The University of Queensland

3D Printing for Novel Dosage Form Design

Krueger, Liam, Miles, Jared A. and Popat, Amirali (2023). 3D Printing for Novel Dosage Form Design. AAPS Introductions in the Pharmaceutical Sciences. (pp. 25-44) Cham: Springer International Publishing. doi: 10.1007/978-3-031-34119-9_2

Size, shape and surface charge considerations of orally delivered nanomedicines

Rewatkar, Prarthana, Kumeria, Tushar and Popat, Amirali (2020). Size, shape and surface charge considerations of orally delivered nanomedicines. Nanotechnology for oral drug delivery. (pp. 143-176) edited by João Pedro Martins and Hélder A. Santos. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-818038-9.00005-3

Luminescent porous silicon nanoparticles for continuous wave and time-gated photoluminescence imaging

Kumeria, Tushar, Qu, Zhi, Popat, Amirali, Altalhi, Tariq and Santos, Abel (2019). Luminescent porous silicon nanoparticles for continuous wave and time-gated photoluminescence imaging. Theranostics: methods and protocols. (pp. 185-198) New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9769-5_13

Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

Singh, Ravi Raj, Mondal, Indranil, Janjua, Taskeen, Popat, Amirali and Kulshreshtha, Ritu (2024). Engineered smart materials for RNA based molecular therapy to treat Glioblastoma. Bioactive Materials, 33, 396-423. doi: 10.1016/j.bioactmat.2023.11.007

Cannabidiol - help and hype in targeting mucosal diseases

Moniruzzaman, Md, Janjua, Taskeen Iqbal, Martin, Jennifer H., Begun, Jakob and Popat, Amirali (2024). Cannabidiol - help and hype in targeting mucosal diseases. Journal of Controlled Release, 365, 530-543. doi: 10.1016/j.jconrel.2023.11.010

Silica nanoparticles: a review of their safety and current strategies to overcome biological barriers

Janjua, Taskeen Iqbal, Cao, Yuxue, Kleitz, Freddy, Linden, Mika, Yu, Chengzhong and Popat, Amirali (2023). Silica nanoparticles: a review of their safety and current strategies to overcome biological barriers. Advanced Drug Delivery Reviews, 203 115115, 115115. doi: 10.1016/j.addr.2023.115115

Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model

Schmid, Roman, Volcic, Meta, Fischer, Stephan, Qu, Zhi, Barth, Holger, Popat, Amirali, Kirchhoff, Frank and Lindén, Mika (2023). Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Scientific Reports, 13 (1) 20175, 1-17. doi: 10.1038/s41598-023-47445-6

Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis

Bakshi, Shrishty, Pandey, Preeti, Mohammed, Yousuf, Wang, Joanna, Sailor, Michael J., Popat, Amirali, Parekh, Harendra S. and Kumeria, Tushar (2023). Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis. Journal of Controlled Release, 363, 452-463. doi: 10.1016/j.jconrel.2023.09.045

Silica nanoparticles for brain cancer

Feng, Yuran, Cao, Yuxue, Singh, Ravi, Janjua, Taskeen Iqbal and Popat, Amirali (2023). Silica nanoparticles for brain cancer. Expert Opinion on Drug Delivery, ahead-of-print (ahead-of-print), 1-19. doi: 10.1080/17425247.2023.2273830

Osteoimmune-modulating and BMP-2-eluting anodised 3D printed titanium for accelerated bone regeneration

Ali, Masood, He, Yan, Chang, Anna Sze Ni, Wu, Alice, Liu, Jingyu, Cao, Yuxue, Mohammad, Yousuf, Popat, Amirali, Walsh, Laurie, Ye, Qingsong, Xu, Chun and Kumeria, Tushar (2023). Osteoimmune-modulating and BMP-2-eluting anodised 3D printed titanium for accelerated bone regeneration. Journal of Materials Chemistry B, 12 (1), 97-111. doi: 10.1039/d3tb01029e

Clinical translation of metal–organic frameworks

Tyagi, Nisha, Wijesundara, Yalini H., Gassensmith, Jeremiah J. and Popat, Amirali (2023). Clinical translation of metal–organic frameworks. Nature Reviews Materials, 8 (11), 701-703. doi: 10.1038/s41578-023-00608-3

NANOMEDICINE AND GENE THERAPY TO TREAT GLIOBLASTOMA

Singh, Ravi, Popat, Amirali and Kulshreshtha, Ritu (2023). NANOMEDICINE AND GENE THERAPY TO TREAT GLIOBLASTOMA. IBRO Neuroscience Reports, 15, S646. doi: 10.1016/j.ibneur.2023.08.1290

Virus-like silica nanoparticles improve permeability of macromolecules across the blood–brain barrier in vitro

Feng, Yuran, Cao, Yuxue, Qu, Zhi, Janjua, Taskeen Iqbal and Popat, Amirali (2023). Virus-like silica nanoparticles improve permeability of macromolecules across the blood–brain barrier in vitro. Pharmaceutics, 15 (9) 2239, 2239. doi: 10.3390/pharmaceutics15092239

3D printing tablets for high-precision dose titration of caffeine

Krueger, Liam, Cao, Yuxue, Zheng, Zheng, Ward, Jason, Miles, Jared A. and Popat, Amirali (2023). 3D printing tablets for high-precision dose titration of caffeine. International Journal of Pharmaceutics, 642 123132, 1-9. doi: 10.1016/j.ijpharm.2023.123132

Clinical translation of extracellular vesicles

Ghodasara, Aayushi, Raza, Aun, Wolfram, Joy, Salomon, Carlos and Popat, Amirali (2023). Clinical translation of extracellular vesicles. Advanced Healthcare Materials, 12 (28) 2301010, e2301010. doi: 10.1002/adhm.202301010

Engineering nano-cellulose bio-composites to improve protein delivery for oral vaccination

Cao, Pei, Amiralian, Nasim, Wang, Jingjing, Sun, Bing, Popat, Amirali, Xie, Fengwei, Xu, Zhi Ping, Li, Yan and Li, Li (2023). Engineering nano-cellulose bio-composites to improve protein delivery for oral vaccination. Biomaterials Advances, 149 213400, 1-11. doi: 10.1016/j.bioadv.2023.213400

Influence of pore size and surface functionalization of mesoporous silica nanoparticles on the solubility and antioxidant activity of confined coenzyme Q10

Meka, Anand Kumar, Gopalakrishna, Akshatha, Iriarte-Mesa, Claudia, Rewatkar, Prarthana, Qu, Zhi, Wu, Xiaoxin, Cao, Yuxue, Prasadam, Indira, Janjua, Taskeen Iqbal, Kleitz, Freddy, Kumeria, Tushar and Popat, Amirali (2023). Influence of pore size and surface functionalization of mesoporous silica nanoparticles on the solubility and antioxidant activity of confined coenzyme Q10. Molecular Pharmaceutics, 20 (6), 2966-2977. doi: 10.1021/acs.molpharmaceut.3c00017

Virus-like silica nanoparticles enhance macromolecule permeation in vivo

Cao, Yuxue, Janjua, Taskeen Iqbal, Qu, Zhi, Draphoen, Bastian, Bai, Yunfan, Linden, Mika, Moniruzzaman, Md., Hasnain, Sumaira Z., Kumeria, Tushar and Popat, Amirali (2023). Virus-like silica nanoparticles enhance macromolecule permeation in vivo. Biomaterials Science, 11 (13), 4508-4521. doi: 10.1039/d3bm00137g

Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma

Janjua, Taskeen Iqbal, Cao, Yuxue, Ahmed-Cox, Aria, Raza, Aun, Moniruzzaman, Md, Akhter, Dewan Taslima, Fletcher, Nicholas L., Kavallaris, Maria, Thurecht, Kristofer J. and Popat, Amirali (2023). Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma. Journal of Controlled Release, 357, 161-174. doi: 10.1016/j.jconrel.2023.03.040

Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides

Alharthi, Sitah, Popat, Amirali, Ziora, Zyta Maria and Moyle, Peter Michael (2023). Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides. Molecules, 28 (5) 2114, 1-17. doi: 10.3390/molecules28052114

Spray nebulization enables polycaprolactone nanofiber production in a manner suitable for generation of scaffolds or direct deposition of nanofibers onto cells

McKenna, Eamonn, Futrega, Kathryn, Klein, Travis J, Altalhi, Tariq A., Popat, Amirali, Kumeria, Tushar and Doran, Michael Robert (2022). Spray nebulization enables polycaprolactone nanofiber production in a manner suitable for generation of scaffolds or direct deposition of nanofibers onto cells. Biofabrication, 15 (2) 025003, 1-12. doi: 10.1088/1758-5090/aca5b7

3D printing hybrid materials using fused deposition modelling for solid oral dosage forms

Krueger, Liam, Miles, Jared A. and Popat, Amirali (2022). 3D printing hybrid materials using fused deposition modelling for solid oral dosage forms. Journal of Controlled Release, 351, 444-455. doi: 10.1016/j.jconrel.2022.09.032

Nanobiomaterials to modulate natural killer cell responses for effective cancer immunotherapy

Raza, Aun, Rossi, Gustavo Rodrigues, Janjua, Taskeen Iqbal, Souza-Fonseca-Guimaraes, Fernando and Popat, Amirali (2022). Nanobiomaterials to modulate natural killer cell responses for effective cancer immunotherapy. Trends in Biotechnology, 41 (1), 77-92. doi: 10.1016/j.tibtech.2022.06.011

Ultra-bright green carbon dots with excitation-independent fluorescence for bioimaging

Singh, Amandeep, Qu, Zhi, Sharma, Astha, Singh, Mandeep, Tse, Brian, Ostrikov, Kostya, Popat, Amirali, Sonar, Prashant and Kumeria, Tushar (2022). Ultra-bright green carbon dots with excitation-independent fluorescence for bioimaging. Journal of Nanostructure in Chemistry, 13 (3), 1-11. doi: 10.1007/s40097-022-00501-5

Formulation and biological evaluation of mesoporous silica nanoparticles loaded with combinations of sortase A inhibitors and antimicrobial peptides

Alharthi, Sitah, Ziora, Zyta M., Janjua, Taskeen, Popat, Amirali and Moyle, Peter M. (2022). Formulation and biological evaluation of mesoporous silica nanoparticles loaded with combinations of sortase A inhibitors and antimicrobial peptides. Pharmaceutics, 14 (5) 986, 986. doi: 10.3390/pharmaceutics14050986

Nanomaterials: the new antimicrobial magic bullet

Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Falconer, James Robert and Blaskovich, Mark A. T. (2022). Nanomaterials: the new antimicrobial magic bullet. ACS Infectious Diseases, 8 (4), 693-712. doi: 10.1021/acsinfecdis.1c00660

Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole

Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Blaskovich, Mark A.T. and Falconer, James Robert (2022). Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole. International Journal of Pharmaceutics, 616 121487, 121487. doi: 10.1016/j.ijpharm.2022.121487

Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic

Raza, A., Kamato, D., Sime, F.B., Roberts, J.A., Popat, A., Falconer, J.R. and Kumeria, T. (2022). Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic. Materials Today Advances, 13 100210, 100210. doi: 10.1016/j.mtadv.2022.100210

3D printing: potential clinical applications for personalised solid dose medications

Krueger, Liam, Miles, Jared A., Steadman, Kathryn J., Kumeria, Tushar, Freeman, Christopher R. and Popat, Amirali (2022). 3D printing: potential clinical applications for personalised solid dose medications. Medical Journal of Australia, 216 (2), 64-67. doi: 10.5694/mja2.51381

Spray‐n‐Sense: sprayable nanofibers for on‐site chemical sensing

Bakshi, Shrishty, Snoswell, Aaron J., Kwok, Kei Yeung, Cheng, Lung Hei, Altalhi, Tariq A., Santos, Abel, Popat, Amirali and Kumeria, Tushar (2022). Spray‐n‐Sense: sprayable nanofibers for on‐site chemical sensing. Advanced Functional Materials, 32 (16) 2103496, 2103496. doi: 10.1002/adfm.202103496

Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis

Parekh, Khushali, Hariharan, Kartik, Qu, Zhi, Rewatkar, Prarthana, Cao, Yuxue, Moniruzzaman, Md., Pandey, Preeti, Popat, Amirali and Mehta, Tejal (2021). Tacrolimus encapsulated mesoporous silica nanoparticles embedded hydrogel for the treatment of atopic dermatitis. International Journal of Pharmaceutics, 608 121079, 121079. doi: 10.1016/j.ijpharm.2021.121079

Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22

Elshaer, Dana, Moniruzzaman, Md., Ong, Yi Theng, Qu, Zhi, Schreiber, Veronika, Begun, Jakob and Popat, Amirali (2021). Facile synthesis of dendrimer like mesoporous silica nanoparticles to enhance targeted delivery of interleukin-22. Biomaterials Science, 9 (22), 7402-7411. doi: 10.1039/d1bm01352a

Enhanced Mucosal Transport of Polysaccharide–Calcium Phosphate Nanocomposites for Oral Vaccination

Cao, Pei, Wang, Jingjing, Sun, Bing, Rewatkar, Prarthana, Popat, Amirali, Fu, Changkui, Peng, Hui, Xu, Zhi Ping and Li, Li (2021). Enhanced Mucosal Transport of Polysaccharide–Calcium Phosphate Nanocomposites for Oral Vaccination. ACS Applied Bio Materials, 4 (11) acsabm.1c00798, 7865-7878. doi: 10.1021/acsabm.1c00798

Clinical translation of silica nanoparticles

Janjua, Taskeen Iqbal, Cao, Yuxue, Yu, Chengzhong and Popat, Amirali (2021). Clinical translation of silica nanoparticles. Nature Reviews Materials, 6 (12), 1-3. doi: 10.1038/s41578-021-00385-x

Nanocarriers for oral delivery of biologics: small carriers for big payloads

Cao, Yuxue, Rewatkar, Prarthana, Wang, Ran, Hasnain, Sumaira Z., Popat, Amirali and Kumeria, Tushar (2021). Nanocarriers for oral delivery of biologics: small carriers for big payloads. Trends in Pharmacological Sciences, 42 (11), 957-972. doi: 10.1016/j.tips.2021.08.005

Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles

Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali and Blaskovich, Mark A.T. (2021). Mesoporous silica nanoparticles improve oral delivery of antitubercular bicyclic nitroimidazoles. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00807, 4196-4206. doi: 10.1021/acsbiomaterials.1c00807

Over the counter low-dose cannabidiol: a viewpoint from the ACRE Capacity Building Group

Hallinan, Christine Mary, Eden, Edward, Graham, Myfanwy, Greenwood, Lisa-Marie, Mills, Jessica, Popat, Amirali, Truong, Linda and Bonomo, Yvonne (2021). Over the counter low-dose cannabidiol: a viewpoint from the ACRE Capacity Building Group. Journal of Psychopharmacology, 36 (6) ARTN 02698811211035394, 2698811211035394-665. doi: 10.1177/02698811211035394

Extracellular vesicle nanoarchitectonics for novel drug delivery applications

Sharma, Shayna, Masud, Mostafa Kamal, Kaneti, Yusuf Valentino, Rewatkar, Prarthana, Koradia, Aayushi, Hossain, Md. Shahriar A., Yamauchi, Yusuke, Popat, Amirali and Salomon, Carlos (2021). Extracellular vesicle nanoarchitectonics for novel drug delivery applications. Small, 17 (42) 2102220, 1-22. doi: 10.1002/smll.202102220

Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery

Raza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042

pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery

Pujara, Naisarg, Giri, Rabina, Yau Wong, Kuan, Qu, Zhi, Rewatkar, Prarthana, Moniruzzaman, Md., Begun, Jakob, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2021). pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery. Journal of Colloid and Interface Science, 589, 45-55. doi: 10.1016/j.jcis.2020.12.054

Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process

Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w

Frontiers in the treatment of glioblastoma: past, present and emerging

Janjua, Taskeen Iqbal, Rewatkar, Prarthana, Ahmed-Cox, Aria, Saeed, Iqira, Mansfeld, Friederike M., Kulshreshtha, Ritu, Kumeria, Tushar, Ziegler, David S., Kavallaris, Maria, Mazzieri, Roberta and Popat, Amirali (2021). Frontiers in the treatment of glioblastoma: past, present and emerging. Advanced Drug Delivery Reviews, 171, 108-138. doi: 10.1016/j.addr.2021.01.012

PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery

Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280

Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution

Ndayishimiye, John, Popat, Amirali, Kumeria, Tushar, Blaskovich, Mark A.T. and Falconer, James Robert (2021). Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution. International Journal of Pharmaceutics, 596 120240, 120240. doi: 10.1016/j.ijpharm.2021.120240

Protein nanoparticles for enhanced oral delivery of coenzyme-Q10: in vitro and in silico studies

Banun, Vanessa Jane, Rewatkar, Prarthana, Chaudhary, Zanib, Qu, Zhi, Janjua, Taskeen, Patil, Anuja, Wu, Yuao, Ta, Hang T., Bansal, Nidhi, Miles, Jared A., Ross, Benjamin P., Kumeria, Tushar and Popat, Amirali (2021). Protein nanoparticles for enhanced oral delivery of coenzyme-Q10: in vitro and in silico studies. ACS Biomaterials Science and Engineering, 9 (6) acsbiomaterials.0c01354, 2846-2856. doi: 10.1021/acsbiomaterials.0c01354

Emerging nanomedicines for the treatment of atopic dermatitis

Parekh, Khushali, Mehta, Tejal A., Dhas, Namdev, Kumar, Pavan and Popat, Amirali (2021). Emerging nanomedicines for the treatment of atopic dermatitis. AAPS PharmSciTech, 22 (2) 55, 55. doi: 10.1208/s12249-021-01920-3

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284

Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin

Ndayishimiye, John, Cao, Yuxue, Kumeria, Tushar, Blaskovich, Mark A. T., Falconer, James Robert and Popat, Amirali (2021). Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin. Journal of Materials Chemistry B, 9 (35), 7145-7166. doi: 10.1039/d1tb01430g

Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma

Janjua, Taskeen Iqbal, Ahmed-Cox, Aria, Meka, Anand Kumar, Mansfeld, Friederike M., Forgham, Helen, Ignacio, Rosa Mistica C., Cao, Yuxue, McCarroll, Joshua A., Mazzieri, Roberta, Kavallaris, Maria and Popat, Amirali (2021). Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma. Nanoscale, 13 (40), 16909-16922. doi: 10.1039/d1nr03553c

Rapid fabrication of homogeneously distributed hyper-branched gold nanostructured electrode based electrochemical immunosensor for detection of protein biomarkers

Bakshi, Shrishty, Mehta, Samriddhi, Kumeria, Tushar, Shiddiky, Muhammad J.A., Popat, Amirali, Choudhury, Sangeeta, Bose, Sudeep and Nayak, Ranu (2021). Rapid fabrication of homogeneously distributed hyper-branched gold nanostructured electrode based electrochemical immunosensor for detection of protein biomarkers. Sensors and Actuators, B: Chemical, 326 128803, 128803. doi: 10.1016/j.snb.2020.128803

Oral meropenem for superbugs: challenges and opportunities

Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004

One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease

Qu, Zhi, Wong, Kuan Yau, Moniruzzaman, Md., Begun, Jakob, Santos, Hélder A, Hasnain, Sumaira Z., Kumeria, Tushar, McGuckin, Michael A. and Popat, Amirali (2020). One‐pot synthesis of pH‐responsive eudragit‐mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease. Advanced Therapeutics, 4 (2) 2000165, 2000165. doi: 10.1002/adtp.202000165

Silica nanoparticles: a promising platform for enhanced oral delivery of macromolecules

Abeer, Muhammad Mustafa, Rewatkar, Prarthana, Qu, Zhi, Talekar, Meghna, Kleitz, Freddy, Schmid, Roman, Lindén, Mika, Kumeria, Tushar and Popat, Amirali (2020). Silica nanoparticles: a promising platform for enhanced oral delivery of macromolecules. Journal of Controlled Release, 326, 544-555. doi: 10.1016/j.jconrel.2020.07.021

Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides

Ndayishimiye, John, Popat, Amirali, Blaskovich, Mark and Falconer, James Robert (2020). Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides. Journal of Controlled Release, 324, 728-749. doi: 10.1016/j.jconrel.2020.05.002

Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: In vitro release, cytotoxicity and mitochondrial activity

Juère, Estelle, Del Favero, Giorgia, Masse, Florence, Marko, Doris, Popat, Amirali, Florek, Justyna, Caillard, Romain and Kleitz, Freddy (2020). Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: In vitro release, cytotoxicity and mitochondrial activity. European Journal of Pharmaceutics and Biopharmaceutics, 151, 171-180. doi: 10.1016/j.ejpb.2020.03.015

Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis

Pujara, Naisarg, Wong, Kuan Yau, Qu, Zhi, Wang, Ran, Moniruzzaman, Md., Rewatkar, Prarthana, Kumeria, Tushar, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2020). Oral delivery of β-lactoglobulin nanospheres encapsulated resveratrol alleviates inflammation in Winnie mice with spontaneous ulcerative colitis. Molecular Pharmaceutics, 18 (2) acs.molpharmaceut.0c00048, 627-640. doi: 10.1021/acs.molpharmaceut.0c00048

The solid progress of nanomedicine

Martins, João Pedro, das Neves, José, de la Fuente, María, Celia, Christian, Florindo, Helena, Günday-Türeli, Nazende, Popat, Amirali, Santos, José Luis, Sousa, Flávia, Schmid, Ruth, Wolfram, Joy, Sarmento, Bruno and Santos, Hélder A. (2020). The solid progress of nanomedicine. Drug Delivery and Translational Research, 10 (3), 726-729. doi: 10.1007/s13346-020-00743-2

Polymer-mesoporous silica nanoparticle core-shell nanofibers as a dual-drug-delivery system for guided tissue regeneration

Xu, Chun, Cao, Yuxue, Lei, Chang, Li, Zhihao, Kumeria, Tushar, Meka, Anand Kumar, Xu, Jia, Liu, Jingyu, Yan, Cheng, Luo, Lihua, Khademhosseini, Ali, Popat, Amirali, He, Yan and Ye, Qingsong (2020). Polymer-mesoporous silica nanoparticle core-shell nanofibers as a dual-drug-delivery system for guided tissue regeneration. ACS Applied Nano Materials, 3 (2), 1457-1467. doi: 10.1021/acsanm.9b02298

Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles

Chaudhary, Zanib, Khan, Gul Majid, Abeer, Muhammad Mustafa, Pujara, Naisarg, Wan-Chi Tse, Brian, McGuckin, Michael A., Popat, Amirali and Kumeria, Tushar (2019). Efficient photoacoustic imaging using indocyanine green (ICG) loaded functionalized mesoporous silica nanoparticles. Biomaterials Science, 7 (12), 5002-5015. doi: 10.1039/c9bm00822e

Encapsulation and controlled release of Resveratrol within functionalized mesoporous silica nanoparticles for prostate cancer therapy

Chaudhary, Zanib, Subramaniam, Sugarniya, Khan, Gul Majid, Abeer, Muhammad Mustafa, Qu, Zhi, Janjua, Taskeen, Kumeria, Tushar, Batra, Jyotsna and Popat, Amirali (2019). Encapsulation and controlled release of Resveratrol within functionalized mesoporous silica nanoparticles for prostate cancer therapy. Frontiers in Bioengineering and Biotechnology, 7 225, 225. doi: 10.3389/fbioe.2019.00225

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

Rationally designed dendritic silica nanoparticles for oral delivery of exenatide

Abeer, Muhammad Mustafa, Meka, Anand Kumar, Pujara, Naisarg, Kumeria, Tushar, Strounina, Ekaterina, Nunes, Rute, Costa, Ana, Sarmento, Bruno, Hasnain, Sumaira Z., Ross, Benjamin P. and Popat, Amirali (2019). Rationally designed dendritic silica nanoparticles for oral delivery of exenatide. Pharmaceutics, 11 (8) 418, 418. doi: 10.3390/pharmaceutics11080418

Succinylated β-lactoglobuline-functionalized multiwalled carbon nanotubes with improved colloidal stability and biocompatibility

Jain, Sanyog, Dongave, Shesherao M., Date, Tushar, Kushwah, Varun, Mahajan, Rahul R., Pujara, Naisarg, Kumeria, Tushar and Popat, Amirali (2019). Succinylated β-lactoglobuline-functionalized multiwalled carbon nanotubes with improved colloidal stability and biocompatibility. ACS Biomaterials Science and Engineering, 5 (7) acsbiomaterials.9b00268, 3361-3372. doi: 10.1021/acsbiomaterials.9b00268

Treatment of atherosclerotic plaque: perspectives on theranostics

Zhang, Yicong, Koradia, Aayushi, Kamato, Danielle, Popat, Amirali, Little, Peter J. and Ta, Hang T. (2019). Treatment of atherosclerotic plaque: perspectives on theranostics. Journal of Pharmacy and Pharmacology, 71 (7) jphp.13092, 1029-1043. doi: 10.1111/jphp.13092

Environmental copper sensor based on polyethylenimine-functionalized nanoporous anodic alumina interferometers

Kaur, Simarpreet, Law, Cheryl Suwen, Williamson, Nathan Hu, Kempson, Ivan, Popat, Amirali, Kumeria, Tushar and Santos, Abel (2019). Environmental copper sensor based on polyethylenimine-functionalized nanoporous anodic alumina interferometers. Analytical Chemistry, 91 (8) acs.analchem.8b04963, 5011-5020. doi: 10.1021/acs.analchem.8b04963

Enhanced solubility, permeability and anticancer activity of vorinostat using tailored mesoporous silica nanoparticles

Meka, Anand, Jenkins, Laura, Dàvalos-Salas, Mercedes, Pujara, Naisarg, Wong, Kuan, Kumeria, Tushar, Mariadason, John and Popat, Amirali (2018). Enhanced solubility, permeability and anticancer activity of vorinostat using tailored mesoporous silica nanoparticles. Pharmaceutics, 10 (4) 283, 283. doi: 10.3390/pharmaceutics10040283

ε-Poly-l-Lysine/plasmid DNA nanoplexes for efficient gene delivery in vivo

Mandal, Haimanti, Katiyar, Sameer S, Swami, Rajan, Kushwah, Varun, Katare, Parmeshwar B, Kumar Meka, Anand, Banerjee, Sanjay K, Popat, Amirali and Jain, Sanyog (2018). ε-Poly-l-Lysine/plasmid DNA nanoplexes for efficient gene delivery in vivo. International Journal of Pharmaceutics, 542 (1-2), 142-152. doi: 10.1016/j.ijpharm.2018.03.021

A well-tolerated and rapidly acting thiopurine for IBD?

Florin, Timothy H. J., Wright, John D., Jambhrunkar, Siddharth D., Henman, Michael G. and Popat, Amirali (2018). A well-tolerated and rapidly acting thiopurine for IBD?. Drug Discovery Today, 24 (1), 37-41. doi: 10.1016/j.drudis.2018.09.001

In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles

Juere, Estelle, Florek, Justyna, Bouchoucha, Meryem, Jambhnukar, Siddharth, Wong, Kuan Yau, Popat, Amirali and Kleitz, Freddy (2017). In vitro dissolution, cellular membrane permeability and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles. Molecular Pharmaceutics, 14 (12), 4431-4441. doi: 10.1021/acs.molpharmaceut.7b00529

Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina

Thakur, Sachin S., Ward, Micheal S., Popat, Amirali, Flemming, Nicole B., Parat, Marie-Odile, Barnett, Nigel L. and Parekh, Harendra S. (2017). Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina. Plos One, 12 (5) e0178305, e0178305. doi: 10.1371/journal.pone.0178305

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411

Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles

Tyagi, Nisha, De, Ranjit, Begun, Jakob and Popat, Amirali (2017). Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles. International Journal of Pharmaceutics, 518 (1-2), 220-227. doi: 10.1016/j.ijpharm.2016.12.030

Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate

Pujara, Naisarg, Jambhrunkar, Siddharth, Wong, Kuan Yau, McGuckin, Michael and Popat, Amirali (2017). Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate. Journal of Colloid and Interface Science, 488, 303-308. doi: 10.1016/j.jcis.2016.11.015

GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses

Lee, Edward C., Davis-Poynter, Nicholas, Nguyen, Chau T. H., Peters, Amelia A., Monteith, Gregory R., Strounina, Ekaterina, Popat, Amirali and Ross, Benjamin P. (2016). GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses. Nanoscale, 8 (36), 16192-16196. doi: 10.1039/c6nr03878f

Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol

Summerlin, Natalie, Qu, Zhi, Pujara, Naisarg, Sheng, Yong, Jambhrunkar, Siddharth, McGuckin, Michael and Popat, Amirali (2016). Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol. Colloids and Surfaces B: Biointerfaces, 144 (4), 1-7. doi: 10.1016/j.colsurfb.2016.03.076

Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach

Soo, Ernest, Thakur, Sachin, Qu, Zhi, Jambhrunkar, Siddharth, Parekh, Harebdra S. and Popat, Amirali (2016). Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach. Journal of Colloid and Interface Science, 462, 368-374. doi: 10.1016/j.jcis.2015.10.022

Resveratrol nanoformulations: challenges and opportunities

Summerlin, Natalie, Soo, Ernest, Thakur, Sachin, Qu, Zhi, Jambhrunkar, Siddharth and Popat, Amirali (2015). Resveratrol nanoformulations: challenges and opportunities. International Journal of Pharmaceutics, 479 (2), 282-290. doi: 10.1016/j.ijpharm.2015.01.003

Floating tablets from mesoporous silica nanoparticles

Abbaraju, Prasanna Lakshmi, Meka, Anand kumar, Jambhrunkar, Siddharth, Zhang, Jun, Xu, Chun, Popat, Amirali and Yu, Chengzhong (2014). Floating tablets from mesoporous silica nanoparticles. Journal of Materials Chemistry B, 2 (47), 8298-8302. doi: 10.1039/c4tb01337a

Silica vesicles as nanocarriers and adjuvants for generating both antibody and T-cell mediated immune resposes to Bovine Viral Diarrhoea Virus E2 protein

Mody, Karishma T., Mahony, Donna, Zhang, Jun, Cavallaro, Antonino S., Zhang, Bing, Popat, Amirali, Mahony, Timothy J., Yu, Chengzhong and Mitter, Neena (2014). Silica vesicles as nanocarriers and adjuvants for generating both antibody and T-cell mediated immune resposes to Bovine Viral Diarrhoea Virus E2 protein. Biomaterials, 35 (37), 9972-9983. doi: 10.1016/j.biomaterials.2014.08.044

Nanodispersed UV blockers in skin-friendly silica vesicles with superior UV-attenuating efficiency

Zhang, Jun, Raphael, Anthony P., Yang, Yannan, Popat, Amirali, Prow, Tarl W. and Yu, Chengzhong (2014). Nanodispersed UV blockers in skin-friendly silica vesicles with superior UV-attenuating efficiency. Journal of Materials Chemistry B, 2 (44), 7673-7678. doi: 10.1039/c4tb01332h

Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles

Jambhrunkar, Siddharth, Qu, Zhi, Popat, Amirali, Karmakar, Surajit, Xu, Chun and Yu, Chengzhong (2014). Modulating in vitro release and solubility of griseofulvin using functionalized mesoporous silica nanoparticles. Journal of Colloid and Interface Science, 434, 218-225. doi: 10.1016/j.jcis.2014.08.019

Effect of surface functionality of silica nanoparticles on cellular uptake and cytotoxicity

Jambhrunkar, Siddharth, Qu, Zhi, Popat, Amirali, Yang, Jie, Noonan, Owen, Acauan, Luiz, Ahmad Nor, Yusilawati, Yu, Chengzhong and Karmakar, Surajit (2014). Effect of surface functionality of silica nanoparticles on cellular uptake and cytotoxicity. Molecular Pharmaceutics, 11 (10), 3642-3655. doi: 10.1021/mp500385n

Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity

Popat, Amirali, Karmakar, Surajit, Jambhrunkar, Siddharth, Xu, Chun and Yu, Chengzhong (2014). Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and Surfaces B: Biointerfaces, 117, 520-527. doi: 10.1016/j.colsurfb.2014.03.005

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Popat, Amirali, Jambhrunkar, Siddharth, Zhang, Jun, Yang, Jie, Zhang, Honwei, Meka, Anand and Yu, Chengzhong (2014). Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery. Chemical Communications, 50 (42), 5547-5550. doi: 10.1039/C4CC00620H

Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery

Xu, Chun, Niu, Yuting, Popat, Amirali, Jambhrunkar, Siddharth, Karmakar, Surajit and Yu, Chengzhong (2014). Rod-like mesoporous silica nanoparticles with rough surfaces for enhanced cellular delivery. Journal of Materials Chemistry B, 2 (3), 253-256. doi: 10.1039/c3tb21431a

An overview of recent patents on nanosuspension

Modh, Nirav, Mehta, Dharmik, Parejiya, Punit, Popat, Amirali and Barot, Bhavesh (2014). An overview of recent patents on nanosuspension. Recent Patents on Drug Delivery and Formulation, 8 (2), 144-154. doi: 10.2174/1872211308666140422150819

Mesoporous silica nanoparticles enhance the cytotoxicity of curcumin

Jambhrunkar, Siddharth, Karmakar, Surajit, Popat, Amirali, Yu, Meihua and Yu, Chengzhong (2014). Mesoporous silica nanoparticles enhance the cytotoxicity of curcumin. RSC Advances, 4 (2), 709-712. doi: 10.1039/c3ra44257h

Synthesis of silica vesicles with small sizes and reduced aggregation for photodynamic therapy

Yang, Yannan, Karmakar, Surajit, Yu, Meihua, Popat, Amirali and Yu, Chengzhong (2014). Synthesis of silica vesicles with small sizes and reduced aggregation for photodynamic therapy. Chemistry Letters, Article in press (3), 316-318. doi: 10.1246/cl.130930

Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery

Mody, Karishma T., Popat, Amirali, Mahony, Donna, Cavallaro, Antonino S., Yu, Chengzhong and Mitter, Neena (2013). Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery. Nanoscale, 5 (12), 5167-5179. doi: 10.1039/c3nr00357d

pH-Responsive Nutraceutical-Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability

Guillet-Nicolas, Rémy, Popat, Amirali, Bridot, Jean-Luc, Monteith, Gregory, Qiao, Shi Zhang and Kleitz, Freddy (2013). pH-Responsive Nutraceutical-Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability. Angewandte Chemie, 125 (8), 2374-2378. doi: 10.1002/ange.201208840

pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability

Guillet-Nicolas, Remy, Popat, Amirali, Bridot, Jean-Luc, Monteith, Gregory, Qiao, Shi Zhang and Kleitz, Freddy (2013). pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability. Angewandte Chemie International Edition, 52 (8), 2318-2322. doi: 10.1002/anie.201208840

Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres

Popat, Amirali, Ross, Benjamin P., Liu, Jian, Jambhrunkar, Siddharth, Kleitz, Freddy and Qiao, Shi Zhang (2012). Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres. Angewandte Chemie International, 51 (50), 12486-12489. doi: 10.1002/anie.201206416

Recent advance in silica-based engineered nanoparticles for gene therapy

Niu, Yuting, Popat, Amirali, Yu, Meihua, Karmakar, Surajit, Gu, Wenyi and Yu, Chengzhong (2012). Recent advance in silica-based engineered nanoparticles for gene therapy. Therapeutic Delivery, 3 (10), 1217-1237. doi: 10.4155/tde.12.98

A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles

Popat, Amirali, Liu, Jian, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012). A pH-responsive drug delivery system based on chitosan coated mesoporous silica nanoparticles. Journal of Materials Chemistry, 22 (22), 11173-11178. doi: 10.1039/c2jm30501a

Adsorption and release of biocides with mesoporous silica nanoparticles

Popat, Amirali, Liu, Jian, Hu, Qiuhong, Kennedy, Michael, Peters, Brenton, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012). Adsorption and release of biocides with mesoporous silica nanoparticles. Nanoscale, 4 (3), 970-975. doi: 10.1039/c2nr11691j

Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

Popat, Amirali, Hartono, Sandy Budi, Stahr, Frances, Liu, Jian, Qiao, Shi Zhang and Lu, Gao Qing (Max) (2011). Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale, 3 (7), 2801-2818. doi: 10.1039/c1nr10224a

Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease

Moniruzzaman, M., Rewatkar, P., Begun, J. and Popat, A. (2023). Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease. 18th Congress of ECCO, Copenhagen, Denmark, 1-4 March 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjac190.0167

Extended-release formulations comprising 6-thioguanine 

Florin, Timothy, Popat, Amirali and Jambhrunkar, Siddharth (2023). Extended-release formulations comprising 6-thioguanine . CA3038602C.

Novel formulation and treatment methods

Florin, Timothy, Popat, Amirali and Jambhrunkar, Siddharth (2021). Novel formulation and treatment methods. US20210393638A1.

Formulation and treatment methods

Florin, Timothy, Popat, Amirali and Jambhrunkar, Siddharth (2021). Formulation and treatment methods. US11077112B2.

Porous Silica Nanoparticles for Targeted and Controlled Release of Biomolecules

Amirali Popat (2012). Porous Silica Nanoparticles for Targeted and Controlled Release of Biomolecules. PhD Thesis, Aust Institute for Bioengineering & Nanotechnology, The University of Queensland.

Controlled release particles and method for preparation thereof

Lu, Gao Qing, Qiao, Shizhang and Popat, Amirali Akbarbhai (2011). Controlled release particles and method for preparation thereof. WO2011054046A1.