The University of Queensland

Abstract A147: a HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging

Johnstone, Cameron N., Heery, Graham P., Kelly, Brian D, Humphries, James, Akhter, Dewan T., Thurecht, Kristofer J., Yuen, Daniel, Giannis, Michael, Yong, Ken, Chadwick, Gareth, Barker, Helena, Cargill, Anne, Eglezos, Anthony, Castellarnau, Alex, Paull, Jeremy R. A. and Hufton, Richard (2023). Abstract A147: a HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging. Molecular Cancer Therapeutics, 22 (12_Supplement), A147-A147. doi: 10.1158/1535-7163.targ-23-a147

Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation

Huda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2). doi: 10.1002/cmtd.202300036

Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s

Pizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2022). Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s. Biomacromolecules, 24 (1), 246-257. doi: 10.1021/acs.biomac.2c01105

Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials

Mills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J. and Fletcher, Nicholas L. (2022). Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials. Molecular Pharmaceutics, 19 (11), 4080-4097. doi: 10.1021/acs.molpharmaceut.2c00528

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416

Poly(2-ethyl-2-oxazoline) bottlebrushes: How nanomaterial dimensions can influence biological interactions

Pizzi, David, Mahmoud, Ayaat M., Klein, Tobias, Morrow, Joshua P., Humphries, James, Houston, Zachary H., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2021). Poly(2-ethyl-2-oxazoline) bottlebrushes: How nanomaterial dimensions can influence biological interactions. European Polymer Journal, 151 110447, 1-9. doi: 10.1016/j.eurpolymj.2021.110447

Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution

Humphries, James, Pizzi, David, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2020). Hyperbranched Poly(2-oxazoline)s and Poly(ethylene glycol): A structure–activity comparison of biodistribution. Biomacromolecules, 21 (8) acs.biomac.0c00765, 3318-3331. doi: 10.1021/acs.biomac.0c00765

Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures

Pizzi, David, Humphries, James, Morrow, Joshua P., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2019). Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures. European Polymer Journal, 121 109258, 109258. doi: 10.1016/j.eurpolymj.2019.109258

Understanding immunogenicity in nanomedicine

Humphries, James (2023). Understanding immunogenicity in nanomedicine. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/28b468b