Dr Ayaho Yamamoto

Postdoctoral Research Fellow

Child Health Research Centre
Faculty of Medicine

Overview

Dr. Ayaho Yamamoto is a research fellow in the field of Biomedical Science. Her research focuses on understanding the mechanistic links between environmental exposures and adverse respiratory outcomes. In particular, focuses on the cellular responses following air pollution exposure and/or viral infection on human respiratory epithelium, and the age differences in immune defence mechanisms. Investigate on early intervention strategies with dietary antioxidants to improve respiratory health and reduce the risk of long-term chronic diseases.

Dr. Yamamoto has a Bachelor of Science in Environmental Health and Public Health; her research focused on childhood asthma. She has a Master of Science in Biomedical Science and Pharmacology; the research focus was to understand the mechanisms and to test new drugs for osteoporosis and chondrosarcomas metastasis. She has worked in a Uni-based start-up company for drug development.

Research Interests

  • Environmental exposure and respiratory epithelium
  • Oxidative stress and antioxidants
  • Respiratory viral infection
  • Mitochondria

Qualifications

  • Doctor of Philosophy of Biomedical Sciences, The University of Queensland

Publications

View all Publications

Available Projects

  • In our previous studies, we found that some individual humans are more susceptible to air pollution exposure than others. However, it is unclear that what factors impact on this phenomenon. In this project, we will combine clinical data with biological specimens to investigate the health risk from pollution exposure on human subjects.

    Clinical aspect: conduct surveys with patients or volunteers.

    Laboratory: work with respiratory cells collected from the human subjects to determine the factors impact on individual susceptibility to adverse environmental exposures and how this translates into poor respiratory health.

    Outcomes: identify factors impact on poor respiratory health from surveys and cellular experiments.

    You will have the opportunity to gain both clinical and lab experience.

    Welcome to both Honours and HDR students.

    Last update: 2023

  • Exposure to poor air quality is associated with adverse respiratory health. Environmentally persistent free radicals (EPFRs) are combustion products present in substantial numbers on atmospheric particulate matter that have half-lives of days to years. EPFRs can induce oxidative stress and have long lasting effect on biological systems, however, the mechanistic links between EPFR exposure and respiratory diseases are still unclear.

    This project aims to develop a chronic EPFR exposure model using VITROCELL® Cloud 12 system and use this model to examine the innate immune and cellular responses, as well as mitochondrial function in fully differentiated respiratory epithelium culture at air-liquid interface.

    This project would suit a student with a background in cell and molecular biology. Knowledge of or experience in basic laboratory techniques such as cell culture, immunofluorescence and western blotting would be helpful.

    Welcome to both Honours and HDR students.

    Last update: 2023

View all Available Projects

Publications

Journal Article

Conference Publication

  • Yamamoto, A., Sly, P. D., Khachatryan, L., Yeo, A. J., Cormier, S. A. and Fantino, E. (2023). Environmentally persistent free radicals modify oxidative stress related gene expression in well-differentiated human nasal epithelium. American Thoracic Society 2023 International Conference, Washington, DC USA, 19-24 May 2023. Washington, DC USA: American Thoracic Society. doi: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5682

  • Yamamoto, A., Yeo, A. J., Sly, P. D., Cormier, S. A., Lomnicki, S., Khachatryan, L. and Fantino, E. (2021). The effect of combustion generated environmentally persistent free radicals on well-differentiated human airway epithelial cells. American Thoracic Society 2021 International Conference, Virtual, 14-19 May 2021. New York, NY USA: American Thoracic Society. doi: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4289

  • Yamamoto, A., Yeo, A. J., Deane, A., Sly, P. D. and Fantino, E. (2020). The effect of oxidative stress on human airway epithelial cells. International Conference of the American-Thoracic-Society, Electr Network, 2020. New York, NY, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2304

  • Yamamoto, A., Henningham, A., Sly, P. and Fantino, E. (2019). Cellular senscence in differentiated human primary nasal epithelial cells. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492

Other Outputs

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • In our previous studies, we found that some individual humans are more susceptible to air pollution exposure than others. However, it is unclear that what factors impact on this phenomenon. In this project, we will combine clinical data with biological specimens to investigate the health risk from pollution exposure on human subjects.

    Clinical aspect: conduct surveys with patients or volunteers.

    Laboratory: work with respiratory cells collected from the human subjects to determine the factors impact on individual susceptibility to adverse environmental exposures and how this translates into poor respiratory health.

    Outcomes: identify factors impact on poor respiratory health from surveys and cellular experiments.

    You will have the opportunity to gain both clinical and lab experience.

    Welcome to both Honours and HDR students.

    Last update: 2023

  • Exposure to poor air quality is associated with adverse respiratory health. Environmentally persistent free radicals (EPFRs) are combustion products present in substantial numbers on atmospheric particulate matter that have half-lives of days to years. EPFRs can induce oxidative stress and have long lasting effect on biological systems, however, the mechanistic links between EPFR exposure and respiratory diseases are still unclear.

    This project aims to develop a chronic EPFR exposure model using VITROCELL® Cloud 12 system and use this model to examine the innate immune and cellular responses, as well as mitochondrial function in fully differentiated respiratory epithelium culture at air-liquid interface.

    This project would suit a student with a background in cell and molecular biology. Knowledge of or experience in basic laboratory techniques such as cell culture, immunofluorescence and western blotting would be helpful.

    Welcome to both Honours and HDR students.

    Last update: 2023