David graduated from the University of London with a BSc (Hons) in biochemistry (King’s College) and PhD which investigated the role of epidermal growth factor receptors in liver regeneration (Imperial College). Since then he has worked on a variety of projects including; immunoassay development (Ortho Clinical Diagnostics); artificial liver machine development (Imperial College); and p53 mutations in liver cancer (QIMR). He joined the Department of Nephrology at the Princess Alexandra Hospital in Brisbane in 1999. He is a senior lecturer in The University of Queensland Faculty of Medicine, a senior member of the UQ Kidney Disease Research Laboratory and manages the Princess Alexandra Hospital Endotoxin Testing Service.
His main research interests are in the area of renal tubulointerstitial fibrosis, inflammation and also the mechanisms of renal cancer development – particularly the role that cytokines and growth factors play in these processes. Current projects include the role of protease activated receptor-2 in renal scarring, inflammation and cancer, the mechanism of heavy metal toxicity in the kidney and the renoprotective properties of erythropoietin. The Princess Alexandra Hospital Endotoxin Testing Service routinely tests samples from dialysis units throughout Queensland.
Journal Article: Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria
Satarug, Soisungwan, Vesey, David A., Khamphaya, Tanaporn, Pouyfung, Phisit, Gobe, Glenda C. and Yimthiang, Supabhorn (2023). Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria. Toxics, 11 (9) 755, 755. doi: 10.3390/toxics11090755
Conference Publication: Evaluating kidney fibrosis using in vivo 1h magnetic resonance spectroscopy in patients with chronic kidney disease and live donors
Humphries, Tyrone, Dong, Xin, Watson, Julia, Mountford, Carolyn, Ellis, Robert, Vesey, David, Galloway, Graham, Gobe, Glenda and Francis, Ross (2023). Evaluating kidney fibrosis using in vivo 1h magnetic resonance spectroscopy in patients with chronic kidney disease and live donors. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4–6 September 2023. Richmond, VIC Australia: John Wiley & Sons.
Journal Article: Gender Differences in the Severity of Cadmium Nephropathy
Yimthiang, Supabhorn, Vesey, David A., Gobe, Glenda C., Pouyfung, Phisit, Khamphaya, Tanaporn and Satarug, Soisungwan (2023). Gender Differences in the Severity of Cadmium Nephropathy. Toxics, 11 (7) 616, 616. doi: 10.3390/toxics11070616
(2013–2015) UQ Academic Title Holder Research Fund
Enhancing erythropoietin therapy in ischaemia-reperfusion injury of heart and kidney
(2010–2013) NHMRC Project Grant
Protease activated receptor 2 antagonist in inflammatory disease
(2010–2012) NHMRC Development Grant
Exploring magnetic resonance for differentiating between progressive and non-progressive chronic kidney disease
Doctor Philosophy
Clinical Biobanking and the Distinguishing Risk of Progressive Chronic Kidney Disease Study
(2021) Doctor Philosophy
Exploring Resistance of Renal Cell Carcinoma to Sunitinib Therapy
(2020) Doctor Philosophy
Isolation and primary culture of human proximal tubule cells
Vesey, David A., Qi, Weier, Chen, Xingming, Pollock, Carol A. and Johnson, David W. (2009). Isolation and primary culture of human proximal tubule cells. Kidney Research: Experimental Protocols. (pp. 19-24) edited by John M. Walker, T. D. Hewitson and G. J. Becker. Clifton, NJ, U.S.A.: Humana Press. doi: 10.1007/978-1-59745-352-3_2
Satarug, Soisungwan, Vesey, David A., Khamphaya, Tanaporn, Pouyfung, Phisit, Gobe, Glenda C. and Yimthiang, Supabhorn (2023). Estimation of the Cadmium Nephrotoxicity Threshold from Loss of Glomerular Filtration Rate and Albuminuria. Toxics, 11 (9) 755, 755. doi: 10.3390/toxics11090755
Gender Differences in the Severity of Cadmium Nephropathy
Yimthiang, Supabhorn, Vesey, David A., Gobe, Glenda C., Pouyfung, Phisit, Khamphaya, Tanaporn and Satarug, Soisungwan (2023). Gender Differences in the Severity of Cadmium Nephropathy. Toxics, 11 (7) 616, 616. doi: 10.3390/toxics11070616
Yimthiang, Supabhorn, Pouyfung, Phisit, Khamphaya, Tanaporn, Vesey, David A., Gobe, Glenda C. and Satarug, Soisungwan (2023). Evidence Linking Cadmium Exposure and β2-Microglobulin to Increased Risk of Hypertension in Diabetes Type 2. Toxics, 11 (6) 516, 516. doi: 10.3390/toxics11060516
Chronic kidney disease induced by cadmium and diabetes: a quantitative case-control study
Yimthiang, Supabhorn, Vesey, David A., Pouyfung, Phisit, Khamphaya, Tanaporn, Gobe, Glenda C. and Satarug, Soisungwan (2023). Chronic kidney disease induced by cadmium and diabetes: a quantitative case-control study. International Journal of Molecular Sciences, 24 (10) 9050, 1-15. doi: 10.3390/ijms24109050
Cadmium-induced tubular dysfunction in type 2 diabetes: a population-based cross-sectional study
Satarug, Soisungwan, Yimthiang, Supabhorn, Pouyfung, Phisit, Khamphaya, Tanaporn and Vesey, David A. (2023). Cadmium-induced tubular dysfunction in type 2 diabetes: a population-based cross-sectional study. Toxics, 11 (4) 390, 1-14. doi: 10.3390/toxics11040390
Humphries, Tyrone L.R., Vesey, David A., Galloway, Graham J., Gobe, Glenda C. and Francis, Ross S. (2023). Identifying disease progression in chronic kidney disease using proton magnetic resonance spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy, 134-135, 52-64. doi: 10.1016/j.pnmrs.2023.04.001
Cadmium-induced proteinuria: mechanistic insights from dose–effect analyses
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2023). Cadmium-induced proteinuria: mechanistic insights from dose–effect analyses. International Journal of Molecular Sciences, 24 (3) 1893, 1-14. doi: 10.3390/ijms24031893
Satarug, Soisungwan, Vesey, David A., Gobe, Glenda C., Yimthiang, Supabhorn and Buha Đorđević, Aleksandra (2023). Health risk in a geographic area of Thailand with endemic cadmium contamination: focus on albuminuria. Toxics, 11 (1) 68. doi: 10.3390/toxics11010068
Estimation of health risks associated with dietary cadmium exposure
Satarug, Soisungwan, Vesey, David A., Gobe, Glenda C. and Phelps, Kenneth R. (2023). Estimation of health risks associated with dietary cadmium exposure. Archives of Toxicology, 97 (2), 329-358. doi: 10.1007/s00204-022-03432-w
The validity of benchmark dose limit analysis for estimating permissible accumulation of cadmium
Satarug, Soisungwan, Vesey, David A., Gobe, Glenda C. and Đorđević, Aleksandra (2022). The validity of benchmark dose limit analysis for estimating permissible accumulation of cadmium. International Journal of Environmental Research and Public Health, 19 (23) 15697, 1-15. doi: 10.3390/ijerph192315697
Targeted biomarkers of progression in chronic kidney disease
Owens, Evan Paul, Healy, Helen Grania, Vesey, David Alan, Hoy, Wendy Elizabeth and Gobe, Glenda Carolyn (2022). Targeted biomarkers of progression in chronic kidney disease. Clinica Chimica Acta, 536, 18-28. doi: 10.1016/j.cca.2022.08.025
Satarug, Soisungwan, Đorđević, Aleksandra Buha, Yimthiang, Supabhorn, Vesey, David A. and Gobe, Glenda C. (2022). The NOAEL equivalent of environmental cadmium exposure associated with gfr reduction and chronic kidney disease. Toxics, 10 (10) 614, 1-16. doi: 10.3390/toxics10100614
Dheda, Shyam, Min, Hongjin, Vesey, David A., Hawley, Carmel, Johnson, David W., Dimeski, Goce, Healy, Helen and Fahim, Magid (2022). Pre-dialysis levels of inflammation and endotoxin in people receiving hemodialysis are not associated with blood pressure variability. Clinical Nephrology, 98 (4), 198-204. doi: 10.5414/CN110656
Mitigation of Cadmium Toxicity through Modulation of the Frontline Cellular Stress Response
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2022). Mitigation of Cadmium Toxicity through Modulation of the Frontline Cellular Stress Response. Stresses, 2 (3), 355-372. doi: 10.3390/stresses2030025
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2022). Dose–response analysis of the tubular and glomerular effects of chronic exposure to environmental cadmium. International Journal of Environmental Research and Public Health, 19 (17) 10572, 1-14. doi: 10.3390/ijerph191710572
Multiple targets of toxicity in environmental exposure to low-dose cadmium
Satarug, Soisungwan, Gobe, Glenda C. and Vesey, David A. (2022). Multiple targets of toxicity in environmental exposure to low-dose cadmium. Toxics, 10 (8) 472, 1-20. doi: 10.3390/toxics10080472
Effect of a hemodialysis session on markers of inflammation and endotoxin
Dheda, Shyam, Vesey, David A, Hawley, Carmel, Johnson, David W and Fahim, Magid (2022). Effect of a hemodialysis session on markers of inflammation and endotoxin. International Journal of Inflammation, 2022 8632245, 8632245-7. doi: 10.1155/2022/8632245
Yimthiang, Supabhorn, Pouyfung, Phisit, Khamphaya, Tanaporn, Kuraeiad, Saruda, Wongrith, Paleeratana, Vesey, David A., Gobe, Glenda C. and Satarug, Soisungwan (2022). Effects of environmental exposure to cadmium and lead on the risks of diabetes and kidney dysfunction. International Journal of Environmental Research and Public Health, 19 (4) 2259, 1-12. doi: 10.3390/ijerph19042259
Kamli, Hossam, Owens, Evan P., Vesey, David A., Prasanna, Rajagopalan, Li, Li, Gobe, Glenda C. and Morais, Christudas (2022). Overcoming sunitinib resistance with tocilizumab in renal cell carcinoma: discordance between in vitro and in vivo effects. Biochemical and Biophysical Research Communications, 586, 42-48. doi: 10.1016/j.bbrc.2021.11.069
Humphries, Tyrone L. R., Shen, Kunyu, Iyer, Abishek, Johnson, David W., Gobe, Glenda C., Nikolic-Paterson, David, Fairlie, David P. and Vesey, David A. (2021). PAR2-induced tissue factor synthesis by primary cultures of human kidney tubular epithelial cells is modified by glucose availability. International Journal of Molecular Sciences, 22 (14) 7532, 1-12. doi: 10.3390/ijms22147532
The evolving role for zinc and zinc transporters in cadmium tolerance and urothelial cancer
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2021). The evolving role for zinc and zinc transporters in cadmium tolerance and urothelial cancer. Stresses, 1 (2), 105-118. doi: 10.3390/stresses1020009
Morais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983
Iyer, Abishek, Humphries, Tyrone L. R., Owens, Evan P., Zhao, Kong-Nan, Masci, Paul P., Johnson, David W., Nikolic-Paterson, David, Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Frontiers in Physiology, 12 615428, 615428. doi: 10.3389/fphys.2021.615428
Satarug, Soisungwan, Vesey, David A., Nishijo, Muneko, Ruangyuttikarn, Werawan, Gobe, Glenda C. and Phelps, Kenneth R. (2021). The Effect of Cadmium on GFR Is Clarified by Normalization of Excretion Rates to Creatinine Clearance. International Journal of Molecular Sciences, 22 (4) 1762, 1-16. doi: 10.3390/ijms22041762
Humphries, Tyrone L.R., Johnson, Lambro A., Masci, Paul P., Gobe, Glenda C. and Vesey, David A. (2021). Progress curve analysis of microtitre plate plasma clotting assays. Assessment of tissue factor levels. Analytical Biochemistry, 614 114060, 114060. doi: 10.1016/j.ab.2020.114060
Satarug, Soisungwan, Gobe, Glenda C., Ujjin, Pailin and Vesey, David A. (2020). Gender differences in zinc and copper excretion in response to co-exposure to low environmental concentrations of cadmium and lead. Stresses, 1 (1), 3-15. doi: 10.3390/stresses1010002
Development of a biomarker panel to distinguish risk of progressive chronic kidney disease
Owens, Evan, Tan, Ken-Soon, Ellis, Robert, Del Vecchio, Sharon, Humphries, Tyrone, Lennan, Erica, Vesey, David, Healy, Helen, Hoy, Wendy and Gobe, Glenda (2020). Development of a biomarker panel to distinguish risk of progressive chronic kidney disease. Biomedicines, 8 (12) 606, 606-16. doi: 10.3390/biomedicines8120606
Cadmium and lead exposure, nephrotoxicity, and mortality
Satarug, Soisungwan, Gobe, Glenda C., Vesey, David A. and Phelps, Kenneth R. (2020). Cadmium and lead exposure, nephrotoxicity, and mortality. Toxics, 8 (4) 86, 86-42. doi: 10.3390/toxics8040086
A comparison of the nephrotoxicity of low doses of cadmium and lead
Satarug, Soisungwan, Gobe, Glenda C., Ujjin, Pailin and Vesey, David A. (2020). A comparison of the nephrotoxicity of low doses of cadmium and lead. Toxics, 8 (1) 18, 18. doi: 10.3390/toxics8010018
The source and pathophysiologic significance of excreted cadmium
Satarug, Soisungwan, Vesey, David A., Ruangyuttikarn, Werawan, Nishijo, Muneko, Gobe, Glenda C. and Phelps, Kenneth R. (2019). The source and pathophysiologic significance of excreted cadmium. Toxics, 7 (4) 55. doi: 10.3390/toxics7040055
Shen, Kunyu, Vesey, David A., Hasnain, Sumaira Z., Zhao, Kong-Nan, Wang, Haolu, Johnson, David W., Saunders, Nicholas, Burgess, Melinda and Gobe, Glenda C. (2019). A cost-effective three-dimensional culture platform functionally mimics the adipose tissue microenvironment surrounding the kidney. Biochemical and Biophysical Research Communications, 522 (3), 736-742. doi: 10.1016/j.bbrc.2019.11.119
Ma, Frank Y., Han, Yingjie, Ozols, Elyce, Chew, Phyllis, Vesey, David A., Gobe, Glenda C., Morais, Christudas, Lohman, Rink-Jan, Suen, Jacky Y., Johnson, David W., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. Nephrology, 24 (9) nep.13635, 983-991. doi: 10.1111/nep.13635
Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate
Satarug, Soisungwan, Boonprasert, Kanyarat, Gobe, Glenda C., Ruenweerayut, Ronnatrai, Johnson, David W., Na-Bangchang, Kesara and Vesey, David A. (2019). Chronic exposure to cadmium is associated with a marked reduction in glomerular filtration rate. Clinical Kidney Journal, 12 (4), 468-475. doi: 10.1093/ckj/sfy113
Raj, Ashok S., Shanahan, Erin R., Tran, Cuong D., Bhat, Purnima, Fletcher, Linda M., Vesey, David A., Morrison, Mark, Holtmann, Gerald and Macdonald, Graeme A. (2019). Dysbiosis of the Duodenal Mucosal Microbiota Is Associated With Increased Small Intestinal Permeability in Chronic Liver Disease. Clinical and Translational Gastroenterology, 10 (8) e00068, e00068. doi: 10.14309/ctg.0000000000000068
Satarug, Soisungwan, Vesey, David A., Nishijo, Muneko, Ruangyuttikarn, Werawan and Gobe, Glenda C. (2019). The inverse association of glomerular function and urinary β2-MG excretion and its implications for cadmium health risk assessment. Environmental Research, 173, 40-47. doi: 10.1016/j.envres.2019.03.026
Owens, Evan P., Vesey, David A., Kassianos, Andrew J., Healy, Helen, Hoy, Wendy E. and Gobe, Glenda C. (2019). Biomarkers and the role of mast cells as facilitators of inflammation and fibrosis in chronic kidney disease. Translational Andrology and Urology, 8 (S2), S175-S183. doi: 10.21037/tau.2018.11.03
Han, Yingjie, Tian, Lifang, Ma, Frank, Tesch, Greg, Vesey, David A., Gobe, Glenda C., Lohman, Rink-Jan, Morais, Christudas, Suen, Jacky Y., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clinical and Experimental Pharmacology and Physiology, 46 (5) 1440-1681.13077, 456-464. doi: 10.1111/1440-1681.13077
Shen, Kunyu, Vesey, David A., Ellis, Robert J., Del Vecchio, Sharon Juliet, Cho, Yeoungjee, Teixeira-Pinto, Armando, McGuckin, Michael A., Johnson, David W. and Gobe, Glenda C. (2019). GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma. PLoS One, 14 (1) e0210246, e0210246. doi: 10.1371/journal.pone.0210246
Song, Wenzhe, Thakor, Parth, Vesey, David A., Gobe, Glenda C. and Morais, Christudas (2018). Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells. Biomedicine and Pharmacotherapy, 106, 247-254. doi: 10.1016/j.biopha.2018.06.126
Ng, K. L., Del Vecchio, S. J., Samaratunga, H., Morais, C., Rajandram, R., Vesey, D. A., Wood, S. T. and Gobe, G. C. (2018). Leptin and its receptor: can they help to differentiate chromophobe renal cell carcinoma from renal oncocytoma?. Pathology, 50 (5), 504-510. doi: 10.1016/j.pathol.2018.01.007
Is renal tubular cadmium toxicity clinically relevant?
Boonprasert, Kanyarat, Vesey, David A., Gobe, Glenda C., Ruenweerayut, Ronnatrai, Johnson, David W., Na-Bangchang, Kesara and Satarug, Soisungwan (2018). Is renal tubular cadmium toxicity clinically relevant?. Clinical Kidney Journal, 11 (5), 681-687. doi: 10.1093/ckj/sfx153
Kamli, Hossam, Gobe, Glenda C., Li, Li, Vesey, David A. and Morais, Christudas (2018). Characterisation of the Morphological, Functional and Molecular Changes in Sunitinib-Resistant Renal Cell Carcinoma Cells. Journal of Kidney Cancer and VHL, 5 (3), 1-9. doi: 10.15586/jkcvhl.2018.106
Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells
Ellis, Robert J., Small, David M., Ng, Keng Lim, Vesey, David A., Vitetta, Luis, Francis, Ross S., Gobe, Glenda C. and Morais, Christudas (2018). Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells. Toxicologic Pathology, 46 (4), 192623318768171-459. doi: 10.1177/0192623318768171
Ellis, Robert J., Del Vecchio, Sharon J., Ng, Keng Lim, Dimeski, Goce, Pascoe, Elaine M., Hawley, Carmel M., Johnson, David W., Vesey, David A., Coombes, Jeff S., Morais, Christudas, Francis, Ross S., Wood, Simon T. and Gobe, Glenda C. (2017). Factors associated with acutely elevated serum creatinine following radical tumour nephrectomy: the Correlates of Kidney Dysfunction-Tumour Nephrectomy Database study. Translational Andrology and Urology, 6 (5), 899-909. doi: 10.21037/tau.2017.08.15
Shen, Kunyu, Johnson, David W., Vesey, David A., McGuckin, Michael A. and Gobe, Glenda C. (2017). Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies. Cell Stress and Chaperones, 23 (3), 317-334. doi: 10.1007/s12192-017-0844-3
Current health risk assessment practice for dietary cadmium: data from different countries
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2017). Current health risk assessment practice for dietary cadmium: data from different countries. Food and Chemical Toxicology, 106 (A), 430-445. doi: 10.1016/j.fct.2017.06.013
Thakor, Parth, Song, Wenzhe, Subramanian, Ramalingam B., Thakkar, Vasudev R., Vesey, David A. and Gobe, Glenda C. (2017). Maslinic Acid Inhibits Proliferation of Renal Cell Carcinoma Cell Lines and Suppresses Angiogenesis of Endothelial Cells. Journal of Kidney Cancer and Vhl, 4 (1), 16-24. doi: 10.15586/jkcvhl.2017.64
Health risk assessment of dietary cadmium intake: do current guidelines indicate how much is safe?
Satarug, Soisungwan, Vesey, David A. and Gobe, Glenda C. (2017). Health risk assessment of dietary cadmium intake: do current guidelines indicate how much is safe?. Environmental Health Perspectives, 125 (3), 284-288. doi: 10.1289/EHP108
Kidney cadmium toxicity, diabetes and high blood pressure: the perfect storm
Satarug, Soisungwan , Vesey, David A. and Gobe, Glenda C. (2017). Kidney cadmium toxicity, diabetes and high blood pressure: the perfect storm. The Tohoku Journal of Experimental Medicine, 241 (1), 65-87. doi: 10.1620/tjem.241.65
Boonprasert, Kanyarat, Satarug, Soisungwan, Morais, Christudas, Gobe, Glenda C., Johnson, David W., Na-Bangchang, Kesara and Vesey, David A. (2016). The stress response of human proximal tubule cells to cadmium involves up-regulation of haemoxygenase 1 and metallothionein but not cytochrome P450 enzymes. Toxicology Letters, 249, 5-14. doi: 10.1016/j.toxlet.2016.02.016
Gobe, Glenda C., Ng, Keng Lim, Small, David M., Vesey, David A., Johnson, David W., Samaratunga, Hemamali, Oliver, Kimberley, Wood, Simon, Barclay, Johanna L., Rajandram, Retnagowri, Li, Li and Morais, Christudas (2016). Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways. Biochemical and Biophysical Research Communications, 473 (1), 47-53. doi: 10.1016/j.bbrc.2016.03.048
Indoxyl sulphate and kidney disease: causes, consequences and interventions
Ellis, Robert J., Small, David M., Vesey, David A., Johnson, David W., Francis, Ross, Vitetta, Luis, Gobe, Glenda C. and Morais, Christudas (2016). Indoxyl sulphate and kidney disease: causes, consequences and interventions. Nephrology, 21 (3), 170-177. doi: 10.1111/nep.12580
Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity
Yau, Mei-Kwan, Liu, Ligong, Lim, Junxian, Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky Y., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26 (3), 986-991. doi: 10.1016/j.bmcl.2015.12.048
Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis
Lohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328
Cho, Yeoungjee, Johnson, David W., Vesey, David A., Hawley, Carmel M., Pascoe, Elaine M., Clarke, Margaret and Topley, Nicholas (2016). Higher dialysate matrix metalloproteinase-2 levels are associated with peritoneal membrane dysfunction. Peritoneal Dialysis International, 36 (1), 16-25. doi: 10.3747/pdi.2013.00274
PAR2 modulators derived from GB88
Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306
Utility of urinary biomarkers in predicting loss of residual renal function: the balANZ trial
Cho, Yeoungjee, Johnson, David W., Vesey, David A., Hawley, Carmel M., Clarke, Margaret and Topley, Nicholas (2015). Utility of urinary biomarkers in predicting loss of residual renal function: the balANZ trial. Peritoneal Dialysis International, 35 (2), 159-171. doi: 10.3747/pdi.2013.00170
Baseline Serum Interleukin-6 Predicts Cardiovascular Events in Incident Peritoneal Dialysis Patients
Cho, Yeoungjee, Johnson, David W., Vesey, David A., Hawley, Carmel M., Pascoe, Elaine M., Clarke, Margaret and Topley, Nicholas (2015). Baseline Serum Interleukin-6 Predicts Cardiovascular Events in Incident Peritoneal Dialysis Patients. Peritoneal Dialysis International, 35 (1), 35-42. doi: 10.3747/pdi.2013.00272
Pathway-selective antagonism of proteinase activated receptor 2
Suen, J. Y., Cotterell, A., Lohman, R. J., Lim, J., Han, A., Yau, M. K., Liu, L., Cooper, M. A., Vesey, D. A. and Fairlie, D. P. (2014). Pathway-selective antagonism of proteinase activated receptor 2. British Journal of Pharmacology, 171 (17), 4112-4124. doi: 10.1111/bph.12757
Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro
Hornos Carneiro, Maria Fernanda, Morais, Christudas, Small, David M., Vesey, David A., Barbosa Jr, Fernando and Gobe, Glenda C. (2014). Thimerosal induces apoptotic and fibrotic changes to kidney epithelial cells in vitro. Environmental Toxicology, 30 (12), 1423-1433. doi: 10.1002/tox.22012
Gobe, Glenda C., Bennett, Nigel C., West, Malcolm, Colditz, Paul, Brown, Lindsay, Vesey, David A. and Johnson, David W. (2014). Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury. American Journal of Physiology-Renal Physiology, 306 (6), F681-F692. doi: 10.1152/ajprenal.00241.2013
Morais, Christudas, Small, David M., Vesey, David A., Martin, Jennifer, Johnson, David W. and Gobe, Glenda C. (2014). Fibronectin and transforming growth factor beta contribute to erythropoietin resistance and maladaptive cardiac hypertrophy. Biochemical and Biophysical Research Communications, In Press, Corrected Proof (3), 1-6. doi: 10.1016/j.bbrc.2014.01.047
Cho, Yeoungjee, Johnson, David W., Vesey, David A., Hawley, Carmel M., Pascoe, Elaine M., Clarke, Margaret, Topley, Nicholas and on behalf of the balANZ Trial Investigators (2014). Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients. BMC Nephrology, 15 (1) 8. doi: 10.1186/1471-2369-15-8
Rossi, M., Campbell, K.L., Johnson, D.W., Stanton, T., Vesey, D.A., Coombes, J.S., Weston, K.S., Hawley, C.M., McWhinney, B.C., Ungerer, J.P.J. and Isbel, N. (2013). Protein-bound uremic toxins, inflammation and oxidative stress: A cross-sectional study in stage 3-4 chronic kidney disease. Archives of Medical Research, 45 (4), 309-317. doi: 10.1016/j.arcmed.2014.04.002
Gobe, Glenda C., Morais, Christudas, Vesey, David A. and Johnson, David W. (2013). Use of high-dose erythropoietin for repair after injury: A comparison of outcomes in heart and kidney. Journal of Nephropathology, 2 (3), 154-165. doi: 10.12860/JNP.2013.27
PAR2-induced inflammatory responses in human kidney tubular epithelial cells
Vesey, David A., Suen, Jacky Y., Seow, Vernon, Lohman, Rink-Jan, Liu, Ligong, Gobe, Glenda C., Johnson, David W. and Fairlie, David P. (2013). PAR2-induced inflammatory responses in human kidney tubular epithelial cells. American Journal of Physiology - Renal Physiology, 304 (6), F737-F750. doi: 10.1152/ajprenal.00540.2012
Functional significance of erythropoietin in renal cell carcinoma
Morais, Christudas, Johnson, David W., Vesey, David A. and Gobe, Glenda C. (2013). Functional significance of erythropoietin in renal cell carcinoma. BMC Cancer, 13 (1) 14, 14.1-14.7. doi: 10.1186/1471-2407-13-14
Evidence for steroidogenic potential in human prostate cell lines and tissues
Bennett, Nigel C., Hooper, John D., Lambie, Duncan, Lee, Cheok S., Yang, Tao, Vesey, David A., Samaratunga, Hemamali, Johnson, David W. and Gobe, Glenda C. (2012). Evidence for steroidogenic potential in human prostate cell lines and tissues. American Journal of Pathology, 181 (3), 1078-1087. doi: 10.1016/j.ajpath.2012.06.009
Rajandram, Retnagowri, Bennett, Nigel C., Wang, Zhiqiang, Perry-Keene, Joanna, Vesey, David A., Johnson, David W. and Gobe, Glenda C. (2012). Patient samples of renal cell carcinoma show reduced expression of TRAF1 compared with normal kidney and functional studies in vitro indicate TRAF1 promotes apoptosis: Potential for targeted therapy. Pathology, 44 (5), 453-459. doi: 10.1097/PAT.0b013e3283557748
Lohman, Rink-Jan, Cotterell, Adam J., Barry, Grant D., Liu, Ligong, Suen, Jacky Y., Vesey, David A. and Fairlie, David P. (2012). An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. The FASEB Journal, 26 (7), 2877-2887. doi: 10.1096/fj.11-201004
Antagonism of protease-activated receptor 2 protects against experimental colitis.
Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky, Liu, Ligong, Do, Anh T., Vesey, David A. and Fairlie, David P. (2012). Antagonism of protease-activated receptor 2 protects against experimental colitis.. Journal of Pharmacology and Experimental Therapeutics, 340 (2), 256-265. doi: 10.1124/jpet.111.187062
Vesey, David A. (2010). Transport pathways for cadmium in the intestine and kidney proximal tubule: Focus on the interaction with essential metals. Toxicology Letters, 198 (1), 13-19. doi: 10.1016/j.toxlet.2010.05.004
Erythropoietin protects against acute kidney injury and failure
Johnson, David W., Vesey, David A. and Gobe, Glenda C. (2010). Erythropoietin protects against acute kidney injury and failure. The Open Drug Discovery Journal, 2 (SPEC. ISS.1), 8-17. doi: 10.2174/1877381801002010008
Li, Jun, Vesey, David A., Johnson, David W. and Gobe, Glenda C. (2007). Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway. Cancer Biology Therapy, 6 (12), 1944-1950. doi: 10.4161/cbt.6.12.4975
Proinflammatory and proliferative responses of human proximal tubule cells to PAR-2 activation
Vesey, David A., Kruger, Wade A., Poronnik, Philip, Gobe, Glenda C. and Johnson, David W. (2007). Proinflammatory and proliferative responses of human proximal tubule cells to PAR-2 activation. American Journal of Physiology: Renal Physiology, 293 (5), F1441-F1449. doi: 10.1152/ajprenal.00088.2007
Cheung, Catherine W., Taylor, Paul J., Kirkpatrick, Carl M.J., Vesey, David A., Gobe, Glenda C., Winterford, Clay, Nicol, David L. and Johnson, David W. (2007). Therapeutic value of orally administered silibinin in renal cell carcinoma: Manipulation of insulin-like growth factor binding protein-3 levels. BJU International, 100 (2), 438-444. doi: 10.1111/j.1464-410X.2007.07012.x
Yang, Tao, Vesey, David A., Johnson, David W., Wei, Ming Q. and Gobe, Glenda C. (2007). Apoptosis of tubulointerstitial chronic inflammatory cells in progressive renal fibrosis after cancer therapies. Translational Research, 150 (1), 40-50. doi: 10.1016/j.trsl.2007.01.006
Qi, Weier, Johnson, David W., Vesey, David A., Pollock, Carol A. and Chen, Xinming (2007). Isolation, propagation and characterization of primary tubule cell culture from human kidney (Methods in Renal Research). Nephrology, 12 (2), 155-159. doi: 10.1111/j.1440-1797.2007.00779.x
Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney
Vesey, David A., Hooper, John D., Gobe, Glenda C. and Johnson, David W. (2007). Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney. Nephrology, 12 (1), 36-43. doi: 10.1111/j.1440-1797.2006.00746.x
Cheung, Catherine W., Vesey, David A., Nicol, David L. and Johnson, David W. (2007). Silibinin inhibits renal cell carcinoma via mechanisms that are independent if insulin-like growth factor-binding protein 3. BJU International, 99 (2), 454-460. doi: 10.1111/j.1464-410X.2007.06571.x
Novel renoprotective actions of erythropoietin: New uses for an old hormone
Johnson, David W., Forman, Colin and Vesey, David A. (2006). Novel renoprotective actions of erythropoietin: New uses for an old hormone. Nephrology, 11 (4), 306-312. doi: 10.1111/j.1440-1797.2006.00585.x
Johnson, D. W., Pat, B., Vesey, D. A., Guan, Z., Endre, Z. and Gobe, G. C. (2006). Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure. Kidney International, 69 (10), 1806-1813. doi: 10.1038/sj.ki.5000356
Vesey, David A., Cheung, Catherine W., Kruger, Wade A., Poronnik, Philip, Gobe, Glenda and Johnson, David W. (2005). Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells. Kidney International, 67 (4), 1315-1329. doi: 10.1111/j.1523-1755.2005.00209.x
Vesey, David A., Cheung, Catherine, Endre, Zoltan, Gobe, Glenda and Johnson, David W. (2005). Role of protein kinase C and oxidative stress in interleukin-1β-induced human proximal tubule cell injury and fibrogenesis. Nephrology, 10 (1), 73-80. doi: 10.1111/j.1440-1797.2005.00363.x
Cheung, Catherine, Vesey, David, Cotterill, Andrew, Douglas, Meaghan, Gobe, Glenda, Nicol, David and Johnson, David (2005). Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas. International Journal of Urology, 12 (1), 17-28. doi: 10.1111/j.1442-2042.2004.00993.x
Cheung, Catherine W., Vesey, David A., Nicol, David L. and Johnson, David W. (2004). The roles of IGF-I and IGFBP-3 in the regulation of proximal tubule, and renal cell carcinoma cell proliferation. Kidney International, 65 (4), 1272-1279. doi: 10.1111/j.1523-1755.2004.00535.x
Erythropoietin protects against ischaemic acute renal injury
Vesey, David A., Cheung, Catherine, Pat, Betty, Endre, Zoltan, Gobe, Glenda and Johnson, David W. (2004). Erythropoietin protects against ischaemic acute renal injury. Nephrology Dialysis Transplantation, 19 (2), 348-355. doi: 10.1093/ndt/gfg547
Vesey, David A., Cheung, Catherine, Cuttle, Leila, Endre, Zoltan, Gobe, Glenda and Johnson, David W. (2002). Interleukin-1 beta stimulates human renal fibroblast proliferation and matrix protein production by means of a transforming growth factor-beta-dependent mechanism. Journal of Laboratory And Clinical Medicine, 140 (5), 342-350. doi: 10.1067/mlc.2002.128468
Vesey, D. A., Cheung, C. W. Y., Cuttle, L., Endre, Z. A., Gobe, G. and Johnson, D. W. (2002). Interleukin-1 beta induces human proximal tubule cell injury, alpha-smooth muscle actin expression and fibronectin production. Kidney International, 62 (1), 31-40. doi: 10.1046/j.1523-1755.2002.00401.x
Johnson, D. W. and Vesey, D. A. (2002). Angiotensin converting enzyme inhibitors protect against renal injury via direct effects on the tubulointerstitium: evidence from cell cultures. Health Science, 11 (3), 14-15.
Human adipose tissue endothelial cells promote preadipocyte proliferation
Hutley, L. J., Herington, A. C., Shurety, W., Cheung, C., Vesey, D. A., Cameron, D. P. and Prins, J. B. (2001). Human adipose tissue endothelial cells promote preadipocyte proliferation. American Journal of Physiology - Endocrinology and Metabolism, 281 (5), E1037-E1044. doi: 10.1152/ajpendo.2001.281.5.E1037
Cannell, G. R., Vesey, D. A. and Dickinson, R. G. (2001). Inhibition of proliferation of HT-29 colon adenocarcinorna cells by carboxylate NSAIDs and their acyl glucuronides. Life Sciences, 70 (1), 37-48. doi: 10.1016/S0024-3205(01)01370-4
Johnson, D. W., Saunders, H. J., Vesey, D. A., Qi, W., Field, M. J. and Pollock, C. A. (2000). Enalaprilat directly ameliorates in vitro cyclosporin nephrotoxicity in human tubulo-interstitial cells. Nephron, 86 (4), 473-481. doi: 10.1159/000045837
Peritoneal homocysteine clearance is inefficient in peritoneal dialysis patients
Johnson, David W., Kay, Troy D., Vesey, David A., Isbel, Nicole, Campbell, Scott B. and Hawley, Carmel M. (2000). Peritoneal homocysteine clearance is inefficient in peritoneal dialysis patients. Peritoneal Dialysis International, 20 (6), 766-771.
Preparation and characterization of polyclonal antibodies against human chaperonin 10
Somodevilla-Torres, Maria J., Hillyard, Narelle C., Morton, Halle, Alewood, Dianne, Halliday, Judy A., Alewood, Paul F., Vesey, David A., Walsh, Michael D. and Cavanagh, Alice C. (2000). Preparation and characterization of polyclonal antibodies against human chaperonin 10. Cell Stress and Chaperones, 5 (1), 14-20. doi: 10.1379/1466-1268(2000)005<0014:PACOPA>2.0.CO;2
P53 Gene in Hepatocellular Carcinomas From Australia
Vesey, DA, Hayward, NK and Cooksley, Wge (1994). P53 Gene in Hepatocellular Carcinomas From Australia. Cancer Detection and Prevention, 18 (2), 123-130.
Vesey, DA, Selden, AC and Hodgson, Hjf (1993). Down-Regulation of Epidermal Growth-Factor Receptors in Liver Proliferation Induced by a Mixture of Triiodothyronine, Amino-Acids, Glucagon, and Heparin (tagh). Gut, 34 (11), 1601-1606. doi: 10.1136/gut.34.11.1601
Effect of Luminal Growth-Factor Preservation On Intestinal Growth
Playford, RJ, Woodman, AC, Clark, P, Watanapa, P, Vesey, D, Deprez, PH, Williamson, Rcn and Calam, J (1993). Effect of Luminal Growth-Factor Preservation On Intestinal Growth. Lancet, 341 (8849), 843-848. doi: 10.1016/0140-6736(93)93057-8
Galactosamine Induced Hepatitis Induces a Reduction in Hepatocyte Epidermal Growth-Factor Receptors
Vesey, DA, Woodman, AC and Hodgson, Hjf (1992). Galactosamine Induced Hepatitis Induces a Reduction in Hepatocyte Epidermal Growth-Factor Receptors. Gut, 33 (7), 954-958. doi: 10.1136/gut.33.7.954
Vesey, DA, Selden, AC, Woodman, AC and Hodgson, Hjf (1992). Effect of Invivo Administration of An Antibody to Epidermal Growth-Factor On the Rapid Increase in Dna-Synthesis Induced by Partial-Hepatectomy in the Rat. Gut, 33 (6), 831-835. doi: 10.1136/gut.33.6.831
Vesey, DA, Selden, AC and Hodgson, Hjf (1992). Comparative Effects of Epidermal Growth-Factor, An Insulin-Glucagon Combination, and a Hepatocyte Growth-Factor Preparation On Epidermal Growth-Factor Receptors. Journal of Hepatology, 15 (1-2), 107-113. doi: 10.1016/0168-8278(92)90020-P
Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol
Playford, RJ, Batten, JJ, Freeman, TC, Beardshall, K, Vesey, DA, Fenn, GC, Baron, JH and Calam, J (1991). Gastric Output of Pancreatic Secretory Trypsin-Inhibitor Is Increased by Misoprostol. Gut, 32 (11), 1396-1400. doi: 10.1136/gut.32.11.1396
Vesey, DA, Cunningham, JM, Selden, AC, Woodman, AC and Hodgson, Hjf (1991). Dimethyl-Sulfoxide Induces a Reduced Growth-Rate, Altered Cell Morphology and Increased Epidermal-Growth-Factor Binding in Hep G2 Cells. Biochemical Journal, 277 (3), 773-777. doi: 10.1042/bj2770773
Dose-Dependent Effects of Fentanyl On Indomethacin-Induced Gastric Damage
Playford, RJ, Vesey, DA, Haldane, S, Alison, MR and Calam, J (1991). Dose-Dependent Effects of Fentanyl On Indomethacin-Induced Gastric Damage. Digestion, 49 (4), 198-203. doi: 10.1159/000200722
Humphries, Tyrone, Dong, Xin, Watson, Julia, Mountford, Carolyn, Ellis, Robert, Vesey, David, Galloway, Graham, Gobe, Glenda and Francis, Ross (2023). Evaluating kidney fibrosis using in vivo 1h magnetic resonance spectroscopy in patients with chronic kidney disease and live donors. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4–6 September 2023. Richmond, VIC Australia: John Wiley & Sons.
Humphries, Tyrone, Gobe, Glenda, Urquhart, Aaron, Vesey, David, Ellis, Robert, Galloway, Graham and Francis, Ross (2023). Changes in energy metabolism in the kidney with tubulointerstitial fibrosis: an ex vivo whole tissue 2d-cosy approach. 60th ERA Congress, Milan, Italy, 15-18 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ndt/gfad063c_4344
Humphries, Tyrone, Gobe, Glenda, Urquhart, Aaron, Galloway, Graham, Vesey, David and Francis, Ross (2022). Identifying biochemical changes in the kidney using nuclear magnetic resonance in an adenine-diet chronic kidney disease mouse model. 57th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), 0nline, 17–19 October 2022. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14099
End-stage kidney disease following surgical management of kidney cancer in Queensland
Ellis, R., Edey, D., Del Vecchio, S., Mcstea, M., Hawley, C., Johnson, D., Vesey, D., Morais, C., Jordan, S., Francis, R., Wood, S. and Gobe, G. (2018). End-stage kidney disease following surgical management of kidney cancer in Queensland. 54th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, Australia, 8-12 September 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.13466
PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney
Han, Y., Ma, F., Ozols, E., Chew, P., Vesey, D., Gobe, G., Morais, C., Lohman, R., Suen, J., Fairlie, D. and Nikolic-Paterson, D. (2018). PAR-2 does not contribute to tubular damage or renal fibrosis in the obstructed kidney. 54th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, Australia, 8–12 September 2018. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.13441
Elevated serum creatinine and acute kidney injury following radical tumour nephrectomy
Ellis, R. J., Del Vecchio, S. J., Ng, K. L., Pascoe, E. M., Hawley, C. M., Johnson, D. W., Dimeski, G., Vesey, D. A., Coombes, J. S., Morais, C., Francis, R. S., Wood, S. T. and Gobe, G. C. (2017). Elevated serum creatinine and acute kidney injury following radical tumour nephrectomy. 53rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Darwin, NT Australia, 4-6 September 2017. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.13104
Raj, Ashok S., Holtmann, Gerald, Fletcher, Linda, Vesey, David A., Hickman, Ingrid J., Shanahan, Erin R., Tran, Cuong D. and Macdonald, Graeme (2016). Altered Proximal Small-Intestinal Permeability and Bacterial Translocation in Chronic Liver Disease in Relation to Hepatic Fibrosis and Disease Severity. 57th Annual Meeting and Residents Fellow Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), San Diego Ca, May 21-24, 2016. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. doi: 10.1016/S0016-5085(16)33950-6
Dheda, S., Min, H., Van, Eps C., Johnson, D., Vesey, D., Healy, H., Hawley, C. and Fahim, M. (2016). Inflammation in Dialysis. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, Western Australia, 17–21 September 2016. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1111/nep.12887
Ellis, R., Del Vecchio, S., Ng, K., Vesey, D., Francis, R., Wood, S. and Gobe, G. (2016). Kidney function following radical tumour nephrectomy. A comparison of functional outcomes by pre-operative CKD stage. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12888
Tesch, G., Han, Y., Vesey, D., Gobe, G., Lohman, R., Suen, J., Fairlie, D. and Nikolic-Paterson, D. (2016). Pharmacological Inhibition of Protease-Activated Receptor 2 (Par2) Reduces Crescent Formation in Rat Anti-Gbm Disease. 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth, WA, Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887
Owens, E., Iyer, A., Morais, C., Lohman, R., Suen, J., Johnson, D., Nikolic-Paterson, D., Gobe, G., Fairlie, D. and Vesey, D. (2016). Protease activated-receptor-2 induced inflammation and fibrosis is mediated in part through activation of transforming growth factor-beta signalling. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth Western Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887
Ellis, R. J., Small, D. M., Ng, K. L., Vesey, D. A., Vitetta, L., Francis, R., Morais, C. and Gobe, G. C. (2015). Indoxyl sulphate induces hypertrophy and impaired metabolic activity in cultured human proximal tubular cells. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543
Raj, A. S., Holtmann, G., Fletcher, L., Bhat, P., Tran, C., Black, M., Nath, K., Jao, W., Vesey, D. and Macdonald, G. A. (2015). Small intestinal permeability is elevated in chronic viral hepatitis prior to the development of cirrhosis, and is associated with the degree of fibrosis. 50th International Liver Congress of the European Association for the Study of the Liver, Vienna, Austria, 22-26 April, 2015. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/S0168-8278(15)30748-0
Ng, K. L., Wood, S. T., Ding, J. C., Jayasuriya, T. S., Vesey, D. A., Gobe, G. C. and Morais, C. (2014). Decreasing apoptosis repressor with caspase recruitment domain (ARC) is associated with disease progression and drug resistance of renal cell carcinoma. 67th Annual Scientific Meeting of the Urological-Society-of-Australia-and-New-Zealand, Brisbane, Australia, Mar 16-19, 2014. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.12618
Raj, Ashok, Holtmann, Gerald, Bhat, Purnima, Fletcher, Linda, Tran, Cuong, Vesey, David and Macdonald, Graeme (2014). Hepatic fibrosis is associated with small intestinal permeability in chronic liver disease due to hepatitis C, hepatitis B and non-alcoholic fatty liver disease, in subjects without ascites. A prospective cohort study using non-invasive techniques. Asian Pacific Digestive Week, Bali, Indonesia, 22‐25, 2014. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia . doi: 10.1111/jgh.12766_2
Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction
Ward, M. S., Flemming, N. B., Gallo, L. A., Fotheringham, A., Gobe, G., Vesey, D. and Forbes, J. M. (2014). Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301
Morais, C., Vesey, D., Johnson, D., Wood, S. and Gobe, G. (2013). Curcumin attenuates growth of established renal cell carcinoma through suppression of nuclear factor-kappa B. 49th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Brisbane, QLD Australia, 9-11 September 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12121
Morais, Christudas, Vesey, David A., Johnson, David W. and Gobe, Glenda C. (2013). Erythropoietin Delivered for Protection From Acute Kidney Injury May Have Secondary Benefits in Protecting Heart. 50th European Renal Association European Dialysis and Transplant Association Congress, Istanbul Turkey, 18-21 May 2013. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ndt/gft107
Rajandram, R., Gobe, G., Wang, Z., Vesey, D. A., Johnson, D. W. and Morais, C. (2012). Increasing anti-apoptotic nucleolar protein-3 correlates with cancer progression in renal cell carcinoma. 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Auckland, New Zealand, 27 - 29 August 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.
Corbier M, Bennett N, Whitbourne L, Roy S, Vesey DA and Gobe G (2011). Cadmium Toxicity To Proximal Tubular Epithelium Of The Kidney: Roles Of Inflammation And Mitochondrial Dysfunction. World Congress of Nephrology, Vancouver BC, Canada, April 8-12.
Boonprasert, K., Na-Bangchang, K., Gobe G. C. and Vesey D. A. (2011). Modulation of cytochrome P450, metallothionein and heme oxygenase-1 by cadmium in primary cultures of human proximal tubule cells. 47th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adealide, Australia, 19-21 September 2011. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2011.01490.x
Vesey David A., Suen, Jacky Yung, Johnson, David W. and Fairlie, David (2010). A Novel Protease-Activated Receptor-2 Antagonist Targeting Inflammation and Proliferation in Human Renal Tubular Epithelial Cells. Kidney Week, American society of Nephrology, Denver Colorado USA, November 16 - 21. Journal of the American Society of Nephrology:
Essential metals and cadmium toxicity in the kidney
Vesey, David (2010). Essential metals and cadmium toxicity in the kidney. Thailand Reverse Brain Drain Project International Conference on Cadmium in Food and Human Health, Phitsanulok, Thailand, 15-17 January 2010. Phitsanulok, Thailand: Naresuan University.
Protease-activated receptor-2 and renal carcinogenesis
Vesey, D., Rajandram, R., Blakeney, J., Suen, J., Johnson, D., Fairlie, D. and Gobe, G. (2010). Protease-activated receptor-2 and renal carcinogenesis. 46th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth Convention and Exhibition Centre, Perth, Western Australia, 12-15 September 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2010.01377_1.x
Functional significance of TRAF1 knockdown in renal cell carcinoma anti-cancer treatment
Gobe, Glenda C., Rajandram, Retnagowri, Vesey, David A., Wang, Zhiqiang, Bennett, Nigel and Johnson, David W. (2009). Functional significance of TRAF1 knockdown in renal cell carcinoma anti-cancer treatment. American Society of Nephrology Renal Week: 42nd Annual Meeting & Scientific Exposition, San Diego, CA, U.S.A., 27 October - 1 November, 2009. Washington , D.C., U.S.A.: American Society of Nephrology.
Gobe, Glenda C., Bennett, Nigel, Patel, Jatin, Colditz, Paul, Vesey, David A. and Johnson, David W. (2008). Modulation of vascular nestin and oxidant-induced endothelial injury by human recombinant erythropoietin in models of ischemic acute kidney injuryo-inflammatory and proliferative responses. Renal Week 2008: American Society of Nephrology Annual Meeting, Philadephia, USA, 14 - 19 November, 2008. Washington, D. C., USA: American Society of Nephrology.
Gobe, G. C., Yamada, M., Vesey, D. A. and Johnson, D. W. (2008). Recombinant human erythropoietin increases vascular expression of nestin and decreases oxidant-induced endothelial injury in models of ischemic acute kidney injury. 11th Asian-Pacific Congress of Nephrology, Kuala Lumpur, Malaysia, 5–8 May 2008. Carlton, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2008.00954.x
Gobe, G. C., Vesey, D. A., Bennett, N. C. and Johnson, D. W. (2008). Recombinant human erythropoietin reduces ischemic acute kidney injury but does not ameliorate progression to chronic kidney disease. 11th Asian Pacific Congress of Nephrology (APCN), Kuala Lumpur, Malaysia, 4-7 May 2008. Carlton, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2008.00953.x
Gobe, GC, Vesey, DA, Bennett, NC and Johnson, DW (2008). Recombinant human erythropoietin reduces ischemic acute kidney injury but does not ameliorate progression to chronic kidney disease. 11th Asian Pacific Congress of Nephrology, incorporating the 15th Asian Colloquium in Nephrology and 2nd Asian Forum of CKD Initiative, Kuala Lumpur, Malaysia, 5–8 May 2008. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2008.00953.x
Bennett, N., Colditz, P., Gobe, G. C., Johnson, D., Patel, J. and Vesey, D. A. (2008). Recombinant human erythropoietin reduces ischemic acute kidney injury but does not stop progression to chronic kidney disease. 44th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Newcastle, Australia, 6-10 September 2008. HOBOKEN: Australian and New Zealand Society of Nephrology (ANZSN). doi: 10.1111/j.1440-1797.2008.001013.x
Erythropoietin: Novel applications beyond anaemia treatment
Vesey, D. A., Gobe, G. C. and Johnson, D. W. (2007). Erythropoietin: Novel applications beyond anaemia treatment. 2nd International Conference of Naresuan University, Phitsanulok, Thailand, 27-28 July, 2007.
The effect of recombinant human erythropoietin (rhEPO) in renal cell carcinoma (RCC) chemotherapy
Li, J., Vesey, D. A., Johnson, D. W. and Gobe, G. C. (2007). The effect of recombinant human erythropoietin (rhEPO) in renal cell carcinoma (RCC) chemotherapy. 32nd Lorne Conference on Protein Structure and Function, Lorne, Victoria, Australia, 4-8 February 2007. Lorne, Vic., Australia:
The effect of recombinant human erythropoietin (rhEPO) in renal cell carcinoma (RCC) chemotherapy
Li, J., Vesey, D. A., Johnson, D. W. and Gobe, G. C. (2007). The effect of recombinant human erythropoietin (rhEPO) in renal cell carcinoma (RCC) chemotherapy. World Congress of Nephrology, Rio De Janeiro, Brazil, 21-25 April , 2007. International Society of Nephrology (ISN).
Gobe, G. C., Johnson, D. W., Kruger, W., Poronnik, P. and Vesey, D. A. (2006). PAR-2 Is expressed by human proximal tubule cells and mediates pro-inflammatory and proliferative responses. Renal Week 2006: American Society of Nephrology Annual Meeting, San Diego, California, U.S., 14 - 19 November, 2006. American Society of Nephrology.
Li, J., Vesey, D. and Gobe, G. (2006). PKC regulation of the cyclin dependent kinase (cdk) inhibitor p21 in normal kidney versus kidney cancer cells. Australia and New Zealand Society of Nephrology and Renal Society of Australasia Annual Scientific Conference, Melbourne, Australia, 14–19 August 2006.
Li, Jun, Vesey, David and Gobe, Glenda (2006). PKC regulation of the cyclin dependent kinase inhibitor p21 in normal kidney versus kidney cancer cells. American Society of Nephrology Renal Research Week, San Diego, USA, 2006. ASN.
Yamada, M., Vesey, D., Johnson, D. W. and Gobe, G. (2006). Protective effect of Angelica sinensis on renal vascular endothelial cell damage induced by oxidative stress. ANZSN 2006: 42nd Australia and New Zealand Society of Nephrology and Renal Society of Australasia Annual Scientific Conference, Melbourne, Australia, 14-19 August 2006. Carlton, Vic., Australia: Blackwell Science. doi: 10.1111/j.1440-1797.2006.00656.x
Resistance to cancer treatments in renal cell carcinomas: Discovering novel apoptotic pathways
Rajandram, R ., Pat, B., Li, J., Percy, C. J., Vesey, D., Johnson, D. W. and Gobe, G. C. (2006). Resistance to cancer treatments in renal cell carcinomas: Discovering novel apoptotic pathways. Australian and New Zealand Society of Nephrology Annual Scientific Meeting, Melbourne, Australia, 14-18 August 2006. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1797.2006.00656.x
Cell death in the renal vascular endothelium: An analysis of cytoprotection by erythropoietin
Gobe, G., Yamada, M., Pat, B., Vesey, D. and Johnson, D. W. (2005). Cell death in the renal vascular endothelium: An analysis of cytoprotection by erythropoietin. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Wellington, New Zealand, 3-7 September 2005. Carlton, Vic.: Blackwell Science. doi: 10.1111/j.1440-1797.2005.00461.x
Cell death in the renal vascular endothelium: an analysis of cytoprotection by erythropoietin
Yamada, M., Pat, B., Vesey, D., Johnson, D. and Gobe, G. (2005). Cell death in the renal vascular endothelium: an analysis of cytoprotection by erythropoietin. 5th Annual Health and Medical Research Conference of Queensland, Brisbane, Queensland, 3-4 November 2005.
Johnson, D., Pat, B., Vesey, D., Guan, Z., Endre, Z. and Gobe, G. (2005). Delayed bolus administration of darbepoietin or erythropoietin protects against ischaemic acute renal injury and failure. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Wellington, New Zealand, 3-7 September 2005. Carlton, Vic.: Blackwell Science. doi: 10.1111/j.1440-1797.2005.00461.x
Vesey, D., Kruger, W., Poronnik, P., Gobe, G. and Johnson, D. (2005). PAR-2 activation promotes cortical fibroblast proliferation and matrix protein production: A potential role for locally expressed trypsinogen. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Wellington, New Zealand, 3-7 September 2005. Carlton, Vic.: Blackwell Science. doi: 10.1111/j.1440-1797.2005.00461.x
Resistance to cancer treatments in renal cell carcinoma: Discovering novel apoptosis pathways
Rajandram, R., Pat, B., Li, J., Percy, C., Vesey, D., Johnson, D. W. and Gobe, G. (2005). Resistance to cancer treatments in renal cell carcinoma: Discovering novel apoptosis pathways. 5th Annual Health and Medical Research Conference of Queensland, Brisbane, Queensland, 3-4 November, 2005. Brisbane, Queensland: Queensland Health.
Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas
Gobe, G., Li, J., Pat, B., Yan, J., Vesey, D., Johnson, D. and Nicol, D. (2005). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, 4-8 September 2005, Carlton, Victoria. Blackwell Science: 1320-5358 (print); 1440-1797 (electronic). doi: 10.1111/j.1440-1797.2005.00461.x
The role of JAK tyrosine kinases in renal fibrosis involving oxidative stress
Pat, B., Healy, H., Vesey, D. A., Johnson, D. W. and Gobe, G. C. (2005). The role of JAK tyrosine kinases in renal fibrosis involving oxidative stress. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Wellington, New Zealand, 3–7 September 2005. Carlton, VIC: Blackwell Science. doi: 10.1111/j.1440-1797.2005.00461.x
Vesey, D., Cheung, C., Taylor, P., Kirkpatirick, C., Gobe, G., Winterford, C., Nicol, D. and Johnson, D. (2005). Therapeutic value of orally administered silibinin in renal cell carcinoma: Manipulation of IGFBP-3 levels. 41st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Wellington, New Zealand, 3-7 September 2005. Carlton, Victoria: Blackwell Science. doi: 10.1111/j.1440-1797.2005.00461.x
Li, J., Pat, B., Yang, T., Vesey, D., Johnson, D. W. and Gobe, G. C. (2004). Chemotherapy induced apoptosis in renal carcinomas versus normal renal tubular epithelium: Role of PKCs. 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adelaide Convention Centre, Adelaide, Australia, 1–3 September, 2004. Carlton, Vic. Australia: Blackwell Science. doi: 10.1111/j.1440-1797.2004.00264.x
Vesey, D. A., Cheung, C. W., Kruger, W., Poronnik, P., Gobé, G. C. and Johnson, D. W. (2004). Par-2 activation mediates pro-inflammatory and proliferative responses in renal proximal tubule cells. 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adelaide Convention Centre, Adelaide, Australia, 1–3 September, 2004. Carlton, Vic. Australia: Blackwell Science. doi: 10.1111/j.1440-1797.2004.00264.x
Cheung, C. W., Vesey, D. A., Nicol, D. L. and Johnson, D. W. (2004). Silibinin inhibits renal cell carcinoma cell growth via an insulin-like growth factor (IGFBP-3) independent pathway. 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adelaide Convention Centre, Adelaide, Australia, 1–3 September, 2004. Carlton, Vic. Australia: Blackwell Science. doi: 10.1111/j.1440-1797.2004.00264.x
Vesey, D. A., Cheung, C. W., Gobe, G. C. and Johnson, D. W. (2003). Activation of protease-activated receptors (PAR) on cultured human proximal tubular cells (PAR) mediates inflammatory and fibroproliferative responses. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, W. A., 31 August- 3 September, 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
Cheung, C. W., Vesey, D. A., Nicol, D. L. and Johnson, D. W. (2003). Renal cell carcinoma growth is regulated by autocrine insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) action. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, Australia, 31 August - 3 September 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
Cheung, Catherine, Vesey, David, Nicol, David and Johnson, David (2003). Renal cell carcinoma growth is regulated by autocrine insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) action. The World Congress of Nephrology, Berlin, Germany, 8-12 June, 2003. Oxford, England: Oxford University Press.
Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas
Li, J., Pat, B., Yan, J., Vesey, D. A., Johnson, D. W., Nicol, D. and Gobe, G. C. (2003). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, WA, Australia, 31 August- 3 September, 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
Vesey, D. A., Cheung, C. W., Gobe, G. C. and Johnson, D. W. (2003). Thrombin stimulates inflammatory and fibro-proliferative responses in cultured human proximal tubule cells. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, W. A., 31 August- 3 September, 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
Vesey, D. A., Cheung, C., Gobe, G. and Johnson, D. W. (2003). Thrombin stimulates pro-inflammatory and fibro-proliferative response in cultured human proximal tubule cells. Annual Queensland Health and Medical Scientific Meeting, Brisbane, Qld, Australia, 25-26 November, 2003. Brisbane, Qld, Australia: Queensland Health.
Insulin-like growth factor (IGF)-I stimulates in vitro human renal cell carcinoma (RCC) growth
Cheung, C., Vesey, D. A., Gobe, G., Nicol, D. L. and Johnson, D. W. (2002). Insulin-like growth factor (IGF)-I stimulates in vitro human renal cell carcinoma (RCC) growth. Australian and New Zealand Society of Nephrology 37th Annual Scientific Meeting, Darwin, Australia, 5-7 September, 2001. Carlton, Vic.: Blackwell Science. doi: 10.1046/j.1440-1797.2002.00007-1-15.x
Vesey, D. A., Cheung, C., Gobe, G., Endre, Z. and Johnson, D. W. (2001). Interleukin-1B (IL-1B) stimulates human renal cortical fibroblast (CF) DNA synthesis and extracellular matrix production through a transforming growth factor-beta (TGFB) dependent mechanism. 37th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Darwin, NT, 5th - 7th September, 2001. Carlton, VIC: Blackwell Science. doi: 10.1046/j.1440-1797.2002.00007-1-140.x
Vesey, D. A., Cheung, C., Endre, Z. H., Gobe, G. C. and Johnson, D. W. (2000). Cyclosporin (CyA) promotes human renal cortical fibroblast (CF) toxicity, extracellular matrix deposition and nitric oxide (NO) release. ANZSN Annual Scientific Meeting, Melbourne, 15-17 Mar, 2000.
Vesey, D. A., Cheung, C., Endre, Z. H., Gobe, G. C. and Johnson, D. W. (2000). Interleukin-1b (IL-1b). ANZSN Annual Scientific Meeting, Melbourne, Vic, 15-17 Mar, 2000. Sydney: Australian & New Zealand Society of Nephrology.
(2013–2015) UQ Academic Title Holder Research Fund
Enhancing erythropoietin therapy in ischaemia-reperfusion injury of heart and kidney
(2010–2013) NHMRC Project Grant
Protease activated receptor 2 antagonist in inflammatory disease
(2010–2012) NHMRC Development Grant
Protease Activated Receptor 2 : A New Drug Target For Inflammatory Diseases and Cancer
(2009–2012) NHMRC Project Grant
Exploring magnetic resonance for differentiating between progressive and non-progressive chronic kidney disease
Doctor Philosophy — Associate Advisor
Other advisors:
Clinical Biobanking and the Distinguishing Risk of Progressive Chronic Kidney Disease Study
(2021) Doctor Philosophy — Associate Advisor
Other advisors:
Exploring Resistance of Renal Cell Carcinoma to Sunitinib Therapy
(2020) Doctor Philosophy — Associate Advisor
The role of the adipose tissue microenvironment in kidney cancer
(2020) Doctor Philosophy — Associate Advisor
Other advisors:
Bioactive compounds from Australian Blacklip Abalone (Haliotis rubra) processing waste
(2016) Doctor Philosophy — Associate Advisor
Targeting genes for identification and treatment of renal cell carcinoma
(2009) Doctor Philosophy — Associate Advisor
Other advisors: