Associate Professor Joy Wolfram

Principal Research Fellow

School of Chemical Engineering
Faculty of Engineering, Architecture and Information Technology

Group Leader

Australian Institute for Bioengineering and Nanotechnology

Overview

Associate Professor Joy Wolfram leads a nanomedicine and extracellular vesicle research program with the goal of developing innovative approaches that bring the next generation of treatments and diagnostics directly to the clinic. She has joint appointments in the School of Chemical Engineering and the Australian Institute for Bioengineering and Nanotechnology at The University of Queensland, Australia (#36 in Best Global Universities, U.S. News & World Report).

MISSION

1) Develop a new paradigm of therapeutics (using nanotechnology and cell products) to treat life-threatening diseases that are major causes of death globally, including cardiovascular disease, kidney disease, and breast cancer

2) Save lives by manufacturing at scale - Deliver national manufacturing innovation and a skilled workforce

3) Work with a multidisciplinary team and industry partners to position Australia as a global leader in extracellular vesicle medicine

Extracellular vesicles are small biomolecular packages (released locally and systemically) that are crucial for intercellular communication. Extracellular vesicles have promising potential to be leveraged and engineered to provide a paradigm shift in cell-free therapy. Unresolved challenges in the field include scalable manufacturing, understanding therapeutic/pathological mechanisms, and capacity to use extracellular vesicles for drug delivery. The Wolfram Laboratory is leveraging innovations in manufacturing, biological mechanisms, and drug loading of extracellular vesicles to develop therapeutics to alter the trajectory of disease, improve patient outcomes, and prolong healthy lifespan.

FOCUS AREAS

1) Developing improved methods for extracellular vesicle isolation from human biofluids

2) Designing hybrid drug delivery systems with extracellular vesicle and synthetic components for a ‘best-of-both-worlds’ approach to treat cardiovascular disease and chronic kidney disease

3) Understanding the role of extracellular vesicles in cancer immunoevasion and metastasis

The research program has resulted in more than 80 publications in journals, such as, Nature Nanotechnology, Materials Today, and Nature Reviews Materials. These publications have been cited 13,600 times (Google Scholar). The Wolfram Laboratory has collaborated with 160 universities and industry partners across 45 countries (Scopus). The research program has also been featured in more than 100 presentations at scientific meetings, including 78 invited talks and eight international keynote talks.

Associate Professor Wolfram is actively involved in community outreach and education, including her previous roles as the Chair of an education and outreach working group of the National Institutes of Health in the United States and the Associate Program Director of the PhD Program in Regenerative Sciences at Mayo Clinic (Best Hospital in the World, Newsweek). As a TED speaker, she strives to bring science to a wider audience.

She has received more than 30 awards from eight countries, including the 2016 Amgen Scholars Ten to Watch List (best and brightest up-and-comers in science and medicine across 42 countries), the 2019 Forbes 30 under 30 list in Health Care in the United States/Canada, the 2019 shortlist for the Nature Research Award for Inspiring Science (one of ten worldwide), and the 2021 Finnish Expatriate of the Year (past recipients include Nobel Memorial Prize winners, Millennium Technology Prize winners, and Formula 1 drivers). She is in the top 1% of researchers worldwide in the categories of ‘Biology & Biochemistry’ and ‘Pharmacology & Toxicology' (Essential Science Indicators, 2023).

Qualifications

  • Member, Global Young Academy, Global Young Academy
  • Doctor of Philosophy, University of the Chinese Academy of Science
  • Masters (Coursework), University of Helsinki*
  • Bachelor, University of Helsinki*

Publications

  • Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrugger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, My G., Mohanty, Sujata, Moller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco ... Allenby, Mark (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper. Journal of Extracellular Vesicles, 13 (2) e12404. doi: 10.1002/jev2.12404

  • Pendiuk Goncalves, Jenifer, Cruz Villarreal, Jorvani, Walker, Sierra A., Tan, Xuan Ning Sharon, Borges, Chad and Wolfram, Joy (2024). High-throughput analysis of glycan sorting into extracellular vesicles. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1871 (2) 119641, 119641. doi: 10.1016/j.bbamcr.2023.119641

  • Ghebosu, Raluca E., Pendiuk Goncalves, Jenifer and Wolfram, Joy (2023). Extracellular Vesicle and Lipoprotein Interactions. Nano Letters, 24 (1), 1-8. doi: 10.1021/acs.nanolett.3c03579

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Available Projects

  • Please contact the Wolfram Laboratory if you are interested in PhD projects on:

    - Deveoping extracellular vesicle therapeutics for cardiovascular inflammation

    - Understanding the contribution of extracellular vesicles in breast cancer immunoevasion

View all Available Projects

Publications

Book Chapter

  • Borsoi, Carlotta, Wolfram, Joy and Ferrari, Mauro (2017). Nanomedicine activities in the United States and worldwide. Nanoscience and nanotechnology for human health. (pp. 21-50) edited by Bert Müller and Marcel Van de Voorde. Weinheim, Germany: Wiley-VCH . doi: 10.1002/9783527692057.ch3

  • Suri, Krishna, Wolfram, Joy, Shen, Haifa and Ferrari, Mauro (2015). Advances in Nanotechnology-Based Drug Delivery Platforms and Novel Drug Delivery Systems. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. (pp. 41-58) Elsevier Inc.. doi: 10.1016/B978-0-12-416603-5.00003-1

Journal Article

  • Welsh, Joshua A., Goberdhan, Deborah C. I., O'Driscoll, Lorraine, Buzas, Edit I., Blenkiron, Cherie, Bussolati, Benedetta, Cai, Houjian, Di Vizio, Dolores, Driedonks, Tom A. P., Erdbrugger, Uta, Falcon-Perez, Juan M., Fu, Qing-Ling, Hill, Andrew F., Lenassi, Metka, Lim, Sai Kiang, Mahoney, My G., Mohanty, Sujata, Moller, Andreas, Nieuwland, Rienk, Ochiya, Takahiro, Sahoo, Susmita, Torrecilhas, Ana C., Zheng, Lei, Zijlstra, Andries, Abuelreich, Sarah, Bagabas, Reem, Bergese, Paolo, Bridges, Esther M., Brucale, Marco ... Allenby, Mark (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches: Position paper. Journal of Extracellular Vesicles, 13 (2) e12404. doi: 10.1002/jev2.12404

  • Pendiuk Goncalves, Jenifer, Cruz Villarreal, Jorvani, Walker, Sierra A., Tan, Xuan Ning Sharon, Borges, Chad and Wolfram, Joy (2024). High-throughput analysis of glycan sorting into extracellular vesicles. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1871 (2) 119641, 119641. doi: 10.1016/j.bbamcr.2023.119641

  • Ghebosu, Raluca E., Pendiuk Goncalves, Jenifer and Wolfram, Joy (2023). Extracellular Vesicle and Lipoprotein Interactions. Nano Letters, 24 (1), 1-8. doi: 10.1021/acs.nanolett.3c03579

  • Iannotta, Dalila, A, Amruta, Kijas, Amanda W., Rowan, Alan E. and Wolfram, Joy (2023). Entry and exit of extracellular vesicles to and from the blood circulation. Nature Nanotechnology, 19 (1), 137-20. doi: 10.1038/s41565-023-01522-z

  • Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240

  • Iannotta, Dalila, Goncalves, Jenifer P., Ghebosu, Raluca E., Gopalakrishnan, Aswathi, Cooper-White, Justin and Wolfram, Joy (2023). Transforming undergraduate laboratory courses with interlinked real-world challenges. Trends in Biotechnology, 42 (1), 1-4. doi: 10.1016/j.tibtech.2023.10.006

  • Amruta, A., Iannotta, Dalila, Cheetham, Seth W., Lammers, Twan and Wolfram, Joy (2023). Vasculature organotropism in drug delivery. Advanced Drug Delivery Reviews, 201 115054, 1-13. doi: 10.1016/j.addr.2023.115054

  • Chen, Siyu, Iannotta, Dalila, O'Mara, Megan L., Goncalves, Jenifer Pendiuk and Wolfram, Joy (2023). Extracellular vesicle lipids in cancer immunoevasion. Trends in Cancer, 9 (11), 883-886. doi: 10.1016/j.trecan.2023.08.006

  • Goncalves, Jenifer P., Ghebosu, Raluca E., Tan, Xuan Ning Sharon, Iannotta, Dalila, Koifman, Na'ama and Wolfram, Joy (2023). Hyaluronic acid: An overlooked extracellular vesicle contaminant. Journal of Extracellular Vesicles, 12 (9) 12362, e12362. doi: 10.1002/jev2.12362

  • Beetler, Danielle J., Bruno, Katelyn A., Watkins, Molly M., Xu, Vivian, Chekuri, Isha, Giresi, Presley, Di Florio, Damian N., Whelan, Emily R., Edenfield, Brandy H., Walker, Sierra A., Morales-Lara, Andrea C., Hill, Anneliese R., Jain, Angita, Auda, Matthew E., Macomb, Logan P., Shapiro, Kathryn A., Keegan, Kevin C., Wolfram, Joy, Behfar, Atta, Stalboerger, Paul G., Terzic, Andre, Farres, Houssam, Cooper, Leslie T. and Fairweather, DeLisa (2023). Reconstituted extracellular vesicles from human platelets decrease viral myocarditis in mice. Small, 19 (49) 2303317, e2303317. doi: 10.1002/smll.202303317

  • Ghodasara, Aayushi, Raza, Aun, Wolfram, Joy, Salomon, Carlos and Popat, Amirali (2023). Clinical translation of extracellular vesicles. Advanced Healthcare Materials, 12 (28) 2301010, e2301010. doi: 10.1002/adhm.202301010

  • Pendiuk Goncalves, Jenifer, Walker, Sierra A., Aguilar Díaz de león, Jesús S., Yang, Yubo, Davidovich, Irina, Busatto, Sara, Sarkaria, Jann, Talmon, Yeshayahu, Borges, Chad R. and Wolfram, Joy (2023). Glycan node analysis detects varying glycosaminoglycan levels in melanoma-derived extracellular vesicles. International Journal of Molecular Sciences, 24 (10) 8506, 1-13. doi: 10.3390/ijms24108506

  • Meneses, Kayleah M., Pandya, Prita, Lindemann, Jennifer A., Al-Qasrawi, Dania S., Argo, Ryan A., Weems, Celeste M., Beetler, Danielle J., Vijay, Geraldine V., Yan, Irene K., Wolfram, Joy, Patel, Tushar and Justilien, Verline (2023). RAB27B drives a cancer stem cell phenotype in NSCLC cells through enhanced extracellular vesicle secretion. Cancer Research Communications, 3 (4), 607-620. doi: 10.1158/2767-9764.crc-22-0425

  • Bian, Xiaohui, Conley, Sabena M., Eirin, Alfonso, Zimmerman Zuckerman, Eric A., Smith, Anastasia L., Gowan, Cody C., Snow, Zachary K., Jarmi, Tambi, Farres, Houssam, Erben, Young M., Hakaim, Albert G., Dietz, Matthew A., Zubair, Abba C., Wyles, Saranya P., Wolfram, Joy V., Lerman, Lilach O. and Hickson, LaTonya J. (2023). Diabetic kidney disease induces transcriptome alterations associated with angiogenesis activity in human mesenchymal stromal cells. Stem Cell Research and Therapy, 14 (1) 49, 49. doi: 10.1186/s13287-023-03269-9

  • Broad, Kelly, Walker, Sierra A., Davidovich, Irina, Witwer, Kenneth, Talmon, Yeshayahu and Wolfram, Joy (2023). Unraveling multilayered extracellular vesicles: Speculation on cause. Journal of Extracellular Vesicles, 12 (2) e12309, e12309. doi: 10.1002/jev2.12309

  • Bruno, Maria Chiara, Cristiano, Maria Chiara, Celia, Christian, d'Avanzo, Nicola, Mancuso, Antonia, Paolino, Donatella, Wolfram, Joy and Fresta, Massimo (2022). Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis. ACS Nano, 16 (12), 19665-19690. doi: 10.1021/acsnano.2c06393

  • Walker, Sierra A., Davidovich, Irina, Yang, Yubo, Lai, Andrew, Goncalves, Jenifer Pendiuk, Deliwala, Vatsal, Busatto, Sara, Shapiro, Shane, Koifman, Na’ama, Salomon, Carlos, Talmon, Yeshayahu and Wolfram, Joy (2022). Sucrose-based cryoprotective storage of extracellular vesicles. Extracellular Vesicle, 1 100016, 100016. doi: 10.1016/j.vesic.2022.100016

  • Beetler, Danielle J., Di Florio, Damian N., Bruno, Katelyn A., Ikezu, Tsuneya, March, Keith L., Cooper, Leslie T., Wolfram, Joy and Fairweather, DeLisa (2022). Extracellular vesicles as personalized medicine. Molecular Aspects of Medicine, 91 101155, 1-14. doi: 10.1016/j.mam.2022.101155

  • Liskey, Delaney, Cynkin, Laurie and Wolfram, Joy (2022). Patients as biomedical researchers. Trends in Molecular Medicine, 28 (12), 1022-1024. doi: 10.1016/j.molmed.2022.09.002

  • Goncalves, Jenifer P., Deliwala, Vatsal J., Kolarich, Daniel, Souza-Fonseca-Guimaraes, Fernando and Wolfram, Joy (2022). The cancer cell-derived extracellular vesicle glycocode in immunoevasion. Trends in Immunology, 43 (11), 864-867. doi: 10.1016/j.it.2022.09.004

  • Busatto, Sara, Yang, Yubo, Iannotta, Dalila, Davidovich, Irina, Talmon, Yeshayahu and Wolfram, Joy (2022). Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays. Journal of Extracellular Vesicles, 11 (4) e12202, e12202. doi: 10.1002/jev2.12202

  • Yang, Man, Walker, Sierra A., Aguilar Díaz de León, Jesús S., Davidovich, Irina, Broad, Kelly, Talmon, Yeshayahu, Borges, Chad R. and Wolfram, Joy (2022). Extracellular vesicle glucose transporter-1 and glycan features in monocyte-endothelial inflammatory interactions. Nanomedicine, 42 102515, 102515. doi: 10.1016/j.nano.2022.102515

  • Wang, Xinghua, Pham, Anthony, Kang, Lu, Walker, Sierra A., Davidovich, Irina, Iannotta, Dalila, Terkonda, Sarvam P., Shapiro, Shane, Talmon, Yeshayahu, Pham, Si and Wolfram, Joy (2022). Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines. Pharmaceutics, 14 (1) 16, 16. doi: 10.3390/pharmaceutics14010016

  • Iannotta, Dalila, Yang, Man, Celia, Christian, Di Marzio, Luisa and Wolfram, Joy (2021). Extracellular vesicle therapeutics from plasma and adipose tissue. Nano Today, 39 101159, 101159. doi: 10.1016/j.nantod.2021.101159

  • Busatto, Sara, Iannotta, Dalila, Walker, Sierra A., Di Marzio, Luisa and Wolfram, Joy (2021). A simple and quick method for loading proteins in extracellular vesicles. Pharmaceuticals, 14 (4) 356, 356. doi: 10.3390/ph14040356

  • Hu, Tony, Wolfram, Joy and Srivastava, Sudhir (2021). Extracellular vesicles in cancer detection: hopes and hypes. Trends in Cancer, 7 (2), 122-133. doi: 10.1016/j.trecan.2020.09.003

  • Witwer, Kenneth W. and Wolfram, Joy (2021). Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nature Reviews Materials, 6 (2), 103-106. doi: 10.1038/s41578-020-00277-6

  • Walker, Sierra A., Pham, Anthony, Nizzero, Sara, Kim, Mingee, Riter, Bob, Bletz, Julie, Judge, Sheila, Phillips, Benette, Noble, Dorottya, Murray, Diana, Wetzel, Erin, Samson, Susan, McMahon, Mariah, Flink, Carl, Couch, Jennifer, Tomlin, Claire, Swanson, Kristin, Anderson, Alexander R. A., Odde, David, Shen, Haifa, Hughes, Shannon, Zahir, Nastaran, Enderling, Heiko and Wolfram, Joy (2021). Education and outreach in physical sciences in oncology. Trends in Cancer, 7 (1), 3-9. doi: 10.1016/j.trecan.2020.10.007

  • Ali, Mojahid, Pham, Anthony, Wang, Xinghua, Wolfram, Joy and Pham, Si (2020). Extracellular vesicles for treatment of solid organ ischemia-reperfusion injury. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 20 (12), 3294-3307. doi: 10.1111/ajt.16164

  • Busatto, Sara, Yang, Yubo, Walker, Sierra A., Davidovich, Irina, Lin, Wan-Hsin, Lewis-Tuffin, Laura, Anastasiadis, Panagiotis Z., Sarkaria, Jann, Talmon, Yeshayahu, Wurtz, Gregory and Wolfram, Joy (2020). Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein. Journal of Nanobiotechnology, 18 (1) 162, 162. doi: 10.1186/s12951-020-00722-2

  • Walker, Sierra A., Aguilar Díaz De León, Jesús S., Busatto, Sara, Wurtz, Gregory A., Zubair, Abba C., Borges, Chad R. and Wolfram, Joy (2020). Glycan node analysis of plasma-derived extracellular vesicles. Cells, 9 (9) 5277, 1946-15. doi: 10.3390/cells9091946

  • Busatto, Sara, Walker, Sierra A., Grayson, Whisper, Pham, Anthony, Tian, Ming, Nesto, Nicole, Barklund, Jacqueline and Wolfram, Joy (2020). Lipoprotein-based drug delivery. Advanced drug delivery reviews, 159, 377-390. doi: 10.1016/j.addr.2020.08.003

  • Hu, Tony Y., Frieman, Matthew and Wolfram, Joy (2020). Insights from nanomedicine into chloroquine efficacy against COVID-19. Nature Nanotechnology, 15 (4), 247-249. doi: 10.1038/s41565-020-0674-9

  • Tian, Ming, Ticer, Taylor, Wang, Qikun, Walker, Sierra, Pham, Anthony, Suh, Annie, Busatto, Sara, Davidovich, Irina, Al-Kharboosh, Rawan, Lewis-Tuffin, Laura, Ji, Baoan, Quinones-Hinojosa, Alfredo, Talmon, Yeshayahu, Shapiro, Shane, Rueckert, Felix and Wolfram, Joy (2020). Adipose-derived biogenic nanoparticles for suppression of inflammation. Small, 16 (10) 1904064, 1-13. doi: 10.1002/smll.201904064

  • Martins, João Pedro, das Neves, José, de la Fuente, María, Celia, Christian, Florindo, Helena, Günday-Türeli, Nazende, Popat, Amirali, Santos, José Luis, Sousa, Flávia, Schmid, Ruth, Wolfram, Joy, Sarmento, Bruno and Santos, Hélder A. (2020). The solid progress of nanomedicine. Drug Delivery and Translational Research, 10 (3), 726-729. doi: 10.1007/s13346-020-00743-2

  • Walker, Sierra, Busatto, Sara, Pham, Anthony, Tian, Ming, Suh, Annie, Carson, Kelsey, Quintero, Astrid, Lafrence, Maria, Malik, Hanna, Santana, Moises X and Wolfram, Joy (2019). Extracellular vesicle-based drug delivery systems for cancer treatment. Theranostics, 9 (26), 8001-8017. doi: 10.7150/thno.37097

  • Nizzero, Sara, Li, Feng, Zhang, Guodong, Venuta, Alessandro, Borsoi, Carlotta, Mai, Junhua, Shen, Haifa, Wolfram, Joy, Li, Zheng, Blanco, Elvin and Ferrari, Mauro (2019). Systematic comparison of methods for determining the in vivo biodistribution of porous nanostructured injectable inorganic particles. Acta Biomaterialia, 97, 501-512. doi: 10.1016/j.actbio.2019.08.002

  • Suh, Annie, Pham, Anthony, Cress, Mikel Jean, Pincelli, Thais, TerKonda, Sarvam P., Bruce, Alison J., Zubair, Abba C., Wolfram, Joy and Shapiro, Shane A. (2019). Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation. Ageing Research Reviews, 54 100933. doi: 10.1016/j.arr.2019.100933

  • Leong, Hon S., Butler, Kimberly S., Brinker, C. Jeffrey, Azzawi, May, Conlan, Steve, Dufès, Christine, Owen, Andrew, Rannard, Steve, Scott, Chris, Chen, Chunying, Dobrovolskaia, Marina A., Kozlov, Serguei V., Prina-Mello, Adriele, Schmid, Ruth, Wick, Peter, Caputo, Fanny, Boisseau, Patrick, Crist, Rachael M., McNeil, Scott E., Fadeel, Bengt, Tran, Lang, Hansen, Steffen Foss, Hartmann, Nanna B., Clausen, Lauge P. W., Skjolding, Lars M., Baun, Anders, Ågerstrand, Marlene, Gu, Zhen, Lamprou, Dimitrios A. ... Pastore, Chiara (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine (Nature Nanotechnology, (2019), 14, 7, (629-635), 10.1038/s41565-019-0496-9). Nature Nanotechnology, 14 (9), 902-902. doi: 10.1038/s41565-019-0538-3

  • Leong, Hon S., Butler, Kimberly S., Brinker, C. Jeffrey, Azzawi, May, Conlan, Steve, Dufès, Christine, Owen, Andrew, Rannard, Steve, Scott, Chris, Chen, Chunying, Dobrovolskaia, Marina A., Kozlov, Serguei V., Prina-Mello, Adriele, Schmid, Ruth, Wick, Peter, Caputo, Fanny, Boisseau, Patrick, Crist, Rachael M., McNeil, Scott E., Fadeel, Bengt, Tran, Lang, Hansen, Steffen Foss, Hartmann, Nanna B., Clausen, Lauge P. W., Skjolding, Lars M., Baun, Anders, Ågerstrand, Marlene, Gu, Zhen, Lamprou, Dimitrios A. ... Pastore, Chiara (2019). Publisher Correction: On the issue of transparency and reproducibility in nanomedicine (Nature Nanotechnology, (2019), 14, 7, (629-635), 10.1038/s41565-019-0496-9). Nature Nanotechnology, 14 (8), 811-811. doi: 10.1038/s41565-019-0523-x

  • Leong, Hon S., Butler, Kimberly S., Brinker, C. Jeffrey, Azzawi, May, Conlan, Steve, Dufés, Christine, Owen, Andrew, Rannard, Steve, Scott, Chris, Chen, Chunying, Dobrovolskaia, Marina A., Kozlov, Serguei V., Prina-Mello, Adriele, Schmid, Ruth, Wick, Peter, Caputo, Fanny, Boisseau, Patrick, Crist, Rachael M., McNeil, Scott E., Fadeel, Bengt, Tran, Lang, Hansen, Steffen Foss, Hartmann, Nanna B., Clausen, Lauge P. W., Skjolding, Lars M., Baun, Anders, Ågerstrand, Marlene, Gu, Zhen, Lamprou, Dimitrios A. ... Pastore, Chiara (2019). On the issue of transparency and reproducibility in nanomedicine. Nature Nanotechnology, 14 (7), 629-635. doi: 10.1038/s41565-019-0496-9

  • Busatto, Sara, Pham, Anthony, Suh, Annie, Shapiro, Shane and Wolfram, Joy (2019). Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles. Biomedical Microdevices, 21 (2) 46, 46. doi: 10.1007/s10544-019-0396-7

  • Wolfram, Joy and Ferrari, Mauro (2019). Clinical cancer nanomedicine. Nano Today, 25, 85-98. doi: 10.1016/j.nantod.2019.02.005

  • Busatto, Sara, Vilanilam, George, Ticer, Taylor, Lin, Wen-Lang, Dickson, Dennis, Shapiro, Shane, Bergese, Paolo and Wolfram, Joy (2018). Tangential flow filtration for highly efficient concentration of extracellular vesicles from large volumes of fluid. Cells, 7 (12) 273, 273. doi: 10.3390/cells7120273

  • Thery, Clotilde, Witwer, Kenneth W., Aikawa, Elena, Jose Alcaraz, Maria, Anderson, Johnathon D., Andriantsitohaina, Ramaroson, Antoniou, Anna, Arab, Tanina, Archer, Fabienne, Atkin-Smith, Georgia K., Ayre, D. Craig, Bach, Jean-Marie, Bachurski, Daniel, Baharvand, Hossein, Balaj, Leonora, Baldacchino, Shawn, Bauer, Natalie N., Baxter, Amy A., Bebawy, Mary, Beckham, Carla, Zavec, Apolonija Bedina, Benmoussa, Abderrahim, Berardi, Anna C., Bergese, Paolo, Bielska, Ewa, Blenkiron, Cherie, Bobis-Wozowicz, Sylwia, Boilard, Eric, Boireau, Wilfrid ... Zuba-Surma, Ewa K. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles, 7 (1) 1535750, 1535750. doi: 10.1080/20013078.2018.1535750

  • Pelt, Joe, Busatto, Sara, Ferrari, Mauro, Thompson, E. Aubrey, Mody, Kabir and Wolfram, Joy (2018). Chloroquine and nanoparticle drug delivery: A promising combination. Pharmacology and Therapeutics, 191, 43-49. doi: 10.1016/j.pharmthera.2018.06.007

  • Mu, Chaofeng, Wu, Xiaoyan, Zhou, Xinyu, Wolfram, Joy, Shen, Jianliang, Zhang, Dechen, Mai, Junhua, Xia, Xiaojun, Holder, Ashley M., Ferrari, Mauro, Liu, Xuewu and Shen, Haifa (2018). Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer. Clinical Cancer Research, 24 (19), 4900-4912. doi: 10.1158/1078-0432.CCR-17-3872

  • Borrelli, David A., Yankson, Kiera, Shukla, Neha, Vilanilam, George, Ticer, Taylor and Wolfram, Joy (2018). Extracellular vesicle therapeutics for liver disease. Journal of Controlled Release, 273, 86-98. doi: 10.1016/j.jconrel.2018.01.022

  • Liu, Haoran, Mai, Junhua, Shen, Jianliang, Wolfram, Joy, Li, Zhaoqi, Zhang, Guodong, Xu, Rong, Li, Yan, Mu, Chaofeng, Zu, Youli, Li, Xin, Lokesh, Ganesh L., Thiviyanathan, Varatharasa, Volk, David E., Gorenstein, David G., Ferrari, Mauro, Hu, Zhongbo and Shen, Haifa (2018). A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells. Theranostics, 8 (1), 31-44. doi: 10.7150/thno.21342

  • Wolfram, Joy, Nizzero, Sara, Liu, Haoran, Li, Feng, Zhang, Guodong, Li, Zheng, Shen, Haifa, Blanco, Elvin and Ferrari, Mauro (2017). A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery. Scientific Reports, 7 (1) 13738. doi: 10.1038/s41598-017-14221-2

  • Samuelsson, Emma, Shen, Haifa, Blanco, Elvin, Ferrari, Mauro and Wolfram, Joy (2017). Contribution of Kupffer cells to liposome accumulation in the liver. Colloids and Surfaces B: Biointerfaces, 158, 356-362. doi: 10.1016/j.colsurfb.2017.07.014

  • Khalid, Ayesha, Persano, Stefano, Shen, Haifa, Zhao, Yuliang, Blanco, Elvin, Ferrari, Mauro and Wolfram, Joy (2017). Strategies for improving drug delivery: nanocarriers and microenvironmental priming. Expert Opinion on Drug Delivery, 14 (7), 865-877. doi: 10.1080/17425247.2017.1243527

  • Shen, Jianliang, Kim, Han-Cheon, Wolfram, Joy, Mu, Chaofeng, Zhang, Wei, Liu, Haoran, Xie, Yan, Mai, Junhua, Zhang, Hang, Li, Zhi, Guevara, Maria, Mao, Zong-Wan and Shen, Haifa (2017). A liposome encapsulated ruthenium polypyridine complex as a theranostic platform for triple-negative breast cancer. Nano Letters, 17 (5), 2913-2920. doi: 10.1021/acs.nanolett.7b00132

  • Shen, Jianliang, Liu, Haoran, Mu, Chaofeng, Wolfram, Joy, Zhang, Wei, Kim, Han-Cheon, Zhu, Guixian, Hu, Zhongbo, Ji, Liang-Nian, Liu, Xuewu, Ferrari, Mauro, Mao, Zong-Wan and Shen, Haifa (2017). Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Nanoscale, 9 (16), 5329-5341. doi: 10.1039/c7nr00377c

  • Shen, Jianliang, Wolfram, Joy, Ferrari, Mauro and Shen, Haifa (2017). Taking the vehicle out of drug delivery. Materials Today, 20 (3), 95-97. doi: 10.1016/j.mattod.2017.01.013

  • Venuta, Alessandro, Wolfram, Joy, Shen, Haifa and Ferrari, Mauro (2017). Post-nano strategies for drug delivery: multistage porous silicon microvectors. Journal of Materials Chemistry B, 5 (2), 207-219. doi: 10.1039/C6TB01978A

  • Mi, Yu, Wolfram, Joy, Mu, Chaofeng, Liu, Xuewu, Blanco, Elvin, Shen, Haifa and Ferrari, Mauro (2016). Enzyme-responsive multistage vector for drug delivery to tumor tissue. Pharmacological Research, 113, 92-99. doi: 10.1016/j.phrs.2016.08.024

  • Persano, Stefano, Guevara, Maria L., Wolfram, Joy, Blanco, Elvin, Shen, Haifa, Ferrari, Mauro and Pompa, Pier Paolo (2016). Label-free isothermal amplification assay for specific and highly sensitive colorimetric miRNA detection. ACS Omega, 1 (3), 448-455. doi: 10.1021/acsomega.6b00109

  • Scott, Bronwyn, Shen, Jianliang, Nizzero, Sara, Boom, Kathryn, Persano, Stefano, Mi, Yu, Liu, Xuewu, Zhao, Yuliang, Blanco, Elvin, Shen, Haifa, Ferrari, Mauro and Wolfram, Joy (2016). A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacological Research, 111, 413-421. doi: 10.1016/j.phrs.2016.07.005

  • Wolfram, Joy, Scott, Bronwyn, Boom, Kathryn, Shen, Jianliang, Borsoi, Carlotta, Suri, Krishna, Grande, Rossella, Fresta, Massimo, Celia, Christian, Zhao, Yuliang, Shen, Haifa and Ferrari, Mauro (2016). Hesperetin liposomes for cancer therapy. Current Drug Delivery, 13 (5), 711-719. doi: 10.2174/1567201812666151027142412

  • Mi, Yu, Mu, Chaofeng, Wolfram, Joy, Deng, Zaian, Hu, Tony Ye, Liu, Xuewu, Blanco, Elvin, Shen, Haifa and Ferrari, Mauro (2016). A micro/nano composite for combination treatment of melanoma lung metastasis. Advanced Healthcare Materials, 5 (8), 936-946. doi: 10.1002/adhm.201500910

  • Wolfram, Joy, Shen, Haifa and Ferrari, Mauro (2015). Multistage vector (MSV) therapeutics. Journal of Controlled Release, 219, 406-415. doi: 10.1016/j.jconrel.2015.08.010

  • Scavo, Maria Principia, Gentile, Emanuela, Wolfram, Joy, Gu, Jianhua, Barone, Michele, Evangelopoulos, Michael, Martinez, Jonathan O., Liu, Xuewu, Celia, Christian, Tasciotti, Ennio, Vilar, Eduardo and Shen, Haifa (2015). Multistage vector delivery of sulindac and silymarin for prevention of colon cancer. Colloids and Surfaces B: Biointerfaces, 136, 694-703. doi: 10.1016/j.colsurfb.2015.10.005

  • Khalid, Ayesha, Wolfram, Joy, Ferrari, Ilaria, Mu, Chaofeng, Mai, Junhua, Yang, Zhizhou, Zhao, Yuliang, Ferrari, Mauro, Ma, Xiaojing and Shen, Haifa (2015). Recent advances in discovering the role of CCL5 in metastatic breast cancer. Mini-Reviews in Medicinal Chemistry, 15 (13), 1063-1072. doi: 10.2174/138955751513150923094709

  • Yang, Zhizhou, Sun, Zhaorui, Liu, Hongmei, Ren, Yi, Shao, Danbing, Zhang, Wei, Lin, Jinfeng, Wolfram, Joy, Wang, Feng and Nie, Shinan (2015). Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis. Molecular Medicine Reports, 12 (1), 1091-1097. doi: 10.3892/mmr.2015.3537

  • Lin, Jinfeng, Sun, Zhaorui, Zhang, Wei, Liu, Hongmei, Shao, Danbing, Ren, Yi, Wen, Yanfang, Cao, Liping, Wolfram, Joy, Yang, Zhizhou and Nie, Shinan (2015). Protective effects of intestinal trefoil factor (ITF) on gastric mucosal epithelium through activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Molecular and Cellular Biochemistry: an international journal for chemical biology in health and disease, 404 (1-2), 263-270. doi: 10.1007/s11010-015-2386-2

  • Pasut, Gianfranco, Paolino, Donatella, Celia, Christian, Mero, Anna, Joseph, Adrian Steve, Wolfram, Joy, Cosco, Donato, Schiavon, Oddone, Shen, Haifa and Fresta, Massimo (2015). Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy. Journal of Controlled Release, 199, 106-113. doi: 10.1016/j.jconrel.2014.12.008

  • Shen, Jianliang, Wu, Xiaoyan, Lee, Yeonju, Wolfram, Joy, Yang, Zhizhou, Mao, Zong-Wan, Ferrari, Mauro and Shen, Haifa (2015). Porous silicon microparticles for delivery of siRNA therapeutics. Journal of Visualized Experiments (95) e52075. doi: 10.3791/52075

  • Wolfram, Joy, Zhu, Motao, Yang, Yong, Shen, Jianliang, Gentile, Emanuela, Paolino, Donatella, Fresta, Massimo, Nie, Guangjun, Chen, Chunying, Shen, Haifa, Ferrari, Mauro and Zhao, Yuliang (2015). Safety of nanoparticles in medicine. Current Drug Targets, 16 (14), 1671-1681. doi: 10.2174/1389450115666140804124808

  • Wolfram, Joy, Yang, Yong, Shen, Jianliang, Moten, Asad, Chen, Chunying, Shen, Haifa, Ferrari, Mauro and Zhao, Yuliang (2014). The nano-plasma interface: Implications of the protein corona. Colloids and Surfaces B: Biointerfaces, 124, 17-24. doi: 10.1016/j.colsurfb.2014.02.035

  • Shen, Jianliang, Kim, Han-Cheon, Mu, Chaofeng, Gentile, Emanuela, Mai, Junhua, Wolfram, Joy, Ji, Liang-Nian, Ferrari, Mauro, Mao, Zong-wan and Shen, Haifa (2014). Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy. Advanced Healthcare Materials, 3 (10), 1629-1637. doi: 10.1002/adhm.201400103

  • Jiang, Xionghua, Chen, Zhenxing, Wolfram, Joy, Wei, Zhongxian, Shen, Yuqiu and Yang, Zhizhou (2014). The impact of lubricants on the precision lapping process. Microscopy and Microanalysis, 20 (6), 1708-1714. doi: 10.1017/S1431927614013397

  • Yang, Yong, Wolfram, Joy, Fang, Xiaohong, Shen, Haifa and Ferrari, Mauro (2014). Polyarginine induces an antitumor immune response through binding to toll-like receptor 4. Small, 10 (7), 1250-1254. doi: 10.1002/smll.201302887

  • Wolfram, Joy, Suri, Krishna, Yang, Yong, Shen, Jianliang, Celia, Christian, Fresta, Massimo, Zhao, Yuliang, Shen, Haifa and Ferrari, Mauro (2014). Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids and Surfaces B: Biointerfaces, 114, 294-300. doi: 10.1016/j.colsurfb.2013.10.009

  • Rauhamäki, Virve, Wolfram, Joy, Jokitalo, Eija, Hanski, Ilkka and Dahlhoff, Elizabeth P. (2014). Differences in the aerobic capacity of flight muscles between butterfly populations and species with dissimilar flight abilities. PLoS ONE, 9 (1) e78069, e78069. doi: 10.1371/journal.pone.0078069

  • Shen, Jianliang, Kim, Han-Cheon, Su, Hua, Wang, Feng, Wolfram, Joy, Kirui, Dickson, Mai, Junhua, Mu, Chaofeng, Ji, Liang-Nian, Mao, Zong-Wan and Shen, Haifa (2014). Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics. Theranostics, 4 (5), 487-497. doi: 10.7150/thno.8263

  • Wolfram, Joy, Suri, Krishna, Huang, Yi, Molinaro, Roberto, Borsoi, Carlotta, Scott, Bronwyn, Boom, Kathryn, Paolino, Donatella, Fresta, Massimo, Wang, Jianghua, Ferrari, Mauro, Celia, Christian and Shen, Haifa (2014). Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells. Journal of Microencapsulation, 31 (5), 501-507. doi: 10.3109/02652048.2013.879932

  • Jiang, Xionghua, Chen, Zhenxing, Wolfram, Joy and Yang, Zhizhou (2014). Mechanistic features of nanodiamonds in the lapping of magnetic heads. Scientific World Journal, 2014 326427. doi: 10.1155/2014/326427

  • Wolfram, Joy, Zhu, Motao, Yang, Yong, Shen, Jianliang, Gentile, Emanuela, Paolino, Donatella, Fresta, Massimo, Nie, Guangjun, Chen, Chunying, Shen, Haifa, Ferrari, Mauro and Zhao, Yuliang (2014). Safety of nanoparticles in medicine. Current Drug Targets, 15 (10) A001.

  • Paolino, Donatella, Cosco, Donato, Gaspari, Marco, Celano, Marilena, Wolfram, Joy, Voce, Pasquale, Puxeddu, Efisio, Filetti, Sebastiano, Celia, Christian, Ferrari, Mauro, Russo, Diego and Fresta, Massimo (2014). Targeting the thyroid gland with thyroid-stimulating hormone (TSH)-nanoliposomes. Biomaterials, 35 (25), 7101-7109. doi: 10.1016/j.biomaterials.2014.04.088

  • Yang, Yong, Wolfram, Joy, Shen, Jianliang, Zhao, Yuliang, Fang, Xiaohong, Shen, Haifa and Ferrari, Mauro (2013). Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane. FEBS Letters, 587 (24), 3912-3920. doi: 10.1016/j.febslet.2013.10.041

  • Celia, Christian, Trapasso, Elena, Locatelli, Marcello, Navarra, Michele, Ventura, Cinzia Anna, Wolfram, Joy, Carafa, Maria, Morittu, Valeria Maria, Britti, Domenico, Di Marzio, Luisa and Paolino, Donatella (2013). Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids and Surfaces B: Biointerfaces, 112, 548-553. doi: 10.1016/j.colsurfb.2013.09.017

  • Gentile, Emanuela, Cilurzo, Felisa, Di Marzio, Luisa, Carafa, Maria, Ventura, Cinzia Anna, Wolfram, Joy, Paolino, Donatella and Celia, Christian (2013). Liposomal chemotherapeutics. Future Oncology, 9 (12), 1849-1859. doi: 10.2217/FON.13.146

  • Shen, Jianliang, Xu, Rong, Mai, Junhua, Kim, Han-Cheon, Guo, Xiaojing, Qin, Guoting, Yang, Yong, Wolfram, Joy, Mu, Chaofeng, Xia, Xiaojun, Gu, Jianhua, Liu, Xuewu, Mao, Zong-Wan, Ferrari, Mauro and Shen, Haifa (2013). High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS Nano, 7 (11), 9867-9880. doi: 10.1021/nn4035316

  • Yang, Yong, Wolfram, Joy, Boom, Kathryn, Fang, Xiaohong, Shen, Haifa and Ferrari, Mauro (2013). Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells. Cell Biochemistry and Function, 31 (5), 374-379. doi: 10.1002/cbf.2905

  • Molinaro, Roberto, Wolfram, Joy, Federico, Cinzia, Cilurzo, Felisa, Di Marzio, Luisa, Ventura, Cinzia A., Carafa, Maria, Celia, Christian and Fresta, Massimo (2013). Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors. Expert Opinion on Drug Delivery, 10 (12), 1653-1668. doi: 10.1517/17425247.2013.840286

  • Yang, Yong, Wolfram, Joy, Shen, Haifa, Fang, Xiaohong and Ferrari, Mauro (2012). Hesperetin: An inhibitor of the transforming growth factor-β (TGF-β) signaling pathway. European Journal of Medicinal Chemistry, 58, 390-395. doi: 10.1016/j.ejmech.2012.10.028

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Please contact the Wolfram Laboratory if you are interested in PhD projects on:

    - Deveoping extracellular vesicle therapeutics for cardiovascular inflammation

    - Understanding the contribution of extracellular vesicles in breast cancer immunoevasion