to University of Queensland in 2012. In addition to drug development, Nick’s research portfolio includes programmes of vaccine and diagnostic development and testing.
Prendergast, Kelly A., Nagalingam, Gayathri, West, Nicholas P. and Triccas, James A. (2024). Mycobacterium tuberculosis Deficient in PdtaS Cytosolic Histidine Kinase Displays Attenuated Growth and Affords Protective Efficacy against Aerosol M. tuberculosis Infection in Mice. Vaccines, 12 (1) 50, 50. doi: 10.3390/vaccines12010050
Journal Article: seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation
Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333
Journal Article: Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
A Faster Cure for Tuberculosis: Revealing Adjunctive Antimicrobial Solutions
(2023–2027) NHMRC IDEAS Grants
Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
(2021–2024) ARC Discovery Projects
Blocking TB Latency: The Key to Reducing Therapy Duration
(2019–2023) NHMRC Project Grant
(2023) Doctor Philosophy
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Doctor Philosophy
Disseminated Tuberculosis; Defining Pathogen Encoded Mechanisms
(2022) Doctor Philosophy
Ng, Benjamin Y.C., Wee, Eugene J.H., West, Nicholas P. and Trau, Matt (2019). Nucleic Acid Detection of Tuberculosis Via Innovative Point-of-Care Nanotechnologies Targeted for Low Resource Settings. Revolutionizing Tropical Medicine. (pp. 584-599) Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119282686.ch33
Prendergast, Kelly A., Nagalingam, Gayathri, West, Nicholas P. and Triccas, James A. (2024). Mycobacterium tuberculosis Deficient in PdtaS Cytosolic Histidine Kinase Displays Attenuated Growth and Affords Protective Efficacy against Aerosol M. tuberculosis Infection in Mice. Vaccines, 12 (1) 50, 50. doi: 10.3390/vaccines12010050
seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation
Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Mu, Andre, Klare, William P., Baines, Sarah L., Ignatius Pang, C. N., Guérillot, Romain, Harbison-Price, Nichaela, Keller, Nadia, Wilksch, Jonathan, Nhu, Nguyen Thi Khanh, Phan, Minh-Duy, Keller, Bernhard, Nijagal, Brunda, Tull, Dedreia, Dayalan, Saravanan, Chua, Hwa Huat Charlie, Skoneczny, Dominik, Koval, Jason, Hachani, Abderrahman, Shah, Anup D., Neha, Nitika, Jadhav, Snehal, Partridge, Sally R., Cork, Amanda J., Peters, Kate, Bertolla, Olivia, Brouwer, Stephan, Hancock, Steven J., Álvarez-Fraga, Laura, De Oliveira, David M. P. ... Walker, Mark J. (2023). Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria. Nature Communications, 14 (1) 1530, 1-21. doi: 10.1038/s41467-023-37200-w
Discovery of anti‐tubercular analogues of bedaquiline with modified A‐, B‐ and C‐ring subunits
Barbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Priebbenow, Daniel and Baell, Jonathan B. (2023). Discovery of anti‐tubercular analogues of bedaquiline with modified A‐, B‐ and C‐ring subunits. ChemMedChem, 18 (1) e202200533, e202200533. doi: 10.1002/cmdc.202200533
Farr, Dylan C., Tan, Lendl, Furness, Juanelle, Grice, I. Darren, West, Nicholas P. and Houston, Todd A. (2023). Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin. Australian Journal of Chemistry, 76 (11), 812-820. doi: 10.1071/ch23154
Ang, Chee Wei, Lee, Brendon M., Jackson, Colin J., Wang, Yuehong, Franzblau, Scott G., Francisco, Amanda F., Kelly, John M., Bernhardt, Paul V., Tan, Lendl, West, Nicholas P., Sykes, Melissa L., Hinton, Alexandra O., Bolisetti, Raghu, Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A.T. (2022). Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection. Journal of Medicinal Chemistry, 65 (19), 13125-13142. doi: 10.1021/acs.jmedchem.2c00972
Two‐component sensor histidine kinases of Mycobacterium tuberculosis: beacons for niche navigation
Stupar, Miljan, Furness, Juanelle, De Voss, Christopher J., Tan, Lendl and West, Nicholas P. (2022). Two‐component sensor histidine kinases of Mycobacterium tuberculosis: beacons for niche navigation. Molecular Microbiology, 117 (5), 973-985. doi: 10.1111/mmi.14899
Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles
Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807
Macrophage and neutrophil death programs differentially confer resistance to tuberculosis
Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P. and Pellegrini, Marc (2021). Macrophage and neutrophil death programs differentially confer resistance to tuberculosis. Immunity, 54 (8), 1758-1771.e7. doi: 10.1016/j.immuni.2021.06.009
Lin, Xin, Kurz, Julia, Patel, Khushboo, Wun, Shun Jie, Hussein, Waleed, Lonhienne, Thierry, West, Nicholas P., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke William (2021). Discovery of a pyrimidine-dione derivative with potent inhibitory activity against Mycobacterium tuberculosis ketol-acid reductoisomerase. Chemistry: A European Journal, 27 (9) chem.202004665, 3130-3141. doi: 10.1002/chem.202004665
Kandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919
The antimicrobial potential of cannabidiol
Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y
Barbaro, Lisa, Nagalingam, Gayathri, Triccas, James A., Tan, Lendl, West, Nicholas P., Baell, Jonathan B. and Priebbenow, Daniel L. (2021). Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit. RSC Medicinal Chemistry, 12 (6), 943-959. doi: 10.1039/d1md00063b
Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., Christensen, Liv von Voss, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020). GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity. Frontiers in Immunology, 11 601534, 601534. doi: 10.3389/fimmu.2020.601534
Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surface
Awad, Milena M., Hutton, Melanie L., Quek, Adam J., Klare, William P., Mileto, Steven J., Mackin, Kate, Ly, Diane, Oorschot, Viola, Bosnjak, Marijana, Jenkin, Grant, Conroy, Paul J., West, Nick, Fulcher, Alex, Costin, Adam, Day, Christopher J., Jennings, Michael P., Medcalf, Robert L., Sanderson-Smith, Martina, Cordwell, Stuart J., Law, Ruby H.P., Whisstock, James C. and Lyras, Dena (2020). Human plasminogen exacerbates Clostridioides difficile enteric disease and alters the spore surface. Gastroenterology, 159 (4), 1431-1443.e6. doi: 10.1053/j.gastro.2020.06.032
Structures of fungal and plant acetohydroxyacid synthases
Lonhienne, Thierry, Low, Yu Shang, Garcia, Mario D., Croll, Tristan, Gao, Yan, Wang, Quan, Brillault, Lou, Williams, Craig M., Fraser, James A., McGeary, Ross P., West, Nicholas P., Landsberg, Michael J., Rao, Zihe, Schenk, Gerhard and Guddat, Luke W. (2020). Structures of fungal and plant acetohydroxyacid synthases. Nature, 586 (7828), 317-321+. doi: 10.1038/s41586-020-2514-3
Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor
Bayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899
Lee, Brendon M., Harold, Liam K., Almeida, Deepak V., Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M., Hards, Kiel, Pidot, Sacha J., Ahmed, F. Hafna, Mohamed, A. Elaaf, Taylor, Matthew C., West, Nicholas P., Stinear, Timothy P., Greening, Chris, Beatson, Scott A., Nuermberger, Eric L., Cook, Gregory M. and Jackson, Colin J. (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. PLoS Pathogens, 16 (2) e1008287, e1008287. doi: 10.1371/journal.ppat.1008287
Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility
Ang, Chee Wei, Tan, Lendl, Sykes, Melissa L., Abugharbiyeh, Neda, Debnath, Anjan, Reid, Janet C., West, Nicholas P., Avery, Vicky M., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. Journal of Medicinal Chemistry, 63 (24), 15726-15751. doi: 10.1021/acs.jmedchem.0c01372
Serafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh-Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza-Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P. and de Carvalho, Luiz Pedro S. (2019). Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism. Molecular Microbiology, 112 (4) mmi.14362, 1284-1307. doi: 10.1111/mmi.14362
Total synthesis of the antimalarial ascidian natural product albopunctatone
Pullella, Glenn A., Wdowiak, Adam P., Sykes, Melissa L., Lucantoni, Leonardo, Sukhoverkov, Kirill V., Zulfiqar, Bilal, Sobolev, Alexandre N., West, Nicholas P., Mylne, Joshua S., Avery, Vicky M. and Piggott, Matthew J. (2019). Total synthesis of the antimalarial ascidian natural product albopunctatone. Organic Letters, 21 (14), 5519-5523. doi: 10.1021/acs.orglett.9b01838
Jarrad, Angie M., Ang, Chee Wei, Debnath, Anjan, Hahn, Hye Jee, Woods, Kyra, Tan, Lendl, Sykes, Melissa L., Jones, Amy J., Pelingon, Ruby, Butler, Mark S., Avery, Vicky M., West, Nicholas P., Karoli, Tomislav, Blaskovich, Mark A. T. and Cooper, Matthew A. (2018). Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity. Journal of Medicinal Chemistry, 61 (24) acs.jmedchem.8b01578, 11349-11371. doi: 10.1021/acs.jmedchem.8b01578
Eng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018). Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159, 10-22. doi: 10.1016/j.ejmech.2018.09.039
Sun, Hsien-Kuo, Pang, Angel, Farr, Dylan C., Mosaiab, Tamim, Britton, Warwick J., Anoopkumar-Dukie, Shailendra, Grice, I. Darren, Kiefel, Milton J., West, Nick P., Grant, Gary D. and Houston, Todd A. (2018). Thioamide derivative of the potent antitubercular 2-(decylsulfonyl) acetamide is less active against mycobacterium tuberculosis, but a more potent antistaphylococcal agent. Australian Journal of Chemistry, 71 (9), 716-719. doi: 10.1071/CH18206
Tan, Lendl, Strong, Emily J., Woods, Kyra and West, Nicholas P. (2018). Homologous alignment cloning: a rapid, flexible and highly efficient general molecular cloning method. PeerJ, 6 (6) e5146, e5146. doi: 10.7717/peerj.5146
Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis
Strong, Emily J. and West, Nicholas P. (2018). Use of soluble extracellular regions of MmpL (SERoM) as vaccines for tuberculosis. Scientific Reports, 8 (1) 5604, 5604. doi: 10.1038/s41598-018-23893-3
Ashhurst, Anneliese S, Parumasivam, Thaigarajan, Chan, John Gar Yan, Lin, Leon C W, Flórido, Manuela, West, Nicholas P, Chan, Hak-Kim and Britton, Warwick J (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PLoS One, 13 (3) e0194620, e0194620. doi: 10.1371/journal.pone.0194620
Brouwer, Stephan, Cork, Amanda J., Ong, Cheryl-Lynn Y., Barnett, Timothy C., West, Nicholas P., McIver, Kevin S. and Walker, Mark J. (2018). The endopeptidase PepO regulates the SpeB cysteine protease and is essential for the virulence of invasive M1T1 Streptococcus pyogenes. Journal of Bacteriology, 200 (8) e00654-17, e00654-17. doi: 10.1128/JB.00654-17
Phan, Minh-Duy, Nhu, Nguyen Thi Khanh, Achard, Maud E. S., Forde, Brian M., Hong, Kar Wai, Chong, Teik Min, Yin, Wai-Fong, Chan, Kok-Gan, West, Nicholas P., Walker, Mark J., Paterson, David L., Beatson, Scott A. and Schembri, Mark A. (2017). Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Journal of Antimicrobial Chemotherapy, 72 (10), 2729-2736. doi: 10.1093/jac/dkx204
Ng, Benjamin Y. C., Wee, Eugene J. H., Woods, Kyra, Anderson, Will, Antaw, Fiach, Tsang, Hennes Z. H., West, Nicholas P. and Trau, Matt (2017). Isothermal point mutation detection: toward a first-pass screening strategy for multidrug-resistant tuberculosis. Analytical Chemistry, 89 (17), 9017-9022. doi: 10.1021/acs.analchem.7b01685
Turner, Andrew G., Ong, Cheryl-lynn Y., Djoko, Karrera Y., West, Nicholas P., Davies, Mark R., McEwan, Alastair G. and Walker, Mark J. (2017). The PerR-regulated P1B-4 type ATPase (PmtA) acts as a ferrous iron efflux pump in Streptococcus pyogenes. Infection and Immunity, 85 (6) e00140-17, e00140-17.1-e00140-17.13. doi: 10.1128/IAI.00140-17
Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata , Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Timothy D. H., Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J. and Payne, Richard J. (2017). Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis. Nature Communications, 8 (1) 14414, 14414. doi: 10.1038/ncomms14414
Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16
Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 (13), 4319-4323. doi: 10.1002/ange.201511985
Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016). Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 (13), 4247-4251. doi: 10.1002/anie.201511985
Ng, Benjamin Y. C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Naked-eye colorimetric and electrochemical detection of Mycobacterium tuberculosis—toward rapid screening for active case finding. ACS Sensors, 1 (2), 173-178. doi: 10.1021/acssensors.5b00171
Ng, Benjamin Y. C., Xiao, Wei, West, Nicholas P., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2015). Rapid, Single-Cell Electrochemical Detection of Mycobacterium tuberculosis Using Colloidal Gold Nanoparticles. Analytical Chemistry, 87 (20), 10613-10618. doi: 10.1021/acs.analchem.5b03121
Ng, Benjamin Y.C., Wee, Eugene J. H., West, Nicholas P. and Trau, Matt (2015). Rapid DNA detection of Mycobacterium tuberculosis-towards single cell sensitivity in point-of-care diagnosis. Scientific Reports, 5 (1) 15027, 15027.1-15027.7. doi: 10.1038/srep15027
Host-pathogen interaction during bacterial vaccination
Barnett, Timothy C., Lim, Jin Yan, Soderholm, Amelia T., Rivera-Hernandez, Tania, West, Nicholas P. and Walker, Mark J. (2015). Host-pathogen interaction during bacterial vaccination. Current Opinion in Immunology, 36, 1-7. doi: 10.1016/j.coi.2015.04.002
Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015). First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 (11), 4822-4838. doi: 10.1021/acs.jmedchem.5b00611
Turner, Andrew G., Ong, Cheryl-lynn, Gillen, Christine M., Davies, Mark R., West, Nicholas P., McEwan, Alastair G. and Walker, Mark J. (2015). Manganese homeostasis in group A Streptococcus is critical for resistance to oxidative stress and virulence. mBio, 6 (2) e00278-15, 1-10. doi: 10.1128/mBio.00278-15
The contribution of non-human primate models to the development of human vaccines
Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.
ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics
Marteyn, Benoit S., Karimova, Gouzel, Fenton, Andrew K., Gazi, Anastasia D., West, Nicholas, Touqui, Lhousseine, Prevost, Marie-Christine, Betton, Jean-Michel, Poyraz, Oemer, Ladant, Daniel, Gerdes, Kenn, Sansonetti, Philippe J. and Tang, Christoph M. (2014). ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics. mBio, 5 (2) e00022-14. doi: 10.1128/mBio.00022-14
Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing
Ly, Diane, Taylor, Jude M., Tsatsaronis, James A., Monteleone, Mercedes M., Skora, Amanda S., Donald, Cortny A., Maddocks, Tracy, Nizet, Victor, West, Nicholas P., Ranson, Marie, Walker, Mark J., McArthur, Jason D. and Sanderson-Smith, Martina L. (2014). Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. Journal of Innate Immunity, 6 (2), 240-250. doi: 10.1159/000353754
Tran, A. T., Wen, D., West, N. P., Baker, E. N., Britton, W. J. and Payne, R. J. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1- phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11 (46), 8113-8126. doi: 10.1039/c3ob41896k
Tyne, Anneliese S., Chan, John Gar Yan, Shanahan, Erin R., Atmosukarto, Ines, Chan, Hak-Kim, Britton, Warwick J. and West, Nicholas P. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31 (40), 4322-4329. doi: 10.1016/j.vaccine.2013.07.022
Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013). Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 (17), 6967-6984. doi: 10.1021/jm400779n
Pinto, Rachel, Leotta, Lisa, Shanahan, Erin R., West, Nicholas P., Leyh, Thomas S., Britton, Warwick and Triccas, James A. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. Journal of Infectious Diseases, 207 (5), 778-785. doi: 10.1093/infdis/jis751
Anh Thu Tran, West, Nicholas P., Britton, Warwick J. and Payne, Richard J. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. Chemmedchem, 7 (6), 1031-1043. doi: 10.1002/cmdc.201100606
Kao, Fan F., Mahmuda, Sultana, Pinto, Rachel, Triccas, James A., West, Nicholas P. and Britton, Warwick J. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7 (5) e34991, e34991. doi: 10.1371/journal.pone.0034991
Manos-Turvey, Alexandra, Cergol, Katie M., Salam, Noeris K., Bulloch, Esther M. M., Chi, Gamma, Pang, Angel, Britton, Warwick J., West, Nicholas P., Baker, Edward N., Lott, J. Shaun and Payne, Richard J. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10 (46), 9223-9236. doi: 10.1039/c2ob26736e
West, Nicholas P., Thomson, Scott A., Triccas, James A., Medveczky, C. Jill, Ramshaw, Ian A. and Britton, Warwick J. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29 (44), 7759-7765. doi: 10.1016/j.vaccine.2011.07.109
Anh Thu Tran, Cergol, Katie M., West, Nicholas P., Randall, Elizabeth J., Britton, Warwick J., Bokhari, Syed Ali Imran, Ibrahim, Musadiq, Lapthorn, Adrian J. and Payne, Richard J. (2011). Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads. Chemmedchem, 6 (2), 262-265. doi: 10.1002/cmdc.201000399
Immunity to mycobacterium tuberculosis
Triccas, James A., Winter, Nathalie, Feng, Carl G. and West, Nicholas P. (2011). Immunity to mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011 (406549) 406549, 1-2. doi: 10.1155/2011/406549
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads
West, Nicholas P., Cergol, Katie M., Xue, Millie, Randall, Elizabeth J., Britton, Warwick J. and Payne, Richard J. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47 (18), 5166-5168. doi: 10.1039/c0cc05635a
Crellin, Paul K., Vivian, Julian P., Scoble, Judith, Chow, Frances M., West, Nicholas P., Brammananth, Rajini, Proellocks, Nicholas I., Shahine, Adam, Le Nours, Jerome, Wilce, Matthew C. J., Britton, Warwick J., Coppel, Ross L., Rossjohn, Jamie and Beddoe, Travis (2010). Tetrahydrolipstatin Inhibition, Functional Analyses, and Three-dimensional Structure of a Lipase Essential for Mycobacterial Viability. Journal of Biological Chemistry, 285 (39), 30050-30060. doi: 10.1074/jbc.M110.150094
Modulation of Shigella virulence in response to available oxygen in vivo
Marteyn, Benoit, West, Nicholas P., Browning, Douglas F., Cole, Jeffery A., Shaw, Jonathan G., Palm, Fredrik, Mounier, Joelle, Prevost, Marie-Christine, Sansonetti, Philippe and Tang, Christoph M. (2010). Modulation of Shigella virulence in response to available oxygen in vivo. Nature, 465 (7296), 355-358+2. doi: 10.1038/nature08970
Shanahan, Erin R., Pinto, Rachel, Triccas, James A., Britton, Warwick J. and West, Nicholas P. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28 (5), 1341-1346. doi: 10.1016/j.vaccine.2009.11.010
West, Nicholas P., Chow, Frances M. E., Randall, Elizabeth J., Wu, Jing, Chen, Jian, Ribeiro, Jose M. C. and Britton, Warwick J. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. Faseb Journal, 23 (6), 1694-1704. doi: 10.1096/fj.08-114421
Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis
West, Nicholas P., Wozniak, Teresa M., Valenzuela, Jesus, Feng, Carl G., Sher, Alan, Ribeiro, Jose M. C. and Britton, Warwick J. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26 (31), 3853-3859. doi: 10.1016/j.vaccine.2008.05.007
Available carbon source influences the resistance of Neisseria meningitidis against complement
Exley, RM, Shaw, J, Mowe, E, Sun, YH, West, NP, Williamson, M, Botto, M, Smith, H and Tang, CM (2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. Journal of Experimental Medicine, 201 (10), 1637-1645. doi: 10.1084/jem.20041548
Optimization of virulence functions through glucosylation of Shigella LPS
West, NP, Sansonetti, P, Mounier, J, Exley, RM, Parsot, C, Guadagnini, S, Prevost, MC, Prochnicka-Chalufour, A, Delepierre, M, Tanguy, M and Tang, CM (2005). Optimization of virulence functions through glucosylation of Shigella LPS. Science, 307 (5713), 1313-1317. doi: 10.1126/science.1108472
Finding your niche: what has been learnt from STM studies on GI colonization
West, NP, Sansonetti, PJ, Frankel, G and Tang, CM (2003). Finding your niche: what has been learnt from STM studies on GI colonization. Trends in Microbiology, 11 (7), 338-344. doi: 10.1016/S0966-842X(03)00154-9
McArthur, JD, West, NP, Cole, JN, Jungnitz, H, Guzman, CA, Chin, J, Lehrbach, PR, Djordjevic, SP and Walker, MJ (2003). An aromatic amino acid auxotrophic mutant of Bordetella bronchiseptica is attenuated and immunogenic in a mouse model of infection. Fems Microbiology Letters, 221 (1), 7-16. doi: 10.1016/S0378-1097(03)00162-9
High throughput in vivo screens: Signature-tagged mutagenesis
West, N, Sansonetti, P and Tang, CM (2002). High throughput in vivo screens: Signature-tagged mutagenesis. Functional Microbial Genomics, 33, 153-165.
West, Nicholas P., Jungnitz, Heidrun, Fitter, John T., McArthur, Jason D., Guzman, Carlos A. and Walker, Mark J. (2000). Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence. Infection and Immunity, 68 (8), 4673-4680. doi: 10.1128/IAI.68.8.4673-4680.2000
Jungnitz, Heidrun, West, Nicholas P., Walker, Mark J., Chhatwal, Gursharan S. and Guzman, Carlos A. (1998). A second two-component regulatory system of Bordetella bronchiseptica required for bacterial resistance to oxidative stress, production of acid phosphatase, and in vivo persistence. Infection and Immunity, 66 (10), 4640-4650.
West, NP, Fitter, JT, Jakubzik, U, Rodhe, M, Guzman, CA and Walker, MJ (1997). Non-motile mini-transposon mutants of Bordetella bronchiseptica exhibit altered abilities to invade and survive in eukaryotic cells. Fems Microbiology Letters, 146 (2), 263-269. doi: 10.1111/j.1574-6968.1997.tb10203.x
Lee, Brendon, Almeida, Deepak, Afriat-Jurnou, Livnat, Aung, Htin, Forde, Brian, Harold, Liam, Hards, Kiel, Pidot, Sacha, Ahmed, Hafna, Mohamed, Elaaf, Taylor, Mathew, West, Nicholas, Stinear, Timothy, Greening, Chris, Beatson, Scott, Cook, Gregory, Nuermberger, Eric and Jackson, Colin (2020). Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering. Annual Meeting on Experimental Biology, San Diego, CA, United States, 4-7 April 2020. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1096/fasebj.2020.34.s1.04923
A Faster Cure for Tuberculosis: Revealing Adjunctive Antimicrobial Solutions
(2023–2027) NHMRC IDEAS Grants
Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
(2021–2024) ARC Discovery Projects
Blocking TB Latency: The Key to Reducing Therapy Duration
(2019–2023) NHMRC Project Grant
Ketol-acid reductoisomerase: An important antituberculosis drug target
(2018–2021) NHMRC Project Grant
(2018–2021) Walter & Eliza Hall Institute of Medical Research (WEHI)
(2018–2020) University of Sydney
(2018–2020) Australian National University
(2018) UQ Major Equipment and Infrastructure
Instrumentation for the analysis of cellular and metabolic phenotypes
(2016) UQ Major Equipment and Infrastructure
(2015–2017) University of Sydney
(2015–2017) University of Sydney
(2015–2017)
(2015) UQ Major Equipment and Infrastructure
Latent Vaccine Development as Directed by in vivo Modeling
(2014–2016) Centenary Institute
(2014) UQ Major Equipment and Infrastructure
Genes of Mycobacterium tuberculosis essential for Latent Tuberculosis Infection
(2013–2016) NHMRC Project Grant
(2013–2015) University of Sydney
Potent antibiotics against drug-resistant Tuberculosis
(2013–2015) NHMRC Development Grant
Facility of Tuberculosis Research
(2013) NHMRC Equipment Grant
Design, development and analysis of new tuberculosis drugs
(2012–2014) NHMRC Project Grant
(2012–2014) NHMRC Career Development Award
(2012–2013) UQ New Staff Research Start-Up Fund
A Multidisciplinary Approach to Identifying Novel Vaccine and Drug Targets of Non-Tuberculous Mycobacteria
Doctor Philosophy — Principal Advisor
Other advisors:
Boosting BCG: The use of Potent Immunostimulatory Secreted Antigens of Mycobacterium tuberculosis.
Doctor Philosophy — Principal Advisor
Insertional mutagenesis of Cryptococcus neoformans
Doctor Philosophy — Associate Advisor
Other advisors:
(2023) Doctor Philosophy — Principal Advisor
Disseminated Tuberculosis; Defining Pathogen Encoded Mechanisms
(2022) Doctor Philosophy — Principal Advisor
Other advisors:
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
New Antimicrobial Drug Targets
(2023) Doctor Philosophy — Associate Advisor
Other advisors:
Point-of-care tuberculosis diagnostics: Meeting global needs through innovative nanotechnologies
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
(2016) Doctor Philosophy — Associate Advisor
Other advisors: