The University of Queensland

Calcitonin

Ostrovskaya, A., Findlay, D. M., Sexton, P. M. and Furness, S. G. B. (2017). Calcitonin. Reference module in neuroscience and biobehavioral psychology. (pp. - ) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-809324-5.03223-5

Understanding amylin receptors

Just, Rasmus, Simms, John, Furness, Sebastian G. B., Christopoulos, Arthur and Sexton, Patrick M. (2009). Understanding amylin receptors. The calcitonin gene-related peptide family. (pp. 41-57) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-90-481-2909-6_3

Role of G protein‐coupled receptor kinases (<scp>GRKs</scp>) in β₂‐adrenoceptor‐mediated glucose uptake

Ham, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J. and Hutchinson, Dana S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research & Perspectives, 12 (1) e1176, e1176. doi: 10.1002/prp2.1176

Cardiac human bitter taste receptors contain naturally occurring variants that alter function

Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932

Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre

Ringuet, Mitchell T., Koo, Ada, Furness, Sebastian G. B., McDougall, Stuart J. and Furness, John B. (2023). Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of Physiology, 601 (23), 5195-5211. doi: 10.1113/jp285217

G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a

Ringuet, Mitchell Ty, Furness, John Barton and Furness, Sebastian George Barton (2022). G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a. Journal of Neuroendocrinology, 34 (9) e13077, 1-14. doi: 10.1111/jne.13077

Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors

Piper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng and Furness, Sebastian G.B. (2022). Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Biochemical Pharmacology, 202 115115, 1-21. doi: 10.1016/j.bcp.2022.115115

Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol

Harikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M. and Miller, Laurence J. (2021). Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol. Frontiers in Endocrinology, 12 789957. doi: 10.3389/fendo.2021.789957

Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy

Wookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Mobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J. and Sexton, Patrick M. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLOS Biology, 19 (6) e3001295, e3001295. doi: 10.1371/journal.pbio.3001295

AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists

Fletcher, Madeleine M., Keov, Peter, Truong, Tin T., Mennen, Grace, Hick, Caroline A., Zhao, Peishen, Furness, Sebastian G.B., Kruse, Thomas, Clausen, Trine R., Wootten, Denise and Sexton, Patrick M. (2021). AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists. Journal of Pharmacology and Experimental Therapeutics, 377 (3), 417-440. doi: 10.1124/jpet.121.000567

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

Furness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A. and Furness, Sebastian G. B. (2021). Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers. Neurogastroenterology and Motility, 33 (5) e14051. doi: 10.1111/nmo.14051

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

Liu, Mengjie, Whitfield, Emily A., Fothergill, Linda J., Furness, John B., Wade, John D., Furness, Sebastian G.B. and Hossain, Mohammed Akhter (2020). Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications, 533 (3), 559-564. doi: 10.1016/j.bbrc.2020.09.028

Differential GLP-1R binding and activation by peptide and non-peptide agonists

Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Differential GLP-1R binding and activation by peptide and non-peptide agonists. Molecular Cell, 80 (3), 485-500.e7. doi: 10.1016/j.molcel.2020.09.020

Structure and dynamics of the active Gs-coupled human secretin receptor

Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2020). Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1) 4137, 4137. doi: 10.1038/s41467-020-17791-4

Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins

Liang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise and Sexton, Patrick M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology and Translational Science, 3 (2), 263-284. doi: 10.1021/acsptsci.9b00080

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790), 432-436. doi: 10.1038/s41586-019-1902-z

Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma

Gupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12, 175883592097811. doi: 10.1177/1758835920978110

The nature of efficacy at G protein-coupled receptors

Zhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647

TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum

Nguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205

Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors

Draper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054

Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor

Pham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor. ACS Pharmacology and Translational Science, 2 (3), 183-197. doi: 10.1021/acsptsci.9b00010

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S., Stringer, Brett W., Wookey, Peter J., Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G.B. (2019). Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer, 19 (1) 157, 157. doi: 10.1186/s12885-019-5369-y

The molecular control of calcitonin receptor signaling

dal Maso, Emma, Glukhova, Alisa, Zhu, Yue, Garcia-Nafria, Javier, Tate, Christopher G., Atanasio, Silvia, Reynolds, Christopher A., Ramírez-Aportela, Erney, Carazo, Jose-Maria, Hick, Caroline A., Furness, Sebastian G. B., Hay, Debbie L., Liang, Yi-Lynn, Miller, Laurence J., Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). The molecular control of calcitonin receptor signaling. ACS Pharmacology and Translational Science, 2 (1), 31-51. doi: 10.1021/acsptsci.8b00056

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Furness, S. G. B., Christopoulos, A., Sexton, P. M. and Wootten, D. (2018). Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1. Biochemical Pharmacology, 156, 223-240. doi: 10.1016/j.bcp.2018.08.033

Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination

Liang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T., May, Lauren T., Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G. B. (2018). Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacology and Translational Science, 1 (1), 12-20. doi: 10.1021/acsptsci.8b00017

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Draper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa and Christopoulos, Arthur (2018). Structure of the adenosine-bound human adenosine A1 receptor–Gi complex. Nature, 558 (7711), 559-563. doi: 10.1038/s41586-018-0236-6

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B. and Wootten, Denise (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150, 214-244. doi: 10.1016/j.bcp.2018.02.005

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M. and Wootten, Denise (2018). Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex. Nature, 555 (7694), 121-125. doi: 10.1038/nature25773

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, Emma, Just, Rasmus, Hick, Caroline, Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise and Furness, Sebastian G.B. (2018). Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochemical Pharmacology, 148, 111-129. doi: 10.1016/j.bcp.2017.12.016

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Gilabert-Oriol, Roger, Furness, Sebastian G. B., Stringer, Brett W., Weng, Alexander, Fuchs, Hendrik, Day, Bryan W., Kourakis, Angela, Boyd, Andrew W., Hare, David L., Thakur, Mayank, Johns, Terrance G. and Wookey, Peter J. (2017). Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunology, Immunotherapy, 66 (9), 1217-1228. doi: 10.1007/s00262-017-2013-z

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios and Sexton, Patrick M. (2017). Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546 (7656), 118-123. doi: 10.1038/nature22327

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

Furness, Sebastian G. B., Wootten, Denise and Sexton, Patrick M (2017). What determines the magnitude of cellular response for activation of G protein-coupled receptors?. Cell Cycle, 16 (5), 392-394. doi: 10.1080/15384101.2016.1271634

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, Sebastian George Barton, Liang, Yi-Lynn, Nowell, Cameron James, Halls, Michelle Louise, Wookey, Peter John, Dal Maso, Emma, Inoue, Asuka, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick Michael (2016). Ligand-dependent modulation of G protein conformation alters drug efficacy. Cell, 167 (3), 739-749. doi: 10.1016/j.cell.2016.09.021

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118, 68-87. doi: 10.1016/j.bcp.2016.08.015

The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism

Wootten, Denise, Reynolds, Christopher A, Smith, Kevin J, Mobarec, Juan C, Koole, Cassandra, Savage, Emilia E, Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G B, Liu, Mengjie, Thompson, Philip E, Miller, Laurence J, Christopoulos, Arthur and Sexton, Patrick M (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), 1632-1643. doi: 10.1016/j.cell.2016.05.023

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures

Wootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures. Molecular Pharmacology, 89 (3), 335-47. doi: 10.1124/mol.115.101246

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

Furness, S.G.B., Hare, D.L., Kourakis, A., Turnley, A.M. and Wookey, P.J. (2016). A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death. Cell Death Discovery, 2 (1) 16062, 1-9. doi: 10.1038/cddiscovery.2016.62

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

Andreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation

Pabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

Savage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013

Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin

Willard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling

Hao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109

Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor

Sato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651

Consequences of splice variation on Secretin family G protein-coupled receptor function

Furness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x

The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172

Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x

Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator

Whelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927

The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Furness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004

Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications

Dave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200

Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors

Morfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

Furness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011

Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS

Dave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001

Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins

Tan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426

Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis

Furness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Koole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236