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Protease Activated Receptor 2 : A New Drug Target For Inflammatory Diseases and Cancer (2009–2012)

Abstract:
A new class of proteins (Protease Activated Receptors) has been found on the surfaces of many different types of cells. They are believed to be natural sensors that respond to traces of degradative enzymes called proteases. This project will create and evaluate new drugs for one of these receptors thought to regulate inflammatory diseases (e.g. arthritis, inflammatory bowel disease, asthma, pancreatitis) and cancers, while providing a better understanding of a new mechanism of immune defence.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience

  • Associate Professor David Vesey

    ATH - Associate Professor
    Princess Alexandra Hospital Southside Clinical Unit
    Faculty of Medicine
Funded by:
National Health and Medical Research Council