The University of Queensland

Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature

Hsu, Chia Lee and Layton, Christopher J. (2015). Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature. Case Reports in Ophthalmology, 6 (2), 251-259. doi: 10.1159/000437381

Factors associated with significant ocular injury in conservatively treated orbital fractures

Layton, Christopher J. (2014). Factors associated with significant ocular injury in conservatively treated orbital fractures. Journal of Ophthalmology, 2014 412397, 412397.1-412397.6. doi: 10.1155/2014/412397

Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat

Layton, Christopher J., Chidlow, Glyn, Casson, Robert J., Wood, John P. M., Graham, Mark and Osborne, Neville N. (2004). Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat. Investigative Ophthalmology and Visual Science, 46 (8), 2878-2885. doi: 10.1167/iovs.04-1458

AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?

Castro, Brenda, Steel, Jason C. and Layton, Christopher J. (2024). AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?. Expert Reviews in Molecular Medicine, 26 e9. doi: 10.1017/erm.2024.4

AAV-Based Strategies for Treatment of Retinal and Choroidal Vascular Diseases: Advances in Age-Related Macular Degeneration and Diabetic Retinopathy Therapies

Castro, Brenda F. M., Steel, Jason C. and Layton, Christopher J. (2023). AAV-Based Strategies for Treatment of Retinal and Choroidal Vascular Diseases: Advances in Age-Related Macular Degeneration and Diabetic Retinopathy Therapies. BioDrugs, 38 (1), 73-93. doi: 10.1007/s40259-023-00629-y

Attitudes of eye health practitioners towards diagnostic tests and therapies for dry eye disease in Australasia

Li, Ye, Smith, Robert G., Steel, Jason C. and Layton, Christopher J. (2022). Attitudes of eye health practitioners towards diagnostic tests and therapies for dry eye disease in Australasia. Contact Lens and Anterior Eye, 45 (6) 101724, 1-6. doi: 10.1016/j.clae.2022.101724

Differences in uveal melanoma age-standardized incidence rates in two eastern states of Australia are driven by differences in rurality and ultraviolet radiation

Chalada, Melissa, Ramlogan-steel, Charmaine A., Dhungel, Bijay P., Goh, Amanda Y., Gardiner, Samuel, Layton, Christopher J. and Steel, Jason C. (2021). Differences in uveal melanoma age-standardized incidence rates in two eastern states of Australia are driven by differences in rurality and ultraviolet radiation. Cancers, 13 (23) 5894. doi: 10.3390/cancers13235894

Neutralisation of adeno-associated virus transduction by human vitreous humour

Andrzejewski, Sławomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason C. and Layton, Christopher J. (2021). Neutralisation of adeno-associated virus transduction by human vitreous humour. Gene Therapy, 28 (5), 242-255. doi: 10.1038/s41434-020-0162-8

The impact of ultraviolet radiation on the aetiology and development of uveal melanoma

Chalada, Melissa, Ramlogan-Steel, Charmaine A., Dhungel, Bijay P., Layton, Christopher J. and Steel, Jason C. (2021). The impact of ultraviolet radiation on the aetiology and development of uveal melanoma. Cancers, 13 (7) 1700, 1700. doi: 10.3390/cancers13071700

Time‐to‐event survival statistics in ophthalmology: methodological research

Layton, Christopher J. and Layton, Danielle M. (2020). Time‐to‐event survival statistics in ophthalmology: methodological research. Clinical and Experimental Ophthalmology, 48 (9) ceo.13848, 1136-1145. doi: 10.1111/ceo.13848

Characterisation and validation of the 8-fold quadrant dissected human retinal explant culture model for pre-clinical toxicology investigation

Murali, Aparna, Ramlogan-Steel, Charmaine A., Steel, Jason C. and Layton, Christopher J. (2020). Characterisation and validation of the 8-fold quadrant dissected human retinal explant culture model for pre-clinical toxicology investigation. Toxicology in Vitro, 63 104716, 1-10. doi: 10.1016/j.tiv.2019.104716

Presence and prevalence of uv related genetic mutations in uveal melanoma: similarities with cutaneous melanoma

Goh, A. Y., Ramlogan-Steel, C. A., Jenkins, K. S., Steel, J. C. and Layton, C. J. (2020). Presence and prevalence of uv related genetic mutations in uveal melanoma: similarities with cutaneous melanoma. Neoplasma, 67 (5), 958-971. doi: 10.4149/neo_2020_190815N768

Gene therapy and the adeno associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: trials, future directions and safety considerations

Ramlogan-Steel, Charmaine A., Murali, Aparna, Andrzejewski, Slawomir, Dhungel, Bijay, Steel, Jason C. and Layton, Christopher J. (2019). Gene therapy and the adeno associated virus in the treatment of genetic and acquired ophthalmic diseases in humans: trials, future directions and safety considerations. Clinical & Experimental Ophthalmology, 47 (4), 521-536. doi: 10.1111/ceo.13416

Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus

Andrzejewski, Slawomir, Murali, Aparna, Ramlogan-Steel, Charmaine, Edwards, Katie P., Efron, Nathan, Steel, Jason C. and Layton, Christopher J. (2019). Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus. Gene Therapy, 26 (6), 250-263. doi: 10.1038/s41434-019-0076-5

Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy

Jenkins, K. Sean, Steel, Jason C. and Layton, Christopher J. (2018). Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy. Journal of Ophthalmology, 2018 8479850, 1-9. doi: 10.1155/2018/8479850

microRNA199a based post-transcriptional detargeting of gene vectors for Hepatocellular Carcinoma

Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). microRNA199a based post-transcriptional detargeting of gene vectors for Hepatocellular Carcinoma. Molecular Therapy - Nucleic Acids, 13, 78-88. doi: 10.1016/j.omtn.2018.08.016

Retinal explant culture: a platform to investigate human neuro-retina

Murali, Aparna, Ramlogan-Steel, Charmaine A., Andrzejewski, Slawomir, Steel, Jason C. and Layton, Christopher J. (2018). Retinal explant culture: a platform to investigate human neuro-retina. Clinical & Experimental Ophthalmology, 47 (2) ceo.13434, 274-285. doi: 10.1111/ceo.13434

Current evidence for the prevention of endophthalmitis in anti-VEGF intravitreal injections

Lau, P. ET., Jenkins, K. S. and Layton, C. J. (2018). Current evidence for the prevention of endophthalmitis in anti-VEGF intravitreal injections. Journal of Ophthalmology, 2018 8567912, 1-8. doi: 10.1155/2018/8567912

miRNA122a regulation of gene therapy vectors targeting hepatocellular cancer stem cells

Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). miRNA122a regulation of gene therapy vectors targeting hepatocellular cancer stem cells. OncoTarget, 9 (34), 23577-23588. doi: 10.18632/oncotarget.25280

Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma

Dhungel, Bijay, Andrzejewski, Slawomir, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine A., Layton, Christopher J. and Steel, Jason C. (2018). Evaluation of the glypican-3 promoter for transcriptional targeting of hepatocellular carcinoma. Molecular Therapy, 25 (2), 115-128. doi: 10.1038/s41434-018-0002-2

A novel ABCA4 mutation associated with a late-onset Stargardt disease phenotype: a hypomorphic allele?

Kaway, Cindy S., Adams, Madeleine K. M., Jenkins, Kevin Sean and Layton, Christopher J. (2017). A novel ABCA4 mutation associated with a late-onset Stargardt disease phenotype: a hypomorphic allele?. Case Reports in Ophthalmology, 8 (1), 180-184. doi: 10.1159/000464129

Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma

Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J. and Steel, Jason C. (2017). Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma. Drug Delivery, 24 (1), 289-299. doi: 10.1080/10717544.2016.1247926

External ophthalmomyiasis caused by oestrus ovis

Jenkins, K. Sean and Layton, Christopher J. (2017). External ophthalmomyiasis caused by oestrus ovis. Clinical and Experimental Ophthalmology, 46 (3), 300-301. doi: 10.1111/ceo.13033

Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy

de Moraes, Gabriela and Layton, Christopher J. (2016). Therapeutic targeting of diabetic retinal neuropathy as a strategy in preventing diabetic retinopathy. Clinical and Experimental Ophthalmology, 44 (9), 838-852. doi: 10.1111/ceo.12795

An eye for art? A challenge of ophthalmic body modification

Jenkins, Kevin Sean and Layton, Christopher J. (2016). An eye for art? A challenge of ophthalmic body modification. Clinical and Experimental Ophthalmology, 44 (8), 741-741. doi: 10.1111/ceo.12758

Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design

Lim, Paul C. C. and Layton, Christopher J. (2016). Prognostic implications of imaging in atrophic macular degeneration and its use in clinical practice and clinical trial design. Clinical and Experimental Ophthalmology, 44 (5), 410-421. doi: 10.1111/ceo.12671

Evolving systemic targeted therapy strategies in uveal melanoma and implications for ophthalmic management: a review

Goh, Amanda Y. L. and Layton, Christopher J. (2016). Evolving systemic targeted therapy strategies in uveal melanoma and implications for ophthalmic management: a review. Clinical and Experimental Ophthalmology, 44 (6), 509-519. doi: 10.1111/ceo.12688

Diabetic levels of glucose increase cellular reducing equivalents but reduce survival in three models of 661W photoreceptor-like cell injury

Layton, Christopher J. (2015). Diabetic levels of glucose increase cellular reducing equivalents but reduce survival in three models of 661W photoreceptor-like cell injury. BMC Ophthalmology, 15 (174) 174, 174. doi: 10.1186/s12886-015-0164-2

Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature

Hsu, Chia Lee and Layton, Christopher J. (2015). Familial disorders of the optic disc: presentation of a mother and daughter and review of the literature. Case Reports in Ophthalmology, 6 (2), 251-259. doi: 10.1159/000437381

Factors associated with significant ocular injury in conservatively treated orbital fractures

Layton, Christopher J. (2014). Factors associated with significant ocular injury in conservatively treated orbital fractures. Journal of Ophthalmology, 2014 412397, 412397.1-412397.6. doi: 10.1155/2014/412397

Oscillatory potentials and the b-Wave: partial masking and interdependence in dark adaptation and diabetes in the rat

Layton, C. J., Safa, R. and Osborne, N. N. (2007). Oscillatory potentials and the b-Wave: partial masking and interdependence in dark adaptation and diabetes in the rat. Graefe's Archive for Clinical and Experimental Ophthalmology, 245 (9), 1335-1345. doi: 10.1007/s00417-006-0506-0

The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2

Layton, C. J., Becker, S. and Osborne, N. N. (2006). The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2. Molecular Vision, 12, 46-54.

The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2

Layton, CJ, Becker, S and Osborne, NN (2006). The effect of insulin and glucose levels on retinal glial cell activation and pigment epithelium-derived fibroblast growth factor-2. Molecular Vision, 12 (5), 43-54.

Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner

Layton, C. J., Chidlow, G., Wood, J. P. M. and Osborne, N. N. (2005). Neuronal death in primary retinal cultures is related to nitric oxide production, and is inhibited by erythropoietin in a glucose-sensitive manner. Journal of Neurochemistry, 92 (3), 487-493. doi: 10.1111/j.1471-4159.2004.02876.x

Survey of eye practitioners' attitudes towards diagnostic tests and therapies for dry eye disease

Turner, Angus W., Layton, Christopher J. and Bron, Anthony J. (2005). Survey of eye practitioners' attitudes towards diagnostic tests and therapies for dry eye disease. Clinical and Experimental Ophthalmology, 33 (4), 351-355. doi: 10.1111/j.1442-9071.2005.01026.x

Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat

Layton, Christopher J., Chidlow, Glyn, Casson, Robert J., Wood, John P. M., Graham, Mark and Osborne, Neville N. (2004). Monocarboxylate transporter expression remains unchanged during the development of diabetic retinal neuropathy in the rat. Investigative Ophthalmology and Visual Science, 46 (8), 2878-2885. doi: 10.1167/iovs.04-1458

Optic nerve and neuroprotection strategies

Osborne, N. N., Chidlow, G., Layton, C. J., Wood, J. P. M., Casson, R. J. and Melena, J. (2004). Optic nerve and neuroprotection strategies. Eye, 18 (11), 1075-1084. doi: 10.1038/sj.eye.6701588

Clinical aspects of conjunctival melanoma

Layton, Christopher Layton and Glasson, William (2002). Clinical aspects of conjunctival melanoma. Clinical and Experimental Ophthalmology, 30 (2), 72-79. doi: 10.1046/j.1442-6404.2002.00490.x

Recombinant Adeno-Associated Virus Vector Tropism in Human Retina

Andrzejewski, Slawomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason and Layton, Christopher J. (2020). Recombinant Adeno-Associated Virus Vector Tropism in Human Retina. In: 23rd Annual Meeting of the American Society for Gene and Cell Therapy, Electr Network, (254-254). 12-15 May 2020.

Effect of human vitreous humour components and neutralising antibodies on transduction activity of recombinant AAV2, AAV5, AAV6 and AAV8

Andrzejewski, S., Moyle, P., Stringer, B., Steel, J. and Layton, C. J. (2019). Effect of human vitreous humour components and neutralising antibodies on transduction activity of recombinant AAV2, AAV5, AAV6 and AAV8. Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Sheffield, United Kingdom , 19-21 June 2019. New Rochelle, NY, United States: Mary Ann Liebert.

Evaluation of tumor specific promoters for transcriptional targeting of hepatocellular carcinoma

Dhungel, Bijay, Jayachandran, Aparna, Layton, Christopher J. and Steel, Jason C. (2018). Evaluation of tumor specific promoters for transcriptional targeting of hepatocellular carcinoma. Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), Sydney Australia, May 24-26, 2017. Hoboken, NJ United States: Wiley.

Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma

Goh, A., Ramlogan-Steel, C., Jayachandran, A., Steel, J. and Layton, C. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27 - 30 September 2017. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.02787

Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma

Goh, A., Ramlogan-Steel, C., Jayachandran, A., Steel, J. and Layton, C. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.02787

The 8-fold quadrant dissection method for ex vivo human interventional retinal experimentation

Murali, A., Ramlogan-Steel, C., Andrzejewski, S., Dhungel, B., Steel, J. and Layton, C. (2017). The 8-fold quadrant dissection method for ex vivo human interventional retinal experimentation. 2017 European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/j.1755-3768.2017.01558

Evaluation of the Glypican-3 Promoter for Transcriptional Targeting of Hepatocellular Carcinoma

Dhungel, Bijay, Jayachandran, Aparna, Shrestha, Ritu, Ramlogan-Steel, Charmaine, Layton, Christopher J. and Steel, Jason C. (2017). Evaluation of the Glypican-3 Promoter for Transcriptional Targeting of Hepatocellular Carcinoma. 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington DC United States, 10-13 May 2017. CAMBRIDGE: Cell Press.

Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium

Layton, C. J., Dhungel, B. , Andrzejewski, S. , Jayachandran, A. , Murali, A. and Steel, J. S. (2017). Gene therapy targeting of choroidal disease and AAV transcytosis through the outer blood retina barrier epithelium. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.02683

Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma

Goh, A. , Ramlogan‐Steel, C. , Jayachandran, A., Steel, J. and Layton, C. J. (2017). Genetic evidence for the role of ultraviolet radiation in the pathogenesis of uveal melanoma. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.02787

Ophthalmoscopic and video OCT methods to detect spontaneous venous pulsation in individuals with apparently normal intracranial pressure: the rebirth of the SVP?

Jenkins, K. S., Adams, M. K. M. and Layton, C. J. (2017). Ophthalmoscopic and video OCT methods to detect spontaneous venous pulsation in individuals with apparently normal intracranial pressure: the rebirth of the SVP?. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2017.01516

The 8‐fold quadrant dissection method for ex vivo human interventional retinal experimentation

Murali, A., Ramlogan‐Steel, C., Andrzejewski, S., Dhungel, B., Steel, J. and Layton, C. J. (2017). The 8‐fold quadrant dissection method for ex vivo human interventional retinal experimentation. European Association for Vision and Eye Research Conference, Nice, France, 27-30 September 2017. Hoboken, NJ United States: Wiley-Blackwell . doi: 10.1111/j.1755-3768.2017.01558

Effects of erythropoietin on glucose induced exacerbation of hypoxic damage in cultured photoreceptor-like cells

Layton, Christopher J., Kawai, Cindy S., de Moraes, Gabriela, Jenkins, Kevin and Goh, Amanda Y. (2016). Effects of erythropoietin on glucose induced exacerbation of hypoxic damage in cultured photoreceptor-like cells. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Seattle, WA United States, 1-5 May 2016. Rockville, MD United States: Association for Research in Vision and Ophthalmology.

Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy

Jenkins, K. S., Rowan, A. and Layton, C. J. (2016). Systematic assessment of clinical methods to diagnose and monitor diabetic retinal neuropathy. 2016 European Association for Vision and Eye Research Conference, Nice, France, 5-8 October 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2016.0565

The effect of glucose and insulin on the susceptibility of cultured photoreceptor-like cells to hypoxia

Layton, C. J. and de Moraes, G. (2015). The effect of glucose and insulin on the susceptibility of cultured photoreceptor-like cells to hypoxia. European Association for Vision and Eye Research Conference, Nice, France, 7-10 Oct. 2015. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1755-3768.2015.0711

Erythropoietin assists neuronal survival and reduces nitric oxide production in retinal cultures at low but not moderate glucose concentrations.

Layton, CJ, Wood, JPM, Turner, A and Osborne, NN (2004). Erythropoietin assists neuronal survival and reduces nitric oxide production in retinal cultures at low but not moderate glucose concentrations.. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale Fl, Apr 24-29, 2004. ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.

Localisation of monocarboxylate transporter subtypes 1-4 in the rat eye

Osborne, NN, Layton, CJ, Wood, JPM, Graham, M and Chidlow, G (2003). Localisation of monocarboxylate transporter subtypes 1-4 in the rat eye. Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Ft Lauderdale Florida, May 04, 2003. ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.

Expression vector and method

Layton, Christopher and Steel, Jason (2021). Expression vector and method. US Patent App. 16/963,880.