The University of Queensland

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

Smith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671

Heparan sulfate proteoglycans: key mediators of stem cell function

Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor and Cool, Simon M. (2020). Heparan sulfate proteoglycans: key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8 581213, 581213. doi: 10.3389/fcell.2020.581213

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056

Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells

Huang, Mia L., Smith, Raymond A. A., Trieger, Greg W. and Godula, Kamil (2014). Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. Journal of the American Chemical Society, 136 (30), 10565-10568. doi: 10.1021/ja505012a

Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics

Huang, Mia L., Smith, Raymond A. A., Trieger, Greg W. and Godula, Kamil (2016). Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics. Macro-glycoligands: methods and protocols. (pp. 207-224) edited by Xue-Long Sun. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-3130-9_17

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2

Shaffer, Karl J., Smith, Raymond A. A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F. R., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2024). Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2. Carbohydrate Polymers, 333 121979, 121979. doi: 10.1016/j.carbpol.2024.121979

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

Smith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671

Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis

Luo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na and Cool, Simon M. (2023). Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports, 13 (1) 11774, 1-15. doi: 10.1038/s41598-023-38818-y

Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications

Guo, Jiayi, Park, Eun Ju, Teo, Yew Chin, Abbas, Asyraf, Goh, Denise, Smith, Raymond Alexander Alfred, Nie, Yuntong, Nguyen, Hang T. L., Yeong, Joe Poh Sheng, Cool, Simon, Haruyuki, Makio and Teo, Peili (2023). Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications. Polymer Chemistry, 14 (15), 1743-1751. doi: 10.1039/d2py01545e

Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering

Teo, Yew Chin, Park, Eun Ju, Guo, Jiayi, Abbas, Asyraf, Smith, Raymond Alexander Alfred, Goh, Denise, Yeong, Joe Poh Sheng, Cool, Simon and Teo, Peili (2022). Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering. ACS Applied Bio Materials, 5 (10), 4770-4778. doi: 10.1021/acsabm.2c00455

Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion

Srinivasan, Akshaya, Sathiyanathan, Padmapriya, Yin, Lu, Liu, Tong Ming, Lam, Alan, Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Loh, Han Ping, Zhang, Ying, Ling, Ling, Ng, Say Kong, Yang, Yuan Sheng, Lezhava, Alexander, Hui, James, Oh, Steve and Cool, Simon M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24 (5), 456-472. doi: 10.1016/j.jcyt.2021.11.009

Variability in the composition of porcine mucosal heparan sulfates

Sargison, Liam, Smith, Raymond A A, Carnachan, Susan M, Daines, Alison M, Brackovic, Amira, Kidgell, Joel T, Nurcombe, Victor, Cool, Simon M, Sims, Ian M and Hinkley, Simon F R (2022). Variability in the composition of porcine mucosal heparan sulfates. Carbohydrate Polymers, 282 119081, 119081. doi: 10.1016/j.carbpol.2021.119081

Application of a BMP2-binding heparan sulphate to promote periodontal regeneration

Le, B. Q., Too, J. H., Tan, T. C., Smith, R. A. A., Nurcombe, , Cool, S. M. and Yu, N. (2021). Application of a BMP2-binding heparan sulphate to promote periodontal regeneration. European Cells and Materials, 42, 139-153. doi: 10.22203/eCM.v042a10

Heparan sulfate proteoglycans: key mediators of stem cell function

Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor and Cool, Simon M. (2020). Heparan sulfate proteoglycans: key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8 581213, 581213. doi: 10.3389/fcell.2020.581213

Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia

Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A. A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H. and Nurcombe, Victor (2020). Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia. Stroke, 51 (9), 2844-2853. doi: 10.1161/STROKEAHA.119.025304

A synthetic heparan sulphate mimetic for enhancing BMP-2-mediated osteogenesis and bone regeneration

Smith, R.A., Lu, X., Tan, T., Luo, X., Le, B.Q., Zubkova, O.V., Cool, S. and Nurcombe, V. (2020). A synthetic heparan sulphate mimetic for enhancing BMP-2-mediated osteogenesis and bone regeneration. Cytotherapy, 22 (5), S32-S32. doi: 10.1016/j.jcyt.2020.03.017

Enhancing the efficacy of stem cell therapy with glycosaminoglycans

Ling, Ling, Ren, Xiafei, Cao, Xue, Hassan, Afizah Binte Mohd, Mah, Sophia, Sathiyanathan, Padmapriya, Smith, Raymond A. A., Tan, Clarissa L. L., Eio, Michelle, Samsonraj, Rebekah M., Van Wijnen, Andre J., Raghunath, Michael, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2020). Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports, 14 (1), 105-121. doi: 10.1016/j.stemcr.2019.12.003

Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective

Nurcombe, Victor, Ling, Ling, Hondermarck, Hubert, Cool, Simon M. and Smith, Raymond A. A. (2019). Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective. Proteomics, 19 (21-22) 1800466, 1800466. doi: 10.1002/pmic.201800466

A heparan sulfate device for the regeneration of osteochondral defects

Lee, Jonathan H., Luo, Xiaoman, Ren, Xiafei, Tan, Tuan Chun, Smith, Raymond A.A., Swaminathan, Kunchithapadam, Sekar, Sakthivel, Bhakoo, Kishore, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2019). A heparan sulfate device for the regeneration of osteochondral defects. Tissue Engineering - Part A, 25 (5-6), 352-363. doi: 10.1089/ten.tea.2018.0171

Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy

Zubkova, Olga V., Ahmed, Yassir A., Guimond, Scott E., Noble, Sophia-Louise, Miller, John Holmes, Smith, Raymond Alexander Alfred, Nurcombe, Victor, Tyler, Peter C., Weissmann, Marina, Vlodavsky, Israel and Turnbull, Jeremy E. (2018). Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy. ACS Chemical Biology, 13 (12), 3236-3242. doi: 10.1021/acschembio.8b00909

Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate

Poon, Selina, Lu, Xiaohua, Smith, Raymond A. A., Ho, Pei, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2018). Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate. Angiogenesis, 21 (4), 777-791. doi: 10.1007/s10456-018-9622-9

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056

Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation

Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor and Cool, Simon M. (2018). Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation. Tissue Engineering - Part A, 24 (9-10), 729-739. doi: 10.1089/ten.tea.2017.0263

Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state

Huang, Mia L., Michalak, Austen L., Fisher, Christopher J., Christy, Mitchell, Smith, Raymond A. A. and Godula, Kamil (2018). Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells, 36 (1), 45-54. doi: 10.1002/stem.2714

Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications

Ayerst, Bethanie I., Smith, Raymond A.A., Nurcombe, Victor, Day, Anthony J., Merry, Catherine L.R. and Cool, Simon M. (2017). Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications. Tissue Engineering - Part A, 23 (7-8), 275-292. doi: 10.1089/ten.tea.2016.0364

Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment

Carnachan, Susan M., Bell, Tracey J., Sims, Ian M., Smith, Raymond A.A., Nurcombe, Victor, Cool, Simon M. and Hinkley, Simon F.R. (2016). Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment. Carbohydrate Polymers, 152, 592-597. doi: 10.1016/j.carbpol.2016.07.024

Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling

Lee, Jonathan, Wee, Sheena, Gunaratne, Jayantha, Chua, R. J. E., Smith, Raymond A. A., Ling, Ling, Fernig, David G., Swaminathan, Kunchithapadam, Nurcombe, Victor and Cool, Simon M. (2015). Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling. Glycobiology, 25 (12), 1491-1504. doi: 10.1093/glycob/cwv064

Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes

Holley, Rebecca J., Smith, Raymond A., van de Westerlo, Els M. A., Pickford, Claire E., Merry, C. L. R. and van Kuppevelt, Toin H. (2015). Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes. Glycosaminoglycans: Chemistry and Biology, 1229, 239-251. doi: 10.1007/978-1-4939-1714-3_21

Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells

Huang, Mia L., Smith, Raymond A. A., Trieger, Greg W. and Godula, Kamil (2014). Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. Journal of the American Chemical Society, 136 (30), 10565-10568. doi: 10.1021/ja505012a

Glycosaminoglycans as regulators of stem cell differentiation

Smith, Raymond A. A., Meade, Kate, Pickford, Claire E., Holley, Rebecca J. and Merry, Catherine L. R. (2011). Glycosaminoglycans as regulators of stem cell differentiation. Biochemical Society Transactions, 39 (1), 383-387. doi: 10.1042/bst0390383

Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells

Ling, L., Ren, X., Hassan, A. Binte Mohd, Mah, S., Smith, R. A., Tan, C., van Wijnen, A., Raghunath, M., Nurcombe, V., Hui, J. and Cool, S. (2019). Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells. ISCT 2019, Melbourne, VIC, Australia, 29 May - 1 June 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2019.03.463

Harnessing glycocalyx interactions to modulate differentiation and development

Huang, Mia L., Michalak, Austen L., Tota, Ember M., Smith, Raymond Alexander, Trieger, Greg W. and Godula, Kamil (2018). Harnessing glycocalyx interactions to modulate differentiation and development. Experimental Biology 2018 Meeting, San Diego, CA United States, 21-25 April 2018. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2018.32.1_supplement.673.16

Glycocalyx based strategies to modulate embryonic stem cell fates

Huang, Mia, Godula, Kamil, Smith, Raymond, Christy, Mitchell, Fisher, Christopher and Michalak, Austen (2016). Glycocalyx based strategies to modulate embryonic stem cell fates. Washington, DC, United States: American Chemical Society.

Glycocalyx remodeling with synthetic proteoglycan mimetics promotes neural specification in embryonic stem cells

Godula, Kamil, Huang, Mia, Smith, Raymond and Trieger, Greg (2014). Glycocalyx remodeling with synthetic proteoglycan mimetics promotes neural specification in embryonic stem cells. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, United States, 16-19 November 2014. Cary, NC, United States: Oxford University Press.