The University of Queensland

Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a

Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346

Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific

Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2

µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7

McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600

On the utility of chemical strategies to improve peptide gut stability

Kremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga and Muttenthaler, Markus (2022). On the utility of chemical strategies to improve peptide gut stability. Journal of Medicinal Chemistry, 65 (8), 6191-6206. doi: 10.1021/acs.jmedchem.2c00094

Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers

Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina and Schroeder, Christina I. (2022). Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers. Journal of Biological Chemistry, 298 (3) 101728, 1-13. doi: 10.1016/j.jbc.2022.101728

Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides

Tran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452

The allosteric activation of α7 nAChR by α-Conotoxin MrIC is modified by mutations at the vestibular site

Gulsevin, Alican , Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina and Meiler, Jens (2021). The allosteric activation of α7 nAChR by α-Conotoxin MrIC is modified by mutations at the vestibular site. Toxin, 13 (8) 555, 555. doi: 10.3390/toxins13080555

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite

Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767

Improving the gastrointestinal stability of linaclotide

Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina and Muttenthaler, Markus (2021). Improving the gastrointestinal stability of linaclotide. Journal of Medicinal Chemistry, 64 (12) acs.jmedchem.1c00380, 8384-8390. doi: 10.1021/acs.jmedchem.1c00380

Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor

McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7

Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281

Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition

Tran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744

Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins

Tran, Hue (2022). Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/07b2aae