The University of Queensland

Cell line isolation and design

Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2019). Cell line isolation and design. Comprehensive biotechnology. (pp. 144-153) edited by Murray Moo-Young. Oxford, United Kingdom: Pergamon. doi: 10.1016/B978-0-444-64046-8.00013-6

An optimised transfection platform for the Epi-CHO transient expression system in serum-free media

Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2012). An optimised transfection platform for the Epi-CHO transient expression system in serum-free media. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 19-23) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_3

Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination

Hou, Jeff Jia Cheng, Song, Michael, Munro, Trent P. and Gray, Peter P. (2012). Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. (pp. 47-51) edited by Nigel Jenkins, Niall Barron and Paula Alves. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-0884-6_8

Cell line isolation and design

Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2011). Cell line isolation and design. Scientific Fundamentals of Biotechnology. (pp. 169-178) edited by Murray Moo-Young, Michael Butler, Colin Webb, Antonio Moreira,, Bernard Grodzinski, Z. F. Cui and Spiros Agathos. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-08-088504-9.00024-6

Anticipatory regulation for pandemic responses: are we there yet?

Oyola-Lozada, Maria Giuliana, Pregelj, Lisette, Jenkins, Anna, Siegel, Evan, Munro, Trent and Hine, Damian (2024). Anticipatory regulation for pandemic responses: are we there yet?. Trends in Biotechnology. doi: 10.1016/j.tibtech.2024.02.016

Are manufacturing patents to blame for biosimilar market launch delays?

Williamson, Rhys, Munro, Trent, Ascher, David, Robertson, Avril and Pregelj, Lisette (2024). Are manufacturing patents to blame for biosimilar market launch delays?. Value in Health, 27 (3), 287-293. doi: 10.1016/j.jval.2023.12.005

Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells

Martínez, Verónica S., Rodriguez, Karen, McCubbin, Timothy, Tong, Junjie, Mahler, Stephen, Shave, Evan, Baker, Kym, Munro, Trent P. and Marcellin, Esteban (2024). Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells. Biotechnology Journal, 19 (2) ARTN e2300338, e2300338. doi: 10.1002/biot.202300338

Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation

Nöbel, Matthias, Barry, Craig, MacDonald, Michael A., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Martínez, Verónica S., Nielsen, Lars K. and Marcellin, Esteban (2023). Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation. Biotechnology and Bioengineering, 121 (4), 1371-1383. doi: 10.1002/bit.28613

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842, 104842. doi: 10.1016/j.ebiom.2023.104842

mRNA vaccine quality analysis using RNA sequencing

Gunter, Helen M., Idrisoglu, Senel, Singh, Swati, Han, Dae Jong, Ariens, Emily, Peters, Jonathan R., Wong, Ted, Cheetham, Seth W., Xu, Jun, Rai, Subash Kumar, Feldman, Robert, Herbert, Andy, Marcellin, Esteban, Tropee, Romain, Munro, Trent and Mercer, Tim R. (2023). mRNA vaccine quality analysis using RNA sequencing. Nature Communications, 14 (1) 5663, 1-12. doi: 10.1038/s41467-023-41354-y

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085

Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine

Deliyannis, Georgia, Gherardin, Nicholas A., Wong, Chinn Yi, Grimley, Samantha L., Cooney, James P., Redmond, Samuel J., Ellenberg, Paula, Davidson, Kathryn C., Mordant, Francesca L., Smith, Tim, Gillard, Marianne, Lopez, Ester, McAuley, Julie, Tan, Chee Wah, Wang, Jing J., Zeng, Weiguang, Littlejohn, Mason, Zhou, Runhong, Fuk-Woo Chan, Jasper, Chen, Zhi-wei, Hartwig, Airn E., Bowen, Richard, Mackenzie, Jason M., Vincan, Elizabeth, Torresi, Joseph, Kedzierska, Katherine, Pouton, Colin W., Gordon, Tom P., Wang, Lin-fa ... Godfrey, Dale I. (2023). Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine. eBioMedicine, 92 104574, 104574. doi: 10.1016/j.ebiom.2023.104574

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study

Kouli, O., Murray, V., Bhatia, S., Cambridge, W. A., Kawka, M., Shafi, S., Knight, S. R., Kamarajah, S. K., McLean, K. A., Glasbey, J. C., Khaw, R. A., Ahmed, W., Akhbari, M., Baker, D., Borakati, A., Mills, E., Thavayogan, R., Yasin, I., Raubenheimer, K., Ridley, W., Sarrami, M., Zhang, G., Egoroff, N., Pockney, P., Richards, T., Bhangu, A., Creagh-Brown, B., Edwards, M., Harrison, E. M. ... Wischhusen, S. (2022). Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study. The Lancet Digital Health, 4 (7), e520-e531. doi: 10.1016/S2589-7500(22)00069-3

Engineering death resistance in CHO cells for improved perfusion culture

MacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K. and Marcellin, Esteban (2022). Engineering death resistance in CHO cells for improved perfusion culture. mAbs, 14 (1) e2083465, 1-13. doi: 10.1080/19420862.2022.2083465

Design and production strategies for developing a recombinant butyrylcholinesterase medical countermeasure for Organophosphorus poisoning

Allard, Joanne L., Shields, Katherine A., Munro, Trent P. and Lua, Linda H.L. (2022). Design and production strategies for developing a recombinant butyrylcholinesterase medical countermeasure for Organophosphorus poisoning. Chemico-Biological Interactions, 363 109996, 109996. doi: 10.1016/j.cbi.2022.109996

The potential of long noncoding RNA therapies

Mercer, Tim R., Munro, Trent and Mattick, John S. (2022). The potential of long noncoding RNA therapies. Trends in Pharmacological Sciences, 43 (4), 269-280. doi: 10.1016/j.tips.2022.01.008

A call to action for translational sciences in COVID-19 and future pandemics

Wan, Kanny K., Davis, Danielle, Lee, Taylor N., Ford-Scheimer, Stephanie L., Andreu, Antonio L., Bietrix, Florence, Bryans, Justin, Castro, Marco T., Chiba, Nobuyoshi, Faupel-Badger, Jessica M., Haynes, Brittany, Hirasawa, Ryutaro, Morel, Carlos M., Souza, Thiago Moreno L., Morrow, David, Munro, Trent, Newman, Stuart, Ussi, Anton E., Zorzal, Poliana B., Hall, Matthew D., Lo, Donald C. and Cutillo, Christine M. (2022). A call to action for translational sciences in COVID-19 and future pandemics. Nature Reviews Drug Discovery, 21 (3), 165-166. doi: 10.1038/d41573-022-00020-6

Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok

MacDonald, Michael A., Barry, Craig, Groves, Teddy, Martínez, Verónica S., Gray, Peter P., Baker, Kym, Shave, Evan, Mahler, Stephen, Munro, Trent, Marcellin, Esteban and Nielsen, Lars K. (2022). Modelling apoptosis resistance in CHO cells with CRISPR‐mediated knock‐outs of Bak1, Bax, and Bok. Biotechnology and Bioengineering, 119 (6), 1380-1391. doi: 10.1002/bit.28062

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0

Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer

He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L., Goh, Justin B., Lyons, Nicholas J., Pearce, Lesley A., Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M,, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C., Perrin, Lewis C., Williams, Charlotte C., Puttick, Simon, Adams, Timothy E., Munro, Trent P., Hooper, John D. and Chetty, Naven (2021). Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer. Molecular Pharmaceutics, 18 (9) acs.molpharmaceut.1c00401, 3464-3474. doi: 10.1021/acs.molpharmaceut.1c00401

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel, Wijesundara, Danushka K., Modhiran, Naphak, Mordant, Francesca L., Li, Zheyi, Avumegah, Michael S., McMillan, Christopher L. D., Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey T. M., Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L., Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam ... Chappell, Keith J. (2021). Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clinical & Translational Immunology, 10 (4) e1269, e1269. doi: 10.1002/cti2.1269

First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2

Chappell, Keith Joseph, Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia, Cheung, Stacey, Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Bennet, Jillian, Hensen, Luca, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., AW, Chung, Tran, Mai H., Tapley, Peter, Reading, Patrick, Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P. Mark, Kedzierska, Katherine, Purcell, Damian, Ranasinghe, Charani, Subbarao, Kanta ... Munro, Trent P. (2021). First report of a phase 1 randomised trial of molecular clamp-stabilised spike protein-based and MF59-adjuvanted vaccine for SARS-CoV-2. SSRN Electronic Journal. doi: 10.2139/ssrn.3769210

Mutational and biophysical robustness in a prestabilized monobody

Chandler, Peter G., Tan, Li Lynn, Porebski, Benjamin T., Green, James S., Riley, Blake T., Broendum, Sebastian S., Hoke, David E., Falconer, Robert J., Munro, Trent P., Buckle, Malcolm, Jackson, Colin J. and Buckle, Ashley M. (2021). Mutational and biophysical robustness in a prestabilized monobody. Journal of Biological Chemistry, 296 100447, 100447. doi: 10.1016/j.jbc.2021.100447

Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

MacDonald, Michael A., Nöbel, Matthias, Roche Recinos, Dinora, Martínez, Verónica S., Schulz, Benjamin L., Howard, Christopher B., Baker, Kym, Shave, Evan, Lee, Yih Yean, Marcellin, Esteban, Mahler, Stephen, Nielsen, Lars Keld and Munro, Trent (2021). Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications. Critical Reviews in Biotechnology, 42 (7), 1-17. doi: 10.1080/07388551.2021.1998821

Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study

Playford, Elliott Geoffrey, Munro, Trent, Mahler, Stephen M., Elliott, Suzanne, Gerometta, Michael, Hoger, Kym L., Jones, Martina L., Griffin, Paul, Lynch, Kathleen D., Carroll, Heidi, El Saadi, Debra, Gilmour, Margaret E., Hughes, Benjamin, Hughes, Karen, Huang, Edwin, de Bakker, Christopher, Klein, Reuben, Scher, Mark G., Smith, Ina L., Wang, Lin-Fa, Lambert, Stephen B., Dimitrov, Dimiter S., Gray, Peter P. and Broder, Christopher C. (2020). Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study. The Lancet Infectious Diseases, 20 (4), 445-454. doi: 10.1016/S1473-3099(19)30634-6

Working hard or hardly working? Regulatory bottlenecks in developing a COVID-19 vaccine

Pregelj, Lisette, Hine, Damian C., Oyola-Lozada, Maria G. and Munro, Trent P. (2020). Working hard or hardly working? Regulatory bottlenecks in developing a COVID-19 vaccine. Trends in Biotechnology, 38 (9), 943-947. doi: 10.1016/j.tibtech.2020.06.004

Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring

Jorgolli, Marsela, Nevill, Tanner, Winters, Aaron, Chen, Irwin, Chong, Su, Lin, Fen-Fen, Mock, Marissa, Chen, Ching, Le, Kim, Tan, Christopher, Jess, Philip, Xu, Han, Hamburger, Agi, Stevens, Jennitte, Munro, Trent, Wu, Ming, Tagari, Philip and Miranda, Les P. (2019). Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. Biotechnology and Bioengineering, 116 (9), 2393-2411. doi: 10.1002/bit.27024

Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a randomised, first-in-human phase 1 study

Playford, Elliott, Munro, Trent, Mahler, Stephen M., Elliott, Suzanne, Gerometta, Michael, Hoger, Kym L., Jones, Martina L., Griffin, Paul, Lynch, Kathleen D., Carroll, Heidi, El Saadi, Debra, Gilmour, Margaret E., Hughes, Benjamin, Hughes, Karen, Huang, Edwin, de Bakker, Christopher, Klein, Reuben, Scher, Mark G., Smith, Ina L., Wang, Lin-Fa, Lambert, Stephen B., Dimitrov, Dimiter S., Gray, Peter P. and Broder, Christopher C. (2019). Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a randomised, first-in-human phase 1 study. SSRN Electronic Journal. doi: 10.2139/ssrn.3457427

A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology

Le, Kim, Tan, Christopher, Gupta, Shivani, Guhan, Trupti, Barkhordarian, Hedieh, Lull, Jonathan, Stevens, Jennitte and Munro, Trent (2018). A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology. Biotechnology Progress, 34 (6), 1438-1446. doi: 10.1002/btpr.2690

Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line

Tharmalingam, Tharmala, Barkhordarian, Hedieh, Tejeda, Nicole, Daris, Kristi, Yaghmour, Sam, Yam, Pheng, Lu, Fang, Goudar, Chetan, Munro, Trent and Stevens, Jennitte (2018). Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line. Biotechnology Progress, 34 (3), 613-623. doi: 10.1002/btpr.2666

RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cells

Orellana, Camila A., Marcellin, Esteban, Palfreyman, Robin W., Munro, Trent P., Gray, Peter P. and Nielsen, Lars K. (2018). RNA-seq highlights high clonal variation in monoclonal antibody producing CHO cells. Biotechnology Journal, 13 (3) 1700231, e1700231. doi: 10.1002/biot.201700231

Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies

Munro, Trent P., Le, Kim, Le, Huong, Zhang, Li, Stevens, Jennitte, Soice, Neil, Benchaar, Sabrina A., Hong, Robert W. and Goudar, Chetan T. (2017). Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies. Biotechnology Progress, 33 (6), 1476-1482. doi: 10.1002/btpr.2572

Introduction to special section on using pools to generate Good Laboratory Practice tox or other non-clinical material to accelerate development timelines

DeMaria, Christine and Munro, Trent (2017). Introduction to special section on using pools to generate Good Laboratory Practice tox or other non-clinical material to accelerate development timelines. Biotechnology Progress, 33 (6), 1435-1435. doi: 10.1002/btpr.2583

Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines

Frye, Christopher, Deshpande, Rohini, Estes, Scott, Francissen, Kathy, Joly, John, Lubiniecki, Anthony, Munro, Trent, Russell, Reb, Wang, Tongtong and Anderson, Karin (2016). Industry view on the relative importance of "clonality" of biopharmaceutical-producing cell lines. Biologicals, 44 (2), 117-122. doi: 10.1016/j.biologicals.2016.01.001

Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.

Seldon, T. A., Pryor, R., Palkova, A., Jones, M. L., Verma, N. D., Findova, M., Braet, K., Sheng, Y., Fan, Y., Zhou, Y. Y., Marks, J. D., Munro, T., Mahler, S. M., Barnard, R. T., Fromm, P. D., Silveira, P. A., Elgundi, Z., Ju, X., Clark, G. J., Bradstock, K. F., Munster, D. J. and Hart, D. N. J. (2015). Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.. Leukemia, 30 (3), 692-700. doi: 10.1038/leu.2015.231

Nanocell targeting using engineered bispecific antibodies.

Taylor, Karin, Howard, Christopher B., Jones, Martina L., Sedliarou, Ilya, MacDiarmid, Jennifer, Brahmbhatt, Himanshu, Munro, Trent P. and Mahler, Stephen M. (2014). Nanocell targeting using engineered bispecific antibodies.. mAbs, 7 (1), 53-65. doi: 10.4161/19420862.2014.985952

Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers

Gillard, Marianne, Jia, Zhongfan, Hou, Jeff Jia Cheng, Song, Michael, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Intracellular trafficking pathways for nuclear delivery of plasmid DNA complexed with highly efficient endosome escape polymers. Biomacromolecules, 15 (10), 3569-3576. doi: 10.1021/bm5008376

An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer

Goodall, Stephen, Howard, Christopher B., Jones, Martina L., Munro,Trent, Jia, Zhongfan, Monteiro, Michael J and Mahler, Stephen (2014). An EGFR targeting nanoparticle self assembled from a thermoresponsive polymer. Journal of Chemical Technology and Biotechnology, 90 (7), 1222-1229. doi: 10.1002/jctb.4509

Timed-release polymers as novel transfection reagents

Gillard, Marianne, Jia, Zhongfan, Gray, Peter P., Munro, Trent P. and Monteiro, Michael J. (2014). Timed-release polymers as novel transfection reagents. Polymer Chemistry, 5 (10), 3372-3378. doi: 10.1039/c4py00176a

High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system

Hou, Jeff Jia Cheng, Hughes, Ben S., Smede, Matthew, Leung, Kar Man, Levine, Kara, Rigby, Susan, Gray, Peter P. and Munro, Trent P. (2014). High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system. New Biotechnology, 31 (3), 214-220. doi: 10.1016/j.nbt.2014.02.002

Thermoresponsive worms for expansion and release of human embryonic stem cells

Chen, Xiaoli, Prowse, Andrew B. J., Jia, Zhongfan, Tellier, Helena, Munro,Trent P., Gray, Peter P. and Monteiro, Michael J. (2014). Thermoresponsive worms for expansion and release of human embryonic stem cells. Biomacromolecules, 15 (3), 844-855. doi: 10.1021/bm401702h

Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels

Menzies, Donna J., Cameron, Andrew, Munro, Trent, Wolvetang, Ernst, Grondahl, Lisbeth and Cooper-White, Justin J. (2013). Tailorable cell culture platforms from enzymatically cross-linked multifunctional poly(ethylene glycol)-based hydrogels. Biomacromolecules, 14 (2), 413-423. doi: 10.1021/bm301652q

Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro

Prowse, Andrew B. J., Chong, Fenny, Elliott, David A., Elefanty, Andrew G., Stanley, Edouard G., Gray, Peter P., Munro, Trent P. and Osborne, Geoffrey W. (2012). Analysis of Mitochondrial Function and Localisation during Human Embryonic Stem Cell Differentiation In Vitro. PLoS One, 7 (12) e52214, e52214-1-e52214-10. doi: 10.1371/journal.pone.0052214

Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media

Zhu, Jiang, Wooh, Jong Wei, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2012). Recombinant human albumin supports single cell cloning of CHO cells in chemically defined media. Biotechnology Progress, 28 (3), 887-891. doi: 10.1002/btpr.1549

Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates

Munro, Trent P., Mahler, Stephen M., Huang, Edwin P., Chin, David Y. and Gray, Peter P. (2011). Bridging the gap: Facilities and technologies for development of early stage therapeutic mAb candidates. mAbs, 3 (5), 440-452. doi: 10.4161/mabs.3.5.16968

Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1

Codamo, Joe, Hou, Jeff Jia Cheng, Hughes, Benjamin S., Gray, Peter P. and Munro, Trent P. (2011). Efficient mAb production in CHO cells incorporating PEI-mediated transfection, mild hypothermia and the co-expression of XBP-1. Journal of Chemical Technology and Biotechnology, 86 (7), 923-934. doi: 10.1002/jctb.2572

New frontiers in cell line development: Challenges for biosimilars

Hou, Jeff Jia Cheng, Codamo, Joe, Pilbrough, Warren, Hughes, Benjamin, Gray, Peter P. and Munro, Trent P. (2011). New frontiers in cell line development: Challenges for biosimilars. Journal of Chemical Technology and Biotechnology, 86 (7), 895-904. doi: 10.1002/jctb.2574

Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients

Falconer, Robert J., Chan, Cherrine, Hughes, Karen and Munro, Trent P. (2011). Stabilization of a monoclonal antibody during purification and formulation by addition of basic amino acid excipients. Journal of Chemical Technology and Biotechnology, 86 (7), 942-948. doi: 10.1002/jctb.2657

Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system

Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2011). Enhanced CHO cell-based transient gene expression with the Epi-CHO expression system. Molecular Biotechnology, 48 (2), 109-115. doi: 10.1007/s12033-010-9351-9

Stem cell integrins: Implications for ex-vivo culture and cellular therapies

Prowse, Andrew B. J., Chong, Fenny, Gray, Peter P. and Munro, Trent P. (2011). Stem cell integrins: Implications for ex-vivo culture and cellular therapies. Stem Cell Research, 6 (1), 1-12. doi: 10.1016/j.scr.2010.09.005

Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media

Prowse, Andrew B. J., Doran, Michael R., Cooper-White, Justin J., Chong, Fenny, Munro, Trent P., Fitzpatrick, Jane, Chung, Tung-Liang, Haylock, David N., Gray, Peter P. and Wolvetang, Ernst J. (2010). Long term culture of human embryonic stem cells on recombinant vitronectin in ascorbate free media. Biomaterials, 31 (32), 8281-8288. doi: 10.1016/j.biomaterials.2010.07.037

Defined high protein content surfaces for stem cell culture

Doran, Michael R., Frith, Jessica E., Prowse, Andrew B. J., Fitzpatrick, Jane, Wolvetang, Ernst J., Munro, Trent P., Gray, Peter P. and Cooper-White, Justin J. (2010). Defined high protein content surfaces for stem cell culture. Biomaterials, 31 (19), 5137-5142. doi: 10.1016/j.biomaterials.2010.03.015

A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies

Jones, Martina L., Seldon, Therese, Smede, Matthew, Linville, Ashleigh, Chin, David Y., Barnard, Ross, Mahler, Stephen M., Munster, David, Hart, Derek, Gray, Peter P. and Munro, Trent P. (2010). A method for rapid, ligation-independent reformatting of recombinant monoclonal antibodies. Journal of Immunological Methods, 354 (1-2), 85-90. doi: 10.1016/j.jim.2010.02.001

Controlled presentation of recombinant proteins via a zinc-binding peptide-linker in two and three dimensional formats

Doran, M.R., Markway, B.D., Croll, T.I., Sara, S., Munro, T.P. and Cooper-White, J.J. (2009). Controlled presentation of recombinant proteins via a zinc-binding peptide-linker in two and three dimensional formats. BIOMATERIALS, 30 (34), 6614-6620. doi: 10.1016/j.biomaterials.2009.08.033

Intraclonal protein expression heterogeneity in recombinant CHO cells

Pilbrough, Warren, Munro, Trent P. and Gray, Peter (2009). Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS One, 4 (12) e8432, e8432.1-e8432.11. doi: 10.1371/journal.pone.0008432

Nanoscale presentation of cell adhesive molecules via block copolymer self-assembly

George, P.A., Doran, M.R., Croll, T.I., Munro, T.P. and Cooper-White, J.J. (2009). Nanoscale presentation of cell adhesive molecules via block copolymer self-assembly. BIOMATERIALS, 30 (27), 4732-4737. doi: 10.1016/j.biomaterials.2009.05.039

To go boldly

Munro, Trent (2009). To go boldly. Australian Life Scientist, 6 (5)

A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP

Munro, T. P., Kwon, S., Schnapp, B. J. and St Johnston, D. (2006). A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP. Journal of Cell Biology, 172 (4), 577-588. doi: 10.1083/jcb.200510044

The Drosophila hnRNPA/B homolog, Hrp48, is specifically required for a distinct step in osk mRNA localization

Huynh, J. R., Munro, T. P., Smith-Litiere, K., Lepesant, J. A. and Johnston, D. S. (2004). The Drosophila hnRNPA/B homolog, Hrp48, is specifically required for a distinct step in osk mRNA localization. Developmental Cell, 6 (5), 625-635. doi: 10.1016/S1534-5807(04)00130-3

A molecular mechanism for mRNA trafficking in neuronal dendrites

Shan, Jianguo, Munro, Trent P., Barbarese, Elisa, Carson, John H. and Smith, Ross (2003). A molecular mechanism for mRNA trafficking in neuronal dendrites. Journal of Neuroscience, 23 (26), 8859-8866. doi: 10.1523/jneurosci.23-26-08859.2003

Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein

Ma, Alice S. W., Moran-Jones, Kim, Shan, Jianguo, Munro, Trent P., Snee, Mark J., Hoek, Keith S. and Smith, Ross (2002). Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. Journal of Biological Chemistry, 277 (20), 18010-18020. doi: 10.1074/jbc.M200050200

RNA trafficking and stabilization elements associate with multiple brain proteins

Snee, M., Kidd, G. J., Munro, T. P. and Smith, R. (2002). RNA trafficking and stabilization elements associate with multiple brain proteins. Journal of Cell Science, 115 (23), 4661-4669. doi: 10.1242/jcs.00137

UUCAC- and Vera-dependent localization of VegT RNA in Xenopus oocytes

Kwon, S., Abramson, T., Munro, T. P., John, C. M., Kohrmann, M. and Schnapp, B. J. (2002). UUCAC- and Vera-dependent localization of VegT RNA in Xenopus oocytes. Current Biology, 12 (7), 558-564. doi: 10.1016/S0960-9822(02)00740-6

RNA trafficking signals in human immunodeficiency virus type 1

Mouland, A. J., Xu, H. B., Cui, H. Y., Krueger, W., Munro, T. P., Prasol, M., Mercier, J., Rekosh, D., Smith, R., Barbarese, E., Cohen, E. A. and Carson, J. H. (2001). RNA trafficking signals in human immunodeficiency virus type 1. Molecular And Cellular Biology, 21 (6), 2133-2143. doi: 10.1128/MCB.21.6.2133-2143.2001

Repeated UUCACs are general cis-acting localization motifs in maternal RNAs that establish the germ layers in Xenopus

Kwon, S., Abramson, T., Munro, T. P., John, C. M., Koehrmann, M. and Schnapp, B. J. (2001). Repeated UUCACs are general cis-acting localization motifs in maternal RNAs that establish the germ layers in Xenopus. Molecular Biology of The Cell, 12, 362A-362A.

Binding of an RNA trafficking response element to heterogeneous nuclear ribonucleoproteins A1 and A2

Shan, Jianguo, Moran-Jones, Kim, Munro, Trent P., Kidd, Grahame J., Winzor, Donald J., Hoek, Keith S. and Smith, Ross (2000). Binding of an RNA trafficking response element to heterogeneous nuclear ribonucleoproteins A1 and A2. Journal of Biological Chemistry, 275 (49), 38286-38295. doi: 10.1074/jbc.M007642200

Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking

Munro, Trent P., Magee, Rebecca J., Kidd, Grahame J., Carson, John H., Barbarese, Elisa, Smith, Lisa M. and Smith, Ross (1999). Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking. Journal of Biological Chemistry, 274 (48), 34389-34395. doi: 10.1074/jbc.274.48.34389

Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymers

Gillard, M., Jia, Z., Jia, J., Song, M., Gray, P. P., Munro, T. P. and Monteriro, M. J. (2015). Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymers. European Society for Animal Cell Technology (ESACT), Barcelona, Spain, 31 May- 3 June 2015.

CD83 Expression On Human Immune Cells as a Target for Immunosuppression

Hart, D. N. J., Elgundi, Z., Ju Xinsheng, Verma, N. D., Silveira, P. A., Fromm, P. D., Alingcastre, R., Munster, D. J., Seldon, T. A., Sheng, Y., Jones, M. L., Munro, T. P., Mahler, S., Barnard, R. T., Vu, P. A., Lo, K., Shahin, K., Larsen, S., Bradstock, K. and Clark, G. J. (2015). CD83 Expression On Human Immune Cells as a Target for Immunosuppression. 33rd Annual Scientific Meeting of the Transplantation Society of Australia and new Zealand, Canberra, ACT Australia, 21-23 June 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/icb.2015.75

Characterisation of human CD83 expression on immune cells and their targeting with CD83 antibodies to prevent graft versus host disease in allogeneic haematopoietic cell transplantation

Hart, Derek N. J., Ju, Xinsheng, Elgundi, Zehra, Verma, Nirupama, Silveira, Pablo, Fromm, Phillip, Alingcastre, Renz, Hsu, Blake, Munster, David J., Seldon, Therese, Sheng, Yonghua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Al, Lo, Tsun Ho, Shahin, Kifah, Larsen, Stephen Robert, Bradstock, Kenneth and Clark, Georgina (2015). Characterisation of human CD83 expression on immune cells and their targeting with CD83 antibodies to prevent graft versus host disease in allogeneic haematopoietic cell transplantation. 57th Annual Meeting of the American Society of Hematology, Orlando, FL, United States, 5-8 Dec 2015. WASHINGTON: AMER SOC HEMATOLOGY.

Human Cd83 Expression On Immune Cells Validates Anti-Cd83 Prophylaxis to Prevent Graft Versus Host Disease in Allogeneic Haematopoietic Cell Transplantation.

Ju, Xinsheng, Elgundi, Zehra, Verma, Nirupama, Silveira, Pablo, Fromm, Phillip, Alingcastre, Renz, Munster, David, Seldon, Therese, Sheng, Yonghua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Ai, Lo, Tsun Ho, Shahin, Kifah, Clark, Georgina, Larsen, Stephen, Bradstock, Kenneth and Hart, Derek (2015). Human Cd83 Expression On Immune Cells Validates Anti-Cd83 Prophylaxis to Prevent Graft Versus Host Disease in Allogeneic Haematopoietic Cell Transplantation.. 14th Transplantation Science Symposium of the Transplantation-Society (TSS), Lorne, Australia, 11-13 November 2015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells

Orellana, Camila A., Marcellin, Esteban, Munro, Trent, Gary, Peter P. and Nielsen, Lars K. (2015). Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells. European Society for Animal Cell Technology (ESACT) Meeting, Barcelona, Spain, 31 May - 3 June 2015. London, United Kingdom: BioMed Central. doi: 10.1186/1753-6561-9-S9-O8

The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent

Verma, Nirupama D., Munster, David, Seldon, Therese, Sheng, Yong Hua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Phi Ai, Lo, Kevin, Shahin, Kifah, Elgundi, Zehra, Silveira, Pablo, Fromm, Phillip D., Clark, Georgina J., Larsen, Stephen, Bradstock, Kenneth and Hart, Derek N. J. (2015). The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent. BMT Tandem Meetings, San Diego, CA United States, 11-15 February 2015. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.bbmt.2014.11.527

The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent

Hart, D, Verma, N., Seldon, T, Sheng, Y., Pryor, R., Palkova, A., Findova, M., Jones, M., Munro, T., Mahler, S., Braet, K., Barnard, R., Marks, J., Coley, A., Fan, F., Zhou, Y., Vu, P, Lo, K., Shahin, K., Elgundi, Z., Silveira, P., Fromm, P., Clark, G., Larsen, S., Bradstock, K. and Munster, D. (2014). The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent. 2014 World Transplant Congress, San Francicso Ca, 26 - 31 July 2014. Malden, MA United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/ajt.12888

Exploring endosomal pathways using novel nanoparticle polymers as transfection reagents

Gillard, M., Truong N. P., Jia, Z., Monteiro M. J. and Munro, T. P. (2013). Exploring endosomal pathways using novel nanoparticle polymers as transfection reagents. 11th Protein Expression in Animal Cells Conference, Kananaskis, AB, Canada, 22-25 September 2013.

Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease

Hart, D, Seldon, T, Jones, M, Sheng, Y, Palkova, A, Cullup, H, Munro, T, Sinfield, L, Rice, AM, Wilson, J, Gray, P, Barnard, R, Mahler, S and Munster, D (2009). Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, 5-8 December 2009. Washington, D.C.: American Society of Hematology.

A molecular mechanism for messenger RNA trafficking in neuronal dendrites

Smith, R. W., Shan, J., Munro, T., Barbarese, E. and Carson, J. H. (2002). A molecular mechanism for messenger RNA trafficking in neuronal dendrites. ComBio 2002, Sydney, 29 September - 3 October, 2002.

hnRNP A3, A novel RNA cytoplasmic trafficking response element binding protein

Ma, A. S. W., Snee, M. J., Moran-Jones, K., Munro, T., Kidd, G. J. and Smith, R. W. (2001). hnRNP A3, A novel RNA cytoplasmic trafficking response element binding protein. ASBMB, Canberra, ACT, Australia, 31 September - 4 October, 2001.

Identification and subcellular localization of hnRNP A3: A protein that binds to the A2RE RNA trafficking sequence

Munro, T. P., Ma, A. S. W., Snee, M., Carson, J. H. and Smith, R. W. (2000). Identification and subcellular localization of hnRNP A3: A protein that binds to the A2RE RNA trafficking sequence. 2000 FASEB Summer Research Conference, Snowmass, Colorado, 2-11 June, 2000.

Trafficking of myelin basic protein RNA: Assciation of hnRNPs A1, A2 and A3 with the hnRNP A2 response element

Shan, J., Moran, K., Munro, T. P., Kidd, G., Winzor, D. J., Hoek, K. S. and Smith, R. W. (2000). Trafficking of myelin basic protein RNA: Assciation of hnRNPs A1, A2 and A3 with the hnRNP A2 response element. 2000 FASEB Summer Research Conf, Snowmass, Colorado, 2-11 June, 2000.

Biosensor evidence for the existence of sequence-specific and nonspecific RNA binding sites on HNRNP A2

Shan, J., Hoek, K. S., Kidd, G. J., Munro, T. P., Hall, D., Schindeler, A. J., Winzor, D. J. and Smith, R. W. (1999). Biosensor evidence for the existence of sequence-specific and nonspecific RNA binding sites on HNRNP A2. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Co-trafficking of HIV-1 VPR and Gag RNA in Oligodendrocytes

Mouland, A. J., Xu, H., Mercier, J., Cui, H., Munro, T., Prasol, M., Smith, R. W., Barbarese, E., Cohen, E. and Carson, J. H. (1999). Co-trafficking of HIV-1 VPR and Gag RNA in Oligodendrocytes. AIDS Conference, New York, June, 1999.

Mutational analysis of an hnRNP A2 response element for RNA trafficking

Munro, T., Magee, R. J., Kidd, G. J., Carson, J. H., Barbarese, E., Smith, L. M. and Smith, R. W. (1999). Mutational analysis of an hnRNP A2 response element for RNA trafficking. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry & Molecular Biology.

Anti-CD83 antibodies and use thereof

Seldon, T. A., Munster, D. J., Hart, D. N., Jones, M. L., Munro, T. P., Mahler, S. M., Zhou, Y. and Marks, D. (2013). Anti-CD83 antibodies and use thereof.

Release Media

Gray, Peter, Monteiro, Michael John and Munro, Trent Phillip (2013). Release Media. US9587104.

A2RE-mediated RNA transport

Munro, Trent Phillip (2001). A2RE-mediated RNA transport. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/uql.2020.832