The University of Queensland

Theranostic nanoparticles for imaging and targeted drug delivery to the liver

Wang, Haolu, Yang, Haotian, Ruan, Qi, Roberts, Michael S. and Liang, Xiaowen (2022). Theranostic nanoparticles for imaging and targeted drug delivery to the liver. Fundamentals of drug delivery. (pp. 311-328) edited by Heather A. E. Benson, Michael S. Roberts, Adrian C. Williams and Xiaowen Liang. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119769644.ch12

Revealing interaction of dyes and nanomaterials by multiphoton imaging

Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020

Hepatic metabolism in liver health and disease

Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8

Artificial cells for the treatment of liver diseases

Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012

C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation

Zhang, Yonglong, Wang, Hui, Chen, Tao, Wang, Haolu, Liang, Xiaowen, Zhang, Yuchen, Duan, Jinlin, Qian, Shenjiao, Qiao, Ke, Zhang, Lei, Liu, Yanfeng and Wang, Jian (2021). C24‐ceramide drives gallbladder cancer progression through directly targeting phosphatidylinositol 5‐phosphate 4‐kinase type‐2 gamma to facilitate mammalian target of rapamycin signaling activation. Hepatology, 73 (2), 692-712. doi: 10.1002/hep.31304

Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse

Yang, Jingxing, Hou, Mengfei, Sun, Wenshe, Wu, Qinghe, Xu, Jia, Xiong, Liqin, Chai, Yimin, Liu, Yuxin, Yu, Meihua, Wang, Haolu, Xu, Zhi Ping, Liang, Xiaowen and Zhang, Chunfu (2020). Sequential PDT and PTT using dual-modal single-walled carbon nanohorns synergistically promote systemic immune responses against tumor metastasis and relapse. Advanced Science, 7 (16) 2001088, 2001088. doi: 10.1002/advs.202001088

Hepatic artery classification based on three-dimensional CT

Yan, J., Feng, H., Wang, H., Yuan, F., Yang, C., Liang, X., Chen, W. and Wang, J. (2020). Hepatic artery classification based on three-dimensional CT. British Journal of Surgery, 107 (7), 906-916. doi: 10.1002/bjs.11458

Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma

Ruan, Qi, Wang, Haolu, Burke, Leslie J., Bridle, Kim R., Li, Xinxing, Zhao, Chun-Xia, Crawford, Darrell H. G., Roberts, Michael S. and Liang, Xiaowen (2020). Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma. International Journal of Cancer, 147 (6) ijc.32899, 1519-1527. doi: 10.1002/ijc.32899

A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications

He, Haihong, Liu, Yuxin, Zhou, Zhongneng, Guo, Chunlei, Wang, Hong-Yin, Wang, Zhuang, Wang, Xueli, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A photo-triggered and photo-calibrated nitric oxide donor: rational design, spectral characterizations, and biological applications. Free Radical Biology and Medicine, 123, 1-7. doi: 10.1016/j.freeradbiomed.2018.04.563

Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells

Luo, Xiao, Yang, Haotian, Wang, Haolu, Ye, Zhiwei, Zhou, Zhongneng, Gu, Luyan, Chen, Jinquan, Xiao, Yi, Liang, Xiaowen, Qian, Xuhong and Yang, Youjun (2018). Highly sensitive hill-type small-molecule pH probe that recognizes the reversed pH gradient of cancer cells. Analytical Chemistry, 90 (9), 5803-5809. doi: 10.1021/acs.analchem.8b00218

A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications

He, Haihong, Xia, Yang, Qi, Yingxue, Wang, Hong-Yin, Wang, Zhuang, Bao, Jianming, Zhang, Ziqian, Wu, Fu-Gen, Wang, Haolu, Chen, Daijie, Yang, Dahai, Liang, Xiaowen, Chen, Jinquan, Zhou, Shengmin, Liang, Xin, Qian, Xuhong and Yang, Youjun (2018). A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry, 29 (4), 1194-1198. doi: 10.1021/acs.bioconjchem.7b00821

Indocyanine green-incorporating nanoparticles for cancer theranostics

Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39

TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT

Li, Xinxing, Teng, Shifeng, Zhang, Yanyan, Zhang, Weigang, Zhang, Xianwen, Xu, Kai, Yao, Houshan, Yao, Jun, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017). TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. OncoTarget, 8 (29), 47052-47063. doi: 10.18632/oncotarget.16789

Multiphoton imaging for assessing renal disposition in acute kidney injury

Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374, 45374. doi: 10.1038/srep45374

A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury

Zhang, Feiyue, Liang, Xiaowen, Zhang, Wenzhu, Wang, Yong-Lei, Wang, Haolu, Mohammed, Yousuf H., Song, Bo, Zhang, Run and Yuan, Jingli (2017). A unique iridium(III) complex-based chemosensor for multi-signal detection and multi-channel imaging of hypochlorous acid in liver injury. Biosensors and Bioelectronics, 87, 1005-1011. doi: 10.1016/j.bios.2016.09.067

MDCT assessment of resectability in hilar cholangiocarcinoma

Ni, Qihong, Wang, Haolu, Zhang, Yunhe, Qian, Lijun, Chi, Jiachang, Liang, Xiaowen, Chen, Tao and Wang, Jian (2016). MDCT assessment of resectability in hilar cholangiocarcinoma. Abdominal Radiology, 42 (3), 1-10. doi: 10.1007/s00261-016-0943-0

Late-onset deep mesh infection: a study of eight cases detected from 2666 consecutive patients with abdominal wall hernia repairs

Chen, Tao, Zhang, Yun-He, Wang, Hao-Lu, Chen, Wei and Wang, Jian (2016). Late-onset deep mesh infection: a study of eight cases detected from 2666 consecutive patients with abdominal wall hernia repairs. Chinese Medical Journal, 129 (15), 1870-1872. doi: 10.4103/0366-6999.186651

Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy

Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083

Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

Macklin, Rebecca, Wang, Haolu, Loo, Dorothy, Martin, Sally, Cumming, Andrew, Cai, Na, Lane, Rebecca, Ponce, Natalia Saenz, Topkas, Eleni, Inder, Kerry, Saunders, Nicholas A. and Endo-Munoz, Liliana (2016). Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones. Oncotarget, 7 (28), 43570-43587. doi: 10.18632/oncotarget.9781

Emergency inguinal hernia repair under local anesthesia: a 5-year experience in a teaching hospital

Chen, Tao, Zhang, Yunhe, Wang, Haolu, Ni, Qihong, Yang, Linhua, Li, Qiwei and Wang, Jian (2016). Emergency inguinal hernia repair under local anesthesia: a 5-year experience in a teaching hospital. BMC Anesthesiology, 16 (1) 17, 17-17. doi: 10.1186/s12871-016-0185-2

A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells

Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293

Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles

Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854

Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney

Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066

Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects

Jin, Yue, Wang, Haolu, Ma, Xiaowei, Liang, Xiaowen, Liu, Xin and Wang, Yu (2015). Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects. PLoS ONE, 10 (5) e0127229, e0127229. doi: 10.1371/journal.pone.0127229

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging

Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D

Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition

Thorling C.A., Jin L., Weiss M., Crawford D., Liu X., Burczynski F.J., Liu D., Wang H. and Roberts M.S. (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug Metabolism and Disposition, 43 (1), 154-162. doi: 10.1124/dmd.114.060848

Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis

Jin, Yue, Wang, Haolu, Liang, Xiaowen, Ma, Jun and Wang, Yu (2014). Pathological and prognostic significance of hypoxia-inducible factor 1α expression in epithelial ovarian cancer: a meta-analysis. Tumor Biology, 35 (8), 8149-8159. doi: 10.1007/s13277-014-2059-x

Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma

Wang, Hui, Wang, Haolu, Chen, Tao, Liang, Xiaowen, Song, Yanyan and Wang, Jian (2014). Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma. World Journal of Surgical Oncology, 12 (1) 191. doi: 10.1186/1477-7819-12-191

Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair

Yang, L., Wang, H., Liang, X., Chen, T., Chen, W., Song, Y. and Wang, J. (2014). Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair. Hernia, 19 (2), 279-283. doi: 10.1007/s10029-014-1275-z

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058

In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe

Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978

Non-invasive assessment of the liver using imaging

Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883

Quantitative optical imaging of paracetamol-induced metabolism changes in the liver

Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962

Real-time optical imaging of the liver: diagnosis and prediction of treatment response

Wang, Haolu (2017). Real-time optical imaging of the liver: diagnosis and prediction of treatment response. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2017.646