The University of Queensland

Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation

Bell, Kirstine J., Saad, Sonia, Tillett, Bree J., McGuire, Helen M., Bordbar, Sara, Yap, Yu Anne, Nguyen, Long T., Wilkins, Marc R., Corley, Susan, Brodie, Shannon, Duong, Sussan, Wright, Courtney J., Twigg, Stephen, de St Groth, Barbara Fazekas, Harrison, Leonard C., Mackay, Charles R., Gurzov, Esteban N., Hamilton-Williams, Emma E. and Mariño, Eliana (2022). Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation. Microbiome, 10 (1) 9, 9. doi: 10.1186/s40168-021-01193-9

Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 Diabetes

Gavin, Patrick G., Mullaney, Jane A., Loo, Dorothy, Cao, Kim-Anh Lê, Gottlieb, Peter A., Hill, Michelle M., Zipris, Danny and Hamilton-Williams, Emma E. (2018). Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 Diabetes. Diabetes Care, 41 (10), 2178-2186. doi: 10.2337/dc18-0777

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1) 35, 1-16. doi: 10.1186/s40168-018-0417-4

Microbiota derived factors as drivers of type 1 diabetes

Tillett, Bree J. and Hamilton-Williams, Emma E. (2020). Microbiota derived factors as drivers of type 1 diabetes. The microbiome in health and disease. (pp. 215-235) Cambridge, MA United States: Academic Press.

Influence of toll-like receptor ligands and danger signals on T cell cross-tolerance

Hamilton-Williams, E. E. and Kurts, C. (2006). Influence of toll-like receptor ligands and danger signals on T cell cross-tolerance. Towards an understanding of initiating T cell immunity. (pp. 147-168) edited by Anthony T. Vella. Kerala, India: Research Signpost.

Faecal microbial transfer and complex carbohydrates mediate protection against COPD

Budden, Kurtis F, Shukla, Shakti D, Bowerman, Kate L, Vaughan, Annalicia, Gellatly, Shaan L, Wood, David L A, Lachner, Nancy, Idrees, Sobia, Rehman, Saima Firdous, Faiz, Alen, Patel, Vyoma K, Donovan, Chantal, Alemao, Charlotte A, Shen, Sj, Amorim, Nadia, Majumder, Rajib, Vanka, Kanth S, Mason, Jazz, Haw, Tatt Jhong, Tillet, Bree, Fricker, Michael, Keely, Simon, Hansbro, Nicole, Belz, Gabrielle T, Horvat, Jay, Ashhurst, Thomas, van Vreden, Caryn, McGuire, Helen, Fazekas de St Groth, Barbara ... Hansbro, Philip M (2024). Faecal microbial transfer and complex carbohydrates mediate protection against COPD. Gut, gutjnl-2023. doi: 10.1136/gutjnl-2023-330521

Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort

Oakey, Helena, Giles, Lynne C, Thomson, Rebecca L, Lê Cao, Kim-Anh, Ashwood, Pat, Brown, James D, Knight, Emma J, Barry, Simon C, Craig, Maria E, Colman, Peter G, Davis, Elizabeth A, Hamilton-Williams, Emma E, Harrison, Leonard C, Haynes, Aveni, Kim, Ki Wook, Mallitt, Kylie-Ann, McGorm, Kelly, Morahan, Grant, Rawlinson, William D, Sinnott, Richard O, Soldatos, Georgia, Wentworth, John M, Couper, Jennifer J, Penno, Megan A S and ENDIA Study Group (2023). Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort. Annals of Medicine, 55 (1) 2198255, 1-12. doi: 10.1080/07853890.2023.2198255

A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes

Harrison, Leonard C., Bandala-Sanchez, Esther, Oakey, Helena, Colman, Peter G., Watson, Kelly, Kim, Ki Wook, Wu, Roy, Hamilton-Williams, Emma E, Stone, Natalie L., Haynes, Aveni, Thomson, Rebecca L., Vuillermin, Peter J., Soldatos, Georgia, Rawlinson, William D., McGorm, Kelly J., Morahan, Grant, Sinnott, Richard O., Barry, Simon C., Wentworth, John M., Couper, Jennifer J., Penno, Megan As and ENDIA Study Group (2023). A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes. Journal of Diabetes Investigation, 14 (9), 1092-1100. doi: 10.1111/jdi.14031

Experiences of caregivers and at-risk children enrolled in a prospective pregnancy-birth cohort study into the causes of type 1 diabetes: the ENDIA Study

McGorm, Kelly D., Brown, James G., Roberts, Alison, Greenbank, Susan, Brasacchio, Daniella, Sawyer, Alyssa C. P., Oakey, Helena G., Colman, Peter E., Craig, Maria A., Davis, Elizabeth, Soldatos, Georgia L., Thomson, Rebecca M., Wentworth, John J., Couper, Jennifer, Penno, Megan A. S., ENDIA Study Group and Hamilton-Williams, Emma E. (2023). Experiences of caregivers and at-risk children enrolled in a prospective pregnancy-birth cohort study into the causes of type 1 diabetes: the ENDIA Study. Children, 10 (4), 1-12. doi: 10.3390/children10040637

Circulating biomarkers during progression to type 1 diabetes: a systematic review

Brenu, Ekua W., Harris, Mark and Hamilton-Williams, Emma E. (2023). Circulating biomarkers during progression to type 1 diabetes: a systematic review. Frontiers in Endocrinology, 14 1117076, 1117076. doi: 10.3389/fendo.2023.1117076

Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry

Okada, Mirei, Zhang, Vivian, Loaiza Naranjo, Jeniffer D., Tillett, Bree J., Wong, F. Susan, Steptoe, Raymond J., Bergot, Anne‐Sophie and Hamilton‐Williams, Emma E (2023). Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry. Immunology and Cell Biology, 101 (1), 36-48. doi: 10.1111/imcb.12593

Multi-omic interactions in the gut of children at the onset of islet autoimmunity

Gavin, Patrick G., Kim, Ki Wook, Craig, Maria E., Hill, Michelle M. and Hamilton-Williams, Emma E. (2022). Multi-omic interactions in the gut of children at the onset of islet autoimmunity. Microbiome, 10 (1) 230, 230. doi: 10.1186/s40168-022-01425-6

Mental health during late pregnancy and postpartum in mothers with and without type 1 diabetes: The ENDIA study

Hall, Madeleine, Oakey, Helena, Penno, Megan A. S., McGorm, Kelly, Anderson, Amanda J., Ashwood, Pat, Colman, Peter G., Craig, Maria E., Davis, Elizabeth A., Harris, Mark, Harrison, Leonard C., Haynes, Aveni, Morbey, Claire, Sinnott, Richard O., Soldatos, Georgia, Vuillermin, Peter J., Wentworth, John M., Thomson, Rebecca L., Couper, Jennifer J., ENDIA Study Group., Barry, Simon C., Craig, Maria E., Colman, Peter G., Couper, Jennifer J., Davis, Elizabeth A., Harris, Mark, Harrison, Leonard C., Haynes, Aveni, Kim, Ki Wook ... Cavenett, Leanne (2022). Mental health during late pregnancy and postpartum in mothers with and without type 1 diabetes: The ENDIA study. Diabetes Care, 45 (5), 1082-1090. doi: 10.2337/dc21-2335

Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation

Bell, Kirstine J., Saad, Sonia, Tillett, Bree J., McGuire, Helen M., Bordbar, Sara, Yap, Yu Anne, Nguyen, Long T., Wilkins, Marc R., Corley, Susan, Brodie, Shannon, Duong, Sussan, Wright, Courtney J., Twigg, Stephen, de St Groth, Barbara Fazekas, Harrison, Leonard C., Mackay, Charles R., Gurzov, Esteban N., Hamilton-Williams, Emma E. and Mariño, Eliana (2022). Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation. Microbiome, 10 (1) 9, 9. doi: 10.1186/s40168-021-01193-9

Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope

Buckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2022). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506

Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq

Rødahl, Inga, Gotley, James, Andersen, Stacey B., Yu, Meihua, Mehdi, Ahmed M., Christ, Angelika N., Hamilton-Williams, Emma E., Frazer, Ian H., Lukowski, Samuel W. and Chandra, Janin (2021). Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq. STAR Protocols, 2 (4) 100842, 1-27. doi: 10.1016/j.xpro.2021.100842

Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

Roth-Schulze, Alexandra J., Penno, Megan A. S., Ngui, Katrina M., Oakey, Helena, Bandala-Sanchez, Esther, Smith, Alannah D., Allnutt, Theo R., Thomson, Rebecca L., Vuillermin, Peter J., Craig, Maria E., Rawlinson, William D., Davis, Elizabeth A., Harris, Mark, Soldatos, Georgia, Colman, Peter G., Wentworth, John M., Haynes, Aveni, Barry, Simon C., Sinnott, Richard O., Morahan, Grant, Bediaga, Naiara G., Smyth, Gordon K., Papenfuss, Anthony T., Couper, Jennifer J., Harrison, Leonard C., ENDIA Study Group and Hamilton-Williams, Emma (2021). Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome. Microbiome, 9 (1) 167, 167. doi: 10.1186/s40168-021-01104-y

Queensland Family Cohort: a study protocol

Borg, Danielle, Rae, Kym, Fiveash, Corrine, Schagen, Johanna, James-McAlpine, Janelle, Friedlander, Frances, Thurston, Claire, Oliveri, Maria, Harmey, Theresa, Cavanagh, Erika, Edwards, Christopher, Fontanarosa, Davide, Perkins, Tony, de Zubicaray, Greig, Moritz, Karen, Kumar, Sailesh, Clifton, Vicki, Queensland Family Cohort Research Collaborative, Hamilton-Williams, Emma and Bora, Samudragupta (2021). Queensland Family Cohort: a study protocol. BMJ Open, 11 (6) e044463, 1-13. doi: 10.1136/bmjopen-2020-044463

Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment

Gavin, Patrick G., Wong, Justin, Loo, Dorothy, Zipris, Danny, Hill, Michelle M. and Hamilton-Williams, Emma E. (2021). Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment. Journal of Proteomics, 240 104219, 104219. doi: 10.1016/j.jprot.2021.104219

A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis

Hamilton-Williams, Emma E., Lorca, Graciela L., Norris, Jill M. and Dunne, Jessica L. (2021). A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis. Frontiers in Nutrition, 8 600756, 600756. doi: 10.3389/fnut.2021.600756

An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection

Yap, Yu Anne, McLeod, Keiran H., McKenzie, Craig I., Gavin, Patrick G., Davalos‐Salas, Mercedes, Richards, James L., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Eng, Vik Ven, Pearson, Jaclyn S., Hamilton‐Williams, Emma E., Mackay, Charles R. and Mariño, Eliana (2021). An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection. Clinical and Translational Immunology, 10 (1) e1233, e1233. doi: 10.1002/cti2.1233

Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes

Musthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315

Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes

Musthaffa, Yassmin, Nel, Hendrik J., Ramnoruth, Nishta, Patel, Swati, Hamilton-Williams, Emma E., Harris, Mark and Thomas, Ranjeny (2020). Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes. Frontiers in Immunology, 11 587469, 587469. doi: 10.3389/fimmu.2020.587469

A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes

Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Buckle, Irina and Hamilton-Williams, Emma E. (2020). A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes. Current Diabetes Reports, 20 (12) 70, 70. doi: 10.1007/s11892-020-01363-3

Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes

Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128

Early-life factors contributing to type 1 diabetes

Craig, Maria E., Kim, Ki Wook, Isaacs, Sonia R., Penno, Megan A., Hamilton-Williams, Emma E., Couper, Jennifer J. and Rawlinson, William D. (2019). Early-life factors contributing to type 1 diabetes. Diabetologia, 62 (10), 1823-1834. doi: 10.1007/s00125-019-4942-x

The gut microbiota in type 1 diabetes: friend or foe?

Gavin, Patrick G. and Hamilton-Williams, Emma E. (2019). The gut microbiota in type 1 diabetes: friend or foe?. Current Opinion in Endocrinology, Diabetes and Obesity, 26 (4), 207-212. doi: 10.1097/MED.0000000000000483

Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice

Mullaney, Jane A., Stephens, Juliette E., Geeling, Brooke E. and Hamilton-Williams, Emma E. (2018). Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice. Immunology and Cell Biology, 97 (1), 97-103. doi: 10.1111/imcb.12201

Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 Diabetes

Gavin, Patrick G., Mullaney, Jane A., Loo, Dorothy, Cao, Kim-Anh Lê, Gottlieb, Peter A., Hill, Michelle M., Zipris, Danny and Hamilton-Williams, Emma E. (2018). Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 Diabetes. Diabetes Care, 41 (10), 2178-2186. doi: 10.2337/dc18-0777

Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1), 51. doi: 10.1186/s40168-018-0438-z

A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes

Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018). A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 (5). doi: 10.1172/jci.insight.98212

Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1) 35, 1-16. doi: 10.1186/s40168-018-0417-4

CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes

Brenu, Ekua W., Bartley, Timothy J., Wright, Casey M. and Hamilton-Williams, Emma E. (2017). CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes. Immunology and Cell Biology, 95 (9), 803-813. doi: 10.1038/icb.2017.49

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

Reeves, Peta L. S., Rudraraju, Rajeev, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice. European Journal of Immunology, 47 (9), 1550-1561. doi: 10.1002/eji.201747089

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice

Reeves, Peta L. S., Rudraraju, Rajeev, Liu, Xiao, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. Immunology and Cell Biology, 95 (9), 765-774. doi: 10.1038/icb.2017.48

Maintenance of peripheral tolerance to islet antigens

Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice

James, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016). Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 (5), 509-519. doi: 10.1038/icb.2016.7

Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes

Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

Hamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A. and Wicker, Linda S. (2013). Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mammalian Genome, 24 (9-10), 358-375. doi: 10.1007/s00335-013-9466-y

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes

Lin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B., Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S. and Sherman, Linda A. (2013). Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. Journal of Immunology, 190 (7), 3109-3120. doi: 10.4049/jimmunol.1203422

PTPN22 alters the development of regulatory T cells in the thymus

Maine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S. and Sherman, Linda A. (2012). PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology, 188 (11), 5267-5275. doi: 10.4049/jimmunol.1200150

Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5

Hamilton-Williams, Emma E., Cheung, Jocelyn, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2012). Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes, 61 (1), 166-174. doi: 10.2337/db11-0790

Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice

Sheng, Huiming, Hassanali, Saleena, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma, Dias, Peter and Dai, Yang D. (2011). Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. Journal of Immunology, 187 (4), 1591-1600. doi: 10.4049/jimmunol.1100231

Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells

Hamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2010). Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells. Diabetes, 59 (6), 1478-1486. doi: 10.2337/db09-1801

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice

Hamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B., Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S. and Sherman, Linda A. (2009). Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. Journal of Immunology, 183 (3), 1533-1541. doi: 10.4049/jimmunol.0900428

Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (7), 2114-2114. doi: 10.1172/JCI38399C1

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (5), 1286-1297. doi: 10.1172/JCI38399

CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigens

Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gotot, Janine and Kurts, Christian (2009). CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigens. European Journal of Immunology, 39 (1), 225-233. doi: 10.1002/eji.200838699

Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens

Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Kurts, Christian (2008). Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. Journal of Immunology, 181 (7), 4447-4451. doi: 10.4049/jimmunol.181.7.4447

Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens

Benke, Dirk, Kruger, Thilo, Lang, Andreas, Hamilton-Williams, Emma E. and Kurts, Christian (2006). Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens. Journal of Immunological Methods, 310 (1-2), 12-19. doi: 10.1016/j.jim.2005.10.019

Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens

Hamilton-Williams, Emma E., Lang, Andreas, Benke, Dirk, Davey, Gayle M., Wiesmuller, Karl-Heinz and Kurts, Christian (2005). Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. Journal of Immunology, 174 (3), 1159-1163. doi: 10.4049/jimmunol.174.3.1159

Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal

Lang, Andreas, Benke, Dirk, Eitner, Frank, Engel, Daniel, Ehrlich, Svenja, Breloer, Minka, Hamilton-Williams, Emma, Specht, Sabine, Hoerauf, Achim, Floege, Jürgen, von Bonin, Arne and Kurts, Christian (2005). Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal. Journal of the American Society of Nephrology, 16 (2), 383-391. doi: 10.1681/ASN.2004040276

Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis

Kruger, T, Benke, D, Eitner, F, Lang, A, Wirtz, M, Hamilton-Williams, EE, Engel, D, Giese, B, Muller-Newen, G, Floege, J and Kurts, C (2004). Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. Journal of the American Society of Nephrology, 15 (3), 613-621. doi: 10.1097/01.ASN.0000114553.36258.91

Beta cell MHC class I is a late requirement for diabetes

Hamilton-Williams, EE, Palmer, SE, Charlton, B and Slattery, RM (2003). Beta cell MHC class I is a late requirement for diabetes. Proceedings of the National Academy of Sciences of the United States of America, 100 (11), 6688-6693. doi: 10.1073/pnas.1131954100

Development of new strategies to prevent type diabetes: the role of animal models

Hanninen, A, Hamilton-Williams, E and Kurts, C (2003). Development of new strategies to prevent type diabetes: the role of animal models. Annals of Medicine, 35 (8), 546-563. doi: 10.1080/07853890310014597

Acute reversible renal failure in acute generalized exanthematous pustulosis

Brandenburg, VM, Kurts, C, Eitner, F, Hamilton-Williams, E and Heintz, B (2002). Acute reversible renal failure in acute generalized exanthematous pustulosis. Nephrology Dialysis Transplantation, 17 (10), 1857-1858. doi: 10.1093/ndt/17.10.1857

Transgenic rescue implicates beta(2)-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice

Hamilton-Williams, EE, Serreze, DV, Charlton, B, Johnson, EA, Marron, MP, Mullbacher, A and Slattery, RM (2001). Transgenic rescue implicates beta(2)-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proceedings of the National Academy of Sciences of the United States of America, 98 (20), 11533-11538. doi: 10.1073/pnas.191383798

Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice

Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018. Hoboken, NJ, United States: Wiley. doi: 10.1002/eji.201871000

Antigen specific immunotherapy for autoimmune disease targeting dendritic cells

Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, 29 October - 2 November 2017. London United Kingdom: Elsevier.

Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice

Buckle, I, Steptoe, R. J., Thomas, R. and Hamilton-Williams, E. E. (2016). Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice. International Congress of Immunology (ICI 2016), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Type 1 diabetes susceptibility genes impair gut physiology and lead to perturbations in the microbiota

Mullaney, J., Stephens, J. and Hamilton-Williams, E. (2016). Type 1 diabetes susceptibility genes impair gut physiology and lead to perturbations in the microbiota. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200

Exosome-like microparticles can stimulate both innate and adaptive autoimmunity in non-obese diabetes mice

Dai, Yang, Sheng, Huiming, Hassanali, Saleema, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma and Dias, Peter (2011). Exosome-like microparticles can stimulate both innate and adaptive autoimmunity in non-obese diabetes mice. AMER ASSOC IMMUNOLOGISTS.

Antigen-specific suppression of non-lymphoid tissue auto-antibody production by CD25(+) FoxP3(+) regulatory T cells

Kurts, Christian, Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Gotot, Janine (2009). Antigen-specific suppression of non-lymphoid tissue auto-antibody production by CD25(+) FoxP3(+) regulatory T cells. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Expression of the Diabetes Associated Alleles of ldd3 and ldd5 in DCs Drives Loss of Tolerance in NOD Mice

Hamilton-Williams, Emma E., Martinez, Xavier, Hunter, Kara M., Rainbow, Dan, Wicker, Linda S. and Sherman, Linda A. (2009). Expression of the Diabetes Associated Alleles of ldd3 and ldd5 in DCs Drives Loss of Tolerance in NOD Mice. 9th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, San Francisco Ca, Jun 11-14, 2009. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. doi: 10.1016/j.clim.2009.03.270

CD8 T cells specific for a glomerular antigen induce renal inflammation in a CD4 help dependent fashion and may cause progressing Glomerulonephritis

Heymann, F., Hamilton-Williams, E. E., Ludwig-Portugall, I., Quaggin, S., Floege, J., Groene, H. and Kurts, C. (2008). CD8 T cells specific for a glomerular antigen induce renal inflammation in a CD4 help dependent fashion and may cause progressing Glomerulonephritis. SPRINGER WIEN.

Restoration of CD8 self-tolerance in NOD mice by protective Idd9 genes

Hamilton-Williams, Emma, Martinez, Javier, Wong, Justin, Wicker, Linda and Sherman, Linda (2008). Restoration of CD8 self-tolerance in NOD mice by protective Idd9 genes. FEDERATION AMER SOC EXP BIOL.

The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen

Hamilton-Williams, E.E., Martinez, X., Lyman, M., Hunter, K., Wicker, L.S. and Sherman, L.A. (2007). The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen. Conference on How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis, San Francisco, CA, United States, 8-9 November 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1394.003

Release of heat shock protein 60 is an endogenous enhancer of nephrotoxic nephritis

Kurts, C, Lang, A, Kruger, T, Benke, D, Hamilton-Williams, E, Wirtz, M, Ehrlich, S, von Bonin, A, Assmann, K, Eitner, F and Floege, J (2003). Release of heat shock protein 60 is an endogenous enhancer of nephrotoxic nephritis. 36th Annual Meeting of the American-Society-of-Nephrology, San Diego California, Nov 12-17, 2003. LIPPINCOTT WILLIAMS & WILKINS.