The University of Queensland

IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation

Zhang, Ping, Fleming, Peter, Andoniou, Christopher E., Waltner, Olivia G., Bhise, Shruti S., Martins, Jose Paulo, McEnroe, Benjamin A., Voigt, Valentina, Daly, Sheridan, Kuns, Rachel D., Ekwe, Adaeze P., Henden, Andrea S., Saldan, Alda, Olver, Stuart, Varelias, Antiopi, Smith, Corey, Schmidt, Christine R., Ensbey, Kathleen S., Legg, Samuel R.W., Sekiguchi, Tomoko, Minnie, Simone A., Gradwell, Mark, Wagenaar, Irma, Clouston, Andrew D., Koyama, Motoko, Furlan, Scott N., Kennedy, Glen A., Ward, E Sally, Degli-Esposti, Mariapia A. ... Tey, Siok-Keen (2024). IL-6–mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation. Journal of Clinical Investigation, 134 (7) e174184. doi: 10.1172/jci174184

Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells

Ekwe, Adaeze Precious, Au, Raymond, Zhang, Ping, McEnroe, Benjamin, Tan, Mei Ling, Saldan, Alda, Henden, Andrea S., Hutchins, Cheryl, Henderson, Ashleigh, Mudie, Kari, Kerr, Keri, Fuery, Madonna, Kennedy, Glen A., Hill, Geoffrey R. and Tey, Siok-Keen (2024). Clinical grade multiparametric cell sorting and gene-marking of regulatory T cells. Cytotherapy. doi: 10.1016/j.jcyt.2024.02.023

Feasibility of prebiotic enteral nutrition provision during allogeneic stem cell transplantation

Andersen, S., Kennedy, G., Banks, M. and Henden, A. (2023). Feasibility of prebiotic enteral nutrition provision during allogeneic stem cell transplantation. Clinical Nutrition ESPEN, 58, 426. doi: 10.1016/j.clnesp.2023.09.012

ANZTCT consensus position statement on ruxolitinib in steroid‐refractory acute and chronic graft‐versus‐host disease

Hamad, Nada, Bilmon, Ian, Chee, Lynette, Henden, Andrea, Johnston, Anna, Purtill, Duncan, Bajel, Ashish, Tey, Siok‐Keen, Yeung, David, Cole, Theresa, Lewis, Clinton and Butler, Jason (2023). ANZTCT consensus position statement on ruxolitinib in steroid‐refractory acute and chronic graft‐versus‐host disease. Internal Medicine Journal, 53 (12), 2319-2329. doi: 10.1111/imj.16255

Quantifying skin cancer risk following allogeneic haematopoietic cell transplant in Queensland, Australia

Wong, Philip, Whiteman, David C., Olsen, Catherine M., Yuan, Yin, Butler, Jason, Curley, Cameron, Durrant, Simon, Henden, Andrea, Morton, James, Subramoniapillai, Elango, Stewart, Caroline, Tey, Siok-Keen, Kennedy, Glen A. and Scott, Ashleigh P. (2023). Quantifying skin cancer risk following allogeneic haematopoietic cell transplant in Queensland, Australia. Bone Marrow Transplantation, 59 (1) ARTN s41409-023-02138-6, 144-146. doi: 10.1038/s41409-023-02138-6

PET assessment of acute gastrointestinal graft versus host disease

Scott, Ashleigh P., Henden, Andrea, Kennedy, Glen A. and Tey, Siok-Keen (2023). PET assessment of acute gastrointestinal graft versus host disease. Bone Marrow Transplantation, 58 (9), 973-979. doi: 10.1038/s41409-023-02038-9

Immunotherapy: PHASE 1 CLINICAL TRIAL OF CD19 CAR-T CELLS MANUFACTURED AT THE POINT-OF-CARE

Hutchins, C.J., Henderson, A., Lynam, E.C., Abaca-Cleopas, M., Harvey, K.J., Acworth, M.C., Leung, C., Barnes, E., Robb, R.J., Mudie, K., O’Donnell, M., Perera, N., Pillai, E. Subramonia, Curley, C., Henden, A., Kennedy, G. and Tey, S. (2023). Immunotherapy: PHASE 1 CLINICAL TRIAL OF CD19 CAR-T CELLS MANUFACTURED AT THE POINT-OF-CARE. Cytotherapy, 25 (6), S229. doi: 10.1016/s1465-3249(23)00579-0

High incidence of resistant breakthrough invasive fungal infections (IFD) in patients treated for acute gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic haematopoietic cell transplantation

Yuan, Yin, Wong, Philip, Butler, Jason P., Henden, Andrea, Curley, Cameron, Durrant, Simon, Mediwake, Heshani, Morton, A. James, Stewart, Caroline, Subramoniapillai, Elango, Weber, Nicholas, Tey, Siok-Keen, Kennedy, Glen A. and Scott, Ashleigh P. (2022). High incidence of resistant breakthrough invasive fungal infections (IFD) in patients treated for acute gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic haematopoietic cell transplantation. Bone Marrow Transplantation, 57 (11), 1-4. doi: 10.1038/s41409-022-01773-9

CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant

Yeh, Albert C., Varelias, Antiopi, Reddy, Anupama, Barone, Sierra M., Olver, Stuart D., Chilson, Kate, Onstad, Lynn E., Ensbey, Kathleen S., Henden, Andrea S, Samson, Luke, Jaeger, Carla A, Bi, Timothy, Dahlman, Kimberly B., Kim, Tae Kon, Zhang, Ping, Degli-Esposti, Mariapia A., Newell, Evan W., Jagasia, Madan H., Irish, Jonathan M., Lee, Stephanie J. and Hill, Geoffrey R. (2021). CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant. Blood, 138 (26), 2874-2885. doi: 10.1182/blood.2020009492

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis

Kennedy, Glen, Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart, Chang, Karshing, Butler, Jason, Misra, Ashish, Subramoniapillai, Elango, Morton, Anthony, Durrant, Simon, Henden, Andrea S, Moore, John, Ritchie, David S, Gottlieb, David, Cooney, Julian P, Paul, Sanjoy K and Hill, Geoffrey R. (2021). A phase 3 double-blind study of the addition of tocilizumab versus placebo to cyclosporin/methotrexate GvHD prophylaxis. Blood, 137 (14), 1970-1979. doi: 10.1182/blood.2020009050

Infectious complications of CAR T-cell therapy: a clinical update

Stewart, Adam G. and Henden, Andrea S. (2021). Infectious complications of CAR T-cell therapy: a clinical update. Therapeutic Advances in Infectious Disease, 8 204993612110367, 1-11. doi: 10.1177/20499361211036773

Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation

Gartlan, Kate H, Wilkinson, Andrew, Chang, Karshing, Kuns, Rachel D, Henden, Andrea, Minnie, Simone A, Ensbey, Kathleen S, Clouston, Andrew, Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica and Hill, Geoffrey R (2020). Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation. The Journal of Immunology, 204 (1_Supplement), 87.33-87.33. doi: 10.4049/jimmunol.204.supp.87.33

Mapping functional susceptibilities in AML

Lane, Steven and Henden, Andrea (2020). Mapping functional susceptibilities in AML. The Hematologist, 17 (1). doi: 10.1182/hem.v17.1.10162

MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 (5), 885-898. doi: 10.1016/j.immuni.2019.08.011

Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation

Henden, Andrea S., Varelias, Antiopi, Leach, Justine, Sturgeon, Elise, Avery, Judy, Kelly, Jessica, Olver, Stuart, Samson, Luke, Hartel, Gunter, Durrant, Simon, Butler, Jason, Morton, Anthony J., Misra, Ashish, Tey, Siok-Keen, Subramoniapillai, Elango, Curley, Cameron, Kennedy, Glen and Hill, Geoffrey R. (2019). Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation. Blood Advances, 3 (20), 3013-3019. doi: 10.1182/bloodadvances.2019000453

Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract

Gartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood Advances, 3 (19), 2859-2865. doi: 10.1182/bloodadvances.2019000053

Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology

Koyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S, Henden, Andrea S, Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D, Robb, Renee J, Zhang, Ping, Blazar, Bruce R., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D, Degli-Esposti, Mariapia A and Hill, Geoffrey R. (2019). Immune responses to the microbiome tune MHC class II antigen presentation by the intestinal epithelium to control gut pathology. The Journal of Immunology, 202 (1_Supplement), 69.38-69.38. doi: 10.4049/jimmunol.202.supp.69.38

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. The Journal of Immunology, 200 (1_Supplement), 55.15-55.15. doi: 10.4049/jimmunol.200.supp.55.15

Recipient mucosal-associated invariant T cells control GVHD within the colon

Varelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Mathew, Nimitha R., Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A., Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L., Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael ... Zeiser, Robert (2018). Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine, 24 (3), 282-291. doi: 10.1038/nm.4484

Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD

Markey, Kate A., Kuns, Rachel D., Browne, Daniel J., Gartlan, Kate H., Robb, Renee J., Martins, J. Paulo, Henden, Andrea S., Minnie, Simone A., Cheong, Melody, Koyama, Motoko, Smyth, Mark J., Steptoe, Raymond J., Belz, Gabrielle, Brocker, Thomas, Degli-Esposti, Mariapia A., Lane, Steven W. and Hill, Geoffrey R. (2018). Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD. Clinical Cancer Research, 24 (7), 1604-1616. doi: 10.1158/1078-0432.CCR-17-2148

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L, Bunting, Mark D, Koyama, Motoko, Gartlan, Kate H, Kuns, Rachel D, Lachner, Nancy, Locke, Kelly R, Lim, Chun Y, Henden, Andrea S, Zhang, Ping, Clouston, Andrew D, Hasnain, Sumaira Z, McGuckin, Michael A, Blazar, Bruce R, MacDonald, Kelli PA, Hugenholtz, Philip and Hill, Geoff R (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. The Journal of Immunology, 198 (1_Supplement), 82.8-82.8. doi: 10.4049/jimmunol.198.supp.82.8

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A ., Hugenholtz, Philip and Hill, Geoffrey R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Blood, 129 (15), 2172-2185. doi: 10.1182/blood-2016-08-732628

Cytokines in graft-versus-host disease

Henden, Andrea S. and Hill, Geoffrey R. (2015). Cytokines in graft-versus-host disease. Journal of Immunology, 194 (10), 4604-4612. doi: 10.4049/jimmunol.1500117

Incidence and outcomes of invasive fungal disease in adult patients with acute lymphoblastic leukemia treated with hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone: implications for prophylaxis

Henden, Andrea, Morris, Kirk, Truloff, Natasha, Nakagaki, Midori and Kennedy, Glen A. (2013). Incidence and outcomes of invasive fungal disease in adult patients with acute lymphoblastic leukemia treated with hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone: implications for prophylaxis. Leukemia and Lymphoma, 54 (6), 1329-1331. doi: 10.3109/10428194.2012.740561

Myeloid and lymphoid neoplasm with FGFR1 abnormality

Keane, Colm, Henden, Andrea, Mills, Tony and Wood, Peter (2009). Myeloid and lymphoid neoplasm with FGFR1 abnormality. British Journal of Haematology, 145 (4), 440-440. doi: 10.1111/j.1365-2141.2008.07480.x

Catastrophic tumour lysis syndrome following single dose of imatinib

Keane, Colm, Henden, Andrea and Bird, Robert (2009). Catastrophic tumour lysis syndrome following single dose of imatinib. European Journal of Haematology, 82 (3), 244-245. doi: 10.1111/j.1600-0609.2008.01186.x

Real-world outcomes with CD19 CAR T-cell therapy for B-cell malignancies in regional/rural Australia: results from the Queensland CAR T-Cell Program

Perera, Nilu, Scott, Ashleigh P., Hunt, Stewart, Curley, Cameron, Tey, Siok-Keen, Butler, Jason, Henden, Andrea S, Pillai, Elango S., Hutchins, Cheryl, Mudie, Kari Louise and Kennedy, Glen A. (2022). Real-world outcomes with CD19 CAR T-cell therapy for B-cell malignancies in regional/rural Australia: results from the Queensland CAR T-Cell Program. Unknown, Unknown, Unknown. Washington, DC USA: American Society of Hematology. doi: 10.1182/blood-2022-168399

Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd

Henden, Andrea S., Robb, Renee, Forero, Adriana, Kuns, Rachel D., Ensbey, Kathleen S., Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nic, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey (2021). Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd. 2021 TCT Meetings of ASTCT and CIBMTR, Online, 8-12 February 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2666-6367(21)00107-x

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. Immunology Meeting, Austin Tx, 4-8 May 2018. Bethesda, MD United States: American Association of Immunologists.

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, Antiopi, Ormerod, Kate L., Bunting, Mark D., Koyama, Motoko, Gartlan, Kate H., Kuns, Rachel D., Lachner, Nancy, Locke, Kelly R., Lim, Chun Y., Henden, Andrea S., Zhang, Ping, Clouston, Andrew D., Hasnain, Sumaira Z., McGuckin, Michael A., Blazar, Bruce R., MacDonald, Kelli P. A., Hugenholtz, Philip and Hill, Geoff R. (2017). Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome. Immunology Meeting, Washington DC, 12-16 May 2017. Bethesda, MD United States: American Association of Immunologists.

IL-28 Is a critical cytoprotectant in transplantation

Henden, A., Robb, R., Clouston, A., Kuns, R., Lane, S., Gartlan, K. and Hill, G. (2016). IL-28 Is a critical cytoprotectant in transplantation. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley-VCH.