Journal Article: Endocytosis in cancer and cancer therapy
Banushi, Blerida, Joseph, Shannon R., Lum, Benedict, Lee, Jason J. and Simpson, Fiona (2023). Endocytosis in cancer and cancer therapy. Nature Reviews Cancer, 23 (7), 1-24. doi: 10.1038/s41568-023-00574-6
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Journal Article: Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis
McInerney-Leo, Aideen M., Chew, Hui Yi, Inglis, Po-Ling, Leo, Paul J., Joseph, Shannon R., Cooper, Caroline L., Okano, Satomi, Hassall, Tim, Anderson, Lisa, Bowman, Rayleen V., Gattas, Michael, Harris, Jessica E., Marshall, Mhairi S., Shaw, Janet G., Wheeler, Lawrie, Yang, Ian A., Brown, Matthew A., Fong, Kwun M., Simpson, Fiona and Duncan, Emma L. (2021). Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis. Human Molecular Genetics, 30 (24), 2393-2401. doi: 10.1093/hmg/ddab172
Clinical utility of [68Ga] FAPI PET/CT in patients with potentially resectable pancreatic cancer
(2023–2024) TRI Leading Innovations through New Collaborations Scheme
(2020) PA Research Foundation
(2018–2020) PA Research Foundation
Regulating immune system activity in oncology and auto-immune diseases.
Doctor Philosophy
Novel Biomarkers and Therapy Approaches in Breast Cancer
Doctor Philosophy
Drug target stability and drug metabolism by tumour cells in vivo
Doctor Philosophy
Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma
Joseph, Shannon R., Endo-Munoz, Liliana, Gaffney, Daniel C., Saunders, Nicholas A. and Simpson, Fiona (2015). Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma. Actinic keratosis. (pp. 20-27) edited by H. Peter Soyer, Tarl W. Prow and Gregor B.E. Jemec. Basel, Switzerland: S Karger AG. doi: 10.1159/000367959
Endocytosis in cancer and cancer therapy
Banushi, Blerida, Joseph, Shannon R., Lum, Benedict, Lee, Jason J. and Simpson, Fiona (2023). Endocytosis in cancer and cancer therapy. Nature Reviews Cancer, 23 (7), 1-24. doi: 10.1038/s41568-023-00574-6
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
McInerney-Leo, Aideen M., Chew, Hui Yi, Inglis, Po-Ling, Leo, Paul J., Joseph, Shannon R., Cooper, Caroline L., Okano, Satomi, Hassall, Tim, Anderson, Lisa, Bowman, Rayleen V., Gattas, Michael, Harris, Jessica E., Marshall, Mhairi S., Shaw, Janet G., Wheeler, Lawrie, Yang, Ian A., Brown, Matthew A., Fong, Kwun M., Simpson, Fiona and Duncan, Emma L. (2021). Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis. Human Molecular Genetics, 30 (24), 2393-2401. doi: 10.1093/hmg/ddab172
Karlsen, Emma-Anne, Kahler, Sam, Tefay, Joan, Joseph, Shannon R. and Simpson, Fiona (2021). Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: a review. Cells, 10 (5) 1206, 1206. doi: 10.3390/cells10051206
Joseph, Shannon R., Lum, Benedict, Banushi, Blerida, Barry, Rachael, Panizza, Benedict, Walpole, Euan and Simpson, Fiona (2020). Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples. STAR Protocols, 1 (2) 100087, 100087. doi: 10.1016/j.xpro.2020.100087
Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019
de Lima, Priscila Oliveira, Joseph, Shannon, Panizza, Benedict and Simpson, Fiona (2020). Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies. Current Treatment Options in Oncology, 21 (1) 9, 9. doi: 10.1007/s11864-019-0697-3
Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190
He, Xuzhi, Cruz, Jazmina L., Joseph, Shannon, Pett, Nicola, Chew, Hui Yi, Tuong, Zewen K., Okano, Satomi, Kelly, Gabrielle, Veitch, Margaret, Simpson, Fiona and Wells, James W. (2018). Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Oncotarget, 9 (15), 12250-12260. doi: 10.18632/oncotarget.24242
Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis
Daniel, James A., Chau, Ngoc, Abdel-Hamid, Mohammed K., Hu, Lingbo, von Kleist, Lisa, Whiting, Ainslie, Krishnan, Sai, Maamary, Peter, Joseph, Shannon R., Simpson, Fiona, Haucke, Volker, McCluskey, Adam and Robinson, Philip J. (2015). Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis. Traffic, 16 (6), 635-654. doi: 10.1111/tra.12272
Joseph, Shannon, Hu, Lingbo and Simpson, Fiona (2011). KIAA0101 (KIAA0101). Atlas of Genetics and Cytogenetics in Oncology and Haematology
Desclozeaux, Marion, Venturato, Juliana, Wylie, Fiona G., Kay, Jason G., Joseph, Shannon R., Le, Huong T. and Stow, Jennifer L. (2008). Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Americal Journal of Physiology: Cell Physiology, 295 (2), C545-C556. doi: 10.1152/ajpcell.00097.2008
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin
Bryant, D. M., Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120 (10), 1818-1828. doi: 10.1242/jcs.000653
Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X
Miranda, K. C., Joseph, S. R., Yap, A. S., Teasdale, R. D. and Stow, J. L. (2003). Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia. Journal of Biological Chemistry, 278 (44), 43480-43488. doi: 10.1074/jbc.M305525200
Protein kinase C regulates endocytosis and recycling of E-cadherin
Le, T. L., Joseph, S. R., Yap, A. S. and Stow, J. L. (2002). Protein kinase C regulates endocytosis and recycling of E-cadherin. American Journal of Physiology-cell Physiology, 283 (2), C489-C499. doi: 10.1152/ajpcell.00566.2001
Stow, J, Bryant, D and Joseph, S (2004). Endocytosis of E-cadherin in polarized epithelia - Joint regulation of growth factor receptor internalisation and signaling. Experimental Biology 2004 Meeting, Washington Dc, Apr 17-21, 2004. BETHESDA: FEDERATION AMER SOC EXP BIOL.
Joseph, SR, Miranda, KC and Stow, JL (2002). p120ctn binds to the cadherin/catenin complex only after delivery to the basolateral plasma membrane in MDCK cells. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, Dec 14-18, 2002. BETHESDA: AMER SOC CELL BIOLOGY.
The exocytic and endocytic trafficking of E-cadherin in epithelial cells
Joseph, Shannon Rose (2007). The exocytic and endocytic trafficking of E-cadherin in epithelial cells. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/158535
Clinical utility of [68Ga] FAPI PET/CT in patients with potentially resectable pancreatic cancer
(2023–2024) TRI Leading Innovations through New Collaborations Scheme
(2020) PA Research Foundation
(2018–2020) PA Research Foundation
(2017–2022) Princess Alexandra Hospital R&D Foundation
Cell biological mechanism of reversing resistance to cancer therapeutic antibodies
(2016–2017) Research Donation Generic
Regulating immune system activity in oncology and auto-immune diseases.
Doctor Philosophy — Associate Advisor
Other advisors:
Novel Biomarkers and Therapy Approaches in Breast Cancer
Doctor Philosophy — Associate Advisor
Other advisors:
Drug target stability and drug metabolism by tumour cells in vivo
Doctor Philosophy — Associate Advisor
Other advisors:
The Ins and Outs of Endocytosis inhibition: Providing diverse opportunities for treatment of incurable cancers
Doctor Philosophy — Associate Advisor
Other advisors:
EGFR and Treg targeted therapies for cutaneous squamous cell carcinoma
(2019) Doctor Philosophy — Associate Advisor