Conjoint Professor Paul Robinson is the Deputy Director of the Children’s Health Environment Program within the Child Health Research Centre (CHRC), and Senior Staff Specialist in Respiratory and Sleep Medicine at the Queensland Children’s Hospital. His research program performs translational research outlining the role of peripheral airway function tests in early lung disease detection and ongoing monitoring of established disease.
He has led the development and standardisation of novel measures of lung function across the entire age range from infancy onwards, facilitating the development of commercial equipment available for widespread use. His research focuses on defining the clinical utility of two specific peripheral airway function tests (Multiple breath washout, MBW, and oscillometry) in important obstructive lung diseases (e.g., asthma, cystic fibrosis, and post bone marrow transplant pulmonary graft vs host disease) and in understanding the impacts of environmental exposures. Structure-function relationships have been explored using state-of-the-art imaging techniques, with the aim of also developing new strategies to reduce any radiation exposure associated with these to advance incorporation into clinical care (e.g., ultra-low dose CT).
These novel lung function tools not only in the hospital setting but also in the school and home setting, enabling the successful development of a parent-supervised remote monitoring strategy for asthma which has been shown to reflect clinically meaningful outcomes missed by conventional approaches. In collaboration with industry, this strategy is now being employed in a series of research projects.
Involvement in longitudinal birth cohorts has outlined the early lung function trajectories in health, and the identification of risk factors affecting normal lung development and contributing to the early development of asthma. Studies investigating environmental health have highlighted the adverse effects of ultrafine particle air pollution.
Professor Robinson’s standing as an international expert, both in terms of clinical and research experience, has led to broader leadership roles across national and international levels.
Professor Robinson’s research program has informed a paradigm shift in management of chronic respiratory disease to ignore the reassurance of “normal” conventional lung function (spirometry) and target early lung disease detection arising in the peripheral airways and intervention through proactive (not reactive symptom-driven) strategies for 3 important obstructive lung conditions: (1) cystic fibrosis (CF); (2) asthma; and (3) post haemopoietic stem cell transplant (HSCT) pulmonary graft-vs-host disease (pGVHD).
Impact is evidenced by >150 published manuscripts of which >80 manuscripts are specific to this research program focus. A lead role on seminal consensus standards have resulted in a >4-times increase in MBW publications since their publication and widespread availability of robust commercial equipment (based on consensus recommendations adopted by all 4 global manufacturers). MBW has been formally as a primary outcome measure for CF intervention studies by independent institutions and integration into >30 international multicentre clinical trials. MBW has played a central role in registration of effective CFTR modulator therapy for young children, with significant projected survival benefits. Advances in oscillometry, including novel remote monitoring approaches targeting enhanced detection of disease exacerbation and prevention, have provided a platform for the first consensus clinical applications document for oscillometry.
Journal Article: In utero smoking exposure induces changes to lung clearance index and modifies risk of wheeze in infants
De Queiroz Andrade, Ediane, Sena, Carla Rebeca Da Silva, de Gouveia Belinelo, Patricia, Robinson, Paul D., Blaxland, Anneliese, Sly, Peter D., Murphy, Vanessa E., Gibson, Peter G., Collison, Adam M. and Mattes, Joerg (2024). In utero smoking exposure induces changes to lung clearance index and modifies risk of wheeze in infants. Pediatric Pulmonology. doi: 10.1002/ppul.26975
Journal Article: Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity
Sena, Carla Rebeca Da Silva, Morten, Matthew, Collison, Adam M., Shaar, Aida, Andrade, Ediane de Queiroz, Meredith, Joseph, Kepreotes, Elizabeth, Murphy, Vanessa E., Sly, Peter D., Whitehead, Bruce, Karmaus, Wilfried, Gibson, Peter G., Robinson, Paul D. and Mattes, Joerg (2023). Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity. Pediatric Pulmonology, 59 (3), 632-641. doi: 10.1002/ppul.26793
Journal Article: Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis
SINGH, Jagdev, ROBINSON, Paul, PANDIT, Chetan, KENNEDY, Brendan, WELDON, Beth, BAILEY, Brooke, JOHN, Merilyn, FITZGERALD, Dominic and SELVADURAI, Hiran (2023). Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis. Minerva Pediatrics. doi: 10.23736/s2724-5276.23.07221-x
(2023–2028) Vertex Pharmaceuticals Inc
(2023–2027) University of Melbourne
MBW Training and LCI Overread Services in Support of VX20-455-112
(2023–2026) Vertex Pharmaceuticals Inc
Remote monitoring of Paediatric Asthma to Improve Asthma Diagnosis and Control
Childhood asthma mortality remains substantial, and rates of hospitalisation are increasing globally in young children. This is driven by poor asthma control (which affects 50% of asthmatics) and ongoing exacerbations (which affects 25%). Of the 40,000 admissions each year, 80% are preventable! Current symptom-based management approaches fail – limited by poor perception/reporting by children and parents - and conventional spirometry/peak flow is insensitive or too challenging for this setting. In addition, the preschool age range is a critical period in asthma pathogenesis: symptoms emerge, airway structure changes, and a window for intervention exists before permanent lung function deficit is established by early school age. Preschool symptom-based diagnostic and/or predictive tools (for later asthma) perform poorly and ignore lung function due to spirometry’s limitations. Improved ability to differentiate early asthma phenotypes is a priority of international societies.
This research program consists of a series of projects to analyse existing, and collect new, data to define the clinical utility of a unique remote home-based monitoring strategy focused on the day-to-day variability of a novel and sensitive lung function test. Studies will investigate its ability to correctly identify evolving asthma, detect loss of asthma control and provide an early signal of an impending asthma exacerbation to improve long term asthma outcomes.
Improving detection of Pulmonary Graft-vs-Host Disease to facilitate earlier intervention
Chronic Graft-vs-Host Disease affects 60% of Haematopoeitic Stem Cell Transplant (HSCT) survivors by 6 years after their transplant, affecting multiple organs including skin, liver, gastrointestinal tract and lungs. Gold standard for pulmonary GVHD diagnosis is abnormal spirometry and subsequent CT-based imaging. Pulmonary GVHD is estimated to affect 20% of all subjects post HSCT yet this incidence is a gross underestimate due to the insensitivity of spirometry to detect peripheral lung changes. This leads to late diagnosis, poor response to treatment, and poor prognosis (5-year mortality is 85%). Better tools to detect and monitor pulmonary GVHD are urgently required.
This research program builds on previous work highlighting the potential utility of novel peripheral airway function test in this setting. It will analyse both local data and pooled international data across 12 international centres (including both paediatric and adult data) to define the utility of these tools to provide an earlier diagnosis of pulmonary GVHD to facilitate earlier invention and improve outcomes. It will also explore novel applications of these tests to enhance detection further in the initial period post HSCT to predict and detect those at risk.
Lung Function Testing Including Multiple Breath Washout
Robinson, Paul D. (2023). Lung Function Testing Including Multiple Breath Washout. Hodson and Geddes' Cystic Fibrosis. (pp. 497-511) Boca Raton: CRC Press. doi: 10.1201/9781003262763-47
Muller, Sarah M., Ram, Sundaresh, Bayfield, Katie J., Reuter, Julia H., Gestewitz, Sonja, Yu, Lifeng, Wielpütz, Mark O., Kauczor, Hans-Ulrich, Heussel, Claus P., Robinson, Terry E., Bartholmai, Brian J., Hatt, Charles R., Robinson, Paul D., Galban, Craig J. and Weinheimer, Oliver (2023). Deep Learning-Based Air Trapping Quantification Using Paired Inspiratory-Expiratory Ultra-low Dose CT. Lecture Notes in Computer Science. (pp. 432-441) Cham: Springer Nature Switzerland. doi: 10.1007/978-3-031-43898-1_42
Hutchison, Alastair A., Leclerc, Francis, Nève, Véronique, Jane Pillow, J. and Robinson, Paul D. (2015). The respiratory system. Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice. (pp. 55-112) Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/978-3-642-01219-8_4
Bronchiolitis obliterans syndrome in children
Robinson, Paul D. and Aurora, Paul (2013). Bronchiolitis obliterans syndrome in children. Bronchiolitis Obliterans Syndrome in Lung Transplantation. (pp. 237-250) Humana Press Inc.. doi: 10.1007/978-1-4614-7636-8_13
De Queiroz Andrade, Ediane, Sena, Carla Rebeca Da Silva, de Gouveia Belinelo, Patricia, Robinson, Paul D., Blaxland, Anneliese, Sly, Peter D., Murphy, Vanessa E., Gibson, Peter G., Collison, Adam M. and Mattes, Joerg (2024). In utero smoking exposure induces changes to lung clearance index and modifies risk of wheeze in infants. Pediatric Pulmonology. doi: 10.1002/ppul.26975
Sena, Carla Rebeca Da Silva, Morten, Matthew, Collison, Adam M., Shaar, Aida, Andrade, Ediane de Queiroz, Meredith, Joseph, Kepreotes, Elizabeth, Murphy, Vanessa E., Sly, Peter D., Whitehead, Bruce, Karmaus, Wilfried, Gibson, Peter G., Robinson, Paul D. and Mattes, Joerg (2023). Bronchiolitis hospital admission in infancy is associated with later preschool ventilation inhomogeneity. Pediatric Pulmonology, 59 (3), 632-641. doi: 10.1002/ppul.26793
Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis
SINGH, Jagdev, ROBINSON, Paul, PANDIT, Chetan, KENNEDY, Brendan, WELDON, Beth, BAILEY, Brooke, JOHN, Merilyn, FITZGERALD, Dominic and SELVADURAI, Hiran (2023). Factors influencing treatment response of pulmonary exacerbation in children with cystic fibrosis. Minerva Pediatrics. doi: 10.23736/s2724-5276.23.07221-x
CFTR modulator therapy: transforming the landscape of clinical care in cystic fibrosis
Taylor-Cousar, Jennifer L., Robinson, Paul D., Shteinberg, Michal and Downey, Damian G. (2023). CFTR modulator therapy: transforming the landscape of clinical care in cystic fibrosis. The Lancet, 402 (10408), 1171-1184. doi: 10.1016/S0140-6736(23)01609-4
Asthma and landscape fire smoke: a Thoracic Society of Australia and New Zealand position statement
McDonald, Vanessa M., Archbold, Gregory, Beyene, Tesfalidet, Brew, Bronwyn K., Franklin, Peter, Gibson, Peter G., Harrington, John, Hansbro, Philip M., Johnston, Fay H., Robinson, Paul D., Sutherland, Michael, Yates, Deborah, Zosky, Graeme R. and Abramson, Michael J. (2023). Asthma and landscape fire smoke: a Thoracic Society of Australia and New Zealand position statement. Respirology, 28 (11), 1023-1035. doi: 10.1111/resp.14593
Nationwide lung function monitoring from infancy in newborn-screened children with cystic fibrosis
Sandvik, Rikke M., Schmidt, Marika N., Voldby, Christian M., Buchvald, Frederik F., Olesen, Hanne V., Olsen, Jørgen, Kragh, Maja V., Rubak, Sune L. M., Pressler, Tacjana, Robinson, Paul D., Gustafsson, Per M., Skov, Marianne and Nielsen, Kim G. (2023). Nationwide lung function monitoring from infancy in newborn-screened children with cystic fibrosis. ERJ Open Research, 9 (5) 00317-2023, 1-14. doi: 10.1183/23120541.00317-2023
Warner, Sherridan, Blaxland, Anneliese, Counoupas, Claudio, Verstraete, Janine, Zampoli, Marco, Marais, Ben J., Fitzgerald, Dominic A., Robinson, Paul D. and Triccas, James A. (2023). Clinical and experimental determination of protection afforded by BCG vaccination against infection with non-tuberculous mycobacteria: a role in cystic fibrosis?. Vaccines, 11 (8) 1313. doi: 10.3390/vaccines11081313
Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
Sonneveld, Nicole, Rayment, Jonathan H., Usemann, Jakob, Nielsen, Kim G. and Robinson, Paul D. (2023). Multiple breath washout and oscillometry after allogenic HSCT: a scoping review. European Respiratory Review, 32 (169) 220251, 220251. doi: 10.1183/16000617.0251-2022
Finch, L. M., Robinson, P. D. and Szentpali, K. (2023). Utilising Hem-o-lok® ligation system to safely and efficiently divide bilioenteric fistulae in laparoscopic cholecystectomy. Annals of the Royal College of Surgeons of England, 105 (6), 579-580. doi: 10.1308/rcsann.2022.0095
Implementation and Evaluation of Ultra Low-Dose CT in Early Cystic Fibrosis Lung Disease
Bayfield, Katie J, Weinheimer, Oliver, Boyton, Christie, Fitzpatrick, Rachel, Middleton, Anna, Kennedy, Brendan, Blaxland, Anneliese, Jayasuriya, Geshani, Caplain, Neil, Issa, Hana, Goetti, Robert, Wielpütz, Mark O, Yu, Lifeng, Galban, Craig J, Robinson, Terry E, Bartholmai, Brian, Fitzgerald, Dominic, Selvadurai, Hiran and Robinson, Paul D (2023). Implementation and Evaluation of Ultra Low-Dose CT in Early Cystic Fibrosis Lung Disease. European Respiratory Journal, 62 (1) 2300286, 2300286. doi: 10.1183/13993003.00286-2023
Approaches to the management of haemoptysis in young people with cystic fibrosis
Sheppard, Megan, Selvadurai, Hiran, Robinson, Paul D., Pandit, Chetan, Chennapragada, S. Murthy and Fitzgerald, Dominic A. (2023). Approaches to the management of haemoptysis in young people with cystic fibrosis. Paediatric Respiratory Reviews, 46, 17-22. doi: 10.1016/j.prrv.2022.10.002
Reducing treatment burden in the era of CFTR modulators
Robinson, Paul D., Douglas, Tonia A. and Wainwright, Claire E. (2023). Reducing treatment burden in the era of CFTR modulators. The Lancet Respiratory Medicine, 11 (9), E78-E78. doi: 10.1016/s2213-2600(23)00223-0
De Queiroz Andrade, Ediane, Bailey, Brooke, Davies, Jane C., Jensen, Renee, Ratjen, Felix, Saunders, Clare J., Short, Christopher and Robinson, Paul D. (2023). Reply to migration is not the perfect answer: Optimized methodology to assess LCI agreement between corrected legacy multiple breath nitrogen washout data and that directly collected on updated software. Pediatric Pulmonology, 58 (7), 1861-1863. doi: 10.1002/ppul.26430
Prisk, G. Kim, Rutting, Sandra, Bozier, Jack, Thamrin, Cindy, Robinson, Paul D. and Thompson, Bruce R. (2023). Assessing the calculation of conductive and acinar ventilatory heterogeneity indices Scond and Sacin from multiple-breath washout data. Journal of Applied Physiology, 134 (4), 879-886. doi: 10.1152/japplphysiol.00423.2022
Bates, Jason H. T., Milne, Stephen, Handley, Blake M., Rutting, Sandra, Chapman, David G., King, Gregory G., Farah, Claude S., Robinson, Paul D. and Thamrin, Cindy (2023). Model analysis of multiple breath nitrogen washout data: robustness to variations in breathing pattern. Journal of Clinical Monitoring and Computing, 37 (2), 409-420. doi: 10.1007/s10877-022-00915-0
UnloCKing the Role of Creatine Kinase in Childhood Asthma
Forno, Erick and Robinson, Paul D. (2023). UnloCKing the Role of Creatine Kinase in Childhood Asthma. American Journal of Respiratory and Critical Care Medicine, 207 (5), 499-500. doi: 10.1164/rccm.202208-1552ED
Patterns of change in the severity of airway obstruction with Robin sequence in early infancy
Dede, Belema D., Robinson, Paul D., Castro, Chenda and Waters, Karen A. (2023). Patterns of change in the severity of airway obstruction with Robin sequence in early infancy. Plastic and Reconstructive Surgery - Global Open, 11 (2), e4819. doi: 10.1097/GOX.0000000000004819
The dilemma of improving rational antibiotic use in pediatric community-acquired pneumonia
Nguyen, Phuong T. K., Robinson, Paul D., Fitzgerald, Dominic A. and Marais, Ben J. (2023). The dilemma of improving rational antibiotic use in pediatric community-acquired pneumonia. Frontiers in Pediatrics, 11 1095166. doi: 10.3389/fped.2023.1095166
Sandvik, Rikke Mulvad, Lindblad, Anders, Robinson, Paul D., Nielsen, Kim G. and Gustafsson, Per (2023). Turning lung clearance index on its head. Reference data for SF6 multiple-breath washout derived ventilation distribution efficiency. Journal of Applied Physiology , 134 (2), 316-327. doi: 10.1152/japplphysiol.00541.2022
Digital respiratory medicine for children and young people
Drummond, David, Gonsard, Apolline and Robinson, Paul D. (2023). Digital respiratory medicine for children and young people. ERS Monograph, 2023, 122-131. doi: 10.1183/2312508X.10001323
Dedrick, Rebekah M., Smith, Bailey E., Cristinziano, Madison, Freeman, Krista G., Jacobs-Sera, Deborah, Belessis, Yvonne, Brown, A. Whitney, Cohen, Keira A., Davidson, Rebecca M., van Duin, David, Gainey, Andrew, Garcia, Cristina Berastegui, George, C. R. Robert, Haidar, Ghady, Ip, Winnie, Iredell, Jonathan, Khatami, Ameneh, Little, Jessica S., Malmivaara, Kirsi, McMullan, Brendan J., Michalik, David E., Moscatelli, Andrea, Nick, Jerry A., Ortiz, Maria G. Tupayachi, Polenakovik, Hari M., Robinson, Paul D., Skurnik, Mikael, Solomon, Daniel A., Soothill, James ... Hatfull, Graham F. (2023). Phage therapy of Mycobacterium infections: compassionate use of phages in 20 patients with drug-resistant mycobacterial disease. Clinical Infectious Diseases, 76 (1), 103-112. doi: 10.1093/cid/ciac453
Imani, Sahand, Fitzgerald, Dominic A., Robinson, Paul D., Selvadurai, Hiran, Sandaradura, Indy and Lai, Tony (2022). Personalized tobramycin dosing in children with cystic fibrosis: a comparative clinical evaluation of log-linear and Bayesian methods. The Journal of Antimicrobial Chemotherapy, 77 (12), 3358-3366. doi: 10.1093/jac/dkac324
Ultrafine particle exposure and biomarkers of effect on small airways in children
Robinson, Paul D., Salimi, Farhad, Cowie, Christine T., Clifford, Samuel, King, Gregory G., Thamrin, Cindy, Hardaker, Kate, Mazaheri, Mandana, Morawska, Lidia, Toelle, Brett G. and Marks, Guy B. (2022). Ultrafine particle exposure and biomarkers of effect on small airways in children. Environmental Research, 214 (Part 1) 113860. doi: 10.1016/j.envres.2022.113860
Older age at Fontan completion is associated with reduced lung volumes and increased lung reactance
Laohachai, Karina, Badal, Tanya, Thamrin, Cindy, Robinson, Paul D., Kennedy, Brendan, Rice, Kathryn, Selvadurai, Hiran, Weintraub, Robert, Cordina, Rachael, d'Udekem, Yves and Ayer, Julian (2022). Older age at Fontan completion is associated with reduced lung volumes and increased lung reactance. International Journal of Cardiology, 364, 38-43. doi: 10.1016/j.ijcard.2022.06.037
Bozier, Jack, Jeagal, Edward, Robinson, Paul D., Prisk, G. Kim, Chapman, David G., King, Gregory G., Thamrin, Cindy and Rutting, Sandra (2022). The effect of oxygen and carbon dioxide cross-sensitivity sensor error in the Eco Medics Exhalyzer D device on measures of conductive and acinar airway function. ERJ Open Research, 8 (3) 00614-2021. doi: 10.1183/23120541.00614-2021
Robinson, Paul D., Jensen, Renee, Seeto, Ryan A., Stanojevic, Sanja, Saunders, Clare, Short, Christopher, Davies, Jane C. and Ratjen, Felix (2022). Impact of cross-sensitivity error correction on representative nitrogen-based multiple breath washout data from clinical trials. Journal of Cystic Fibrosis, 21 (3), e204-e207. doi: 10.1016/j.jcf.2021.08.033
Contemporary N2 and SF6 multiple breath washout in infants and toddlers with cystic fibrosis
Sandvik, Rikke M., Gustafsson, Per M., Lindblad, Anders, Buchvald, Frederik, Olesen, Hanne V., Olsen, Jørgen H., Skov, Marianne, Schmidt, Marika N., Thellefsen, Mette R., Robinson, Paul D., Rubak, Sune, Pressler, Tacjana and Nielsen, Kim G. (2022). Contemporary N2 and SF6 multiple breath washout in infants and toddlers with cystic fibrosis. Pediatric Pulmonology, 57 (4), 945-955. doi: 10.1002/ppul.25830
Clinical significance and applications of oscillometry
Kaminsky, David A., Simpson, Shannon J., Berger, Kenneth I., Calverley, Peter, de Melo, Pedro L., Dandurand, Ronald, Dellacà, Raffaele L., Farah, Claude S., Farré, Ramon, Hall, Graham L., Ioan, Iulia, Irvin, Charles G., Kaczka, David W., King, Gregory G., Kurosawa, Hajime, Lombardi, Enrico, Maksym, Geoffrey N., Marchal, François, Oostveen, Ellie, Oppenheimer, Beno W., Robinson, Paul D., van den Berge, Maarten and Thamrin, Cindy (2022). Clinical significance and applications of oscillometry. European Respiratory Review, 31 (163) 210208, 210208. doi: 10.1183/16000617.0208-2021
Issues affecting young people with asthma through the transition period to adult care
Robinson, Paul D., Jayasuriya, Geshani, Haggie, Stuart, Uluer, Ahmet Z., Gaffin, Jonathan M. and Fleming, Louise (2022). Issues affecting young people with asthma through the transition period to adult care. Paediatric Respiratory Reviews, 41, 30-39. doi: 10.1016/j.prrv.2021.09.005
Technical Standards for Respiratory Oscillometry and Bronchodilator Response CutOffs
Thamrin, Cindy, Robinson, Paul D., Farah, Claude S. and King, Gregory G. (2022). Technical Standards for Respiratory Oscillometry and Bronchodilator Response CutOffs. European Respiratory Journal, 59 (3) 2102663, 2102663. doi: 10.1183/13993003.02663-2021
Transition to adult care in cystic fibrosis: The challenges and the structure
Singh, Jagdev, Towns, Susan, Jayasuriya, Geshani, Hunt, Sharon, Simonds, Sharon, Boyton, Christie, Middleton, Anna, Kench, Andrea, Pandit, Chetan, Keatley, Lucy R., Chien, Jimmy, Bishop, Jennifer, Song, Yang, Robinson, Paul, Selvadurai, Hiran, Middleton, Peter G. and Fitzgerald, Dominic A. (2022). Transition to adult care in cystic fibrosis: The challenges and the structure. Paediatric Respiratory Reviews, 41, 23-29. doi: 10.1016/j.prrv.2020.07.009
Update in management of paediatric primary spontaneous pneumothorax
Lieu, Nathan, Ngo, Peter, Chennapragada, S. Murthy, Fitzgerald, Dominic A., Karpelowsky, Jonathan, Pandit, Chetan, Selvadurai, Hiran and Robinson, Paul D. (2022). Update in management of paediatric primary spontaneous pneumothorax. Paediatric Respiratory Reviews, 41, 73-79. doi: 10.1016/j.prrv.2021.08.001
De Queiroz Andrade, Ediane, Bayfield, Katie J., Blaxland, Anneliese, Wong, Alexander, De Gouveia Belinelo, Patricia, Sly, Peter D., Collison, Adam, Murphy, Vanessa E., Gibson, Peter, Mattes, Joerg and Robinson, Paul D. (2022). Exposure to 4% SF 6 during multiple breath washout affects subsequent infant tidal breathing analysis. Pediatric Pulmonology, 57 (4), 1089-1091. doi: 10.1002/ppul.25820
Short, Christopher, Semple, Thomas, Saunders, Clare, Hughes, Dominic, Irving, Samantha, Gardener, Laura, Rosenthal, Mark, Robinson, Paul D. and Davies, Jane C. (2022). A Short extension to multiple breath washout provides additional signal of distal airway disease in people with CF: a pilot study. Journal of Cystic Fibrosis, 21 (1), 146-154. doi: 10.1016/j.jcf.2021.06.013
Da Silva Sena, Carla Rebeca, de Queiroz Andrade, Ediane, de Gouveia Belinelo, Patricia, Percival, Elizabeth, Prangemeier, Benjamin, O'Donoghue, Christopher, Terry, Sandrine, Burke, Tanya, Gunning, William, Murphy, Vanessa E., Robinson, Paul D., Sly, Peter D., Gibson, Peter G., Collison, Adam M. and Mattes, Joerg (2021). Higher exhaled nitric oxide at 6 weeks of age is associated with less bronchiolitis and wheeze in the first 12 months of age. Thorax, 77 (11), thoraxjnl-2021. doi: 10.1136/thoraxjnl-2021-217299
As-needed budesonide-formoterol for adolescents with mild asthma: Importance of lung function
Shanthikumar, Shivanthan and Robinson, Paul D. (2021). As-needed budesonide-formoterol for adolescents with mild asthma: Importance of lung function. Journal of Allergy and Clinical Immunology: In Practice, 9 (11), 4178-4178. doi: 10.1016/j.jaip.2021.07.059
Controlled versus free breathing for multiple-breath nitrogen washout in asthma
Handley, Blake M., Bozier, Jack, Jeagal, Edward, Rutting, Sandra, Schoeffel, Robin E., Robinson, Paul D., King, Gregory G., Milne, Stephen and Thamrin, Cindy (2021). Controlled versus free breathing for multiple-breath nitrogen washout in asthma. ERJ Open Research, 7 (4) 00487-2021, 00487-2021. doi: 10.1183/23120541.00487-2021
Multiple breath washout: measuring early manifestations of lung pathology
Stanojevic, Sanja, Bowerman, Cole and Robinson, Paul (2021). Multiple breath washout: measuring early manifestations of lung pathology. Breathe, 17 (3) 210016, 210016. doi: 10.1183/20734735.0016-2021
Nitrogen multiple-breath washout (N2-MBW) - Historical, technical, and clinical aspects
Gustafsson, P., Kjellberg, S. and Robinson, P. D. (2021). Nitrogen multiple-breath washout (N2-MBW) - Historical, technical, and clinical aspects . Atemwegs- und Lungenkrankheiten, 47 (8), 349-365. doi: 10.5414/ATX02577
Forno, Erick, Abman, Steven H., Singh, Jagdev, Robbins, Mary E., Selvadurai, Hiran, Schumacker, Paul T. and Robinson, Paul D. (2021). Update in pediatrics 2020. American Journal of Respiratory and Critical Care Medicine, 204 (3), 274-284. doi: 10.1164/rccm.202103-0605UP
Tobramycin and Colistin display anti-inflammatory properties in CuFi-1 cystic fibrosis cell line
Sheikh, Zara, Bradbury, Peta, Reekie, Tristan A., Pozzoli, Michele, Robinson, Paul D., Kassiou, Michael, Young, Paul M., Ong, Hui Xin and Traini, Daniela (2021). Tobramycin and Colistin display anti-inflammatory properties in CuFi-1 cystic fibrosis cell line. European Journal of Pharmacology, 902 174098, 174098. doi: 10.1016/j.ejphar.2021.174098
Murphy, Vanessa E., Karmaus, Wilfried, Mattes, Joerg, Brew, Bronwyn K., Collison, Adam, Holliday, Elizabeth, Jensen, Megan E., Morgan, Geoffrey G., Zosky, Graeme R., McDonald, Vanessa M., Jegasothy, Edward, Robinson, Paul D. and Gibson, Peter G. (2021). Exposure to stress and air pollution from bushfires during pregnancy: Could epigenetic changes explain effects on the offspring?. International Journal of Environmental Research and Public Health, 18 (14) 7465, 1-12. doi: 10.3390/ijerph18147465
Sandvik, Rikke M., Gustafsson, Per M., Lindblad, Anders, Robinson, Paul D. and Nielsen, Kim G. (2021). Improved agreement between N2 and SF6 multiple-breath washout in healthy infants and toddlers with improved EXHALYZER D sensor performance. Journal of Applied Physiology, 131 (1), 107-118. doi: 10.1152/japplphysiol.00129.2021
de Gouveia Belinelo, Patricia, Collison, Adam M., Murphy, Vanessa E., Robinson, Paul D., Jesson, Kathryn, Hardaker, Kate, de Queiroz Andrade, Ediane, Oldmeadow, Christopher, Martins Costa Gomes, Gabriela, Sly, Peter D., Usemann, Jakob, Appenzeller, Rhea, Gorlanova, Olga, Fuchs, Oliver, Latzin, Philipp, Gibson, Peter G., Frey, Urs and Mattes, Joerg (2021). Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts. Thorax, 76 (10), 996-1001. doi: 10.1136/thoraxjnl-2020-215526
Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis
Bayfield, Katie J., Douglas, Tonia A., Rosenow, Tim, Davies, Jane Carolyn, Elborn, Stuart J., Mall, Marcus, Paproki, Anthony, Ratjen, Felix, Sly, Peter D., Smyth, Alan R., Stick, Stephen, Wainwright, Claire E. and Robinson, Paul D. (2021). Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis. Thorax, 76 (12), 1-11. doi: 10.1136/thoraxjnl-2020-216085
Reply: Fixed breathing protocols in multiple-breath-washout testing: Truly an option in children?
Verbanck, Sylvia, Schuermans, Daniel, Paiva, Manuel, Robinson, Paul D. and Vanderhelst, Eef (2021). Reply: Fixed breathing protocols in multiple-breath-washout testing: Truly an option in children?. European Respiratory Journal, 57 (3) 2000189, 2100189. doi: 10.1183/13993003.00189-2021
Mitigating increased variability of multiple breath washout indices due to tidal breathing
Verbanck, Sylvia, Schuermans, Daniel, Paiva, Manuel, Robinson, Paul D and Vanderhelst, Eef (2021). Mitigating increased variability of multiple breath washout indices due to tidal breathing. European Respiratory Journal, 57 (2) 2002765, 2002765. doi: 10.1183/13993003.02765-2020
Da Silva Sena, Carla R., Morten, Matthew, Meredith, Joseph, Kepreotes, Elizabeth, Murphy, Vanessa, Gibson, Peter, Robinson, Paul, Sly, Peter, Whitehead, Bruce, Karmaus, Wilfried, Collison, Adam and Mattes, Joerg (2021). Rhinovirus bronchiolitis, maternal asthma, and the development of asthma and lung function impairments. Pediatric Pulmonology, 56 (2), 362-370. doi: 10.1002/ppul.25165
Controlled versus free breathing for multiple breath nitrogen washout in healthy adults
Handley, Blake M., Jeagal, Edward, Schoeffel, Robin E., Badal, Tanya, Chapman, David G., Farrow, Catherine E., King, Gregory G., Robinson, Paul D., Milne, Stephen and Thamrin, Cindy (2021). Controlled versus free breathing for multiple breath nitrogen washout in healthy adults. ERJ Open Research, 7 (1) 00435-2020, 1-10. doi: 10.1183/23120541.00435-2020
Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age
Martins Costa Gomes, Gabriela, de Gouveia Belinelo, Patricia, Starkey, Malcolm R, Murphy, Vanessa E, Hansbro, Philip M, Sly, Peter D, Robinson, Paul D, Karmaus, Wilfried, Gibson, Peter G, Mattes, Joerg and Collison, Adam M (2021). Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age. Clinical and Translational Immunology, 10 (7) e1296. doi: 10.1002/cti2.1296
Further considerations on normative data for multiple breath washout outcomes
Bayfield, Katie J., Shaar, Aida and Robinson, Paul D. (2021). Further considerations on normative data for multiple breath washout outcomes. European Respiratory Journal, 57 (4), 2004536. doi: 10.1183/13993003.04536-2020
Haggie, Stuart, Gunasekera, Hasantha, Pandit, Chetan, Selvadurai, Hiran, Robinson, Paul and Fitzgerald, Dominic A. (2020). Paediatric empyema: worsening disease severity and challenges identifying patients at increased risk of repeat intervention. Archives of Disease in Childhood, 105 (9), 886-890. doi: 10.1136/archdischild-2019-318219
The need for physiological phenotyping to develop new drugs for airways disease
Chapman, David G, King, Gregory G, Robinson, Paul D, Farah, Claude S and Thamrin, Cindy (2020). The need for physiological phenotyping to develop new drugs for airways disease. Pharmacological Research, 159 105029, 1-8. doi: 10.1016/j.phrs.2020.105029
End-expiratory lung volume remains stable during N2 MBW in healthy sleeping infants
Gustafsson, Per M., Kadar, Laszlo, Kjellberg, Sanna, Andersson, Lena, Lindblad, Anders and Robinson, Paul D. (2020). End-expiratory lung volume remains stable during N2 MBW in healthy sleeping infants. Physiological Reports, 8 (16) e14477, 1-9. doi: 10.14814/phy2.14477
Integrating the multiple breath washout test into international multicentre trials
Saunders, Clare, Jensen, Renee, Robinson, Paul D., Stanojevic, Sanja, Klingel, Michelle, Short, Christopher, Davies, Jane C. and Ratjen, Felix (2020). Integrating the multiple breath washout test into international multicentre trials. Journal of Cystic Fibrosis, 19 (4), 602-607. doi: 10.1016/j.jcf.2019.11.006
Bortoluzzi, Carla F., Pontello, Eleonora, Pintani, Emily, de Winter-de Groot, Karin M., D'Orazio, Ciro, Assael, Baroukh M., Hunink, M.G. Myriam, Tiddens, Harm A.W.M., Caudri, Daan, Belessis, Y., Bremont, F., Bui, S., Casciaro, R., Cavicchi, M. C., Cox, D. M., Da Dalt, L., De Gregorio, F., Dubus, J. C., Gartner, S., Geerdink, M., Hansen, C. R., Honková, L., Jenkins, L. E., Jung, A., Karpati, F., Mainguy, C., Möller, A., Neri, A. S., Pressler, T. ... Vazquez, C. (2020). The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease. Journal of Cystic Fibrosis, 19 (4), 641-646. doi: 10.1016/j.jcf.2019.08.005
Bronchopulmonary dysplasia: a review of the pulmonary sequelae in the post-surfactant era
Haggie, Stuart, Robinson, Paul, Selvadurai, Hiran and Fitzgerald, Dominic A (2020). Bronchopulmonary dysplasia: a review of the pulmonary sequelae in the post-surfactant era. Journal of Paediatrics and Child Health, 56 (5), 680-689. doi: 10.1111/jpc.14878
Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life
Harvey, Soriah M., Murphy, Vanessa E., Gibson, Peter G., Collison, Adam, Robinson, Paul, Sly, Peter D., Mattes, Joerg and Jensen, Megan E. (2020). Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life. Pediatric Pulmonology, 55 (7) ppul.24756, 1690-1696. doi: 10.1002/ppul.24756
Clinical and lung function outcomes in a cohort of children with severe asthma
De Gouveia Belinelo, Patricia, Nielsen, Aleisha, Goddard, Bernadette, Platt, Lauren, Da Silva Sena, Carla Rebeca, Robinson, Paul D., Whitehead, Bruce, Hilton, Jodi, Gulliver, Tanya, Roddick, Laurence, Pearce, Kasey, Murphy, Vanessa E., Gibson, Peter G., Collison, Adam and Mattes, Joerg (2020). Clinical and lung function outcomes in a cohort of children with severe asthma. BMC Pulmonary Medicine, 20 (1) 66, 1-9. doi: 10.1186/s12890-020-1101-6
Robinson, Paul D., Kadar, Laszlo, Lindblad, Anders and Gustafsson, Per M. (2019). Effect of change of body position in spontaneous sleeping healthy infants on SF6-based multiple breath washout. European Respiratory Journal, 54 (6) 1900259, 1900259. doi: 10.1183/13993003.00259-2019
HabITec: A Sociotechnical Space for Promoting the Application of Technology to Rehabilitation
Kendall, Elizabeth, Oh, Soo, Amsters, Delena, Whitehead, Mary, Hua, Justin, Robinson, Paul, Palipana, Dinesh, Gall, Andrew, Cheung, Ming, Potter, Leigh Ellen, Smith, Derek and Lightfoot, Brett (2019). HabITec: A Sociotechnical Space for Promoting the Application of Technology to Rehabilitation. Societies, 9 (4) ARTN 74, 74. doi: 10.3390/soc9040074
Haggie, Stuart, Fitzgerald, Dominic A., Pandit, Chetan, Selvadurai, Hiran, Robinson, Paul, Gunasekera, Hasantha and Britton, Philip (2019). Increasing rates of pediatric empyema and disease severity with predominance of serotype 3 S. pneumonia: an Australian single-center, retrospective cohort 2011 to 2018. Pediatric Infectious Disease Journal, E320-E325. doi: 10.1097/INF.0000000000002474
Use of non-invasive ventilation in children with congenital tracheal stenosis
Pellen, G., Pandit, C., Castro, C., Robinson, P., Seton, C., Fitzgerald, D. A., Waters, K. and Cheng, A. T. (2019). Use of non-invasive ventilation in children with congenital tracheal stenosis. International Journal of Pediatric Otorhinolaryngology, 127 109672, 1-4. doi: 10.1016/j.ijporl.2019.109672
Long-term morbidity of respiratory viral infections during chemotherapy in children with leukaemia
Lin, Beryl, Kennedy, Brendan, McBride, Jamie, Dalla-Pozza, Luciano, Trahair, Toby, McCowage, Geoffrey, Coward, Emma, Plush, Leanne, Robinson, Paul D., Hardaker, Kate, Widger, John, Ng, Anthea, Jaffe, Adam and Selvadurai, Hiran (2019). Long-term morbidity of respiratory viral infections during chemotherapy in children with leukaemia. Pediatric Pulmonology, 54 (11), 1821-1829. doi: 10.1002/ppul.24456
Hardaker, K. M., Panda, H., Hulme, K., Wong, A., Coward, E., Cooper, P., Fitzgerald, D. A., Pandit, C., Towns, S., Selvadurai, H. and Robinson, P. D. (2019). Abnormal preschool Lung Clearance Index (LCI) reflects clinical status and predicts lower spirometry later in childhood in cystic fibrosis. Journal of Cystic Fibrosis, 18 (5), 721-727. doi: 10.1016/j.jcf.2019.02.007
Does asplenia make some immunisations obligatory?
Isaacs, David, Preisz, Anne, Britton, Philip N, Kilham, Henry A, Robinson, Paul D and Farrow, Glendon (2019). Does asplenia make some immunisations obligatory?. Journal of Paediatrics and Child Health, 55 (5), 499-501. doi: 10.1111/jpc.14418
Home-based forced Oscillation technique day-to-day variability in Pediatric Asthma
Wong, Alexander, Hardaker, Kate, Field, Penny, Huvanandana, Jacqueline, King, Gregory G., Reddel, Helen, Selvadurai, Hiran, Thamrin, Cindy and Robinson, Paul D. (2019). Home-based forced Oscillation technique day-to-day variability in Pediatric Asthma. American Journal of Respiratory and Critical Care Medicine, 199 (9), 1156-1160. doi: 10.1164/rccm.201809-1659LE
Question 13: can we predict the need for lung transplantation in children with cystic fibrosis?
Piper, Nick, Bajic, Marko, Selvadurai, Hiran, Robinson, Paul, Zurynski, Yvonne and Fitzgerald, Dominic A. (2019). Question 13: can we predict the need for lung transplantation in children with cystic fibrosis?. Paediatric Respiratory Reviews, 30, 30-33. doi: 10.1016/j.prrv.2019.02.002
Disease caused by non-tuberculous mycobacteria in children with cystic fibrosis
Lu, Mimi, Saddi, Vishal, Britton, Philip N., Selvadurai, Hiran, Robinson, Paul D., Pandit, Chetan, Marais, Ben J. and Fitzgerald, Dominic A. (2019). Disease caused by non-tuberculous mycobacteria in children with cystic fibrosis. Paediatric Respiratory Reviews, 29, 42-52. doi: 10.1016/j.prrv.2018.05.001
Managing Asthma in Pregnancy (MAP) trial: FeNO levels and childhood asthma
Morten, Matthew, Collison, Adam, Murphy, Vanessa E., Barker, Daniel, Oldmeadow, Christopher, Attia, John, Meredith, Joseph, Powell, Heather, Robinson, Paul D., Sly, Peter D., Gibson, Peter G. and Mattes, Joerg (2018). Managing Asthma in Pregnancy (MAP) trial: FeNO levels and childhood asthma. The Journal of Allergy and Clinical Immunology, 142 (6), 1765-1772. doi: 10.1016/j.jaci.2018.02.039
Spontaneous pneumothorax in a young child with pulmonary tuberculosis
Hulme, Kathryn M., Isaacs, David, Marais, Ben J. and Robinson, Paul D. (2018). Spontaneous pneumothorax in a young child with pulmonary tuberculosis. Pediatric Infectious Disease Journal, 37 (12), E343-E345. doi: 10.1097/INF.0000000000002018
Surgery in nontuberculous mycobacteria pulmonary disease
Lu, Mimi, Fitzgerald, Dominic, Karpelowsky, Jonathan, Selvadurai, Hiran, Pandit, Chetan, Robinson, Paul and Marais, Ben J. (2018). Surgery in nontuberculous mycobacteria pulmonary disease. Breathe, 14 (4), 288-301. doi: 10.1183/20734735.027218
Contribution of peripheral airway function to changes in FEV1/FVC and RV/ TLC with aging
Htun, Christopher, Pope, Alun, Lahzami, Samir, Luo, Darren, Schoeffel, Robin E., Farrow, Catherine E., Phillips, Craig L., Robinson, Paul D. and King, Gregory G. (2018). Contribution of peripheral airway function to changes in FEV1/FVC and RV/ TLC with aging. Journal of Applied Physiology, 125 (5), 1378-1383. doi: 10.1152/japplphysiol.00114.2018
Utility of single versus multiple breath washout in adult asthma
Kjellberg, S., Viklund, E., Robinson, P. D., Zetterström, O., Olin, A. C. and Gustafsson, P. (2018). Utility of single versus multiple breath washout in adult asthma. Clinical Physiology and Functional Imaging, 38 (6), 936-943. doi: 10.1111/cpf.12503
Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements
Robinson, Paul D., Lum, Sooky, Moore, Courtney, Hardaker, Kate M., Benseler, Nick, Aurora, Paul, Cooper, Peter, Fitzgerald, Dominic, Jensen, Renee, McDonald, Reginald, Selvadurai, Hiran, Ratjen, Felix and Stanojevic, Sanja (2018). Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements. Journal of Cystic Fibrosis, 17 (4), 511-517. doi: 10.1016/j.jcf.2018.01.003
Ventilation inhomogeneity and NO and CO diffusing capacity in ex-premature school children
Sørensen, Jesper Kiehn, Buchvald, Frederik, Berg, Anna Korsgaard, Robinson, Paul D. and Nielsen, Kim Gjerum (2018). Ventilation inhomogeneity and NO and CO diffusing capacity in ex-premature school children. Respiratory Medicine, 140, 94-100. doi: 10.1016/j.rmed.2018.06.006
Preschool multiple-breath washout testing an official American thoracic society technical statement
Robinson, Paul D., Latzin, Philipp, Ramsey, Kathryn A., Stanojevic, Sanja, Aurora, Paul, Davis, Stephanie D., Gappa, Monika, Hall, Graham L., Horsley, Alex, Jensen, Renee, Lum, Sooky, Milla, Carlos, Nielsen, Kim G., Pittman, Jessica E., Rosenfeld, Margaret, Singer, Florian, Subbarao, Padmaja, Gustafsson, Per M. and Ratjen, Felix (2018). Preschool multiple-breath washout testing an official American thoracic society technical statement. American Journal of Respiratory and Critical Care Medicine, 197 (5), e1-e19. doi: 10.1164/rccm.201801-0074ST
Svedberg, Marcus, Gustafsson, Per M., Robinson, Paul D., Rosberg, Monica and Lindblad, Anders (2018). Variability of lung clearance index in clinically stable cystic fibrosis lung disease in school age children. Journal of Cystic Fibrosis, 17 (2), 236-241. doi: 10.1016/j.jcf.2017.08.004
Gustafsson, Per M., Bengtsson, Lovisa, Lindblad, Anders and Robinson, Paul D. (2017). The effect of inert gas choice on multiple breath washout in healthy infants: differences in lung function outcomes and breathing pattern. Journal of Applied Physiology, 123 (6), 1545-1554. doi: 10.1152/japplphysiol.00524.2017
Pham, Thuy T., Leong, Philip H. W., Robinson, Paul D., Gutzler, Thomas, Jee, Adelle S., King, Gregory G. and Thamrin, Cindy (2017). Automated quality control of forced oscillation measurements: respiratory artifact detection with advanced feature extraction. Journal of Applied Physiology, 123 (4), 781-789. doi: 10.1152/japplphysiol.00726.2016
Dunn, Ashlee, Pearce, Kasey, Callister, Robin, Collison, Adam, Morten, Matthew, Mandaliya, Payal, Platt, Lauren, Dascombe, Ben, Kumar, Rajendra, Selvadurai, Hiran, Robinson, Paul D. and Mattes, Joerg (2017). Exercise capacity is not decreased in children who have undergone lung resection early in life for congenital thoracic malformations compared to healthy age-matched children. Pediatric Pulmonology, 52 (10), 1340-1348. doi: 10.1002/ppul.23772
Tonga, Katrina O., Robinson, Paul D., Farah, Claude S., King, Greg G. and Thamrin, Cindy (2017). In vitro and in vivo functional residual capacity comparisons between multiple-breath nitrogen washout devices. ERJ Open Research, 3 (4) 00011-2017, 1-8. doi: 10.1183/23120541.00011-2017
Ohn, Mon, Robinson, Paul, Selvadurai, Hiran and Fitzgerald, Dominic A. (2017). Question 11: how should Allergic Bronchopulmonary Aspergillosis [ABPA] be managed in Cystic Fibrosis?. Paediatric Respiratory Reviews, 24, 35-38. doi: 10.1016/j.prrv.2016.10.001
Determinants of peripheral airway function in adults with and without asthma
Robinson, Paul D., King, Gregory G., Sears, Malcolm R., Hong, Chuen Y. and Hancox, Robert J. (2017). Determinants of peripheral airway function in adults with and without asthma. Respirology, 22 (6), 1110-1117. doi: 10.1111/resp.13045
Respiratory artefact removal in forced oscillation measurements: a machine learning approach
Pham, Thuy T., Thamrin, Cindy, Robinson, Paul D., McEwan, Alistair L. and Leong, Philip H. W. (2017). Respiratory artefact removal in forced oscillation measurements: a machine learning approach. IEEE Transactions on Biomedical Engineering, 64 (8) 7453188, 1679-1687. doi: 10.1109/TBME.2016.2554599
Is twice the duration of washout sufficient time between multiple breath nitrogen washout tests?
Hardaker, Kate M., Gustafsson, Per, Cooper, Peter, Fitzgerald, Dominic, Selvadurai, Hiran and Robinson, Paul D. (2017). Is twice the duration of washout sufficient time between multiple breath nitrogen washout tests?. European Respiratory Journal, 49 (2) 1501832. doi: 10.1183/13993003.01832-2015
Feasibility of squeezing multiple breath washout testing into busy clinical laboratories
Robinson, Paul D. (2016). Feasibility of squeezing multiple breath washout testing into busy clinical laboratories. Pediatric Pulmonology, 51 (12), 1271-1273. doi: 10.1002/ppul.23560
Specific airway resistance in preschool children: Why not panting after all?
Ioan, Iulia, Silvia, Demoulin-Alexikova, Coutier, Laurianne, Bonabel, Claude, Kirkby, Jane, Nielsen, Kim G., Tomalak, Waldemar, Thompson, Bruce, Schweitzer, Cyril, Robinson, Paul D. and Marchal, François (2016). Specific airway resistance in preschool children: Why not panting after all?. European Respiratory Journal, 48 (6), 1804-1807. doi: 10.1183/13993003.01302-2016
Gustafsson, P. M., Robinson, P. D., Lindblad, A. and Oberli, D. (2016). Novel methodology to perform sulfur hexafluoride (SF6)-based multiplebreath wash-in and washout in infants using current commercially available equipment. Journal of Applied Physiology, 121 (5), 1087-1097. doi: 10.1152/japplphysiol.00115.2016
Hew, M., Gillman, A., Sutherland, M., Wark, P., Bowden, J., Guo, M., Reddel, H. K., Jenkins, C., Marks, G. B., Thien, F., Rimmer, J., Katsoulotos, G. P., Cook, M., Yang, I., Katelaris, C., Bowler, S., Langton, D., Wright, C., Bint, M., Yozghatlian, V., Burgess, S., Sivakumaran, P., Yan, K. Y., Kritikos, V., Peters, M., Baraket, M., Aminazad, A., Robinson, P., Jaffe, A. ... Gibson, P. G. (2016). Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria. Clinical and Experimental Allergy, 46 (11), 1407-1415. doi: 10.1111/cea.12774
Groves, Tyler, Robinson, Paul and Fitzgerald, Dominic A. (2016). Question 7: for an infant with an equivocal sweat chloride following newborn screening, how likely is a diagnosis of cystic fibrosis?. Paediatric Respiratory Reviews, 20, 48-50. doi: 10.1016/j.prrv.2015.11.007
Clinical characteristics of adult asthma associated with small airway dysfunction
Kjellberg, S., Houltz, B. K., Zetterström, O., Robinson, P. D. and Gustafsson, Per M. (2016). Clinical characteristics of adult asthma associated with small airway dysfunction. Respiratory Medicine, 117, 92-102. doi: 10.1016/j.rmed.2016.05.028
Gibson, P. G., Reddel, H., McDonald, V. M., Marks, G., Jenkins, C., Gillman, A., Upham, J., Sutherland, M., Rimmer, J., Thien, F., Katsoulotos, G. P., Cook, M., Yang, I., Katelaris, C., Bowler, S., Langton, D., Robinson, P., Wright, C., Yozghatlian, V., Burgess, S., Sivakumaran, P., Jaffe, A., Bowden, J., Wark, P. A., Yan, K. Y., Kritikos, V., Peters, M., Hew, M., Aminazad, A. ... Guo, M. (2016). Effectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry. Internal Medicine Journal, 46 (9), 1054-1062. doi: 10.1111/imj.13166
A systematic approach to multiple breath nitrogen washout test quality
Jensen, Renee, Stanojevic, Sanja, Klingel, Michelle, Pizarro, Maria Ester, Hall, Graham L., Ramsey, Kathryn, Foong, Rachel, Saunders, Clare, Robinson, Paul D., Webster, Hailey, Hardaker, Kate, Kane, Mica and Ratjen, Felix (2016). A systematic approach to multiple breath nitrogen washout test quality. PLoS ONE, 11 (6) e0157523, 1-9. doi: 10.1371/journal.pone.0157523
Question 6: is there a role for Mannose-Binding Lectin measurement in Cystic Fibrosis management?
Prentice, Bernadette, McKay, Karen, Selvadurai, Hiran, Robinson, Paul D., Abel, Francois and Fitzgerald, Dominic A. (2016). Question 6: is there a role for Mannose-Binding Lectin measurement in Cystic Fibrosis management?. Paediatric Respiratory Reviews, 19, 46-48. doi: 10.1016/j.prrv.2015.09.008
Multiple breath washout: From renaissance to enlightenment?
Thamrin, Cindy, Hardaker, Kate and Robinson, Paul D. (2016). Multiple breath washout: From renaissance to enlightenment?. Pediatric Pulmonology, 51 (5), 447-449. doi: 10.1002/ppul.23316
Robinson, Paul D., Stocks, Janet, Marchal, Francois, Nielsen, Kim G., Thompson, Bruce R., Tomalak, Waldemar and Kirkby, Jane (2015). Poor standardisation of plethysmographic specific airways resistance measurement despite widespread use. European Respiratory Journal, 46 (6), 1811-1814. doi: 10.1183/13993003.00377-2015
Stratifying cystic fibrosis risk for newborn screen infants with equivocal sweat chloride levels
Groves, Tyler M., Robinson, Paul and Fitzgerald, Dominic A. (2015). Stratifying cystic fibrosis risk for newborn screen infants with equivocal sweat chloride levels. Pediatrics, 136 (5). doi: 10.1542/peds.2015-2786A
Ciclesonide-induced bronchospasm: an important but preventable side effect
Mandaliya, Payal H., Kennedy, Brendan, van Asperen, Peter and Robinson, Paul D. (2015). Ciclesonide-induced bronchospasm: an important but preventable side effect. Medical Journal of Australia, 203 (5), 233-233e.1. doi: 10.5694/mja15.00014
Robinson, Paul D., Spencer, Helen and Aurora, Paul (2015). Impact of lung function interpretation approach on pediatric bronchiolitis obliterans syndrome diagnosis after lung transplantation. Journal of Heart and Lung Transplantation, 34 (8) 5991, 1082-1088. doi: 10.1016/j.healun.2015.03.010
Long-term outcomes of children with intermediate sweat chloride values in infancy
Groves, Tyler, Robinson, Paul, Wiley, Veronica and Fitzgerald, Dominic A. (2015). Long-term outcomes of children with intermediate sweat chloride values in infancy. Journal of Pediatrics, 166 (6), 1469-1474.e3. doi: 10.1016/j.jpeds.2015.01.052
Subbarao, Padmaja, Milla, Carlos, Aurora, Paul, Davies, Jane C., Davis, Stephanie D., Hall, Graham L., Heltshe, Sonya, Latzin, Philipp, Lindblad, Anders, Pittman, Jessica E., Robinson, Paul D., Rosenfeld, Margaret, Singer, Florian, Starner, Tim D., Ratjen, Felix and Morgan, Wayne (2015). Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop report. Annals of the American Thoracic Society, 12 (6), 932-939. doi: 10.1513/AnnalsATS.201501-021FR
Ventilation inhomogeneities in children with congenital thoracic malformations
Mandaliya, Payal H., Morten, Matthew, Kumar, Rajendra, James, Alan, Deshpande, Aniruddh, Murphy, Vanessa E., Gibson, Peter G., Whitehead, Bruce, Robinson, Paul and Mattes, Joerg (2015). Ventilation inhomogeneities in children with congenital thoracic malformations. BMC Pulmonary Medicine, 15 (1) 25. doi: 10.1186/s12890-015-0023-1
A pilot study of inhaled dry-powder mannitol during cystic fibrosis-related pulmonary exacerbation
Middleton, Anna, Robinson, Paul D., McKay, Karen, Jaffe, Adam and Selvadurai, Hiran (2015). A pilot study of inhaled dry-powder mannitol during cystic fibrosis-related pulmonary exacerbation. European Respiratory Journal, 45 (2), 541-544. doi: 10.1183/09031936.00137814
Ezz, Wafaa Nabil, Mazaheri, Mandana, Robinson, Paul, Johnson, Graham R., Clifford, Samuel, He, Congrong, Morawska, Lidia and Marks, Guy B. (2015). Ultrafine Particles from Traffic Emissions and Children's Health (UPTECH) in Brisbane, Queensland (Australia): Study Design and Implementation. International Journal of Environmental Research and Public Health, 12 (2), 1687-1702. doi: 10.3390/ijerph120201687
Chloral hydrate sedation for infant pulmonary function testing
Ren, Clement L., Robinson, Paul and Ranganathan, Sarath (2014). Chloral hydrate sedation for infant pulmonary function testing. Pediatric Pulmonology, 49 (12), 1251-1252. doi: 10.1002/ppul.23012
Viral infections and asthma: An inflammatory interface?
Oliver, Brian G.G., Robinson, Paul, Peters, Mathew and Black, Judy (2014). Viral infections and asthma: An inflammatory interface?. European Respiratory Journal, 44 (6), 1666-1681. doi: 10.1183/09031936.00047714
Robinson, Paul D., Brown, Nathan J., Turner, Martin, Van Asperen, Peter, Selvadurai, Hiran and King, Gregory G. (2014). Increased day-to-day variability of forced oscillatory resistance in poorly controlled or persistent pediatric asthma. Chest, 146 (4), 974-981. doi: 10.1378/chest.14-0288
Slow and fast lung compartments in cystic fibrosis measured by nitrogen multiple-breath washout
Gustafsson, P. M., Robinson, P. D., Gilljam, M., Lindblad, A. and Houltz, B. K. (2014). Slow and fast lung compartments in cystic fibrosis measured by nitrogen multiple-breath washout. Journal of Applied Physiology, 117 (7), 720-729. doi: 10.1152/japplphysiol.01274.2013
Age-specific management of asthma in children
Van Asperen, Peter and Robinson, Paul (2014). Age-specific management of asthma in children. Medicine Today, 15 (9), 14-28.
Hime, Neil J, Fitzgerald, Dominic, Robinson, Paul, Selvadurai, Hiran, Van Asperen, Peter, Jaffé, Adam and Zurynski, Yvonne (2014). Childhood interstitial lung disease due to surfactant protein C deficiency: Frequent use and costs of hospital services for a single case in Australia. Orphanet Journal of Rare Diseases, 9 (1) 36. doi: 10.1186/1750-1172-9-36
Pandit, Chetan, Valentin, Roumel, De Lima, Jonathan, Robinson, Paul, Fitzgerald, Dominic, Van Asperen, Peter, Baines, David, Cooper, Peter and Selvadurai, Hiran (2014). Effect of general anesthesia on pulmonary function and clinical status on children with cystic fibrosis. Paediatric Anaesthesia, 24 (2), 164-169. doi: 10.1111/pan.12256
Cystic fibrosis related diabetes: Potential pitfalls in the transition from paediatric to adult care
Middleton, Peter G., Matson, Angela G., Robinson, Paul D., Jane Holmes-Walker, D., Katz, Tamarah and Hameed, Shihab (2014). Cystic fibrosis related diabetes: Potential pitfalls in the transition from paediatric to adult care. Paediatric Respiratory Reviews, 15 (3), 281-284. doi: 10.1016/j.prrv.2014.05.003
Obesity and its impact on the respiratory system
Robinson, Paul D. (2014). Obesity and its impact on the respiratory system. Paediatric Respiratory Reviews, 15 (3), 219-226. doi: 10.1016/j.prrv.2014.06.003
Robinson, Paul D., Latzin, Philipp, Verbanck, Sylvia, Hall, Graham L., Horsley, Alexander, Gappa, Monika, Thamrin, Cindy, Arets, Hubertus G. M., Aurora, Paul, Fuchs, Susanne I., King, Gregory G., Lum, Sooky, Macleod, Kenneth, Paiva, Manuel, Pillow, Jane J., Ranganathan, Sarath, Ratjen, Felix, Singer, Florian, Sonnappa, Samatha, Stocks, Janet, Subbarao, Padmaja, Thompson, Bruce R. and Gustafsson, Per M. (2013). "Consensus statement for inert gas washout measurement using multiple- and single-breath tests." (vol 41, pg 507, 2013). European Respiratory Journal, 42 (5), 1432-1432. doi: 10.1183/09031936.50069712
Robinson, Paul D., Latzin, Philipp, Verbanck, Sylvia, Hall, Graham L., Horsley, Alexander, Gappa, Monika, Thamrin, Cindy, Arets, Hubertus G.M., Aurora, Paul, Fuchs, Susanne I., King, Gregory G., Lum, Sooky, Macleod, Kenneth, Paiva, Manuel, Pillow, Jane J., Ranganathan, Sarath, Ratjen, Felix, Singer, Florian, Sonnappa, Samatha, Stocks, Janet, Subbarao, Padmaja, Thompson, Bruce R. and Gustafsson, Per M. (2013). Erratum: Biomarker-guided clinical decisions: For patients, health economists or neither? (European Respiratory Journal (2013) 42 (895-897)). European Respiratory Journal, 42 (5). doi: 10.1183/09031936.50024813
Early intervention for newborns screened for cystic fibrosis
Beydon, Nicole and Robinson, Paul D. (2013). Early intervention for newborns screened for cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 188 (4), 409-410. doi: 10.1164/rccm.201306-1023ED
Newer treatments in the management of pediatric asthma
Robinson, Paul D. and Van Asperen, Peter (2013). Newer treatments in the management of pediatric asthma. Pediatric Drugs, 15 (4), 291-302. doi: 10.1007/s40272-013-0020-x
Age and height dependence of lung clearance index and functional residual capacity
Lum, Sooky, Stocks, Janet, Stanojevic, Sanja, Wade, Angie, Robinson, Paul, Gustafsson, Per, Brown, Meghan, Aurora, Paul, Subbarao, Padmaja, Hooe, Ah-Fong and Sonnappa, Samatha (2013). Age and height dependence of lung clearance index and functional residual capacity. European Respiratory Journal, 41 (6), 1371-1377. doi: 10.1183/09031936.00005512
Don't write off paediatric asthma action plans just yet
Marshall, Tracey, van Asperen, Peter, Selvadurai, Hiran and Robinson, Paul (2013). Don't write off paediatric asthma action plans just yet. Primary Care Respiratory Journal, 22 (2), 144-145. doi: 10.4104/pcrj.2013.00049
Paediatric lung transplant outcomes vary with Mycobacterium abscessus complex species
Robinson, Paul D., Harris, Kathryn A., Aurora, Paul, Hartley, John C., Tsang, Victor and Spencer, Helen (2013). Paediatric lung transplant outcomes vary with Mycobacterium abscessus complex species. European Respiratory Journal, 41 (5), 1230-1232. doi: 10.1183/09031936.00143512
Update in paediatric asthma management: Where is evidence challenging current practice?
Robinson, Paul D. and Van Asperen, Peter (2013). Update in paediatric asthma management: Where is evidence challenging current practice?. Journal of Paediatrics and Child Health, 49 (5), 346-352. doi: 10.1111/j.1440-1754.2010.01975.x
Abbreviated multi-breath washout for calculation of lung clearance index
Robinson, Paul D., Stocks, Janet, Aurora, Paul and Lum, Sooky (2013). Abbreviated multi-breath washout for calculation of lung clearance index. Pediatric Pulmonology, 48 (4), 336-343. doi: 10.1002/ppul.22618
Consensus statement for inert gas washout measurement using multiple- and singlebreath tests
Robinson, Paul D., Latzin, Philipp, Verbanck, Sylvia, Hall, Graham L., Horsley, Alexander, Gappa, Monika, Thamrin, Cindy, Arets, Hubertus G.M., Aurora, Paul, Fuchs, Susanne I., King, Gregory G., Lum, Sooky, Macleod, Kenneth, Paiva, Manuel, Pillow, Jane J., Ranganathan, Sarah, Ratjen, Felix, Singer, Florian, Sonnappa, Samatha, Stocks, Janet, Subbarao, Padmaja, Thompson, Bruce R. and Gustafsson, Per M. (2013). Consensus statement for inert gas washout measurement using multiple- and singlebreath tests. European Respiratory Journal, 41 (3), 507-522. doi: 10.1183/09031936.00069712
Wong, Rachel, Wong, Melanie, Robinson, Paul D. and Fitzgerald, Dominic A. (2013). Omalizumab in the management of steroid dependent Allergic Bronchopulmonary Aspergillosis (ABPA) complicating Cystic Fibrosis. Paediatric Respiratory Reviews, 14 (1), 22-24. doi: 10.1016/j.prrv.2012.11.004
Renal complications following lung and heart-lung transplantation
Robinson, Paul D., Shroff, Rukshana C. and Spencer, Helen (2013). Renal complications following lung and heart-lung transplantation. Pediatric Nephrology, 28 (3), 375-386. doi: 10.1007/s00467-012-2200-2
A realistic validation study of a new nitrogen multiple-breath washout system
Singer, Florian, Houltz, Birgitta, Latzin, Philipp, Robinson, Paul and Gustafsson, Per (2012). A realistic validation study of a new nitrogen multiple-breath washout system. PLoS ONE, 7 (4) e36083. doi: 10.1371/journal.pone.0036083
Sigurs, N., Aljassim, F., Kjellman, B., Robinson, P. D., Sigurbergsson, F., Bjarnason, R. and Gustafsson, P. M. (2011). Authors' response. Thorax, 66 (3). doi: 10.1136/thx.2010.153361
Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
Sigurs, Nele, Aljassim, Fatma, Kjellman, Bengt, Robinson, Paul D., Sigurbergsson, Fridrik, Bjarnason, Ragnar and Gustafsson, Per M. (2010). Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax, 65 (12), 1045-1052. doi: 10.1136/thx.2009.121582
Comparison of the utility of multiple breath inert gas washout parameters in cystic fibrosis
Robinson, P. D., Lindblad, A. and Gustafsson, P. M. (2010). Comparison of the utility of multiple breath inert gas washout parameters in cystic fibrosis. Thorax, 65 (7). doi: 10.1136/thx.2009.121590
Robinson, P. D., Latzin, P. and Gustafsson, P. M. (2010). Multiple-breath washout. Paediatric Lung Function (47), 87-104. doi: 10.1183/1025448x.00011909
Management of cystic fibrosis-related diabetes in children and adolescents
O'Riordan, Stephen M.P., Robinson, Paul D., Donaghue, Kim C. and Moran, Antoinette (2009). Management of cystic fibrosis-related diabetes in children and adolescents. Pediatric Diabetes, 10 (SUPPL. 12), 43-50. doi: 10.1111/j.1399-5448.2009.00587.x
Evidence-based management of paediatric primary spontaneous pneumothorax
Robinson, Paul D., Cooper, Peter and Ranganathan, Sarath C. (2009). Evidence-based management of paediatric primary spontaneous pneumothorax. Paediatric Respiratory Reviews, 10 (3), 110-117. doi: 10.1016/j.prrv.2008.12.003
A whisper from the silent lung zone
Aljassim, Fatma, Robinson, Paul D., Sigurs, Nele and Gustafsson, Per M. (2009). A whisper from the silent lung zone. Pediatric Pulmonology, 44 (8), 829-832. doi: 10.1002/ppul.20837
Robinson, Paul D., Cooper, Peter, Van Asperen, Peter, Fitzgerald, Dominic and Selvadurai, Hiran (2009). Using index of ventilation to assess response to treatment for acute pulmonary exacerbation in children with cystic fibrosis. Pediatric Pulmonology, 44 (8), 733-742. doi: 10.1002/ppul.20956
Robinson, Paul D. and Van Asperen, Peter (2009). Asthma in Childhood. Pediatric Clinics of North America, 56 (1), 191-226. doi: 10.1016/j.pcl.2008.10.008
Inert gas washout: Theoretical background and clinical utility in respiratory disease
Robinson, Paul D., Goldman, Michael D. and Gustafsson, Per M. (2009). Inert gas washout: Theoretical background and clinical utility in respiratory disease. Respiration, 78 (3), 339-355. doi: 10.1159/000225373
Are children just small adults? The differences between paediatric and adult sleep medicine
Robinson, P. D. and Waters, K. (2008). Are children just small adults? The differences between paediatric and adult sleep medicine. Internal Medicine Journal, 38 (9), 719-731. doi: 10.1111/j.1445-5994.2008.01719.x
Management of cystic fibrosis-related diabetes
O'riordan, Stephen M.P., Robinson, Paul D., Donaghue, Kim C. and Moran, Antoinette (2008). Management of cystic fibrosis-related diabetes. Pediatric Diabetes, 9 (4 PART 1), 338-344. doi: 10.1111/j.1399-5448.2008.00437.x
Tuberculosis in children: a tertiary centre perspective
Robinson, Paul D, Dalton, Dianne, Cripps, Terri, Wood, Nicholas J, Kesson, Alison M and Isaacs, David (2008). Tuberculosis in children: a tertiary centre perspective. The Medical journal of Australia, 188 (3), 190-1. doi: 10.5694/j.1326-5377.2008.tb01577.x
Congenital diaphragmatic hernia
Robinson, Paul D. and Fitzgerald, Dominic A. (2007). Congenital diaphragmatic hernia. Paediatric Respiratory Reviews, 8 (4), 323-335. doi: 10.1016/j.prrv.2007.08.004
Robinson, Paul D, Curtin, Julie A. and Van Asperen, Peter (2007). Blue blood. Journal of Paediatrics and Child Health, 43 (3), 184-185. doi: 10.1111/j.1440-1754.2007.01040.x
The re-emerging burden of rickets: A decade of experience from Sydney
Robinson, P. D., Högler, W., Craig, M. E., Verge, C. F., Walker, J. L., Piper, A. C., Woodhead, H. J., Cowell, C. T. and Ambler, G. R. (2006). The re-emerging burden of rickets: A decade of experience from Sydney. Archives of Disease in Childhood, 91 (7), 564-568. doi: 10.1136/adc.2004.069575
Robinson, Paul D., Lord, David J.E., Pozza, Luciano Dalla, Harvey, John G. and Van Asperen, Peter P. (2006). Complicated 'pneumonia'. Journal of Paediatrics and Child Health, 42 (1-2), 62-64. doi: 10.1111/j.1440-1754.2006.00775.x
Sena, Carla Rebeca Da Silva, Andrade, Ediane De Queiroz, Belinelo, Patricia De Gouveia, Murphy, Vanessa E., Robinson, Paul D., Gibson, Peter G., Sly, Peter D., Karmaus, Wilfried, Collison, Adam and Mattes, Joerg (2023). Lower tidal breathing lung function at 6 weeks of age, higher maternal BMI in pregnancy and larger sibship size are associated with viral bronchiolitis hospitalisations. Annual congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.OA1546
Lung function in infants whose mothers smoked during pregnancy
Andrade, De Queiroz E., Sena, Rebeca Da Silva C., Belinelo, De Gouveia P., Robinson, D. P., Blaxland, A., Sly, D. P., Murphy, E., Gibson, G. P., Collison, A. and Mattes, J. (2022). Lung function in infants whose mothers smoked during pregnancy. HOBOKEN: WILEY.
Sena, Carla Rebeca Da Silva, Andrade, Ediane De Queiroz, Belinelo, Patricia De Gouveia, Percival, Elizabeth, Prangemeier, Ben, O'Donoghue, Chris, Terry, Sandrine, Burke, Tanya, Gunning, William, Murphy, Vanessa E., Robinson, Paul D., Sly, Peter D., Gibson, Peter G., Collison, Adam and Mattes, Joerg (2021). Higher exhaled nitric oxide levels in infancy is associated with less bronchiolitis and fewer adverse respiratory outcomes in the first year of life. ERS International Congress, Virtual, 5-8 September 2021. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2021.PA3069
Rhinovirus bronchiolitis during infancy and later pre-school lung inhomogeneity
Sena, Carla Rebeca Da Silva, Shaar, Aida, Morten, Matthew, Meredith, Joseph, Kepreotes, Elizabeth, Murphy, Vanessa, Gibson, Peter, Sly, Peter, Whitehead, Bruce, Karmaus, Wilfried, Collison, Adam, Robinson, Paul D. and Mattes, Joerg (2021). Rhinovirus bronchiolitis during infancy and later pre-school lung inhomogeneity. ERS International Congress, Virtual, 5-8 September 2021. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2021.OA2571
Singh, J., Blaxland, A., Bailey, B., Fitzgerald, D. A., Selvadurai, H., Pandit, C., Towns, S. and Robinson, P. D. (2021). Multiple Breath Washout Experience in CFTR-Related Metabolic Syndrome at a Tertiary Cystic Fibrosis Centre. International Conference of the American-Thoracic-Society (ATS), Electr Network, May 14-19, 2021. NEW YORK: AMER THORACIC SOC.
Robinson, P. D., Peiris, S., Wong, A., Blaxland, A., King, G. and Thamrin, C. (2021). Phenotyping of Asthma Exacerbations Using Day-to-Day Variability in Oscillometry Measures in Children. International Conference of the American-Thoracic-Society (ATS), Electr Network, May 14-19, 2021. NEW YORK: AMER THORACIC SOC.
The Feasibility of Measuring Airway Derecruitment in Paediatric Patients with Asthma
Jeagal, E., Wong, A., Bayfield, K., Nilsen, K., Thamrin, C., King, G., Chapman, D. G. and Robinson, P. D. (2021). The Feasibility of Measuring Airway Derecruitment in Paediatric Patients with Asthma. International Conference of the American-Thoracic-Society (ATS), Electr Network, May 14-19, 2021. NEW YORK: AMER THORACIC SOC.
DOES TELEHEALTH ENHANCE OUT-OF-HOSPITAL PHYSIOTHERAPY SUPPORT FOR CHILDREN WITH CF?
Middleton, A., Hunt, S., Selvadurai, H., Robinson, P. D., Pandit, C. and Fitzgerald, D. (2019). DOES TELEHEALTH ENHANCE OUT-OF-HOSPITAL PHYSIOTHERAPY SUPPORT FOR CHILDREN WITH CF?. HOBOKEN: WILEY.
Lindblad, A., Robinson, P. D. and Gustafsson, P. (2019). LCI LEVELS MEASURED BY N-2 MULTIPLE BREATH WASHOUT ARE SIMILAR IN HEALTHY PRESCHOOLERS UP TO ADOLESCENCE BUT HIGH AND MARKEDLY VARIABLE IN HEALTHY INFANTS. HOBOKEN: WILEY.
MULTIPLE-BREATH WASHOUT RESEARCH TO CLINICAL PRACTICE
Robinson, Paul D. (2019). MULTIPLE-BREATH WASHOUT RESEARCH TO CLINICAL PRACTICE. HOBOKEN: WILEY.
OXYGEN EFFECT ON BREATHING PATTERN IN MULTIPLE BREATH WASHOUT DECREASES WITH AGE BEYOND INFANCY
Bayfield, K. J., Kennedy, B., Fitzgerald, D., Pandit, C., Selvadurai, H., Lindblad, A., Gustafsson, P. and Robinson, P. D. (2019). OXYGEN EFFECT ON BREATHING PATTERN IN MULTIPLE BREATH WASHOUT DECREASES WITH AGE BEYOND INFANCY. HOBOKEN: WILEY.
TRAPPED GAS ASSESSMENT DURING MULTIPLE BREATH WASHOUT IN CHILDREN WITH CYSTIC FIBROSIS
Hoeks, E. M., Bayfield, K. J., Wong, A., Kennedy, B. and Robinson, P. D. (2019). TRAPPED GAS ASSESSMENT DURING MULTIPLE BREATH WASHOUT IN CHILDREN WITH CYSTIC FIBROSIS. HOBOKEN: WILEY.
Late Breaking Abstract - Maternal asthma, weight gain in early life and infant lung function
Belinelo, Patricia De Gouveia, Jesson, Kathryn, Appenzeller, Rhea, Gorlanova, Olga, Collison, Adam, Oldmeadow, Christopher, Murphy, Vanessa E., Robinson, Paul D., Latzin, Philipp, Gibson, Peter, Frey, Urs and Mattes, Joerg (2019). Late Breaking Abstract - Maternal asthma, weight gain in early life and infant lung function. International Congress of the European-Respiratory-Society (ERS), Madrid Spain, Sep 28-Oct 02, 2019. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2019.OA4937
Hardaker, Kate M., Wong, Alexander, Jayasuriya, Geshani, Gabriel, Melissa Ann, Kennedy, Brendan, Keogh, Steven, Twist, Ida, Selvadurai, Hiran, Shaw, Peter J. and Robinson, Paul D. (2019). Longitudinal Utility of Peripheral Airway Function Tests in Pulmonary Graft Vs. Host Disease in Pediatric Bone Marrow Transplant Patients. Transplant and Cell Therapy Meeting / Combined Annual Meetings of the American-Society-for-Blood-and-Marrow-Transplantation (ASBMT) and the Center-for-International-Blood-and-Marrow-Transplant-Research (CIBMTR), Houston Tx, Feb 13-24, 2019. NEW YORK: ELSEVIER SCIENCE INC.
SF(6)And N2MBW in a Healthy Infant, Preschool and School-Aged Control Population
Robinson, P. D., Lindblad, A., Kadar, L., Kjellberg, S., Rosberg, M. and Gustafsson, P. (2019). SF(6)And N2MBW in a Healthy Infant, Preschool and School-Aged Control Population. International Conference of the American-Thoracic-Society, Dallas Tx, May 17-22, 2019. NEW YORK: AMER THORACIC SOC.
Jayasuriya, Rathnini, Walker, Terri, Sa, Rui, Robinson, Paul, King, Greg, Prisk, Kim, Theilman, Rebecca, Coward, Emma, Kennedy, Brendan and Selvadurai, Hiran (2018). Feasibility of specific ventilation imaging using oxygen enhanced magnetic resonance imaging (OEMRI) in adolescents. 28th International Congress of the European-Respiratory-Society (ERS), Paris France, Sep 15-19, 2018. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2018.PA563
Belinelo, Patricia de Gouveia, Nielsen, Aleisha, Goddard, Bernadette, Collison, Adam M., Robinson, Paul D., Whitehead, Bruce, Hilton, Jodi, Gulliver, Tanya, Roddick, Laurence, Platt, Lauren, Pearce, Kasey and Mattes, Joerg (2018). Nitrogen (N2) multiple breath washout: Assessment of ventilation inhomogeneity in severe paediatric asthma. 28th International Congress of the European-Respiratory-Society (ERS), Paris France, Sep 15-19, 2018. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2018.PA1316
IMPROVING MULTIPLE BREATH WASHOUT TRAINING: EVALUATION OF E-LEARNING MODULES
Au, J. W., Isaac, S. M., Jensen, R., Robinson, P. D., Saunders, C., Stanojevic, S. and Ratjen, F. (2018). IMPROVING MULTIPLE BREATH WASHOUT TRAINING: EVALUATION OF E-LEARNING MODULES. HOBOKEN: WILEY.
Mamlouk, Mariam, Young, Paul, Traini, Daniela, Ghadiri, Maliheh, Ong, Hui Xin and Robinson, Paul (2017). DEVELOPMENT OF AN IN-VITRO MUCUS MODEL TO EVALUATE THE EFFECT OF MAGNESIUM ON CURRENT MUCOLYTIC THERAPIES FOR CYSTIC FIBROSIS TREATMENT. HOBOKEN: WILEY.
Htun, Christopher, Schoeffel, Robin, Lahzami, Samir, Philips, Craig, Pope, Alun, Robinson, Paul, Greenwood, Matthew and King, Gregory (2017). CHANGES IN PERIPHERAL AIRWAY FUNCTION AT 12 MONTHS POST ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION (ALLO-HSCT). HOBOKEN: WILEY.
Htun, Christopher, Schoeffel, Robin, Lahzami, Samir, Philips, Craig, Pope, Alun, Robinson, Paul, Greenwood, Matthew and King, Gregory (2017). CHANGES IN PERIPHERAL AIRWAY FUNCTION AT 12 MONTHS POST ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION (ALLO-HSCT). HOBOKEN: WILEY.
Lin, Beryl, Kennedy, Brendan, McBride, Jamie, Dalla-Pozza, Luciano, Trahair, Toby, McCowage, Geoff, Coward, Emma, Plush, Leanne, Robinson, Paul, Hardaker, Kate, Widger, John, Jaffe, Adam and Selvadurai, Hiran (2017). LONG-TERM MORBIDITY OF RESPIRATORY VIRAL INFECTIONS DURING CHEMOTHERAPY IN CHILDREN WITH LEUKAEMIA - PILOT STUDY. HOBOKEN: WILEY.
Asthma Control During Pregnancy, 17Q21 Variants and Childhood-Onset Asthma
Morten, Matthew, Collison, Adam, Murphy, Vanessa, Barker, Daniel, Meredith, Joseph, Powell, Heather, Robinson, Paul, Sly, Peter, Gibson, Peter and Mattes, Joerg (2017). Asthma Control During Pregnancy, 17Q21 Variants and Childhood-Onset Asthma. The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Canberra, Australia, 24–28 March 2017. Richmond, VIC Australia: Wiley.
Lin, B., Kennedy, B., McBride, J., Dalla-Pozza, L., Trahair, T., McCowage, G., Coward, E., Plush, L., Robinson, P. D., Hardaker, K., Widger, J., Jaffe, A. and Selvadurai, H. (2017). Long-Term Morbidity Of Respiratory Viral Infections During Chemotherapy In Children With Leukaemia: A Historical Prospective Cohort Study. International Conference of the American-Thoracic-Society (ATS), Washington Dc, May 19-24, 2017. NEW YORK: AMER THORACIC SOC.
Pham, Thuy T., Nguyen, Diep N., Dutkiewicz, Eryk, McEwan, Alistair L., Thamrin, Cindy, Robinson, Paul D. and Leong, Philip H. W. (2016). Feature engineering and supervised learning classifiers for respiratory artefact removal in lung function tests. 59th Annual IEEE Global Communications Conference (IEEE GLOBECOM 2016), Washington, DC, United States, 4-8 December 2016. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers Inc.. doi: 10.1109/GLOCOM.2016.7841839
Peripheral Airway Dysfunction In The Dunedin Cohort At Age 38 Years
Robinson, P. D., King, G. G., Sears, M. R., Hong, C. Yen and Hancox, R. (2016). Peripheral Airway Dysfunction In The Dunedin Cohort At Age 38 Years. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca, May 13-18, 2016. NEW YORK: AMER THORACIC SOC.
Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations
Sonneveld, Nicole, Stanojevic, Sanja, Amin, Reshma, Aurora, Paul, Davies, Jane, Elborn, J. Stuart, Horsley, Alex, Latzin, Philipp, O'Neill, Katherine, Robinson, Paul, Scrase, Emma, Selvadurai, Hiran, Subbarao, Padmaja, Welsh, Liam, Yammine, Sophie and Ratjen, Felix (2015). Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations. European Respiratory Society. doi: 10.1183/09031936.00211914
FEV1/FVC ratio does not reflect peripheral airway ageing in an elderly reference population
Kjellberg, Sanna, Houltz, Birgitta, Robinson, Paul and Gustafsson, Per (2015). FEV1/FVC ratio does not reflect peripheral airway ageing in an elderly reference population. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2015.PA4616
Strom, Maria, Houltz, Birgitta, Robinson, Paul D., Lindblad, Anders, Green, Kent, Nielsen, Kim G., Singer, Florian and Gustafsson, Per (2015). Lung clearance index (LCI) based on four different alveolar N-2 estimates in a large reference population aged 6-86 years. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2015.PA2286
Peripheral airway abnormalities are common in children post bone marrow transplantation
Jayasuriya, Geshani, King, Greg, Selvadurai, Hiran, Gabriel, Melissa, Gustaffson, Per, Hardaker, Kate, Kennedy, Brendan, Keogh, Steven, O'Brien, Ida, Shaw, Peter and Robinson, Paul (2015). Peripheral airway abnormalities are common in children post bone marrow transplantation. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2015.PA1269
Gonzalez, Miguel Garcia, McKay, Karen, Cooper, Peter, Selvadurai, Hiran, Fitzgerald, Dominic and Robinson, Paul D. (2015). Prolonged oral corticosteroid therapy in allergic bronchopulmonary aspergillosis (ABPA) treatment does not increase pseudomonas aeruginosa risk. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2015.PA1300
Hardaker, Kate, Jayasuriya, Geshani, Gustafsson, Per, Cooper, Peter, Fitzgerald, Dominic, Selvadurai, Hiran and Robinson, Paul (2015). Time between multiple breath nitrogen washout (MBNW) tests: Is duration of washout enough across childhood?. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2015.PA4147
Hardaker, K. M., Gustafsson, P., Jayasuriya, G., Cooper, P., Fitzgerald, D., Selvadurai, H. and Robinson, P. D. (2015). Feasibility Of Concentration Normalized Phase Iii (sniii) Analysis Across The Paediatric Age Range Using Updated Acceptability Criteria. International Conference of the American-Thoracic-Society (ATS), Denver Co, May 15-20, 2015. NEW YORK: AMER THORACIC SOC.
Jetmalani, K., Robinson, P. D., King, G., Kjellberg, S. and Gustafsson, P. (2015). Inter- And Intra-Regional Ventilation Heterogeneity Pre And Post Bronchodilator Administration In COPD. International Conference of the American-Thoracic-Society (ATS), Denver Co, May 15-20, 2015. NEW YORK: AMER THORACIC SOC.
Middleton, A., Robinson, P. D., Mckay, K. and Selvadurai, H. (2013). PILOT STUDY OF INHALED DRY POWDER MANNITOL IN YOUNG CF PEOPLE HOSPITALIZED FOR ACUTE PULMONARY EXACERBATION. HOBOKEN: WILEY-BLACKWELL.
Automated Quality Control Of Forced Oscillation Measurements Using A Complete Breath Algorithm
Thamrin, C., Brown, N. J., Jee, A., Gutzler, T., Timmins, S. C., Salome, C. M., King, G. and Robinson, P. D. (2013). Automated Quality Control Of Forced Oscillation Measurements Using A Complete Breath Algorithm. NEW YORK: AMER THORACIC SOC.
Rosenfeld, M., Allen, J., Arets, B.H.G.M., Aurora, P., Beydon, N., Calogero, C., Castile, R.G., Davis, S.D., Fuchs, S., Gappa, M., Gustaffson, P.M., Hall, G.L., Jones, M.H., Kirkby, J.C., Kraemer, R., Lombardi, E., Lum, S., Mayer, O.H., Merkus, P., Nielsen, K.G., Oliver, C., Oostveen, E., Ranganathan, S., Ren, C.L., Robinson, P.D., Seddon, P.C., Sly, P.D., Sockrider, M.M., Sonnappa, S. ... Vilozni, D. (2013). Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age. -, -, -. New York, NY, U.S.A.: American Thoracic Society. doi: 10.1513/AnnalsATS.201301-017ST
Forced Oscillation Technique at Ages 3, 5, and 8 Years in a High Risk Asthma Birth Cohort
Robinson, P. D., King, G. G., Brown, N. and Marks, G. (2009). Forced Oscillation Technique at Ages 3, 5, and 8 Years in a High Risk Asthma Birth Cohort. NEW YORK: AMER THORACIC SOC.
Robinson, P. D., Wernstedt, P., Brune, M. and Gustafsson, P. M. (2009). SDCDI, an Additional Index to Sacin To Assess Diffusion-Convection Dependent Inhomogeneity in Multiple Breath Inert Gas Washout Analysis. NEW YORK: AMER THORACIC SOC.
(2023–2028) Vertex Pharmaceuticals Inc
(2023–2027) University of Melbourne
MBW Training and LCI Overread Services in Support of VX20-455-112
(2023–2026) Vertex Pharmaceuticals Inc
MBW Training and LCI Overread Services in Support of VX21-121-105
(2023–2026) Vertex Pharmaceuticals Inc
ARCT-032-01: Phase 1/1b study of ARCT-032 in Healthy Adult Subjects and Adults with Cystic Fibrosis
(2023–2024) Arcturus Therapeutics Inc
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Remote monitoring of Paediatric Asthma to Improve Asthma Diagnosis and Control
Childhood asthma mortality remains substantial, and rates of hospitalisation are increasing globally in young children. This is driven by poor asthma control (which affects 50% of asthmatics) and ongoing exacerbations (which affects 25%). Of the 40,000 admissions each year, 80% are preventable! Current symptom-based management approaches fail – limited by poor perception/reporting by children and parents - and conventional spirometry/peak flow is insensitive or too challenging for this setting. In addition, the preschool age range is a critical period in asthma pathogenesis: symptoms emerge, airway structure changes, and a window for intervention exists before permanent lung function deficit is established by early school age. Preschool symptom-based diagnostic and/or predictive tools (for later asthma) perform poorly and ignore lung function due to spirometry’s limitations. Improved ability to differentiate early asthma phenotypes is a priority of international societies.
This research program consists of a series of projects to analyse existing, and collect new, data to define the clinical utility of a unique remote home-based monitoring strategy focused on the day-to-day variability of a novel and sensitive lung function test. Studies will investigate its ability to correctly identify evolving asthma, detect loss of asthma control and provide an early signal of an impending asthma exacerbation to improve long term asthma outcomes.
Improving detection of Pulmonary Graft-vs-Host Disease to facilitate earlier intervention
Chronic Graft-vs-Host Disease affects 60% of Haematopoeitic Stem Cell Transplant (HSCT) survivors by 6 years after their transplant, affecting multiple organs including skin, liver, gastrointestinal tract and lungs. Gold standard for pulmonary GVHD diagnosis is abnormal spirometry and subsequent CT-based imaging. Pulmonary GVHD is estimated to affect 20% of all subjects post HSCT yet this incidence is a gross underestimate due to the insensitivity of spirometry to detect peripheral lung changes. This leads to late diagnosis, poor response to treatment, and poor prognosis (5-year mortality is 85%). Better tools to detect and monitor pulmonary GVHD are urgently required.
This research program builds on previous work highlighting the potential utility of novel peripheral airway function test in this setting. It will analyse both local data and pooled international data across 12 international centres (including both paediatric and adult data) to define the utility of these tools to provide an earlier diagnosis of pulmonary GVHD to facilitate earlier invention and improve outcomes. It will also explore novel applications of these tests to enhance detection further in the initial period post HSCT to predict and detect those at risk.