Dr Jake O'Donnell

Research Fellow

School of Chemistry and Molecular Biosciences
Faculty of Science

Overview

Research Interests

  • Monoclonal Antibody Development
    We have developed a pipeline for rapid flow cytometry and cell-sorting-based development of either mouse or human monoclonal antibodies with potential uses as research tools or therapies.
  • Human T-lymphotropic virus 1 (HTLV-1) and Adult T cell Leukemia/Lymphoma (ATLL)
    We have interests in the development of therapies for treatment of HTLV-1 and ATLL using basic research principles and structural biological approaches.
  • Understanding the impacts of vaccine adjuvants on immune responses
    We have interests in characterising the impacts that specific antigen/adjuvant pairings have in vaccine development, and how this understanding can guide adjuvant selection in vaccine development
  • The structural basis for anti-retroviral efficacy for novel indications
    We have interest in understanding the applicability and potential efficacy of existing and novel anti-retroviral therapies for treatment of different retroviral infections. Our current focuses are on HTLV-1 and Koala Retrovirus.

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Biomedical Science (Honours), The University of Queensland

Publications

View all Publications

Publications

Journal Article

Conference Publication

  • de Oliveira, A. Lepletier, Madore, J., O'donnell, S., Johnston, R. L., Eastgate, M., Mallardo, D., Ascierto, P. A., Massi, D., Merelli, B., Mandala, M., Wilmott, J. S., Bald, T., Stagg, J., Routy, B., Long, G. V., Scolyer, R. A., Waddell, N., Dougall, W. C., Teng, M. W. L. and Smyth, M. (2019). Resistance to immunotherapy is associated with high parenchymal PD1+CD8+/CD8+T cells (PD1tR) driven by tumour CD155. Immuno-Oncology Congress of the European-Society-for-Medical-Oncology (ESMO), Geneva, Switzerland, 11-14 December 2019. Oxford, United Kingdom: Oxford University Press.

  • Kaemmerer, Elke, Pere, Elena, Peters, Amelia A., Yapa, Kunsala T. D. S., Simpson, Fiona, O'Donnell, Jake, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). Calcium signalling and the acquisition of trastuzumab resistance in HER2 positive breast cancer cells. APSA ASCEPT Joint Scientific Meeting 2015, Hobart, TAS Australia, 29 November - 2 December 2015.

Grants (Administered at UQ)