The University of Queensland

In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate

Sonzini, Silvia, Caputo, Fanny, Mehn, Dora, Calzolai, Luigi, Even Borgos, Sven, Hyldbakk, Astrid, Treacher, Kevin, Li, Weimin, Jackman, Mark, Mahmoudi, Najet, Jayne Lawrence, M., Patterson, Claire, Owen, David, Ashford, Marianne and Akhtar, Nadim (2023). In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate. International Journal of Pharmaceutics, 637 122905, 1-14. doi: 10.1016/j.ijpharm.2023.122905

Subcutaneous delivery of a dendrimer-BH3 mimetic improves lymphatic uptake and survival in lymphoma

Feeney, Orlagh M., Ardipradja, Katie, Noi, Ka Fung, Mehta, Dharmini, De Rose, Robert, Yuen, Daniel, Johnston, Angus P.R., Kingston, Lee, Ericsson, Cecilia, Elmore, Charles S., Hufton, Richard, Owen, David J., Ashford, Marianne B. and Porter, Christopher J.H. (2022). Subcutaneous delivery of a dendrimer-BH3 mimetic improves lymphatic uptake and survival in lymphoma. Journal of Controlled Release, 348, 420-430. doi: 10.1016/j.jconrel.2022.05.041

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R. ... Ashford, Marianne B. (2021). Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Communications Biology, 4 (1) 112, 112. doi: 10.1038/s42003-020-01631-8

Reducing dendrimer generation and PEG chain length increases drug release and promotes anti-cancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a cathepsin-cleavable peptide linker

Mehta, Dharmini, Leong, Nathania, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J.H. and Kaminskas, Lisa M. (2018). Reducing dendrimer generation and PEG chain length increases drug release and promotes anti-cancer activity of PEGylated polylysine dendrimers conjugated with doxorubicin via a cathepsin-cleavable peptide linker. Molecular Pharmaceutics, 15 (10) acs.molpharmaceut.8b00581, 4568-4576. doi: 10.1021/acs.molpharmaceut.8b00581

Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats

Leong, Nathania J., Mehta, Dharmini, McLeod, Victoria M., Kelly, Brian D., Pathak, Rashmi, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2018). Doxorubicin conjugation and drug linker chemistry alter the intravenous and pulmonary pharmacokinetics of a PEGylated Generation 4 polylysine dendrimer in rats. Journal of Pharmaceutical Sciences, 107 (9), 2509-2513. doi: 10.1016/j.xphs.2018.05.013

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site

Ryan G.M., McLeod V.M., Mehta D., Kelly B.D., Stanislawski P.C., Owen D.J., Kaminskas L.M. and Porter C.J.H. (2017). Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (8), 2485-2494. doi: 10.1016/j.nano.2017.08.003

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, Shadabul, McLeod, Victoria M., Jones, Seth, Fung, Sandy, Whittaker, Michael, McIntosh, Michelle, Pouton, Colin, Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2017). Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics, 119, 408-418. doi: 10.1016/j.ejpb.2017.07.005

A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep

Ryan, Gemma M., Bischof, Robert J., Enkhbaatar, Perenlei, McLeod, Victoria M., Chan, Linda J., Jones, Seth A., Owen, David J., Porter, Christopher J. H. and Kaminskas, Lisa M. (2016). A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep. Pharmaceutical Research, 33 (2), 510-525. doi: 10.1007/s11095-015-1806-z

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

Kaminskas, Lisa M., McLeod, Victoria M., Ascher, David B., Ryan, Gemma M., Jones, Seth, Haynes, John M., Trevaskis, Natalie L., Chan, Linda J., Sloan, Erica K., Finnin, Benjamin A., Williamson, Mark, Velkov, Tony, Williams, Elizabeth D., Kelly, Brian D., Owen, David J. and Porter, Christopher J. H. (2015). Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular Pharmaceutics, 12 (2), 432-443. doi: 10.1021/mp500531e

Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy

Kaminskas, Lisa M., McLeod, Victoria M., Ryan, Gemma M., Kelly, Brian D., Haynes, John M., Williamson, Mark, Thienthong, Neeranat, Owen, David J. and Porter, Christopher J. H. (2014). Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy. Journal of Controlled Release, 183 (1), 18-26. doi: 10.1016/j.jconrel.2014.03.012

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

Ryan, Gemma M., Kaminskas, Lisa M., Bulitta, Juergen B., McIntosh, Michelle P., Owen, David J. and Porter, Christopher J. H. (2013). PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin. Journal of Controlled Release, 172 (1), 128-136. doi: 10.1016/j.jconrel.2013.08.004

Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent

Ryan, Gemma M., Kaminskas, Lisa M., Kelly, Brian D., Owen, David J., McIntosh, Michelle P. and Porter, Christopher J. H. (2013). Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent. Molecular Pharmaceutics, 10 (8), 2986-2995. doi: 10.1021/mp400091n

Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models

Kaminskas, Lisa M., McLeod, Victoria M., Kelly, Brian D., Cullinane, Carleen, Sberna, Gian, Williamson, Mark, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2012). Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models. Molecular Pharmaceutics, 9 (3), 422-432. doi: 10.1021/mp200522d

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems

Kaminskas, Lisa M., McLeod, Victoria M., Kelly, Brian D., Sberna, Gian, Boyd, Ben J., Williamson, Mark, Owen, David J. and Porter, Christopher J. H. (2012). A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems. Nanomedicine: Nanotechnology, Biology and Medicine, 8 (1), 103-111. doi: 10.1016/j.nano.2011.05.013

Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Owen, David J., Boyd, Ben J. and Porter, Christopher J. H. (2011). Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. Journal of Controlled Release, 152 (2), 241-248. doi: 10.1016/j.jconrel.2011.02.005

Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers

Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2011). Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Molecular Pharmaceutics, 8 (2), 338-349. doi: 10.1021/mp1001872

Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting

Owen, David and Barrett, Paul (2010). Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting. ONdrugDelivery (4), 21-24.

Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate

Koohang, Ali, Bailey, Jessica L., Coates, Robert M., Erickson, Hans K., Owen, David and Poulter, C. Dale (2010). Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. Journal of Organic Chemistry, 75 (14), 4769-4777. doi: 10.1021/jo100718z

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol

Adams, Tim E., Sous, Mariana El, Hawkins, Bill C., Hirner, Sebastian, Holloway, Georgina, Khoo, Mui Ling, Owen, David J., Paul Savage, G., Seammells, Peter J. and Rizzacasa, Mark A. (2009). Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol. Journal of the American Chemical Society, 131 (4), 1607-1616. doi: 10.1021/ja808402e

Total synthesis of (-)-episilvestrol and (-)-silvestrol

El Sous, Mariana, Khoo, Mui Ling, Holloway, Georgina, Owen, David, Scammells, Peter J. and Rizzacasa, Mark A. (2007). Total synthesis of (-)-episilvestrol and (-)-silvestrol. Angewandte Chemie - International Edition, 46 (41), 7835-7838. doi: 10.1002/anie.200702700

Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria

Davis, Chris B., Hartnell, Regan D., Madge, Paul D., Owen, David J., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria. Carbohydrate Research, 342 (12-13), 1773-1780. doi: 10.1016/j.carres.2007.04.027

Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents

Owen, David J., Davis, Chris B., Hartnell, Regan D., Madge, Paul D., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents. Bioorganic and Medicinal Chemistry Letters, 17 (8), 2274-2277. doi: 10.1016/j.bmcl.2007.01.068

Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes

Pei, Yazhong, Lilly, Michael J., Owen, David J., D'Souza, Lawrence J., Tang, Xiao-Qing, Yu, Jinghua, Nazarbaghi, Ramina, Hunter, Andrew, Anderson, Christen M., Glasco, Susan, Ede, Nicholas J., James, Ian W., Maitra, Uday, Chandrasekaran, S., Moos, Walter H. and Ghosh, Soumitra S. (2003). Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes. Journal of Organic Chemistry, 68 (1), 92-103. doi: 10.1021/jo020446t

A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)

Owen, David J., Thomson, Robin J. and Von Itzstein, Mark (2002). A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides). Carbohydrate Research, 337 (21-23), 2017-2022. doi: 10.1016/S0008-6215(02)00133-7

Synthesis of Functional <i>Ras</i> Lipoproteins and Fluorescent Derivatives

Kuhn, Karsten, Owen, David J., Bader, Benjamin, Wittinghofer, Alfred, Kuhlmann, Jürgen and Waldmann, Herbert (2001). Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives. Journal of the American Chemical Society, 123 (6), 1023-1035. doi: 10.1021/ja002723o

Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125

Blake, Patrick S, Taylor, David R, Crisp, Carol M, Mander, Lewis N and Owen, David J (2000). Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125. Phytochemistry, 55 (8), 887-890. doi: 10.1016/S0031-9422(00)00237-5

Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II

Thoma N.H., Iakovenko A., Owen D., Scheidig A.S., Waldmann H., Goody R.S. and Alexandrov K. (2000). Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II. Biochemistry, 39 (39), 12043-12052. doi: 10.1021/bi000835m

A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides

Owen, David J. and Von Itzstein, Mark (2000). A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides. Carbohydrate Research, 328 (3), 287-292. doi: 10.1016/S0008-6215(00)00110-5

Bioorganic synthesis of lipid-modified proteins for the study of signal transduction

Bader, Benjamin, Kuhn, Karsten, Owen, David J., Waldmann, Herbert, Wittinghofer, Alfred and Kuhlmann, Jürgen (2000). Bioorganic synthesis of lipid-modified proteins for the study of signal transduction. Nature, 403 (6766), 223-226. doi: 10.1038/35003249

Peptide conjugates as tools for the study of biological signal transduction

Eisele, Frank, Owen, David J. and Waldmann, Herbert (1999). Peptide conjugates as tools for the study of biological signal transduction. Bioorganic and Medicinal Chemistry, 7 (2), 193-224. doi: 10.1016/S0968-0896(98)00204-1

Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors

Koohang, Ali, Coates, Robert M., Owen, David and Poulter, C. Dale (1999). Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors. Journal of Organic Chemistry, 64 (1), 6-7. doi: 10.1021/jo981833z

Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells

Owen, DJ, Alexandrov, K, Rostkova, E, Scheidig, AJ, Goody, RS and Waldmann, H (1999). Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells. Angewandte Chemie-International Edition, 38 (4), 509-512. doi: 10.1002/(SICI)1521-3773(19990215)38:4<509::AID-ANIE509>3.3.CO;2-V

Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus

Nakayama, Massyoshi, Nishijima, Takaaki, Koshioka, Masaji, Yamane, Hisakazu, Owen, David J. and Mander, Lewis N. (1998). Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus. Phytochemistry, 48 (4), 587-593. doi: 10.1016/s0031-9422(98)00035-1

Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm

Owen, David J., Mander, Lewis N., Storey, John M.D., Huntley, Rachael P., Gaskin, Paul, Lenton, John R., Gage, Douglas A. and Zeevaart, Jan A.D. (1998). Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm. Phytochemistry, 47 (3), 331-337. doi: 10.1016/S0031-9422(97)00577-3

Synthesis of 12-hydroxy C20-gibberellins

Mander, Lewis N. and Owen, David J. (1997). Synthesis of 12-hydroxy C20-gibberellins. Tetrahedron, 53 (6), 2137-2162. doi: 10.1016/s0040-4020(96)01109-x

Identification of three C20-gibberellins: GA97 (2β-hydroxy-GA53), GA98 (2β-hydroxy-GA44) and GA99 (2β-hydroxy-GA19)

Mander, Lewis N., Owen, David J., Croker, Stephen J., Gaskin, Paul, Hedden, Peter, Lewis, Mervyn J., Talon, Manuel, Gage, Douglas A., Zeevaart, Jan A.D., Brenner, Mark L. and Sheng, Chuxing (1996). Identification of three C20-gibberellins: GA97 (2β-hydroxy-GA53), GA98 (2β-hydroxy-GA44) and GA99 (2β-hydroxy-GA19). Phytochemistry, 43 (1), 23-28. doi: 10.1016/0031-9422(96)00251-8

Synthesis and confirmation of structure of three 13,15β-dihydroxy C-20 gibberellins, GA100, GA101 and GA102, isolated from the seeds of Helianthus annuus L

Owen, David J., Mander, Lewis N., Gaskin, Paul and Macmillan, Jake (1996). Synthesis and confirmation of structure of three 13,15β-dihydroxy C-20 gibberellins, GA100, GA101 and GA102, isolated from the seeds of Helianthus annuus L. Phytochemistry, 42 (4), 921-925. doi: 10.1016/0031-9422(96)00045-3

Structure determination and synthesis of a new gibberellin, GA99, from spinach plants: 2β-hydroxy-GA19

Mander, Lewis N. and Owen, David J. (1996). Structure determination and synthesis of a new gibberellin, GA99, from spinach plants: 2β-hydroxy-GA19. Tetrahedron Letters, 37 (5), 723-726. doi: 10.1016/0040-4039(95)02252-X

Synthesis of gibberellin GA53 and its (17,17-D2)derivative

Mander, Lewis N., Owen, David J. and Twitchin, Bruce (1996). Synthesis of gibberellin GA53 and its (17,17-D2)derivative. Australian Journal of Chemistry, 49 (2), 249-253. doi: 10.1071/ch9960249

3-epi-GA63, antheridiogen in Anemia phyllitidis

Yamauchi, Tadayuki, Oyama, Naomi, Yamane, Hisakazu, Murofushi, Noboru, Schraudolf, Helmut, Owen, David and Mander, Lewis N. (1995). 3-epi-GA63, antheridiogen in Anemia phyllitidis. Phytochemistry, 38 (6), 1345-1348. doi: 10.1016/0031-9422(94)00834-G

2,5-Dithiacyclopentylideneketene and Ethenedithione, S=C=C=S, Generated by Flash Vacuum Pyrolysis

Wentrup C., Kambouris P., Evans R.A., Owen D., Macfarlane G., Chuche J., Pommelet J.C., Cheikh A.B., Plisnier M. and Flammang R. (1991). 2,5-Dithiacyclopentylideneketene and Ethenedithione, S=C=C=S, Generated by Flash Vacuum Pyrolysis. Journal of the American Chemical Society, 113 (8), 3130-3135. doi: 10.1021/ja00008a048

Dendrimer-drug conjugates

Owen, David James, Stanislsawski, Pauline, Giannis, Michael and Bernhard, Oliver (2020). Dendrimer-drug conjugates.

Macromolecules

Owen, David (2017). Macromolecules.