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Electrophysiology Platform for Ion-channel Characterisation (2020)

Abstract:
Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.
Grant type:
ARC Linkage Infrastructure, Equipment and Facilities
Researchers:

  • Professor Glenn King

    Professorial Research Fellow - Grou
    Institute for Molecular Bioscience
    Professorial Research Fellow - Grou
    Institute for Molecular Bioscience
    Affiliate Professor of School of Ch
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience

  • Professor Irina Vetter

    NHMRC Leadership Fellow - Group Lea
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow - Group Lea
    School of Pharmacy
    Faculty of Health and Behavioural Sciences
    NHMRC Leadership Fellow - Group Lea
    Institute for Molecular Bioscience

  • Professor Richard Lewis

    Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Affiliate Professor of School of Bi
    School of Biomedical Sciences
    Faculty of Medicine

  • Dr Lachlan Rash

    Associate Professor
    School of Biomedical Sciences
    Faculty of Medicine
    Associate Professor
    School of Biomedical Sciences
    Faculty of Medicine

  • Associate Professor Nathan Palpant

    National Heart Foundation of Austra
    Institute for Molecular Bioscience
    National Heart Foundation of Austra
    Institute for Molecular Bioscience
    Affiliate Senior Research Fellow of
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
Australian Research Council