The University of Queensland

Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma

Logan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2). doi: 10.1002/cmtd.202300036

RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo

Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia

Moles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262

Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic

Chu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

Gao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h

Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics

Ahmed, Salma E., Fletcher, Nicholas L., Prior, Amber R., Huda, Pie, Bell, Craig A. and Thurecht, Kristofer J. (2022). Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics. Polymer Chemistry, 13 (27), 4004-4017. doi: 10.1039/d2py00257d

Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416

Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation

Johansen, Nicolai Tidemand, Bonaccorsi, Marta, Bengtsen, Tone, Larsen, Andreas Haahr, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, Pie, Berndtsson, Jens, Darwish, Tamim, Yepuri, Nageshewar Rao, Martel, Anne, Pomorski, Thomas Günther, Bertarello, Andrea, Sansom, Mark, Rapp, Mikaela, Crehuet, Ramon, Schubeis, Tobias, Lindorff-Larsen, Kresten, Pintacuda, Guido and Arleth, Lise (2022). Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation. eLife, 11 e71887. doi: 10.7554/elife.71887

Clinical development of an anti-GPC-1 antibody for the treatment of cancer

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas, Campbell, Douglas, Thurecht, Kristofer J. and Walsh, Bradley (2022). Clinical development of an anti-GPC-1 antibody for the treatment of cancer. Expert Opinion on Biological Therapy, 22 (5), 603-613. doi: 10.1080/14712598.2022.2033204

Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering

Jensen, Grethe V., Rosenmejer, Katrine R., Huda, Pie and Arleth, Lise (2021). Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering. Molecular Pharmaceutics, 18 (9), 3272-3280. doi: 10.1021/acs.molpharmaceut.1c00164

Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin

Tieu, Terence, Wojnilowicz, Marcin, Huda, Pie, Thurecht, Kristofer J., Thissen, Helmut, Voelcker, Nicolas H. and Cifuentes-Rius, Anna (2020). Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin. Biomaterials Science, 9 (1), 133-147. doi: 10.1039/d0bm01335h

Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets

Niamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088

Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering

Midtgaard, Søren Roi, Darwish, Tamim A., Pedersen, Martin Cramer, Huda, Pie, Larsen, Andreas Haahr, Jensen, Grethe Vestergaard, Kynde, Søren Andreas Røssell, Skar-Gislinge, Nicholas, Nielsen, Agnieszka Janina Zygadlo, Olesen, Claus, Blaise, Mickael, Dorosz, Jerzy Józef, Thorsen, Thor Seneca, Venskutonytė, Raminta, Krintel, Christian, Møller, Jesper V., Frielinghaus, Henrich, Gilbert, Elliot Paul, Martel, Anne, Kastrup, Jette Sandholm, Jensen, Poul Erik, Nissen, Poul and Arleth, Lise (2018). Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering. FEBS Journal, 285 (2), 357-371. doi: 10.1111/febs.14345

PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice

Huda, Pie, Binderup, Tina, Pedersen, Martin Cramer, Midtgaard, Soren Roi, Elema, Dennis Ringkjobing, Kjaer, Andreas, Jensen, Mikael and Arleth, Lise (2015). PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice. PLoS One, 10 (7) e0129310. doi: 10.1371/journal.pone.0129310

Investigating the function of F-c-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting

Stevenson, Liz, Huda, Pie, Jeppesen, Anine, Laursen, Erik, Rowe, J. Alexandra, Craig, Alister, Streicher, Werner, Barfod, Lea and Hviid, Lars (2015). Investigating the function of F-c-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting. Cellular Microbiology, 17 (6), 819-831. doi: 10.1111/cmi.12403

Immuno-PET agents for targeting glioblastoma

Ghosh, S., Huda, P., Fletcher, N., Howard, C., Lu, Y., Campbell, D., Walsh, B. and Thurecht, K. (2022). Immuno-PET agents for targeting glioblastoma. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 52nd ASM, Brisbane, QLD, Australia, 13–15 May 2022. Richmond, VIC, Australia: John Wiley & Sons.

Combined SAXS and Microfludics for time-resolved structural studies of bimolecules

Arleth, Lise, Jensen, Grethe Vestergaard, Huda, Pie, Skou, Soren, Shang, Weifeng and Chakravarthy, Srinivas (2017). Combined SAXS and Microfludics for time-resolved structural studies of bimolecules. XXIV IUCr Congress, Hyderabad, India, 21-28 August 2018. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/S2053273317089641

SAXS analysis of membrane proteins reconstituted into nanodiscs

Jarva, Michael, Huda, Pie, Skar-Gislinge, Nicholas, Arleth, Lise and Tornroth-Horsefield, Susanna (2012). SAXS analysis of membrane proteins reconstituted into nanodiscs. XXII IUCr Congress, Madrid, Spain, 22-30 August 2011. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/S0108767312096948