The University of Queensland

Journal Article

• Alleviation of Diabetic Retinopathy by Glucose-Triggered Delivery of Vitamin D via Dextran-Gated Functionalized Mesoporous Silica Nanoparticles

  Sarkar, Sanjib, Osman, Narin, Thrimawithana, Thilini, Wann, Sawlang Borsingh, Kalita, Jatin and Manna, Prasenjit (2024). Alleviation of Diabetic Retinopathy by Glucose-Triggered Delivery of Vitamin D via Dextran-Gated Functionalized Mesoporous Silica Nanoparticles. ACS Applied Bio Materials, 7 (2), 1260-1270. doi: 10.1021/acsabm.3c01200

• Gαq is the specific mediator of PAR-1 transactivation of kinase receptors in vascular smooth muscle cells

  Kamato, Danielle, Gabr, Mai, Kumarapperuma, Hirushi, Chia, Zheng J., Zheng, Wenhua, Xu, Suowen, Osman, Narin and Little, Peter J. (2022). Gαq is the specific mediator of PAR-1 transactivation of kinase receptors in vascular smooth muscle cells. International Journal of Molecular Sciences, 23 (22) 14425, 14425. doi: 10.3390/ijms232214425

• Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling

  Kamato, Danielle, Do, Bich Hang, Osman, Narin, Ross, Benjamin P., Mohamed, Raafat, Xu, Suowen and Little, Peter J. (2019). Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling. Cellular and Molecular Life Sciences, 77 (2), 243-251. doi: 10.1007/s00018-019-03266-3

• Recent advances in the management of diabetic retinopathy

  Dulull, Nabeela, Kwa, Faith, Osman, Narin, Rai, Uma, Shaikh, Bilal and Thrimawithana, Thilini R. (2019). Recent advances in the management of diabetic retinopathy. Drug Discovery Today, 24 (8), 1499-1509. doi: 10.1016/j.drudis.2019.03.028

• Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation

  Kamato, Danielle, Ta, Hang, Afroz, Rizwana, Xu, Suowen, Osman, Narin and Little, Peter J. (2019). Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation. Journal of Cell Communication and Signaling, 13 (4), 539-548. doi: 10.1007/s12079-019-00527-5

• Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes

  Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53, 365-373. doi: 10.1016/j.cellsig.2018.11.005

• Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2

  Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483

• Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation

  Talati, Nirali, Kamato, Danielle, Piva, Terrence J, Little, Peter and Osman, Narin (2018). Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. Cellular Signalling, 47, 37-43. doi: 10.1016/j.cellsig.2018.03.009

• Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis

  Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187, 88-97. doi: 10.1016/j.pharmthera.2018.02.005

• RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

  Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 (7) e0180842, e0180842. doi: 10.1371/journal.pone.0180842

• Role played by signalling pathways in overcoming BRAF inhibitor resistance in melanoma

  Chan, Xian Yang, Singh, Alamdeep, Osman, Narin and Piva, Terrence J. (2017). Role played by signalling pathways in overcoming BRAF inhibitor resistance in melanoma. International Journal of Molecular Sciences, 18 (7) 1527, 1527.1-1527.13. doi: 10.3390/ijms18071527

• Gaq proteins: molecular pharmacology and therapeutic potential

  Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9

• The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle

  Rostam, Muhamad A., Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cellular Signalling, 28 (8), 956-966. doi: 10.1016/j.cellsig.2016.05.002

• Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells

  Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 (9), 1041-1051. doi: 10.7150/ijbs.16134

• Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response

  Bernard, Rebekah, Getachew R., Kamato, D., Thach L., Osman N., Chan V., Zheng W. and Little P. J. (2016). Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. Journal of Pharmacy and Pharmacology, 68 (3), 368-378. doi: 10.1111/jphp.12530

• Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling

  Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398

• Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans

  Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016). Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612, 2913612-7. doi: 10.1155/2016/2913612

• Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes

  Kamato, Danielle, Thach, Lyna, Getachew, Robel, Burch, Micah, Hollenberg, Morley D., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling, 28 (1), 110-119. doi: 10.1016/j.cellsig.2015.11.003

• Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools

  Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014). Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools. Clinical & Experimental Pharmacology, 04 (05). doi: 10.4172/2161-1459.1000164

• Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation

  Kamato, Danielle, Burch, Micah L., Piva, Terrence J., Rezaei, Hossein Babaahmadi, Rostam, Muhamad Ashraf, Xu, Suowen, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2013). Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cellular Signalling, 25 (10), 2017-2024. doi: 10.1016/j.cellsig.2013.06.001

• (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells

  Kamato, Danielle, Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Guidone, Daniel, Osman, Narin, Roufogalis, Basil, Duke, Colin C., Van Hoan Tran, Zheng, Wenhua and Little, Peter J. (2013). (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1026-1036. doi: 10.1111/jphp.12060

• Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells

  Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua and Osman, Narin (2013). Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1055-1063. doi: 10.1111/jphp.12064

• Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

  Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua and Little, Peter J. (2013). Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. Journal of Pharmacy and Pharmacology, 65 (4), 465-473. doi: 10.1111/j.2042-7158.2012.01577.x

• Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans

  Osman, Narin, Grande-Allen, K. Jane, Ballinger, Mandy L., Getachew, Robel, Marasco, Silvana, O'Brien, Kevin D. and Little, Peter J. (2013). Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovascular Pathology, 22 (2), 146-155. doi: 10.1016/j.carpath.2012.07.002

• Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation

  Little, Peter J., Getachew, Robel, Rezaei, Hossein Babaahmadi, Sanchez-Guerrero, Estella, Khachigian, Levon M., Wang, Haitao, Liao, Sufen, Zheng, Wenhua, Ballinger, Mandy L. and Osman, Narin (2012). Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation. Archives of Biochemistry and Biophysics, 525 (1), 25-31. doi: 10.1016/j.abb.2012.05.025

• G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors

  Burch, Micah L., Osman, Narin, Getachew, Robel, Al-aryahi, Sefaa, Poronnik, Philip, Zheng, Wenhua, Hill, Michael A. and Little, Peter J. (2012). G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors. International Journal of Biochemistry and Cell Biology, 44 (5), 722-727. doi: 10.1016/j.biocel.2012.01.018

• TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle

  Osman, Narin, Getachew, Robel, Burch, Micah, Lancaster, Graeme, Wang, Rikang, Wang, Haitau, Zheng, Wenhua and Little, Peter J. (2011). TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. Growth Factors, 29 (5), 203-210. doi: 10.3109/08977194.2011.615747

• Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor

  Little, Peter J., Burch, Micah L., Getachew, Robel, Al-aryahi, Sefaa and Osman, Narin (2010). Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor. Journal of Cardiovascular Pharmacology, 56 (4), 360-368. doi: 10.1097/FJC.0b013e3181ee6811

• Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor

  Burch, Micah L., Ballinger, Mandy L., Yang, Sundy N. Y., Getachew, Robel, Itman, Catherine, Loveland, Kate, Osman, Narin and Little, Peter J. (2010). Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor. Journal of Biological Chemistry, 285 (35), 26798-26805. doi: 10.1074/jbc.M109.092767

• Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells

  Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Little, Peter J. and Osman, Narin (2010). Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells. European Journal of Pharmacology, 626 (2-3), 186-192. doi: 10.1016/j.ejphar.2009.09.066

• TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2

  Burch, Micah L., Yang, Sundy N. Y., Ballinger, Mandy L., Getachew, Robel, Osman, Narin and Little, Peter J. (2010). TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. Cellular and Molecular Life Sciences, 67 (12), 2077-2090. doi: 10.1007/s00018-010-0315-9

• Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL

  Ballinger, M. L., Ivey, M. E., Osman, N., Thomas, W. G. and Little, P. J. (2009). Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. Atherosclerosis, 205 (2), 451-457. doi: 10.1016/j.atherosclerosis.2009.01.024

• Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding

  Ballinger, Mandy L., Osman, Narin, Wilks, Andrew F., Su, Stephen, Phd, Christopher J. Burns, Bu, Xianyong and Little, Peter J. (2008). Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding. Journal of Cardiovascular Pharmacology, 52 (5), 403-412. doi: 10.1097/FJC.0b013e31818a8907

• Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis

  Ivey, Melanie E., Osman, Narin and Little, Peter J. (2008). Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis. Atherosclerosis, 199 (2), 237-247. doi: 10.1016/j.atherosclerosis.2008.03.006

• Calcific aortic valve disease and hypertension

  Dadlani, Harsha, Osman, Narin, Ballinger, Mandy L., Marasco, Silvana and Little, Peter J. (2008). Calcific aortic valve disease and hypertension. Current Hypertension Reviews, 4 (2), 107-113. doi: 10.2174/157340208784245884

• Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis

  Sudhir, Krishnankutty, Nigro, Julie, Osman, Narin and Little, Peter J. (2005). Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis. Thescientificworldjournal, 5, 521-526. doi: 10.1100/tsw.2005.75

• New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix

  Nigro, Julie, Ballinger, Mandy L., Survase, Soniya, Osman, Narin and Little, Peter J. (2005). New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix. Thescientificworldjournal, 5 (2), 515-520. doi: 10.1100/tsw.2005.69