The University of Queensland

Revealing interaction of dyes and nanomaterials by multiphoton imaging

Holmes, Amy, Thorling, Camilla, Liu, Xin, Liang, Xiaowen, Wang, Haolu, Breunig, Hans G., König, Karsten, Studier, Hauke and Roberts, Michael S. (2018). Revealing interaction of dyes and nanomaterials by multiphoton imaging. Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine. (pp. 345-368) edited by Karsten König. Berlin, Germany: Walter de Gruyter. doi: 10.1515/9783110429985-020

Hepatic metabolism in liver health and disease

Liu, X., Wang, H., Liang, X. and Roberts, M. S. (2017). Hepatic metabolism in liver health and disease. Liver Pathophysiology: Therapies and Antioxidants. (pp. 391-400) edited by Pablo Muriel. Cambridge, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-804274-8.00030-8

Related topic: Safety evaluation of nanomaterials

Liang, Xiaowen, Wang, Haolu, Liu, Xin, Grice, Jeffrey, Xu, Zhi Ping and Roberts, Michael S. (2017). Related topic: Safety evaluation of nanomaterials. Skin permeation and disposition of therapeutic and cosmeceutical compounds. (pp. 313-322) edited by Kenji Sugibayashi. Tokyo, Japan: Springer Japan. doi: 10.1007/978-4-431-56526-0_28

Optimizing drug dosing in the ICU

Kruger, P., Liu, X. and Roberts, M. S. (2009). Optimizing drug dosing in the ICU. Optimizing Drug Dosing in the ICU. (pp. 859-869) edited by Vincent, JL. Berlin, Germany: Springer. doi: 10.1007/978-3-540-92276-6

Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study

Novy, Emmanuel, Liu, Xin, Hernandez-Mitre, Maria Patricia, Belveyre, Thibaut, Scala-Bertola, Julien, Roberts, Jason A. and Parker, Suzanne L. (2024). Population pharmacokinetics of prophylactic cefoxitin in elective bariatric surgery patients: a prospective monocentric study. Anaesthesia Critical Care and Pain Medicine, 43 (3) 101376, 1-8. doi: 10.1016/j.accpm.2024.101376

Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis

Ngougni Pokem, Perrin, Liu, Xin, Parker, Suzanne L., Verroken, Alexia, Collienne, Christine, Finet, Patrice, Wijnant, Gert-Jan, Laterre, Pierre-François, Roberts, Jason A., Van Bambeke, Françoise and Wittebole, Xavier (2024). Population pharmacokinetics and dosing simulations of total and unbound temocillin in the plasma and CSF of neurocritically ill patients with external ventricular drain-related cerebral ventriculitis. Journal of Antimicrobial Chemotherapy, 79 (2), 429-442. doi: 10.1093/jac/dkad398

Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions

Zou, Da, Wu, Zeming, Yi, Xin, Hui, Yue, Yang, Guangze, Liu, Yun, Tengjisi,, Wang, Haofei, Brooks, Anastasia, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S., Gao, Huajian and Zhao, Chun-Xia (2022). Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions. Proceedings of the National Academy of Sciences, 120 (1) e2214757120, e2214757120. doi: 10.1073/pnas.2214757120

Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing

Liu, Xin, Cheruvu, Hanumanth S., Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Ghosh, Priyanka, Grice, Jeffrey E. and Roberts, Michael S. (2022). Percutaneous absorption of steroids from finite doses: predicting urinary excretion from in vitro skin permeation testing. International Journal of Pharmaceutics, 625 122095, 1-16. doi: 10.1016/j.ijpharm.2022.122095

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis

Liu, Xin, Wang, Haolu, Liu, Xinyao, Bridle, Kim, Crawford, Darrell and Liang, Xiaowen (2022). Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: a systematic review and meta-analysis. Pharmacology and Therapeutics, 237 108163, 1-13. doi: 10.1016/j.pharmthera.2022.108163

An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E and Roberts, Michael S. (2022). An updated database of human maximum skin fluxes and epidermal permeability coefficients for drugs, xenobiotics, and other solutes applied as aqueous solutions. Data in Brief, 42 108242, 1-9. doi: 10.1016/j.dib.2022.108242

Artificial cells for the treatment of liver diseases

Zou, Da, Wang, Haolu, Liu, Xin, Xu, Zhi Ping, Roberts, Michael S. and Zhao, Chun-Xia (2021). Artificial cells for the treatment of liver diseases. Acta Biomaterialia, 130, 98-114. doi: 10.1016/j.actbio.2021.06.012

Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models

Liu, Xin, Anissimov, Yuri G., Grice, Jeffrey E., Cheruvu, Hanumanth Srikanth, Ghosh, Priyanka, Raney, Sam G., Maibach, Howard and Roberts, Michael S. (2021). Relating transdermal delivery plasma pharmacokinetics with in vitro permeation test (IVPT) findings using diffusion and compartment-in-series models. Journal of Controlled Release, 334, 37-51. doi: 10.1016/j.jconrel.2021.04.010

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

Liu, Xin, Yousef, Shereen, Anissimov, Yuri G., van der Hoek, John, Tsakalozou, Eleftheria, Ni, Zhanglin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose. European Journal of Pharmaceutics and Biopharmaceutics, 149, 30-44. doi: 10.1016/j.ejpb.2020.01.018

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

Wang, Haolu, Burke, Leslie J., Patel, Jatin, Tse, Brian W.C., Bridle, Kim R., Cogger, Victoria C., Li, Xinxing, Liu, Xin, Yang, Haotian, Crawford, Darrell H. G., Roberts, Michael S., Gao, Wenchao and Liang, Xiaowen (2020). Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics, 10 (15), 6715-6727. doi: 10.7150/thno.44900

Modeling percutaneous absorption for successful drug discovery and development

Cheruvu, Hanumanth Srikanth, Liu, Xin, Grice, Jeffrey E. and Roberts, Michael S. (2020). Modeling percutaneous absorption for successful drug discovery and development. Expert Opinion on Drug Discovery, 15 (10), 1-18. doi: 10.1080/17460441.2020.1781085

Anionic long-circulating quantum dots for long-term intravital vascular imaging

Wang, Haolu, Yang, Haotian, Xu, Zhi Ping, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Anionic long-circulating quantum dots for long-term intravital vascular imaging. Pharmaceutics, 10 (4) 244, 244. doi: 10.3390/pharmaceutics10040244

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8

Wu, Chao, Kan, Hongwei, Hu, Min, Liu, Xin, Boye, Alex, Jiang, Yufeng, Wu, Jiajun, Wang, Jiyu, Yang, Xiaochuan and Yang, Yan (2018). Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocarcinogenesis via modulating TGF-β/tβr and imp7/8. Experimental and Therapeutic Medicine, 16 (2), 1052-1060. doi: 10.3892/etm.2018.6292

Indocyanine green-incorporating nanoparticles for cancer theranostics

Wang, Haolu, Li, Xinxing, Tse, Brian Wan-Chi, Yang, Haotian, Thorling, Camilla A., Liu, Yuxin, Touraud, Margaux, Chouane, Jean Batiste, Liu, Xin, Roberts, Michael S. and Liang, Xiaowen (2018). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics, 8 (5), 1227-1242. doi: 10.7150/thno.22872

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Jin, Wang, Liang, Xiaowen, Brooks, Anastasia, Futrega, Kathryn, Liu, Xin, Doran, Michael R., Simpson, Matthew J., Roberts, Michael S. and Wang, Haolu (2018). Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice. PeerJ, 2018 (12) e6072, e6072. doi: 10.7717/peerj.6072

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells

Brooks, Anastasia, Futrega, Kathryn, Liang, Xiaowen, Hu, Xiaoling, Liu, Xin, Crawford, Darrell H. G., Doran, Michael R., Roberts, Michael S. and Wang, Haolu (2017). Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells. Stem Cells Translational Medicine, 7 (1), 78-86. doi: 10.1002/sctm.17-0209

Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells

Wang, Haolu, Thorling, Camilla A., Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells. Current Protocols in Stem Cell Biology, 43 (1), 1-17. doi: 10.1002/cpsc.39

Multiphoton imaging for assessing renal disposition in acute kidney injury

Liu, Xin, Liang, Xiaowen, Wang, Haolu, Roberts, Darren M. and Roberts, Michael S. (2017). Multiphoton imaging for assessing renal disposition in acute kidney injury. SPIE Biophotonics Australasia, 10013. doi: 10.1117/12.2242964

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Wang, Haolu, Zhang, Run, Bridle, Kim R., Jayachandran, Aparna, Thomas, James A., Zhang, Wenzhu, Yuan, Jingli, Xu, Zhi Ping, Crawford, Darrell H. G., Liang, Xiaowen, Liu, Xin and Roberts, Michael S. (2017). Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Scientific Reports, 7 (1) 45374. doi: 10.1038/srep45374

Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions

Yousef, Shereen, Liu, Xin, Mostafa, Ahmed, Mohammed, Yousuf, Grice, Jeffrey E., Anissimov, Yuri G., Sakran, Wedad and Roberts, Michael S. (2016). Estimating maximal in vitro skin permeation flux from studies using non-sink receptor phase conditions. Pharmaceutical Research, 33 (9), 2180-2194. doi: 10.1007/s11095-016-1955-8

Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy

Wang, Haolu, Liang, Xiaowen, Gravot, Germain, Thorling, Camilla A., Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2016). Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy. Journal of Biophotonics, 10 (1), 46-60. doi: 10.1002/jbio.201600083

A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells

Wang, Haolu, Liang, Xiaowen, Xu, Zhi Ping, Crawford, Darrell H. G, Liu, Xin and Roberts, Michael S. (2016). A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports, 6 (1) 22293, e22293.1-e22293.12. doi: 10.1038/srep22293

Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles

Liang, Xiaowen, Wang, Haolu, Grice, Jeffrey E., Li, Li, Liu, Xin, Xu, Zhi Ping and Roberts, Michael S. (2016). Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles. Nano Letters, 16 (2), 939-945. doi: 10.1021/acs.nanolett.5b03854

Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney

Liang, Xiaowen, Wang, Haolu, Zhu, Yian, Zhang, Run, Cogger, Victoria C., Liu, Xin, Xu, Zhi Ping, Grice, Jeffrey E. and Roberts, Michael S. (2016). Short- and long-term tracking of anionic ultrasmall nanoparticles in kidney. Acs Nano, 10 (1), 387-395. doi: 10.1021/acsnano.5b05066

Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects

Jin, Yue, Wang, Haolu, Ma, Xiaowei, Liang, Xiaowen, Liu, Xin and Wang, Yu (2015). Clinicopathological characteristics of gynecological cancer associated with hypoxia-inducible factor 1α expression: a meta-analysis including 6,612 subjects. PLoS ONE, 10 (5) e0127229, e0127229. doi: 10.1371/journal.pone.0127229

Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection

Mahmood, Adnan H., Liu, Xin, Grice, Jeffrey E., Medley, Gregory A. and Roberts, Michael S. (2015). Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection. International Journal of Pharmaceutics, 481 (1-2), 71-78. doi: 10.1016/j.ijpharm.2015.01.046

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

Roberts, Darren M, Liu, Xin, Roberts, Jason A, Nair, Priya, Cole, Louise, Roberts, Michael S, Lipman, Jeffrey, Bellomo, Rinaldo and RENAL Replacement Therapy Study Investigators (2015). A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics. Critical Care, 19 (84) 84, 84. doi: 10.1186/s13054-015-0818-8

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging

Wang, Haolu, Liang, Xiaowen, Mohammed, Yousuf H., Thomas, James A., Bridle, Kim R., Thorling, Camilla A., Grice, Jeffrey E., Xu, Zhi Ping, Liu, Xin, Crawford, Darrell H. G. and Roberts, Michael S. (2015). Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express, 6 (3), 780-792. doi: 10.1364/BOE.6.000780

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

Wang, Haolu, Thorling, Camilla A., Liang, Xiaowen, Bridle, Kim R., Grice, Jeffrey E., Zhu, Yian, Crawford, Darrell H. G., Xu, Zhi Ping, Liu, Xin and Roberts, Michael S. (2015). Diagnostic imaging and therapeutic application of nanoparticles targeting the liver. Journal of Materials Chemistry B, 3 (6), 939-958. doi: 10.1039/C4TB01611D

Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition

Thorling C.A., Jin L., Weiss M., Crawford D., Liu X., Burczynski F.J., Liu D., Wang H. and Roberts M.S. (2015). Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. Drug Metabolism and Disposition, 43 (1), 154-162. doi: 10.1124/dmd.114.060848

Using skin for drug delivery and diagnosis in the critically ill

Liu, Xin, Kruger, Peter, Maibach, Howard, Colditz, Paul B. and Roberts, Michael S. (2014). Using skin for drug delivery and diagnosis in the critically ill. Advanced Drug Delivery Reviews, 77, 40-49. doi: 10.1016/j.addr.2014.10.004

Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach

Wunnapuk, Klintean, Mohammed, Fahim, Gawarammana, Indika, Liu, Xin, Verbeeck, Roger K., Buckley, Nicholas A., Roberts, Michael S. and Musuamba, Flora T. (2014). Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach. British Journal of Clinical Pharmacology, 78 (4), 855-866. doi: 10.1111/bcp.12389

Multiphoton microscopy in defining liver function

Thorling, Camilla A., Crawford, Darrell, Burczynski, Frank J., Liu, Xin, Liau, Ian and Roberts, Michael S. (2014). Multiphoton microscopy in defining liver function. Journal of Biomedical Optics, 19 (9) 090901, 90901-090901. doi: 10.1117/1.JBO.19.9.090901

Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats

Thorling, Camilla A., Roberts, Michael S., Liu, Xin, Fletcher, Linda M., Crawford, Darrell and Burczynski, Frank J. (2014). Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats. Journal of Pharmacy and Pharmaceutical Sciences, 17 (1), 121-135. doi: 10.18433/J33C7B

Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance

Wunnapuk, Klintean, Liu, Xin, Gobe, Glenda C., Endre, Zoltan H., Peake, Philip W., Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2014). Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance. Toxicology Letters, 225 (3), 467-478. doi: 10.1016/j.toxlet.2014.01.018

Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers

Wunnapuk, Klintean, Gobe, Glenda, Endre, Zoltan, Peake, Philip, Grice, Jeffrey E., Roberts, Michael S., Buckley, Nicholas A. and Liu, Xin (2014). Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225 (1), 192-200. doi: 10.1016/j.toxlet.2013.12.009

Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription

Rui, Wenjuan, Xie, Lei, Liu, Xin, He, Shufang, Wu, Chao, Zhang, Xiaoxiang, Zhang, Linjie and Yang, Yan (2014). Compound Astragalus and Salvia miltiorrhiza extract suppresses hepatocellular carcinoma progression by inhibiting fibrosis and PAI-1 mRNA transcription. Journal of Ethnopharmacology, 151 (1), 198-209. doi: 10.1016/j.jep.2013.10.022

Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells

Liang X., Grice J.E., Zhu Y., Liu D., Sanchez W.Y., Li Z., Crawford D.H.G., Le Couteur D.G., Cogger V.C., Liu X., Xu Z.P. and Roberts M.S. (2014). Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 11 (14), 1711-1720. doi: 10.1002/smll.201402698

Penetration of Nanoparticles into Human Skin

Liang, Xiao Wen, Xu, Zhi Ping, Grice, Jeffrey, Zvyagin, Andrei V., Roberts, Michael S. and Liu, Xin (2013). Penetration of Nanoparticles into Human Skin. Current Pharmaceutical Design, 19 (35), 6353-6366. doi: 10.2174/1381612811319350011

Renal biomarkers predict nephrotoxicity after paraquat

Wunnapuk, Klintean, Liu, Xin, Peake, Philip, Gobe, Glenda, Endre, Zoltan, Grice, Jeffrey E., Roberts, Michael S. and Buckley, Nicholas A. (2013). Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222 (3), 280-288. doi: 10.1016/j.toxlet.2013.08.003

Functional characterization of hepatic transporters using intravital microscopy

Weiss, Michael, Liu, Xin, Thorling, Camilla A. and Roberts, Michael S. (2013). Functional characterization of hepatic transporters using intravital microscopy. European Journal of Pharmaceutical Sciences, 49 (5), 845-849. doi: 10.1016/j.ejps.2013.06.006

Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study

Shao, Feng, Zhu, Tian, Tang, Feng and Liu, Xin (2013). Simultaneous quantification of tafetinib (SIM010603), a novel potent inhibitor of receptor tyrosine kinase, and its major metabolite in dog plasma by HPLC-ESI/MS/MS and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis, 81-82, 50-55. doi: 10.1016/j.jpba.2013.02.041

The development of models for the evaluation of pulmonary drug disposition

Liu, Xin, Jin, Lu, Upham, John W. and Roberts, Michael S. (2013). The development of models for the evaluation of pulmonary drug disposition. Expert Opinion On Drug Metabolism & Toxicology, 9 (4), 487-505. doi: 10.1517/17425255.2013.754009

Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury

Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M., Roberts, Michael S. and Sanchez, Washington Y. (2013). Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury. Journal of Biomedical Optics, 18 (10) 101306, 1-12. doi: 10.1117/1.JBO.18.10.101306

The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis

Liu, Xin, Kruger, Peter S., Weiss, Michael and Roberts, Michael S. (2012). The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. British Journal of Clinical Pharmacology, 73 (5), 741-749. doi: 10.1111/j.1365-2125.2011.04149.x

Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study

Roberts, Darren M., Roberts, Jason A., Roberts, Michael S., Liu, Xin, Nair, Priya, Cole, Louise, Lipman, Jeffrey, Bellomo, Rinaldo and on behalf of the RENAL Replacement Therapy Study Investigators (2012). Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study. Critical Care Medicine, 40 (5), 1523-1528. doi: 10.1097/CCM.0b013e318241e553

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway

He, S., Yang, Y., Liu, X., Huang, W., Zhang, X., Yang, S. and Zhang, X. (2012). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor-beta/Smad pathway. British Journal of Dermatology, 166 (3), 564-574. doi: 10.1111/j.1365-2133.2011.10674.x

Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection

Mahmood, Adnan H., Medley, Gregory A., Grice, Jeffrey E., Liu, Xin and Roberts, Michael S. (2012). Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection. Journal of Pharmaceutical and Biomedical Analysis, 62, 220-223. doi: 10.1016/j.jpba.2012.01.007

Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics

Jayaraman, Ramesh, Reddy, Venkatesh P., Pasha, Mohammed Khalid, Wang, Haishan, Sangthongpitag, Kanda, Yeo, Pauline, Hu, Chang Yong, Wu, Xiaofeng, Xin, Liu, Goh, Evelyn, New, Lee Sun and Ethirajulu, Kantharaj (2011). Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metabolism and Disposition, 39 (12), 2219-2232. doi: 10.1124/dmd.111.041558

Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man

Liu, Xin, Grice, Jeff E., Lademann, Juergen, Otberg, Nina, Trauer, Sindy, Patzelt, Alexa and Roberts, Michael S. (2011). Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man. British Journal of Clinical Pharmacology, 72 (5), 768-774. doi: 10.1111/j.1365-2125.2011.04022.x

Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats

Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M., Gobe, Glenda C. and Roberts, Michael S. (2011). Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats. Journal of Biomedical Optics, 16 (11) 116011, 116011-1160118. doi: 10.1117/1.3647597

Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

Wunnapuk, Klintean, Medley, Gregory A., Liu, Xin, Grice, Jeffrey E., Jayasinghe, Sudheera, Gawarammana, Indika, Buckley, Nicholas A. and Roberts, Michael S. (2011). Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 879 (28), 3047-3052. doi: 10.1016/j.jchromb.2011.09.008

Multiphoton microscopy and fluorescence lifetime imaging provide a novel method in studying drug distribution and metabolism in the rat liver in vivo

Thorling, Camilla A., Dancik, Yuri, Hupple, Clinton W., Medley, Gregory, Liu, Xin, Zvyagin, Andrei V., Robertson, Tom A., Burczynski, Frank J. and Roberts, Michael S. (2011). Multiphoton microscopy and fluorescence lifetime imaging provide a novel method in studying drug distribution and metabolism in the rat liver in vivo. Journal of Biomedical Optics, 16 (8) 086013, 086013-1-086013-7. doi: 10.1117/1.3614473

Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry

Mostafa, Ahmed, Medley, Gregory, Roberts, Darren M., Mohamed, Mosaad Sayed, Elshanawani, Abdalla A., Roberts, Michael S. and Liu, Xin (2011). Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 879 (23), 2234-2238. doi: 10.1016/j.jchromb.2011.06.006

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile

Wang, Haishan, Yu, Niefang, Chen, Dizhong, Lee, Ken Chi Lik, Lye, Pek Ling, Chang, Joyce Wei Wei, Deng, Weiping, Ng, Melvin Chi Yeh, Lu, Ting, Khoo, Mui Ling, Poulsen, Anders, Sangthongpitag, Kanda, Wu, Xiaofeng, Hu, Changyong, Goh, Kee Chuan, Wang, Xukun, Fang, Lijuan, Goh, Kay Lin, Khng, Hwee Hoon, Goh, Siok Kun, Yeo, Pauline, Liu, Xin, Bonday, Zahid, Wood, Jeanette M., Dymock, Brian W., Kantharaj, Kanthara and Sun, Eric T. (2011). Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. Journal of Medicinal Chemistry, 54 (13), 4694-4720. doi: 10.1021/jm2003552

How to measure pharmacokinetics in critically ill patients?

Liu, Xin, Kruger, Peter S. and Roberts, Michael S. (2011). How to measure pharmacokinetics in critically ill patients?. Current Pharmaceutical Biotechnology, 12 (12), 2037-2043. doi: 10.2174/138920111798808239

Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate

Roberts, Michael S., Liu, Xin, Zou, Yuhong, Siebert, Gerhard A., Chang, Ping, Whitehouse, Michael W., Fletcher, Linda and Crawford, Darrell H. G. (2011). Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate. American Journal of Physiology-gastrointestinal And Liver Physiology, 300 (1), G130-G136. doi: 10.1152/ajpgi.00162.2010

Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing

Liu, Xin, Zou, Yuhong, Khlentzos, Alexander M., Yang, Yan, Nikolovski, Julijana, Weiss, Michael and Roberts, Michael S. (2010). Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing. Clinical and Experimental Pharmacology and Physiology, 37 (10), 1028-1033. doi: 10.1111/j.1440-1681.2010.05434.x

Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts

He, S., Liu, X., Yang, Y., Huang, W., Xu, S., Yang, S., Zhang, X. and Roberts, M. S. (2010). Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. British Journal of Dermatology, 162 (3), 538-546. doi: 10.1111/j.1365-2133.2009.09511.x

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2

Liu, Xin, Yang, Yan, Zhang, Xiaoxiang, Xu, Shengxin, He, Shufang, Huang, Weijuan and Roberts, Michael S. (2010). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2. Journal of Gastroenterology and Hepatology, 25 (2), 420-426. doi: 10.1111/j.1440-1746.2009.05981.x

Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model

Zou, Yu-Hong, Liu, Xin, Khlentzos, Alexander M., Asadian, Peyman, Li, Peng, Thorling, Camilla A., Robertson, Thomas A., Fletcher, Linda M., Crawford, Darrell H. G. and Roberts, Michael S. (2010). Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model. Drug Metabolism and Pharmacokinetics, 25 (5), 442-449. doi: 10.2133/dmpk.DMPK-10-RG-031

Influence of perfusate composition on drug disposition in the in-situ perfused rat lung

Liu, X., Wang, J. Y., Khlentzos, A. M., Fontaine, F., Nikolovski, J., Goh, L.- A. and Roberts, M. S. (2009). Influence of perfusate composition on drug disposition in the in-situ perfused rat lung. International Journal of Pharmaceutics, 382 (1-2), 192-197. doi: 10.1016/j.ijpharm.2009.08.028

Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.

Liu, Xin, Chan, S. Y. and Ho, P. C. (2008). Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.. Cancer Chemotherapy and Pharmacology, 63 (1), 167-174. doi: 10.1007/s00280-008-0763-1

The prediction of the hepatic clearance of Tanshinone IIA in a rat liver subcellular fractions: accuracy improvement

Li, P., Wang, G-J., Li, J., Liu, X., Khlentzos, A. and Roberts, M. S. (2008). The prediction of the hepatic clearance of Tanshinone IIA in a rat liver subcellular fractions: accuracy improvement. Current Drug Metabolism, 9 (1), 39-45. doi: 10.2174/138920008783331103

In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species

Venkadesh, Pilla Reddy, Goh, Evelyn, Zeng, Peizi, New, Lee Sun, Liu, Xin, Pasha, Mohammed Khalid, Sangthongpitag, Kanda, Yeo, Pauline and Kantharaj, Ethirajulu (2007). In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species. Biological and Pharmaceutical Bulletin, 30 (5), 1021-1024. doi: 10.1248/bpb.30.1021

Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies

Yeo, Pauline, Xin, Liu, Goh, Evelyn, New, Lee Sun, Zeng, Peizi, Wu, Xiaofeng, Venkatesh, P. and Kantharaj, Ethirajulu (2007). Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies. Biomedical Chromatography, 21 (2), 184-189. doi: 10.1002/bmc.734

Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis

Yap, K. L., Liu, X., Thenmozhiyal, J. C. and Ho, P. C. (2005). Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. European Journal of Pharmaceutical Sciences, 25 (1), 49-56. doi: 10.1016/j.ejps.2005.01.021

Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats

Liu, X., Lin, H. S., Chan, S. Y. and Ho, P. C. (2004). Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats. Journal of Pharmaceutical Sciences, 93 (4), 805-815. doi: 10.1002/jps.10578

Inclusion of acitretin into cyclodextrins: Phase solubility, photostability, and physicochemical characterization

Liu, X., Lin, H. S., Thenmozhiyal, J. C., Chan, S. Y. and Ho, P. C. (2003). Inclusion of acitretin into cyclodextrins: Phase solubility, photostability, and physicochemical characterization. Journal of Pharmaceutical Sciences, 92 (12), 2449-2457. doi: 10.1002/jps.10495

Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes

Roberts, Michael S., Barkauskas, Deborah, Wang, Haolu, Liu, Xin, Studier, Hauke, Pastore, Michael, Zhang, Run, Holmes, Amy, Grice, Jeffrey E., Xu, Zhiping, Mohammed, Yousuf S. and Liang, Xiaowen (2020). Multiphoton and FLIM imaging in quantifying ex vivo and in vivo body organ kinetics of solutes. Multiphoton Microscopy in the Biomedical Sciences, San Francisco, CA United States, 2-4 February 2020. Bellingham, WA United States: SPIE. doi: 10.1117/12.2546058

Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis

Wang, H., Liang, X., Weijs, L., Brooks, A., Liu, X., Roberts, M. S. and Crawford, D. H. G. (2017). Characterizing and predicting the in vivo kinetics of mesenchymal stem cells and their secretome for the treatment of liver cirrhosis. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, Queensland, 20–22 Aug 2017. Hoboken, NJ United States: Wiley.

In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe

Wang, Haolu, Jayachandran, Aparna, Gravot, Germain, Liang, Xiaowen, Thorling, Camilla A., Zhang, Run, Liu, Xin and Roberts, Michael S. (2017). In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe. SPIE BioPhotonics Australasia Conference, Adelaide,SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.2242978

Non-invasive assessment of the liver using imaging

Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242883

Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity

Liang, X., Wang, H., Liu, X., Touraud, M., Chouane, J. B., Tse, B. and Roberts, M. S. (2017). Novel mechanistic imaging biomarkers for early prediction of acetaminophen-induced hepatotoxicity. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, , Gold Coast, Queensland, Australia, 20–22 Aug 2017. Richmond, VIC Australia: Wiley.

Quantitative optical imaging of paracetamol-induced metabolism changes in the liver

Liang, Xiaowen, Wang, Haolu, Liu, Xin and Roberts, Michael (2017). Quantitative optical imaging of paracetamol-induced metabolism changes in the liver. SPIE BioPhotonics Australasia, Adelaide, SA, Australia, 17 - 19 October 2016. Bellingham, WA, United States: International Society for Optical Engineering. doi: 10.1117/12.2242962

A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo

Wang, H., Liang, X., Endo-Munoz, L., Weijs, L., Liu, X., Crawford, D. and Roberts, M. (2015). A blood-flow limited physiologically based kinetic model to characterize and predict the biological fate of mesenchymal stem cells in vivo. Gastro 2015 GESA‐AGW And WGO International Congress, Gastroenterological Society Of Australia Australian Gastroenterology Week 2015 - World Congress Of Gastroenterology, , Brisbane, Queensland, Australia, 28 September‐2 October 2015. Richmond, VIC Australia: Wiley.

A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo

Wang, H., Liang, X., Thorling, C., Xu, Z. P., Crawford, D., Liu, X. and Roberts, M. (2015). A physiologically based kinetic model to characterize and predict the biological fate of circulating tumor cells in vivo. European Cancer Congress, Vienna, Austria, 2015. Hoboken, NJ United States: Wiley. doi: 10.1016/S0959-8049(15)30013-7

Early diagnosis of hepatocellular carcinoma by in vivo imaging

Liang, X., Wang, H., Zhu, Y., Grice, J., Liu, X., Xu, Z. and Roberts, M. (2015). Early diagnosis of hepatocellular carcinoma by in vivo imaging. European Cancer Congress, Vienna, Austria, 2015. Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(16)30378-1

Effect of hepatic ischemia reperfusion injury on the function of P-Glycoprotein in transporting Rhodamine 123

Thorling, Camilla A., Liu, Xin, Burczynski, Frank J., Fletcher, Linda M. and Roberts, Michael S. (2011). Effect of hepatic ischemia reperfusion injury on the function of P-Glycoprotein in transporting Rhodamine 123. 62nd Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, United States, 04-08 November 2011.

Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients

Roberts, D., Roberts, M., Liu, X., Roberts, J., Lipman, J. and Bellomo, R. (2010). Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients. ANZSN 2010: 46th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, WA, Australia, 12-15 September 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2010.01377_1.x

Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients

Roberts, D. M., Roberts, M. S., Liu, X., Roberts, J. A., Lipman, J. and Bellomo, R. (2010). Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients. ESICM 2010: 23rd Annual Meeting of the European Society of Intensive Care Medicine, Barcelona, Spain, 9-13 October, 2010. Heidelberg, Germany: Springer. doi: 10.1007/s00134-010-1999-x

ADME and PK/PD attributes of SB939, a potent orally active HDAC inhibitor

Sangthongpitag, K., Wang, H., Yeo, P., Liu, X., Goh, E., New, L., Zeng, P., Wu, X., Hu, C. and Ethirajulu, K. (2006). ADME and PK/PD attributes of SB939, a potent orally active HDAC inhibitor. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/S1359-6349(06)70172-0